How to take rigevidon not to get pregnant. Rigevidon contraceptive - instructions, use during pregnancy and reviews. Release form, composition and packaging

Content

For contraception and protection from pregnancy, doctors prescribe Rigevidon to women. This is a tablet medicine taken in courses equal to the average menstrual cycles. Its use is indicated for women of childbearing age. From the instructions for use, you will learn about contraindications, side effects, restrictions.

Application instruction of Rigevidon

According to the accepted medical classification, Rigevidon contraceptive pills are monophasic oral contraceptives prescribed to regulate sexual life and protect against pregnancy. The active components of the composition are the hormones ethinylestradiol and levonorgestrel, which enter the body in such an amount that ovulation does not occur.

Composition and form of release

The drug is available only in the form of tablets for oral administration. Characteristics and composition of Rigevidon:

Pharmacodynamics and pharmacokinetics

The drug is a combined monophasic hormonal agent. The progestogen component is levonorgestrel. The substance acts at the level of gonadotropic receptors without prior metabolism. Levonorgestrel prevents the release of hormones (LH and FSH) responsible for egg maturation from the hypothalamus, inhibits the production of gonadotropic hormones by the pituitary gland and inhibits the maturation and release of an egg ready for fertilization (ovulation).

Ethinylestradiol belongs to estrogenic elements, enhances the contraceptive effect, maintains an increased viscosity of cervical mucus, which slows down the speed of spermatozoa. In addition to the protective effect, the drug, with regular use, normalizes the menstrual cycle, prevents the development of gynecological diseases, including tumors.

Ethinylestradiol passes through the liver, reaches a maximum concentration after 26 hours. It is excreted in 12 hours from the blood plasma. The metabolism of the component occurs in the liver, intestines, metabolites enter the intestine with bile, where they are disintegrated by intestinal bacteria. Levonorgestrel is absorbed within 4 hours after ingestion, reaches a maximum concentration in two hours, and is excreted in 32 hours. The substance is excreted by the kidneys (to a lesser extent) and intestines with urine and feces, excreted in breast milk.

Indications for Rigevidon's use

The main indication for the use of Rigevidon is oral contraception, protection against unwanted pregnancy. Other factors in the use of an oral hormonal drug are functional menstrual disorders, including dysmenorrhea without an organic cause and dysfunctional metrorrhagia, premenstrual tension syndrome.

How to take Rigevidon

Tablets are intended for oral administration, they should not be chewed, it is advisable to drink a small amount of water. For the initial use, Rigevidon is prescribed from the first day of menstruation on a tablet / day for a 21-day course at the same time of day. Then a break is made for a week for the course of menstrual-like bleeding. The next course begins on the eighth day after a seven-day break. The start of taking the drug falls on the same day of the week.

After an abortion, the reception begins on the day of the operation or the next day. After childbirth, the drug is prescribed only to those women who are not going to breastfeed. Reception is appointed from the first day of menstruation. If a tablet is missed, it can be taken within 12 hours. If 36 hours have passed, contraception is considered unreliable. To avoid intermenstrual bleeding, continue taking from the already started package, except for the missed doses. If you miss the use of the drug, you should additionally use another method of contraception (barrier).

special instructions

In the instructions for use, it is useful to study the special instructions section containing the rules and recommendations for taking. Some excerpts:

Before the start of use and every six months, the patients undergo a general medical and gynecological examination (cytology, smear and cervical analysis, mammary glands, blood glucose, cholesterol, liver function, blood pressure, urinalysis).
You can take oral contraceptives no earlier than six months after suffering viral hepatitis (liver functions are assessed before the appointment).
If there are sharp pains in the abdomen, hepatomegaly, signs of internal bleeding, doctors may suspect liver tumor disease, the drug is canceled.
If vomiting or diarrhea occurs, the drug is continued, combined with non-hormonal contraceptives.
Women who smoke are at an increased risk of developing cardiovascular diseases with consequences in the form of myocardial infarction, stroke (the risk increases over the age of 35 and with a large number of cigarettes smoked).
The use of Rigevidon is stopped when migraine-like, severe headaches, phlebitis, phlebothrombosis, jaundice, cerebrovascular disorders, stabbing pains during breathing, a sharp decrease in visual acuity, suspected thrombosis or heart attack occur.

During pregnancy

The drug is canceled three months before the planned or immediately after the onset of pregnancy, while carrying a child and breastfeeding an infant, it is contraindicated. This is due to the increased content of hormones in the blood, which can adversely affect the development of the fetus. Both active components are excreted in breast milk and can harm the newborn.

In childhood

The drug is contraindicated for use in children and adolescents under 18 years of age. This is due to the content in the composition of active hormones that affect puberty and inhibition of ovulation. Rigevidon cannot be prescribed independently, this should be done by a doctor according to strict indications and after a thorough examination of the patient's body.

Alcohol compatibility

According to doctors, Rigevidon and alcohol can be combined, but it is better to separate the time of taking pills and drinking alcohol. There were several cases where ethanol and alcohol-containing drinks or drugs reduced the effectiveness of the drug. Such cases coincided with a large amount of alcohol consumed. Moderation must be observed for reliable protection.

drug interaction

While taking Rigevidon, some combinations with drugs are prohibited or are in the “take with caution” group. Combinations and risks:

barbiturates, antiepileptic drugs, sulfonamides, Phenytoin, Carbamazepine, pyrazolone derivatives increase the metabolism of steroid hormones;
antimicrobial agents reduce contraceptive effectiveness by changing the intestinal microflora;
the drug increases the bioavailability, hepatotoxicity of tricyclic antidepressants, beta-blockers and Maprotiline, insulin;
Rigevidon reduces the effectiveness of Bromocriptine.

Side effects of Rigevidon

According to the reviews of patients who took Rigevidon, it is well tolerated. Possible side effects are:

nausea, vomiting, diarrhea;
headache;
hardening of the mammary glands;
change in body weight;
libido disorders;
sudden change of mood;
swelling of the eyelids, conjunctivitis, impaired visual acuity;
chloasma;
hearing loss;
skin rashes, itching;
calf cramps;
jaundice;
increased frequency of epileptic seizures;
hyperglycemia;
hypertriglyceridemia;
impaired glucose tolerance;
increase in pressure;
thrombosis, venous thromboembolism;
candidiasis, violation of the secretion of the vagina.

Overdose

To date, not a single case of an overdose of Rigevidon and cases of the development of toxic effects from its administration have been described. Prolonged excess of the dose threatens to disrupt the hormonal background. For any strange side effects and suspicion of an inadequate response of the body to treatment, you should consult a doctor for a decision (cancellation of the drug, prescribing another).

Contraindications

The drug is prescribed with caution for epilepsy, depression, gallbladder disease, ulcerative colitis, uterine myoma. Careful use should be observed in patients with mastopathy, tuberculosis, varicose veins, multiple sclerosis, bronchial asthma. Rigevidon contraindications are:

severe liver disease, congenital hyperbilirubinemia;
cholecystitis;
predisposition to thromboembolism, its presence;
breast cancer, endometrial cancer, other malignant tumors;
hyperlipidemia;
arterial hypertension;
endocrine diseases, severe diabetes mellitus;
sickle cell, chronic hemolytic anemia;
vaginal bleeding of unknown origin;
cystic skid;
migraine;
otosclerosis;
idiopathic jaundice;
herpes;
age over 40;
pregnancy, lactation;
hypersensitivity to components.

Terms of sale and storage

You can buy Rigevidon only with a prescription. The drug is stored away from children at temperatures up to 25 degrees for three years.

Rigevidon's analogs

There are several analogues of the drug with the same composition and principle of action. Popular substitutes are:

Yarina - tablets containing drospirenone, ethinyl estradiol;
Regulon is a monophasic contraceptive based on ethinylestradiol, desogestrel;
Jeanine - a dragee with antiandrogenic activity, the composition includes dienogest, ethinyl estradiol.

Regulon or Rigevidon - which is better

Unlike Rigevidon, Regulon contains desogestrel. It also inhibits the synthesis of gonadotropins by the pituitary gland (luteinizing, follicle-stimulating hormones), has an antiestrogenic effect similar to endogenous progesterone, and is characterized by weak anabolic activity. In general, the drugs are similar, the doctor should decide on their appointment.

Price

You can buy Rigevidon through pharmacies or online platforms by presenting a prescription from a doctor. The cost of drugs is affected by the level of the trade margin, the number of tablets in the package. Approximate prices for the drug and its analogues.

Rigevidon is a monophasic oral contraceptive drug.

Release form and composition

Dosage form of release of Rigevidon - coated tablets: white, biconvex, round (in blisters of 21 tablets, in a cardboard box 1 or 3 blisters).

Active substances in 1 tablet:

ethinylestradiol - 0.03 mg;
levonorgestrel - 0.15 mg.

Additional components:

core: colloidal silicon dioxide - 0.275 mg, magnesium stearate - 0.55 mg, talc - 1.1 mg, corn starch - 19.895 mg, lactose monohydrate - 33 mg;
shell: macrogol 6000 - 0.148 mg, sucrose - 22.459 mg, talc - 6.826 mg, carmellose sodium - 0.029 mg, calcium carbonate - 3.006 mg, colloidal silicon dioxide - 0.146 mg, titanium dioxide - 1.706 mg, copovidone - 0.592 mg, povidone - 0.088 mg.

Indications for use

contraception;
premenstrual tension syndrome;
functional disorders of the menstrual cycle (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia).

Contraindications

severe liver disease;
cholecystitis;
congenital increase in serum bilirubin - hyperbilirubinemia (Gilbert, Dubin-Johnson, Rotor syndromes);
cerebrovascular and cardiovascular diseases in severe course (currently or with a burdened history);
familial forms of hyperlipidemia;
thromboembolism and the presence of a predisposition to their development;
liver tumors;
idiopathic jaundice of pregnant women in history;
malignant tumors (mainly endometrial cancer and breast cancer);
arterial hypertension in severe form;
endocrine diseases, including severe diabetes mellitus;
otosclerosis;
sickle cell anemia;
migraine;
hemolytic anemia in a chronic course;
cystic skid;
herpes and / or severe itching of pregnant women;
vaginal bleeding of unknown origin;
age over 40;
pregnancy and lactation;
hypersensitivity to the components of the drug.

The appointment of Rigevidon requires caution in the presence of the following diseases / conditions:

ulcerative colitis;
phlebeurysm;
mastopathy;
tuberculosis;
otosclerosis;
bronchial asthma;
diseases of the kidneys, gallbladder, liver, cardiovascular system;
diabetes;
uterine fibroids;
epilepsy;
depression;
arterial hypertension;
chorea;
multiple sclerosis;
functional disorders of the kidneys;
phlebitis;
hidden tetany;
intermittent porphyria;
adolescence (in the case when there are no regular ovulatory cycles).

Method of application and dosage

Rigevidon should be taken orally with a small amount of water, the tablets should not be chewed.

If hormonal preparations for contraceptive purposes have not been previously used, it is recommended to start taking Rigevidon from the first day of menstruation. Therapy is carried out daily for 21 days, after which they take a break of 7 days, at which time, as a rule, menstrual-like bleeding occurs. Regardless of whether the bleeding has ended, the course is resumed at the end of this period.

A similar scheme is used when switching from another oral contraceptive.

The duration of therapy is determined by the need for contraception.

Features of the start of taking Rigevidon in some cases:

after abortion: on the day or the next day after the abortion;
after childbirth (non-breastfeeding women only): not earlier than the first day of menstruation.

The allowable interval between taking pills is 36 hours. With a longer interruption, the reliability of protection decreases. To avoid the occurrence of intermenstrual bleeding, Rigevidon should be continued from the current package, excluding the missed tablet(s). In this case, additional non-hormonal methods of contraception (for example, barrier ones) should be used.

The doctor determines the regimen for the use of Rigevidon for therapeutic purposes individually.

Side effects

Rigevidon is well tolerated in most cases.

Possible adverse reactions (usually disappear spontaneously): breast engorgement, headache, nausea, vomiting, mood changes, changes in body weight and libido, acyclic spotting; in some cases - visual impairment, swelling of the eyelids, conjunctivitis, discomfort when wearing contact lenses (temporary disorders).

Long-term therapy in very rare cases can lead to the development of such side effects as: jaundice, increased frequency of epileptic seizures, hearing loss, chloasma, generalized itching, calf muscle cramps.

In rare cases, there has been a decrease in glucose tolerance, hypertriglyceridemia, hyperglycemia, increased blood pressure, jaundice, thrombosis and venous thromboembolism, skin rashes, candidiasis, changes in the nature of vaginal secretion, diarrhea, fatigue.

special instructions

Prior to the appointment of Rigevidon, as well as 2 times a year in the future, it is necessary to conduct a general medical and gynecological examination, in particular: a cytological analysis of a smear from the cervix, determination of blood glucose, assessment of the state of the mammary glands, cholesterol and other functional indicators of the liver, urinalysis, control blood pressure.

After suffering viral hepatitis, Rigevidon can be prescribed no earlier than six months later if liver function has returned to normal.

If a liver tumor is suspected (symptoms: sharp pains in the upper abdomen, hepatomegaly and signs of intra-abdominal bleeding), therapy is canceled. In the event of the appearance of functional disorders of the liver during the period of therapy, consultation with a specialist is necessary.

With thromboembolism at a young age and the presence of anamnestic data on increased blood clotting, Rigevidon is not recommended.

In the event of acyclic (intermenstrual) bleeding, therapy should be continued, since most often they stop spontaneously. If this does not happen, or bleeding is repeated, a medical examination is indicated to exclude organic pathologies of the reproductive system.

Smoking women taking the drug increase the likelihood of developing diseases of the cardiovascular system, which can have serious consequences (stroke, myocardial infarction). The risk increases with age and also depends on the number of cigarettes smoked (especially for women over 35).

With a decrease in the absorption of Rigevidon due to diarrhea or vomiting, therapy should not be interrupted, while the additional use of other, non-hormonal contraceptive methods is indicated.

Reasons for discontinuation of the drug:

appearance for the first time or intensification of migraine-like headaches;
the appearance of unusually severe headaches;
a sharp increase in blood pressure;
development of jaundice or hepatitis without jaundice;
increased occurrence of epileptic seizures;
the appearance of early signs of phlebothrombosis or phlebitis (symptoms: swelling of the veins or unusual pain in the legs);
acute deterioration of visual acuity;
the occurrence of generalized itching;
suspected heart attack or thrombosis;
cerebrovascular disorders;
prolonged immobilization;
the appearance of stabbing pains when coughing and / or breathing of unknown origin, a feeling of tightness or pain in the chest;
planning of surgical intervention (approximately 1.5 months in advance);
planning (about 3 months in advance) and pregnancy.

drug interaction

With the combined use of Rigevidon with certain substances / preparations, the following effects may develop:

pyrazolone derivatives, barbiturates, sulfonamides, some drugs with antiepileptic action (phenytoin, carbamazepine): increased metabolism of the active substances that make up Rigevidon;
tricyclic antidepressants, maprotiline, beta-blockers: increased toxicity and bioavailability of these drugs;
some drugs with antimicrobial action, including ampicillin, neomycin, rifampicin, chloramphenicol, sulfonamides, polymyxin B, tetracyclines: a decrease in the contraceptive effect of Rigevidon (due to changes in the intestinal microflora);
oral hypoglycemic drugs and insulin: interaction development (in some cases, a change in their dosing regimen is required);
anticoagulants, derivatives of indandione or coumarin: development of interaction (in some cases, an additional determination of the prothrombin index is required, as well as a change in the dosing regimen of the anticoagulant);
drugs with a potential hepatotoxic effect: increased hepatotoxicity, especially in patients over 35 years of age;
bromocriptine: decrease in its action.

Terms and conditions of storage

Keep out of the reach of children at temperatures up to 25°C.

Shelf life - 3 years.

Found a mistake in the text? Select it and press Ctrl + Enter.

Application instruction to Rigevidon

Registration number:

P N012676/02

Tradename: RIGEVIDON ®

International non-proprietary name or grouping name: Ethinylestradiol + Levonorgestrel

Dosage form:

coated tablets

COMPOUND
Active substances:
Ethinylestradiol: 0.03 mg
Levonorgestrel; 0.15 mg
Excipients:
- in the tablet core: colloidal silicon dioxide, magnesium stearate, talc, corn starch, lactose monohydrate;
- in a tablet shell: sucrose, talc, calcium carbonate, titanium dioxide, copovidone, macrogol 6000, colloidal silicon dioxide, povidone, carmellose sodium.

Description
White, round, biconvex film-coated tablets.

Pharmacotherapeutic group:

contraceptive (estrogen + gestagen)

ATC code: G03AA07.

PHARMACOLOGICAL PROPERTIES
Pharmacodynamics
Rigevidon is an oral monophasic combined estrogen-progestin contraceptive drug.
When taken orally, it inhibits the pituitary secretion of gonadotropic hormones.
The contraceptive effect is associated with several mechanisms. As a progestogen component (progestin), it contains a derivative of 19-nortestosterone - levonorgestrel, which is superior in activity to the hormone of the corpus luteum progesterone (and the synthetic analogue of the latter - pregnin), acts at the receptor level without preliminary metabolic transformations. The estrogenic component is ethinylestradiol. Under the influence of levonorgestrel, a blockade of the release of releasing hormones (LH and FSH) of the hypothalamus occurs, inhibition of the secretion of gonadotropic hormones by the pituitary gland, which leads to inhibition of the maturation and release of an egg ready for fertilization (ovulation). The contraceptive effect is enhanced by ethinyl estradiol. Maintains high viscosity of cervical mucus (makes it difficult for spermatozoa to enter the uterine cavity). Along with the contraceptive effect, when taken regularly, it normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, incl. tumor nature.
Pharmacokinetics
Levonorgestrel is rapidly absorbed (less than 4 hours). Levonorgestrel does not have a first pass effect through the liver. With the combined use of levonorgestrel with ethinyl estradiol, there is a relationship between dose and maximum plasma concentration. TC max (time to reach maximum concentration) of levonorgestrel is 2 hours, T 1/2 (half-life) - 8-30 hours. (average 16 hours). Most of levonorgestrel binds in the blood to albumin and SHBG (Sex Hormone Binding Globulin).
Ethinylestradiol is rapidly and almost completely absorbed from the intestine. Ethinyl estradiol is characterized by the effect of the primary passage through the liver, TC max is 1.5 hours, the half-life is about 26 hours.
When administered orally, ethinylestradiol is excreted from the blood plasma within 12 hours, the elimination half-life is 5.8 hours.
The metabolism of ethinylestradiol is carried out in the liver and intestines. Ethinyl estradiol metabolites are water-soluble products of sulfate or glucuronide conjugation, enter the intestine with bile, where they are disintegrated by intestinal bacteria.
Both components (levonorgestrel and ethinylestradiol) are excreted in breast milk. Active substances are metabolized in the liver, T 1/2 is 2-7 hours.
excretion of levonorgestrel is carried out by the kidneys (60%) and through the intestines (40%); ethinylestradiol - by the kidneys (40%) and through the intestines (60%).

INDICATIONS FOR USE
Oral contraception, functional menstrual disorders (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia, premenstrual syndrome).

CONTRAINDICATIONS
Hypersensitivity to the components of the drug, pregnancy, lactation, severe liver disease, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), cholecystitis, the presence or history of severe cardiovascular and cerebrovascular changes, thromboembolism and predisposition to them , liver tumors, malignant tumors, especially breast or endometrial cancer; familial forms of hyperlipidemia, severe forms of arterial hypertension, severe forms of diabetes mellitus and other diseases of the endocrine glands, sickle cell anemia, chronic hemolytic anemia, hydatidiform drift, age over 40 years, vaginal bleeding of unknown etiology, migraine, otosclerosis; history of idiopathic jaundice of pregnant women, severe pruritus of pregnant women, herpes of pregnant women.

CAREFULLY
Liver and gallbladder diseases, epilepsy, depression, ulcerative colitis, uterine fibroids, mastopathy, tuberculosis, kidney disease, adolescence (without regular ovulatory cycles).
In the presence of diabetes mellitus, diseases of the cardiovascular system, arterial hypertension, impaired renal function, varicose veins, phlebitis, otosclerosis, multiple sclerosis, epilepsy, chorea minor, intermittent porphyria, latent tetany, bronchial asthma, the prescription of the drug also requires caution.

PREGNANCY AND LACTATION
During pregnancy and lactation, the drug is contraindicated.

METHOD OF APPLICATION AND DOSES
Apply inside, without chewing and drinking a small amount of liquid.
If hormonal contraception was not performed during the previous menstrual cycle, contraception with Rigevidon is started from the first day of menstruation, taking 1 tablet daily for 21 days, at the same time of day.
This is followed by a 7-day break, during which menstrual-like bleeding occurs. The next 21-day cycle of taking tablets from a new package containing 21 tablets must be started the day after the 7-day break, i.e. on the eighth day, even if the bleeding has not stopped. Thus, the start of taking the drug from each new package falls on the same day of the week.
When switching to taking Rigevidon from another oral contraceptive, a similar scheme is used. The drug is taken for as long as there is a need for contraception.
After an abortion, it is recommended to start taking the drug on the day of the abortion or the day after the operation.
After childbirth, the drug can be prescribed only to women who are not breastfeeding; you should start taking contraceptives no earlier than the first day of menstruation. During lactation, the use of the drug is contraindicated.
missed pills; the missed tablet should be taken within the next 12 hours. If 36 hours have passed since the last pill, contraception is unreliable. In order to avoid intermenstrual bleeding, the drug should be continued from the already started package, with the exception of the missed tablet(s). In cases of skipping pills, it is recommended to additionally use another, non-hormonal method of contraception (eg, barrier).
For medicinal purposes; the dose of Rigevidon and the scheme of application are selected by the doctor in each case individually.

SIDE EFFECT
The drug is usually well tolerated.
Possible side effects of a transient nature, spontaneously passing: nausea, vomiting, headache, breast engorgement, changes in body weight and libido, mood changes, acyclic spotting, in some cases - swelling of the eyelids, conjunctivitis, blurred vision, discomfort when wearing contact lenses (these phenomena are temporary and disappear after discontinuation without prescribing any therapy).
With prolonged use, chloasma, hearing loss, generalized itching, jaundice, cramps of the calf muscles, and an increase in the frequency of epileptic seizures can very rarely occur. Rarely observed hypertriglyceridemia, hyperglycemia, decreased glucose tolerance, increased blood pressure (BP), thrombosis and venous thromboembolism, jaundice, skin rashes, changes in the nature of vaginal secretion, vaginal candidiasis, fatigue, diarrhea.

OVERDOSE
Cases of development of toxic effects due to overdose are unknown.

INTERACTION WITH OTHER DRUGS
Barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, pyrazolone derivatives can increase the metabolism of the steroid hormones that make up the drug.
A decrease in contraceptive efficacy can also be observed with simultaneous administration with certain antimicrobial drugs (ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines), which is associated with a change in the microflora in the intestine.
When using anticoagulants, coumarin or indandione derivatives, it may be necessary to additionally determine the prothrombin index and change the dose of the anticoagulant.
When using tricyclic antidepressants, maprotiline, beta-blockers, their bioavailability and toxicity may increase.
When using oral hypoglycemic drugs and insulin, it may be necessary to change their dose.
When combined with bromocriptine, the effectiveness of bromocriptine is reduced.
When combined with drugs with a potential hepatotoxic effect, for example, with the drug dantrolene, an increase in hepatotoxicity is observed, especially in women over 35 years of age.

SPECIAL INSTRUCTIONS
Before starting contraception and, thereafter, every 6 months. a general medical and gynecological examination is recommended, including a cytological analysis of a smear from the cervix, an assessment of the condition of the mammary glands, determination of blood glucose, cholesterol and other indicators of liver function, blood pressure control, urinalysis).
The appointment of Rigevidon to women with thromboembolic diseases at a young age and an increase in blood clotting in a family history is not recommended.
The use of oral contraception is allowed no earlier than 6 months after viral hepatitis, subject to the normalization of hepatic functions.
With the appearance of sharp pains in the upper abdomen, hepatomegaly and signs of intra-abdominal bleeding, a liver tumor may be suspected. If necessary, the drug should be discontinued.
In case of deterioration of hepatic functions while taking Rigevidon, it is necessary to consult a therapist.
With the appearance of acyclic (intermenstrual) bleeding, Rigevidon should be continued, since in most cases these bleedings stop spontaneously. If acyclic (intermenstrual) bleeding does not disappear or recurs, a medical examination should be carried out to rule out organic pathology of the reproductive system.
In case of vomiting or diarrhea, the drug should be continued, additionally using another, non-hormonal method of contraception.
Smoking women taking hormonal contraceptives have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and with the number of cigarettes smoked (especially in women over 35).
The drug should be discontinued in the following cases:
- when a migraine-like headache appears for the first time or increases, or an unusually severe headache appears;
- with the appearance of early signs of phlebitis or phlebothrombosis (unaccustomed pain or swelling of the veins in the legs);
- in case of jaundice or hepatitis without jaundice;
- with cerebrovascular disorders;
- with the appearance of stabbing pains of unclear etiology when breathing or coughing, pain and a feeling of tightness in the chest;
- with acute deterioration of visual acuity;
- in case of suspected thrombosis or infarction;
- with a sharp increase in blood pressure;
- in case of generalized itching;
- with an increase in epileptic seizures;
- 3 months before the planned pregnancy, approximately 6 weeks before the planned surgical intervention, with prolonged immobilization.
- in the presence of pregnancy.

EFFECT OF THE DRUG ON THE ABILITY TO DRIVE A CAR AND OTHER MECHANISMS
Taking the drug does not affect the ability to drive a car and other mechanisms, work with which is associated with an increased risk of injury.

RELEASE FORM
Pills;
21 tablets in a blister made of PVC / PVDC film and aluminum foil;
1 or 3 blisters in a cardboard box with instructions for use.

STORAGE CONDITIONS
At a temperature of 15-30 °C.
Keep the drug in a place inaccessible to children!

BEST BEFORE DATE
5 years. Do not use after the expiration date.

TERMS AND CONDITIONS OF DISCOUNT FROM PHARMACIES
On prescription.

MANUFACTURER
OJSC "Gedeon Richter",
1103 Budapest, st. Demrei, 19-21, Hungary.
Consumer claims should be sent to:
Moscow Representative Office of JSC "Gedeon Richter"

Regividon is the best solution!

Advantages: No side effects, reasonable price, compatibility with other drugs.

Cons: not found

After the birth of two wonderful toddlers, my husband and I thought about contraception. After consulting with my gynecologist, I decided to opt for Rigevidon. It is convenient that you can swallow them even without drinking water. The doctor immediately warned that you should take a pill every day at the same time and not skip doses in any case. Most of all, I was probably afraid that with taking the pills, excess weight would come, but nothing like that happens to this day. The only thing was that at the very beginning of the reception there was a slight nausea, but then it passed. Menstruation comes without delay. I will say that I have been using Rigevidon for more than five years, occasionally taking small breaks to rest the body, and during all this time there were no problems. The drug works great.

No effect is worth the health spent, avoid

Benefits: Effective contraception, price

Disadvantages: Huge harm to health and strong side effects

She refused hormonal contraceptives, because she drank Rigevidon and found out for herself what harm they cause. Hormonal contraceptives are guaranteed to be effective, which is why they were so popular, and now people understand how harmful they are. I used them for a while, and was happy - the pills really work, they are very inexpensive, besides. But over time, I realized that a lot of the problems that I had were caused by this particular drug. We start with the mood - a hysterical vixen, who is irritated by everything and always, yells, cries all the time and behaves inappropriately - here's my portrait after 2 months of taking Rigevidon. And by nature, I’m rather even a phlegmatic person, I don’t suffer from emotionality at all. The second is weight. A painful question, because in 3 months of use I gained not a couple of kilograms, but 9.2 kg !!! I went to the gym, rocked, to no avail, I usually lose weight easily, but here my legs and arms are thinner (the muscles go away), and the fat on my stomach is nowhere. This is due to progesterone, the amount of which increases greatly when taking hormonal pills. The third is the pressure, which has increased from my usual 110 to 150! So it won't take long to become hypertensive. Then there was a whole bunch of things, I won’t paint, briefly: frequent thrush, terrible chest pains, painful periods and PMS with terrible discomfort, acne all over my face, and the highlight of the program is jaundice, which I never had. How do I know that drug cause? Analyzes, banal tests for hormones and an intelligent gynecologist. Then all these problems had to be eliminated for a very long time, because girls - take care of yourself and do not use such muck.

Strong hormonal drug

Advantages: reasonable price

Disadvantages: side effects, weight gain, irritability appears

A few months ago, my sister was diagnosed with fibromyoma and, after a while, she began to increase in size. The doctor she went to, after checking the hormonal levels and other tests, for some reason prescribed Rigevidon for her. The motivation was as follows: it normalizes the monthly cycle (which really went astray, there were blood smears), it will prevent unplanned pregnancies and slow down the development of the fibromatous node. The drug itself is not bad, available in pharmacies, the price is reasonable. But, there is one significant downside. My sister and I saw each other after 2 months and I did not immediately recognize her. She gained 7 kg in 2 months! Then she said that her libido had weakened and she became nervous. As for fibroids, there was no noticeable result in 2 months. As a result, they refused Regividon, and my sister is taking another drug.

If you are going to use Rigevidon as a contraceptive, before you start taking it, you should probably find out - is it suitable for you personally as a method of contraception? To analyze all the pros and cons of this remedy, find out how it can affect your health, what diseases it treats, is it possible to drink alcohol if you are taking Rigevidon, does it make sense to replace it with next-generation contraceptives, after what time should you stop taking Rigevidon?

Rigevidon belongs to the group of monophasic oral contraceptives. This means that each tablet contains the same amount of hormones - estrogen and progestogen - for all days of hormone therapy. But besides this, Rigevidon contains ferrous iron, which helps to avoid a drop in hemoglobin during heavy periods.

Features of the drug

"Rigevidon" includes the following hormones:

estrogen component- ethinylestradiol at a dosage of 30 mcg;
progestogen component- levonorgestrel at a dosage of 150 mcg.

In the package "21 + 7" red tablets contain ferrous iron. Their reception allows you to make up for blood loss. This is especially true for women with heavy menstruation, for example, with endometrial hyperplasia or endometriosis, uterine fibroids. If the package contains only 21 tablets, there is no iron in the composition.

Operating principle

"Rigevidon" affects the central nervous system and genital organs of a woman, like all other drugs from a series of hormonal contraceptives. Namely:

levonorgestrel - inhibits the growth and maturation of a new follicle, as a result of which ovulation cannot occur;
ethinylestradiol- affects the cervical mucus, thickening it and thereby creating a mechanical obstacle to the advancement of spermatozoa.

Against the background of such hormonal changes, the endometrium inside the uterus becomes thinner. This prevents the implantation (attachment) of the fetal egg to the wall in case of fertilization (for example, if the schedule for taking pills is violated). It also ensures less heavy menstruation. Sometimes they are presented only by spotting the discharge for three to five days.

Advantages

The main purpose of "Rigevidon" is contraception. But in parallel, it can have a therapeutic effect, so it is often prescribed after surgery, after abortion, to stabilize the hormonal background. "Rigevidon" has the following properties:

reduces the likelihood of recurrent ectopic pregnancy;
reduces the frequency of formation of functional;
to carry out the prevention of venous blood stagnation in the small pelvis;
the drug has iron in the composition of dummy tablets.

Based on the principles of action of the remedy, indications for the use of "Rigevidon" are established. Namely:

after surgery for an ectopic pregnancy;
with surgical removal of an ovarian cyst;
after successful conservative treatment of functional ovarian cysts;
with endometriosis as the main treatment;
for contraception;
after abortions, miscarriages, childbirth;
for the prevention of anemia with a tendency to heavy menstruation;
may be used to stop bleeding, especially in adolescent girls.

After taking "Rigevidon", menstruation is quickly restored, there is no excessive inhibition of one's own ovarian function. This is due to a break in taking the pills, during which the release of hormones by the ovaries and the pituitary gland of the brain occurs.

Instructions for use "Rigevidon"

Contraceptive pills "Rigevidon" should be taken according to the generally accepted instructions for oral contraceptives. Cases of drug overdose are not written. The admission rules are as follows:

from the first day of menstruation;
at the same strictly fixed time;
for 21 days with a seven-day break (or 28 without a break in a 21+7 package).

Depending on the clinical situation, the regimens for taking "Rigevidon" may differ slightly.

After similar drugs. If a girl decides to switch to the drug from other oral contraceptives, Rigevidon should be started immediately after the end of the old pills.
After patches, rings. If previously transdermal patches or a vaginal ring were used for contraception, Rigevidon should be started on the day the previous method of contraception was removed.
After pregnancy. If the interruption (for example, after an abortion or miscarriage) occurred at an early date, the start of taking the drug should be on the same day or the next. If a woman decides to take "Rigevidon" after childbirth, this can be done already on the 28th day, taking into account the fact that lactation is not supported, since the drug actively penetrates into breast milk. After miscarriages for long periods (after 16 weeks), the first pill should be started on the 28th day, if necessary - earlier.

The drug is not used to terminate a pregnancy, it only prevents conception and implantation of the ovum, so it makes no sense to start taking it immediately after unprotected sex, not taking into account the day of the cycle.

If you violated the scheme

In the case when one tablet is missed, it is necessary to determine how much time has passed. Further actions proceed from this:

up to 36 hours - in this case, you must take the missed tablet, and drink the next one at the usual time;
more than 36 hours - in this case, it makes no sense to take the missed pill, you only need to drink the next one on the schedule; but for the next week, additional methods of contraception, such as a condom, should be used.

To shorten the duration of the menstrual cycle and to delay periods, you can start the next pack without taking the pacifiers. But it is recommended to do this no more than two or three cycles in a row, otherwise the risk of breakthrough bleeding increases.

What could be the consequences

Side effects of "Rigevidon" are not bright, usually pass on the second or third package. The main ones are the following:

headache;
excessive fatigue;
irritability;
nausea;
weight gain by 1-2 kg;
decreased sexual desire for a partner;
liver enzymes may be elevated in tests;
sometimes there is dryness of the genitals, a tendency to thrush.

If a woman decides to take Rigevidon without interruption for several years, it is necessary to regularly monitor the indicators of general and biochemical blood tests to prevent serious complications.

Who is denied admission

"Rigevidon" is not an absolutely safe drug. He has a list of contraindications. The main ones include the following:

disruption of the liver and biliary tract;
severe arterial hypertension;
with ever recorded migraine attacks;
with jaundice, itching of pregnant women in anamnesis in a woman;
with epilepsy and mental illness;
with thrombosis and thrombophlebitis in a woman and even her close relatives.

It is also not recommended to take after 40 years and especially during menopause, when smoking, with unspecified bleeding from the vagina. It is not the drug of choice in adolescents with an unestablished menstrual cycle.

What will be the monthly and when to expect them

Not always after taking Rigevidon, menstruation comes on time and there are no failures. The body needs time to get used to the intake of sex hormones from the outside in a constant amount. After all, they usually stand out in a pulsed mode and the readings differ significantly even during the day.

The next menstrual-like discharge should normally appear after the withdrawal of active tablets, while taking pacifiers. But this is not always the case, and this is allowed. Most often, various disorders occur in the first two to three months of taking oral contraceptives. The following deviations are possible.

The beginning of menstruation is still on active tablets. In this case, it is necessary to continue taking it until the end of the package, or, with the onset of spotting, take a seven-day break with pacifiers.
delay after the whole package. Sometimes in the first two or three months while taking pacifiers, spotting may be absent, there is nothing pathological in this, but for control, you should be examined by a doctor and be sure to exclude pregnancy (especially if there is nausea, engorgement of the mammary glands).
Spotting throughout the cycle. While the body gets used to the new regimen, brownish light discharge may periodically appear.
Instead of monthly, scanty discharge. Very often, while taking hormonal drugs, menstruation becomes very scarce and sometimes only daubs are presented, this is normal.
Bleeding on any day of the cycle. In this case, it is better to immediately consult a doctor to prescribe treatment or discontinue the drug; in parallel, you can take any hemostatic drugs (Etamzilat, Dicinon, "", "Ascorutin", "Tranexam").

Rigevidon is a combined hormonal drug of the group of monophasic oral contraceptives. The active substances of Rigevidon are ethinylestradiol and levonorgestrel.

They act at the receptor level, blocking the release of the hormones FSH and LH from the hypothalamus, which inhibits the process of ovulation and prevents the egg from maturing. The estrogenic active ingredient is ethinylestradiol, which enhances the action of levonorgestrel.

In this article, we will consider why doctors prescribe Rigevidon, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Rigevidon can be read in the comments.

Composition and form of release

Rigevidon is produced in tablets, packaged in blisters of 21 pieces, 3 or 1 blisters per pack.

The composition of Rigevidon includes the main components: ethinylestradiol and levonorgestrel.

Clinical and pharmacological group: monophasic oral contraceptive.

What is Rigevidon used for?

According to the instructions, Rigevidon can be used for the following indications:

for the purpose of oral contraception;
to relieve premenstrual tension syndrome.

It is also used for functional disorders of the menstrual cycle, in particular, dysfunctional metrorrhagia and dysmenorrhea caused by non-organic causes.

pharmachologic effect

Rigevidon belongs to the group of combined oral contraceptives. Effectively prevents pregnancy.

The active components of Rigevidon prevent fertilization and pregnancy, helping to suppress ovulation, increase the viscosity of cervical mucus, and reduce the susceptibility of the endometrium to the blastocyst.
Rigevidon also, with regular use, reduces the risk of developing gynecological diseases, reduces the frequency of dysmenorrhea, reduces blood loss during menstruation, and reduces the risk of ectopic pregnancy.

After discontinuation of the drug, fertility is restored in 1-3 cycles.

Instructions for use

According to the instructions for use, Rigevidon should be taken orally with a small amount of liquid. Tablets should not be chewed.

If during the previous menstrual cycle hormonal contraception was not carried out, then Rigevidon for the purpose of contraception is prescribed from the 1st day of menstruation, 1 tablet daily for 21 days. This is followed by a 7-day break, during which menstrual-like bleeding occurs. The next 21-day cycle of taking tablets from a new package containing 21 tablets must be started the day after the 7-day break, i.e. on the 8th day, even if the bleeding has not stopped. Thus, the start of taking the drug from each new package falls on the same day of the week.
When switching to taking Rigevidon from another oral contraceptive, a similar scheme is used. The drug is taken for as long as there is a need for contraception.
Reception of Rigevidon after an abortion is recommended to start on the day of the abortion or the next day after the operation.
After childbirth, the drug can be prescribed only to women who are not breastfeeding; you should start taking a contraceptive no earlier than the 1st day of menstruation. During lactation, the use of the drug is contraindicated.

The missed tablet must be taken within the next 12 hours. A decrease in the contraceptive effect is observed in cases where the interval between pills was more than 36 hours. To avoid the appearance of intermenstrual spotting, Rigevidon should be continued from the already started package, excluding the missed tablet(s). In these cases, the use of additional, non-hormonal methods of contraception (for example, barrier) is recommended.

Contraindications

You can not use the drug in such cases:

herpes and / or severe itching of pregnant women;
vaginal bleeding of unknown origin;
age over 40;
pregnancy and lactation;
severe liver disease;
arterial hypertension in severe form;
endocrine diseases, including severe diabetes mellitus;
idiopathic jaundice of pregnant women in history;
malignant tumors (mainly endometrial cancer and breast cancer);
otosclerosis;
sickle cell anemia;
migraine;
cholecystitis;
familial forms of hyperlipidemia;
thromboembolism and the presence of a predisposition to their development;
liver tumors;
hemolytic anemia in a chronic course;
cystic skid;
congenital increase in serum bilirubin - hyperbilirubinemia (Gilbert, Dubin-Johnson, Rotor syndromes);
cerebrovascular and cardiovascular diseases in severe course (currently or with a burdened history);
hypersensitivity to the components of the drug.

Side effects

Usually this drug is well tolerated by patients, but sometimes side effects of Rigevidon occur, which develop transiently and disappear spontaneously.

For example, nausea, vomiting, headaches, weight gain and changes in libido, mood, manifestation of acyclic spotting, conjunctivitis, vision problems, and so on.

In rare cases, prolonged use of the drug causes chloasma, hearing loss, jaundice, generalized itching, convulsions, the frequency of epileptic seizures, hypertriglyceridemia, hyperglycemia, increased pressure, thrombosis or venous thromboembolism, skin rashes, changes in vaginal secretion, high fatigue, vaginal candidiasis, etc. .

In the following cases, Rigevidon should be discontinued:

The period three months before the planned pregnancy;
The onset of pregnancy;
Prolonged immobilization;
The appearance of early signs of phlebothrombosis or phlebitis;
Increase in epileptic seizures;
The occurrence of generalized itching;
The appearance of unusually severe headaches;
Cerebrovascular disorders;
A sharp increase in blood pressure;
The occurrence of jaundice or hepatitis without jaundice;
Suspicion of a heart attack or thrombosis;
A sharp deterioration in visual acuity;
The appearance or intensification of an existing migraine-like headache;
The appearance of stabbing pains of unknown origin when coughing or breathing, a feeling of tightness and pain in the chest;
Period 6 weeks before the planned operation.

The use of Rigevidon does not affect the ability to drive vehicles and work with potentially dangerous mechanisms.

Analogues

Structural analogues for the active substance:

Anteovin;
Microgynon;
minisiston;
Minisiston 20 fem;
Ovidon;
Oralcon;
Rigevidon 21+7;
Tri-regol;
Tri-regol 21+7;
Trigestrel;
Triquilar.

Attention: the use of analogues must be agreed with the attending physician.