Medicinal reference book geotar. Where iodine is contained, features of its use What is the name of the preparation of an aqueous solution of iodine

Iodine is a drug that has an antiseptic, locally irritating and anti-inflammatory effect.

Release form and composition

Iodine is available in the form of 2% and 5% alcohol solution (in dark glass bottles of 10, 15, 25 or 100 ml; 5% iodine solution, in addition, in 1 ml ampoules, 10 ampoules per pack).

The active substance of the drug is iodine. In 1 ml of its solution contains 20 or 50 mg.

Excipients: 95% ethanol, potassium iodide.

Indications for use

Iodine is intended for external, topical and oral use.

Indications for external use: wounds, injuries, myalgia and infectious and inflammatory skin lesions.

Indications for local use: burns (infected, fresh thermal and chemical I-II degrees), wounds, varicose and trophic ulcers, purulent otitis media, atrophic rhinitis, chronic tonsillitis.

Indications for oral administration of Iodine: tertiary syphilis, atherosclerosis (including for prevention), chronic inflammation of the respiratory tract, chronic mercury and lead poisoning, hyperthyroidism, endemic goiter (including for prevention).

Contraindications

Contraindication for all methods of using Iodine is hypersensitivity.

Orally, in addition, the drug is not prescribed in the following cases:

Hemorrhagic diathesis;
Chronic pyoderma;
Acne;
Hives;
Furunculosis;
Adenomas, including the thyroid gland;
Jades;
Nephrosis;
Pulmonary tuberculosis;
Children's age up to 5 years;
Pregnancy.

Method of application and dosage

Externally, Iodine is used to treat damaged areas of the skin.

For oral administration, doses are set individually, taking into account the indications and the age of the patient. The solution is diluted in milk, taken after meals.

For the prevention of atherosclerosis, 1-10 drops are prescribed 1 or 2 times a day for 30 days, 2-3 such courses are carried out per year. For the treatment of atherosclerosis, as a rule, it is indicated to take 10-12 drops 3 times a day.

A single dose of iodine in tertiary syphilis can be from 5 to 50 drops, take the drug 2-3 times a day.

Maximum doses of 5% solution for adults: single - 20 drops, daily - 60 drops.

For children over 5 years old, Iodine is prescribed 3-5 drops 2-3 times a day.

Locally Iodine is used:

For irrigation of the nasopharynx - 2-3 times a week for 2-3 months;
For washing and instillation into the ear - the frequency of use is determined by the doctor, the course is 2-4 weeks;
For washing the lacunae and supratonsillar spaces (areas adjacent to the tonsils) - a total of 4-5 procedures, one every 2-3 days;
For burns and in surgical practice, as needed, moisten gauze pads applied to the affected areas.

Side effects

In general, iodine is well tolerated.

When applied externally, skin irritation is rarely noted. With prolonged use on large affected surfaces, iodism may develop, manifested by rhinitis, salivation and lacrimation, urticaria, acne, Quincke's edema.

When taken orally, in some cases, allergic reactions develop due to individual intolerance to iodine preparations, as well as sleep disturbances, nervousness, excessive sweating, tachycardia, and in patients over 40 years of age, diarrhea is possible.

special instructions

The antiseptic effect of iodine is weakened by acidic and alkaline environments, the presence of blood, fat and/or pus.

drug interaction

Iodine is pharmacologically incompatible with white sedimentary mercury, ammonia solutions and essential oils (as a result of such compounds, an explosive mixture is formed).

INSTRUCTIONS
on the medical use of the drug

Р №002591/01-2003

Tradename: Iodine

Compound:

water-alcohol solution containing 5 g of iodine, 2 g of potassium iodide, equal amounts of water and ethyl alcohol 95% up to 100 ml.

Description: transparent liquid of red-brown color, with a characteristic smell.

Pharmacotherapeutic group:

antiseptic.

Pharmacological properties:

alcohol iodine solution contains elemental iodine, which, upon contact with the skin or mucous membranes, turns into iodide, partially volatilizes from the surface due to volatility and the presence of ethyl alcohol. It has a quick bactericidal effect (within 15-60 seconds), as well as an irritating, distracting, resolving infiltrate action.

Indications for use: alcohol solution of iodine is used as an antiseptic, distracting, irritating agent for inflammatory and other diseases of the skin and mucous membranes. With myositis, neuralgia, a distracting effect of the drug is manifested.

Contraindications: hypersensitivity to iodine.

Dosage and administration: alcohol solution of iodine is used externally.

Side effect: the drug with prolonged use can cause iodism (urticaria, runny nose, Quincke's edema, acne, lacrimation and salivation).

Interaction with other drugs:

alcohol iodine solution is incompatible with disinfectants containing mercury, oxidizing agents, alkalis.

Release form: alcohol iodine solution 5% is available in dark glass bottles with a volume of 10 ml.

Name:

Iodine (lodum)

Pharmacological
action:

Elemental iodine has pronounced antimicrobial properties. Elemental iodine preparations are characterized by a pronounced local irritating effect on tissues, and in high concentrations - a cauterizing effect. Local action is due to the ability of elemental iodine to precipitate tissue proteins. Preparations that split off elemental iodine have a much less pronounced irritant effect, and iodides have local irritating properties only in very high concentrations.
The nature of the resorptive action preparations of elemental iodine and iodides is the same. The most pronounced effect in the resorptive action of iodine preparations is on the function of the thyroid gland. With iodine deficiency iodides contribute to the restoration of impaired synthesis of thyroid hormones. With a normal iodine content in the environment, iodides inhibit the synthesis of thyroid hormones, the sensitivity of the thyroid gland to pituitary TSH decreases and its secretion by the pituitary gland is blocked. The effect of iodine preparations on metabolism is manifested by an increase in dissimilation processes. In atherosclerosis, they cause some decrease in the concentration of cholesterol and beta-lipoproteins in the blood; in addition, they increase the fibrinolytic and lipoproteinase activity of blood serum and slow down the rate of blood clotting.
Accumulating in syphilitic gums, iodine contributes to their softening and resorption. However, the accumulation of iodine in tuberculous foci leads to an increase in the inflammatory process in them. The excretion of iodine by the excretory glands is accompanied by irritation of the glandular tissue and increased secretion. This is due to the expectorant effect and stimulation of lactation (in small doses). However, in large doses, iodine preparations can cause lactation suppression.

Pharmacokinetics
Upon contact with the skin or mucous membranes, 30% turns into iodides, and the rest into active iodine. Partially absorbed. The absorbed part penetrates into tissues and organs and is selectively absorbed by the thyroid gland. It is excreted mainly by the kidneys, intestines, sweat and mammary glands.

Indications for
application:

Iodine preparations are used externally and internally:
Outwardly used as antiseptic (disinfecting), irritating and distracting agents for inflammatory and other diseases of the skin and mucous membranes.
inside- with atherosclerosis, chronic inflammatory processes in the respiratory tract, with tertiary syphilis, hyperthyroidism (thyroid disease), for the prevention and treatment of endemic goiter (thyroid disease due to low iodine content in water), with chronic mercury and lead poisoning.

Mode of application:

For external use iodine treat damaged areas of the skin.
For oral administration the dose is set individually, depending on the indications and the age of the patient.
Locally used for washing lacunae and supratonsillar spaces - 4-5 procedures at intervals of 2-3 days, for irrigation of the nasopharynx - 2-3 times a week for 2-3 months, for instillation into the ear and washing - for 2-4 weeks; in surgical practice and in case of burns, gauze wipes applied to the affected surface are moistened as needed.

Side effects:

For external use: rarely - skin irritation; with prolonged use on extensive wound surfaces - iodism (rhinitis, urticaria, Quincke's edema, salivation, lacrimation, acne).
When taken orally: allergic skin reactions, tachycardia, nervousness, sleep disturbances, excessive sweating, diarrhea (in patients over 40 years of age).

Contraindications:

Hypersensitivity to iodine. For oral administration - pulmonary tuberculosis, nephritis, nephrosis, adenomas (including the thyroid gland), furunculosis, acne, chronic pyoderma, hemorrhagic diathesis, urticaria, pregnancy, children under 5 years of age.

Interaction
other medicinal
by other means:

Pharmaceutically incompatible with essential oils, ammonia solutions, white sedimentary mercury (an explosive mixture is formed). Alkaline or acidic environment, the presence of fat, pus, blood weaken the antiseptic activity. Weakens the hypothyroid and strumagenic effects of lithium preparations.

Pregnancy:

Contraindicated for oral administration during pregnancy.

Iodine is a drug that has a locally irritating, anti-inflammatory, antiseptic, pronounced antimicrobial and, in high concentrations, a cauterizing effect. It has bactericidal activity against gram-positive and gram-negative microflora (especially Proteus spp., Escherichia coli and Streptococcus spp.), pathogenic fungi and yeasts. Causes the death of spores of the pathogen Bacillus anthracis.

Release form and composition

Dosage form Iodine - 5% alcohol solution.

Ingredients: iodine, potassium iodide, 95% ethanol, purified water.

Indications for use

According to the instructions for Iodine, indications for the use of the drug are:

For external use: abrasions, injuries, wounds, myalgia, infectious and inflammatory skin lesions, inflammatory infiltrates, myositis, neuralgia;
For local use: purulent otitis, atrophic rhinitis, chronic tonsillitis, varicose and trophic ulcers, wounds, chemical and thermal burns of I-II degrees, infected burns;
For oral administration: tertiary syphilis, atherosclerosis (treatment and prevention).

In addition, Iodine is used to disinfect the surgeon's fingers, the edges of wounds and the surgical field (before and after surgery), for antiseptic treatment of body parts during catheterization, puncture and injection.

Contraindications

Regardless of the method of application, iodine, according to the instructions, is contraindicated in case of hypersensitivity to the drug.

Inside the medicine is prohibited to take:

Children under 5 years old;
Pregnant women;
With pulmonary tuberculosis;
Patients with chronic pyoderma;
With nephritis and nephrosis;
With furunculosis and acne;
Patients with hemorrhagic diathesis;
With urticaria.

Method of application and dosage

When applied externally, iodine lubricates damaged or treated areas of the skin.

Place apply:

For washing the lacunae (recesses on the surface) of the tonsils and supratonsillar spaces (adjacent to the tonsils) - 1 procedure once every 2-3 days, a total of 4-5 procedures are performed;
For irrigation of the nasopharynx - 2-3 times a week, treatment - up to 3 months;
For instillation into the ear and washing - as directed by a doctor;
For gargling - several times a day with an aqueous solution (5 ml of iodine per 50 ml of water);
In surgical practice and for burns - as needed, gauze wipes soaked in Iodine are applied to the affected areas.

If it is necessary to take Iodine orally, the doctor sets the dose in each case individually. The required amount of the drug should be dissolved in milk, taken after meals.

For the prevention of atherosclerosis, adults are prescribed 1-10 drops once or twice a day for 30 days. It is recommended to conduct 2-3 such courses per year. In the treatment of atherosclerosis, usually take 10-12 drops three times a day. With tertiary syphilis, a single dose varies from 5 to 50 drops; Iodine solution should be taken 2-3 times a day.

The maximum single dose for adults is 20 drops, the daily dose is 60 drops.

Children inside Iodine is prescribed 3-5 drops per 1/2 cup of milk 2-3 times a day.

Side effects

In most cases, the drug is well tolerated.

When Iodine is taken orally, skin allergic reactions, excessive sweating, sleep disturbance, diarrhea, nervousness, tachycardia can occur, and when taken in high concentrations, a chemical burn occurs.

When applied externally, iodine sometimes causes skin irritation. With hypersensitivity to the drug and with prolonged use on large areas of the body, there is a possibility of developing iodism, manifested by acne, lacrimation, salivation, urticaria, cough, rhinitis, metallic taste in the mouth, thirst, Quincke's edema, diarrhea, general weakness.

special instructions

Iodine is pharmacologically incompatible with white sedimentary mercury, ammonia solutions and essential oils. Such combinations are strictly contraindicated!

Iodine reduces the hypothyroid and strumagenic effects of lithium preparations, and its antiseptic activity is weakened by acidic and alkaline environments, the presence of blood, pus and fat.

The drug should be used very carefully to prevent the solution from getting into the eyes.

High temperature (more than 40 ºС) and light accelerate the decomposition of active iodine.

The diluted solution is not subject to long-term storage.

Analogues

The following medicines belong to the same pharmacological group (“Iodine preparations”) and are characterized by a similar mechanism of action: Aquazan, Braunodin B. Brown, Brownodin B. Brown Povidone-Iodine, Betadine, Yod-Ka, Iodinol, Iodine tablets, Yodovidon, Yodonat , Iodopiron, Iodoflex, Ioduxun, Lugol, Lugol's solution with glycerin, Povidone-iodine, Octasept, Stellanin, Stellanin-PEG, Suliodovizol, Suliodopirone.

Terms and conditions of storage

According to the instructions, the drug should be stored in a dark place at a temperature not lower than 0 ºС. The shelf life of the solution is 3 years.

1. Pharmacological action

Drug group:

Antiseptic drug.

Healing effects of iodine:

Antimicrobial;
Annoying;
Stimulation of thyroxine synthesis.

2. indications for use

The drug is used externally for:

Comprehensive treatment of various diseases of the skin and mucous membranes.

Iodine is used internally for:

, tertiary syphilis, endemic goiter, chronic lead and / or mercury poisoning;
Elimination of chronic inflammatory processes of the respiratory tract;
Prevention of endemic goiter.

Apply a small amount of 5% or 10% solution to the affected areas several times a day;

0.02 g several times a day.

Application Features:

According to the instructions, before starting use, any hypersensitivity reactions to the drug should be completely excluded.

4. Side effects

The immune system:

Phenomena of iodism.

5. Contraindications

6. During pregnancy and lactation

Pregnant women and nursing mothers should use the drug contraindicated.

7. Interaction with other drugs

Clinically significant negative interactions of iodine with other drugs

not described

8. Overdose

Clinically significant symptoms of iodine overdose

not described

9. Release form

Solution for topical or oral use, 5% - 1 ml, 5 ml, 10 ml, 25 ml or 100 ml bottles. 1 PC. or fl. 4, 5, 6, 8, 10 or 12 pcs;
2% - 9 or 18 kg.
Film-coated tablets, 100 or 200 mcg - 48, 60, 96 or 120 pcs.
Chewable tablets, 100 mcg - 30, 45, 90, 120 or 150 pcs.

10. Storage conditions

Dry dark place out of reach of children.

Different, depending on the dosage form and the manufacturer, is indicated on the package.

11. Composition

1 ml solution:

iodine - 50 mg;
Excipients: potassium iodide, ethanol 95%.

1 tablet:

iodine (in the form of potassium iodide) - 100 or 200 mcg.

12. Terms of dispensing from pharmacies

The drug is released without a prescription.

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* Instructions for medical use for the drug Iodine is published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, IT IS NECESSARY TO CONSULT WITH A SPECIALIST