The effect of Aevit. Pharmacological characteristics of Aevit. How to use Aevita

If the reflection in the mirror is no longer pleasing: the skin is dull and flaky, the hair falls out, and the nails exfoliate and break, it's time to look into the pharmacy. They sell a drug that can restore the impeccability of your attractiveness - vitamins "AEvit".

Pharmacological characteristics of Aevit

The drug has the form of an oily solution, which includes high therapeutic doses of two fat-soluble components:

Vitamin A

Retinol palmitate:

• Provides a normal level of twilight vision.
• Accelerates the division of the epithelium, which leads to the rejuvenation of the cell population of the epidermis and slowing down the processes of keratinization of the skin.
• Normalizes metabolism at the molecular level.
• Promotes bone growth.
• Provides complete structure and functionality of gametes.
• Supports the placenta and fetal development.
• Strengthens the protective functions of the body, increasing cellular and humoral immunity.
• Allows deep hydration of the skin.
• It inhibits the reproduction of infectious agents - pathogenic viruses, bacteria and fungi on the mucous membranes of the respiratory system and the digestive canal.
• Improves blood flow in the capillary network.

Vitamin E

Included as alpha-tocopherol acetate:

• A powerful antioxidant and participant in tissue respiration.
• Activates metabolic processes.
• Serves as a cofactor for many enzymes.
• Has a whitening effect on the skin. Helps in the regeneration of her damage.
• Prevents swelling.
• Eliminates the threat of premature birth.

Vitamin A enhances the antioxidant properties of tocopherol, and the latter protects retinol from oxidation. With their deficiency, pustules and acne appear on the skin, it becomes inflamed, flaky, becomes dry and lifeless.

Dosage forms of Aevita

First of all, aevit is taken for a double blow to flabby skin, obliterating endarteritis and thrombosis. The immunostimulating and antioxidant complex helps with problems with the nutrition of peripheral tissues, supports vision and reproductive functions, and affects the metabolism of fats and proteins. In order to avoid overdose and hypervitaminosis, the use of the drug inside is possible only after consulting a doctor. Outdoor use is safer.

In pharmacies, the drug is sold in the form of:

• gelatin capsules containing 100 mg of tocopherol and 100,000 IU of retinol;
• ampoules with an oily solution (1 ml) with 35 mg (A) and 105 mg (E).

Why take Aevit

Aevit vitamins will benefit those who want to:

• Cure lupus erythematosus, necrotizing myopathy, asthenia of any nature, peripheral neuropathy, eye pathologies.
• Overcome intense workloads.
• Recover quickly after a long illness.
• Resist time and rejuvenate mature skin. The drug will eliminate the influence of free radicals, activates metabolism, nutrition and tissue regeneration.
• Get rid of rashes, pustules, acne and other forms of problematic epidermis.
• Increase cellular immunity, normalize the functioning of the sebaceous glands.
• Have hydrated skin, relieve it of peeling. The complex will improve lipid metabolism.
• Find a cure for split ends.
• Strengthen and heal nails.

Aevit is also used in the treatment of:

• seborrhea;
• hypersecretion of sebum;
• eczema;
• scaly lichen;
• cirrhosis of the liver;
• obstructive jaundice;
• Crohn's disease;
• prolonged stress;
• dependence on alcohol and smoking;
• atherosclerosis;
• acute and chronic infectious diseases;
• digestive disorders;
• menstrual irregularities.

The complex helps to maintain vision, stop photophobia, and eliminate night blindness.

How to take Aevit

Aevit capsules are taken orally after meals, on average, one per day, washed down with water. The maximum course of treatment is 40 days. The duration of administration and dosage depend on the diagnosis and physical condition of the patient and are prescribed by the doctor. After six months, the treatment can be repeated.

The oil solution is taken intramuscularly, 1 ml for 20-40 days, repeated after six months. This method minimizes the risk of developing allergies and provides better penetration into the bloodstream. Before the procedure, the ampoule is warmed in the hands for several minutes.

Aevit in cosmetology

Tocopherol improves the functioning of the gonads, which affects the condition of the skin of the whole body - it becomes elastic and fresh. Retinol promotes the processes of tissue regeneration, which also tightens, heals and rejuvenates the skin, tightens pores.

Now let's talk about how to take Aevit. You need to start with testing, for which you apply a drop of oil on the inner surface of the elbow bend. The absence of signs of allergy during the day is a permission for the use of the drug for anti-aging purposes. It remains to pierce the capsule with a needle and apply a drop of the oil composition to each problem area of ​​the face, including the area around the eyes. Course duration - 10 days, maximum 40.

The effect in the form of getting rid of acne and other skin problems can be observed after 2 weeks of daily use. The achieved result will not disappear if the procedures are carried out with a frequency of 1 time in 7-10 days.

Aevit mixture with any cream is prepared for single use only. After thoroughly mixing part of the product with 2-3 drops of oil, a composition is obtained that is applied before going to bed on cleansed facial skin. These procedures are considered preventive, not curative, so they can be carried out indefinitely. They will slow down the aging of the body and improve its general condition.

To care for mature skin, anti-aging masks are prepared with the addition of 3-4 drops of vitamins. After 20 minutes, the composition is washed off with warm water. Procedures are done with a frequency of 1 time per week. A pronounced visual effect in the form of an improvement in the skin condition appears after a course of 10 applications, which will only have to be fixed.

To be the owner of elastic and shiny curls, you need to take 1 capsule per day for a month and add an oil solution to various caring compositions for 7-10 days.

Aevit is used both pointwise and systemically. Numerous acne can be dealt with by a combination of both methods. Acne is treated according to the scheme: 1 time per day for 30 days. A second course, conducted six months later, will eliminate relapses and consolidate the results of therapy.

Contraindications

The complex should not be taken by patients with pathologies:

• thyroid gland;
• kidneys and liver;
• heart and blood vessels.

It is also prohibited for children under 14 years of age, the elderly over 65, persons with individual intolerance to the components of the drug. Pregnant women, especially in the 1st trimester and nursing mothers, can only be prescribed by a doctor.

Side effects of Aevita

If the instructions for the use of Aevit vitamins are strictly followed, then unpleasant effects and consequences develop extremely rarely. With prolonged use, chronic pancreatitis and cholelithiasis are exacerbated.

Overdose is accompanied by:

• dry skin;
• dizziness;
• drowsiness;
• allergies;
• enlargement of the spleen and liver;
• apathy, increased irritability;
• hyperthermia;
• digestive disorders;
• pain in the joints, especially the legs;
• gait disorders;
• itchy rash cracks on the skin;
• convulsions.

Hypervitaminosis A is dangerous because it can cause deformities in the fetus. The teratogenic effect persists even after discontinuation of the drug, and even for a long time. That is why pregnancy planning can only be a year after taking Aevit. Women in position are forbidden to use the complex for the prevention of vitamin deficiency.

Price and analogues in a pharmacy

A package of a medicine of 20 capsules costs about 100 rubles. In the absence of it in the pharmacy, you can safely use the analogues: the preparations Aevit Mite and Vitaminel. And do not forget that they are all medicines and the first step towards their use should be a consultation with a specialist. Only then, thanks to the unique properties of the vitamin complex and the regularity of the procedures, your “calling card” will again become flawless: silky hair, smooth and radiant skin, and nails full of vitality.

In winter and autumn, a person practically does not eat fresh fruits, as well as vegetables rich in vitamins. Therefore, it is recommended to use special preparations.

Aevit is a tool specifically designed to eliminate the deficiency of vitamin complexes. Often, the question arises, how to take Aevit for children? It is known that the lack of vitamins is especially harmful for the growing organism. In the preparation Aevit, meanwhile, contains a significant amount of vitamins A and E, especially necessary for a small child.

When asked if Aevit can be taken by children, the instruction gives a categorical answer. Use of this product for children is prohibited. What is useful for an adult can cause irreparable harm to a child. Indeed, the drug is enriched with vitamins A and E. But, their dosage is so high that it can have a toxic effect on a fragile children's body.

Retinol, otherwise, vitamin A refers to fat-soluble substances necessary for the regulation of metabolic processes in the mucous membranes of the gastrointestinal tract, such systems as the respiratory and genitourinary. Retinol improves vision at night. Vitamin A is especially important for improving immunity, as it is involved in the production of immunoglobulin, which can protect a person from pathogens penetrating the surface of the skin.

In a newborn baby, the need for retinol is only 400 mcg per day. With age, the required dose increases. In the age period from 1 to 3 years, the need is 450 mcg, 4 - 6 years - 500 mcg. In the presence of medical indications, the recommended dose of the vitamin should not exceed 2000 IU. For example, for burns, it is indicated to apply an oil solution of vitamin A to the affected area several times during the day. In this case, the use of Aevit is allowed.

But, in each capsule of the drug is 100,000 IU. That is, the dose is 5 times the maximum allowable amount of a substance used for medicinal purposes! With an overdose of retinol, a child develops hypervitaminosis, which is characterized by the presence of vomiting, high fever, and increased intracranial pressure. Rashes are noted on the skin, sweating increases significantly, the child constantly wants to sleep. In older children, symptoms such as headache, irritability, reddening of the face, painful sensation in the bone tissues, impaired motor function are added.

Exceeding the dosage of vitamin E is no less dangerous. Tocopherol helps the absorption of nutrients and controls metabolism in muscle tissues and the liver. Thanks to vitamin E, the synthesis of pituitary hormones responsible for the growth and formation of sexual characteristics occurs. It normalizes the activity of the nervous and circulatory system, helps wound healing and protects against inflammatory processes. Especially important is the ability of tocopherol to neutralize the toxic effects of free radicals on the body.

An insufficient amount of the vitamin in childhood leads to anemia, a decrease in natural defenses and, as a result, to frequent infections, as well as colds. For a newborn child, it is necessary to receive 3-4 mg per day, from 1 year to 7 years 7-10 mg. Vitamin E is also taken for medicinal purposes in chronic skin diseases, as well as in malnutrition of newborns. In this case, the dose of the drug for children under the age of 1 year is up to 10 mg per day. However, Aevit capsule contains 100 mg of tocopherol.

It should be clarified that an overdose of a substance is not so common. Signs of an overdose are symptoms such as: dizziness, blurred vision, nausea, headache, diarrhea, severe weakening of the body, pain in the stomach. If you continue to use Aevit for children, it is possible to provoke dysfunction of the thyroid gland and kidneys, necrotic lesions of the intestinal wall, the development of thrombophlebitis, an enlarged liver, and hemorrhages in the retina.

Especially for children, many drugs have been created that can compensate for vitamin deficiencies without leading to their overdose. Aevit is a wonderful drug intended for an adult, sufficiently formed organism, which is not recommended for use in children.

If you carefully study the instructions for the drug, you will notice that the manufacturers have clearly formulated who Aevit is indicated for. Is it possible to give this remedy to children, if there are medical indications, the pediatrician decides.

"Aevit" is a multivitamin complex, which includes vitamins A and E. "Aevit" in capsules and injections improves metabolism, provides oxygen to tissues. Thanks to this, the skin is cleansed, hair and nails are strengthened, and their growth is accelerated.

Vitamin A, which is contained in the multivitamin preparation "Aevit" in capsules and injections, takes an active part in the formation of bone tissue, the functioning of the reproductive system and the formation of visual pigments that provide normal color and twilight vision.

Vitamin E (tocopherol) has an antioxidant effect (removes toxins from the body), participates in the formation of elastic and collagen fibers of the connective tissue, digestive tract, vascular smooth muscles, and also restores capillary circulation and increases tissue resistance to oxygen deficiency.

Who is Aevit intended for?

"Aevit" in capsules or injections is prescribed for a lack of vitamins A and E in the body, the cause of which may be malnutrition, an upset digestive system, and a violation of the absorption of these vitamins.

Also, the drug is effective in muscular dystrophy, vascular atherosclerosis, menstrual irregularities in women and diseases of the reproductive system in men. Apply injections of vitamins "Aevit" from acne and acne in adolescents during puberty.

Vitamin A is involved in growth, bone formation, has a beneficial effect on the development of the embryo, plays an important role in the functioning of the female reproductive system - for this reason, Aevit is prescribed to pregnant women. Retinol also normalizes the growth of the epithelium, helps to start the process of natural cell rejuvenation.

Since vitamins A and E are fat soluble, the excipients in this preparation are soybean or corn oil. The drug has an oily consistency, because its injections are quite painful. In this regard, it is more often used in capsules in a gelatinous shell that does not irritate the stomach wall.

"Aevit" in capsules or injections can be prescribed in combination with other drugs for a number of diseases resulting from beriberi or hypovitaminosis of vitamins A and E, namely:

• prolonged diarrhea;
• chronic cholestasis;
• cirrhosis of the liver;
• obstructive jaundice;
• thyroid disease;
• infectious diseases;
• disorders caused by nicotine, drug or alcohol addiction;
• visual impairment.

A multivitamin complex is prescribed by a doctor individually, depending on the characteristics of the disease and its severity.

"Aevit" to improve skin condition

The condition of our skin depends directly on the general condition of the body, proper nutrition and heredity. Due to a deficiency of vitamins A and E, the skin becomes pale, dry, and flaky. Acne and acne, pustules may also occur. Therefore, this multivitamin preparation for the skin has a beneficial effect.

To improve the condition of the skin, the drug should be taken 1 capsule per day for two weeks. In some cases, acne is prescribed according to an individual scheme.

It can also be used externally to improve skin condition. To do this, you need to prepare a homemade cream with multivitamins "Aevit" for facial skin. Squeeze 1-2 capsules and add their contents to your face cream. Use the received remedy for a month.

In case of problems such as blackheads, acne or pustular rashes, use "Aevit" for the face as a lotion. You just need to pierce the capsule and apply vitamin oil to the skin. It can also help with lips. You just need to apply the contents of the capsule with the drug on the lips.

But you can not abuse the drug for external use. All external procedures using "Aevit" for acne to improve skin health, lip condition should not last more than one month. With longer use, addiction will occur, as a result of which the skin tone support mechanism is disrupted and there will be a need for constant replenishment.

For hair

For hair, it is recommended to take ampoules, not capsules. The composition of the vitamin hair mask based on "Aevita" also includes burdock and linseed oils. They must be taken in equal proportions, mixed and applied with massaging movements to the scalp. Then wrap your head in plastic wrap and a towel. This hair mask should be kept on the head for an hour, then rinse with plenty of water. Hair will become silky, smooth and manageable.

If you have oily hair, beat 1 yolk, 1 teaspoon of alcohol and 1 teaspoon of water, add two capsules of Aevit vitamins there. Apply the mask to your hair and leave for 15-20 minutes. After the mask should be washed off with warm water.

For eyelashes

To make eyelashes thick and fluffy, you can also turn to this vitamin complex for help. Make a small hole in the capsule and carefully apply the oil along the entire length of the eyelashes. The ideal medicine for eyelashes is a mix based on Aevita. Add the contents of Aevit capsules to a mixture of olive, castor, burdock, almond oils and fish oil.

For eyelashes, it is best to take an old tube of mascara, wash it well, pour a mixture of oils into it. Then apply the resulting medicine to the eyelashes with a brush several times a month. This will speed up their growth and improve their condition.

Remember that prevention is the best cure. Therefore, constantly monitor the health of your eyelashes and the quality of the cosmetics that you apply to them.

For nails

"Aevit" is an excellent tool for "resuscitation" not only of hair and skin, but also of nails. For nails, it is used during manicure to soften cuticles. In addition, regular use of the drug makes the nails strong, even and shiny. The drug nourishes and restores dry damaged nails.

Contraindications for use

"Aevit" in capsules and injections internally and externally is not recommended for allergic reactions to the ingredients of the drug, as well as with an excess of vitamins A and E in the body. You can not take it to children under 14 years of age. Take with caution in diseases of the liver (viral hepatitis, cholecystitis), kidneys, thyroid gland (thyrotoxicosis).

Although the instructions for the Aevit multivitamin complex in capsules and injections prohibit women from taking the drug during pregnancy, this issue remains unexplored. Indeed, during pregnancy, the body of the expectant mother requires much more nutrients and vitamins, and therefore the deficiency of vitamins in her body makes it necessary to take vitamin preparations like Aevit.

But pregnant women should take "Aevit" in capsules or injections strictly according to the doctor's prescription, following the instructions that specify how to drink it.

What is the danger of an overdose?

Since vitamins A and E are fat-soluble, they stay in the body for a longer time than water-soluble vitamins. Therefore, they do not need to be consumed daily.

Take "Aevit" in capsules or injections should be strictly in accordance with the instructions, since an overdose of vitamins E and A can cause side effects, including:

• pain in the epigastric region, nausea, vomiting, diarrhea;
• allergic reaction: skin redness, itching and rash;
• drowsiness, lethargy, dizziness, headache, confusion, pain and aches in the bones, increased dryness of the skin and oral mucosa, convulsions.

An overdose of the drug can cause hypercalcemia. Also, the drug should not be taken simultaneously with iron, silver products and alkaline-reactive agents. Therefore, remember that self-treatment even with vitamins is unacceptable. Be sure to consult your doctor before taking.

Much is known about the beneficial effects of vitamins A and E on the body, so Aevit is in demand among adults, especially for skin problems. But is it possible to give such a medicine to a child and how to take Aevit correctly?

Release form

Aevit is available in soft capsules, which are packed 10, 20, 30 or 50 in one pack. Another form of medicine is 1 ml ampoules for injection, but this Aevit is used less frequently.

Compound

Each Aevit capsule contains these two active compounds:

1. Retinol palmitate. This is a form of vitamin A, presented in a dosage of 100,000 IU in one capsule.
2. Alpha tocopherol acetate. Each capsule contains 0.1 g of this form of vitamin E.

They are supplemented with soy, sunflower or corn oil, and the capsules themselves are made from glycerol, gelatin and dyes.

You can learn about the benefits of vitamin A for the human organism from the program of E. Malysheva:

Operating principle

The action of Aevit is provided by its main components:

• Vitamin A required for sharp vision, active growth, strengthening of bone tissue and healing of lesions on the skin. Without its sufficient amount in the body, immunity and the condition of the mucous membranes suffer.
• Vitamin E important for the prevention of inflammatory processes, the functioning of the endocrine organs and the heart, blood clotting, the immune system and maintaining the structure of the vascular walls. In addition, such a substance affects tissue regeneration and improves the absorption of retinol.

When taking Aevit, the condition of vision, blood vessels and skin structure improves. The medicine helps to restore blood circulation in the capillaries, normalize tissue permeability and make them more resistant to hypoxia.

You can learn more about vitamin E from the video below:

Indications

Aevit is used for:

• Deficiency of vitamins E and A in the diet or due to diseases of the gastrointestinal tract.
• Optic nerve atrophy or peripheral neuropathy.
• Infectious diseases to stimulate local immunity.
• Night blindness and other vision problems.
• Problems with trophism and microcirculation in the skin.
• Diseases of the liver.
• Rapid weight loss.
• Psoriasis.
• Ichthyosis.
• Taking iron supplements, cholesteramine, or neomycin.

Often, with vision problems, the baby is prescribed Aevit

At what age is it allowed to take?

Instructions for the use of Aevita contain contraindications for children under 14 years of age. This is due to the fact that the dosage of vitamins in such a medicine is much higher than the norm for children. For example, a child at the age of 2 years needs only 1350 IU of retinol per day, at 4-5 years old - 1600 IU of such a compound, at 7 years old - 2300 IU, and at 11 years old - 3000 IU. Compared with the amount of retinol in one capsule of Aevit (100 thousand IU), it becomes clear that such a medicine threatens with an overdose of vitamin A.

As for the second component, vitamin E is needed by a one-year-old child in a daily amount of 6 mg, and at 3 or 6 years of age, its daily intake should be only 7 mg. If children are already 11 years old, they need 8-10 mg of tocopherol every day. And since in each Aevit capsule such a vitamin is presented in a dose of 100 mg, it is immediately clear that this medicine is not suitable for young children.

Even if a child is deficient in vitamins E and A, and this deficiency is dangerous for his health, it is still unacceptable to give Aevit to babies without a doctor's prescription. The medicine can be used in childhood only for external treatment, for example, lubricate the burn site with the contents of the capsule for faster healing of the skin.

The intake of any vitamins by a child must be agreed with a pediatrician.

Contraindications

Aevit should not be used to prevent a lack of vitamin A or tocopherol, because the dosage of such compounds in this drug is increased (it is considered not preventive, but therapeutic). Appoint Aevit is also impossible when:

• Allergy to any of the components of the drug. If there is an intolerance to retinol or vitamin E, the drug can be dangerous (may provoke an immediate reaction of the body).
• Thyrotoxicosis. Due to the high dosage of tocopherol, the exchange of hormones in the thyroid gland may be disturbed.
• Hypervitaminosis A. Taking Aevit in such a situation will only exacerbate the problem.
• Glomerulonephritis or kidney failure. The disease worsens due to excess intake of vitamin E. Also, allergies that Aevit can provoke are very dangerous for kidney function.
• Cholecystitis. The medicine can thicken bile, which only exacerbates such a disease.
• Viral hepatitis. With this disease, Aevit will have a toxic effect on the liver.
• Decreased levels of prothrombin in the blood. This condition threatens with thrombosis, which can also lead to thrombophlebitis or, which is especially dangerous, to separation of a blood clot and subsequent vascular embolism.
• Breastfeeding. High dosages of vitamins from Aevit will reach the baby through human milk.
• First trimester of pregnancy. It is advised to plan conception no earlier than 6 months after the end of treatment with Aevit.

Side effects

Taking Aevit can cause skin rashes and other allergic reactions, as well as dyspepsia and abdominal pain. If you take the medicine for too long, chronic pathologies such as pancreatitis and cholelithiasis become aggravated. In addition, long-term use of Aevit can cause pain in the bones of the legs and hair loss.

Instructions for use and dosage

Children over 14 years old are given Aevit 1 capsule per day. You do not need to chew the medicine - the capsule should simply be swallowed with water. Meals do not affect the time of ingestion of Aevit.

The duration of taking Aevit should be determined by the doctor, but often the capsules are drunk for quite a long time (up to 40 days). If it is necessary to undergo a second course of treatment, the drug is prescribed after a 3-6-month break.

Aevit should be drunk once a day without chewing the capsule

Overdose

The use of Aevit in children who are not yet 14 years old is threatened by such overdose symptoms:

• Vomit.
• Increased body temperature.
• Loss of appetite.
• Increased sweating.
• Dry mouth.
• Sleepy state.
• Rash on the skin.
• Increased intracranial pressure.
• Headache.
• Nausea.
• Soreness of bones and muscles.
• Peeling of the palms and skin of the lips.
• Exacerbation of pancreatitis or diseases of the gallbladder.
• Dizziness.
• Blurred vision.
• Stomach ache.
• Nervous excitement.
• Liquefaction of the stool.
• The appearance of bleeding.
• Thrombophlebitis.
• Enlargement of the liver.

If such symptoms occur, you should immediately stop using Aevit and seek medical help so that the doctor prescribes symptomatic treatment.

If such symptoms occur, you should immediately stop using Aevit and seek medical help.

Interaction with other drugs

• Receiving Aevit affects the treatment with calcium preparations, provoking an increase in the level of this mineral in the blood.
• The absorption of the active substances of Aevit worsens when neomycin, iron preparations, colestipol, mineral oils or cholestyramine are taken together.
• When prescribing isotretinoin together with Aevit, the risk of toxic effects of vitamin A increases.
• Retinol from Aevit, prescribed together with tetracyclines, often provokes intracranial hypertension.
• The presence of vitamin E in Aevit will increase the effectiveness of treatment with cardiac glycosides, vitamins D and A, nonsteroidal anti-inflammatory drugs, glucocorticoids, and antiepileptic drugs.
• If you use Aevit and anticoagulants at the same time, this will increase the risk of bleeding.

Terms of sale

Aevit is available to any buyer in a pharmacy without the need to present a prescription. But, despite the over-the-counter sale, you should consult a doctor before purchasing such a drug. The price of 20 capsules of this medicine is about 60 rubles.

Storage conditions and shelf life

Aevit should be kept away from small children and direct sunlight at a temperature not exceeding + 25 ° C. The medicine should not be used if its expiration date (it is 2 years) has already expired.

INSTRUCTION AEVIT

pharmachologic effect
Aevit- a complex vitamin preparation with antioxidant and immunostimulating effects. In addition, the components of the drug are involved in various physiological processes in the body, including stimulating the reproduction of epithelial cells and bone growth, are involved in tissue regeneration processes, affect protein and lipid metabolism, and are also necessary to maintain reproductive and visual function. A drug Aevit improves capillary circulation, normalizes the permeability of the vascular wall and tissue trophism. The composition of the drug includes the active components of alpha-tocopherol acetate and retinol palmitate. The mechanism of action and therapeutic effects of the drug are based on the pharmacological properties of the active components that make up its composition.

Retinol palmitate (vitamin A) is a fat-soluble vitamin that regulates tissue metabolism. The drug takes part in the formation of the visual signal, due to the transformation of the opsin protein into rhodopsin, a substance necessary for visual adaptation in the dark. Retinol palmitate has a general strengthening effect, enhances myelopoiesis, stimulates the function of macrophages, increases humoral and cellular immunity, reduces the risk of developing diseases of the mucous membranes of the digestive tract and respiratory system. Due to the presence of a large number of unsaturated bonds in the retinol molecule, the drug takes part in various redox reactions in the body, and also plays an important role in the synthesis of glycosaminoglycans, lipids and proteins. Vitamin A is involved in fat metabolism, in particular, it is involved in the formation of cholesterol. Retinol palmitate has a positive effect on the work of the glands of internal and external secretion, including the effect on the function of the lacrimal, sebaceous and sweat glands, increases the secretion of trypsin and lipase. The drug takes part in the formation of bone tissue and bone growth, and also has a positive effect on reproductive function and is necessary for the normal development of the embryo. Vitamin A has a positive effect on the condition of the skin, in particular, retinol palmitate stimulates the reproduction of epithelial cells, rejuvenates the cell population and helps to reduce the number of cells following the path of terminal differentiation, and also slows down the processes of keratinization.

The antioxidant effect of the drug is due to the presence of a large number of unsaturated bonds in the retinol molecule, due to which it is able to interact with various types of free radicals. In addition, retinol palmitate potentiates the antioxidant effect of tocopherol, which in turn prevents the oxidation of retinol and prevents the development of its pro-oxidant properties and prevents the formation of toxic peroxide products.
Alpha-tocopherol acetate is a fat-soluble vitamin with a pronounced antioxidant effect, as well as regulating metabolic processes in the body. The antioxidant effect of the drug is based on its ability to slow down the oxidation of unsaturated fatty acids, reduce the formation of peroxides and prevent hemolysis of red blood cells. In addition, the protection of cells from the action of peroxide compounds and free radicals is carried out by vitamin E due to the ability of the alpha-tocopherol acetate molecule to integrate into the cell membrane, thus preventing the contact of oxygen and free radicals with unsaturated lipids of cell membranes.
Alpha-tocopherol acetate is a cofactor in various enzyme systems. It has a positive effect on the vascular system, stimulates microcirculation and normalizes tissue trophism, by improving capillary circulation, as well as normalizing tissue and capillary permeability. Vitamin E helps to increase the resistance of tissues to hypoxia due to the stabilization of the mitochondrial membrane and the reduction of oxygen consumption by cells. Mutual potentiation of the actions of vitamin E and ubiquinone was noted. By inhibiting the activity of phospholipase A2 of lysosomes, alpha-tocopherol acetate protects the phospholipid layer of cell membranes from destruction. The drug takes part in the synthesis of nucleic acids, heme, cytochromes and other heme-containing proteins. Vitamin E has an immunostimulatory effect, in particular, alpha-tocopherol acetate stimulates cellular and humoral immunity, increases the activity of T-lymphocytes. Together with retinol palmitate, alpha-tocopherol acetate is involved in the maintenance of reproductive function, it is necessary for normal embryonic development and the formation of the reproductive system.

The pharmacokinetics of the drug is based on the pharmacokinetic properties of its components.
Absorption and distribution: retinol palmitate is absorbed in the gastrointestinal tract after interaction with bile acids, alpha-tocopherol acetate is slowly absorbed in the digestive tract. The bioavailability of alpha-tocopherol acetate is about 50%, the peak plasma concentration of vitamin E is observed 4 hours after oral administration. The components of the drug are evenly distributed in organs and tissues, while the excess of retinol is deposited in the liver.

Alpha-tocopherol acetate is deposited in the liver, muscle and adipose tissue, erythrocytes, testes and adrenal glands.
Metabolism: Retinol acetate is metabolized in the liver to form a number of pharmacologically active and inactive metabolites. Alpha-tocopherol acetate is metabolized in the body to form pharmacologically inactive metabolites.
Excretion: Retinol is excreted as metabolites in bile and urine. Alpha-tocopherol is excreted mainly in the bile and in small amounts in the urine, both unchanged and as metabolites. Retinol is excreted from the body slowly, after a single application, 34% of the dose taken is excreted from the body within 3 weeks.

Indications for use

The drug is indicated for patients who have a reduced intake of vitamins A and E with food due to dietary restrictions or a decrease in the absorption of vitamins A and E in the digestive tract, including under such conditions:
- gastrectomy;
- diarrhea;
- steatorrhea (impaired absorption of fats in the gastrointestinal tract and their increased excretion with feces);
- celiac disease, Crohn's disease, malabsorption syndrome (including malabsorption syndrome that developed against the background of tropical sprue);
- cirrhosis of the liver, obstruction of the biliary tract, chronic cholestasis, obstructive jaundice;
- cystic fibrosis of the pancreas;
- acute and chronic infectious diseases;
- rapid weight loss, unbalanced and malnutrition, including to compensate for the deficiency of vitamins A and E in patients on parenteral nutrition;
- drug addiction, alcoholism, nicotine addiction;
- long-term stress, taking medications, including cholestyramine, colestipol, neomycin, mineral oils and preparations containing iron. In addition, the drug is prescribed to patients on a diet with a high content of polyunsaturated fatty acids in food;
- hyperthyroidism.

In addition, the drug can be prescribed to patients suffering from necrotizing myopathy, peripheral neuropathy and abetalipoproteinemia.

Mode of application

Side effects

Contraindications

Pregnancy

Interaction with other drugs

Overdose

Release form

Storage conditions

Synonyms

main parameters