Nazarel - complete instructions. Nazarel - instructions for use What actions does Nazarel have

Today, pharmacy shelves offer the widest range of drugs for the treatment of seasonal or year-round allergic rhinitis. One of these medicines is Nazarel - nasal drops, which have a convenient spray form for use.

drops nazarel

The drug (corticosteroid) is a white or almost white opaque homogeneous suspension, which is placed in dark glass vials. Each of them has equipment in the form of a dosing device and a protective cap. The bottles are packed in cardboard boxes with the obligatory application of instructions for use.

Nazarel spray

Nasal drops Nazarel are used exclusively in the form of a spray, which is quite convenient for the patient and allows you to accurately dose it, since when you press the sprayer once, only one dose of the drug is injected.

Nazarel testimony

The drug is indicated for use in the prevention and treatment of seasonal and year-round allergic rhinitis.

Nazarel contraindications

The drug Nazarel is contraindicated for use in children under the age of four, as well as if the patient has sensitivity to any components of the drug.

• Associated herpes;
• Bacterial infections of the upper respiratory system;
• Ulcerative lesions of the nasal mucosa;
• Post-traumatic or postoperative condition of the nasal cavity;
• Simultaneous use with other corticosteroids in the form of tablets, creams, ointments, agents for the treatment of bronchial asthma, as well as similar nasal or eye sprays and nasal drops;

Nazarel application

The drug is intended for intranasal use.

For adults and adolescents over the age of twelve, it is recommended to prescribe in each of the nasal passages a double dose (50 + 50 micrograms) once a day, preferably in the morning. In individual cases, a two-time administration during the day is allowed, where the maximum dose of the drug can be no more than 400 micrograms.

Upon reaching the desired effect from a therapeutic point of view, it is advisable to use 50 micrograms per day in each of the nasal passages as a maintenance dose.

For children from four to twelve years of age, the drug can be prescribed once a day for a single dose (50 micrograms) in each of the nasal passages - in the morning.

For pediatric patients, the size of the maximum daily dose should not exceed 200 micrograms in each nostril. Use the drug until the symptoms are eliminated.

To achieve a stable therapeutic effect, regular use of the drug is recommended.

Nazarel during pregnancy

Nazarel is not recommended for pregnant women. The possibility of its use can be allowed only in extreme cases, when the intended benefit to the mother will outweigh the potential risk to the fetus.

There is no evidence that the active substance of the drug fluticasone propionate can be excreted in breast milk, but if necessary, taking the drug during lactation, breastfeeding should be suspended.

Rules for the use of the drug

For the first use of the drug, the preparation of the vial is required, for which it is necessary to perform action in the form of pressing six times on the dispenser. The same should be done if the drug has not been used for more than a week. As a result of such manipulations, the spraying mechanism will be unlocked.

For the correct use of the spray, the following is necessary:

• Cleanse the nasal cavity;
• Close one of the nasal passages and insert the upper part of the dispenser into the other of them;
• Holding the bottle vertically, tilt your head slightly forward;
• While inhaling through the nose, press the dispenser once;
• Exhale through the mouth;
• Perform the same steps for the other nasal passage;

Opened packaging can be used until the expiration date of the drug.

Nazarel analogues

Analogues of Nazarel, that is, medications similar to him in terms of indications for use and pharmacology, can also be purchased at any pharmacy, but each of them, like Nazarel, is dispensed as prescribed by a doctor.

• Primalan (tablet form)
• Allergo-norm (in the form of tablets)
• Cromoglin (as a nasal spray)
• Rupafin (in tablet form)
• Atomer Propolis (as nasal spray)

Nazarel price

The drug Nazarel can be purchased at any pharmacy with a doctor's prescription. Its cost fluctuates around three hundred rubles.

Nazarel: instructions for use and reviews

Nazarel is a pharmacological drug in the form of a nasal dosed spray used in the treatment of allergic rhinitis. The medication belongs to the prescription range. The drug is characterized by a pronounced anti-allergic and anti-inflammatory effect, which appear 2 or 4 hours after the first use. There is a significant reduction in itching, sneezing stops.

Dosage form

The dosage form of Nazarel is presented as a nasal metered spray. Produced in glass bottles of various capacities, designed for 60, 120 or 150 doses. The bottle is sold in cardboard packs, instructions must be attached.

Description and composition

Nazarel is the trade name for a pharmacological agent based on fluticasone. Also, the following auxiliary components are included in the drug:

• phenylethanol;
• dextrose;
• polysorbate;
• benzalkonium chloride solution.

Nasal dosed spray belongs to the category of hormonal preparations based on synthetic hormones.

Pharmacological group

Nazarel is applied topically and belongs to the category of glucocorticoids, otherwise - GCS. When using the spray in the doses prescribed by the attending physician, there is a pronounced anti-inflammatory, anti-allergic and anti-edematous effects. The anti-inflammatory effect of the pharmacological agent is determined by the properties of fluticasone on glucocorticoid receptors. In the course of the progression of allergies, including at the early and late stages, due to the effect of the drug, the proliferation of the following structures is inhibited:

• neutrophils;
• mast cells;
• lymphocytes;
• macrophages;
• eosinophils;
• decrease in the synthesis and release of inflammatory mediators;
• decreased production of leukotrienes;
• decreased synthesis of prostaglandins;
• decrease in the production of histamine;
• the intensity of the formation of cytokines decreases.

The anti-allergic effect of fluticasone is observed after 2-4 hours from the moment of the first application and is manifested by a decrease in the intensity of rhinitis, sneezing, nasal congestion, nasal itching, pressure in the nose and eyes, and a decrease in eye manifestations associated with allergic rhinitis.

Indications for use

Nasal dosed spray Nazarel can be prescribed by the attending physician for the prevention and treatment of seasonal as well as year-round rhinitis, which is provoked by allergens.

for adults

The drug is an effective anti-allergic agent and is often prescribed to patients with allergic rhinitis. Self-administration or changing the dosage prescribed by the attending specialist is prohibited.

for kids

In pediatric practice, the drug is not used to treat patients of a younger age group. If indicated, Nazarel can be prescribed to children whose age is at least 4 years.

When carrying a fetus or during lactation, the use of a nasal dosed spray Nazarel is undesirable, since it belongs to the category of hormonal drugs. The drug can have an unpredictable effect on the developing fetus or breastfeeding child.

Contraindications

The nasal metered spray Nazarl has a number of absolute contraindications, which are as follows:

1. The medication is absolutely contraindicated in children whose age has not reached 4 years.
2. The use of a nasal spray is prohibited for patients who have personal hypersensitivity to fluticasone or auxiliary components of the drug.

Relative contraindications, in the presence of which the use of the drug is required with increased caution, are the following:

1. • herpes in the active phase;
   • period of gestation;
   • breastfeeding period;
   • ulcerative lesions of the nasal mucosa;
   • nose injury.

Also, caution is required when using Nazarel in the following situations:

1. Infectious lesions of the respiratory tract of bacterial origin. In this embodiment, additional use of antibiotic and/or antiviral drugs is required.
2. Surgical interventions in the structures of the nasal cavity, as well as the postoperative period after them.
3. Concurrent therapy with other glucocorticoid medications, including tablets, sprays, ointments, nasal drops, creams and anti-asthma inhalers.

Applications and doses

The drug Nazarel is intended exclusively for intranasal administration, that is, through the nasal cavity. In order to achieve the greatest therapeutic effect, regular use of a metered spray is required.

for adults

Patients of the adult age group are prescribed a single application of a spray at a dose of 100 mcg, which equals 2 clicks in each nasal passage. It is advisable to use the medication in the morning. In some cases, it may be necessary to use the recommended dose twice a day - in the morning and in the evening. When the desired therapeutic effect is achieved, it is possible to transfer the patient to the use of a maintenance daily dose, which is 50 μg administered in each nasal passage. The highest dosage per day is 400mcg of fluticasone, that is, 4 spray doses in each nasal passage. Elderly patients do not require dosage adjustment.

for kids

In the pediatric age group of patients from 4 to 12 years old, the recommended daily dose is 50mcg, that is, 1 click on the spray, into each nasal canal. It is advisable to use the medicine in the morning. The highest allowable spray dosage for children aged 4 to 12 years is 200mcg of fluticasone in each nasal canal. For children over 12 years of age, the spray is prescribed according to adult dosages. At the same time, it is required to take into account that it is desirable to use in pediatrics those dosages of nasal glucocorticoids that are the minimum necessary to achieve the desired therapeutic effect.

for pregnant women and during lactation

Use during the period of bearing a child and breastfeeding should be strictly agreed with the attending physician. The use of a metered-dose nasal spray during pregnancy is allowed only when the potential benefit to the mother outweighs the likely harm to the fetus. During lactation, it is desirable to refuse breastfeeding, since glucocorticoids can unpredictably affect the developing body of an infant.

Side effects

During the use of a nasal metered spray, relatively frequent side effects are:

• violation of taste perception;
• smell disorders;
• nosebleeds;
• dryness of the mucous membranes of the nasal cavity or irritation;
• soreness of the head.

Rarely, due to the use of Nazarel, the following conditions are able to develop:

• bronchospasm;
• anaphylactic conditions;
• delay in the development of the child;
• increase in fundus pressure;
• manifestations of skin hypersensitivity;
• decrease in the efficiency of the adrenal cortex;
• the occurrence of cataracts or glaucoma;
• perforation of the nasal septum;
• angioedema;
• development of osteoporosis;
• ulceration of the mucous membranes of the nose.

Interaction with other drugs

Due to the low plasma concentrations of fluticasone, its influence and interaction with other pharmacological drugs is unlikely. The parallel use of drugs based on fluthiazone with drugs that are potent inhibitors of the CYP3A4 isoenzyme, for example, Ritonavir, can lead to an increase in its systemic effects and, as a result, the progression of negative side effects, including inhibition of the adrenal cortex and provoking Cushing's syndrome.

The combination of fluticasone-based drugs with other inhibitors of cytochrome P450, for example, Ketonazrol, can lead to a slight increase in its content in the blood serum, but does not actually affect the concentration of cortisol.

special instructions

With a single appointment of Nazarel with inhibitors of the CYP3A4 isoenzyme, it is necessary to carefully monitor the patient's condition, since this combination can lead to an increase in fluticasone plasma values.

With prolonged use of high doses of intranasal glucocorticoids, there is a risk of systemic exposure, which requires constant monitoring of the functioning of the adrenal cortex.

Due to the likelihood of slowing the growth of the child, the use of glucocorticoids in pediatrics should be accompanied by regular monitoring of growth and timely dose adjustment.

Treatment of seasonal allergic rhinitis with Nazarel is effective, but high concentrations of allergens require the use of additional funds.

If it is necessary to use a dosed nasal spray in patients with herpetic keratitis, tuberculosis, an infectious process, and people who have recently undergone surgery on the nasal or oral cavity, it is necessary to take a balanced approach to treatment and evaluate the possible benefits and likely risks.

Overdose

Negative symptoms of acute and chronic overdose of fluticasone have not been recorded. In studies on volunteers and seven-day excess dosages, no effect on the hypothalamic-pituitary-adrenal system was found.

Storage conditions

The medication must be stored at a temperature not exceeding 25 ̊С, out of the reach of children. Shelf life is represented by 36 months.

Analogues

Analogues of Nazarel are represented by other pharmacological preparations for intranasal use. It is not recommended to independently replace the prescribed drug with an analogue.

Provides anti-allergic, anti-inflammatory. Anti-asthmic, anti-edematous and anti-exudative effects. It is forbidden to apply to children until they reach the age of 12. The active ingredient of the drug is presented. The drug belongs to glucocorticoids.

Price

The cost of Nazarel is an average of 375 rubles. Prices range from 270 to 482 rubles.

Nazarel- a preparation with fluticasone propionate for topical use. The active substance in its chemical structure is a glucocorticosteroid. When exposed to the nasal mucosa, fluticasone propionate binds to GCS receptors. As a result of exposure to receptors, the reproduction and development of cells responsible for the occurrence of an allergic reaction and, as a result, for the inflammatory process as a whole (mast cells, lymphocytes, eosinophils, macrophages, neutrophils) is suppressed. In addition, the active ingredients inhibit the release of inflammatory mediators during hypersensitivity reactions: histamine, prostaglandins, cytokines, leukotrienes. The drug reduces vascular permeability and reduces mucosal edema. Nazarel eliminates inflammation of the mucous membrane, eliminates edema, and has an anti-allergic effect. After injection of the drug, sneezing decreases, the intensity of itching in the nose decreases, it relieves the unpleasant sensation of pressure in the nasal sinuses and eyes, i.e. all symptoms of rhinitis are eliminated. Systemic action when used at doses indicated as therapeutic, is not observed. The effect on the hypothalamus-pituitary-adrenal system is minimal. The action of the drug is prolonged and lasts up to 24 hours.

Indications for use

Mode of application

Side effects

Contraindications

Pregnancy

Interaction with other drugs

Overdose

Storage conditions

Release form

Compound

Additionally

main parameters

Nazarel is a drug for the treatment of allergic rhinitis. The medicine is available in vials with a dispenser and is used for intranasal irrigation of the mucous membrane of the nasal concha.

It is used for allergic rhinitis, when a person is concerned about congestion and discharge of wear, tearing, sneezing and other symptoms of hypersensitivity.

In this article, we will look at why doctors prescribe Nazarel, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Nazarel can be read in the comments.

Composition and form of release

The drug is produced in the form of a dosed nasal spray having a white opaque color and a homogeneous structure.

• 1 dose of the drug contains 50 micrograms of the active compound in the form of fluticasone propinate.

Clinical and pharmacological group: GCS for intranasal use.

Indications for use

The drug Nazarel is prescribed for:

• treatment of seasonal rhinitis of allergic origin;
• prevention of allergic rhinitis;
• treatment of year-round rhinitis of allergic origin;
• prevention of perennial allergic rhinitis.

pharmachologic effect

The suppression of the inflammatory process is explained by the effect of the drug on the receptors. As a result of taking the drug, the proliferation process in mast cells, lymphocytes, neutrophils, eosinophils and macrophages is suppressed. The production and release of inflammatory mediators and other active compounds (cytokines, leukotreins, prostaglandins, histamines) also decreases during the late and early phases of allergic manifestations.

When used in therapeutic doses of fluticasone, propionate does not show a systemic effect and has practically no effect on the hypothalamic-pituitary-adrenal system.

The effect of the drug persists for 24 hours after a single application.

Instructions for use

According to the instructions for use, Nazarel is intended for intranasal use. For the correct use of the spray, the following is necessary:

1. Cleanse the nasal cavity;
2. Close one of the nasal passages and insert the upper part of the dispenser into the other of them;
3. Holding the bottle vertically, tilt your head slightly forward;
4. While inhaling through the nose, press the dispenser once;
5. Exhale through the mouth;
6. Perform the same steps for the other nasal passage.

Average spray dosing regimen:

• Adults and children 12 years of age and older are prescribed 2 doses (100 mcg) in each nasal passage 1 time / day, preferably in the morning. In some cases, it is necessary to inject 2 doses into each nasal passage 2 times / day (the maximum daily dose is 400 mcg). After achieving a therapeutic effect, you can enter a maintenance dose of 50 mcg / day in each nasal passage (100 mcg). The maximum daily dose should not exceed 400 mcg (4 doses in each nasal passage).
• Children aged 4 to 12 years are prescribed 1 dose (50 mcg) 1 time / day in each nasal passage, preferably in the morning. The maximum daily dose should not exceed 200 mcg in each nasal passage. It is necessary to use the minimum dosage that provides effective elimination of symptoms.

To achieve a stable therapeutic effect, regular use of the drug is recommended.

Contraindications

You can not use the drug in such cases:

1. Pregnancy and lactation;
2. Use in patients under 4 years of age;
3. Hypersensitivity or individual intolerance to Nazarel or its components.

Apply with caution:

1. Manifestations of the nasal mucosa;
2. Transferred surgical interventions on the nasal cavity;
3. Simultaneous use of GCS;
4. Concomitant bacterial or herpetic infection of the respiratory system.

Side effects

Spray Nazarel, according to the manufacturer's instructions, can have a negative impact on the individual characteristics of the body, as well as non-compliance with the dosage and the presence of contraindications for use.

From the side of the central nervous system, one can often observe:

• headache;
• smell disorders;
• taste disorders.

From the side of the visual analyzer, patients rarely note:

• increase in intraocular pressure;
• glaucoma;
• the occurrence of cataracts.

From the side of the immune system, the following manifestations are extremely rare:

• development of bronchospasm;
• anaphylactic shock;
• angioedema;
• dermatological manifestations of hypersensitization of the body.

From the side of the respiratory system:

• often patients indicate nosebleeds that appear after using the spray;
• sometimes there is dryness in the nose and a decrease in the secretion of mucous glands;

In exceptional situations, it is possible to perforate the nasal septum with a strong injection of the drug, as well as with careless handling of the bottle tip.

Nazarel's analogs

Structural analogues for the active substance:

• Cutiwait;
• Flixonase;
• Flixotide;
• Fluticasone;
• Fluticasone propionate.

Attention: the use of analogues must be agreed with the attending physician.