Galavit tablets analogues are cheaper. Method of application and dosage. Use in children

Tradename:

INN or grouping name:

Aminodihydrophthalazinedione sodium

Chemical Name:

5-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione sodium salt.

Dosage form:

Compound:

Description:
Suppositories from white to white with a yellowish tint, torpedo-shaped without visible inclusions on a longitudinal section.

Pharmacotherapeutic group:

ATX code: L03, G02.

Pharmacological properties:

Pharmacokinetics:
It is excreted from the body mainly through the kidneys. After rectal administration, the elimination half-life is 40-60 minutes. The main pharmacological effects are observed within 72 hours.

Indications for use:

Contraindications.

Dosage and administration:

Among the wide variety of immunomodulating agents on the modern pharmaceutical market, Galavit is distinguished.

This is a domestic drug that has been successfully used over the past 15 years in many branches of medicine. Suppositories used in gynecology deserve special attention.

On this page you will find all the information about Galavit: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Galavit suppositories. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Immunomodulatory drug.

Terms of dispensing from pharmacies

Released without a prescription.

Prices

How much does Galavit cost in the form of candles? The average price in pharmacies is at the level of 800 rubles.

Release form and composition

Candles Galavit rectal have a white or yellowish-white hue, torpedo-shaped, no visible inclusions. They are sold in cellular contour packaging, a package of 10 suppositories is enclosed in a cardboard box.

• In one rectal suppositories contains 0.1 g galavita , additional substances.

Pharmacological effect

After the introduction of the suppository into the rectum, there is a rapid (within 20 minutes) absorption of the drug into the systemic circulation. The active substance penetrates well into all functional tissues of the body and acts at the local level:

• normalizes antibody formation, and activates T-cell immunity;
• has an indirect effect on the production of endogenous interferons - substances that can fight foreign antigens;
• affects the phagocytic activity of neutrophils and macrophages: the ability of immune cells to capture and destroy pathogen cells increases;
• produces a reversible blocking of the production of inflammatory markers (cytokines, tumor necrosis factor and others).

The above effects are valid for 68-72 hours after administration. The drug has an average bioavailability (61%). Metabolites of Galavit are excreted mainly through the kidneys.

Indications for use

Galavit is used for prevention and pathogenetic treatment:

1. Traumatic osteomyelitis;
2. Inflammatory diseases of the gastrointestinal tract (and, nonspecific ulcerative colitis, etc.);
3. Inflammatory diseases of the urogenital area (, pyelitis, etc.);
4. Inflammatory diseases of the urogenital area (salpingitis, vaginitis, etc.);
5. Ear infections (, dysentery, food poisoning and other diseases accompanied by diarrheal syndrome);
6. Reduced sexual function, which is based on a violation of microcirculation;
7. Infectious diseases (septic conditions of various etiologies, hepatitis, purulent meningitis);
8. Bronchopulmonary diseases (, including with,);
9. Immunodeficiency states, as well as for the correction of immunity in cancer patients in the pre- and postoperative period, receiving radiation and chemotherapy;
10. Various vascular disorders (diabetic angiopathy, endarteritis and related complications, ischemic angiopathy of various organs);
11. Chronic inflammatory diseases (including those with allergic and autoimmune components in the pathogenesis - liver damage of various etiologies, scleroderma, endometritis, etc.);
12. Prevention of postoperative complications.

Contraindications

Contraindications to the use of the drug are hypersensitivity to the constituent substances, pregnancy and lactation.

Use during pregnancy and lactation

Treatment with a woman's drug is contraindicated throughout pregnancy and during breastfeeding.

Instructions for use

The instructions for use indicate that Galavit suppositories are used rectally. The suppository is released from the contour packaging and then injected into the rectum. It is recommended to first empty the intestines. The dose and duration of the drug depends on the nature, severity and duration of the disease.

Suppositories 50 mg are intended for children aged 6-12 years:

1. To improve physical performance - 1 supp. in one day; course - 5 supp.
2. With peptic ulcer of the stomach and duodenum in the acute period - in the first 2 days, 2 supp. 1 time / day, then 1 supp. with an interval of 72 hours Course - 15-25 supp. In the chronic period - within 5 days, 1 supp. 1 time / day, then 1 supp. after 72 hours Course - 20 supp.
3. In acute infectious intestinal diseases accompanied by diarrheal syndrome, the initial dose is 2 supp. once, then 1 supp. 2 times / day until relief of symptoms of intoxication. Perhaps the subsequent continuation of the course of 1 supp. with an interval of 72 hours Course - 20 supp.
4. In chronic recurrent diseases caused by the herpes virus, appoint 1 supp. daily for 5 days, then 1 supp. every other day - 15 supp.
5. In viral hepatitis, the initial dose is 2 supp. once, then 1 supp. 2 times / day until relief of symptoms of intoxication and inflammation. Subsequent continuation of the course - 1 supp. with an interval of 72 hours Course - 20 supp.
6. In diseases caused by the human papillomavirus, 1 supp is prescribed for 5 days. 1 time / day, then 1 supp. in one day. Course - 20 supp.
7. In asthenic conditions, neurotic and somatoform disorders - within 5 days, 1 supp. daily, then 1 supp. after 72 hours Course - 15 supp.
8. In case of purulent surgical diseases (burn lesions, recurrent furunculosis, chronic osteomyelitis, gangrenous appendicitis with omentitis, purulent pleurisy), 1 supp is prescribed. daily for 5 days, then 1 supp. every other day for 10 days.
9. In inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases, the initial dose is 1 supp. daily - 5 supp., then 1 supp. with an interval of 72 hours Course - 15 supp.
10. For the treatment and prevention of urogenital infections of bacterial and viral etiology, the drug is prescribed on the 1st day, 1 supp. 2 times / day, then 1 supp. in one day. Course 10-15 supp. (depending on the severity of the pathological process).
11. For the prevention and treatment of surgical complications in the pre- and postoperative period (including in oncological patients), 1 supp is prescribed for 5 days before surgery. 1 time / day, 1 supp. one day after the operation (5 supp.) and 5 supp. - with an interval of 72 hours. In severe cases of the disease, the initial dose is 2 supp. once or 1 supp. 2 times/day Course - 20 supp.
12. With frequent recurrent diseases of the respiratory tract and ENT organs of bacterial and viral etiology (frequent SARS, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis) - 1 supp. daily for 5 days, then 1 supp. every other day for 10 days. Course - 15 supp.
13. For the prevention of influenza and acute respiratory infections - 1 supp. 1 time / day Course - 5 supp.

Suppositories 100 mg are intended for adults and adolescents over 12 years of age:

1. To improve physical performance - 1 supp. every other day - 5 supp., then - 1 supp. after 72 hours Course - up to 20 supp.
2. In chronic recurrent furunculosis, erysipelas - for 5 days, 1 supp. 1 time / day, then - 1 supp. in one day. Course - 20 supp.
3. With peptic ulcer of the stomach and duodenum in the acute period - 2 supp. 1 time / day for 2 days, then - 1 supp. with an interval of 72 hours. The course is 15-25 supp. In the chronic period - within 5 days, 1 supp. 1 time / day, then - 1 supp. after 72 hours. The course is 20 supp.
4. In acute intestinal infections accompanied by diarrheal syndrome, the initial dose is 2 supp. once, then - 1 supp. 2 times / day until relief of symptoms of intoxication. Perhaps the subsequent continuation of the course of 1 supp. with an interval of 72 hours. The course is 20-25 supp.
5. In viral hepatitis, the initial dose is 2 supp. once, then 1 supp. 2 times / day until relief of symptoms of intoxication and inflammation. Subsequent continuation of the course - 1 supp. with an interval of 72 hours. The course is 20-25 supp.
6. In diseases caused by the human papillomavirus, the drug is prescribed for 5 days, 1 supp. 1 time / day, then - 1 supp. in one day. The course is 20 supp.
7. In chronic recurrent diseases caused by the herpes virus, appoint 1 supp. daily for 5 days, then - 1 supp. every other day for 15 days.
8. With salpingoophoritis, endometritis in the acute period, 2 supp are prescribed for 2 days. 1 time / day, then - 1 supp. with an interval of 72 hours. In the chronic period - for 5 days, 1 supp. 1 time / day, then - 1 supp. every 72 hours. The course is 20 supp.
9. In acute and chronic purulent diseases of the pelvic organs - in the acute period, the drug is prescribed on the 1st day 2 supp. once, then for 3 days, 1 supp. daily, then - 1 supp. every other day for 5 days. Course - 10 supp. In the chronic period, the drug is prescribed for 5 days, 1 supp. 1 time / day, then - 1 supp. every 72 hours. The course is 20 supp.
10. For postoperative rehabilitation of patients with uterine myoma and complications of the postoperative period in patients of reproductive age - within 5 days, 1 supp. 1 time / day, then - 1 supp. in one day. Course - 15 supp.
11. For the prevention and treatment of surgical complications in the pre- and postoperative period (including in oncological patients), it is prescribed before surgery - for 5 days, 1 supp. 1 time / day, after surgery - 1 supp. every other day (5 supp.) and 5 supp. with an interval of 72 hours. In severe cases of the disease, the initial dose of the drug is 2 supp. once or 1 supp. 2 times/day Course - 20 supp.
12. With asthenic conditions, neurotic and somatoform disorders, with mental, behavioral and post-abstinence disorders, in patients with alcohol and drug addiction - within 5 days, 1 supp. daily, then - 1 supp. after 72 hours Course - 15-20 supp.
13. In inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases, the initial dose of the drug is 1 supp. daily for 5 days, then - 1 supp. with an interval of 72 hours Course - 15 supp.
14. With urogenital infections (chlamydial and trichomonas urethritis, chlamydial prostatitis) - on the 1st day, 1 supp. 2 times / day, then - 1 supp. in one day. The course is 10-15 supp. depending on the severity of the pathological process.
15. For non-specific prevention and treatment of influenza and acute respiratory infections - 1 supp. 1 time / day The course is 5 days.

Side effects

Galavit rarely has a negative effect on the body, in less than 0.1% of cases. Side effects include allergic reactions from the mucous membranes and skin: itching, redness, rash, urticaria.

Overdose

There are no data on drug overdose.

drug interaction

With the simultaneous use of this drug with antibacterial drugs, it is possible to reduce the dosage of the latter.

The drug "Galavit" and alcohol can be combined, but it is better not to abuse alcohol during treatment.

There is currently no information on interactions with other drugs.

Galavit is a domestic immunomodulator. Its name, which means "global life" in Latin, was born at the Medical Academy. I. M. Sechenov and fully corresponds to the purpose of the drug, the indications for the use of which can hardly fit in a standard leaflet. The active substance of Galavit - sodium aminodihydrophthalazinedione - is quite suitable for use as an unpronounceable tongue twister or for an exam in the casting of television announcers. It cannot be said that this drug is so widely known today that it seems absolutely undeserved: Galavit is, in fact, the only immunomodulator with reliably proven anti-inflammatory activity. For a brief acquaintance with the drug, it remains to add that it is relatively “young” and has been used in Russia since 1997.

The pharmacological group of immunomodulators is one of the most extensive and "multinational", including drugs of natural and synthetic origin. Galavit belongs to the latter. Its mechanism of action is due to the ability of the active substance of the drug to regulate the functional and metabolic activity of phagocyte cells (neutrophils, monocytes / macrophages, natural killers). Here it would be appropriate to dispel the terminological “fog” somewhat and talk about phagocytic cells. Neutrophils and monocytes are a type of white blood cell. The former account for 40-60% of all leukocytes. These are mature cells whose task is to surround and destroy foreign agents. Monocytes, which after their maturation are called macrophages, make up 3-8% of all leukocytes. They not only ingest bacteria, but also take part in immune reactions, in the production of antibodies, etc. Macrophages are activated under the influence of substances that are formed in the inflammatory focus.

In inflammatory diseases, Galavit temporarily (for 6-8 hours) suppresses the synthesis of alpha-tumor necrosis factor, the immune mediator of inflammation interleukin-1, and other inflammatory cytokines, excessively “hyped” by hyperactivated macrophages.

For reference: inflammatory cytokines are substances that ensure the interaction of immune cells in the midst of an inflammatory reaction and form the so-called. "inflammatory response". Normalization of the functional state of macrophages under the influence of Galavit reduces their level of autoaggression (direction of immune reactions against their own body). In addition, the drug directs the process of antibody production to the normal course, activates the formation of its own interferons. Galavit increases the body's resistance to diseases of an infectious nature: it has proven its effectiveness in the treatment of a number of bacterial and viral infections. The effect of the drug can be considered on the example of a severe sore throat, the signs of which are sore throat, swelling and hyperemia of the tonsils, an increase in body temperature to 39 ° C and above, etc. Despite the use of antibacterial agents, the disease is severe and can bloom with a whole "bouquet" of complications. The body “owes” the severity of the clinical picture to overly active macrophages, which, “excited” under the influence of inflammatory cytokines, “raised” the temperature bar to 39 ° C (while 37 ° C would have been enough according to the situation). Galavit will “restrain” the raging macrophages for 6 hours, while normally functioning macrophages, having gained access to the inflammatory focus, will destroy bacteria without too much fuss.

Galavit is available in three dosage forms: suppositories, powder for the preparation of an injection solution and sublingual tablets. Given the many indications for which the drug can be prescribed, it is best to get acquainted with its dosing regimen and features of administration from the leaflet or, more optimally, from the mouth of the attending physician.

Pharmacology

Immunomodulatory drug with anti-inflammatory action.

The mechanism of action is associated with the ability to influence the functional and metabolic activity of phagocytic cells (monocytes / macrophages, neutrophils, natural killers). In addition, Galavit ® normalizes antibody formation, indirectly stimulates the production of endogenous interferons (interferon-alpha, interferon-gamma).

In inflammatory diseases, it reversibly (for 6-8 hours) inhibits excessive synthesis by hyperactivated macrophages of tumor necrosis factor, interleukin-1, interleukin-6 and other pro-inflammatory cytokines, reactive oxygen species, the level of which determines the degree of inflammatory reactions, their cyclicity, as well as the severity of intoxication and levels of oxidative stress. Normalization of the functional state of macrophages leads to the restoration of the antigen presenting and regulatory functions of macrophages, and a decrease in the level of autoaggression.

The drug stimulates the bactericidal activity of neutrophilic granulocytes, enhancing phagocytosis and increasing the body's nonspecific resistance to infectious diseases.

The main pharmacological effects are observed within 72 hours.

Pharmacokinetics

Release form

Vials (3) - packs of cardboard.
Vials (5) - packs of cardboard.

Dosage

The dosage regimen and duration of therapy are set individually depending on the nature and severity of the disease, as well as on the age of the patient.

To prepare a solution for intramuscular injection, the drug in the form of a powder for solution for injection is diluted in 2 ml of water for injection or in 0.9% sodium chloride solution.

Adults and adolescents from 12 years of age (in the complex therapy of immunodeficiency states)

With peptic ulcer of the stomach and duodenum in the acute period - 2 days, 200 mg 1 time / day, then 100 mg with an interval of 72 hours. The course is 15-25 injections. In the chronic period - for 5 days, 100 mg 1 time / day, then - 100 mg every 72 hours. The course is 20 injections.

In viral hepatitis, the initial dose is 200 mg once, then 100 mg 2 times / day until the symptoms of intoxication and inflammation stop. The subsequent continuation of the course of therapy at a dose of 100 mg with an interval of 72 hours. The course is 20-25 injections.

In chronic recurrent herpetic infection, the drug is prescribed 100 mg daily 5 injections, then 100 mg every other day 15 injections.

In diseases caused by the human papillomavirus, the drug is prescribed for 5 days, 100 mg 1 time / day, then 100 mg every other day. The course is 20 injections.

In urogenital infections (chlamydial and trichomonas urethritis, chlamydial prostatitis), the drug is prescribed at 100 mg 2 times / day on the 1st day, then they switch to the administration of the drug at 100 mg every other day. The course is 10-15 injections, depending on the severity of the pathological process.

With salpingoophoritis, endometritis in the acute period, the drug is prescribed for 2 days, 200 mg 1 time / day, then 100 mg at an interval of 72 hours. The course is 20 injections. In the chronic period, the drug is prescribed for 5 days, 100 mg 1 time / day, then 100 mg every 72 hours. The course is 20 injections.

In acute and chronic inflammatory diseases of the pelvic organs in the acute period, the drug is prescribed on the 1st day 200 mg once, then for 3 days 100 mg daily, then 100 mg every other day 5 injections. Course - 10 injections. In the chronic period, the drug is prescribed for 5 days, 100 mg 1 time / day, then 100 mg every 72 hours. The course is 20 injections.

For postoperative rehabilitation of patients with uterine myoma and complications of the postoperative period in patients of reproductive age, the drug is prescribed for 5 days, 100 mg 1 time / day, then 100 mg every other day. The course is 15 injections.

For the prevention and treatment of surgical complications in the preoperative and postoperative period (including in cancer patients), the drug is prescribed 100 mg 1 time / day. Before surgery, 5 injections, after surgery, 5 injections of 100 mg every other day and 5 injections of 100 mg with an interval of 72 hours. In severe cases of the disease, the initial dose is 200 mg 1 time / day or 100 mg 2 times / day. Course - 20 injections.

In chronic recurrent furunculosis, erysipelas, 100 mg of the drug is prescribed 1 time / day for 5 days, then 100 mg every other day. Course - 20 injections.

In asthenic conditions, neurotic and somatoform disorders, with mental, behavioral and post-abstinence disorders, alcohol and drug addiction, the drug is prescribed for 5 days at 100 mg 1 time / day, then at 100 mg every 72 hours. The course is 15-20 injections .

To increase physical performance, the drug is prescribed 100 mg every other day for 5 injections, then 100 mg every 72 hours. The course is up to 20 injections.

In inflammatory diseases of the mucous membrane of the oral cavity and pharynx, periodontal diseases, the initial dose is 100 mg daily, 5 injections, then 100 mg every 72 hours. The course is 15 injections.

Adults and adolescents over 12 years of age (as monotherapy)

In acute and chronic infectious and inflammatory diseases of the gastrointestinal tract, accompanied by intoxication and / or diarrhea, 200 mg is prescribed once, then 100 mg 2 times / day until the symptoms of intoxication are relieved. Perhaps the subsequent continuation of the course of 100 mg with an interval of 72 hours. The course is 20-25 injections.

In chronic infectious and inflammatory diseases of the urogenital tract, incl. when carrying out immunorehabilitation measures in the interrecurrent period in order to maintain clinical remission, 100 mg every other day is prescribed. Course - 10 injections.

Children over 6 years of age

For purulent surgical diseases (including burn lesions, recurrent furunculosis, chronic osteomyelitis, gangrenous appendicitis with omentitis, peritonitis, purulent pleurisy), the drug is prescribed for children aged 6 to 11 years - 1 injection of 50 mg 1 time / day for 5 days, then 1 injection of 50 mg every other day for 10-15 days. The course is 10-15 injections. Children and adolescents aged 12 to 18 years are treated according to the same scheme in the form of intramuscular injections of 100 mg.

When dressings, it is desirable to use Galavit externally in the form of dressings with sterile wipes moistened with a 1% solution of Galavit in water for injection (in bandages with a talker or water-soluble ointment bandages).

With frequent recurrent diseases of the respiratory tract and upper respiratory tract of bacterial and viral etiology (frequent SARS, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis), children aged 6 to 11 years are prescribed 1 injection of 50 mg 1 time / day for 5 days, then - 50 mg 1 time / day every other day for 10-15 days. The course is 10-15 injections. Children and adolescents aged 12 to 18 years are treated according to the same scheme in the form of intramuscular injections of 100 mg.

Overdose

Interaction

Cases of incompatibility with other drugs have not been noted.

Side effects

Rarely: allergic reactions.

Indications

As an immunomodulator and anti-inflammatory agent in the complex therapy of immunodeficiency conditions in adults and adolescents from 12 years of age:

• peptic ulcer of the stomach and duodenum;
• viral hepatitis;
• chronic recurrent diseases caused by the herpes virus;
• diseases caused by the human papillomavirus (HPV);
• infectious and inflammatory diseases of the urogenital tract (urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis, acute and chronic salpingo-oophoritis, chronic endometritis);
• purulent-inflammatory diseases of the pelvic organs;
• postoperative rehabilitation of patients with uterine myoma;
• complications of the postoperative period in patients of reproductive age;
• postoperative purulent-septic complications and their prevention (including in cancer patients);
• chronic recurrent furunculosis, erysipelas;
• asthenic conditions, neurotic and somatoform disorders, decreased physical performance (including in athletes);
• mental, behavioral and post-withdrawal disorders in alcohol and drug addiction;
• inflammatory diseases of the mucous membrane of the mouth and throat, periodontal disease.

As monotherapy in adults and adolescents from 12 years of age:

• acute and chronic infectious and inflammatory diseases of the gastrointestinal tract, accompanied by intoxication and / or diarrhea;
• chronic infectious and inflammatory diseases of the urogenital tract, incl. when carrying out immunorehabilitation measures in the interrecurrent period in order to maintain clinical remission.

As an immunomodulatory and anti-inflammatory agent in the complex therapy of immunodeficiency conditions in children over the age of 6 years:

• purulent surgical diseases (including burn lesions, recurrent furunculosis, chronic osteomyelitis, gangrenous appendicitis with omentitis, peritonitis, purulent pleurisy);
• frequent recurrent diseases of the respiratory tract and ENT organs of bacterial and viral etiology (including frequent acute respiratory viral infections, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis).

Contraindications

• pregnancy;
• lactation period;
• children under 6 years of age (no clinical experience with the drug);
• individual intolerance.

Application features

Use during pregnancy and lactation

Use in children

special instructions

With simultaneous use with antibiotics, it is possible to reduce the course doses of the latter.

At the moment, pharmaceutical companies offer the consumer an extensive selection of various immunomodulatory drugs. A special place among them is occupied by the drug "Galavit". It is produced by a domestic manufacturer and has been used in many medical fields for 15 years. The Galavit candles, which are widely used in the field of gynecology, deserve the greatest attention. Detailed information will be provided on them.

Rectal suppositories "Galavit" belong to the group of immunomodulators. Dispensing from pharmacies is made without a prescription from a doctor.

In Russian pharmacies, the average cost of the drug fluctuates at the level of 850 rubles.

Compound

The drug is produced in three forms:

• In tablets, in the composition with sodium aminodihydrophthalazinedione 25 mg, as well as excipients such as lactose, talc, starch, calcium stearate, sorbitol, racementol.
• In powder for the manufacture of a solution with 50 or 100 mg of active ingredient in the composition.
• In the form of rectal suppositories, with the active ingredient 50 or 100 mg in the composition.

The instructions for candles "Galavit" are very detailed.

Pharmacological effects

After the introduction of the candle "Galavit" into the rectum, there is a rapid absorption of the active component into the systemic circulation. The active substance freely penetrates into all functional tissues of the body. The action of the drug is local:

1. Antibody formation is normalized, T-cell immunity is activated.
2. Indirectly affects the secretion of endogenous interferons, which are able to fight against foreign antigens.
3. Reversibly blocks the production of inflammatory markers (tumor necrosis, cytokines, etc.).
4. The phagocytic activity of macrophages and neutrophils increases - the ability of immune cells to capture and destroy pathogen cells is significantly increased.

The use of candles "Galavit" in gynecology is very popular.

The above effects work for about 70 hours after using the suppositories. The bioavailability of the drug is average, it is 61%. Metabolites are excreted mainly by the kidneys.

Indications for use

Candles "Galavit" can be used both for prevention and for the purpose of pathogenetic therapy of the following diseases and conditions:

1. Traumatic osteomyelitis.
2. Inflammatory pathologies of the gastrointestinal tract, including ulcerative lesions of the duodenum, stomach, ulcerative colitis with a nonspecific course, Crohn's disease.
3. Inflammatory diseases of the urogenital area, including urethritis, pyelonephritis, prostatitis, pyelitis.
4. Diseases of the inflammatory nature of the urogenital area, including vaginitis, salpingitis and others.
5. Intestinal infections, including food poisoning, dysentery, salmonellosis and other diseases that are accompanied by diarrhea.
6. Reduced sexual function against the background of microcirculation disorders.
7. Diseases of an infectious nature, including those with a different etymology of the state of sepsis, purulent meningitis, erysipelas, hepatitis.
8. Bronchopulmonary infections, including pneumonia, bronchitis, obstructive bronchitis, bronchial asthma.
9. immunodeficiency states. It can be used to correct immunity in cancer patients receiving chemotherapy and radiation therapy.
10. A variety of vascular disorders, including endarteritis and its complications, ischemic angiopathy of various organs, diabetic angiopathy.
11. Inflammation in a chronic form, including adnexitis, endometritis, rheumatoid arthritis, scleroderma, various etymologies of liver damage.
12. Prevention of complications that can develop after surgery.

Contraindications for use

Candles "Galavit" are strictly contraindicated in patients with individual sensitivity to the components that make up the suppositories. Also for women during pregnancy and while breastfeeding.

It is important to note that Galavit is contraindicated throughout the entire period of pregnancy, and not only in certain trimesters. However, rectal suppositories can be prescribed to a pregnant woman when the benefit to the mother outweighs the possible risk to the child.

Instructions for candles "Galavit"

Suppositories are intended for rectal administration. First, the candle must be removed from the contour package, and then inserted into the rectum. It is recommended to empty the intestines before the introduction of the suppository. The duration of the use of Galavit suppositories, as well as the required dosage, should be selected individually by the attending physician, taking into account the nature of the disease, its duration and severity.

"Galavit" with a dosage of 50 mg is intended for use in children aged 6-12 years:

• In order to increase physical performance, take 1 rectal suppository every other day. Duration - 5 pcs.
• Therapy of peptic ulcers of the duodenum, stomach during the period of exacerbation involves the use of "Galavit" in the amount of two suppositories once a day for the first two days, subsequently - every three days, one candle. The course of therapy includes the use of up to 25 rectal suppositories. The chronic period of the disease - one suppository once for 5 days, subsequently - 1 rectal suppository per day every three days. Duration of therapy - 20 pcs.
• For the treatment of infectious diseases of the intestine, accompanied by diarrhea, two supp. should be used once, and then one supp. twice a day until symptoms are relieved. The course can be continued using one supp. every three days. The course of therapy - 20 rectal suppositories.
• Chronic herpes diseases suggest using one supp for 5 days. per day, then every other day - 1 rectal suppository. Course - 15 rectal suppositories.
• The initial dosage for hepatitis of a viral nature is once two supp., Then twice a day, one supp. until the moment when intoxication and inflammation are stopped. Continue the course until 20 supp. are used, one every three days.
• Therapy for diseases associated with HPV involves the use of one supp. 5 days, then 1 rectal suppository every other day. Duration - 15 supp.
• For the treatment of sthenic conditions, somatoform and neurotic disorders, one piece is prescribed. within five days, subsequently - 1 rectal suppository every other day. Duration of reception - 15 pcs.
• In surgical diseases of a purulent nature, including burn lesions, chronic osteomyelitis, recurrent furunculosis, gangrenous appendicitis, purulent pleurisy, one supp is supposed to be taken. 5 days, in the next 10 days every other day - one supp.
• In the treatment of periodontal diseases and mucous membranes of the mouth, Galavit is recommended, one supp. within five days, then one supp. every three days. The course of therapy involves taking 15 pcs.
• Prevention and treatment of urogenital infections with bacterial and viral etymology involves the use of one supp twice a day, followed by 1 rectal suppository every other day. The course of treatment, depending on the severity of the disease, may include taking 10-15 rectal suppositories.
• Therapy and prevention of preoperative and postoperative surgical complications involves taking one supp for five days, then after the operation - one supp. every other day, then - one supp. every three days. The course includes the use of 20 slashes.
• Therapy of frequent diseases of the ENT organs with viral and bacterial etymology, for example, frequent acute respiratory viral infections, bronchitis, pneumonia, chronic tonsillitis, chronic otitis, chronic adenitis, involves the use of one supp. within five days, subsequently within ten days - one rectal suppository every other day.
• For the prevention of SARS, one supp should be used for five days.

"Galavit" with a dosage of 100 mg is intended for use in adolescents over 12 years of age, in adult patients:

• In order to improve efficiency, it is recommended that one supp is recommended every other day, then one supp every three days. Course - 15-20 rectal suppositories.
• With erysipelas, chronic furunculosis - 5 days, 1 rectal suppository, then every other day - one supp. Course - 20 rectal suppositories.
• Acute period of ulcers of the duodenum and stomach: during the first two days, 2 supp., And then every three days, 1 rectal suppository. Course - 15-25 rectal suppositories. Chronic period - the first five days, 1 supp., Then every three days, 1 rectal suppository. Course - 20 rectal suppositories.
• Intestinal infections with diarrheal syndrome in the acute period - once 2 pcs., Then twice a day, 1 supp. Until the symptoms disappear. The course of treatment can be continued using 1 rectal suppository every three days. The course is 20-25 candles.
• Viral hepatitis - once 2 suppositories, then twice a day - 1 supp. Until symptom relief. The course can be continued using 1 supp. every three days.
• HPV - the first 5 days, 1 rectal suppository, then every other day - 1 supp. Course - 20 rectal suppositories.
• Recurrent herpes diseases - the first five days, 1 suppository, then every other day - 1 supp. Course - 15 pcs.
• Salpingoophoritis, acute period of endometritis - during the first two days, once a day, 2 supp., then every three days - 1 rectal suppository. Chronic period - the first five days, 1 rectal suppository once, then every three days - 1 supp. Duration - 20 supp.
• Acute purulent diseases affecting the pelvic organs - 2 supp once, then 1 supp for 3 days, then 1 supp every other day. Course - 10 supp. Chronic period - the first five days, 1 supp, then every three days - 1 suppository.
• Rehabilitation after surgery for resection of uterine fibroids - 5 days, 1 rectal suppository, then every other day - 1 rectal suppository. Course - 15 supp.
• Prevention and treatment of surgical complications - the first five days once, 1 supp, after surgery - every other day, 1 supp. for 10 days, then every three days - 1 supp. Course - 20 supp.
• Asthenic conditions, somatoform and neurotic disorders, behavioral, mental, post-withdrawal disorders on the background of alcohol or drug addiction - 5 days, 1 rectal suppository, then every three days - 1 supp. Course - 15-20 pieces.
• Parodontosis, inflammation of the mucous membranes of the throat and mouth - 5 days, 1 rectal suppository, then every three days, 1 pc. Duration - 15 supp.
• Urogenital infections, including chlamydial urethritis and prostatitis, trichomonas urethritis - twice 1 supp. on the first day, then every other day, 1 rectal suppository. Course - up to 15 pcs.

This is confirmed by the instructions for use for Galavit candles.

Side effects

"Galavit" very rarely provokes the occurrence of side effects, in about 0.1% of cases. If these happen, they manifest themselves in the form of allergic reactions of the skin and mucous membranes - hives, rashes, redness, itching. If any side effect occurs while using Galavit, you should immediately contact your doctor.

Currently, there are no data on cases of overdose with Galavit suppositories. However, the recommended dosage should not be exceeded to avoid side effects.

Let us consider in more detail the instructions for candles "Galavit" in gynecology.

Gynecology

This medication is often used in complex therapy:

• exacerbation of genital herpes;
• urogenital diseases, in which non-specific, trichomonas, and also chlamydial etiology;
• purulent or inflammatory lesions in the pelvis;
• after gynecological surgical interventions in order to prevent complications and speedy recovery.

Interaction with other medicines

Parallel therapy with drugs that have an antibacterial effect can reduce the dosage of the latter.

During the course of therapy with Galavit, the use of alcoholic beverages is not prohibited, but you should not abuse them. So it is said in the instructions for use for candles "Galavit".

Other interactions of "Galavita" with other medicines are not currently registered.

Analogues

At the moment, "Galavit" has no analogues in terms of the active component. If there is a need, then it is possible to replace the Galavit suppositories with a different pharmacological form of the same drug. "Galavit" is also produced by the manufacturer in the form of solutions for injections and tablets. It is important to remember that it is necessary to replace Galavit candles with analogues only after consulting a doctor.

There are drugs that have a similar therapeutic effect. Among them: "Cycloferon", "Lavomax", "Amiksin", "Anaferon", "Immunoflazid", "Groprinosin", "Immunomax", "Echinacea-forte", "Immunal", "Immunofan", "Wobenzym", " Ribomunil, Imudon, Cordyceps, Timalin, Cellsept, IRS 19, Echinocor, Estifan, Ergoferon, Phlogenzym, Exalb, Timusamine, Tubosan ”, “Timogen”, “Taktevin”, “Splenin”, “Ruzam”, “Profetal”, “Neovastat”, “Myelopid”, “Imiquimod”, “Dezoksinat”, “Gepon”, “Bestim”, “Arpeflu”, "Tamerit".

Many people need to choose an analogue cheaper than Galavit candles. "Estifan" is today considered one of the most profitable substitutes for the drug we are describing. He has the same pharmaceutical group, but in the composition it contains a different active substance (estifan 200 mg).

How much and how is stored?

"Galavit" in the form of candles is recommended to be stored at a temperature of less than 12 degrees Celsius. Suppositories, subject to storage conditions, retain their therapeutic properties for 2 years. It is strictly forbidden to use the medication after its expiration date has expired.

The cost of "Galavita"

The average retail price of "Galavita" in the form of suppositories is at the level of 850-950 rubles per package. It contains 10 suppositories.

INSTRUCTIONS

for medical use

drug

Galavit â

Dosage form: Suppositories are rectal.

Compound: The active substance is sodium aminodihydrophthalazinedione (Galavit â) 100 mg; excipients - witepsol W-35 (fatty acid glycerides) - 575 mg, witepsol H-15 (fatty acid glycerides) - 575 mg.

Description: Suppositories from white to white with a yellowish tint, torpedo-shaped without visible inclusions on a longitudinal section.

Pharmacotherapeutic group:

Immunomodulatory and anti-inflammatory agent.

ATX code: L03, G02.

Pharmacological properties:

The mechanism of action of the drug is associated with the ability to influence the functional and metabolic activity of macrophages.

In inflammatory diseases, the drug reversibly inhibits for 6-8 hours the excessive synthesis of tumor necrosis factor, interleukin-1 and other pro-inflammatory cytokines, reactive oxygen species by hyperactivated macrophages, which determine the degree of inflammatory reactions, their cyclicity, as well as the severity of intoxication. Normalization of the functional state of macrophages leads to the restoration of the antigen presenting and regulatory functions of macrophages, and a decrease in the level of autoaggression. Stimulates the bactericidal activity of neutrophilic granulocytes, enhancing phagocytosis and increasing the body's nonspecific resistance to infectious diseases.

Pharmacokinetics: It is excreted from the body mainly through the kidneys. After rectal administration, the elimination half-life is 40-60 minutes. The main pharmacological effects are observed within 72 hours.

Indications for use:

As an immunomodulatory and anti-inflammatory agent in the complex therapy of immunodeficiency conditions in adults and adolescents over 12 years of age:

Infectious intestinal diseases accompanied by intoxication and / or diarrhea;

Peptic ulcer of the stomach and duodenum;

Viral hepatitis;

Chronic recurrent diseases caused by the herpes virus;

Diseases caused by the papilloma virus;

Infectious and inflammatory urogenital diseases (urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis, acute and chronic salpingo-oophoritis, endometritis);

Purulent-inflammatory diseases of the pelvic organs;

Postoperative rehabilitation of patients with uterine myoma;

Complications of the postoperative period in women of reproductive age;

Postoperative purulent-septic complications and their prevention (including in cancer patients);

Chronic recurrent furunculosis, erysipelas;

Asthenic conditions, neurotic and somatoform disorders, decreased physical performance (including in athletes); mental, behavioral and post-withdrawal disorders in alcohol and drug addiction;

Inflammatory diseases of the mucous membrane of the mouth and throat, periodontal disease;

Nonspecific prevention and treatment of influenza and acute respiratory infections.

Contraindications. Individual intolerance, pregnancy and lactation.

Dosage and administration: Rectally . The suppository is released from the contour packaging and then injected into the rectum. It is preliminary recommended to empty the intestines.

The dose and duration of the drug depends on the nature, severity and duration of the disease.

- In acute infectious intestinal diseases accompanied by diarrheal syndrome: the initial dose is 2 suppositories once, then 1 suppository 2 times a day until the symptoms of intoxication are relieved. Perhaps the subsequent continuation of the course of 1 suppository with an interval of 72 hours. Course 20-25 suppositories.

- With peptic ulcer of the stomach and 12 duodenal ulcer in the acute period: 2 days, 2 suppositories 1 time per day, then 1 suppository with an interval of 72 hours. Course 15-25 suppositories. In the chronic period: 5 days, 1 suppository 1 time per day, then one after 72 hours. Course 20 suppositories.

- For viral hepatitis: the initial dose is 2 suppositories once, then one at a time - 2 times a day until the symptoms of intoxication and inflammation stop. Subsequent continuation of the course of 1 suppository with an interval of 72 hours. Course 20-25 suppositories.

- In chronic recurrent diseases caused by the herpes virus: 1 suppository daily 5 suppositories, then one every other day - 15 suppositories.

- In diseases caused by the papillomavirus: 5 days, 1 suppository 1 time per day, then one suppository every other day. Course - 20 suppositories.

- In urogenital diseases - urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis: 1 day 1 suppository twice, then one every other day. Course 10-15 suppositories (depending on the severity of the pathological process).

- With salpingoophoritis, endometritis in the acute period: 2 days, 2 suppositories 1 time per day, then one at a time with an interval of 72 hours. In the chronic period:

- In acute and chronic purulent diseases of the pelvic organs- in the acute period: 1 day 2 suppositories once, 3 days one suppository daily, then one suppository every other day for 5 days. Course - 10 suppositories. In the chronic period: 5 days, 1 suppository 1 time per day, then one every 72 hours. Course - 20 suppositories.

For postoperative rehabilitation of patients with uterine myoma and complications of the postoperative period in women of reproductive age: 5 days, 1 suppository 1 time per day, then one suppository every other day. Course - 15 suppositories.

For the prevention and treatment of surgical complications in the pre- and postoperative period (including in cancer patients): appoint 1 suppository 1 time per day - 5 suppositories before surgery, 5 - after surgery, one every other day and 5 suppositories - with an interval 72 hours. In severe cases of the disease, the initial dose is 2 suppositories once or 2 times a day, one at a time. Course - 20 suppositories.

- In chronic recurrent furunculosis, erysipelas: 5 days, one suppository 1 time per day, then one suppository every other day. Course - 20 suppositories.

With asthenic conditions, neurotic and somatoform disorders, with mental, behavioral and post-abstinence disorders, in patients with alcohol and drug addiction: 5 days, one suppository daily, then one suppository every 72 hours. Course 15-20 suppositories. To improve physical performance: 1 suppository every other day - 5 suppositories, then one at a time - after 72 hours, the course is up to 20 suppositories.

- In inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases: the initial dose of 1 suppository daily - 5 suppositories, then one at a time - with an interval of 72 hours. Course 15 suppositories.

- For non-specific prevention and treatment of influenza and acute respiratory infections: one suppository 1 time per day. Course 5 days.

Side effects: In rare cases, allergic reactions are possible.

Interaction with other drugs: With simultaneous use, it is possible to reduce the course doses of antibiotics. Cases of incompatibility with other drugs have not been noted.

Release form: Suppositories rectal 100 mg. 5 pieces in a blister pack, 1 or 2 blisters with instructions for use in a cardboard box.

Best before date:

Do not use after the expiry date stated on the carton.

Storage conditions.

Store in a dry, dark place, out of the reach of children, at a temperature not exceeding 25°C.

Conditions for dispensing from pharmacies: