Baralgin instructions for use injections intramuscular dose. Baralgin ® M (Baralgin ® M)

The drug Baralgin has a fairly narrow spectrum of its action. As a rule, these are painful manifestations of varying degrees, a manifestation of fever, as well as spasms. The drug Baralgin has an analgesic, non-narcotic medicinal effect. The tablets also have an anti-inflammatory effect.

Some countries are skeptical about the use of such a drug, explaining that the drug not only does not help with the disease, but is also dangerous to human health. But such an opinion is not confirmed by anything.

In what cases is Baralgin allowed to be used?

What helps the drug Baralgin? As noted above, Baralgin tablets have an analgesic and anti-inflammatory effect, as well as an antipyretic effect.

The instruction defines the following indications for use: indications of pain and spasms.
Urinary system and gastrointestinal tract.

indications for diseases in the pelvic area;
indications for arthralgia and myalgia;
indications for menstrual pain;
use after surgery to eliminate pain;
application in case of infectious disease and inflammatory process;
use in trauma
use for burns.

For how long, and in what volume is it allowed to take Baralgin?

The instruction says that the period during which you need to take the drug Baralgin is prescribed by the attending physician. This takes into account the fact from which its use is prescribed:

if an antipyretic effect is necessary, the drug is prescribed for a period of 1-3 days;
if an analgesic effect is necessary, the drug is prescribed for a period of 1–5 days.

Dosage of tablets

The maximum amount of the drug taken is up to six tablets per day. As a rule, you can take three tablets per day.

Baralgin tablets for children over the age of fifteen can be taken in the amount of 1-2 tablets. Baralgin tablets for adults can be taken in the same amount as for children.

Dosage of injections

The injections of the drug contain a solution that can be administered intravenously or intramuscularly.
Injections for children over the age of fifteen are administered in a single volume of up to 5 ml.

Dosage for children and adults

Injections for adults are administered in the same volume as for children. Injections with the drug can be administered in a volume of not more than 10 ml per day.

In what cases is it forbidden to use Baralgin?

The instruction determines that the drug has its own contraindications for use. These include:

Bronchial asthma.
Diseases that are symptomatic of bronchospasm.
Contraindications for edema, rhinitis and urticaria caused by the used: paracetamol, ibuprofen, diclofenac.
Contraindications for renal diseases, as well as liver diseases.
Contraindications during pregnancy.
It is forbidden to take the drug in any form (pills, injections) under the age of fifteen.

Ingredients of the drug

The drug includes such a composition, the interaction of the components of which enhances the pharmacological action. Thus, we can note the following composition of the drug:

the composition includes metamizole sodium;
It has antipyretic, analgesic effect.
the composition includes pitofenone hydrochloride;
It has a myotropic effect.
Contains fenpiverinium bromide.
It has an m-anticholinergic effect.

Baralgin and pregnancy

The drug passes through the placental environment, but after that there is no occurrence of any congenital defect or hereditary disease. Taking into account this fact, it is impossible to say with certainty that Baralgin during pregnancy is harmless. Depending on the trimester, you can highlight your contraindications for use:

1 trimester

The available composition of the drug says about the abstinence from its use in the 1st trimester. Baralgin during pregnancy leads to disturbances at the base of the internal organs of the fetus.
For headaches, a walk in the open air or massage of the neck will help.

2 trimester

As a rule, by the 2nd trimester, the internal organs are fully formed. Based on this, and only if approved by your doctor, Baralgin is allowed during pregnancy. There is only a dosage limit. So, it is allowed to use only one tablet of the drug.

3rd trimester

The composition of the drug determines a complete ban on its use in the 3rd trimester. In renal disorders that may occur during this period, the drug acts only in an aggravating way. The use of Baralgin can cause agranulocytosis, in the presence of which there is an active decrease in the woman's immune system. Also, the drug inhibits platelet synthesis, which can lead to birth bleeding.

drug injections

Injections of the drug are effective for intense painful manifestations. This method is used when a quick effect on pain relief is needed. Baralgin injections can be administered intravenously or intramuscularly. It is necessary to take into account the fact that an allergic reaction and a sharp decrease in blood pressure are possible. Injections of the drug perfectly eliminate painful manifestations, and also relax the smooth muscles of all internal organs. Injections of the drug are used intravenously in case of severe pain.

Baralgin is produced in ampoules, in a volume of 5 ml. Baralgin in ampoules is prescribed under such circumstances: spasmolytic and painful manifestations in the stomach, in the biliary tract, in case of acute degree of pancreatitis, with colic in the kidney area, pathological processes in the menstrual cycle. It should be noted that it is forbidden to use Baralgin in ampoules when there is an individual intolerance, there is a difference in blood pressure. Otherwise, a severe allergic reaction can be observed.

How to inject the drug Baralgin?

Baralgin in ampoules is used intravenously or intramuscularly. As a rule, before using the drug, the ampoule should be held for a little time in the hand. Such a rule is necessary to warm the solution, for a more effective effect. With the introduction of a large dose of the drug, it is necessary to administer the drug slowly, slowly. This is necessary due to the fact that the introduction of a large dose of the drug can lead to a sharp decrease in blood pressure.

With special attention, Baralgin injections should be used intravenously. The introduction must be carried out at a rate of 1 ml per minute. Otherwise, with a rapid introduction, the formation of a collapse is possible. In such administration procedures, the person must be placed in a horizontal position, and the health worker must monitor changes in the patient's condition.

Ampoules of Baralgin are used only under the supervision of a doctor and in stationary conditions. This rule is necessary to avoid negative consequences during treatment.

Drug analogues

All analogues of the drug can be divided into 2 groups:

Analogues based on the active substance.
Analgin, Metamizol, Optalgin, etc.
Analogues, based on the therapeutic effect.
Analgin, Voltaren, Diclofenac, Papaverine, etc.

Side effects

In medicine, the following side effects from the use of the drug are noted:

the occurrence of urticaria;
the occurrence of malignant exudative erythema;
the occurrence of toxic epidermal necrolysis;
the occurrence of anaphylactic shock;
the occurrence of impaired functioning of the renal system;
the occurrence of agranulocytosis, thrombocytopenia of immune origin;
acute interstitial nephritis;
urine excreted from the body acquires a reddish tint;
low blood pressure;
disturbed heart rhythm.

With prolonged use of the drug, the risk of such a pathological condition as agranulocytosis increases. That is why, with the following symptoms, it is necessary to stop taking Baralgin:

increased body temperature;
painful manifestations of the throat;
difficulty swallowing due to pain;
chills;
stomatitis;
vaginitis, proctitis;
ulcerative lesion in the mouth.

The most important rule is that you cannot self-medicate. Any use of this or that drug should be agreed with the attending physician.

Read this leaflet carefully before you start using this medicine.
Save the instructions, they may be needed again.
If you have any questions, please contact your doctor.
This medicine has been prescribed for you personally and should not be shared with others as it may harm them even if they have the same symptoms as you.

INSTRUCTIONS for the medical use of the drug Baralgin® M

Registration number: P N011538/01-140211
Trade name of the drug: Baralgin® M.
International non-proprietary name: metamizole sodium.
Dosage form: tablets.
Compound
One tablet contains:
active substance: metamizole sodium - 500 mg;
Excipients: macrogol 4000 47 mg, magnesium stearate 3 mg.
Description
White to off-white round flat tablets, debossed with BARALGIN-M on one side, notched on the other side and chamfered on both sides.
Pharmacotherapeutic group: analgesic non-narcotic agent.
ATX code: N02BB02.

Pharmacological properties

Pharmacodynamics
Non-narcotic analgesic agent, a derivative of pyrazolone, non-selectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid.
It prevents the conduction of extra-painful and proprioceptive impulses along the Gaulle and Burchard bundles, increases the excitability threshold of the thalamic centers of pain sensitivity, and increases heat transfer.
A distinctive feature is the slight severity of the anti-inflammatory effect, which causes a weak effect on water-salt metabolism (retention of sodium and water ions) and the mucous membrane of the gastrointestinal tract. It has analgesic, antipyretic and some antispasmodic (in relation to the smooth muscles of the urinary and biliary tract) action.
Pharmacokinetics
Metamizole sodium is well and rapidly absorbed from the gastrointestinal tract. After oral administration, metamizole sodium is completely metabolized to form active 4-N-methylaminoantipyrine. The connection of the active metabolite with blood plasma proteins is 50-60%. Predominantly excreted by the kidneys. After taking 1 g of metamizole sodium, the renal clearance for 4-N-methylaminoantipyrine was 5±2 ml/min. The half-life is 2.7 hours.
In therapeutic doses, it passes into breast milk.
In patients with cirrhosis of the liver, the half-life of 4-N-methylaminoantipyrine increased three times and was about 10 hours.

Indications for use

Pain syndrome (mild and moderate severity): including neuralgia, myalgia, arthralgia, biliary colic, intestinal colic, renal colic, injuries, burns, decompression sickness, herpes zoster, orchitis, sciatica, myositis, postoperative pain syndrome, headache, toothache, algomenorrhea.
Feverish syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadflies, etc., post-transfusion complications).

Contraindications

Hypersensitivity to metamizole sodium and other components of the drug, as well as other pyrazolones (phenazone, propyphenazone) or pyrazolidines (phenylbutazone, oxyphenbutazone), including, for example, indications of a history of the development of agranulocytosis when taking one of these drugs.
- Violations of bone marrow hematopoiesis (for example, after treatment with cytostatics) or diseases of the hematopoietic system.
- History of bronchospasm or other anaphylactic reactions (eg, urticaria, rhinitis, angioedema) when taking analgesic drugs such as salicylates, paracetamol, diclofenac, ibuprofen, indomethacin, naproxen.
- Congenital deficiency of glucose-6-phosphate dehydrogenase (risk of hemolysis).
- Children's age (up to 15 years).
- Pregnancy (first and third trimester)
- lactation period
- Acute intermittent hepatic porphyria (risk of developing attacks of porphyria)

Carefully

Arterial hypotension (systolic blood pressure below 100 mm Hg), decrease in circulating blood volume, hemodynamic instability (myocardial infarction, multiple trauma, incipient shock), incipient heart failure, high fever (increased risk of a sharp decrease in blood pressure).
- Diseases in which a significant decrease in blood pressure may be of increased danger (patients with severe coronary heart disease and stenosis of the arteries of the brain).
- Alcoholism.
- Bronchial asthma, especially in combination with concomitant polyposis rhinosinusitis; chronic urticaria and other types of atopy (allergic diseases, in the development of which a significant role belongs to hereditary predisposition to sensitization: hay fever, allergic rhinitis, etc.) (increased risk of developing
anaphylactic/anaphylactoid reactions).
- Alcohol intolerance (reaction to even small amounts of certain alcoholic beverages with symptoms such as itching, watery eyes and severe facial flushing) (increased risk of anaphylactic/anaphylactoid reactions).
- Intolerance to dyes (eg tartrazine) or preservatives (eg benzoates) (increased risk of anaphylactic/anaphylactoid reactions).
- Severe violations of the liver and kidneys (it is recommended to use low doses due to the possibility of slowing down the excretion of metamizole sodium).
- Pregnancy (second trimester).
If you have one of these diseases or conditions, consult your doctor before taking this medicine.

Pregnancy and lactation

Pregnancy
During the first trimester of pregnancy, you can not take Baralgin M. In the second trimester of pregnancy, Baralgin M should be taken according to strict medical indications and if the expected benefit to the mother outweighs the potential risk to the fetus. The use of metamizole sodium in the third trimester of pregnancy is also contraindicated: the possibility of premature closure of the arterial (Batalov) duct and perinatal complications due to the effect on the ability of maternal and fetal platelets to aggregate cannot be ruled out, since metamizole sodium is a cyclooxygenase inhibitor, although weak.
lactation period
After taking Baralgin M, breastfeeding should be stopped for 48 hours.

Dosage and administration

A single dose for adults and adolescents over 15 years of age is 500 mg (1 tablet). The maximum single dose can reach 1000 mg (2 tablets). Unless otherwise prescribed, a single dose may be taken 2-3 times a day. The maximum daily dose is 2000 mg (4 tablets). Duration of admission - no more than 5 days when prescribed as an anesthetic and no more than 3 days as an antipyretic.
The tablets should be taken with a sufficient amount of water.
An increase in the daily dose of the drug or the duration of treatment is possible only under medical supervision.

Side effect

Side effects were classified as follows: very common (≥10%), frequent (≥1,<10%), нечастые (≥0,1, <1%), редкие (≥0,01, <0,1%), очень редкие (<0,01%).
Anaphylactic/anaphylactoid reactions
In rare cases, metamizole sodium can cause anaphylactic or anaphylactoid reactions, which in very rare cases can be severe and life-threatening. They can occur even if the drug was previously taken many times without any complications.
Such drug reactions can develop immediately or several hours after taking metamizole sodium.
Usually, milder anaphylactic or anaphylactoid reactions manifest as skin and mucosal symptoms (itching, burning, flushing, urticaria, edema) or as shortness of breath or gastrointestinal complaints.
Milder reactions can progress to severe forms with centralized urticaria, severe angioedema (especially involving the larynx), severe bronchospasm, cardiac arrhythmias, a sharp decrease in blood pressure (which is sometimes preceded by an increase in blood pressure) and the development of circulatory shock.
In persons with bronchial asthma syndrome with intolerance to analgesic drugs, these reactions usually manifest themselves in the form of asthma attacks.
Other skin and subcutaneous tissue reactions
In addition to the skin manifestations of anaphylactic / anaphylactoid reactions listed above, fixed drug dermatitis can rarely occur, a rash can rarely occur, and in some cases Stevens-Johnson syndrome or Lyell's syndrome (toxic epidermal necrolysis) may develop.
Blood and lymphatic system disorders
Rare: leukopenia, in very rare cases agranulocytosis and thrombocytopenia. These reactions are immunological reactions in nature. They can occur even if the drug was previously taken many times without any complications. Agranulocytosis can threaten the patient's life and even lead to death.
Typical symptoms of agranulocytosis are lesions of the mucous membranes (oral cavity and pharynx, anorectal region and genital organs), sore throat, fever. It should be remembered that if the patient receives antibiotic therapy, then the typical manifestations of agranulocytosis may be minimally pronounced. The erythrocyte sedimentation rate increases significantly, while lymph node enlargement is mild or absent.
Typical symptoms of thrombocytopenia are an increased tendency to bleed and the appearance of petechiae on the skin and mucous membranes.
Isolated hypotonic reactions
Infrequently, after taking the drug, an isolated transient decrease in blood pressure is possible (possibly pharmacologically caused and not accompanied by other manifestations of anaphylactic / anaphylactoid reactions); in rare cases, the decrease in blood pressure can be very pronounced.
Other reactions
In very rare cases, especially in patients with kidney disease, there may be an acute deterioration in kidney function (acute renal failure), in some cases with oliguria, anuria or proteinuria. In some cases, acute interstitial nephritis may occur.
Infrequently, it is possible to stain urine red due to the presence of a metabolite, rubazonic acid, in the urine.

Overdose

Symptoms
In case of overdose, the following symptoms may occur: nausea, vomiting, abdominal pain, decreased kidney function / acute renal failure with oliguria (for example, due to the development of interstitial nephritis), more rarely, symptoms from the central nervous system (dizziness, drowsiness, tinnitus, delirium, impaired consciousness, coma, convulsions) and a sharp decrease in blood pressure (sometimes progressing to shock), as well as heart rhythm disturbances (tachycardia), hypothermia, shortness of breath, acute agranulocytosis, hemorrhagic syndrome, acute liver failure, paralysis of the respiratory muscles. After taking high doses, excretion through the kidneys of a non-toxic metabolite (rubazonic acid) can cause red staining of urine.
Treatment
If no more than 1-2 hours have passed after taking the drug, then you can induce vomiting, wash the stomach through a tube; give saline laxatives, activated charcoal. At overdose the forced diuresis is shown. The main metabolite (4-N-methylaminoantipyrine) can be eliminated by hemodialysis, hemofiltration, hemoperfusion, or plasma filtration. With the development of a convulsive syndrome - intravenous administration of diazepam and high-speed barbiturates.

Interaction with other drugs

With cyclosporine
When used simultaneously with cyclosporine, a decrease in its concentration in the blood may occur, therefore, when they are used together, monitoring of the concentration of cyclosporine in the blood is required.
With other non-narcotic analgesics
Simultaneous use of metamizole sodium with other non-narcotic analgesic drugs can lead to mutual enhancement of toxic effects.
With tricyclic antidepressants, personal contraceptives, allopurinol Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.
With barbiturates, phenylbutazone and other inducers of microsomal liver enzymes Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole sodium.
With sedatives and tranquilizers
Sedatives and tranquilizers enhance the analgesic effect of the drug. Simultaneous use with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hyperthermia.
With drugs that have a high protein binding (oral hypoglycemic agents, indirect anticoagulants, glucocorticosteroids and indomethacin) Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin from the connection with plasma proteins, increases their activity.
With myelotoxic drugs
Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.
With thiamazole and sarcolysin
Thiamazole and sarcolysin increase the risk of leukopenia.
With codeine, H2-histamine receptor blockers and propranolol
Codeine, H2-histamine receptor blockers and propranolol enhance the effects of metamizole sodium.
Radiopaque agents, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium (increased risk of anaphylactic / anaphylactoid reactions).

special instructions

In the treatment of patients receiving cytostatic agents, taking metamizole sodium should be carried out only under the supervision of a physician.
An increased risk of developing hypersensitivity reactions to metamizole sodium is caused by the following conditions:
- bronchial asthma, especially with concomitant polypous rhinosinusitis;
- chronic urticaria;
- alcohol intolerance (hypersensitivity to alcohol);
- intolerance or hypersensitivity to dyes (eg tartrazine) or preservatives (eg benzoate).
In the case of the use of metamizole sodium in such patients, strict medical supervision of their condition is necessary and it is necessary to have the means to provide them with emergency care in case of development of anaphylactic / anaphylactoid reactions.
With prolonged use, it is necessary to control the picture of peripheral blood. Against the background of taking metamizole sodium, the development of agranulocytosis is possible, and therefore, if an unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, erosive and ulcerative lesions of the oral cavity, vaginitis or proctitis, a decrease in the number of neutrophils in the peripheral blood is less than 1500 in mm3 it is necessary to stop taking the drug and consult a doctor.
It is unacceptable to use the drug to relieve acute pain in the abdomen (until the cause is clarified).
In patients with impaired liver and kidney function, it is recommended to avoid taking metamizole sodium in high doses.

Baralgin is a non-narcotic analgesic. The half-life of the drug is 14-15 minutes. The active active ingredient of the injections is metamizole sodium, it is 500 mg in 1 ml of the drug. The ampoule holds 5 ml. Another component is water for injection. The action of the anesthetic is enhanced by the components - this is fenpiverinium bromide and pitofenone hydrochloride. The symbiosis of the components provides the ability to achieve the maximum amount of anesthetic in the blood in a short time.

The pharmacological action of Baralgin injections lasts a long time. The intramuscular injection of Baralgin, thanks to its components, removes spasmodic contractions of smooth muscles and gives an analgesic effect on pain.

How to use correctly

The injections are prescribed by a doctor. They are made with:

Intramuscular administration of baralgin is not painless. First, the contents of the ampoule are heated to body temperature (in order to reduce pain during injection).

Intravenous administration of the drug is allowed in exceptional situations, with the supervision of a health worker. If it enters the blood soon, the action of the drug can cause cardiac arrest.

The rate of entry of the drug into the vein should be up to one milliliter per minute, the procedure is performed when the person is lying down. Breathing parameters, pulse, arterial pressure are analyzed. With the introduction of Baralgin in an amount of more than 2 ml, blood pressure may drop rapidly.

The instruction provides for the use of the drug in injections without medical advice to get rid of the pain of the identified origin. To reduce the temperature, use only according to medical advice. This is done when other antipyretic drugs are ineffective.

For problems with the bladder, the remedy is used if it is known for sure that there is no internal bleeding (the components of the drug can cause an increase in blood loss due to the expansion of the vascular lumen). Intramuscular administration will improve the condition of someone who is experiencing pain from the movement of a stone formation through the ureter. It is allowed to use Baralgin in the absence of a medical recommendation for a maximum of three days. If after this period the pain has not gone away, then it is necessary to contact the doctor as soon as possible to determine the diagnosis and prescribe the correct treatment course.

Doses, frequency of use:

Intramuscularly injected 5 ml twice a day;
Intravenously, the drug is used for renal, biliary colic in an amount of a maximum of 3 ml at a time, Baralgin must be diluted when injected into a vein with an isotonic solution of sodium chloride.

Side effects

Due to improper use of the drug, systemic inhibition of hematopoietic function may occur. A week after continuous use of the drug, a slight anemia appears.

With the introduction of more than the prescribed daily dosage, the renal system suffers, as a result of which urine is not excreted, protein appears in it. Severe cases - the development of toxic nephritis. An abscess may occur with intramuscular injection.

Also the side effects are:

Phlebitis, soreness in the injection area;
Burning sensation, itching;
Leukopenia (sometimes - thrombocytopenia, agranulocytosis);
Quincke's edema;
The appearance of a rash;
Interruptions in the activity of the kidneys - anuria, urine staining in a reddish hue, proteinuria, oliguria, in some cases - acute interstitial nephritis;
The presence of bronchospasm;
Anaphylactoid signs;
Arrhythmia;
A rapid decrease in blood pressure;
Sometimes there are syndromes: Lyell or Stevens-Johnson.

The drug should not be used by pregnant women at any time

With the threat to life existing for the mother, if only baralgin helps, a serious question arises about abortion. Baralgin tablets can be taken by children over 5 years of age. Before this age, you can use the medicine in the form of intravenous or intramuscular injections. In children from the age of three months, with a weight of more than 5 kg, the drug is administered exclusively intramuscularly: 50-100 mg per 10 kilograms of weight (0.1-0.2 ml of 50% solution). A single dose is allowed a maximum of three times a day.

When breastfeeding, you will not have to resort to Baralgin. The components of the product enter the milk and lead to lesions of the internal organs of the child.

Also contraindications are:

Intestinal obstruction, its invagination;
Imperfection of the kidneys, liver;
Angle-closure glaucoma;
Anemia, ischemia in the uncompensated stage;
Bronchial asthma or other diseases that can lead to bronchospasm;
Particularly noticeable susceptibility to pyrazolones, metamizole sodium;
There is a risk of hemolysis in the presence of congenital deficiencies of glucose-6-phosphate dehydrogenase;
Allergies to analgesics - edema, rhinitis, urticaria;
Age category up to three months, weight up to 5 kg;
Instability in the work of the bone marrow;
The likelihood of attacks of porphyria is when using Baralgin by people who have acute intermittent hepatic porphyria;
Reduced blood pressure, hemodynamic disturbances.

Special instructions

With the simultaneous use of cytostatic agents, Baralgin should be treated exclusively under medical supervision. If you need to be treated for a long time, then from time to time the composition of the blood is monitored. When agranulocytosis is caused by the presence of metamizole in the body and its duration is 7 days, it is life-threatening. The occurrence of this condition is not related to the dosage.

Refuse to use Baralgin should be when the temperature rises with chills, pain in the oral cavity, the appearance of erosion on the mucous membranes. Explicit neutropenia also provides for the abolition of the drug. Anaphylaxis is often present in patients with allergic reactions, bronchial asthma in the past. Patients with rashes, rhinosinusitis, intolerances to dyes and alcohol are also at risk. You can not use Baralgin when there is significant pain in the abdominal cavity in the absence of an accurate diagnosis.

Intramuscularly, Baralgin is injected with long needles.

Do not give intravenous injections to patients under the age of 1 year.

Transport management during treatment with Baralgin is possible, but care should be taken at high dosages.

In case of overdose, symptomatic therapy is needed. There is an option to use hemodialysis, forced diuresis. Diazepam is given intravenously if there are convulsions.

Connection with other drugs

Baralgin increases the sedative effect of alcohol. Taking other non-narcotic analgesics together with Baralgin will cause an increase in toxic effects. When taken with cyclosporine, plasma levels need to be monitored.

Baralgin - a drug that has a combined effect on the human body in various types of acute pain syndrome. Thanks to its components, a simultaneous strong analgesic effect and elimination of spasm of smooth muscles are achieved.

Pharmacological composition

The composition of Baralgin includes a potent substance - metamizole sodium (analgin), the action of which is enhanced by two more components - fenpiverinium bromide and pitofenone hydrochloride. The combination of these three components makes it possible in a short time to reach the maximum concentration of an analgesic substance in the human blood, the effect of which lasts for a long time.

Baralgin injections in injections

Intramuscular and intravenous injections are used for acute intense pain that needs to be removed quickly. Intramuscular administration is quite painful, to reduce pain, the solution in the ampoule is preheated to the patient's body temperature.

intercostal neuralgia;
osteochondrosis with severe pain syndrome;
shingles;
sciatica and lumbago;
fractures;
osteoarthritis of destructive origin and osteoporosis;
spasm of the duodenum and stomach with peptic ulcer;
spasm of the bile ducts;
severe renal colic;
algomenorrhea;
reduction of elevated body temperature, if other drugs do not have the desired effect.

Dosage

Children over 15 years of age and adults are injected intravenously with 2 ml of the solution. If necessary, the injection is repeated after 6-8 hours.

Intramuscular injections in a single dose of 2-5 ml are carried out two to three times a day for a course of 5 days, the largest daily dose is 10 ml.

Children are given injections depending on their weight, two to three times a day. Up to a year, the drug is administered only intramuscularly - 0.1-0.2 ml.

Single doses for intramuscular and intravenous injections depending on the body weight of the child

Body weight, kg	Single dose, ml
Body weight, kg	Intramuscular injection	intravenous injection

Contraindications: hypersensitivity, low blood pressure or its fluctuations, severe diseases of the kidneys, liver, cardiovascular system, pregnancy of the 1st and 3rd trimesters, lactation.

In this medical article, you can get acquainted with the drug Baralgin. The instructions for use will explain in which cases you can take injections or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Baralgin, from which you can find out if the medicine helped in the treatment of headache and toothache, with colic and menstruation in adults and children, for which it is also prescribed. The instructions list the analogues of Baralgin, the prices of the drug in pharmacies, as well as its use during pregnancy.

The combined antispasmodic and analgesic drug is Baralgin. Instructions for use suggest taking 500 mg tablets, injections in ampoules for injection for pain relief.

Release form and composition

Baralgin is produced by:

in tablets (10 tablets in a blister), in packs of 10, 20, 50 and 100 tablets;
in solution for intravenous and intramuscular administration (injections in ampoules for injection). Baralgin solution for injection is available in 5 ml dark glass ampoules. In a carton box 5 ampoules.

Until 2009, the drug Baralgin in tablets was registered in the country, which included 3 active ingredients - metamizole sodium, pitofenone, fenpiverinium bromide. Since 2009, the drug Baralgin M has been registered and approved for distribution through the pharmaceutical network, containing only one active ingredient - metamizole sodium.

pharmachologic effect

The active substance belongs to non-narcotic drugs and is a derivative of pyrazolone. The drug has an antipyretic, analgesic and mild anti-inflammatory effect. According to the main mechanism of action, the drug is similar to other non-narcotic analgesics.

Indications for use

What helps Baralgin? Tablets and injections are prescribed if:

fever accompanying infectious and inflammatory pathologies (Baralgin is recommended as part of complex therapy);
spasm of smooth muscles (with intestinal, hepatic and renal colic, spasms of the bladder and ureter);
weak and moderate pain of various origins (headache and toothache, pain with arthritis, radiculitis, myalgia, sciatica, neuralgia);
pain after diagnostic procedures and surgical interventions (Baralgin is prescribed as an adjuvant).

Instructions for use

The duration of admission is not more than 5 days when prescribed as an anesthetic and not more than 3 days as an antipyretic. The tablets should be taken with a sufficient amount of water. An increase in the daily dose of the drug or the duration of treatment is possible only under medical supervision.

Injections in ampoules

Adults and teenagers 15 years of age and older: as a single dose, 1-2 ml of a 50% (500 mg / 1 ml) solution of Baralgin M (intramuscularly or intravenously) is recommended, the daily dose can be up to 4 ml of an injection solution (no more than 2 g), divided into 2-3 doses. The maximum single dose may be 1 g (2 ml of a 50% solution).

Children and newborns: Baralgin M should not be taken by newborns under the age of 3 months or with a body weight of less than 5 kg. For children, Baralgin M is prescribed at a dose of 50-100 mg per 10 kg of body weight (0.1-0.2 ml of a 50% solution). A single dose can be administered up to 2-3 times a day. Before administration, the solution is recommended to be heated to body temperature.

For children aged 3-12 months the introduction is carried out only in / m (body weight of the child is from 5 to 9 kg). If the drug is administered too quickly, a critical drop in blood pressure and shock may occur. In / in the introduction should be carried out slowly (the rate of administration is not more than 1 ml (500 mg of metamizole) per minute) in the supine position, while monitoring blood pressure, pulse and respiratory rate.

Since there is a concern that the fall in blood pressure of non-allergic origin is dose-dependent, the amount of Baralgin M solution more than 2 ml (1 g) should be administered with extreme caution.

Contraindications

As indicated in the instructions, Baralgin is not prescribed in the presence of hypersensitivity to it, with severe renal and hepatic insufficiency, with oppression of bone marrow hematopoiesis, tachyarrhythmia, severe angina, deficiency of glucose-6-phosphate dehydrogenase, chronic decompensated heart failure, prostatic hyperplasia, intestinal obstruction, glacoma closed-angle.

It is also impossible to use the medication for collapse, pregnancy, lactation, megacolon. Baralgin is not administered intravenously to children under 3 months of age, and if the child's weight is less than 5 kg. Do not give tablets to children under 5 liters.

With caution, the drug is prescribed for the aspirin triad, bronchial asthma, liver failure, renal failure, sensitivity to other non-steroids, and a tendency to hypotension.

Side effects

angioedema;
allergic responses;
interstitial nephritis;
anaphylactic shock;
impaired renal function;
exudative erythema;
staining of urine in a red tint;
proteinuria;
immune agranulocytosis;
epidermal toxic necrolysis;
drop in blood pressure;
hives;
arrhythmias;
immune thrombocytopenia (decrease in the number of platelets).

Children, during pregnancy and lactation

During the 1st and 3rd trimesters of pregnancy, Baralgin M cannot be taken. From the fourth to the sixth months of pregnancy, the medication should be taken according to strict medical indications. After taking Baralgin M, breastfeeding should be stopped for 48 hours.

Use in children

Baralgin M should not be taken to newborns under the age of 3 months or with a body weight of less than 5 kg.

For children, Baralgin M is prescribed at a dose of 50-100 mg per 10 kg of body weight (0.1-0.2 ml of a 50% solution). A single dose can be administered up to 2-3 times a day. Before administration, the solution is recommended to be heated to body temperature.

For children aged 3-12 months, the introduction is carried out only intramuscularly (body weight of the child is from 5 to 9 kg). In infants aged 3 to 12 months, the intravenous route is contraindicated.

special instructions

the use of Baralgin can cause urine to turn red, which has no clinical significance and disappears immediately after stopping the drug;
with long-term treatment with Baralgin, control of the composition of peripheral blood is required;
you can not use the drug to relieve acute pain in the abdomen until the causes of the pain syndrome are clarified;
you can not take Baralgin in high doses to patients with impaired liver and kidney function;
there is a high risk of developing intolerance to the drug in patients with chronic urticaria, intolerance to alcohol, dyes and preservatives (benzoate, tartrazine).

drug interaction

The toxicity of the drug increases with simultaneous therapy with oral contraceptives, tricyclic antidepressants and Allopurinol. A decrease in the effectiveness of the drug is observed in the treatment of microsomal enzyme inducers (phenylbutazone, barbiturates).

An increase in the severity of negative reactions is observed in the treatment of other non-narcotic analgesics. The analgesic effect of the drug is enhanced with simultaneous therapy with sedatives. Severe hyperthermia is observed during treatment with phenothiazine derivatives, Chlorpromazine.

Simultaneous treatment with Penicillin, the introduction of colloidal blood substitutes, radiopaque substances is unacceptable. The active component is able to enter into a struggle for communication with proteins in the treatment of indomethacin, glucocorticosteroids, indirect anticoagulants. Propranolol, histamine receptor blockers and Codeine enhance the action of Metamizole Sodium.

Baralgin's analogs

According to the structure, analogues are determined:

Optalgin.
Spazdolzin for children.
Metamizole sodium.

With spasms and colic, analogues can be prescribed:

Analgin.
Maxigan.
Prosidol.
But shpa forte.
Aspisol.
Dicloran.
Platifillin.
Spasmoveralgin Neo.
Rapten Rapid.
Unispaz.
Spasmol.
Spakovin.
Diklovit.
Dexalgin.
Novigan.
Metacin.
Spazmalgon.
Diclofenac.
Spaskurel.
Spazgan.
Took.
Dibazol.
Remidon.
Halidor.
Aprofen.
Papazol.
Spazmonet.
Voltaren.
Diclonac.
Drotaverin.
Naklofen.
Diclomelan.
Bralangin.
Buscopan.
Promedol.

Holiday conditions and price

The average cost of Baralgin (tablets No. 20) in Moscow is 225 rubles. Released by prescription.

It is necessary to store in a place protected from light and out of the reach of children at a temperature of +8 ... +28 C. Shelf life - 4 years.