Ibuklin tablets: instructions for use. Can ibuclin be taken if there is no fever? Indications for use

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

INSTRUCTIONS
on the use of a medicinal product for medical use

Registration number:

Trade name of the drug:

INN or grouping name of the drug:

Ibuprofen + Paracetamol

Dosage form:

film-coated tablets

Compound:

Description:

Pharmacotherapeutic group:

combined analgesic (NSAID + analgesic non-narcotic agent).

ATC Code:

Pharmacological properties

Pharmacodynamics

Combined drug, the action of which is due to its constituent components.

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, antipyretic effects. By inhibiting cyclooxygenase (COX) 1 and 2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (mediators of pain, inflammation and hyperthermic reactions), both in the focus of inflammation and in healthy tissues, and suppresses the exudative and proliferative phases of inflammation.

Paracetamol - indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and the mucous membrane of the gastrointestinal tract (GIT). It has an analgesic and antipyretic effect. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.

The effectiveness of the combination is higher than the individual components. Weakens arthralgia at rest and during movement, reduces morning stiffness and swelling of the joints, increases range of motion.

Pharmacokinetics

Ibuprofen.
Absorption - high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). The time to reach maximum concentration (TCmax) after oral administration is about 1-2 hours. Communication with blood plasma proteins - more than 90%. The half-life (T1 / 2) is about 2 hours. It slowly penetrates into the joint cavity, accumulates in the synovial fluid, creating higher concentrations in it than in the blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. undergoes metabolism. More than 90% is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile in the form of metabolites and their conjugates.

Paracetamol.
Absorption is high, plasma protein binding is less than 10% and slightly increases with overdose. Sulfate and glucuronide metabolites do not bind to plasma proteins even at relatively high concentrations. The value of Cmax - 5-20 mcg / ml, TCmax - 0.5-2 hours. It is fairly evenly distributed in body fluids.
Penetrates through the blood-brain barrier.
About 90-95% of paracetamol is metabolized in the liver to form inactive conjugates with glucuronic acid (60%), taurine (35%) and cysteine ​​(3%), as well as a small amount of hydroxylated and deacetylated metabolites. A small part of the drug is hydroxylated by microsomal enzymes to form a highly active N-acetyl-n-benzoquinoneimine, which binds to the sulfhydryl groups of glutathione. With depletion of glutathione reserves in the liver (with an overdose), the enzyme systems of hepatocytes can be blocked, leading to the development of their necrosis. T1 / 2 - 2-3 hours. In patients with cirrhosis of the liver, T1 / 2 increases slightly. In elderly patients, the clearance of the drug decreases and T1 / 2 increases. It is excreted by the kidneys mainly in the form of glucuronide and sulfate conjugates (less than 5% - unchanged). Less than 1% of the accepted dose of paracetamol penetrates into breast milk. In children, the ability to form conjugates with glucuronic acid is lower than in adults.

Indications for use

• febrile conditions (including flu and colds);
• myalgia;
• neuralgia;
• back pain;
• joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system;
• pain with bruises, sprains, dislocations, fractures;
• post-traumatic and postoperative pain syndrome;
• toothache;
• algomenorrhea (painful menstruation).

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Contraindications for use

Increased individual sensitivity to the components of the drug (including other NSAIDs), peptic ulcer of the stomach and duodenum in the acute phase, gastrointestinal bleeding, severe renal failure (creatinine clearance (CC) less than 30 ml / min), complete or incomplete combination bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history), damage to the optic nerve, genetic absence of glucose-6-phosphate dehydrogenase, diseases of the blood system, the period after coronary artery bypass grafting; progressive kidney disease, severe liver failure or active liver disease, confirmed hyperkalemia, active gastrointestinal bleeding, inflammatory bowel disease, pregnancy (third trimester), children under 12 years of age.

Use during pregnancy and lactation

In the I and II trimesters of pregnancy, use is possible only as directed by a doctor in cases where the potential benefit outweighs the possible risk to the mother and the potential risk to the fetus. The use of the drug in the III trimester of pregnancy is contraindicated.
If necessary, the use of the drug during lactation (breastfeeding) should stop breastfeeding.
In experimental studies, the embryotoxic, teratogenic and mutagenic effects of the components of the drug Ibuklin ® have not been established.

Method of application and dosing regimen

Precautions for use

Ischemic heart disease, chronic heart failure, cerebrovascular disease, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, CC less than 60 ml/min, history of gastrointestinal ulcers, presence of Helicobacter pylori infection, old age, long-term use of NSAIDs, alcoholism , severe somatic diseases, simultaneous use of oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline).
Viral hepatitis, hepatic and / or renal failure of moderate and mild severity, benign hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndrome), cirrhosis of the liver with portal hypertension, nephrotic syndrome.

Symptoms of an overdose, measures to help with an overdose

Symptoms: gastrointestinal disorders (diarrhea, nausea, vomiting, anorexia, pain in the epigastric region), increased prothrombin time, bleeding after 12-48 hours, lethargy, drowsiness, depression, headache, tinnitus, impaired consciousness, cardiac disorders rhythm, lowering blood pressure, manifestations of hepato- and nephrotoxicity, convulsions, hepatonecrosis may develop. If you suspect an overdose, you should immediately seek medical help.

Treatment: gastric lavage during the first 4 hours; alkaline drink, forced diuresis; activated charcoal inside, the introduction of donators of SH-groups and precursors of the synthesis of glutathione-methionine 8-9 hours after an overdose and N-acetylcysteine ​​inside or intravenously - after 12 hours, antacids; hemodialysis; symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Possible side effect

From the gastrointestinal tract (GIT): NSAID-gastropathy - nausea, vomiting, heartburn, anorexia, epigastric discomfort or pain, diarrhea, flatulence; rarely - erosive and ulcerative lesions, bleeding; liver dysfunction, hepatitis, pancreatitis; irritation or dryness in the oral cavity, pain in the mouth, ulceration of the mucous membrane of the gums, aphthous stomatitis; constipation.
From the nervous system and sensory organs: headache, dizziness, insomnia, anxiety, nervousness, irritability, agitation, drowsiness, depression, confusion, hallucinations; rarely - aseptic meningitis (more often in patients with autoimmune diseases); hearing loss, tinnitus, visual impairment, toxic damage to the optic nerve, blurred vision or double vision, scotoma, amblyopia.
Since the cardiovascular system: heart failure, increased blood pressure, tachycardia.
On the part of the hematopoietic organs: anemia (including hemolytic and aplastic), thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia.
From the respiratory system: shortness of breath, bronchospasm.
From the urinary system: allergic nephritis, acute renal failure, nephrotic syndrome, edema, polyuria, cystitis.
Allergic reactions: skin rash, itching, urticaria, angioedema, bronchospasm, dyspnea, allergic rhinitis, dryness and irritation of the eyes, conjunctival and eyelid edema, eosinophilia, fever, anaphylactic shock, erythema multiforme exudative (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
Laboratory indicators: a decrease in serum glucose concentration, a decrease in hematocrit and hemoglobin, an increase in bleeding time, an increase in serum creatinine concentration, an increase in the activity of "liver" transaminases.
Other: increased sweating.
With prolonged use in high doses: ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (color vision impairment, scotoma, amblyopia).

Interaction with other drugs and (or) food

With the simultaneous use of the drug Ibuklin ® with drugs, various interaction effects may develop.
When taken simultaneously with acetylsalicylic acid, ibuprofen reduces its anti-inflammatory and antiaggregatory effect (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after the start of administration).
The combination with ethanol, glucocorticosteroids, corticotropin increases the risk of erosive and ulcerative lesions of the gastrointestinal tract.
Ibuprofen enhances the effect of direct (heparin) and indirect (coumarin and indandione derivatives) anticoagulants, thrombolytic agents (alteplase, anistreplase, streptokinase, urokinase), antiplatelet agents, colchicine - the risk of hemorrhagic complications increases.
Enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs.
Weakens the effects of antihypertensive drugs and diuretics (by inhibiting the synthesis of renal prostaglandins).
Increases the blood concentration of digoxin, lithium preparations and methotrexate.
Caffeine enhances the analgesic effect of ibuprofen.
Cyclosporine and gold preparations increase nephrotoxicity.
Cefamandol, cefoperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia.
Antacids and cholestyramine reduce the absorption of the drug.
Myelotoxic drugs contribute to the manifestation of hematotoxicity of the drug.

special instructions

Simultaneous use of the drug with other drugs containing paracetamol and / or non-steroidal anti-inflammatory drugs should be avoided. When using the drug for more than 5-7 days, as directed by a doctor, peripheral blood parameters and the functional state of the liver should be monitored.
With the simultaneous use of indirect anticoagulants, it is necessary to control the parameters of the blood coagulation system.
Avoid co-administration of the drug Ibuklin ® with other NSAIDs.
To avoid possible damaging effects on the liver during the period of taking the drug, you should not drink alcohol.
The drug may distort the results of laboratory studies in the quantitative determination of glucose, uric acid in the blood serum, 17-ketosteroids (the drug must be discontinued 48 hours before the study).

Influence on the ability to drive vehicles, mechanisms

Release form

Film-coated tablets, 400 mg + 325 mg.
10 tablets in PVC/Al blister.
1, 2 or 20 blisters are packed in a cardboard box with instructions for use.

Storage conditions

Best before date

Terms of dispensing from pharmacies

Without recipe.

Manufacturer

Dr. Reddy`s Laboratories Ltd. Hyderabad, Andhra Pradesh, India. Production site address

Dr. Reddy's Laboratories Ltd. Plots No. 137, 138 and 146, Sri Venkateswara Co-operative Industrial Complex, Bollaram, Jinnaram Mandal, Medak District, Andhra Pradesh, India. Consumer claims should be sent to:

Representative office of Dr. Reddy's Laboratories Ltd.: 115035, Moscow, Ovchinnikovskaya emb., 20, building 1

Country of origin

Product group

Combined analgesic (NSAID + non-narcotic analgesic).

Release form

• 10 - blisters (2) - cardboard boxes. Dispersible tablets [for children] 100 mg + 125 mg. 10 tablets in a PVC/A1 blister. 2 blisters are packed in a cardboard box along with instructions for use. pack of 10 tablets

Description of the dosage form

• Capsule-shaped tablets, orange-coated, scored on one side; for individual tablets, marbling is allowed. Tablets are flat-cylindrical, pink, interspersed with a chamfer and a notch on one side and a Fruity-mint odor. Coated tablets

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• Each dispersible tablet [for children] contains: active substances: ibuprofen 100 mg, paracetamol 125 mg excipients: microcrystalline cellulose 20 mg, corn starch 59.04 mg, lactose 5 mg, sodium carboxymethyl starch (type A) 30 mg, crimson dye ( Ponceau 4R) (EI24) 0.2 mg, glycerol 2 mg, colloidal silicon dioxide 5 mg, orange flavor DC 100 pH 1.6 mg, pineapple flavor DC 106 pH 2.5 mg, peppermint leaf oil 0.66 mg, aspartame 10 mg, magnesium stearate 1 mg, talc 3 mg. Each film-coated tablet contains: Active ingredients: ibuprofen 400 mg and paracetamol 325 mg. Excipients: microcrystalline cellulose 120 mg, corn starch 76 mg, glycerol 3 mg, sodium carboxymethyl starch (type A) 7 mg, colloidal silicon dioxide 5 mg, talc 8 mg, magnesium stearate 6 mg. Shell: hypromellose 6 cps 11.32 mg, dye sunset yellow (E110) aluminum lacquer 1.78 mg, macrogol-6000 2.2 mg, talc 4.06 mg, titanium dioxide 0.16 mg, polysorbate-80 0, 16 mg, sorbic acid 0.16 mg, dimethicone 0.16 mg. paracetamol 325 mg ibuprofen 400 mg Excipients: microcrystalline cellulose, corn starch, glycerol, sodium carboxymethyl starch, anhydrous colloidal silicon, talc, magnesium stearate, hypromellose, macrogol, sunset yellow lacquer, titanium dioxide, polysorbate, sorbic acid, dimethicone

Ibuklin indications for use

• - symptomatic therapy of infectious and inflammatory diseases (colds, flu), accompanied by fever, chills, headache, muscle and joint pain, sore throat; - myalgia; - neuralgia; - back pain; - joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system; - pain with bruises, sprains, dislocations, fractures; - post-traumatic and postoperative pain syndrome; - toothache; - algomenorrhea (painful menstruation). The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease

Ibuklin contraindications

• Increased individual sensitivity to the components of the drug (including other NSAIDs), peptic ulcer of the stomach and duodenum in the acute phase, gastrointestinal bleeding, severe renal failure (CC less than 30 ml / min), complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history), damage to the optic nerve, genetic absence of glucose-6-phosphate dehydrogenase, diseases of the blood system, the period after coronary artery bypass grafting; progressive kidney disease, severe liver failure or active liver disease, documented hyperkalemia, active gastrointestinal bleeding, inflammatory bowel disease, children under 12 years of age.

Ibuklin dosage

• 100 mg + 125 mg 400 mg + 325 mg

Ibuklin side effects

• From the gastrointestinal tract (GIT): NSAID-gastropathy - nausea, vomiting, heartburn, anorexia, epigastric discomfort or pain, diarrhea, flatulence; rarely - erosive and ulcerative lesions, bleeding; liver dysfunction, hepatitis, pancreatitis; irritation or dryness in the oral cavity, pain in the mouth, ulceration of the mucous membrane of the gums, aphthous stomatitis; constipation. From the nervous system and sensory organs: headache, dizziness, insomnia, anxiety, nervousness, irritability, agitation, drowsiness, depression, confusion, hallucinations; rarely - aseptic meningitis (more often in patients with autoimmune diseases); hearing loss, tinnitus, visual disturbances, toxic damage to the optic nerve, blurred vision or double vision, scotoma, amblyopia. Since the cardiovascular system: heart failure, increased blood pressure, tachycardia. On the part of the hematopoietic organs: anemia (including hemolytic and aplastic), thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia. From the respiratory system: shortness of breath, bronchospasm. From the urinary system: allergic nephritis, acute renal failure, nephrotic syndrome, edema, polyuria, cystitis. Allergic reactions: skin rash, itching, urticaria, angioedema, bronchospasm, dyspnea, allergic rhinitis, dryness and irritation of the eyes, conjunctival and eyelid edema, eosinophilia, fever, anaphylactic shock, erythema multiforme exudative (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome). Laboratory indicators: a decrease in serum glucose concentration, a decrease in hematocrit and hemoglobin, an increase in bleeding time, an increase in serum creatinine concentration, an increase in the activity of "liver" transaminases. Other: increased sweating. With prolonged use in high doses: ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (color vision impairment, scotoma, amblyopia).

drug interaction

Storage conditions

• store at room temperature 15-25 degrees
• keep away from children

pharmachologic effect

Indications for use

Mode of application

Side effects

Contraindications

Release form

Storage conditions

Nosological classification (ICD-10)

Acute upper respiratory tract infection, unspecified (J06.9)

Influenza caused by an identified influenza virus (J10)

Other specified changes in teeth and their supporting apparatus (K08.8)

Joint pain (M25.5)

Dorsalgia (M54)

Soft tissue diseases associated with exercise, overload and pressure (M70)

Myalgia (M79.1)

Neuralgia and neuritis, unspecified (M79.2)

Primary dysmenorrhea (N94.4)

Secondary dysmenorrhea (N94.5)

From this medical article you can get acquainted with the drug Ibuklin. Instructions for use will explain in which cases you can take the medicine, what it helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Ibuklin, from which you can find out if the medicine helped in the treatment of pain and fever in adults and children. The instructions list the analogues of Ibuklin, the price of the drug in pharmacies, as well as its use during pregnancy.

Ibuklin is an antipyretic, analgesic and anti-inflammatory drug. Instructions for use recommends taking tablets for adults and the children's form Junior to eliminate febrile syndrome and high temperature in case of colds and other infectious and inflammatory ailments, with toothache, headache, joint and muscle pain.

Release form and composition

The drug is produced for children and adults.

Ibuklin for children is produced in the form of round pink interspersed dispersible tablets with a fruity mint odor. Each tablet contains 100 mg ibuprofen and 125 mg paracetamol.

Tablets for adults Ibuklin (instruction for use gives this information) is released in the form of capsule-shaped orange coated tablets. Each tablet contains 400 mg ibuprofen and 325 mg paracetamol.

pharmachologic effect

The action of the drug Ibuklin is due to the pharmacological properties of its active components. Paracetamol and ibuprofen stop the development of inflammatory processes in the body, exerting a pronounced analgesic, antipyretic and anti-inflammatory effect on it.

According to the instructions, the use of Ibuklin leads to a decrease in pain in the joints during movement and at rest, a decrease in their swelling and an increase in the range of motion. This drug has a longer effect than its active substances separately.

What helps Ibuklin?

Indications for the use of the drug Ibuklin include fever (fever syndrome) with colds and other infectious and inflammatory diseases, as well as pain syndrome of mild or moderate intensity of various etiologies:

• headache;
• toothache;
• with diseases of the periarticular tissues (tenosynovitis, bursitis);
• post-traumatic pain syndromes (bruises, sprains, dislocations, fractures, bruises of soft tissues);
• with degenerative diseases of the musculoskeletal system (deforming osteoarthrosis, osteochondrosis);
• lumbago, sciatica, neuralgia, myalgia;
• in inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic, juvenile and chronic arthritis, ankylosing spondylitis, gouty arthritis).

Instructions for use

Ibuklin for adults

Tablets are drunk before meals, or 2-3 hours after meals. Tablets do not need to be chewed, washed down with plenty of water.

Adults need to take one tablet of Ibuklin three times a day. Three tablets is the maximum allowable dose of the drug. At least 4 hours should elapse between taking the tablets. For the elderly and for those who suffer from impaired kidney and liver function, the interval between taking tablets should be at least 8 hours.

Children who are over 12 years old and who have a body weight of more than 40 kg take 1 tablet 2 times a day.

Treatment with Ibuklin to reduce the temperature can last no more than three days. The use of the drug as an anesthetic is possible for no more than five days. If you need to continue therapy, you should always consult with your doctor first.

For kids

Instructions for use of children's Ibuklin are as follows: one tablet of Junior is dissolved in one teaspoon of warm water.

The dosage of Ibuklin Junior for children is made depending on their body weight:

• with a weight of 11-15 kg - 1 tablet 1 time in 8 hours, 3 times a day;
• 16-21 kg - 1 tablet 1 time in 6 hours, 4 times a day;
• 22-40 kg - 2 tablets 1 time in 8 hours, 3 times a day;
• more than 40 kg is taken the minimum dose for adults.

Contraindications

Ibuklin instructions for use prohibits:

• damage to the optic nerve;
• diseases of the blood system;
• confirmed hyperkalemia;
• children's age up to 12 years (tablets for adults);
• children's age up to 3 years (subject to the use of a special children's form Ibuklin Junior);
• III trimester of pregnancy, lactation;
• the period after coronary artery bypass grafting;
• increased individual sensitivity to the components of the drug (including other NSAIDs);
• peptic ulcer of the stomach and duodenum in the acute phase;
• gastrointestinal bleeding;
• inflammatory bowel disease;
• severe renal failure (CC less than 30 ml / min);
• active gastrointestinal bleeding;
• genetic absence of glucose-6-phosphate dehydrogenase;
• complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history);
• progressive kidney disease, severe liver failure, or active liver disease.

Side effects

The medicine can cause such negative reactions of the body:

• hives;
• skin rash;
• dyspeptic phenomena;
• thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis;

Children, during pregnancy and lactation

In the I and II trimesters of pregnancy, use is possible only as directed by a doctor in cases where the potential benefit outweighs the possible risk to the mother and the potential risk to the fetus. The use of the drug in the III trimester of pregnancy is contraindicated.

If necessary, the use of the drug during lactation should stop breastfeeding.

Adult tablets are not prescribed for the treatment of children under 12 years of age. Ibuklin Junior is not prescribed for children under the age of three.

special instructions

Sharing the drug with other drugs containing paracetamol should be avoided. When taking Ibuklin for more than 5-7 days, the functional state of the liver and peripheral blood counts should be monitored.

It is recommended to avoid co-administration with other NSAIDs. In order to avoid damaging effects on the liver during the period of taking Ibuklin, you should not drink alcohol. With the simultaneous appointment of anticoagulants of indirect action, it is necessary to control the parameters of the blood coagulation system.

drug interaction

The use of Ibuklin together with ethanol, corticotropin and glucocorticosteroids increases the risk of developing erosive and ulcerative lesions of the gastrointestinal tract.

Ibuprofen increases the effect of insulin, colchicine, thrombolytic agents, oral hypoglycemic agents, antiplatelet agents, direct and indirect anticoagulants. Caffeine increases the analgesic effect of ibuprofen, while cholestyramine and antacids reduce its absorption in the body.

The use of the drug weakens the effectiveness of diuretics and antihypertensive drugs, but at the same time increases the blood concentration of digoxin, methotrexate and lithium preparations.

Analogues of the drug Ibuklin

According to the structure, analogues are determined:

1. Khairumat.
2. Next.
3. Brustan.

Holiday conditions and price

The average price of Ibuklin (tablets for adults No. 10) in Moscow is 109 rubles. In Kyiv, you can buy medicine for 160 hryvnia. It is problematic to find the drug in Kazakhstan. Pharmacies in Minsk offer Ibuklin (No. 20) for 6-7 bel. rubles. It is released from pharmacies by prescription.

ibuprofen 400 mg, paracetamol 325 mg.

Excipients: corn starch, microcrystalline cellulose, talc, sodium glycolate, colloidal silicon oxide, magnesium stearate, hydroxypropyl methylcellulose, polyethylene glycol, sunset yellow, titanium dioxide, sorbic acid, polysorbate, dimethicone.

pharmachologic effect

Pharmacodynamics

Ibuprofen is a non-steroidal anti-inflammatory drug, a derivative of phenylpropionic acid, has anti-inflammatory, antipyretic and analgesic effects, by inhibiting the activity of COX, the main enzyme responsible for the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to both peripheral (indirectly, through a decrease in the synthesis of prostaglandins) and the central mechanism (inhibition of prostaglandin synthesis in the central and peripheral nervous system). Suppresses platelet aggregation.

Paracetamol is a non-narcotic analgesic that has an analgesic, antipyretic and weak anti-inflammatory effect by suppressing the activity of COX and reducing the production of prostaglandins; It has a predominant effect on the thermoregulatory center in the hypothalamus.

Indications for use

Inflammatory-degenerative diseases of the joints and spine (including rheumatoid and rheumatoid arthritis, osteoarthritis, ankylosing spondylitis), articular syndrome during exacerbation of gout, psoriatic arthritis, tendinitis, bursitis.

Radiculitis, neuralgia, myalgia.

Headache and toothache, pain syndrome in case of injuries, burns, inflammatory diseases of the upper respiratory tract, pelvic organs (adnexitis, algomenorrhea).

Fever in infectious and inflammatory diseases.

Contraindications

Increased individual sensitivity to the components of the drug

Peptic ulcer of the stomach and duodenum in the acute phase

Gastrointestinal bleeding

Severe liver or kidney dysfunction

Aspirin-dependent bronchial asthma

Optic nerve lesions

Genetic absence of glucose-6-phosphate dehydrogenase

Diseases of the blood system

Pregnancy and breastfeeding period

Age up to 14 years (children's form "Ibuklin for children" can be used)

Pregnancy and lactation

during pregnancy and lactation, the use of the drug is not recommended. If it is necessary to take during lactation, it is necessary to resolve the issue of transferring to artificial feeding.

Dosage and administration

Adults Ibuklin is usually prescribed one tablet 3 times a day after meals. The maximum single dose is 2 tablets. The maximum daily dose is 6 tablets. In case of impaired renal or hepatic function, the interval between doses of the drug should be at least 8 hours. The drug should not be taken for more than 5 days as an anesthetic and for more than 3 days as an antipyretic without medical supervision.

Side effect

Digestive organs: nausea, loss of appetite, vomiting, erosive and ulcerative lesions of the gastrointestinal tract may develop, with prolonged use, liver function may be impaired.

CNS: headache, dizziness, sleep disturbance, agitation, visual impairment (color perception disorder, scotoma, amblyopia).

Hematopoiesis: with prolonged use: anemia, thrombocytopenia, leukopenia, neutropenia, agranulocytosis.

Urinary system: with prolonged use, kidney function may be impaired.

Allergic reactions: skin rash, angioedema, rarely aseptic meningitis, bronchospastic syndrome.

All side (unusual) effects of the drug, including those not listed in this leaflet, should be reported to your doctor.

Overdose

Signs of acute poisoning are nausea, vomiting, stomach pain, in severe cases, liver failure and coma develop. If you suspect poisoning, you should immediately seek medical help, if less than 4 hours have passed since the poisoning, you can do a gastric lavage.

Interaction with other drugs

If you need to use Ibuklin while taking other drugs, be sure to consult your doctor. The combination of Ibuklin with other non-steroidal anti-inflammatory drugs, barbiturates, anticonvulsants, rifampicin, hypoglycemic drugs, hormonal contraceptives should be avoided. Ibuprofen, which is part of the composition, can weaken the effect of furosemide, thiazide diuretics, antihypertensive drugs, increase the cytotoxicity of chloramphenicol (levomycetin). Combined use with anticoagulants may enhance their effect. Use in conjunction with potassium-sparing diuretics may cause hyperkalemia. When used together, it is possible to increase the concentration in the blood of digoxin, phenytoin, methotrexate, lithium. When used with metoclopramide, an increase in the concentration of paracetamol in the blood is possible. The hepatotoxic effect of both components may be enhanced by alcohol intake.