Nise indications. What are Nise painkillers taken from? Overdose with Nise

Medicines, which are called anti-inflammatory non-steroidal drugs, are in great demand in childhood, because they effectively help reduce the temperature during fever and get rid of pain caused by various reasons.

One of them is "Nise", the action of which is due to the active substance called "nimesulide".

Release form

"Nise" is produced in several dosage forms, including the following.

Suspension. One bottle of this medicine contains 60 mg of a sweet-tasting yellow liquid that smells good. Shake it well before each use.
Tablets that dissolve in water(dispersible). They are light yellow in color and shaped like a D, and have an NK mark on one side. One package contains 10 or 20 tablets, but there are packs with 10 blisters.
Pills to be swallowed. They are characterized by convex on both sides, round shape and white-yellowish color. Such tablets are sold from 10 to 100 pieces in one pack.
Gel. It is a transparent yellow mass placed in aluminum tubes in the amount of 20 or 50 grams.

Compound

As already mentioned, the action of all forms of "Nise" is due to nimesulide. According to the instructions, the amount of such a substance in 5 ml of liquid medicine and in one dispersible tablet is 50 mg, and in one regular tablet - 100 mg. One gram of gel contains 10 mg of nimesulide, that is, such a medicine is 1%. Excipients of different forms are different, therefore, in case of intolerance, they should be specified on the box of the selected drug.

Operating principle

"Nise" is able to affect pain, fever or inflammation, as it inhibits the formation of substances called "prostaglandins". It is they that cause an active inflammatory process, a feeling of pain and an increase in body temperature. Their synthesis stops due to the influence of nimesulide on cyclooxygenase 2, because this enzyme is involved in their formation.

As a result of the action of "Nise", the body temperature decreases, pain decreases, and the inflammatory reaction becomes less pronounced.

The medicine taken orally is quite actively absorbed and carried by the blood to different tissues. Metabolism of the drug takes place in the liver cells, and excretion from the body occurs with bile and through the kidneys.

The gel is applied only topically and acts exclusively on the area that has been treated. Thanks to its use, pain is weakened, and if the remedy is applied to the joints, it helps to reduce swelling and eliminate stiffness.

When is it used?

"Nise" is often prescribed for pain, for example, if the baby has an earache with otitis media. Such a medicine is in demand for headaches, in dental practice, after an injury or surgery. Since "Nise" is very effective in dealing with inflammation, this drug is often used in the treatment of bursitis, arthritis, tendonitis and similar problems.

The antipyretic effect of the drug makes it possible to prescribe it for fever caused by a sore throat or another disease.

The reason for using the gel is a bruise, sprain, dislocation, muscle pain, arthritis and other pathologies in which you need to locally anesthetize and reduce the inflammatory process.

Is it allowed for children?

All types of "Nise" are not used in the treatment of children in the first two years of life.

If you need to bring down the temperature or relieve pain in such small patients, they resort to analogues allowed for infants and children 1-2 years old.

"Nise" in suspension is allowed from the age of two, in the form of dissolving tablets - from 3 years.

The drug in the form of a gel can treat the skin of children from the age of 7, and tablets with a dosage of 100 ml are prescribed no earlier than 12 years.

Contraindications

The use of "Nise" is prohibited if a small patient has:

hypersensitivity to nimesulide;
intestinal inflammation;
active liver disease;
bronchial asthma;
problems with blood clotting;
intolerance to any auxiliary components;
ulcerative lesions of the stomach;
bleeding in the gastrointestinal tract;
disturbances in the work of the heart;
severe kidney damage;
elevated levels of potassium in the blood.

Nise women are not prescribed during childbearing and breastfeeding.

The gel is not used on infected or damaged areas of the skin, as well as on the mucous membrane and during breastfeeding.

Side effects

Taking "Nise" inside can cause a negative reaction of the digestive tract, for example, nausea, loose stools, or pain in the stomach. Sometimes a medicine causes headaches, allergies, sweating, swelling, drowsiness, or other side effects.

How to apply?

Suspension and soluble tablets are given before meals, but at the risk of negative effects on the gastrointestinal tract, they should be taken with or after meals. One tablet is dissolved in a teaspoon of water. The dosage of such forms is calculated by weight and divided into 2-3 doses. "Nise" in tablets with a dosage of 100 mg is also taken after meals. Such a medicine is given to a teenager twice a day, one tablet, but not more than two tablets per day.

The gel is applied to the washed and dried area of the skin. It is applied in a thin layer, evenly distributing the medicine over the surface where there is pain. It is not necessary to rub the medication, and the frequency of treatment with ointment is 3-4 times a day.

The duration of the use of the selected form of "Nise" should be checked with the doctor, since in some cases it is enough to take the drug 1-2 times, and sometimes treatment is required for 5-7 days or longer. To reduce the risk of negative consequences, such a remedy is prescribed at the lowest possible rate.

Overdose

If a child accidentally drinks a large dose of the drug, it will lead to drowsiness, nausea, lethargy, or vomiting. In severe overdose, breathing problems, stomach bleeding, kidney failure, and other health hazards may occur, in which case medical attention should be sought. Since there is no antidote to the active substance "Nise", symptomatic treatment is used in case of an overdose.

drug interaction

If "Nise" is administered orally, then it should not be combined with many other drugs indicated in the annotation for tablet forms and suspensions. Among them, anticoagulants, diuretics, and other anti-inflammatory drugs are noted.

If the child is already taking some kind of medicine, then it is worth talking about compatibility with the attending physician.

Purchase and storage

All oral forms of Nise are available by prescription, but the gel is an over-the-counter remedy. The price of the drug depends on its type and size of the package.

All forms of medication should be stored at home at a temperature not exceeding +25 degrees. The shelf life of the gel is 2 years, the remaining options for "Nise" are 3 years.

A rich selection of pharmacological preparations can confuse a person. Without knowing the full composition, as well as its active substance, any person can make the wrong choice of the drug and harm his body. Of course, each drug is prescribed by a doctor, but then you need to know the exact indications, contraindications and possible side effects.

And those cases when the patient himself chooses a treatment for himself and applies it on himself, may end in failure. It turns out, in any case, it is better to get acquainted with the instructions, and be sure of the correct prescription of the medication.

Nise is considered one of the effective medicines. The people also call him Nice. It is popular for being able to quickly relieve fever, relieve pain, and Nise tablets are also considered an effective remedy for headaches. Below, each reader will be able to study in detail the description of the annotation of Nice tablets.

The indication for the use of the drug includes the ability to relieve headaches. Therefore, this drug is often used by people when they suffer from migraines.

Nice tablets can be prescribed by dentists to their patients, for example, when they are worried about severe toothache.

In gynecology, they are prescribed in order to relieve pain during menstruation. Usually, Nise is an ally of women with algomenorrhea.

Nise tablets have the following indications:

Rheumatoid arthritis is a systemic connective tissue disease that predominantly affects small joints.
Articular syndrome during an exacerbation of gout, rheumatism.
Psoriatic arthritis is a form of joint inflammation in psoriasis patients.
Betcher's diseases are chronic systemic diseases of the joints, which are more often localized in the sacroiliac joints, in the region of the spine and soft tissues.
Indicated for use in sciatica.
As well as sciatica in the lumbosacral region.
May be prescribed for lumbago (acute pain in the lower back).
Diseases associated with osteoarthritis.
Arthritis is caused by a variety of etiologies.
It is prescribed for pain in the joints of a volatile nature, in which there are no pronounced symptoms of joint damage.
Myalgia, which are caused by rheumatic and non-rheumatic genesis.
Tablets are indicated when ligaments, tendons and bursitis (a mucous bag in the joint area) become inflamed.
Inflammatory process after an injury associated with soft tissue and the musculoskeletal system (rupture, bruising of ligaments).
Severe pain of various origins (during periods after surgical interventions, during various injuries, etc.).
Fever is caused by a variety of inflammatory processes in the body.

It is important to remember that using Nice tablets, patients do not get rid of the disease development factor. The drug is able to remove the symptoms: relieve general and headache, lower body temperature and eliminate the inflammatory process in the body, but only for a while.

The pathology itself is treated in combination with other medical products. Before use, read the instructions for use again. The medicine in the form of the drug Nise is not a panacea for all diseases.

The composition of the drug and the form of release

The chemical composition of Nise tablets includes the main active ingredient - it is nimesulide. It is able to stop pain and various inflammatory processes. It has a high absorption and if you drink a Nise tablet with severe headaches, the maximum concentration in the blood will reach in 1 to 2 hours.

The drug is excreted from the body through the kidneys and bile after 2 to 5 hours.

In addition to it, the drug consists of additional elements. There are several of them:

Calcium fosvat;
Microcrystalline cellulose;
Corn starch;
magnesium stearate;
sodium glycolate;
Silicon dioxide colloidal;
Talc;
Aspartame;
Flavoring.

The pharmacological composition of the tablets differs from other types of Nice release (gel and suspension), but the active element remains unchanged - it is nimesulide.

This tool is available in tablets with different amounts of active ingredient:

Tablets Nise, which has 100 mg of the main element nimesulide and there are 10 of them in a blister pack;
The second type is dispersible tablets. They contain 50 mg of the active element nimesulide. 10 pieces in a blister.

Pharmacological action of tablets

Nise tablets are a non-steroidal anti-inflammatory drug.

Tablets have antipyretic, analgesic and anticoagulant effects.

Also, the drug slows down the reactions of fat oxidation and prevents the formation of hormone-like substances during inflammatory reactions.

The composition of Nice has a great effect on the body in the following way:

Analgesic;
Relieves body heat, stops fever;
Soothes pain;
And antiplatelet property;
Able to suppress prostaglandins in the very center of the inflammatory process;
Helps slow down lipid oxidation;
Does not affect phagocytosis and hemostasis;
Well absorbed into the body;
Already a maximum of 2 hours after taking the drug nimesulide and other components will work at maximum;
Within three hours, half is excreted from the body;
The composition of the tablet is not accumulated by the body;

Contraindications for the use of the drug

People with heart pathologies, diabetes mellitus of the 2nd degree and high blood pressure should immediately stop taking Nise tablets if they were not prescribed by a doctor. There are also contraindications for hypersensitivity to the components that make up the Nise tablets.

We have already found out the use of tablets.

But, like other medicines, Nice has a number of contraindications:

Nice tablets are contraindicated in children under 12 years of age; in other forms of release, children under 2 years of age;
Pregnant women;
Contraindicated in women while breastfeeding. In cases where the doctor insists on the use of tablets, you should not feed the baby until this medication is discontinued.
Do not take during periods of exacerbation of erosion, gastrointestinal ulcers.
The composition of the drug is contraindicated during bleeding of the digestive system.
Should not be taken by persons with severe renal insufficiency;
With the aspirin triad syndrome, this is aspirin intolerance with polyps and bronchial asthma;
Allergy to any component of the product.

Also, do not abuse this method of treatment with nimesulide for people who have such problems:

Heart failure;
Take with caution in patients with type 2 diabetes mellitus (insulin dependent);
Persistent high blood pressure;
For vision problems;
And impaired renal function.

Instructions for use and dosage

The first thing you should pay attention to is that any medication must be prescribed by a doctor. The second, includes its correct use and the use of Nice in the indicated dosage. All this will reduce the risk of side effects or other undesirable consequences.

The instructions indicate that it is necessary with nimesulide after a meal, because before it the components of the drug can provoke irritation in the stomach. The tablet should be taken whole, without chewing or crushing. After that, it is recommended to drink it with a glass of water.

You can drink to children over 12 years of age in the same dosage as adults. But, if their mass is less than 40 kg, then it is worth using the calculation method:

3.5 mg of nimesulide and other components per 1 kg of body weight of a child. Drink 2-3 times a day.

For people over 65 years of age, the usual dosage is maintained.

When the patient has renal insufficiency, it is determined using the Rehberg test, not less than 30 ml / min, then the dosage is not reduced. When the indicator is less than the specified, then the tablets are strictly forbidden to be taken.

Dispersible tablets can be taken by children from 3-12 years old. Dissolve one tablet in a teaspoon and take it orally. Children from 2 to 3 years old are prescribed Nise suspensions.

To remove pain and relieve headache from fever, the drug is prescribed in tablets 2 times a day. It is recommended to maintain the same period of time between doses (every 12 hours). Some diseases require an increase in the dose, but you should not drink more
e 400 mg in 24 hours. In order not to provoke an overdose and cause side effects.

Tablets are prescribed to take no more than 10 days.

Side effects of Nise tablets

Like all medicines, Nise can cause some side effects. Among them note:

From the gastrointestinal tract: heartburn, vomiting, pain in the stomach, erosive and ulcerative disease of the gastrointestinal tract, diarrhea, toxic hepatitis.
Central nervous system: severe headaches, dizziness.
Circulatory system: diseases of thrombocytopenia, leukopenia, anemia, agrunolocytosis may appear.
Side effects can appear in the form of allergic reactions: bronchospasm, skin rashes, anaphylactic shock.
There may be fluid retention in the body.
The bleeding time is somewhat lengthened.
The patient may find blood in her urine.
Drowsiness.
Pain in the pelvis.
Petechiae may appear or they are also called ecchymosis - these are tiny bruises or pinpoint hemorrhages on the skin of a person.
Melena is a black liquid stool with an unpleasant odor.
Purpura. Purpura is understood as small-spotted capillary hemorrhages in the skin, under the skin or in the mucous membranes.
Oliguria is a decrease in urine output compared to the norm.
High activity of "liver" transaminases.

The well-known actions that the patient should do when he notices one of the side effects in himself:

Stop taking the drug;
Seek medical advice;
Based on the result of the consultation, the doctor will either prescribe a different regimen or prescribe another drug.

Overdose

In case of an overdose of the Nise drug, the patient may experience the following symptoms:

Renal function disorders;
Nimesulide, as well as other components of Nice, can cause kidney failure.
The gastrointestinal tract also reacts sharply to an overdose of the drug: irritation of the mucous membrane of the intestinal tract.
Overdose of pills can even cause convulsions.
Blood pressure may rise.
In some cases, rapid intermittent breathing appears.

In fact, these are enhanced side reactions.

In such cases, you should immediately stop using this medication.

Then engage in timely treatment for overdose:

The first thing to do is to rinse the stomach from the remnants of Nice's components in the body.
As a reduction of toxins in the body, you need to take coal.
Then carry out symptomatic therapy.

In this situation, there is no specific antidote. Be sure to tell your doctor, he will give more accurate information on what to do in this case.

Interaction with other drugs

Some drugs can compete with the active ingredient nimesulide and other components of the drug. Accordingly, cause drug interactions.

These dosage forms include protein:

Dioxygon;
Phenytoin;
Lithium means;
Diuretics;
antihypertensive agents;
Other NSAIDs (non-steroidal anti-inflammatory drugs);
Anticoagulant;
Cyclosporine;
Methotrexate;
Oral hypoglycemic drugs.

NSAIDs. Selective COX-2 inhibitor

Active substance

Release form, composition and packaging

Pills white with a yellowish tint, round, biconvex, with a smooth surface.

Excipients: calcium hydrogen phosphate - 75 mg, microcrystalline cellulose (type 114) - 40 mg, corn starch - 54 mg, sodium carboxymethyl starch - 35 mg, magnesium stearate - 3 mg, colloidal silicon dioxide - 2 mg, talc - 1 mg.

10 pieces. - blisters (1) - packs of cardboard.
10 pieces. - blisters (2) - packs of cardboard.
10 pieces. - blisters (10) - packs of cardboard.

pharmachologic effect

NSAIDs from the sulfonanilide class. It is a selective competitive inhibitor of COX-2, inhibits the synthesis of prostaglandins in the focus of inflammation. The inhibitory effect on COX-1 is less pronounced (rarely causes side effects associated with inhibition of prostaglandin synthesis in healthy tissues). It has anti-inflammatory, analgesic and pronounced antipyretic effect.

Pharmacokinetics

Suction

After oral administration, nimesulide is well absorbed from the gastrointestinal tract. Eating reduces the rate of absorption without affecting its degree. C max nimesulide is 3.5-6.5 mg / l.

Distribution

Nimesulide may increase the possibility of adverse reactions while taking methotrexate.

The concentration of lithium in plasma increases with the simultaneous administration of lithium preparations and nimesulide.

Due to the high degree of binding of nimesulide to plasma proteins, patients who are simultaneously treated with hydantoin and sulfonamides should be under the supervision of a physician, undergoing examination at short intervals.

Nimesulide may increase the effect on the kidneys.

When used simultaneously with GCS, serotonin reuptake inhibitors increases the risk of gastrointestinal bleeding.

special instructions

Since nimesulide is partially excreted by the kidneys, its dose for patients with impaired renal function should be reduced, depending on the CC value.

Given reports of visual impairment in patients taking other NSAIDs, treatment should be stopped immediately if any visual impairment occurs and the patient should be examined by an ophthalmologist.

The drug can cause fluid retention in the tissues, so patients with high blood pressure and with cardiac disorders Nise should be used with extreme caution.

Regular medical supervision is required if the patient, along with nimesulide, is taking medications that are characterized by an effect on the gastrointestinal tract.

If there are signs of liver damage (skin itching, yellowness of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of liver transaminases), you should stop taking the drug and consult your doctor.

Do not use the drug simultaneously with other NSAIDs.

The drug can change the properties of platelets, but does not replace the preventive action of acetylsalicylic acid in cardiovascular diseases.

After 2 weeks of using the drug, it is necessary to control the biochemical parameters of liver function.

Pediatric use

The drug is contraindicated in children under the age of 12 years.

Influence on the ability to drive vehicles and control mechanisms

The drug can cause drowsiness, dizziness and blurred vision, so you need to be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Terms and conditions of storage

The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25°C. Shelf life - 3 years.

Nimesulide is an active substance that has anti-inflammatory, analgesic and antipyretic properties. Nimesulide selectively inhibits COX-2 and inhibits the synthesis of prostaglandins in the focus of inflammation. Nimesulide inhibits the release of the enzyme myeloperoxidase, and also inhibits the formation of free oxygen radicals, without affecting the processes of phagocytosis and chemotaxis, inhibits the formation of tumor necrosis factor and other inflammatory mediators.
After oral administration, nimesulide is rapidly absorbed from the gastrointestinal tract. The maximum plasma concentration is determined after 2-3 hours. The binding of nimesulide to plasma proteins reaches 97.5%.
The drug is metabolized in the liver, the main metabolic product is hydroxynimesulide, a pharmacologically active substance. About 65% of the dose of nimesulide taken is excreted in the urine, the remaining 35% is excreted in the feces.

Indications for the use of the drug Nise

sharp pain; symptomatic treatment of osteoarthritis with pain syndrome; primary dysmenorrhea.

The use of the drug Nise

In order to prevent the occurrence and to reduce the severity of adverse reactions, the drug should be taken for the shortest possible time and at the lowest effective dose. It is necessary to prescribe the drug only after a thorough assessment of the risk/benefit ratio.
The drug is taken orally after a meal and washed down with a sufficient amount of liquid.
For adults and children over 12 years old - 1 tablet (100 mg) 2 times a day - in the morning and in the evening.
The suspension is prescribed for adults and children over 12 years of age at a dose of 100 mg (10 ml) 2 times a day after meals. The maximum daily dose is 200 mg.
The maximum duration of treatment is 15 days.
For elderly patients, the indicated dosing regimen does not require correction.

Contraindications to the use of the drug Nise

peptic ulcer of the stomach and duodenum in the acute stage; severe liver dysfunction (liver failure) and hepatotoxic reactions to taking the drug in history, simultaneous use with potentially hepatotoxic drugs; severe renal dysfunction (creatinine clearance less than 30 ml / min), severe blood clotting disorders; severe heart failure; hypersensitivity to nimesulide or any other component of the drug, as well as hypersensitivity reactions to other NSAIDs in history; the period of pregnancy (III trimester) and lactation; children under the age of 12; alcoholism, drug addiction; elevated body temperature, flu-like condition, suspicion of acute surgical pathology.

Side effects of Nise

When using the drug, the following side effects may occur, mainly during the 1st week from the start of treatment:
from the skin side: most often - rash, itching, increased sweating, erythema, dermatitis; in some cases - angioedema, swelling of the face, erythema multiforme, urticaria, Stevens-Johnson syndrome and toxic epidermal necrolysis;
from the gastrointestinal tract: nausea, gastritis, abdominal pain, diarrhea, constipation, flatulence; in some cases - stomatitis, melena, peptic ulcer of the stomach or duodenum, perforation of the ulcer or gastrointestinal bleeding;
from the liver: jaundice, cholestasis, increased levels of hepatic transaminases, sometimes there may be cases of acute hepatitis, even with a fatal outcome;
from the side of the central nervous system: drowsiness, headache, dizziness, encephalopathy (Reye's syndrome);
mental disorders: anxiety, nervousness, nightmares;
from the side of the kidneys: edema, dysuria, hematuria, urinary retention, isolated cases of oliguria, interstitial nephritis, and renal failure;
from the blood system: anemia, eosinophilia, isolated cases of pancytopenia, purpura and thrombocytopenia;
from the immune system: hypersensitivity reactions, anaphylaxis;
from the respiratory organs: dyspnea, in some cases - BA, bronchospasm, especially in patients with hypersensitivity to acetylsalicylic acid and other NSAIDs;
from the cardiovascular system: tachycardia, hypertension (hypertension), rarely - bleeding, hot flashes, fluctuations in blood pressure. Also, while taking the drug, visual impairment, asthenia, hypothermia, hyperkalemia are possible.

Special instructions for the use of the drug Nise

To reduce the risk of side effects, it is necessary to use the minimum effective dose with the shortest duration of treatment. If the patient's condition does not improve, treatment should be discontinued.
In the event of an increase in liver enzymes or signs of liver damage (eg anorexia, nausea, vomiting, abdominal pain, fatigue, dark urine), the drug should be discontinued. Such patients are prohibited from prescribing nimesulide in the future.
During treatment with nimesulide, it is recommended to avoid the simultaneous use of hepatotoxic drugs, analgesics, other NSAIDs, and also to refrain from drinking alcohol.
Gastrointestinal bleeding or ulcer/perforation may develop at any time during the use of the drug, with or without warning symptoms, with or without a history of gastrointestinal complications. If gastrointestinal bleeding or ulcers occur, the drug should be discontinued.
With caution, nimesulide should be prescribed to patients with gastrointestinal disorders, ulcerative colitis or Crohn's disease in history.
With caution, the drug should be prescribed to patients with renal or heart failure, as its use may lead to deterioration of renal function. In case of decreased renal function, the drug must be discontinued.
Elderly patients most often develop side effects due to taking the drug, including gastrointestinal bleeding, perforation, impaired function of the heart, kidneys and liver. Therefore, regular clinical monitoring of the patient's condition is recommended.
Since nimesulide can increase platelet function in patients with hemorrhagic diathesis, it should be used with caution, under constant monitoring.
The use of NSAIDs may mask an increase in body temperature associated with an underlying bacterial infection. In the event of an increase in body temperature or the appearance of flu-like symptoms, the drug should be discontinued.
Children
The drug is contraindicated in children under the age of 12 years. Dosing for children over 12 years of age is the same as for adults.
Use during pregnancy or lactation
The use of nimesulide is contraindicated in the last trimester of pregnancy.
The use of nimesulide can interfere with female fertility, so it is not recommended for women who plan to become pregnant. Like other NSAIDs that inhibit the synthesis of prostaglandins, nimesulide can cause premature closure of the botatal duct, pulmonary hypertension, oliguria, and oligohydramnios. There is an increased risk of bleeding, uterine atony and peripheral edema. Considering also the lack of data on the use of the drug during pregnancy, it is not recommended to prescribe nimesulide in the I and II trimester of pregnancy.
Since it is not known whether nimesulide passes into breast milk, its use is contraindicated during lactation.
The ability to influence the reaction rate when driving vehicles or working with other mechanisms
During treatment, care must be taken while driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Nise drug interactions

With simultaneous use with warfarin and similar anticoagulants, acetylsalicylic acid, there is an increased risk of bleeding.
The simultaneous use of nimesulide and furosemide requires caution in the treatment of patients with impaired renal and cardiac function.
NSAIDs reduce the clearance of lithium, which leads to an increase in the concentration of lithium in the blood plasma and an increase in its toxicity. Therefore, with the simultaneous use of nimesulide and lithium, it is necessary to carefully monitor the concentration of lithium in the blood plasma.
With the simultaneous use of nimesulide with digoxin, theophylline, glibenclamide, ranitidine, antacids, no clinically significant interaction was noted.
Nimesulide inhibits the action of the CYP 2C9 enzyme. Therefore, the concentration in the blood plasma of drugs that are affected by this enzyme can be increased while using them with nimesulide.
Caution must be exercised if the drug is taken less than a day after or a day before the use of methotrexate, since the concentration of methotrexate in the blood serum and its toxicity increase.
It is possible to increase the nephrotoxicity of cyclosporins with simultaneous use with nimesulide.

Overdose of the drug Nise, symptoms and treatment

symptoms: lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, hypertension (arterial hypertension), acute renal failure, respiratory depression, anaphylactoid reactions and coma may also occur.
Treatment. There is no specific antidote. In case of overdose, symptomatic therapy should be carried out. Patients during the first 4 hours need to wash the stomach and take activated charcoal. Hemodialysis is not effective. Careful monitoring of liver and kidney function is necessary.

Storage conditions of the drug Nise

In a dry, dark place at a temperature of 15-25 °C.

List of pharmacies where you can buy Nise:

Saint Petersburg

Nise (active ingredient nimesulide)- a drug of anti-inflammatory, antipyretic and analgesic action. Effectively relieves the symptoms of the disease, but does not affect the root cause of the disease.

Release form

The medicine is produced in the following forms:

In the form of tablets;
In the form of a gel or cream for external use;
In the form of granules and powder for suspension;
In the form of ampoules for the preparation of solutions for injections;
In the form of candles.

Indications for use

Nise tablets are prescribed for:

Any type of arthritis;
Exacerbation of gout;
joint problems;
Spondylitis;
All types of osteochondrosis and radicular syndrome;
Inflammation of ligaments and tendons;
Consequences of operations and injuries;
Neck pain and sprains;
Various pains (headache, toothache, arthralgia);
Reduced pressure.

Suspensions are used:

For the treatment of osteoarthritis;
With severe pain in the back and lower back;
After injuries and dangerous stretch marks;
With toothache;
With algomenorrhea.

The gel is effective:

With chronic diseases of the musculoskeletal system;
With articular syndrome;
For the treatment of osteochondrosis and arthrosis;
With a rupture of the tendons;
For the relief of severe muscle pain;
To relieve inflammation in tissues;
For severe injuries.

Contraindications for use

If you are allergic to the components of the drug;
Patients with asthma;
With ulcerative formations on the gastric mucosa;
At the time of bleeding;
With inflammation in the intestines;
If the patient has impaired blood clotting;
With insufficiency in the kidneys and liver;
Patients suffering from alcoholism and drug addiction;
With hyperkalemia;
Pregnant and lactating women.

Nise in the form of a gel can have a negative effect on:

Polyposis of the nasal sinuses;
an ulcer in the stomach;
Dermatosis;
Various lesions on the skin;
Renal failure in a severe stage.

Use of medication during pregnancy

prohibited for use during pregnancy and breastfeeding. If this drug was prescribed by a doctor during lactation, then the child should be transferred to special formulas for feeding. Experts advise women to stop using Nise at the stage of pregnancy planning (preferably a few months before conceiving a child).

Side effects of Nise tablets and suspension

An incorrectly calculated dose of the drug or individual intolerance by the patient of its components leads to the occurrence of side effects. From the lymphatic system, they manifest themselves as follows:

anemia;
the occurrence of eosinophilia;
thrombocytopenia;
agranulocytosis;
pancytopenia.

External symptoms are expressed in:

profuse rash and severe itching;
urticaria;
swelling of the skin;
Stevens-Johnson syndrome;
exudative erythema;
Lyell's syndrome.

The nervous system also experiences discomfort. Arise:

nausea and vomiting;
constipation;
gastritis;
diarrhea;
bleeding in the stomach;
damage to the mucous membranes;
stomatitis;
flatulence.

Among other things, there are:

general malaise of the body;
problems with urination;
dysuria;
bronchial asthma;
tachycardia and increased pressure;
loss of vision;
allergy attacks and anaphylactoid reactions.

Side effects from using Nise gel and ointment

In these forms, the drug has its own specific side effects:

itching and rash;
burning on the skin;
irritation;
peeling of the skin;
erythema.

If you experience any side effects from the use of Nise, you must immediately seek advice from a specialist. The doctor will either adjust the dosage of the medication or stop the course of treatment.

Basic Precautions When Taking Tablets

In some cases, the use of Nise is prescribed with special care:

With diseases of the stomach;
With low blood clotting;
Elderly patients;
With liver diseases;
If the patient has abdominal pain and dark urine;
With violations of cardiac activity;
With violations of the kidneys.

Patients with diabetes are advised to use the drug in the form of a suspension with extreme caution. This is due to the fact that it contains sucrose.

Transport management at the time of treatment

When taking pain pills, Nise is better refuse from activities that require increased concentration. For example, driving a car. Nise in the form of a gel does not cause inhibition of reactions and does not affect the safety of driving.

Tablets Nise instructions for use

Nise tablets are taken before meals with plenty of water. Depending on the age of the patient, the dosage of the drug is as follows:

Adults: no more than 100 mg per day. In rare cases, doctors allow you to increase the dose to a maximum of 400 mg.
Adolescents from 14 years old: with a body weight of more than 40 kg, the daily dose of an adult is allowed - 100 mg. Nise dispersible tablets are dissolved in a teaspoon of pure water and taken after meals. In this form, the drug is prescribed to adults and, in extreme cases, to adolescents from 14 years of age.

Gel Nise instructions for use

The drug in the form of a gel has its own nuances of use:

The gel must be applied to clean, undamaged skin;
The amount of gel should be moderate (no more than 3 cm according to a special column for measuring the dosage, which is attached to the medicine);
The gel is applied to the most painful part of the body and rubbed with massaging movements;
Gel Nise is used no more than 3 times a day.

Interaction with other drugs

Parallel reception of Nise is possible with drugs of these groups:

diuretics;
nonsteroidal drugs;
anticoagulants;
lithium preparations;
hypoglycemic drugs.

However, the expediency of such a reception must be confirmed by a doctor.

drug overdose

An excess of drug components in the human body threatens with complications:

impaired renal function;
The mucous membranes of the stomach are irritated;
There are problems with breathing;
The pressure rises;
Violent convulsions are observed.

In such situations, emergency therapy will help. The patient is given a gastric lavage and activated charcoal to absorb the excess substance in the blood. Until the symptoms of an overdose completely subside, the patient should be observed by a specialist.

Alcohol compatibility

In the process of treatment with Nise, it is worth refuse from the use of alcoholic beverages. Alcohol in combination with the components of the drug leads to irreversible liver damage and poses a threat to the patient's life.

Storage method and expiration date

Nise tablets are stored in a dark, dry place at a temperature not exceeding 25 degrees, no more than 3 years from the date of manufacture indicated on the package.

Gel Nise must not be stored in the refrigerator or frozen. Its storage temperature should not exceed 20 degrees. The shelf life of the drug in the form of a gel is 2 years from the date of manufacture.

Price

The cost of the drug varies depending on the form of release:

In the form of tablets of 100 mg - the price for 20 pieces is 180-190 rubles.
In the form of a gel 1% - 160-170 rubles per tube of 20 gr.
In the form of a gel - 270-300 rubles per tube of 50 gr.

Nise is available by prescription.

Analogues

Means with a similar action to Nise exist both from Russian and foreign manufacturers:

Nimesil;
Nimid;
Nimesulide;
ibuprofen;
Aponil;
Nimegesic;
Remisid;
Nimika;
Cockstral.