Description of effective substitutes for Movalis. Movalis tablets and injections: characteristics and review of analogues that are cheaper

pharmachologic effect

Movalis ® is a non-steroidal anti-inflammatory drug (NSAID), belongs to enolic acid derivatives and has anti-inflammatory, analgesic and antipyretic effects.

The pronounced anti-inflammatory effect of meloxicam has been established in all standard models of inflammation. The mechanism of action of meloxicam is its ability to inhibit the synthesis of prostaglandins, known inflammatory mediators.

Meloxicam in vivo inhibits the synthesis of prostaglandins at the site of inflammation to a greater extent than in the gastric mucosa or kidneys.

These differences are associated with more selective inhibition of cyclooxygenase-2 (COX-2) compared to cyclooxygenase-1 (COX-1). It is believed that inhibition of COX-2 provides therapeutic actions NSAIDs, while inhibition of the ubiquitous COX-1 isoenzyme may be responsible for side effects from the stomach and kidneys. The selectivity of meloxicam for COX-2 has been confirmed in various test systems, both in vitro and in vivo. The selective ability of meloxicam to inhibit COX-2 has been shown when used as a test system whole blood human in vitro. It was found that meloxicam (at doses of 7.5 mg and 15 mg) inhibited COX-2 more actively, having a greater inhibitory effect on the production of prostaglandin E 2 stimulated by lipopolysaccharide (a reaction controlled by COX-2) than on the production of thromboxane involved in the blood coagulation process. (reaction controlled by COX-1). These effects were dose dependent.

Ex vivo studies have shown that meloxicam (at doses of 7.5 mg and 15 mg) has no effect on platelet aggregation and bleeding time.

AT clinical research GI side effects were generally less common with meloxicam at doses of 7.5 and 15 mg than with other NSAIDs compared. This difference in frequency side effects on the part of the gastrointestinal tract is mainly due to the fact that when taking meloxicam, such phenomena as dyspepsia, vomiting, nausea, abdominal pain. The frequency of perforations in upper divisions The gastrointestinal tract, ulcers and bleeding associated with the use of meloxicam was low and depended on the dose of the drug.

Pharmacokinetics

Suction

Meloxicam is completely absorbed after i / m administration. The relative bioavailability compared to oral bioavailability is almost 100%. Therefore, when switching from injectable to oral forms, dose selection is not required. After the / m administration of the drug at a dose of 15 mg Cmax is 1.6-1.8 μg / ml and is reached in approximately 60-90 minutes.

Distribution

Meloxicam binds very well to plasma proteins, mainly to albumin (99%). Penetrates into synovial fluid, concentration in synovial fluid is approximately 50% of the plasma concentration. V d is low, averaging 11 liters. Interindividual differences are 7-20%.

Metabolism

Meloxicam is almost completely metabolized in the liver with the formation of 4 pharmacologically inactive derivatives. The main metabolite, 5"-carboxymeloxicam (60% of the dose), is formed by oxidation of the intermediate metabolite, 5"-hydroxymethylmeloxicam, which is also excreted, but to a lesser extent (9% of the dose). In vitro studies have shown that in this metabolic transformation important role CYP2C9 isoenzyme plays, CYP3A4 isoenzyme has additional significance. In the formation of two other metabolites (constituting, respectively, 16% and 4% of the dose of the drug), peroxidase takes part, the activity of which, probably, varies individually.

breeding

Excreted equally through the intestines and kidneys, mainly in the form of metabolites. Less than 5% of the daily dose is excreted unchanged in the feces; in the urine, unchanged, the drug is found only in trace amounts. The average T 1/2 meloxicam 13-25 hours Plasma clearance averages 7-12 ml / min after a single application.

Meloxicam demonstrates linear pharmacokinetics at doses of 7.5-15 mg when administered intramuscularly.

Pharmacokinetics in special clinical situations

Insufficiency of liver function, as well as mild or moderate renal failure, does not significantly affect the pharmacokinetics of meloxicam. The rate of elimination of meloxicam from the body is significantly higher in patients with moderately severe kidney failure. Meloxicam binds worse to plasma proteins in patients with end-stage renal disease. In end-stage renal disease, an increase in V d can lead to more high concentrations free meloxicam, so these patients daily dose should not exceed 7.5 mg.

Elderly patients compared with young patients have similar pharmacokinetic parameters. In elderly patients, the average plasma clearance during the equilibrium state of pharmacokinetics is slightly lower than in young patients. In older women, more high values AUC and long T 1/2 compared with young patients of both sexes.

Indications

— initial period treatment pain syndrome and short term symptomatic therapy rheumatoid arthritis, osteoarthritis (arthrosis, degenerative joint diseases), ankylosing spondylitis.

Dosing regimen

Osteoarthritis: 7.5 mg/day If necessary, this dose can be increased to 15 mg / day.

Rheumatoid arthritis:

Ankylosing spondylitis: 15 mg/day Depending on the therapeutic effect this dose may be reduced to 7.5 mg/day.

In patients with increased risk adverse reactions it is recommended to start treatment with a dose of 7.5 mg / day.

At patients with severe renal failure on hemodialysis, the dose should not exceed 7.5 mg/day.

Because potential risk adverse reactions depend on the dose and duration of treatment, the lowest possible dose and duration of use should be used. The maximum recommended daily dose is 15 mg.

Combined application

Do not use the drug simultaneously with other NSAIDs.

The total daily dose of the drug Movalis ® used in the form of different dosage forms should not exceed 15 mg. In / m administration of the drug is indicated only during the first few days of therapy. AT further treatment continue with oral dosage forms. The recommended dose is 7.5 mg or 15 mg 1 time / day, depending on the intensity of pain and severity. inflammatory process. The drug is administered by deep intramuscular injection. The drug should not be administered intravenously. Given the possible incompatibility, Movalis ® solution for intramuscular injection should not be mixed in the same syringe with other drugs.

Side effect

The following side effects are described, the relationship of which with the use of the drug Movalis ® was regarded as possible.

Within the system-organ classes, the following categories are used in terms of the incidence of side effects: very often (≥1 / 10); often (≥1/100,<1/10); нечасто (≥1/1000, <1/100); редко (≥1/10 000, <1/1000); очень редко (<1/10 000); не установлено.

From the hematopoietic system: infrequently - anemia; rarely - leukopenia, thrombocytopenia, changes in the number of blood cells, including changes in the leukocyte formula.

From the immune system: infrequently - other immediate-type hypersensitivity reactions; frequency not established - anaphylactic shock, anaphylactoid / anaphylactic reactions.

From the nervous system: often - headache; infrequently - dizziness, drowsiness.

From the side of the psyche: rarely - mood changes; frequency not established - confusion, disorientation.

From the sense organs: infrequently - vertigo; rarely - conjunctivitis, visual disturbances, including blurred vision, tinnitus.

From the side of the cardiovascular system: infrequently - increased blood pressure, a feeling of "rush" of blood to the face; rarely - palpitations.

From the respiratory system: rarely - bronchial asthma (in patients allergic to acetylsalicylic acid or other NSAIDs).

From the gastrointestinal tract: often - abdominal pain, dyspepsia, diarrhea, nausea, vomiting; infrequently - hidden or obvious gastrointestinal bleeding, gastritis, stomatitis, constipation, bloating, belching; rarely - gastroduodenal ulcers, colitis, esophagitis; very rarely - perforation of the gastrointestinal tract.

From the side of the liver and biliary tract: infrequently - transient changes in liver function tests (for example, increased activity of transaminases or bilirubin); very rarely - hepatitis.

From the skin and subcutaneous tissues: infrequently - angioedema, itching, skin rash; rarely - toxic epidermal necrolysis, Stevens-Johnson syndrome, urticaria; very rarely - bullous dermatitis, erythema multiforme; frequency not established - photosensitivity.

From the urinary system: infrequently - changes in indicators of kidney function (increased levels of creatinine and / or urea in the blood serum), urination disorders, including acute urinary retention; very rarely - acute renal failure.

General disorders and disorders at the injection site: often - pain and swelling at the injection site; infrequently - edema.

Co-administration with drugs that depress the bone marrow (eg, methotrexate) may cause cytopenia.

Gastrointestinal bleeding, ulceration, or perforation can be fatal.

As with other NSAIDs, the possibility of interstitial nephritis, glomerulonephritis, renal medullary necrosis, and nephrotic syndrome cannot be ruled out.

Contraindications for use

- hypersensitivity (including to other NSAIDs), complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history);

- erosive and ulcerative lesions of the stomach and duodenum in the acute phase or recently transferred;

- inflammatory bowel disease - Crohn's disease or ulcerative colitis in the acute phase;

- severe liver failure;

- severe heart failure;

- severe renal failure (if hemodialysis is not performed, CC is less than 30 ml / min, as well as with confirmed hyperkalemia);

- progressive kidney disease;

- active liver disease;

- active gastrointestinal bleeding, recent cerebrovascular bleeding or established diagnosis of diseases of the blood coagulation system;

- concomitant therapy with anticoagulants, tk. there is a risk of intramuscular hematoma formation;

- therapy of perioperative pain during coronary artery bypass surgery;

- pregnancy;

- lactation (breastfeeding);

- age up to 18 years;

- hypersensitivity to the active substance or auxiliary components of the drug. There is a possibility of cross-sensitivity to acetylsalicylic acid and other NSAIDs.

FROM caution:

- history of gastrointestinal diseases (presence of Helicobacter pylori infection);

- congestive heart failure;

- renal failure (CC 30-60 ml / min);

- cerebrovascular diseases;

- dyslipidemia / hyperlipidemia;

- diabetes;

- concomitant therapy with the following drugs: anticoagulants, oral corticosteroids, antiplatelet agents, selective serotonin reuptake inhibitors;

- diseases of peripheral arteries;

- elderly age;

- long-term use of NSAIDs;

- smoking;

- frequent use of alcohol.

Use during pregnancy and lactation

The use of Movalis ® is contraindicated during pregnancy.

It is known that NSAIDs penetrate into breast milk, so the use of the drug Movalis ® during breastfeeding is contraindicated.

As a drug that inhibits the synthesis of cyclooxygenase / prostaglandin, Movalis ® may affect fertility, and therefore is not recommended for women planning pregnancy. Meloxicam may delay ovulation. In this regard, in women who have problems conceiving and are being examined for such problems, it is recommended to stop taking the drug Movalis ® .

Use in children

Contraindicated in children and adolescents under 18 years of age.

Overdose

Data on cases associated with an overdose of the drug has not been accumulated enough. Likely to be present symptoms characteristic of an overdose of NSAIDs in severe cases: drowsiness, impaired consciousness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, acute renal failure, changes in blood pressure, respiratory arrest, asystole.

Treatment: antidote is not known. In case of an overdose of the drug, symptomatic therapy should be used. Cholestyramine is known to accelerate the elimination of meloxicam.

drug interaction

With the simultaneous use of other prostaglandin synthesis inhibitors with meloxicam, incl. GCS and salicylates (acetylsalicylic acid), increases the risk of gastrointestinal ulcers and gastrointestinal bleeding due to synergistic action. The combined use of meloxicam and other NSAIDs is not recommended.

Anticoagulants for oral administration, heparin for systemic use, thrombolytic agents, while used with meloxicam, increase the risk of bleeding. In the case of simultaneous use, careful monitoring of the blood coagulation system is necessary.

Antiplatelet drugs, serotonin reuptake inhibitors, when used simultaneously with meloxicam, increase the risk of bleeding due to inhibition of platelet function. In the case of simultaneous use, careful monitoring of the blood coagulation system is necessary.

NSAIDs increase plasma lithium levels by decreasing renal excretion. The simultaneous use of meloxicam with lithium preparations is not recommended. In case of need for simultaneous use, careful monitoring of the concentration of lithium in plasma is recommended during the entire course of the use of lithium preparations.

NSAIDs reduce the tubular secretion of methotrexate by the kidneys, thereby increasing its plasma concentration. The simultaneous use of meloxicam and methotrexate (at a dose of more than 15 mg per week) is not recommended. In the case of simultaneous use, careful monitoring of kidney function and blood count is necessary. Meloxicam may increase the haematological toxicity of methotrexate, especially in patients with impaired renal function.

There is evidence that NSAIDs can reduce the effectiveness of intrauterine contraceptive devices, but this has not been proven.

The use of NSAIDs while taking diuretics in case of dehydration of patients is accompanied by a risk of developing acute renal failure.

NSAIDs reduce the effect of antihypertensive drugs (beta-blockers, ACE inhibitors, vasodilators, diuretics), due to inhibition of prostaglandins, which have vasodilatory properties.

The combined use of NSAIDs and angiotensin II receptor antagonists enhances the effect of reducing glomerular filtration, thus, can lead to the development of acute renal failure, especially in patients with impaired renal function.

Colestyramine, binding meloxicam in the gastrointestinal tract, leads to its faster elimination.

NSAIDs, by acting on renal prostaglandins, may increase the nephrotoxicity of cyclosporine.

When using together with meloxicam drugs that have a known ability to inhibit CYP2C and / or CYP3A4 (or are metabolized with the participation of these enzymes), the possibility of pharmacokinetic interaction should be taken into account.

The possibility of interaction with oral antidiabetic drugs cannot be ruled out.

With the simultaneous use of antacids, cimetidine, digoxin and furosemide, no significant pharmacokinetic interactions were identified.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored in a place protected from light, out of the reach of children, at a temperature not exceeding 30°C. Shelf life - 5 years.

Application for violations of liver function

The drug is contraindicated in severe liver failure.

In patients with clinically stable liver cirrhosis, dose reduction is not required.

Application for violations of kidney function

The drug is contraindicated in severe renal failure (without hemodialysis).

At patients with end-stage renal disease on hemodialysis, the dose of Movalis should not exceed 7.5 mg.

At patients with mild or moderate impaired renal function (CC more than 25 ml / min) dose reduction is not required.

Use in elderly patients

Contraindicated in old age.

special instructions

Patients with gastrointestinal diseases should be monitored regularly. If an ulcerative lesion of the gastrointestinal tract or gastrointestinal bleeding occurs, Movalis ® must be discontinued.

Gastrointestinal ulcers, perforation, or bleeding may occur at any time during treatment, whether or not there are warning signs or a history of serious gastrointestinal complications. The consequences of these complications are generally more serious for the elderly.

When using NSAIDs, such serious skin reactions as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis can develop. Therefore, special attention should be paid to patients reporting the development of adverse events from the skin and mucous membranes, as well as hypersensitivity reactions to the drug, especially if such reactions were observed during previous courses of treatment. The development of such reactions is observed, as a rule, during the first month of treatment. In the event of the first signs of a skin rash, changes in the mucous membranes or other signs of hypersensitivity, the question of discontinuing the use of the drug Movalis ® should be considered.

Cases are described when taking NSAIDs increase the risk of developing serious cardiovascular thrombosis, myocardial infarction, angina attack, possibly fatal. This risk increases with prolonged use of the drug, as well as in patients with a history of the above diseases and predisposed to such diseases.

NSAIDs inhibit the synthesis of prostaglandins in the kidneys, which are involved in maintaining renal perfusion. The use of NSAIDs in patients with reduced renal blood flow or reduced circulating blood volume can lead to decompensation of latent renal failure. After discontinuation of NSAIDs, kidney function usually returns to baseline. Elderly patients, patients with dehydration, congestive heart failure, liver cirrhosis, nephrotic syndrome or acute renal dysfunction, patients concomitantly taking diuretics, ACE inhibitors, angiotensin II receptor antagonists, as well as patients who have undergone major surgical interventions that lead to hypovolemia. In such patients, diuresis and renal function should be carefully monitored at the beginning of therapy.

The use of NSAIDs in conjunction with diuretics can lead to sodium, potassium and water retention, as well as to a decrease in the natriuretic effect of diuretics. As a result, in predisposed patients, signs of heart failure or hypertension may be exacerbated. Therefore, careful monitoring of the condition of such patients is necessary, and they must be maintained adequate hydration.

Before starting treatment, a study of kidney function is necessary. In the case of combination therapy, renal function should also be monitored.

When using the drug Movalis ® (as well as most other NSAIDs), an episodic increase in the activity of transaminases in the blood serum or other indicators of liver function is possible. In most cases, this increase was small and transient. If the identified changes are significant or do not decrease over time, Movalis ® should be discontinued and monitoring of the identified laboratory changes should be carried out.

Debilitated or malnourished patients may be less able to tolerate adverse events, and therefore, such patients should be closely monitored.

Like other NSAIDs, Movalis ® may mask the symptoms of an underlying infectious disease.

As a drug that inhibits the synthesis of cyclooxygenase / prostaglandin, Movalis ® may affect fertility, and therefore is not recommended for women who have difficulty conceiving. In this regard, in women undergoing examination for this reason, it is recommended to stop taking the drug Movalis ®.

In patients with mild or moderate renal insufficiency (CC more than 25 ml / min), dose adjustment is not required.

In patients with cirrhosis of the liver (compensated), dose adjustment is not required.

Influence on the ability to drive vehicles and control mechanisms

Special clinical studies of the effect of the drug on the ability to drive a car and mechanisms have not been conducted. However, when driving and working with mechanisms, the possibility of developing dizziness, drowsiness, visual impairment or other disorders of the central nervous system should be taken into account. During the period of treatment, patients must be careful when driving and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Movalis is a remedy for inflammation and fever, which has several analogues. Using analogues instead of Movalis, the patient will be able to save a significant part of the funds and at the same time receive the same therapeutic result. The use of analogues is relevant for people with a limited budget or patients with intolerance to certain components of the original drug.

Movalis substitute is presented in several variations: gel, tablets, solution. The action of different forms does not differ from each other. You can choose the form that is most convenient for the patient. The active substance is the same as in the original.

Pros and cons of Movasin and Amelotex

Preparations similar in action to Movalis are produced under 2 names: Movasin and Amelotex. They have different forms:

. Applied externally, it is a transparent cooling gel.
. The basis of the product is the same composition as that of the above preparation. However, simple Amelotex is available in the form of tablets for internal use.
. Candles for rectal use.
. Produced in ampoules with a solution for intramuscular injection. Works faster than other forms.

An analogue of Movalis should be chosen based on budget considerations, as well as the form of the disease. In acute viral diseases, tablets are most effective. They instantly dissolve, so that the active substance quickly enters the bloodstream. It helps to cope with the temperature earlier than when using a gel or suppositories. At the same time, the gel is more effective for point inflammation and pain. It eliminates discomfort within 30 minutes, fights inflammation of the skin and tissues. Candles are suitable for both fighting fever and inflammation of the mucous membranes in the rectal area (for hemorrhoids, prostatitis).

Movasin is the most budget option. And Amelotex is an order of magnitude higher, but it has several forms of release at once. Gel, tablets or suppositories are much easier to use than ampoules. To enter the solution, you must have minimal medical skills. It should be borne in mind that intramuscular injections are very painful, with them a bruise may form on the surface of the skin. When buying ampoules, you will additionally have to spend money on injection syringes. Therefore, Movasin is more popular in medical institutions, and Amelotex is offered for home use.

pharmachologic effect

Both drugs are based on the effect on the enzymatic system. They slow down the cycle of enzymes, which leads to the following actions:

Decrease in body temperature.
Decreased sensitivity of the epidermis and nerve endings.
Elimination of inflammatory foci.
Regulation of blood circulation in the kidneys.
Improving the protection of the gastrointestinal mucosa.

The last 2 actions are minimally pronounced, so drugs are not prescribed for problems with the gastrointestinal tract and kidneys. Medications are non-steroidal, they are not addictive, they are considered anti-inflammatory.

Indications for use

The main effect of the original and analogues is the symptomatic elimination of pains of a pulsating or sharp nature. The drugs do not help with pain in the internal organs, mucosal disorders or wounds on the surface of the epidermis. They are aimed only at reducing the sensitivity of nerve endings, therefore they are used for diseases of the joints and bones:

osteochondrosis;
arthritis;
osteoarthritis, etc.

Can be used for Bechterew's disease.

The action does not depend on the form of release of the drug, therefore, the gel, tablets, and suppositories have the same recommendations for use.

Contraindications

Other contraindications to taking any drugs similar to Movalis:

minor age (up to 18 years);
violations of cardiac activity;
pregnancy and lactation;
bronchial asthma;
if the heart was operated on using aortic bypass surgery;
allergy;
stomach ulcer and other parts of the gastrointestinal tract;
liver disease, especially necrosis and liver failure;
internal hemorrhages;
inflammatory processes in the gastrointestinal tract.

People with weakened immune systems may also suffer from side effects or not tolerate drugs. The risk group primarily includes elderly patients, since they often suffer from several diseases at once from among contraindications: disorders of the heart, digestive system and liver. If the patient has a suspicion of 1 of the diseases incompatible with taking medications, it is imperative to consult a doctor.

Mode of application

The solution is administered exclusively intramuscularly for acute inflammation. The period of application should not exceed 3 days. People without major health problems but with severe pain may take up to 15mg. Patients prone to peptic ulcers and heart and liver problems should not receive injections with a dose of more than 7.5 mg per day.

The gel is used 2 times a day. Approximately 2 g is applied to the affected area. It is necessary to rub the composition into the skin with massaging movements. The course of treatment lasts no more than 1 month.

Tablets and suppositories are used in the same dosage as the solution. Tablets are taken 2 times a day before meals.

It is enough to apply 1 time per day.

Side effects

When taking pills, in rare cases, there are problems of the digestive tract. Up to 1 in 100 patients may experience intestinal discomfort, bloating, and colic. An even smaller proportion (1 out of 1000 people) experience side effects in the form of colitis, ulcers, internal bleeding. Often such phenomena are not caused by the action of medicines, but by their improper use.

Precautionary measures

In the case of taking several times the increased dose, gastric lavage is necessary. If the patient loses consciousness, has difficulty breathing, his throat begins to swell, it is urgent to call an ambulance. Only a qualified specialist is able to completely reduce the side effects of exceeding the daily dose.

Children and adolescents may be more sensitive to the components, resulting in an extensive allergic reaction.

If a woman is planning a pregnancy in the near future, the reception of analogues or the original should be abandoned. The active substance dramatically reduces fertility.

Elderly patients who constantly take the drug should be observed by a therapist about the normal functioning of the kidneys and liver. The same applies to people with heart problems and inflammatory processes in the gastrointestinal tract.

If at the time of admission a person does not suffer from an ulcer, cardiological problems, but there have been incidents before, then you need to regularly undergo preventive examinations with a specialist.

Interaction with other drugs

Preparations are poorly compatible with some drugs. The use of simultaneously considered medications and other NSAIDs can lead to serious disruption of the body:

Internal bleeding, mainly in the intestinal area.
The opening of ulcers in the gastrointestinal tract.

The same effect occurs when taking inhibitors directed against the production of serotonin. Such dangerous deviations as anemia or leukopenia may occur while taking Methotrexate. Under the influence of analogues, the effectiveness of contraceptives acting inside the body may decrease.

A more complete list of drugs that are not recommended for use at the same time as those under consideration can be found in the instructions for use. If precautions are not observed, the patient may develop renal failure, blood diseases, and intoxication.

Price category of drugs

The most winning replacement for Movalis is Movasin. The drug costs only 98 rubles. In comparison with the cost of the original medicine (653 rubles), this is 6 times less. At the same time, the number of tablets in the package and the concentration are the same.

Next on the list is . Due to the low weight of the package, the product costs only 276 rubles. At the same time, tablets from the same company will cost 437 rubles. Rectal suppositories can be purchased cheaper, at a price of 278 rubles, which is approximately equal to the cost of a gel. The increased price of tablets is due to the fact that they are more effective in extensive inflammation and heat.

The cheapness of analogues is not a sign of poor quality medicines. Customer reviews indicate that similar Russian-made drugs are in no way inferior to the original ones in terms of their pharmacological properties.

Other drugs based on meloxicam and phenolic acid can also be used against fever, pain or inflammation. Before using any product, you must carefully read the instructions. If you have any doubts about the safety of using the drug, be sure to consult with a specialist. Some phenolic acid-based medicines are used in a completely different area and cannot replace Movalis, so when buying, you need to carefully read the annotation.

Inflammatory processes in the joints must be treated with complex therapy, including the mandatory intake of medications. To eliminate diseases that cause degenerative-dystrophic processes in the articular tissue, it is recommended to take non-steroidal anti-inflammatory drugs, which include Movalis and its analogues.

About Movalis

A drug that eliminates joint pain and prevents inflammation. Movalis is recommended for use in pathological processes in the joints.

The drug is produced in the form of conventional tablets, suspensions and suppositories for rectal use. Solutions (for injection) are also produced, which are used for injection into muscle tissue.

The basis of the composition of all forms of release of the drug Movalis contains meloxicam (active ingredient).

Movalis in injections is effective in pathologies:

arthritis;
arthrosis;
spondylitis.

In addition to the main indications, Movalis is used to treat dorsopathy and arthropathy.

Contraindications:

composition intolerance;
bronchial asthma;
recurrent polyposis;
bleeding, perforation or ulcer of the gastrointestinal tract;
ulcerative colitis;
dysfunction of the kidneys, liver or heart;
lactation;
shunting of coronary arteries;
Pregnancy;
Age up to 12 years.

Movalis injections are contraindicated under the age of 18 years.

Side effect:

disruption of the stomach;
migraine, weakness;
increased blood pressure;
anaphylactic shock (rare);
allergy.

Price for Movalis:

ampoules (injections) - from 630 rubles;
tablets - from 700 rubles

Movalis is a prescription drug.

Analogues

The effectiveness of Movalis is confirmed by good reviews from patients, as well as specialists, however, the cost of the drug is quite high. In the absence of the possibility of acquiring an expensive medication, or there are contraindications to its use, you can choose an analogue of Movalis.

The reasons for replacing the funds with an analogue also include difficulties in acquiring the drug. Almost all drugs of the NSVP group are dispensed in a pharmacy by prescription. Diclofinac is freely available from Movalis analogues.

If you need to choose an analogue cheaper, then you should pay attention to the drugs:

Meloxicam;
Artrozan;
Movasin;
Amelotex;
Diclofinac.

The price of drugs is much lower, but this does not play a significant role in therapeutic effects.

Movalis analogues should be bought only after the doctor's consent to replace the prescribed remedy. In addition, we should not forget that most drugs are prescription.

Meloxicam

The anti-inflammatory drug Meloxicam is a direct analogue of Movalis. The medicine is prescribed for degenerative diseases of the articular tissue.

The analogue of Movalis contains the active substance of the same name - meloxicam, which has an analgesic and antipyretic effect.

The drug is produced in tablets and ampoules containing a solution for injection into the muscles.

Indications for injections and taking Meloxicam tablets:

rheumatoid form of arthritis;
arthrosis in the acute stage;
chronic type of polyarthritis;
ankylosing spondylitis.

The use of the Movalis analogue is not carried out if the patient has impaired functioning of the kidneys, heart or liver, in case of gastrointestinal diseases causing internal bleeding, or if there is an allergy to the constituent substances. The remedy is not prescribed for children under 15 years of age and women who are carrying or nursing a child.

An adverse reaction provokes visual impairment, tinnitus, migraines, blood disorders, indigestion / intestines. Injections can cause a burning sensation, as well as temporary pain at the injection site.

Similar pharmacological properties and the presence of the same active substance in the composition cause a completely natural question in patients about which is better Movalis or Meloxicam. Experts recognize that there is no significant difference between the drugs. The main difference is that Meloxicam, in addition to the solution for injection and tablets, is available in the form of a suppository.

The cost of an analogue is much cheaper: tablets - from 250 rubles; solution for injections - from 270 rubles.

Artrozan

The Russian analogue of the drug Movalis for the treatment of joints - Artrozan, is included in the group of selective drugs with anti-inflammatory effect.

Artrozan release form: tablets and solutions in ampoules for injection. The analogue contains meloxicam and additional components.

Indications for injections and taking pills:

arthritic inflammation of the joint;
ankylosing spondylitis;
development of osteoarthritis.

Since the composition of the analogue contains meloxicam, the contraindications to the drug correspond to the original remedy:

ulcerative lesions of the intestine and stomach;
intolerance to any of the components of the composition;
renal / hepatic / heart failure;
lactation period;
pregnancy;

Artrozan in injections is not prescribed to patients under the age of 18 years. Tablets are contraindicated for children under 15 years of age.

An adverse reaction to injections and tablets occurs in the form of a violation of functionality:

brain;
urinary system and kidneys;
circulatory system;
stomach / intestines;
organs of vision.

Artrozan tablets/injections can cause an allergic reaction, including anaphylactic shock.

The Russian-made drug belongs to cheap analogues with an average cost: tablets - from 170 rubles; injections - from 250 rubles.

Movasin

Non-steroidal anti-inflammatory drug of the group of selective inhibitors. Movasin acts on inflammatory processes in the tissues of the joints, preventing the development of diseases and providing an anti-symptomatic effect.

Movasin is produced in the form of a solution for injections, as well as tablets containing a medicinal substance - meloxicam.

The indication for oral administration and injections of Movasin is the need for symptomatic treatment against pathologies of the musculoskeletal system, characterized by inflammatory and degenerative processes: osteoarthritis, arthritis (rheumatoid) or Bechterew's disease. The drug has an analgesic effect.

Contraindications:

the age of children is less than 12 years (tablet form) and less than 15 years (injection form);
pregnancy or breastfeeding;
pathology of the kidneys / liver;
heart failure;
bronchial asthma;
bleeding and tendency to them;
damage to the gastrointestinal mucosa;
shunting of the aorta or coronary vessels;
allergy to the composition.

The main side effects on the composition of the drug:

flatulence, dispersion, vomiting, etc.;
weakness in the body;
headache;
jumps in blood pressure;
allergic reaction (including anaphylactic shock).

In rare cases, itching and mild pain appear at the injection site.

Movalis substitute - Movasin has an average price: injection solution - 600 rubles; tablets - 500 rubles.

Amelotex

The anti-inflammatory drug Amelotex is an inexpensive analogue of Movalis, containing a similar active ingredient - meloxicam. In addition to the main action, the drug acts on the body as an antipyretic and analgesic.

Unlike the original and other analogues, Amelotex is produced not only in the form of a solution for injections, tablets and suppositories, but also in the form of a gel used for external application.

Amelotex is recommended for the development of ankylosing spondyloarthritis, rheumatoid arthritis and osteoarthritis. Injections are prescribed to block degenerative changes and eliminate pain. The gel is also used to eliminate pain in the joints.

Contraindications for oral, rectal, external administration and injections of Amelotex:

the period of bypassing the heart vessels;
inflammatory processes in the gastrointestinal tract;
kidney or liver dysfunction;
bleeding of any nature;
an allergic reaction to the components;
heart pathology;
lactation / pregnancy;
bronchial asthma.

The Movalis analogue in the form of a gel, in addition to the main contraindications, is not recommended for violation of the integrity of the skin.

Side reaction:

allergy;
violation of the functionality of the nervous system;
upset stomach and intestines;
bronchospasm;
temporary dysfunction of the urinary organs;
violation of visual functions;
increase in pressure.

During the injection, pain and burning may occur at the injection site.

Gel Amelotex in rare cases causes rashes, peeling and hypothermia, manifested on the skin.

The cost of the Russian analogue - Amelotex: tablets - from 110 rubles; injections - from 150 rubles.

Diclofinac

The drug Diclofinac differs from other analogues, as well as from Movalis, by a wider spectrum of action, a large assortment of release forms and composition (the active ingredient is sodium diclofinac). However, the analog also applies to non-steroidal drugs used against diseases of the articular tissue.

Manufacturers of the drug produce the drug in the form of: tablets, gel, injection, ointment, rectal suppositories.

Indications for symptomatic drug therapy, including the use of gel and injections, include diseases:

pain syndromes of muscles and joints;
inflammation and pathological changes in the joints (arthrosis, bursitis, etc.);
inflammatory diseases of the small pelvis;
algomenorrhea;
fever symptoms.

Injections can be used for course treatment of the musculoskeletal system with the development of inflammation and degenerative-dystrophic processes of the joints or muscles.

An analogue in the form of an ointment and gel is also prescribed in order to eliminate pain after injuries, including in the postoperative period.

Before replacing Movalis with Diclofinac, you should familiarize yourself with the contraindications to the analogue:

damage to the mucous membrane of the gastrointestinal tract;
pathological processes in the kidneys / liver;
problems with cardiac activity;
shunting of the vessels of the heart;
lactation and third trimester of pregnancy;
intolerance to at least one of the components of the composition.

For children, an analogue of Movalis is prescribed:

tablets - from 6 years;
candles - from 14 years old;
gel / ointment - from the age of 14;
injections - from 18 years.

Adverse reaction to the drug Diclofinac:

migraines and dizziness;
diarrhea or constipation;
spasms, pain, ulcers, flatulence or bleeding in the gastrointestinal tract;
urinary retention;
allergies in the form of a rash or itching;
noise in ears.

Injections and suppositories can provoke local symptoms: burning, necrosis and tissue infiltration.

Diclofinac is the most inexpensive analogue of Movalis. The minimum price for the drug: tablets - 30 rubles; injections - 60 rubles; ointment / gel - 50 rubles.

Conclusion

The drug Movalis or its analogues should be prescribed by a specialist. Non-steroidal anti-inflammatory drugs have many contraindications, and can also cause side effects, so drugs of this type are dispensed in pharmacies by prescription.

Movalis (meloxicam) is one of the effective non-steroidal anti-inflammatory drugs. The drug belongs to the group of oxycams and is a derivative of enolic acid. This is an original drug developed by the German company Boehringer Ingelheim. The main advantage of Movalis is selectivity. It selectively affects cyclooxygenase-2, while the first generation NSAIDs affect COX-1 and COX-2, which increases the frequency and number of side effects.

Cyclooxygenase is an enzyme necessary for the synthesis of prostaglandins, mediators of inflammation. The drug blocks this enzyme, which causes an anti-inflammatory effect. It also has analgesic, antipyretic effects, and is mainly prescribed in the complex therapy of rheumatoid arthritis (RA), ankylosing spondylitis and osteoarthritis.

Movalis is available in injectable form and in tablets. 1 ampoule contains 1.5 ml of a solution with 15 mg of meloxicam. Packed in a cardboard box of 5 and 3 ampoules. The drug is administered intramuscularly, not more than 15 mg 1 time per day. Due to the relatively invasive method of administration, it is prescribed only in cases where oral NSAIDs do not have the desired effect.

Movalis is produced with different dosages: 7.5 (20 pcs per pack) and 15 mg (10 and 20 pcs per pack). Due to the fact that the drug is branded, treatment with it can be expensive, so various manufacturing companies produce analogues of Movalis, which are several times cheaper.

Prices for the drug and its main analogues, average in Russia

In a double-blind, randomized study in which 9000 patients with osteoarthritis took part, the efficacy and incidence of side effects of meloxicam and non-selective NSAIDs were compared. It turned out that the anti-inflammatory effect of meloxicam is not inferior to non-selective NSAIDs, and the frequency of side effects in the meloxicam group was 1.5 times lower. These indicators give grounds for the widespread use of this drug. Since there are many analogues of Movalis, which are cheaper, therefore, for any patient, you can choose the necessary therapy without significant costs.

The main similar means of Movalis are presented in several pharmacological forms.

Analogues in two forms: solution and tablets

Many analogues of Movalis also have two forms of release, which allows the patient to choose the most appropriate dosage and speed of action of the agent.

Amelotex

The drug Amelotex (meloxicam) is an analogue of Movalis in injections and tablets. Presented in different dosages:

tablets of 7.5-15 mg;
ampoules 15 mg / 1.5 ml;
suppositories of 7.5-15 mg;
gel for external use 1% - 30 g and 50 g.

Amelotex is manufactured by Sotex, Skopje, Republic of Macedonia.

The drug has an analgesic, anti-edematous, anti-inflammatory effect due to the inhibition of the synthesis of pro-inflammatory agents. It is prescribed in combination with other medicines to reduce the manifestations of the inflammatory process, reduce pain in RA, osteoarthritis, Bechterew's pathology. The drug does not affect the progression of the underlying disease.

Take pills during meals, the daily rate should not exceed 15 mg per day. In pathologies of the kidneys with a pronounced violation of their function, the dosage is reduced to 7.5 mg / day. Injection Amelotex is injected into the gluteal muscle no more than 15 mg per day. Injections are prescribed in cases where the tablets do not have the desired effect, or oral administration is not possible for any reason.

The drug is contraindicated in patients with ulcerative-erosive lesions of the gastrointestinal tract, with bronchial asthma in the complex intolerance to Aspirin, heart and kidney failure, hepatargy, during pregnancy and lactation, in childhood, with allergic reactions to the drug, hemocoagulation disorders.

The highest concentration in the blood of Amelotex is achieved after 2-3 hours, while Movalis - after 5-6 hours when taken orally. Also, the medication differs from Movalis in cost (the price of 3 ampoules of Amelotex does not exceed 315 rubles).

Artrozan

Artrozan (the active substance is meloxicam) is produced by the Russian company Pharmstandard-Leksredstva. Belongs to the group of selective NSAIDs, used as an antirheumatic agent. Due to the blocking effect on the enzyme necessary for the synthesis of PG, there is an anti-inflammatory, analgesic, antipyretic effect. It is prescribed for the symptomatic treatment of RA, ankylosing spondylitis, osteochondrosis, osteoarthritis.

Orally, Artrozan is used once a day, with food, at a dosage of 7.5-15 mg. The drug in ampoules (6 mg / ml, 2.5 ml) is intended for injection into the muscle. The maximum dosage is not more than 15 mg per day.

Contraindications for use are the following conditions:

Childhood and puberty.
Recurrence of gastric and duodenal ulcers.
Gastric bleeding, gastric perforation.
Colitis, enterocolitis.
Hypersensitivity reactions to the drug.
Conditions after coronary artery bypass grafting.

In terms of bioavailability, Artrozan is inferior to Movalis (F Artrozan - 89%, Movalis - 89-99%). The highest content in the blood of Artrozan is achieved after 5 hours, Movalis - after 5-6 hours when taken orally. The price of Artrozan, unlike Movalis, is more democratic and averages 300 rubles. for 3 ampoules.

Bi-xicam

The manufacturer of the medicinal product is Veropharm, Russia. Bi-xicam is an NSAID with a predominant effect on cyclooxygenase-2, due to which analgesic and anti-inflammatory effects are manifested.

Indications for use are similar to Movalis (RA, osteochondrosis, ankylosing spondylitis and other diseases of the musculoskeletal system, accompanied by inflammation, degeneration with severe pain).

Tablets are taken orally with water. The maximum amount of the drug is not more than 15 mg. The dosage of Bi-xicam in solution for injection is 15 mg / 1.5 ml. The drug is administered intramuscularly once a day. Therapy is prescribed in small courses (up to 4-6 days).

The drug is contraindicated if the history includes:

peptic ulcer in the acute stage, NSAID-associated gastric ulcer, bleeding or perforation,
hepatargy,
renal failure without organ replacement therapy,
violation of blood coagulation, cerebral, gastrointestinal bleeding;
severe heart failure (HF).

Also, taking drugs is contraindicated in such cases:

Concurrent use of blood thinners.
Pregnancy, lactation period.
Hypersensitivity to the drug.
In the treatment of cardialgia before surgery.
Age up to 18 years.

In terms of bioavailability, Bi-xicam is inferior to Movalis (F Bi-xicam - 89%, Movalis - 89-99%). Bi-xicam is a more budget option. The cost of tableted Bi-xicam 15 mg No. 20 averages 300 rubles.

Liberum

Liberum is a meloxicam-containing drug, produced in Ukraine. Produced by the company "Farmak" (Kyiv). Refers to the derivatives of enolic acid, non-steroidal anti-inflammatory agent. By inhibiting the synthesis of PG, it has an anti-inflammatory effect.

Liberum in tablets containing 7.5-15 mg of meloxicam is prescribed once a day. The starting dosage can start at 7.5 and increase to 15 mg / day, but no more. Liberum solution for intramuscular injection is prescribed once a day up to 15 mg / day. It should be injected deep into the gluteal muscle.

Indications for use in Liberum are the same as in Movalis and include therapy for RA, arthrosis, ankylosing spondylitis (AS) and other diseases of the osteoarticular system, accompanied by inflammatory changes and severe pain.

Liberum is contraindicated in pregnant women, nursing mothers, in childhood and puberty, with drug intolerance, pathologies of the hemocoagulation system, patients with aspirin-associated BA, HF, acute renal failure, chronic renal failure, hepatargia, erosive and ulcerative pathology of the stomach and intestines.

Melbeck

Country of origin - Turkey. The drug belongs to the group of NSAIDs, contains meloxicam - from the group of oxycams. Reduces inflammatory activity and pain by inhibiting pro-inflammatory substances. Indications include symptomatic therapy of RA, AS, arthritis, in particular osteoarthritis.

Malbek is prescribed 1 tablet (containing 7.5-15 mg of meloxicam) per day at the same time as meals. Parenteral Melbek is injected into the muscle at a dosage of 15 mg / day.

Reception of Melbek is contraindicated in the 3rd trimester of pregnancy, under the age of 18 years, with hypersensitivity to the drug, NSAID-associated peptic ulcer, history of gastrointestinal tract, perforation, peptic ulcer, hepatargia, renal failure without the use of dialysis, hemocoagulation disorders, cerebral bleeding , concomitant use of anticoagulants, severe HF, in the treatment of cardialgia before CABG surgery.

The bioavailability of Melbek is 89-95%, the original Meloxicam is 89-99%. The price of Melbek is small: it averages 350 rubles. for 3 ampoules.

Movasin

The Russian-made medicine, which is produced by Sintez OJSC, is presented in the form of tablets of 7.5 and 15 mg and ampoules of 15 mg / 1.5 ml. Drug group: NSAIDs, antirheumatic agent, oxicam derivative - meloxicam. The drug has an analgesic, anti-inflammatory, anti-edematous and slight antipyretic effect by suppressing the synthesis of prostaglandins. Unlike Movalis, Movasin is several times cheaper.

Mode of application. Possible therapy with a starting dose of 7.5 mg / day with an increase in dose of not more than 15 mg / day. Take the medication 1 time per day at the time of eating. It is used in the complex therapy of RA, AS, osteochondrosis, osteoarthrosis, and other inflammatory and degenerative diseases of the joints with severe pain.

The drug is contraindicated in the presence of the following anamnestic data:

gastric ulcer associated with long-term use of NSAIDs;
gastrointestinal bleeding perforation;
recurrent peptic ulcer;
hepatargia;
renal failure without dialysis;
violation of blood coagulation, cerebral, gastrointestinal bleeding;
concomitant use of blood thinners;
with severe heart failure;
for the purpose of pain relief before coronary bypass surgery;
pregnancy, lactation period;
hypersensitivity to the drug;
age less than 18 years.

Meloxicam

The drug is available in the following dosage forms:

Tablets of 7.5-15 mg.
Solution for i / m administration of 15 mg / 1.5 ml.
Rectal suppositories 7.5-15 mg.

Pharmacogroup: NSAIDs, a derivative of oxicams - meloxicam. It has an anti-inflammatory and analgesic effect, affects the pathogenesis of inflammation.

The application depends on the form of the product:

Tablets are taken at 7.5-15 mg 1 time per day with a sufficient amount of liquid.
The solution is used at 7.5-15 mg / day. intramuscularly.
Suppositories are introduced into the rectum at a dose of 7.5-15 mg 1 time per day.

The maximum allowable daily dosage is 15 mg / day. Indications for use are anti-inflammatory and analgesic therapy for patients suffering from RA, osteochondrosis, ankylosing spondylitis.

Contraindications include hypersensitivity, pregnancy and lactation, acute renal failure, chronic renal failure, hepatargia, heart failure, gastric ulcer, Crohn's disease, UC, proctitis, hemorrhoids, history of rectal hemorrhages.

Meloxicam, unlike Movalis, is also presented in suppositories for rectal use, which is a definite plus, especially in cases where oral and parenteral administration of the substance is not possible. The highest content in the blood of Meloxicam is achieved after 2.5 hours, while Movalis - after 5-6 hours when taken orally. The low cost of Meloxicam (the price of 20 tablets of 15 mg is 45-75 rubles) makes it a more affordable remedy.

Similar drugs in tablet form

The main analogues of Movalis in tablet form are represented by the following drugs: Lem, Mixol-Od, Mirloks, M-Kam, Oxycamox, Exen-Sanovel, etc.

Lem

LS Lem is produced by the Russian company Obolenskoye (Obolensk). Lem refers to NSAIDs, the main component is meloxicam. The action of the drug is aimed at pain relief and suppression of the pathological inflammatory reaction in rheumatological diseases.

Lem tablets are taken orally at the same time as meals, 1 time per day, 7.5-15 mg, the maximum dose is 15 mg / day.

The medicine is prescribed in such cases:

Rheumatoid arthritis.
Bechterew's disease.
Osteoarthritis, osteoarthritis.
Arthralgia.

You can not use the drug for:

pregnancy and lactation;
peptic ulcer due to long-term use of NSAIDs;
blood clotting disorders;
cerebral, gastrointestinal bleeding;
children under 18;
with hypersensitivity to the drug;
history of gastrointestinal bleeding or perforation;
recurrence of peptic ulcer;
hepatargy;
AKI, CRF without dialysis;
severe heart failure;
concomitant use of anticoagulants;
pain management before coronary bypass surgery.

Mixol-Od

Drug group: NSAIDs, selective inhibitor of cyclooxygenase-2. The drug has anti-inflammatory, analgesic, slight antipyretic effect. Mixol-Od is currently not available in pharmacies.

Method of application: Mixol-Od at a dosage of 7.5-15 mg is taken orally simultaneously with meals, once a day, in short courses (up to 4-5 days). The amount of the drug taken should not exceed 15 mg / day.

Indications are diseases of the joints, accompanied by inflammatory and degenerative manifestations in combination with pain (arthrosis, RA, Bechterew's disease, osteoarthrosis).

Contraindications are the following conditions:

Pregnancy, lactation.
Age less than 15 years.
Hypersensitivity reactions to the components of the drug.
Peptic ulcer of the stomach and 12 PC (relapse).
Severe dysfunctional conditions of the liver and kidneys.
GCC, perforation of the stomach.
Conditions after CABG.
Recurrent colitis, enterocolitis.

Mirloks

Mirloks is a Polish-made drug containing meloxicam. Drug group: non-steroidal anti-inflammatory drugs, selective, antirheumatic. By suppressing the COX-2 enzyme, the synthesis of inflammatory mediators - prostaglandins, decreases, pain, swelling and redness in the inflammatory focus decreases.

Method of application: Mirloks tablets are taken in short courses once a day (7.5-15 mg each). It should not be allowed to exceed the daily dosage of more than 15 mg / day.

Mirlox is used in the symptomatic treatment of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis. The use of drugs is contraindicated in such cases: aspirin-associated BA, hypersensitivity to the components of the drug, non-dialysis renal failure, severe liver failure, pregnancy and lactation, age up to 15 years, ulcerative lesions of the gastrointestinal tract, should be used with caution in the elderly.

The cost of Mirloks on average is 242-296 rubles. per package containing 20 tablets of 15 mg meloxicam. This is several times cheaper than the branded drug - Movalis.

M-Kam

M-Kam is an Indian meloxicam. Refers to selective NSAIDs, antirheumatic agent. It exerts its effect by inhibiting the COX-2 enzyme, resulting in a decrease in the synthesis of pro-inflammatory substances. It is prescribed for RA, OA, AS and other inflammatory diseases of the bones and joints, accompanied by pain.

In tablet form, M-Cam is used once a day, simultaneously with meals. The daily dosage is 7.5-15 mg.

M-Kam is contraindicated in patients with aspirin-associated BA, HF, acute renal failure, chronic renal failure, gastric ulcer and 12 PC, with erosive and ulcerative lesions of the intestine, hypersensitivity to the drug, hemocoagulation disorders, hepatargia. You can not use the medicine during pregnancy and during breastfeeding, in childhood and adolescence.

The highest concentration in the blood of M-Kam is achieved after 4-5 hours, Movalis - after 5-6 hours when taken orally. The metabolization period of Movalis is 20 hours, M-Kama is 15-20 hours. It differs from Movalis in cost (the price of 3 ampoules of Amelotex does not exceed 315 rubles)

Oxycamox

Oxycamox is an Indian drug containing meloxicam. Influencing the biosynthesis of prostaglandins in the focus of inflammation, it exhibits a pronounced anti-inflammatory effect, reduces pain.

Oxycamox is prescribed once a day, at a dosage that does not exceed 15 mg. The drug is taken orally with a liquid. Therapy can be started with 7.5 mg with an increase in the future to a maximum of 15 mg / day.

It is prescribed in the complex therapy of RA, osteochondrosis, AS, osteoarthritis, gout and other inflammatory diseases of the joints with severe arthralgia.

Oxycamox is contraindicated in the following cases:

Relapse of gastric and duodenal ulcer.
Childhood and adolescence.
Conditions after CABG, HF.
Severe liver and kidney dysfunction.
drug intolerance reactions.
GCC, perforation of the stomach.
Colitis, enterocolitis in the acute stage.
Pregnancy, lactation period.

Exen-Sanovel

Exen-Sanovel - Turkish-made tablets, meloxicam-containing selective NSAIDs. By inhibiting the enzymatic activity of cyclooxygenase-2, the drug suppresses inflammatory activity in the focus of inflammation, as well as anesthetizes and reduces local and general body temperature.

Exen-Sanovel is used one tablet per day at a dosage of 7.5-15 mg of meloxicam. The drug is prescribed for RA, OA, Bechterew's disease as a symptomatic therapy. The drug does not affect the progression of the underlying disease.

Contraindicated in hepatargy, pathologies of the hemocoagulation system, heart failure, acute renal failure, erosive and ulcerative lesions of the intestine, patients with aspirin-associated BA, chronic renal failure, gastric ulcer and duodenal ulcer, pregnant women, nursing mothers, in childhood and adolescence, with drug intolerance.

The average price of "Movalis" varies from 500 to 800 rubles, depending on the region. Russian "Movalis" - "Amelotex" and "Artrozan", their price is approximately 150 rubles, four times.

Another substitute for Movalis is Bi-Xikam, the price per pack is from 80 to 100 rubles, the cost is five times less.

The use of "Movalis"

It attracts the drug with good absorbability: when taking tablets, the bioavailability of the drug is about 80-90%.

The main active ingredient is meloxicam. The tool has a high selectivity of action and acts at the destination, slightly damaging the gastrointestinal mucosa. Metabolic products are completely excreted mainly through the urinary system, with feces no more than 5-6%. The withdrawal period of the drug is about 20-24 hours.

Assign "Movalis" or its substitutes as a symptomatic remedy for the following diseases:

Rheumatoid arthritis;

Spondylosis;

Degenerative changes in the tissue of the joints.

The daily dose should not exceed 7.5 mg; in adolescents, the dose is calculated at 0.25 mg per 1 kg of body weight.

Do cheap analogues of Movalis have side effects

Meloxicam (the active substance of Movalis and its cheap analogues) when taken can cause the following side effects:

On the part of the hematopoietic system, anemia, a decrease in the number of leukocytes and platelets in the blood can be observed;

From the side of the central nervous system: headaches, dizziness, confusion, mood swings, drowsiness;

From the gastrointestinal tract: the occurrence of gastritis, colitis, peptic ulcer, nausea, vomiting, constipation or diarrhea, bloating, pain in the stomach, stomach, intestinal bleeding, drug-induced hepatitis;

From the respiratory system: the risk of bronchial asthma;

From the excretory system: impaired renal function, acute renal failure, acute urinary retention;

Perhaps the development of an allergic reaction: angioedema, immediate anaphylactic shock, allergic necrolysis of the epidermis, urticaria, itching, bullous dermatitis.

Do cheap analogues of Movalis have contraindications

Absolute contraindications to taking meloxicam are:

Severe renal and hepatic insufficiency;

Peptic ulcer, colitis in the acute stage;

Heart failure, previous coronary artery bypass grafting;

CNS diseases;

Bronchial asthma.

Not recommended for pregnant women, nursing mothers, children under 12 years of age. The elderly should be administered with caution. It is also necessary to minimize the dosage if there was a history of gastrointestinal diseases: in this case, the risk of developing internal bleeding, which can be fatal, is increased. Caution should be taken by people with diabetes mellitus, who have had hepatitis, and who are prone to developing allergies. At the time of admission, you must stop smoking and drinking alcohol.

The drug is prescribed only as prescribed by the attending physician. If side symptoms occur, you should contact a specialist to adjust the dosage or stop the drug. According to customer reviews from cheap analogues of Movalis, Bi-Xikam has minimal side effects, Artrozan is in second place.