The results of the use of furadonin avexima in urinary tract and kidney infections. Pharmacological interaction with other drugs. Side effects from the use of Furadonin Akvestima

The modern bactericidal drug furadonin has a fairly wide range of applications in medicine. What diseases does it treat, what does it consist of, how does it act on the body, how to take this medicine and can it be given to pets? This article aims to answer these and other questions.

Composition, cost

Furadonin (international name Nitrofurantoin, in Latin Furadonin) is an effective antimicrobial bactericidal agent that destroys harmful microorganisms at the cellular level and has the following composition:

• Active active ingredient - nitrofurantoin at a dosage of 50 mg or 100 mg;
• Auxiliary components - aerosil, potato starch, calcium stearate and others.

Pharmacological group - synthetic antibacterial drugs.

The release form in the pharmacy is tablets for adults of 0.05 g and 1 mg, the children's version is 0.03 g each, a special suspension with a dosed spoon. A prescription is usually not required to purchase.

Furadonin prices vary by region. So in St. Petersburg, the drug costs from 70 rubles for a package of 20 tablets of 50 or 100 mg, in Yekaterinburg - from 75 to 148 rubles for similar tablets, the cost in Europe is from 0.8 €.

Is it an antibiotic?

Nitrofurantoin is not an antibiotic, its effect on microbes occurs by penetrating into the cell and destroying their DNA and RNA.

From what, indications for use

Let's take a closer look at what pills are taken from. Indications for treatment with furadonin are quite diverse, it helps with cystitis and inflammation of the bladder, is prescribed for men with prostatitis and thrush in women, is used as a diuretic for pyelonephritis, and also so that it does not feel sick during antibiotic treatment.

Instructions for use furadonin

Instructions for use Furadonin is contained inside the package. A detailed annotation to the medicine, illustrated with a photo, is also available on specialized sites on the Internet, as well as on the Wikipedia resource.

Furadonin avexima dosage, how many times a day to drink?

Furadonin avexima 50 mg how many tablets to drink at a time reviews indicate that it is more effective to act according to the prescribed instructions from the doctor, i.e. as a rule, no more than 1 - 2 tablets for adults at a time before meals.

Instructions for use for cystitis

The dosage for cystitis, according to the instructions, is as follows - one tablet (50 or 100 mg) 4 times a day, preferably with meals. The course of treatment is up to eight days.

During pregnancy

Nitrofurantoin tablets during pregnancy, especially in the early stages, are not prescribed. It is also contraindicated during lactation and breastfeeding, since its effects on the child's body have not been studied. Do not recommend this medicine to pregnant women and in the later stages. For babies under 6 years old, the remedy is also contraindicated, and after 6, a special children's syrup is prescribed, which the observing pediatrician will tell you how to dilute.

Analogues for women

Especially for women, there are such analogues of Furadonin - furamag, avexima, monural, nitroxoline, furatsilin, nolicin, furazolidone, kanefron. These drugs are substitutes similar and similar to the agent in question and are essentially the same.

Furagin or furadonin which is better?

Only the attending physician can answer questions about what is better furagin or furadonin and what means faster treatment, since these are drugs of the same antimicrobial synthetic group. Which means which one is better suited depends on the individual characteristics of the organism.

In this article, you can read the instructions for using the drug Furadonin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Furadonin in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Furadonin analogues in the presence of existing structural analogues. Use for the treatment of cystitis and pyelonephritis in adults, children, as well as during pregnancy and lactation.

Furadonin- a broad-spectrum antimicrobial agent, a derivative of nitrofuran. It has a bacteriostatic and bactericidal effect in urinary tract infections. Nitrofurantoin (active ingredient of Furadonin) is active against Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp.

Effective mainly in urinary tract infections.

Pharmacokinetics

Well absorbed from the gastrointestinal tract. Bioavailability is 50% (food increases bioavailability). Metabolized in the liver and muscle tissue. Penetrates through the blood-brain barrier, placental barrier, excreted in breast milk. It is excreted completely by the kidneys (30-50% - unchanged).

Indications

• infectious and inflammatory diseases of the urinary tract (including pyelonephritis, cystitis) caused by microorganisms sensitive to nitrofurantoin.

Release forms

Tablets 50 mg and 100 mg.

Instructions for use and dosage

The dose for adults is 50-100 mg, the frequency of use is 4 times a day. The daily dose for children is 5-7 mg / kg in 4 divided doses. The duration of the course of treatment is 7 days. If necessary, it is possible to continue treatment for another 3 days (only after urine control for sterility). When conducting long-term maintenance treatment, the dose of nitrofurantoin should be reduced.

Side effect

• chest pain;
• cough;
• dyspnea;
• pulmonary infiltrates;
• an asthma attack in patients with a history of asthma;
• feeling of discomfort in the epigastrium;
• anorexia;
• nausea, vomiting;
• stomach ache;
• diarrhea;
• peripheral neuropathy;
• headache;
• dizziness;
• drowsiness;
• leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, megaloblastic anemia (these changes are reversible);
• hives;
• angioedema;
• skin itching;
• rash;
• anaphylactic shock (very rare);
• medicinal fever;
• arthralgia;
• possible flu-like symptoms;
• superinfection of the genitourinary tract, often caused by Pseudomonas aeruginosa.

Contraindications

• severe violations of the excretory function of the kidneys;
• kidney failure;
• oliguria;
• insufficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• early childhood (up to 1 month);
• hypersensitivity to nitrofurantoin;
• heart failure stage 2-3;
• cirrhosis of the liver;
• chronic hepatitis;
• acute porphyria;
• lactation.

Use during pregnancy and lactation

Furadonin is contraindicated for use during pregnancy and lactation (breastfeeding).

special instructions

The risk of developing peripheral neuropathy increases in patients with anemia, diabetes mellitus, electrolyte imbalance, vitamin B deficiency, severe renal failure.

Furadonin should not be used to treat diseases of the cortex of the kidneys, with purulent paranephritis and prostatitis. Nitrofurantoin is not prescribed in combination with drugs that cause impaired renal function.

drug interaction

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect of Furadonin.

Nitrofurantoin is incompatible with fluoroquinolones.

With simultaneous use of drugs that block tubular secretion, reduce the antibacterial effect of nitrofurantoin (by reducing the concentration of nitrofurantoin in the urine) and increase its toxicity (increased concentration in the blood).

Analogues of the drug Furadonin

The drug Furadonin has no structural analogues for the active substance.

Analogues according to the effect (antibacterial drugs, nitrofuran derivatives):

• Furagin;
• Furazidin;
• Furamag;
• Furasol.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

General characteristics. Compound:

Pharmacological properties:

Indications for use:

Important! Get to know the treatment

Dosage and administration:

Application Features:

Side effects:

Interaction with other drugs:

Contraindications:

Overdose:

Storage conditions:

The drug should be stored in a dry, dark place and out of the reach of children at a temperature not exceeding 25 ° C. Shelf life 4 years. After the expiration date, the drug should not be used.

Leave conditions:

On prescription

Package:

10 pieces. - non-cell packing contour.
10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (4) - packs of cardboard.
10 pieces. - cellular contour packings (5) - packs of cardboard.
20 pcs. - cellular contour packings (1) - packs of cardboard.
20 pcs. - jars of dark glass (1) - packs of cardboard.

Instructions for use

Active ingredients

Release form

Tablets

Compound

1 tablet contains: Active substance: nitrofurantoin (furadonin) 50 mg. Excipients: potato starch - 46.15 mg, colloidal silicon dioxide (aerosil) - 2 mg, stearic acid - 1 mg, polysorbate 80 (tween 80) - 0.85 mg.

Pharmacological effect

Antimicrobial agent, a derivative of the nitrofuran group, primarily for the treatment of urinary tract infections. Violates the synthesis of proteins in bacteria and the permeability of the cell membrane. Active against gram-positive and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Escherichia coli, Proteus spp.).

Pharmacokinetics

Absorption from the gastrointestinal tract is good. Bioavailability - 50% (food increases bioavailability). The absorption rate depends on the size of the crystals (the microcrystalline form is characterized by rapid solubility and absorption rate, a short time to reach Cmax in the urine). Communication with plasma proteins - 60%. Metabolized in the liver and muscle tissue. T1/2 - 20-25 min. Penetrates through the placenta, BBB, excreted in breast milk. It is excreted completely by the kidneys (30-50% - unchanged).

Indications

Bacterial infections of the urinary tract (pyelitis, pyelonephritis, urethritis, cystitis); - Prevention of infections during urological operations or examinations (cystoscopy, catheterization, etc.).

Contraindications

Hypersensitivity; - Chronic renal failure; - Heart failure II-III stage; - Cirrhosis of the liver; - Chronic hepatitis; - Deficiency of glucose-6-phosphate dehydrogenase; - Acute porphyria; - Pregnancy; - Lactation period; - Children under 3 years of age.

Use during pregnancy and lactation

The use of the drug during pregnancy and during breastfeeding is contraindicated.

Dosage and administration

Inside, drinking plenty of water, adults - 0.1-0.15 g, 3-4 times / day; children - at the rate of 5-8 mg / kg / day, the daily dose is divided into 4 doses. Higher doses for adults: single - 0.3 g, daily - 0.6 g. In acute urinary tract infections, the duration of treatment is 7-10 days. Preventive, anti-relapse treatment continues, depending on the nature of the disease, from 3 to 12 months. The daily dose in this case is 1-2 mg/kg.

Side effects

Nausea, vomiting, allergic reactions (lupus-like syndrome, arthralgia, myalgia, anaphylaxis, chills, eosinophilia, rash), dizziness, headache, asthenia, nystagmus, drowsiness, interstitial changes in the lungs, broncho-obstructive syndrome, fever, cough, chest pain , hepatitis, cholestatic syndrome, peripheral neuropathy, pancreatitis, pseudomembranous enterocolitis, rarely - abdominal pain, diarrhea.

Overdose

Symptoms: vomiting. Treatment: taking a large amount of liquid leads to an increase in the excretion of the drug in the urine. effective dialysis.

Interaction with other drugs

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect. Incompatibility with fluoroquinolones. Drugs that block tubular secretion reduce the antibacterial effect (by reducing the concentration of nitrofurantoin in the urine) and increase the toxicity (increased concentration in the blood) of the drug.

special instructions

The effect of the drug on the performance of potentially hazardous activities that require special attention and quick reactions During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions (with the appearance of dizziness and drowsiness).

Trade name of the drug:

INN or grouping name:

Dosage form:

Compound:

Description:
tablets of yellow or yellow color with a greenish tinge, flat-cylindrical shape.

Pharmacotherapeutic group:

ATX code: J01XE01

Pharmacological properties

Pharmacokinetics
Absorption from the gastrointestinal tract is good. Bioavailability - 50% (food increases bioavailability). The absorption rate depends on the size of the crystals (the microcrystalline form is characterized by rapid solubility and absorption rate, a short time to reach the maximum concentration in the urine). Communication with plasma proteins - 60%.
Metabolized in the liver and muscle tissue. The half-life is 20-25 minutes. Penetrates through the placenta, the blood-brain barrier, excreted in breast milk. It is excreted completely by the kidneys (30-50% - unchanged).

Indications for use

Contraindications

Dosage and administration

Side effect

Overdose

Interaction with other drugs

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect. Incompatibility with fluoroquinolones.
Drugs that block tubular secretion reduce the antibacterial effect (by reducing the concentration of nitrofurantoin in the urine) and increase the toxicity (increased concentration in the blood) of the drug.

The effect of the drug on the performance of potentially hazardous activities that require special attention and quick reactions

Release form

Storage conditions

Best before date

Terms of dispensing from pharmacies

Manufacturer/organization accepting claims
OAO Irbitsky Chemical Pharmaceutical Plant
623856, Russia, Sverdlovsk region, Irbit, st. Kirova, 172