Instructions and indications for the use of anestezin in different dosage forms. Anestezin - Instructions for Use and Analogues Forms of release of drugs with anestezin in the table

Benzocaine ointment is a local drug used in the symptomatic treatment of diseases accompanied by pain. The drug has contraindications, so it should be used as prescribed by a doctor.

What is benzocaine?

(in Latin - benzocaine) - a substance that has an analgesic effect. It is a white crystalline substance with a bitter taste. Benzocaine is soluble in water, ethyl alcohol, ether, chloroform and oils.

Medicinal properties

The active substance has the following properties:

• reduces the permeability of the cell membrane, preventing the leakage of sodium ions;
• removes calcium ions from receptors located inside the cell membrane;
• inhibits the formation and movement of nerve impulses.

When used locally, the substance is practically not absorbed into the systemic circulation. The therapeutic effect occurs 1 minute after application and lasts 15-20 minutes.

What preparations include the substance?

The specified active substance contains the following medicines:

• Anestezin;
• Relief Advance;
• Dentispray.

Indications for use of Benzocaine ointment

Ointment is used for:

• severe inflammation of the middle part of the auditory canal;
• pain in the external auditory canal;
• skin diseases accompanied by pain and itching (urticaria, labial and genital herpes, shingles)
• painful teething in children;
• ulcerative and herpetic stomatitis;
• fungal infections of the mucous membranes of the oral cavity;
• performing diagnostic procedures (endoscopic examination of the esophagus, stomach, ear canal, urethra, vagina and rectum).

With hemorrhoids

Anestezol ointment, the active ingredient of which is benzocaine, is used when accompanied by:

• inflammation of the hemorrhoidal veins;
• infringement of nodes;
• irritation of the skin of the perianal region;
• the formation of anal fissures;
• inflammation of the mucous membranes of the rectum.

Application

Dental ointment is applied in a thin layer on the inflamed areas of the gums, rubbing with light massaging movements. The drug is used 3-4 times a day. Ointment for hemorrhoids based on benzocaine is applied in the morning and evening after performing hygiene procedures.

Contraindications to the use of Benzocaine ointment

The drug is contraindicated in case of individual intolerance to the active substance and auxiliary components.

Side effects of Benzocaine ointment

When using ointments based on benzocaine, the following undesirable consequences occur:

• contact dermatitis, manifested by itchy skin rashes;
• allergic reactions (erythematous rashes, burning and redness of the skin and mucous membranes, urticaria, swelling of soft tissues);
• persistent numbness of soft tissues at the site of application of the ointment;
• methemoglobinemia (when using the drug in children under 7 years of age).

Overdose

When applying the drug to large areas of the skin, there are:

• dizziness;
• breathing problems;
• impaired coordination of movements;
• cyanosis of the skin.

Substances that neutralize the effect of benzocaine have not been found. Treatment is symptomatic and supportive.

special instructions

In some cases, caution or refusal to use the ointment is required.

During pregnancy and lactation

It is not known how the drug can affect the development of the fetus, so it is rarely prescribed to pregnant women. Despite the fact that a small amount of the active substance is excreted in breast milk, it is not recommended to use the ointment during lactation.

Local anesthetics selectively block the process of excitation transmission in the afferent nerves and their endings, causing a loss of pain sensitivity at the site of their injection. There are different types of local anesthesia:

Superficial (terminal) anesthesia - occurs when anesthetics are applied to the surface of the skin, mucous membranes of the eyes, nose, etc .;

Conduction anesthesia - occurs when an anesthetic is injected into or near a nerve, as a result of which pain sensitivity is lost in the area innervated by this nerve; with spinal anesthesia, the anesthetic solution is injected directly into the subdural space (in the lumbar region), while the pain sensitivity of the lower half of the trunk and lower extremities is lost;

Infiltration anesthesia, in which the tissues of any part of the body are impregnated with an anesthetic in layers;

Intraosseous anesthesia is achieved by introducing an anesthetic into the cancellous bone with a tourniquet applied above the injection site of the anesthetic.

For each type of anesthesia choose a local anesthetic, taking into account its characteristics; to prolong the effect, a 0.1% solution of adrenaline is added (1 drop per 2-3 ml of a local anesthetic solution, but not more than 20 drops per entire dose of the solution administered to the patient).

COCAINE- In medical practice, cocaine hydrochloride is used for surface anesthesia. Cocaine hydrochloride is used in ophthalmic practice 1-3% solutions; for anesthesia of the mucous membranes of the larynx, nose, oral cavity - 2-5% solutions. Cocaine constricts blood vessels, dilates the pupil when instilled into the eye, and can increase intraocular pressure. When absorbed into the blood, cocaine excites the central nervous system, causes a state of euphoria, which is the cause of drug dependence (cocainism) and limits its use in medical practice. Side effects of cocaine hydrochloride: increases intraocular pressure, exacerbates glaucoma attacks. Release form cocaine hydrochloride: powder List A.

An example of a recipe for cocaine hydrochloride in Latin:

Rp.: Sol. Cocaini hydrochloridi 2% 5ml

Sol. Adrenalini hydrochloridi 0.1% gtts. II

M. D. S. For anesthesia of the cornea, conjunctiva, nasal mucosa (in the hands of a doctor).

Rp.: Cocaini hydrochloridi 0.1

Zinci sulfatis 0.05

Acid borici 0.2

Aq. destill. 10ml

M.D.S. Eye drops (in the hands of a doctor).

Rp.: Sol. Cocaini hydrochloridi 5% 10ml

Sol. Adrenalini hydrochloridi 0.1% gtts. V

M. D. S. For anesthesia of the nasopharynx (in the hands of a doctor)

NOVOCAINE(pharmacological analogues: procaine hydrochloride) is a local anesthetic. Novocaine is used for infiltration and conduction anesthesia, as well as to enhance the analgesic effect during general anesthesia, to relieve pain in stomach ulcers, duodenal ulcers, etc. Novocaine has low toxicity, causes a slight decrease in blood pressure. For infiltration anesthesia, a 0.25-0.5% solution of novocaine is used, for conductor anesthesia - 1-2% solutions, for spinal anesthesia - 5% solution. Side effects when using novocaine: dizziness, hypotension, sometimes allergic reactions. There is no cross-sensitization with lidocaine and trimecaine.

Contraindications to the use of novocaine: individual intolerance to the drug, it is not advisable to combine novocaine with the introduction of sulfanilamide preparations, since their effectiveness is sharply reduced.

Novocaine release form: powder; 20 ml ampoules of 0.25% and 0.5% solutions; 10 ml of 1% and 2% solutions; 5 ml of 0.5% and 2% solutions; 1 ml of 2% solution; vials of 200 ml and 400 ml of 0.25% and 0.5% solutions; candles of 0.1 g. List B.

An example of a novocaine recipe in Latin:

Rp.: Novocaini 0.5

Aq. destill. 200 ml

M.D.S. 1 tablespoon 3-5 times a day.

Rp.: Sol. Novocaini 2% 2ml

D.t. d. N. 6 in amp.

S. For conduction anesthesia.

Rp.: Sol. Novocaini 0.5% 20ml

D.t. d. N. 6 in amp.

S. For infiltration anesthesia.

Rp.: Novocaini 0.1

01. Cacao q. s.

M.f. supp.

D.t. d. No. 10

S. 1 suppository in the rectum.

LIDOCAINE(pharmacological analogues: xycaine, xylocaine) is a local anesthetic. Lidocaine is used for terminal, infiltration and conduction anesthesia. Lidocaine acts longer than novocaine. Lidocaine has an antiarrhythmic effect. Release form of lidocaine: 2 ml ampoules of 10% solution. List B.

An example of a lidocaine recipe in Latin:

Rp.: Sol. Lidocaini 10% 2 ml

D.t. d. N. 10 ampull.

S. For infiltration anesthesia (no more than 1000 ml); for conduction anesthesia (1% solution, 25-50 ml).

BUPIVACAINE HYDROCHLORIDE (pharmacological analogues: marcaine) - structurally close to lidocaine. Bupivacaine hydrochloride is highly active long-acting local anesthetic. Bupivacaine hydrochloride is used for infiltration anesthesia - 0.25% solution; for conduction anesthesia - 0.25-0.5%, in obstetric and gynecological practice - 0.25-0.5% solutions. When exceeding doses of bupivacaine hydrochloride, there may be convulsions, increased heart rate (up to cardiac arrest). Release form b upivacaine hydrochloride: ampoules, vials of 0.25% and 0.5% solutions.

TRIMECAINE HYDROCHLORIDE - used for conduction and infiltration anesthesia. Trimecaine hydrochloride acts stronger and longer than novocaine. Trimecaine hydrochloride also has an antiarrhythmic effect. Contraindications to the use of trimecaine hydrochloride: hypersensitivity to the drug. Release form trimecaine hydrochloride: powder; 2% and 5% solutions in 2 ml ampoules; 2% solution with 0.004% norepinephrine solution in 2 ml ampoules. List B.

An example of trimecaine hydrochloride in Latin:

Rp.: Sol. Trimecaini hydrochloridi 2% 2 ml

D.t. d. N. 10 ampull.

S. For infiltration anesthesia (0.25% - 800 ml; 0.5% - 400 ml; 1% - 100 ml); for conduction anesthesia (1% - 100 ml; 2% - 20 ml)

CIMESOL- combined preparation: contains trimekain, cyminal, methyl sulfoxide, propylene glycol and other components. Cimesol has a bactericidal, local anesthetic and hemostatic effect. The drug is applied to the wound surface from an aerosol can (within 1-2 s, 20-40 cm 2 foam, which corresponds to 2-4 g of the drug. Form release tsimezolya: aerosol cans containing 60 g of the drug.

DIOXYCOL- ointment, which includes trimekain, methyluracil dioxide, polyethylene oxides. Dioxicol is used as an antimicrobial, anti-inflammatory, local anesthetic and dehydrating agent for purulent-necrotic wound processes. Dioxicol is contraindicated in: elevatednoy sensitivity to the components of the drug, insufficient function of the adrenal cortex, pregnancy, during breastfeeding. Release form of dioxicol: ointment in jars of 100 g. List B.

DICAIN(pharmacological analogues: tetracaine hydrochloride) is a stronger anesthetic than novocaine. Dikain is toxic, and therefore its use requires great care (!). Dikain is used only for superficial anesthesia of the mucous membranes of the eyes, larynx, for epidural anesthesia (rarely). With the resorptive action of dicaine, poisoning (up to death) is possible. Dikain is contraindicated in children who are seriously ill. Release form of dicain: powder and eye films. List A.

An example of a dicaine recipe in Latin:

Rp.: Sol. Dicaini 0.5% 5ml

D.S. Eye drops (for superficial anesthesia).

ANESTESIN(pharmacological analogues: benzocaine) - a local anesthetic, insoluble in water, is used orally in powders, tablets, and for surface anesthesia - in the form of ointments, powders. Anestezin is a part of suppositories. Anestezin is contraindicated in case of hypersensitivity to the drug. Release form of anesthesin: powder; tablets of 0.3 g; Bellastezin tablets containing 0.3 g of anesthesin; candles "Anestezol" containing 0.1 g of anesthesin. List B.

An example of an anesthesin prescription in Latin:

Rep.: Tab. Anaesthesini 0.3 N. 20

D.S. 1 tablet 3 times a day (for cramps and pain in the stomach).

Rp.: Anaesthesini 0.5 Mentholi 0.1

Sol. Adrenalini hydrochloridi 0.1% 0.5 ml

Vaselli ad 10.0

M.f. ung.

D.S. Nasal ointment.

ULTRACAINE- local anesthetic. Ultracaine has a fast and strong anesthetic effect, well tolerated by patients. Ultracaine is used for superficial, infiltration and conduction anesthesia. Contraindications to the use of ultracaine: paroxysmal tachycardia, atrial fibrillation, glaucoma, allergy to drugs similar in structure. Release form of ultracaine: 2% ampoules - 10 ml each; 5% - 2 ml.

MENOVAZIN- a combined preparation containing anesthesin 1 g, novocaine 1 g, menthol 2.5 g and ethyl alcohol up to 100 ml. Menovazin has a local anesthetic and antipruritic effect. Menovazin is used for neuralgia, dermatosis, arthralgia and other diseases in the form of rubbing (2-3 times a day). Side effects when using menovazine: dizziness, weakness, lowering blood pressure. Contraindications to the use of menovazine: hypersensitivity to novocaine. List B.

PAVESTESIN- contains anesthesin 0.3 g and papaverine hydrochloride 0.05 g. Pavestezin is used for gastritis, intestinal spasms, etc. Pavestezin is prescribed orally 1 tablet 3 times a day. Release form of pavestezin: tablets. List B.

LINIMENT "SPEDIAN" - contains anesthesin 1 g, dikain 0.005 g, spermaceti 7 g, spermaceti oil up to 100 g. "Spedian" has a local anesthetic effect, and also promotes regeneration processes. "Spedian" is used for superficial burns, long-term non-healing wounds of various origins, for which 3-4 layers of gauze napkins soaked in liniment are applied to the affected surface. Dressings are changed after 3-5 days. The course of treatment is 1-3 weeks. Release form "Spediana": bottles of 100 ml.

An example of a Spediana recipe in Latin:

Rp.: Lin. Spedianum 100 ml

D. S. External (for wetting wipes, apply for superficial burns).

BUMECAINE HYDROCHLORIDE (pharmacological analogues: pyromecaine) is a local anesthetic used for surface anesthesia in ophthalmology (0.5-1%), otorhinolaryngology (1-2%). Bumecaine hydrochloride has an antiarrhythmic effect, and therefore is prescribed for ventricular extrasystoles, myocardial infarction, heart operations (50, 100, 150 mg or 5, 10, 15 ml of 1% pyromecaine solution in 5% glucose solution). Bumecaine hydrochloride is also used in the treatment of inflammatory diseases of the oral mucosa (5% ointment is applied to the painful area of ​​the oral mucosa). Side effects when using bumecaine hydrochloride: may occur with intravenous administration of the drug in the form of weakness, dizziness, fainting, a drop in blood pressure. Contraindications to the use of bumecaine hydrochloride: intravenous administration of the drug is contraindicated in violation of the functions of the liver and kidneys. Release form bumecaine hydrochloride: 5 ml ampoules of 1% pyromecaine solution in 5% glucose solution (for intravenous injection); ointment 5% in tubes of 30 g. List B.

An example of a recipe for bumecaine hydrochloride in Latin:

Rp.: Sol. Bumecaini hydrochloridi 0.5% 10 ml

D.S. 2 drops per eye (for superficial anesthesia).

Rp.: Ung. Pyromecaini 5% 30.0

D. S. Apply to the inflamed area in the mouth (0.1-0.5 g) for 10-15 minutes 3 times a day. The course of treatment is 7-10 days.

BENZOFUROCAINE- has a local anesthetic and central analgesic effect. As a local anesthetic, benzofurocaine is used in dentistry for infiltration anesthesia (2-5 ml of a 1% solution). As an analgesic, benzofurocaine is used for hepatic and renal colic, diseases and injuries of the central nervous system, peritonitis, etc. (in combination with tranquilizers, antispasmodics). Benzofurocaine is administered intramuscularly or intravenously. Use doses of benzofurocaine from 0.1 to 0.3 g (maximum dose 1.0 g). Side effects when using benzofurocaine: dizziness; weakness; with rapid intravenous administration of benzofurocaine, chills, nausea, vomiting are possible; when administered intramuscularly - a burning sensation at the injection site. Contraindications to the use of benzofurocaine: cerebrovascular accident, atrioventricular blockade, liver and kidney damage. Do not mix benzofurocaine solution with sodium thiopental solution and other solutions that have an alkaline reaction. Release form of benzofurocaine: ampoules of 2, 5 and 10 ml with a 1% solution of the drug. List B.

DIMEXID(pharmacological analogues: dimethyl sulfoxide) - has a pronounced local anesthetic, as well as anti-inflammatory and antimicrobial action. Dimexide is used for bruises, sprains, inflammatory edema, arthritis, eczema and other skin diseases. Dimexide is used in aqueous solutions from 10 to 70% with compresses, for soaking tampons and dressings; 5% solutions - for storage of transplants. Side effects when using dimexide: slight burning, itching, small skin rashes. Contraindications to the use of dimexide: pregnancy, severe diseases of the liver, kidneys, cardiovascular system. Dimexide release form: 100 ml bottles.

Anestezin is a local anesthetic intended for superficial anesthesia. Provides blocking of the conduction of nerve impulses, preventing the appearance of pain excitation at the endings of sensory nerves.

After applying the anesthetic to the mucous membranes of the oral cavity, its effect is manifested after 1 minute.

Release form and composition

The active substance of the drug is benzocaine.

1 g of the active substance is soluble in chloroform (2 ml), ether (4 ml), ethanol (5 ml), as well as in fatty oils (30-50 ml) and diluted hydrochloric acid. Worst diluted in water (2500 ml).

Anestezin is available in the form:

• White crystalline powder in the form of a powder of local action;
• Tablets 0.1 g, 50 pieces per pack;
• Tablets 0.3 g, 6-10 pieces per pack;
• Ointments for external use 5% and 10%;
• Solutions for external use;
• Suppositories (candles) for rectal administration of 0.05 g and 0.1 g.

Indications for use

The use of Anestezin inside is indicated for esophagitis, gastralgia, as well as peptic ulcer of the stomach and duodenum.

Externally, the drug is used for:

• Pain in the gums;
• toothaches;
• Acute inflammation of the middle ear;
• Pain in the area of ​​​​the external auditory canal;
• myositis,
• Urticaria;
• Pathologies of the skin, accompanied by itching;
• Diseases of the superficial veins
• prolapse of hemorrhoids;
• Perianal fissures.

Anestezin is widely used during various diagnostic procedures on the mucous membranes in otoscopy, gastroscopy, ureteroscopy, rectoscopy and gynecological procedures.

In dentistry, it is used for surface anesthesia.

Contraindications

The use of Anestezin is contraindicated in case of hypersensitivity to benzocaine.

Method of application and dosage

Anestezin, according to the instructions, is taken depending on the indications as follows:

• Inside - with pain in the stomach and high sensitivity of the esophagus as an anesthetic, 0.3 g about 3-4 times a day. The maximum single dose of the drug for adults should not exceed 0.5 g, and the daily dose - 1.5 g. Permissible doses for children from 6 to 12 years old are 0.12-0.25 g, from 2 to 5 years old - 0.05 -0.1 g, up to 1 year - 0.02-0.04 g;

• Outwardly - on the affected area in the form of a 5% ointment, powder or solution for external use for urticaria and skin diseases, as well as for anesthesia of ulcerative and wound surfaces. In case of inflammation of the hearing aid, 4-5 drops are injected into the external auditory canal, followed by the introduction of a cotton swab. The application should be repeated if necessary every few hours;
• Locally - in suppositories of 0.05-0.1 g, as well as for lubrication of the mucous membranes in the form of a 5% or 20% oil solution.

Side effects

The instructions for Anestezin indicate the following side effects:

• tingling;
• Burning;
• Erythema;
• Hives;
• Edema;
• contact dermatitis;

At the site of application, a permanent decrease in sensitivity may develop.

In overdose, a number of symptoms are observed, such as shortness of breath, cyanosis, dizziness and methemoglobinemia, especially in infants and young children.

Treatment is symptomatic with intravenous methylene blue.

special instructions

There is not enough data on the effects of benzocaine on reproductive ability and the embryo, so the use of Anestezin during pregnancy is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

Caution is required during lactation, as it is not known whether benzocaine passes into breast milk.

The action of the anesthetic is enhanced by non-narcotic analgesics and cholinesterase inhibitors.

The antibacterial activity of sulfonamides is reduced when combined with Anestezin.

At the time of treatment should refrain from taking alcoholic beverages.

Analogues

Benzocaine is the active ingredient in drugs such as Dentisprey and Relief Advance.

The analogues of Anestezin according to the mechanism of action are:

• Amprovizol (aerosol);
• Helikain (gel);
• Dinexan (gel);
• Lidocaine (gel, spray);
• Luan (gel);
• Menovazin (alcoholic solution for external use);
• Pyromecaine (ointment).

Terms and conditions of storage

Store in a dry place protected from light. Keep away from children.

Shelf life - 5 years.

Benzocaine, Anestalgin, Anestetsin, Anestin, Egoform, Norkain, Paratezin, Retokain, Toponalgin.

Recipe:

Rp: Anaesthesia 0.3
D.t. d. No. 10 in tab.
S. 1 tablet for pain in the stomach (no more than 4 tablets per day)

Pharmachologic effect:

Anestezin is used to reduce surface sensitivity. The active substance of the drug is benzocaine.

The active substance of Anestezin, when taken, helps to reduce the permeability of cell membranes to sodium, and, in addition, removes calcium from receptors located inside the membranes. As a result, the conduction of nerve impulses is blocked. Thus, the drug does not allow the appearance of pain sensations in the endings of sensory nerves, their spread further along the fibers.

This tool belongs to the fast-acting drugs. After its application to the oral mucosa, the analgesic effect occurs within one minute.

Mode of application:

Inside, 0.3 g of Anestezin 3-4 times a day. Higher doses: single - 0.5 g, daily - 1.5 g; for children - up to 1 year old - 0.02-0.04 g, 2-5 years old - 0.05-0.1 g, 6-12 years old - 0.12-0.25 g.

Outwardly, a gel, 5% ointment or solution of Anestezin for external use is applied to the affected area.

In case of inflammation of the hearing aid - 4-5 caps into the external auditory canal, followed by tamponade with cotton cloth. If necessary, the application of Anestezin is repeated every 1-2 hours.

Release form:

Anestezin is produced in the form:
- tablets of 0.3 g;
- powder;
- Anestezin ointments;
- candles with Anestezin;
- oil solutions.

Indications:

For anesthesia of mucous membranes, with spasms and pains in the stomach, increased sensitivity of the esophagus, for anesthesia of the wound and ulcerative surface of the skin; with urticaria and skin diseases accompanied by itching.
Sometimes with primary vomiting, vomiting of pregnant women.

Contraindications:

According to instructions,
Anestezin is contraindicated in patients who have an increased individual sensitivity to benzocaine. In addition, this drug is prescribed with caution and under medical supervision to children under the age of two years and lactating women.

Side effects:

The use of Anestezin causes side effects only in some cases, most often they manifest themselves in the form of allergic reactions and contact dermatitis.

anesthesin

The international name of Anestezin is Benzocaine. This drug is a local anesthetic used to reduce surface sensitivity.

Preventing the occurrence of pain in the nerve endings, Anestezin blocks the conduction of pain impulses along the nerve fibers. This drug does not cause a reaction after being absorbed into the blood or distributed throughout the body.

After Anestezin is applied to the oral mucosa, its action develops within one minute. Influencing the mucous membrane of the gastrointestinal tract, this drug is able to reduce appetite to some extent (anorexigenic effect).

Indications for use

According to the instructions, Anestezin should be used orally for the following diseases:

• peptic ulcer of the stomach and duodenum;
• esophagitis;
• gastralgia.

Anestezin for external use is used in the following cases:

• gum pain, toothache;
• pain in the external auditory canal, otitis media;
• myositis;
• urticaria, skin diseases that are accompanied by itching;
• perianal fissures, superficial vein diseases.

Anestezin is widely used when performing various diagnostic procedures on the mucous membranes (rectoscopy, otoscopy, gastroscopy, ureteroscopy, gynecological procedures).

Release form and instructions for use Anestezin

Anestezin is hardly soluble in water, in connection with this, this drug is not administered as injections. Anestezin ointment and powder are widely used to relieve itching in urticaria, various skin diseases, as well as to anesthetize ulcerative and wound surfaces. Apply 5-10% Anestezin ointment, powders or finished drugs, such as Amprovizol, Menovazin and others.

There are suppositories with anestezin, the use of which is advisable for diseases of the rectum (hemorrhoids, itching, cracks). The content of the active substance in suppositories with anesthesin is 0.05-0.1 g. For anesthesia of the mucous membranes, as a rule, 5-20% oil solutions are used. Anestezin in tablets, powders, mixtures helps to reduce the sensitivity of the mucous membranes with increased sensitivity of the esophagus, pain and cramps in the stomach, etc.

Inside Anestezin applied 300 mg three or four times a day. In extreme cases, it is possible to use 500 mg preparations as a single dose, while the daily dose should not exceed 1500 mg. In the instructions for Anestezin, when prescribing this drug, the following single doses are recommended for children: children under 12 months - 20-40 mg, from 2 to 5 years - 50-100 mg, and children in the age group from 6 to 12 years are usually prescribed 120–250 mg.

Pain during inflammation of the hearing aid is removed with the help of 4-5 drops of Anestezin solution, which are injected into the external auditory canal. If necessary, this procedure is repeated every 1-2 hours.

Side effects

The use of Anestezin can cause contact dermatitis, allergic reactions, as well as a persistent decrease in sensitivity at the site of application of the drug.

Contraindications

The instructions for Anestezin indicate only one contraindication - hypersensitivity. Caution is necessary when prescribing this drug to children under 2 years of age and to lactating women.

Additional Information

Anestezin should be stored in a dry and cool place. The shelf life depends on the form of release of the drug and is indicated on the package - from 2 to 10 years.

Sincerely,