Calcemin Advance: a drug for bone strength. Calcemin advance: instructions for use How much to take Calcemin

"Calcemin Advance" is a combined drug that regulates the exchange of phosphorus and calcium. This tool eliminates the deficiency of trace elements, calcium and magnesium, provides the body with vitamin D3. The action of the drug "Calcemin Advance" is described by doctors as an action aimed at improving the condition of bones and joints, which can significantly reduce the likelihood of developing diseases affecting the musculoskeletal system.

Composition and form of release "Calcemin Advance"

The tool is available in the form of tablets that have a shell. There may be 30, 60 or 120 pieces in a package. The tablets contain sodium carbonate and borate, vitamin D3. The preparation also contains copper and zinc in the form and manganese in the form of sulfate.

In the production of funds from excipients, microcrystalline cellulose, croscarmellose sodium is used. The components of the same action include maltodextrin. Additionally, soy polysaccharide, acacia, stearic acid are used.

The shell is formed from magnesium silicate, hypromellose, mineral oil, triacetin, dyes.

pharmachologic effect

The drug "Calcemin Advance" instructions for use, reviews are presented as a tool that inhibits bone resorption, helps to increase its density.

The tool successfully fights against the lack of vitamin D3 and calcium. It is used to mineralize teeth. The presence of the required amount of calcium ensures the normal regulation of neuromuscular conduction. This element is involved in the process of blood coagulation, vitamin D3 contributes to its better absorption after the drug enters the intestine. "Calcemin Advance", influencing the production of parathyroid hormone, keeps its amount normal. In this way, the increase in bone resorption is stopped.

Metabolism occurs in the liver, the metabolites formed as a result of this process are excreted by the kidneys.

Indications for use "Calcemin Advance"

With osteoporosis, take Calcemin Advance. Instructions, reviews show that the drug is prescribed both for complex treatment and for the prevention of this disease in the following cases:

  • menopause (surgical, natural);
  • long-term use of immunosuppressants, corticosteroids.

The use of vitamins is carried out in order to implement therapy for lesions of the musculoskeletal system, when the main task is to improve the consolidation of fractures resulting from traumatic exposure.

For adolescents, doctors prescribe this remedy, if necessary, to eliminate the deficiency of calcium and trace elements. For the same purpose, tablets are used for increased physical exertion.

childbearing, lactation

The attending physician decides whether a woman needs to use Calcemin Advance tablets. Feedback left after treatment with the drug often reports the need to take into account that vitamin D3 and metabolites that are formed as a result of metabolism may be present in breast milk. It is important to pay attention to how much this vitamin enters the body from other sources.

Kidney disorders

Tablets may worsen the condition of patients with renal insufficiency, which is moderate. In such cases, medical supervision is needed.

Contraindications to taking "Calcemin Advance"

In some cases, patients should not be prescribed Calcemin Advance. Instructions for use, reviews for such cases include:

  • hypersensitivity to components;
  • age less than 12 years;
  • the presence of kidney stones;
  • urinary excretion of large amounts of calcium;
  • a pathological condition in which there is an increased content of calcium in the blood plasma.

The use of vitamins

The drug is taken orally during meals. Patients are prescribed a double dose of the drug at a dosage corresponding to one tablet. The duration of the course of therapy is generally 1-1.5 months. It is set by the doctor separately for each case. The maximum dose at one time cannot exceed two tablets, the maximum daily dosage should not exceed three tablets. If necessary, the doctor will extend the treatment.

Side effects

After taking Calcemin Advance, a review of the drug may contain some information indicating the possibility of developing adverse reactions. Among the possible side effects are the occurrence of allergic reactions, the appearance of flatulence, vomiting and nausea preceding it. The presence of hypercalciuria or hypercalcemia may also be detected. Side effects are possible, but they are very rare.

Overdose, in addition to the above manifestations, is accompanied by constipation. Irreversible changes in the heart, blood vessels, kidneys are possible. In case of overdose, the drug is discontinued, gastric lavage is performed, and symptomatic treatment is carried out.

special instructions

When Calcemin Advance vitamins are used for therapy, reviews recommend taking the remedy strictly at the prescribed dose, since the intake of a large amount of calcium into the body can cause disturbances in the absorption processes in the gastrointestinal tract of zinc, iron, and other important substances.

Since there is some threat to the health of patients with renal insufficiency (moderately expressed), the doctor should regularly monitor the level of calcium in the blood plasma and in the urine.

To prevent an overdose due to an excess of vitamin D3, when planning treatment, all sources from which this substance enters the body should be taken into account.

During pregnancy, the dose corresponding to 600 IU (vitamin) and 1500 mg (calcium) should not be exceeded.

drug interaction

Regarding the drug interaction of Calcemin Advance, the review is not always positive. This indicates that an independent combination of drugs is incorrect, which means that you need to consult a doctor to find out the possibility of sharing "Calcemin Advance" with other means.

When vitamins are taken in conjunction with barbiturates or phenytoin, the activity of the complex may decrease. If sodium fluoride or bisphosphonates are used together, Calcemin Advance may impair their absorption. An interval of 2 hours (minimum) must be observed.

When taken simultaneously with cardiac glycosides, they can enhance their toxic and therapeutic effects. It is important to monitor the clinical condition of patients and regularly do an ECG.

In cases where calcium-based preparations and tetracyclines are used simultaneously, increased absorption of tetracyclines from the gastrointestinal tract is possible. If you need to use both tetracyclines and Calcemin Advance, the doctors' review allows this possibility. However, the funds must be used so that the interval between their doses is at least three hours.

GCS, laxatives with oils have a bad effect on the absorption of the drug, they slow down this process. Thiazide diuretics used during therapy with the complex increase the risk of hypercalcemia and increase calcium reabsorption. "Loop" diuretics increase the release of calcium into the urine.

Reviews, the price of "Calcemin Advance"

The cost is determined by the number of tablets in the package "Calcemin Advance". Price, reviews are of primary importance when buying a drug. For 30 tablets, you will have to pay from about 235 to 400 rubles, 60 tablets of the product can be purchased for 530-580 rubles. The cost of the drug, the package of which includes 120 tablets, is 590-775 rubles.

Judging by the reviews, the drug is often prescribed to strengthen hair and nails. People who used "Calcemin Advance" for hair loss, mostly write good reviews. For most of them, the drug helps to cope with this problem.

The remedy is prescribed to saturate the body with minerals. The advantage of the complex is an effective combination of macro- and microelements, vitamins. But not everyone likes the presence of additional components that can harm the body. Vitamins are useful for bones during menopause, when the body lacks calcium. They are often used during pregnancy to relieve joint and back pain, and as a source of calcium and vitamin D3. "Calcemin Advance" knowingly has so many positive reviews. The drug copes with all its tasks, side effects are rare phenomena. To take "Calcemin Advance", instructions for use, price, reviews are required to study. Taking pills is possible only after a doctor's prescription and in the dose recommended by him. Then the effect will be maximum, and side effects are unlikely to appear, since usually patients do not have them.

active substances: 1 tablet contains calcium (calcium carbonate, calcium citrate) 500 mg, vitamin D 3 (cholecalciferol) 200 IU, magnesium (magnesium oxide) 40 mg, zinc (zinc oxide) 7.5 mg, copper (copper oxide) 1 mg, manganese (manganese sulfate) 1.8 mg, boron (sodium borate) 250 mcg

Excipients: maltodextrin, microcrystalline cellulose, croscarmellose sodium, acacia, hypromellose, stearic acid, soy polysaccharide, titanium dioxide (E 171), sodium lauryl sulfate, magnesium silicate, triacetin, mineral oil, special red AC (E 129), sunset yellow FCF (E 110 ), brilliant blue FCF (E 133).

Dosage form

Coated tablets.

Pink, oval film-coated tablets with a notch on one side.

Name and location of the manufacturer

Contract Pharmacal Corporation, USA

135 Adams Avenue, Hopog, NY 11788, USA /

Pharmacological group

Calcium, combinations with vitamin D and/or other drugs. ATC code A12A X.

Calcium is an important structural component of bone tissue. The use of calcium corrects the deficiency of calcium intake from food, especially with increased demand or with reduced absorption.

Calcium carbonate is the salt with the highest content of elemental calcium. Calcium citrate increases the bioavailability of the drug in patients with low acidity of gastric contents, achlorhydria, while taking H2-histamine receptor blockers, reduces the risk of stone formation in the urinary tract with long-term use, has a high antiresorptive potential, due to inhibition of parathyroid hormone.

Vitamin D very important for the absorption of calcium, phosphate and magnesium in the small intestine. It regulates the content of these elements in body fluids and contributes to maintaining a normal level of calcium in the blood, and also participates in the synthesis of organic elements and calcification of the skeleton.

Magnesium participates in the metabolism of bone tissue, prevents demineralization of bones, inhibits the deposition of calcium in the walls of blood vessels, heart valves, muscles, urinary tract.

Zinc is a cofactor of more than 200 enzymes and affects the process of bone tissue remodeling.

Copper participates in the construction of the most important connective tissue proteins - collagen and elastin, which form the matrix of bone and cartilage tissue.

Manganese normalizes the synthesis of glycosaminoglycans necessary for the formation of bone and cartilage tissue. Duplicates the calcium-sparing functions of vitamin D.

Bor regulates the activity of parathyroid hormone and through it - the exchange of calcium, magnesium, phosphorus and cholecalciferol.

Indications

To slow down the rate of bone loss and correct calcium metabolism disorders, to treat diseases of the musculoskeletal system and diseases of the teeth. It is recommended for children over 12 years of age, adults, including women in peri- and postmenopause, especially if there are contraindications to the use of hormone replacement therapy. As part of the complex treatment of conditions accompanied by a significant loss of bone mass. As a basic agent when using anti-resorbents (hormone replacement therapy, calcitonin, bisphosphonates) and stimulants of bone tissue formation. Osteopenic condition, systemic osteoporosis and its complications.

Contraindications

Hypersensitivity to the components of the drug (allergic reactions) hypercalcemia and / or conditions leading to hypercalcemia (sarcoidosis, malignant neoplasms and primary hyperthyroidism), severe hypercalciuria, impaired renal function, nephrolithiasis; hypervitaminosis D

Appropriate safety precautions for use

An overdose of calcium and vitamin D is accompanied by side effects, including hypercalcemia and hypercalciuria. Calcium and vitamin D should be used with caution so as not to exceed the total dose of calcium of 2500 mg and 4000 IU of vitamin D, taking into account intake with food (see section "Overdose").

Patients who are taking other medicines containing vitamin D and/or calcium or any other medicines should consult their doctor before taking this medicine.

During long-term treatment with drugs containing calcium in combination with vitamin D, as well as in patients with mild or moderate renal insufficiency (including elderly patients), it is necessary to control the level of calcium, phosphate and creatinine in the blood serum; calcium and phosphate - in the urine. If there are signs of hypercalcemia, or impaired renal function, calciuria, which exceeds 7.5 mmol / day (300 mg / day), the dose should be reduced or the drug should be discontinued. Patients with impaired renal function and with the simultaneous use of cardiac glycosides, calcium channel blockers and / or thiazide diuretics, monitoring of the functional state of the kidneys should be carried out by determining the level of creatinine in the blood serum (see Section "Interaction with other drugs and other forms of interaction") .

Combined drugs should be used with caution in immobilized patients due to an increased risk of hypercalcemia.

Use during pregnancy or lactation

During pregnancy and lactation, the drug is used according to indications and under medical supervision. The use of the drug in recommended doses is considered safe. Recommended doses should not be exceeded as chronic overdose may be harmful to the fetus and newborn.

Hypercalcemia in a future mother during pregnancy due to the use of high doses of vitamin D can lead to the development of side effects in the fetus: inhibition of parathyroid hormone, hypocalcemia, tetany, epileptic seizures and aortic stenosis syndrome, the symptoms of which may be retinopathy, mental retardation or growth failure; and also lead to the development of hypercalcemia in newborns.

Vitamin D and calcium are excreted into breast milk. This should be considered if the child is receiving any appropriate supplements.

To date, there is no evidence suggesting a possible adverse effect of vitamin D and/or calcium on human fertility.

The ability to influence the reaction rate when driving vehicles or working with mechanisms. Does not affect.

Children

Not intended for use by children under 12 years of age.

Dosage and administration

Adults and children over 12 years of age take 1 tablet 1-2 times a day with meals. In case of significant loss of bone mass, the dose may be increased to 3 tablets per day. The course of treatment is determined by the doctor depending on the nature of the disease.

Overdose

Intake of calcium and vitamin D in doses exceeding 2500 mg of calcium and 4000 IU/day of vitamin D may lead to toxic effects.

In patients with hypercalcemia or conditions associated with hypercalcemia, renal insufficiency and / or a tendency to nephrolithiasis, toxic effects of calcium and vitamin D may occur at low doses.

Acute or prolonged overdose of calcium and vitamin D can cause hypervitaminosis D, hypercalcemia, hypercalciuria, and hyperphosphatemia. The consequences are renal failure, "milk-alkaline syndrome", calcification of blood vessels and soft tissues, including calcification, which leads to nephrolithiasis nephrocalcinosis.

Non-specific primary symptoms such as sudden onset of headache, muscle weakness, depression of consciousness and gastrointestinal disturbances (abdominal pain, constipation, diarrhea, nausea and vomiting) may indicate an acute overdose.

If such symptoms occur, stop using the drug and consult a doctor.

Laboratory and clinical manifestations of poisoning and hypercalcemia may include symptoms such as anorexia, weight loss, fatigue, thirst, polyuria, bone pain, cardiac arrhythmias, and impaired absorption of other minerals. A change in laboratory data may be an increase in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in plasma. Chronic overdose can cause calcification of vessels and organs as a result of hypercalcemia. Extremely high hypercalcemia can lead to coma and death.

Side effects

From the gastrointestinal tract. Gastrointestinal and abdominal pain, dyspepsia (including abdominal discomfort), constipation, diarrhea, flatulence, nausea and vomiting.

From the side of the immune system(allergic reactions, anaphylactic reactions, anaphylactic shock). Rarely, hypersensitivity reactions have been reported, accompanied by relevant laboratory and clinical manifestations, including asthma syndrome, mild to moderate reactions, affecting the skin and / or respiratory system, gastrointestinal tract and / or cardiovascular system. Symptoms may include rash, urticaria, edema, skin redness, itching, non-cardiogenic pulmonary edema. Very rarely, severe reactions, including anaphylactic shock, have been reported.

From laboratory data. With prolonged use in high doses, the development of hypercalcemia, hypercalciuria, hypervitaminosis D is possible.

Interaction with other medicinal products and other forms of interaction

When using this drug with other drugs, you should consult your doctor.

Interaction with other drugs.

Calcium may lead to reduced absorption of other drugs (including antibiotics (eg, tetracycline, quinolones) and antivirals, protease inhibitors, eltrombopag) from the gastrointestinal tract. At the same time, calcium absorption may also decrease. To prevent potential interactions, a break between the use of these drugs should be at least 2:00 before or 4-6 hours after calcium intake, unless otherwise indicated.

Levothyroxine should be taken at least 4:00 before or 4:00 after calcium intake. Phosphates, bisphosphonates, and fluorides should be taken at least 30 minutes before calcium intake, but better at other times or days. It is not recommended to take the drug simultaneously with antacids containing aluminum, due to a decrease in their effectiveness.

Calcium and/or vitamin D. Thiazide diuretics reduce urinary calcium excretion. - Due to the increased risk of hypercalcemia with the simultaneous use of thiazide diuretics, serum calcium levels should be checked regularly.

With simultaneous use with furosemide and other "loop" diuretics, calcium excretion by the kidneys increases.

Cardiac glycosides and calcium channel blockers: Hypercalcemia increases the risk of lethal arrhythmia with cardiac glycosides such as digoxin and reduces the effectiveness of calcium channel blockers such as verapamil in atrial fibrillation. It is recommended to monitor the level of calcium in the blood serum, ECG and the clinical condition of the patient. Glucocorticoids, hormonal contraceptives impair the absorption of calcium ions.

Vitamin D Some drugs may reduce the absorption of vitamin D from the gastrointestinal tract. To minimize interactions, these drugs and vitamin D should be used at least 2 hours before or 4-6 hours after vitamin D intake. These drugs are: ion exchange resins (eg, cholestyramine), laxatives, orlistat. Carbamazepine, phenytoin, or barbiturates increase the metabolism of vitamin D to its inactive metabolites and thus reduce its effect.

With the simultaneous use of Calcemin Advance with vitamin A, the toxicity of vitamin D 3 decreases.

Interaction of calcium with food and supplements. Oxalic acid, found in spinach and rhubarb, and phytic acid, found in whole grains, can inhibit calcium absorption. Therefore, it is not recommended to consume foods containing calcium within two hours after eating a meal rich in oxalic and phytic acid.

Active ingredients:

calcium (calcium citrate and calcium carbonate) 500 mg

vitamin D3 200 ME

magnesium (magnesium oxide) 40 mg

zinc (zinc oxide) 7.5 mg

copper (copper oxide) 1 mg

manganese (manganese sulfate) 1.8 mg

boron (sodium borate) 250 mcg

Excipients: microcrystalline cellulose (E460), stearic acid (E570), croscarmellose sodium, maltodextrin, soy polysaccharide, sodium lauryl sulfate. Shell: hypromellose, magnesium silicate (E553a), titanium dioxide (E171), triacetin (E1518), mineral oil (E905), FD&C Red No. 40 Lacquer (E129), FD&C Blue No. 1 Lacquer (E133), FD&C Yellow No. 6 Lacquer (E110).

Pharmacotherapeutic group

mineral supplements. Combinations of calcium with vitamin D and/or other agents. ATC code: A12AX.

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Pharmacological properties

Combined preparation containing vitamins, macro-/microelements. The action is due to the properties of the ingredients included in the composition.

Pharmacokinetics

Calcium is absorbed predominantly in the proximal small intestine via an active vitamin D-dependent transport mechanism. The calcium received after absorption is distributed among organs and systems and, first of all, enters the bone tissue.

In the stomach, calcium ions are released in a pH dependent manner. Absorption of calcium in the form of calcium carbonate is about 20-30% and occurs mainly in the duodenum through vitamin D-dependent, saturable, active transport. Excreted in urine, feces and sweat. Urinary calcium excretion is a function of glomerular filtration and tubular reabsorption of calcium.

Vitamin D is absorbed in the small intestine. Bioavailability is 50-70%. It binds to specific alpha globulins and is transported to the liver, where it is metabolized to 25-hydroxycholecalciferol. Subsequent hydroxylation to 1,25-dehydroxycholecalciferol occurs in the kidneys. This metabolite is responsible for the vitamin's ability to increase calcium absorption. Unmetabolized vitamin D is stored in adipose and muscle tissue. Vitamin D is excreted in feces and urine.

Minerals are absorbed mainly in the upper small intestine and excreted by the kidneys. In addition, they can be partially excreted in the feces.

Indications for use

Replenishment of calcium, vitamin D and micronutrient deficiencies when the need for them cannot be met by an appropriate diet, especially in case of long-term deficiency, irregular and unbalanced nutrition and increased needs, in particular at certain periods of life:

Adolescence post-menopause pregnancy and lactation (according to clinical indications and / or doctor's recommendation) older age,

For prevention and as an adjunct to specific therapy for osteoporosis.

Dosage and administration

Adults and adolescents over 12 years old: 1 tablet twice a day with meals.

Elderly patients:

without any special instructions.

Patients with impaired renal function:

contraindicated in patients with severe renal insufficiency. With impaired renal function of mild and moderate severity - with caution, under the control of the concentration of calcium and phosphorus in the blood and urine.

Patients with impaired liver function:

without any special instructions.

Durationtreatment:

When used to compensate for calcium and vitamin D deficiency, the average duration of treatment is at least 4-6 weeks.

When used for the prevention of osteoporosis, the average duration of the course is 2 months; in the treatment of osteoporosis - 3 months.

The number of repeated courses during the year is determined by the doctor.

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Side effects

From the gastrointestinal tract: in rare cases, constipation, bloating, abdominal pain, diarrhea, nausea, vomiting.

From the immune system: allergic and anaphylactic reactions, very rarely anaphylactic shock, hypersensitivity reactions, including asthmatic syndrome, mild and moderate skin reactions (rash, urticaria, swelling, itching) and / or respiratory system, gastrointestinal tract and / or cardiovascular system (symptoms may include respiratory distress syndrome).

After prolonged use of the drug, the level of calcium in the urine and the concentration of calcium in the blood serum may increase, which should be monitored by a doctor.

If you experience any of the listed adverse reactions, as well as a reaction not listed in the package insert, you should consult a doctor.

Contraindications

Increased individual sensitivity to any of the components of the drug.

Hypercalcemia, severe hypercalciuria, nephrolithiasis, hypervitaminosis D, severe renal failure.

Overdose

There is no evidence that the drug can lead to overdose when used in accordance with the recommendations for use.

Most, if not all, reports of overdose have been associated with the concomitant use of large doses of mono- and/or multivitamin preparations.

Intake of calcium and vitamin D in doses exceeding 2500 mg calcium and 4000 IU/day of vitamin D may lead to toxic effects.

In patients with hypercalcemia or conditions associated with hypercalcemia, renal insufficiency and / or a tendency to nephrolithiasis, toxic effects of calcium and vitamin D may occur at lower doses.

Patients with impaired renal function are at increased risk of hyperphosphatemia, nephrolithiasis, and nephrocalcinosis.

Acute or prolonged overdose of calcium and vitamin D, especially in predisposed patients, can cause hypervitaminosis D, hypercalcemia, hypercalciuria, and hyperphosphatemia. Consequences include renal failure, "milk-alkali syndrome", vascular and soft tissue calcification, including calcification leading to nephrolithiasis.

Signs of acute overdose may include sudden headache, confusion, and gastrointestinal disturbances such as constipation, diarrhea, nausea, and vomiting. If these symptoms appear, treatment should be discontinued and a doctor should be consulted.

Laboratory and clinical manifestations of toxicity and hypercalcemia are varied and depend on the susceptibility of the patient and the accompanying circumstances. Symptoms may include anorexia, weight loss, thirst, polyuria, and malabsorption of other minerals. Changes in laboratory parameters are possible: an increase in the concentration of aspartate aminotransferase and alanine aminotransferase in blood plasma. Chronic overdose can lead to calcification of vessels and organs caused by hypercalcemia. Extremely high hypercalcemia can cause coma and death.

Treatment: rehydration, the use of loop diuretics (eg, furosemide), glucocorticosteroids, calcitonin, bisphosphonates, in severe cases, hemodialysis.

Precautionary measures

Do not exceed the recommended dose. Calcemin Advance should be taken under close medical supervision when other sources of high doses of vitamin D and/or medicinal products or nutrients (such as milk) containing calcium are co-administered. In this case, regular monitoring of the calcium content in the blood serum and urine is required.

During long-term treatment with combined calcium and vitamin D preparations, it is necessary to monitor serum and urinary calcium levels, as well as kidney function by measuring serum creatinine, especially in elderly patients, and with concomitant therapy with cardiac glycosides, calcium channel blockers and / or thiazide diuretics. This also applies to patients with a high tendency to form stones. In case of hypercalcemia or signs of impaired renal function, reduce the dose or discontinue treatment.

Vitamin D is recommended to be used with caution in patients with mild to moderate renal impairment and under the control of calcium and phosphate in the blood serum. Be aware of the risk of soft tissue calcification. In patients with severe renal insufficiency, vitamin D in the form of cholecalciferol is not metabolized. Therefore, other forms of vitamin D are recommended in these patients.

Due to the risk of increased metabolism of vitamin D to its active form, the drug should be used with caution in patients with sarcoidosis. In these patients, it is recommended to monitor the calcium content in the blood serum and urine.

The drug is not intended for use in children under 12 years of age.

Combined vitamin preparations should be used with caution in immobilized (immobilized) patients with osteoporosis due to an increased risk of hypercalcemia.

It is obligatory to consult a doctor regarding the use of the drug in diseases of the kidneys, urolithiasis, diseases of the parathyroid glands, metastases of tumors in the bones.

Interaction with other drugs

Phenytoin, barbiturates,carbamazepine, rifampicin: may reduce the effect of vitamin D3 by increasing its metabolism to inactive metabolites.

Bisphosphonates, fluorides: may reduce the absorption of bisphosphonates and sodium fluoride in the gastrointestinal tract. It is recommended to take at least 1-2 hours before or after taking Calcemin Advance. Preferably, bisphosphonates and calcium preparations are used at different times of the day.

Tetracycline: may reduce the absorption of tetracycline in the gastrointestinal tract. It is recommended to take at least 2-3 hours before or 4-6 hours after taking Calcemin Advance.

Cardiac glycosides, calcium channel blockers: possible increase in the toxicity of cardiac glycosides (danger of lethal arrhythmias). It is recommended to monitor the ECG and the concentration of calcium in the blood. The effectiveness of calcium channel blockers, such as verapamil, is reduced in atrial fibrillation. Co-administration is not recommended.

Levothyroxine: possible violation of the absorption of levothyroxine. Recommended to be taken at least 2-4 hours before or 4-6 hours after taking this drug.

Quinolones, antiviral agents: possible violation of the absorption of antibacterial agents from the group of quinolones (for example, ciprofloxacin, levofloxacin, norfloxacin, ofloxacin, nalidixic acid) and antiviral agents (protease inhibitors). Recommended to be taken at least 2-4 hours before or 4-6 hours after taking this drug.

Thiazide diuretics: thiazide diuretics reduce urinary calcium excretion. Due to the increased risk of hypercalcemia with the simultaneous use of thiazide diuretics and calcium preparations, it is recommended to regularly check the level of calcium in the blood serum in case of long-term treatment.

Glucocorticoids, hormonal contraceptives: reduce calcium absorption, possibly reducing the effect of vitamin D3. Dose adjustment of Calcemin Advance may be required.

Magnesium is rapidly absorbed from the gastrointestinal tract. Over 90% of magnesium is excreted in the bile into the intestine and later in the feces, the rest is excreted by the kidneys in the form of water-soluble compounds.
Zinc is absorbed in the intestines, excreted in feces (90%) and urine (2-10%).
Copper is partially absorbed in the small intestine. The remainder is excreted in the feces as insoluble compounds. Of the total amount of absorbed copper, about 80% is excreted in the bile, 16% in the walls of the gastrointestinal tract and 4% in the urine. A small amount of this element is excreted with sweat.
Boron is rapidly absorbed in the gastrointestinal tract, excreted mainly (up to 90%) in the urine.

Indications for use of the drug Calcemin advance

Comprehensive treatment of osteoporosis of various origins and its complications (fractures, etc.), as well as dental and periodontal diseases. It is recommended as basic therapy when using anti-resorbents (hormone replacement therapy, calcitonin, bisphosphonates) and bone tissue formation stimulants. To reduce the risk of fractures with a deficiency of calcium, vitamin D3, minerals in the diet.

Application of the drug Calcemin advance

Adults and children over 12 years of age - 1 tablet 1-2 times a day with meals. In case of significant loss of bone mass, the dose may be increased to 2 tablets 1-2 times a day.

Contraindications to the use of the drug Calcemin advance

Increased individual sensitivity to any of the components of the drug (allergic reactions).

Side effects of Calcemin Advance

In rare cases, a feeling of moderate nausea, bloating, constipation or diarrhea; in isolated cases - allergic reactions.

Special instructions for the use of the drug Calcemin advance

During pregnancy and lactation, take no more than 2 tablets per day.

Interactions with Calcemin Advance

Overdose of the drug Calcemin advance, symptoms and treatment

For the drug Calcemin Advance is not described. In case of an overdose, symptomatic treatment is recommended - gastric lavage, plenty of fluids, a diet low in calcium.

Storage conditions of the drug Calcemin advance

At room temperature in a dry dark place.

List of pharmacies where you can buy Calcemin advance:

  • Saint Petersburg

Calcemin Advance is a complex drug that helps to adjust the level of phosphorus-calcium metabolism in blood plasma. The medicine is prescribed for adults and children for the complex treatment and prevention of diseases of the musculoskeletal system. Instructions for use Calcemin Advance will allow you to get acquainted in detail with the pharmacological action of the drug.

Calcemin Advance is a combined preparation that contains micro and macro elements, vitamins; pharmacological action is due to the properties of the components that make up its composition:

  • Calcium increases the density and resection of bone tissue, participates in its formation, reduces resorption, strengthens joints and bone tissue. Calcium citrate normalizes the absorption of calcium, regardless of the state of the gastrointestinal tract, which allows the drug to be taken by patients with reduced secretory function of the gastrointestinal tract; reduces the level of bone tissue markers, which indicates a slowdown in the processes of its destruction; regulates the content of calcium, respectively, prevents the formation of kidney stones; promotes the absorption of iron, thereby significantly reducing the risk of developing IDA, regulates the content of parathyroid hormone in the blood, which improves the regulation of calcium homeostasis.
  • Colecalciferol (vitamin D 3) regulates and replenishes the exchange of calcium and phosphorus, effectively affects the strengthening of bone structure, affects the reabsorption of phosphorus in the renal channels and the absorption of calcium in the intestines.
  • Zinc helps to strengthen bone tissue and has a positive effect on the synthesis of sex hormones.
  • Magnesium contributes to the formation of muscle and bone tissue. Magnesium and zinc are necessary for the human body for the process of synthesizing organic bone matrix.
  • Copper regulates the process of collagen synthesis, having a positive effect on the formation of bone mass.
  • Manganese forms the matrix of bone tissue, participates in the formation of proteoglycans, thereby improving the strength of bone tissue.
  • Boron improves calcium absorption, reduces the activity of parathyroid hormone, reduces the risk of developing cholecalciferol deficiency, and prevents the development of osteoporosis.

Release form

Dosage form: tablets.

Tablet color: pink.

Shape: biconvex, oval, risk on one side.

Packing type: polyethylene bottle, each packed in a carton box.

The drug is available in 3 dosages: 30, 60, 120 pcs. in every vial.

The composition of the drug

Active substances in one tablet:

  • calcium (calcium carbonate, calcium tetrahydrate);
  • cholecalciferol (vitamin D 3);
  • magnesium (magnesium oxide);
  • zinc (zinc oxide);
  • copper (copper oxide);
  • manganese (manganese sulfate);
  • boron (sodium borate decahydrate).

Excipients:

  • core: maltodextrin, sodium lauryl sulfate, soy polysaccharide, stearic acid, croscarmellose sodium, microcrystalline cellulose;
  • shell: mineral oil, hypromellose, titanium dioxide, triacetin, magnesium silicate, aluminum varnish (Red No. 40) - 0.315 mg; aluminum varnish (Yellow No. 6) - 0.078 mg, aluminum varnish (Blue No. 1) - 0.05 mg.

Instructions for use

Calcemin Advance has several indications for use. His doctors prescribe for the complex treatment of diseases of the musculoskeletal system and for preventive purposes.

The medicine does not relieve the inflammatory process, pain, does not have an antimicrobial effect, does not help with temperature, it has a different mechanism of action - it provides the body with the necessary trace elements and vitamins.

  • therapy and prevention of osteoporosis;
  • treatment of many diseases of the musculoskeletal system;
  • improved consolidation of fractures and injuries;
  • long-term use of immunosuppressants;
  • treatment of bone resorption;
  • period of menopause;
  • lack of calcium;
  • preventive measures in dentistry;
  • replenishment of trace elements and minerals in a period of increased need (development of the musculoskeletal system, fractures, pregnancy, lactation).

Before you start taking the drug, you need to consult a specialist.

Calcemin Advance for children

Indications for the use of medicine for children:

  • deficiency of vitamins and microelements;
  • diseases of the musculoskeletal system;
  • injuries, fractures, etc.

The dosage of the drug is determined by the specialist after a comprehensive examination.

Pregnancy and lactation

During pregnancy or lactation, Calcemin Advance can only be taken as directed by a doctor. It is forbidden to exceed the dosage of the drug prescribed for this period, since an excess of calcium in the body of a pregnant woman negatively affects the development of the fetus - it leads to hypercalcemia, aortic stenosis syndrome, and epilepsy. Also, the fetus may experience developmental delay and lack of growth.

When breastfeeding, it should be borne in mind that the components of the drug enter the child's body, so it is recommended to take the drug under the supervision of a specialist.

drug interaction

Calcemin Advance can reduce the effectiveness of certain drugs: antibiotics, antivirals, fluorides, phosphates, diuretics, antacids, while reducing the amount of absorbed calcium. With the simultaneous use of several drugs, including Calcemin Advance, you need to notify the doctor about this.

Also, due to the use of orlistan, ion exchange salts and laxatives, the absorption of vitamin D3 can be significantly reduced. Between their receptions it is recommended to take a break of several hours. Phenytoin, carbamazepine, barbiturates, vitamin A can interfere with the absorption of vitamin D3.

Contraindications

This complex drug has some contraindications. Before buying it, be sure to read the instructions. The medicine Calcemin Advance has absolute and relative contraindications.

Absolute contraindications include:

  • vitamin D hypervitaminosis;
  • hypercalciuria;
  • hypercalcemia;
  • renal failure in a severe anamnesis;
  • sarcoidosis;
  • tuberculosis;
  • intolerance to the components of the drug;
  • age up to 12 years;
  • urolithiasis disease;
  • allergy to peanut butter, soy.

Relative contraindications (conditions / diseases in the presence of which the prescription of the drug requires caution and specialist supervision):

  • pregnancy and lactation;
  • kidney failure.

Dosage

The dosage of Calcemin Advance depends on the etiology of the disease. A complex remedy is taken during a meal. Before taking the drug, you should read the annotation, which recommends the Calcemin Advance regimen:

  • osteoporosis (prevention): 1 tab. - once a day, application - 2 months;
  • osteoporosis (as part of complex treatment): 2 times a day - 1 table, duration - 3 months;
  • replenishment of calcium deficiency, improvement of consolidation of traumatic fractures: once a day, 1 tab., application - 2 months.

Side effects

Most often, Calcemin Advance has no side effects, but with individual intolerance to the components, sensitivity or prolonged use of the drug, some side effects may develop:

  • headache;
  • allergic reactions - redness, rashes, urticaria, dry skin;
  • on the part of the digestive tract - increased gas formation, abdominal pain, nausea, lack of appetite, a feeling of heaviness in the stomach;
  • changes in blood and urine tests - hypercalciuria and hypercalcemia.

Price

Calcemin Advance tablets are sold in dosages - 30, 60, 120 pcs. packaged. If the treatment is several months, the manufacturer offers significant savings when buying 60 or 120 tablets. packaged. This complex drug can be purchased at the pharmacy network, in the online store and ordered from the catalog.

The cost of Calcemin Advance in network pharmacies (average prices):

Analogues

Calcemin Advance has no structural analogues for the main active substance. However, there are many similar medicines based on vitamins and microelements on the pharmaceutical market.

  • Vitrum Osteomag (tablets). Manufacturer: Unipharm Inc (USA). The drug has differences in composition, but is used when the same problems occur as Calcemin Advance: osteoporosis, calcium deficiency, vitamin D3, for therapeutic and prophylactic purposes. Contraindicated at the age of up to 12 years and with increased sensitivity of the body to the components of the drug. Produced in the form of tablets: the price is from 378 rubles.
  • Calcium-D3 Nycomed (chewable tablets). Manufacturer: Nycomed Pharma AS (Norway). Contains a voluminous list of contraindications, as well as age restrictions. The drug is based on calcium, produced in the form of chewable tablets: 30 pcs., Price from 221 rubles.

Cheap analogues of Calcemin Advance:

Complivit calcium D3 (chewable tablets). Manufacturer: Pharmstandard-UfaVITA (Russia). The drug is in the same pharmacological group as Calcemin Advance, however, it contains only two active ingredients. Indications for use contain the same items. Sold in the form of chewable tablets: 30 pieces, price from 138 rubles.

Overdose

An overdose of the drug can lead to hypervitaminosis, hypercalciuria, hypercalcemia.

Symptoms of drug overdose: loss of appetite, headache, dizziness, thirst, polyuria, nausea, vomiting, constipation, fatigue, muscle weakness, bone pain, fainting, coma, mental disorders, urolithiasis, rarely - cardiac arrhythmias.

Long-term use of calcium can provoke soft tissue calcification, inflammation of the kidneys.

Overdose treatment. If signs of an overdose are found, the dose should be reduced immediately or the drug should be discontinued. If an overdose is caused by accidental circumstances, induce vomiting and gastric lavage. In special cases, symptomatic therapy is carried out.

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