Table janine. How to take Janine correctly: a hormonal contraceptive drug. Release form and composition

The world's first contraceptive pill appeared in the United States in 1960. By modern standards, it contained a monstrous amount of hormones: 10 mg of norethinodrel acetate and 150 mcg of mestranol. The drug was called Enovid and was not particularly popular, mainly due to severe side effects.

Of course, modern contraceptives have come a long way from their ancestors. A correctly selected drug does not have negative effects on a woman’s body, has a minimum of side effects and allows you to plan a pregnancy. One such means is the birth control pill Janine.

Mechanism of action

According to the classification, Zhanine belongs to monophasic low-dose contraceptives. That is, it contains the same amount of hormones in all tablets, of which there are 21 in a package. In other words, you will receive the same dose of hormones throughout your entire menstrual cycle.

Janine is a combination drug containing two hormones. Each tablet contains the hormone dienogest, obtained synthetically. It is a complete analogue of progesterone produced by the female body. The second hormone is ethinyl estradiol, which is identical to female estrogens.

The contraceptive effect of Janine develops in several directions:

• The hormones included in the composition create a certain background in the body in which the next egg does not mature and does not leave the follicle, that is, they suppress ovulation.
• Hormones block the release of substances that are responsible for stimulating the ovulation process itself.
• They cause changes in the endometrium and thereby prevent the implantation of the egg, if, by an incredible coincidence, ovulation and fertilization did occur.
• They increase the viscosity of the secretion in the cervix, and it becomes almost completely impermeable to sperm.

Thanks to this multi-level mechanism of protection against pregnancy, Janine is one of the most effective means of family planning.

If you use Zhanine correctly and do not miss taking pills, then the Pearl index, which determines the reliability of all contraceptives, will be less than one.

This means that in one hundred women who protected themselves for a year without interruption with this drug, only one became pregnant.

Features of application

Some women are frightened by the fact that Janine prevents the onset of ovulation. It may seem that he is forever able to suppress it. However, this is not at all true. Janine does not affect the number of eggs that can mature during a normal cycle. It simply “turns off” the ovaries for a while and gives them the opportunity to rest. But when you stop taking them, they begin to work in full force again.

Indications

The main indication for use of Janine is contraception. However, there are a number of conditions for which hormonal and contraceptive drugs can also be prescribed. At the same time, the opportunity to plan a pregnancy will be a bonus to the action that you need to get in the end. These conditions include:

• Seborrhea, acne or hirsutism, in which women's hair grows in a male pattern.
• Baldness, which also occurs in the male pattern, when hair loss begins mainly in the frontal and parietal region, caused by a lack of female hormones.
• Endometriosis, in which Janine helps mainly by suppressing the growth of the endometrium of the uterus and reducing such manifestations of the disease as heavy bleeding, disrupted cycles and pain.
• Some types of ovarian cysts.
• Delaying or changing the next date of the onset of menstrual bleeding.

Contraindications

Despite the fact that modern hormonal drugs are a fairly safe group of drugs, contraindications to their use still exist. In some conditions, the use of Janine is absolutely contraindicated; in others, it can be used, but only under the strict supervision of a doctor.

Absolute contraindications:

• Suspicion of pregnancy.
• Uterine bleeding of unknown origin.
• Lactation period.
• Allergy to the components that make up Janine, including auxiliary ones.

If you have at least one of these conditions, then you should absolutely not take the drug. In addition, Janine should not be drunk:

• For thrombosis, thromboembolism, regardless of the reasons that caused them and whether you have them now or have had them in the past.
• For any other pathologies associated with disorders that occur in the vascular system, especially after strokes or heart attacks.
• For migraines with aura, which are characterized by the presence of various neurological symptoms. Often these are visual and hearing impairments, clouding of consciousness, fainting and panic attacks.
• For severe liver diseases.
• For diabetes mellitus, especially with vascular complications.
• For any hormone-dependent diseases that are difficult to treat.

Relative contraindications

There are conditions in which taking Janine is not prohibited, but it should only be used if the benefit obtained will outweigh the risk of exacerbations or complications. These include:

• Conditions associated with a high risk of blood clots, such as being overweight, smoking, or migraines without aura.
• Hereditary predisposition to the formation of blood clots. It is possible for you if one of your close relatives suffered from venous diseases, suffered a stroke or heart attack.
• Angioedema is also hereditary.
• Pathologies that can provoke circulatory disorders. For example: Crohn's disease, ulcerative colitis, systemic lupus erythematosus, inflammation of the superficial veins or some types of anemia.
• Hypertriglycerdemia is a disease, often also of a hereditary nature, in which high levels of lipids are found in a person’s blood.

If any of these conditions first appeared to you while taking Janine, then you should stop taking the drug and be sure to consult a doctor as soon as possible.

Side effects

In most cases, Janine is tolerated quite well. However, side effects also occur when taking it. They will be most pronounced at the very beginning of use; as a rule, they go away on their own over time and do not require discontinuation of the drug. According to the instructions, most often the following may occur:

• Headache, appearance or exacerbation of existing migraines, dizziness, surges in blood pressure.
• Nausea, upset, pain in the lower or upper abdomen.
• Pain, engorgement of the mammary glands.
• Changes in mood, fatigue, and sometimes insomnia.

More serious side effects occur much less frequently, according to clinical studies, no more than one case per thousand doses of the drug. These include:

• Exacerbation of genitourinary system infections, the appearance of thrush or vulvovaginitis.
• Allergic reactions are usually allergic dermatitis.
• Pain in the back or limbs, myalgia.
• Various disorders associated with the vascular system, such as varicose veins, thromboembolism, and the formation of spider veins.

How to drink Janine?

Perhaps the main feature of the use of Janine, however, like all contraceptives, is a certain scheme of use. You cannot start drinking them any day of your own free will. Moreover, if you take such pills, you should not throw them away halfway through the package.

It is better to take Janine at the same time of day. This way, your body will quickly get used to the incoming hormones, which means the likelihood of developing side effects will be lower. According to the instructions, you need to start drinking Janine if:

• In the previous month you did not take other hormonal contraceptives, then on the first day of your next period.
• In the previous month, you took a contraceptive, the package of which contained 28 tablets, or used a hormonal patch or ring, then you should take the first tablet the next day, after the end of taking the drug or the effect of the ring or patch. That is, in this case you should not have any break.
• In the previous month, you took a hormonal contraceptive containing 21 tablets. Then you need to start taking Janine after a seven-day break. If before this you were protected with drugs containing gestagens, for example, injection drugs Norplant, Depo-Provera or mini-pills, such as Charozetta or Excluton, then you need to take Janine without interruption.
• After an abortion or childbirth, the drug should be taken as prescribed by a doctor, who will select the optimal day for this.

Janine is a drug containing synthetic hormones and is available with a prescription. This means that it should be prescribed by a doctor who can take into account all the characteristics of your body.

Taking hormonal contraceptives requires attention, especially if you are starting to take such a drug for the first time. Don't forget to take your next pill on time, be sure to follow the instructions and follow your doctor's recommendations.

Janine, a drug that is essential for a woman’s health. The instructions for use describe all its advantages from contraceptive action to restoration of pathological hormonal imbalance.

Release form and cost

1. Tablets:

2. Dragee:

• round in shape, milky in color, covered with a gelatin shell;
• the price of Janine dragees varies from 1020 rubles. up to 2700 rub. for 1 package.

Compound

Janine (instructions for use of tablets and dragees contain the names of its constituent elements) has the following composition:

1. tablets:

• ethylestrateriene diol;
• a progestin available in combination with estrogen – dienogest;
• carbohydrate of the disaccharide group;
• carbohydrate polymer, transparent paste – corn starch;
• incompletely fermented hydrolyzed starch - molasses;
• cane sugar;
• aqueous concentrate of monosaccharides;
• polyethylene glycol;
• wax from Brazilian palm leaves;
• amphoteric titanium oxide;

2. dragees:

• ethinyl estratriene diol;
• progestin, in combination with estrogen;
• milk sugar;
• potato leucoplasts;
• hydrolyzed collagen protein;
• silicate mineral;
• magnesium salt and stearic acid;
• cane disaccharide;
• grape sugar;
• polyethylene glycol;
• carbonic acid and calcium salt;
• polyvinylpyrrolidone;
• tetravalent titanium;
• palm waxy substance.

Advantages of the drug

The drug Janine is a complex drug consisting of hormones for planning pregnancy and treating inflammatory hormonal imbalance in a woman’s body.

The value of the medicine Janine lies in the following action:

Disadvantages of the drug

Janine (the instructions for use do not describe the disadvantages of the drug) has special instructions that should be followed:

Medicinal properties

The drug Janine has medicinal properties and is used for many pathological conditions of the body:

• acute and chronic diseases of the ovaries, uterine cavity, paired tubes that connect the female organs;
• with low hemoglobin;
• prevents the formation of tumors in the ovaries and uterus;
• treats some forms of mastopathy;
• used in the treatment of acne;
• with diffuse baldness;
• the drug Zhanine reduces the functioning of the exocrine glands, which helps treat seborrhea;
• strengthens bones;
• treats pathological fragility of bones due to impaired metabolic processes;
• relieves pain in the mammary glands during mastopathy;
• relieves premenstrual edema.

Indications for use

Janine (instructions for use explain that first of all this drug is an oral contraceptive) has indications for the following diseases:

Contraindications for use

Janine, like any pharmacological agent, has contraindications, which are described in the instructions for use:

Side effects and overdose

The instructions for use of the drug Janine describe the side effects that you may encounter while taking this medicine.

1. Infections:

• mucous inflammatory process in the vagina;
• vaginal candidiasis;
• inflammation of the ovaries and tubes;
• cystitis;
• inflammation of the cervix;
• herpetic lesions of the oral cavity;
• inflammation of the bronchi;
• sinusitis;
• flu.

2. Tumors of unknown etiology:

• fibroids;
• fatty breast tumor;

3. Blood and lymph:

• decrease in hemoglobin.

4. Immunity:

• allergic reactions;
• autoimmune pathologies.

5. System of endocrine glands:

• Manifestation of male characteristics in women (hair growth, deepening of the voice).

6. Metabolic processes:

• increased desire to eat;
• psycho-emotional disorder due to excess weight.

7. Mental disorders:

8. Neurological disorders:

• migraine pain;
• violation of movement coordination;
• cerebral hemorrhages;
• encephalopathy;
• syndrome of nervous excitability disorder.

9. Visual system:

• Sjögren's syndrome;
• redness of the eye membranes;
• escillopsia;
• decreased vision.

10. Hearing aid:

11. Cardiac system:

• increased blood pressure;
• lowering blood pressure;
• arrhythmia.

12. Vascular system:

• varicose veins;
• Raynaud's disease;
• thrombosis of veins and arteries.

13. Organs of the chest:

• respiratory failure;
• decrease in the level of carbon dioxide in the blood.

14. Abdominal cavity:

• inflammation of the stomach;
• intestinal inflammation;
• stool disorder;
• urge to vomit;
• nausea.

15. Skin:

16. Connective tissue system:

• lower back pain;
• pain in the body and joints;
• muscle inflammation;
• pain in arms and legs.

17. Reproductive system:

• chest pain;
• bleeding of unknown etiology;
• swelling;
• vaginal leucorrhoea;
• pain in the uterine cavity;
• diffuse damage to the mammary glands.

18. Disorders:

• fatigue;
• general swelling;
• local swelling.

19. Research:

• weight gain;
• increased levels of cholesterol and glucose in the blood;
• weight loss.

20. Genetic pathologies:

• the appearance of excess mammary glands.

Overdose symptoms

Severe symptoms of exceeding the permissible dose of the drug Janine are unlikely.

They can only appear in hormonally immature girls in the form of:

This condition does not require special treatment. In rare cases, it is necessary to rinse the stomach and use enterosorbents.

How to switch to taking the drug from other contraceptives

Janine (the instructions for use provide clear and understandable recommendations) requires a special transition to this drug from other means that protect against unwanted pregnancy.

1. Changing oral contraceptives:

• It is imperative to take the drug Janine the next day after taking another type of pharmacological agent.

2. Changing the latex ring and TTS:

• It is necessary to take the tablet or dragee Janine on the day when the latex ring or TTC was removed, but no later than the next day.

Choosing the first day of admission

If the body has not taken any contraceptive medications, then you need to start taking the drug Janine from the 2-4th day of the monthly cycle.

Prescription in case of change in the onset of the menstrual cycle

If there is a violation of the menstrual cycle, then it is necessary to exclude a possible pregnancy.

In case of a negative test, you need to take Janine’s medicine until the start of a new cycle, and drink the drug 2-4 days after the return of menstruation.

In case of violation of the dosage regimen

There are certain rules according to which you need to take the drug Janine.

If you miss a medication dose, you must:

1. At 1 – 2 weeks you need to take the forgotten dose of the drug. You can take several tablets or pills at once. After that, you need to use the drug as prescribed according to the instructions. But in the next week you need to use a condom during sexual relations.

2. At 3 weeks. The danger of falling protection and the occurrence of unwanted pregnancy, after a week's break in the use of the drug Janine, the following occurs very acutely:

• you need to take a forgotten dose of medicine and need to take several pills or tablets. Then continue therapy as usual according to the regimen. There should be no breaks between the plates of the drug. There may be slight bleeding from the vagina after starting the next plate. This shouldn't be alarming.
• There is another option for taking the medicine if you miss it in the third week. It is necessary to leave the use of Janine from the remaining plate. In this situation, the period of absence of the drug Janine should not be a week.

Further use of tablets or dragees should be continued with the next tablet of the drug. In the absence of bloody discharge, which is mandatory if the regimen for using the drug Janine is violated, an unwanted pregnancy may occur.

Rules for admission after childbirth or abortion

There are certain rules for taking the drug Janine after childbirth and abortion:

Selection of drug by age

The drug Janine does not require special dosage selection according to age. The only exception is that this drug does not need to be used during the postmenopausal period.

Instructions for use

Zhanine tablets or dragees must be consumed according to the scheme - 1 pc. per day, constantly, at approximately equal intervals. If necessary, drink it with a small amount of water. The medicine must be taken every day in a row for 21 days, without omissions or breaks.

The use of dragees or tablets from the subsequent plate should be started after a week's rest. During this period there will be bleeding without stopping. This type of bleeding, starting 2-3 days after the last dose of the medicine from the plate, will end with the start of a new three-week course of contraceptive therapy.

Janine and endometriosis

The drug Janine is a combination medicine that is not only a contraceptive, but is also used for the growth of connective tissue of the uterine cavity - endometriosis.

One of the components of the drug Janine is a progestin in combination with estrogen. This combination affects the unnatural growth of endometrial connective tissue, stopping it.

For pathologies of the uterine cavity, Janine’s tablets or dragees must be used according to a special regimen - it is called “long-term”. What distinguishes Janine from the usual use of the drug is the continuous use of pills or tablets for 63 days.

During therapy it is necessary to consume 3 tablets of the medicine. Then you need to rest for a week. With this type of treatment, there will be no menstrual cycle for the entire 3 months.

Scheme for using the drug for uterine fibroids

Fibroids should be treated with Janine if certain rules are followed. Tablets or pills should be used for 3 months without interruption.

Every day you need to drink 1 pill or tablet at a certain time. For therapy, 3 tablets of the drug are required. After the course of therapy, you need to take a week's rest. During this period there will be bleeding associated with the menstrual cycle.

In the future, it is necessary to conduct a follow-up examination. If necessary, the course of therapy is extended for an additional 90 days.

Why is Janine prescribed after surgery to remove fibroids?

As a rule, during surgical treatment of all types of fibroids, the uterus must be removed. Therefore, the prescription of the drug Janine is necessary to restore hormonal imbalance.

The effectiveness of drug treatment

The decision to treat with Zhanine is made only by a doctor, in accordance with the examination and the presence of chronic pathologies.

It is necessary to use Janine only either until the lump has grown to 2 cm, or in the postoperative period, as hormone replacement therapy.

The effectiveness of using the drug Janine is high, within 80%. But treatment should be carried out only as prescribed and under the supervision of a doctor.

Analogs of the drug Janine

The drug Janine has analogues or drugs with a corresponding effect and composition.

1. Tablets Silhouette:

2. Naadin tablets:

• The drug contains progestin, estradiol, polyvinylpyrralidone, milk sugar, ethylene glycol polymer, amphoteric titanium oxide, thermoplastic polymer, corn starch paste, molasses, carbonic acid and calcium salt
• Naadin tablets must be used as a systemic oral contraceptive drug;
• the price for this type of tablet varies from 410 rubles. up to 580 rub.

The hormonal drug Zhanine in the instructions for use is described as a modern, effective, contraceptive drug, which, if used correctly, can protect not only from unwanted pregnancy, but also cure hormonal imbalance and its consequences, such as fibroids and the proliferation of endometrial connective tissue.

Article format: Vladimir the Great

Video about Zhanine tablets and other contraceptive drugs

Hormonal contraception. What is this:

Content

To prevent unwanted pregnancy and for drug therapy of gynecological pathologies, the contraceptive drug Janine is used. The medication belongs to the group of combined oral contraceptives with a low dosage of estrogens. Pills with a contraceptive effect Janine - instructions for use are in each package - are prescribed to prevent ovulation and normalize the menstrual bleeding cycle.

Birth control pills Janine

The drug Janine is a low-dose oral combined hormonal drug. The contraceptive effect is achieved through special complementary mechanisms, one of which is the suppression of ovulation and an increase in the viscosity of cervical mucus, as a result of which the cervical canal becomes impermeable to sperm.

When the pill is used correctly, the rate of unwanted pregnancy is less than 1 in 100 women who took this hormonal contraceptive for a year. In girls who took combined oral contraceptives (COCs), the menstrual cycle becomes more regular, pain is less common, and the intensity and duration of bleeding are significantly reduced. In addition, there is clinical evidence of a reduced risk of endometriosis, ovarian and cervical cancer.

Composition and release form

The drug is available in the form of biconvex tablets, white, pale yellow or cream in color. The tablets are placed in a plastic blister of 28 pieces and in a cardboard package with instructions for use of the medication. Compound:

Pharmacodynamics and pharmacokinetics

After oral administration, the drug is quickly and completely absorbed from the gastrointestinal tract, the maximum concentration of the active component in the blood plasma is reached after approximately 2-3 hours. Bioavailability is about 90%. The components of the drug bind to serum proteins by 80%. The medication Janine is completely metabolized by liver enzymes. The half-life is approximately 10-12 hours. A small amount unchanged is excreted by the kidneys in the urine.

Indications for use

Contraceptives Zhanine are indicated for use by women and girls of fertile age to prevent unwanted pregnancy, reduce the symptoms of premenstrual syndrome, equalize hormonal levels and resume regular cycles in various systemic endocrine pathologies. The medication is prescribed for the treatment of functional ovarian cysts, for the treatment of secondary infertility, and cervical cancer.

When taking Zhanine to prevent pregnancy, you must remember that this method of contraception does not protect against sexually transmitted diseases (HIV infection, hepatitis, chlamydia, etc.). If you do not have a permanent sexual partner or if your spouse has bacterial and viral sexually transmitted diseases, it is strongly recommended to use barrier contraceptive methods (condoms).

How to drink Janine

To achieve a contraceptive effect, Janine's medication must be taken orally for 21 days in the order indicated on the package, daily, with a small amount of water or any other drink (except alcohol-containing drinks). Taking tablets from the next package must be started after a 7-day break, during which withdrawal bleeding occurs, similar to menstruation. Normally, menstrual flow begins 2-3 days after taking the last pill and lasts 5-7 days.

If you miss a pill, you need to take two tablets the next day and then take the drug according to the previous regimen. In this case, spotting may occur for several days. If after taking the medicine for 3-4 hours a woman has vomiting or diarrhea, then she should take another tablet, because absorption of the drug components may be insufficient.

How to take Janine for the first time

The initial use of Zhanine or its use after an artificial or spontaneous abortion to establish a cycle must be carried out on the first day of menstruation (even with irregular bleeding). Sometimes it is allowed to start taking pills on the 2-3rd day of the cycle, but it is necessary to additionally use a barrier method of contraception during the first week of using the pills from the first package.

special instructions

During pharmacological therapy with drugs that affect microsomal enzymes, and for 30 days after discontinuation, it is necessary to additionally use a barrier method of contraception. When using antibiotics, it is also necessary to take additional precautions. In addition, the medication should be discontinued to prevent the risk of thrombosis during and immediately after elective surgery. You should take Zhanine birth control pills with caution in the following cases:

• lipid metabolism disorders;
• excess sex hormones;
• arterial thromboembolism;
• epilepsy;
• migraine;
• autoimmune diseases;
• renal or liver failure;
• anemia;
• colitis;
• hypertension.

During pregnancy

Janine is contraindicated for use during pregnancy and lactation. If pregnancy is detected while using the medicine, then taking the tablets should be stopped. However, large-scale clinical and epidemiological studies have not revealed any correlation between the increased risk of pathologies in children who were exposed to hubbub during fetal development.

Alcohol compatibility

The simultaneous use of ethyl alcohol and contraceptive drugs significantly reduces the normal absorption of the latter, so tablets should not be taken less than 3-4 hours before drinking alcohol and earlier than 2-3 hours after. In addition, alcohol-containing drinks contribute to the frequent development of side effects (especially thrombosis, nausea, migraines).

Drug interactions

Long-term therapy with drugs that induce liver enzymes can lead to severe breakthrough bleeding from the uterus and a decrease in the effectiveness of the contraceptive drug Janine. When used simultaneously with antibiotics, the intrahepatic circulation of estrogens decreases and the concentration of estradiol, which has a contraceptive effect, decreases. Oral combination hormonal drugs may affect the metabolism of other drugs.

Side effects of Janine

With long-term use of a contraceptive or with individual intolerance to the drug, the following side effects of Zhanine are observed:

• soreness of the mammary glands;
• spotting and breakthrough uterine bleeding;
• headache;
• vaginal breakthrough bleeding;
• venous hypertension;
• early menopause;
• migraine;
• change in libido;
• dyspepsia (nausea, vomiting, diarrhea, constipation);
• fluid retention, tissue swelling;
• weight gain;
• allergies.

Contraindications

Zhanine tablets are a hormone-containing drug, so they can significantly affect the functioning of almost all organs and systems. The medication should be taken only if there are no contraindications for use. It is prohibited to use the medication under the following conditions:

• vascular thrombosis;
• arterial thromboembolism;
• atherosclerotic lesion;
• pancreatitis;
• liver tumors;
• malignant neoplasms;
• endocrine disorders;
• individual hypersensitivity to the components of the drug.

Terms of sale and storage

The drug must be stored in a dry, cool place, protected from direct sunlight, out of reach of small children and animals. Janine is available from pharmacies without a doctor's prescription.

Analogues of Janine

Medicines with a similar composition and effect are prescribed in cases where Zhanine tablets are contraindicated for use by a sick patient. The following medications are identified on the pharmaceutical market, identical in properties to Janine:

1. Dimia. Zhanin's analogue is used for contraceptive and cosmetological effects. Thanks to this medicine, the condition of the skin, nails, and hair improves. In addition, women report a decrease in the manifestations of premenstrual syndrome.
2. Lendinet-20. The medicine is prescribed, as a rule, to adolescents, because has a significantly lower concentration of the active component and rarely causes side effects even with long-term use. The medication is indicated for violations of the frequency, duration and regularity of menstruation.

Price Janina

The cost of the medicine depends on the form of the drug, the degree of purification, the quality of the main active substance and auxiliary components. The price of the drug may be influenced by the region and pharmacy in which it is sold. The cost of the medicine can be set by the manufacturer. The approximate price of the medicine in Moscow is indicated in the table.

Janine is a monophasic drug that has a contraceptive effect. The composition combines unique components (artificial analogues of female hormones) that prevent the onset of unplanned pregnancy.

The drug helps regulate the menstrual cycle, as well as eliminate intermediate bleeding and pain, especially with irregular and heavy menstrual bleeding (which can lead to everything else anemia).

In this article we will look at why doctors prescribe the drug Zhanine, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Janine, leave your feedback in the comments.

Release form and composition

The drug is produced in the form of white smooth tablets, every 21 of which are packaged in blisters. One or three blisters are included in a cardboard pack of the drug.

Each dragee contains:

• active ingredients: 0.03 mg ethinyl estradiol and 2.0 mg dienogest.
• excipients: lactose monohydrate, potato starch, gelatin, talc, magnesium stearate, sucrose, sugar syrup, polyvidone K 25, macrogol 35000, calcium carbonate, titanium dioxide (E 171), carnauba wax.

Clinical and pharmacological group: monophasic oral contraceptive with antiandrogenic properties.

What is Janine used for?

According to the instructions, Zhanine is recommended to be taken by women who have regular sex life to prevent unwanted pregnancy. In addition, in medical practice, Zhanine tablets are often used as the main and auxiliary treatment for the following conditions and diseases:

• endometriosis;
• reproductive dysfunction;
• dysmenorrhea (painful menstruation);
• amenorrhea (lack of menstruation);
• menorrhagia (heavy menstruation);
• the period after gynecological surgical interventions (for the purpose of recovery after surgery and consolidation of its results);
  increased levels of male sex hormones in a woman’s blood (which often results in acne, very oily skin, and excessive hair growth of the skin).

pharmachologic effect

The contraceptive effect of Janine is carried out through complementary mechanisms, the most important of which include suppression of ovulation and a change in the viscosity of cervical mucus, as a result of which it becomes impermeable to sperm.

When used correctly, the Pearl index (an indicator reflecting the number of pregnancies in 100 women taking a contraceptive during the year) is less than 1. If pills are missed or used incorrectly, the Pearl index may increase.

In women taking combined oral contraceptives, the menstrual cycle becomes more regular, painful menstruation is less common, the intensity and duration of bleeding decreases, resulting in a reduced risk of developing iron deficiency anemia. In addition, there is evidence of a reduced risk of endometrial and ovarian cancer.

Instructions for use

The pills should be taken orally in the order indicated on the package, every day at approximately the same time, with a small amount of water. Janine should be taken 1 tablet/day continuously for 21 days. Each subsequent package begins after a 7-day break, during which withdrawal bleeding (menstrual-like bleeding) is observed. It usually begins on the 2-3rd day after taking the last pill and may not end until you start taking a new package.

• How to start taking Janine if you have not taken any hormonal contraceptives in the previous month. Taking Janine begins on the first day of the menstrual cycle (i.e., on the first day of menstrual bleeding). It is allowed to start taking it at 2-5 menstrual cycles, but in this case it is recommended to additionally use a barrier method of contraception during the first 7 days of taking pills from the first package.
• When switching from combined oral contraceptives, a vaginal ring, or a transdermal patch, taking Zhanine should begin the day after taking the last active pill from the previous package, but in no case later than the next day after the usual 7-day break in taking (for drugs containing 21 tablets) or after taking the last inactive tablet (for drugs containing 28 tablets per package). When switching from a vaginal ring or transdermal patch, it is preferable to start taking Janine on the day the ring or patch is removed, but no later than the day when a new ring is to be inserted or a new patch is applied.
• When switching from oral contraceptives containing only gestagen (mini-pills), you can stop taking the mini-pill on any day and start taking Zhanine the next day at the same time. During the first 7 days of taking the pills, you must also use an additional barrier method of contraception.
• When switching from an injectable contraceptive, an implant, or from a progestogen-releasing intrauterine contraceptive (Mirena). Start taking Janine on the day your next injection is due or on the day your implant or intrauterine device is removed. During the first 7 days of taking the pills, you must also use an additional barrier method of contraception.
• After an abortion in the first trimester of pregnancy. A woman can start taking the drug immediately. If this condition is met, the woman does not need additional contraceptive protection.
• After childbirth or abortion in the second trimester of pregnancy, it is recommended to start taking the drug on the 21-28th day after childbirth or abortion in the second trimester of pregnancy. If use is started later, it is necessary to use an additional barrier method of contraception during the first 7 days of taking the pill. However, if a woman has already been sexually active, pregnancy should be excluded before taking Zhanine or she must wait until her first menstruation.

If no more than 12 hours have passed since you missed taking the pill, the contraceptive effect of the drug is not reduced. It is necessary to take the missed pill as soon as possible. Next, switch to the normal reception mode.

Taking missed pills

If the gap exceeds 12 hours, then contraceptive protection is reduced. There are two basic rules you should know:

1. You cannot stop taking the pills for more than 7 days.
2. Over the course of 7 days of continuous use of the pills, adequate suppression of the hypothalamic-pituitary-ovarian system is achieved.

• 1 Week. The last missed pill should be taken as soon as possible. Even if you have to take two pills at a time. Then continue to take the pills at the usual time. Over the next 7 days, it is recommended to use an additional method of protection, such as a condom. If sexual intercourse took place in the previous 7 days, the possibility of pregnancy should not be ruled out. The closer the break in taking the drug and the more tablets missed, the higher the risk of pregnancy.
• Week 2. A woman should take the last pill she missed as soon as she remembers (even if this means taking two pills at the same time). The next pill is taken at the usual time. Provided that the woman took the pill correctly during the 7 days preceding the first missed pill, there is no need to use additional contraceptive measures. Otherwise, as well as if you miss two or more pills, you must additionally use barrier methods of contraception (for example, a condom) for 7 days.
• Week 3. As the break in taking the pills approaches, unreliability increases. But if you follow the dosage regimen, a decrease in contraceptive protection can be avoided. The need to use additional contraceptives will not arise if you adhere to one of the following options, if there were no violations in taking pills for 7 days before the missed dose. The recommendations of the following options should be explored. If there were violations before. then take additional protection for the next 7 days.

You can stop taking the pills from the current package. In this case, including days missed, the break in taking the drug should be up to 7 days. You need to start taking the pills with a new package. If there are disturbances from the gastrointestinal tract, then absorption of the drug will not be complete, which means that additional means of protection must be used. It is advisable to skip taking the pill if vomiting occurs within 3-4 hours after taking it. If you do not want to change your usual regimen of taking the drug, then you need to take additional pill(s) from a different package.

To delay the appearance of menstruation, there is no need to take a break from taking the drug, but continue taking the drug from a new package. Reception can be continued until the end of the second package. Bloody or breakthrough bleeding cannot be ruled out. After a 7-day break, the usual use of the drug Janine is restored.

To shift the onset of menstruation to another day of the week, it is recommended to reduce the break in taking the pills by the required number of days. The duration of the break affects the absence/presence of menstrual-like bleeding and breakthrough or bloody bleeding.

Contraindications

Janine should not be used if you have any of the conditions/diseases listed below. If any of these conditions develop for the first time while taking it, the drug should be discontinued immediately.

1. Bleeding from the vagina of unknown origin.
2. Pregnancy or suspicion of it.
3. Breastfeeding period.
4. Conditions preceding thrombosis (including transient ischemic attacks, angina) currently or in history.
5. Migraine with focal neurological symptoms currently or in history.
6. Diabetes mellitus with vascular complications.
7. Pancreatitis with severe hypertriglyceridemia, currently or in history.
8. Liver failure and severe liver disease (until normalization of liver tests).
9. Liver tumors (benign or malignant) currently or in history.
10. Identified hormone-dependent malignant diseases (including genital organs or mammary glands) or suspicion of them.
11. Multiple or severe risk factors for venous or arterial thrombosis, including complicated lesions of the heart valve apparatus, atrial fibrillation, cerebrovascular disease or coronary artery disease; uncontrolled arterial hypertension, major surgery with prolonged immobilization, smoking over the age of 35 years.
12. Thrombosis (venous and arterial) and thromboembolism currently or in history (including deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke), cerebrovascular disorders.

Side effects

Soreness and tension of the mammary glands, enlargement of the mammary glands, discharge from the mammary glands; spotting and breakthrough uterine bleeding; headache; visual impairment; nausea; vomit; stomach ache; changes in vaginal secretion; skin rash; erythema nodosum; migraine; change in libido; decreased/changes in mood; poor tolerance to contact lenses; erythema multiforme; generalized itching; cholestatic jaundice; fluid retention; change in body weight; allergic reactions.

Rarely - increased levels of plasma triglycerides, decreased tolerance to carbohydrates, increased fatigue, diarrhea. As with other combined oral contraceptives, in rare cases the development of thrombosis and thromboembolism is possible.

Changing the start day of the menstrual cycle

To delay the onset of menstruation, a woman should continue taking pills from a new package of Janine immediately after taking all the pills from the previous one, without interruption. The pills from this new package can be taken for as long as the woman wishes (until the package runs out). While taking the drug from the second package, a woman may experience spotting or breakthrough uterine bleeding. You should resume taking Janine from a new package after the usual 7-day break.

To move the start of menstruation to another day of the week, a woman should shorten the next break in taking the pills by as many days as she wants. The shorter the interval, the higher the risk that she will not have withdrawal bleeding and will continue to have spotting and breakthrough bleeding while taking the second package (the same as in the case when she would like to delay the onset of menstruation).

If a woman has vomiting or diarrhea within 4 hours of taking active tablets, absorption may not be complete and additional contraceptive measures should be taken. In these cases, you should follow the recommendations when skipping pills.

special instructions

The use of the drug Zhanine is contraindicated before the onset of menarche and after the onset of menopause.

In some cases, the use of sex hormones can cause the development of tumors in the liver. An increase in the size of the liver, severe abdominal pain, as well as signs of intraperitoneal bleeding must be taken into account when making a differential diagnosis.

Taking the drug Janine may be accompanied by irregular bleeding (both in the form of spotting and breakthrough bleeding), especially in the first months of therapy. In this regard, assessment of irregular bleeding should be carried out only after an adaptation period of approximately 3 cycles.

If such bleeding recurs or occurs after previous regular cycles, a non-hormonal cause should be sought. Diagnosis is carried out to exclude the presence of a malignant neoplasm or pregnancy in the patient. In some cases, diagnostic curettage may be required.

Janine does not protect against STDs and HIV infection.

Analogs

Analogues of Zhanin by mechanism of action: Belara, Yarina, Dayla, Midiana, Jess, Logest, Evra, Lindinet 30, Mercilon, Marvelon, Egestrenol, Femoden, Oralcon, Dimia.

Prices

The average price in pharmacies (Moscow) is 1178 rubles.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life – 3 years.

Manufacturer: Bayer HealthCare Pharmaceuticals (Bayer Healthcare Pharmaceutical) Germany

ATC code: G03AA

Farm group:

Release form: Solid dosage forms. Dragee.

General characteristics. Compound:

Pharmacological properties:

Indications for use:

Important! Learn about contraception treatment

Directions for use and dosage:

Features of application:

Side effects:

Interaction with other drugs:

Contraindications:

Overdose:

Storage conditions:

Store at a temperature not exceeding 25 °C. Keep out of the reach of children. Shelf life: 3 years. Do not use after expiration date!

Vacation conditions:

On prescription

Package:

Dragee. 21 tablets per blister made of polyvinyl chloride film and aluminum foil. 1 or 3 blisters along with instructions for use are placed in a cardboard box.