Fluoxetine analogues for weight loss without prescriptions. What is fluoxetine. Different composition, may coincide in indication and method of application

There are contraindications. Please consult your doctor before taking.

Commercial names abroad (abroad) - Prozac, Sarafem, Fontex (USA), Zactin, Lovan, Fluohexal, Auscap (Australia), Depreks (Turkey), Floxet (Hungary), Flunil, Prodep, Fludac (India), Flutine, Affectine (Israel), Fluox (New Zealand), Fluoxetina (Colombia), Fluzac (Ireland), Fluxen (Ukraine), Fluoxin (Romania), Fontex (Denmark, Norway, Sweden), Ladose (Greece), Philozac (Egypt), Biozac, Deprexetin, Fluval, Biflox, Deprexit, Sofluxen, Floxet, Ranflutin (Bulgaria), Flunisan, Orthon, Refloksetin, Fluoksetin (Macedonia), Seronil (Finland), Lorien (South Africa).

All drugs used in neurology and psychiatry,.

You can ask a question or leave a review about the medicine (please do not forget to indicate the name of the drug in the text of the message).

Preparations containing Fluoxetine (Fluoxetine, ATC code (ATC) N06AB03):

Prozac (original Fluoxetine) - official instructions for use. Prescription drug, information intended for healthcare professionals only!

Clinico-pharmacological group:

Antidepressant.

pharmachologic effect

Antidepressant. It is a selective serotonin reuptake inhibitor, which determines the mechanism of its action. Fluoxetine has practically no affinity for other receptors, for example, α1-, α2- and β-adrenergic receptors, serotonin receptors, dopamine receptors, histamine H1 receptors, m-cholinergic receptors and GABA receptors.

Pharmacokinetics

Suction

After oral administration, it is well absorbed from the gastrointestinal tract. Cmax is reached in 6-8 hours.

Bioavailability when taken orally - more than 60%. Dosage forms of fluoxetine for oral administration are bioequivalent.

Distribution

Plasma protein binding - more than 90%. Distributed throughout the body. Css in plasma is achieved after taking the drug for several weeks. Css after prolonged use of the drug is similar to the concentrations observed at 4-5 weeks of taking the drug.

Metabolism

Intensively metabolized in the liver to norfluoxetine and a number of other unidentified metabolites.

breeding

It is excreted in the urine as metabolites. T1 / 2 of fluoxetine is 4-6 days, and its main active metabolite is 4-16 days.

Indications for use of PROZAC®

• depression of various etiologies;
• bulimia nervosa;
• obsessive-compulsive disorder;
• premenstrual dysphoric disorder.

Dosing regimen

For obsessive-compulsive disorders, the recommended dose is 20-60 mg per day.

For premenstrual dysphoric disorders, the recommended dose is 20 mg per day.

The drug can be taken regardless of food intake.

There are no data on the need to change the dose depending on age.

In patients with impaired liver function, concomitant diseases or taking other drugs, doses should be reduced and the frequency of administration should be reduced.

Side effect

From the digestive system: diarrhea, nausea, vomiting, dysphagia, dyspepsia, taste perversion; in isolated cases - idiosyncratic hepatitis.

From the side of the central nervous system and peripheral nervous system: convulsions, ataxia, bucco-glossal syndrome, myoclonus, tremor, anorexia (up to weight loss), anxiety, accompanied by palpitations, anxiety, nervousness, agitation, dizziness, fatigue (drowsiness, asthenia), violation of the process of concentration and thinking, manic reaction, sleep disturbances (unusual dreams, insomnia); visual disturbances (mydriasis, blurred vision); disorders of the autonomic nervous system (dry mouth, increased sweating, vasodilation, chills), serotonin syndrome (a complex of clinical manifestations of changes in mental state and neuromuscular activity in combination with autonomic disorders of the nervous system).

From the genitourinary system: urination disorders (including frequent urination), priapism / prolonged erection, sexual disorders (decreased libido, delayed or absent ejaculation, lack of orgasm, impotence).

From the endocrine system: impaired secretion of ADH.

Allergic reactions: itching, skin rash, urticaria, anaphylactic reactions, vasculitis, reactions similar to manifestations of serum sickness.

Dermatological reactions: photosensitivity, alopecia.

Other: yawning, ecchymosis.

Contraindications to the use of PROZAC®

• established hypersensitivity to fluoxetine.

Use of PROZAC® during pregnancy and breastfeeding

In experimental animal studies, no direct or indirect negative effects of fluoxetine on the development of the embryo or fetus or on the course of pregnancy have been identified. In vitro and animal studies have not shown evidence of mutagenicity and impaired fertility. Because animal reproduction studies are not always predictive of human response, Prozac should only be used during pregnancy if absolutely necessary.

Fluoxetine is excreted in breast milk, so the drug should be used with caution in nursing mothers.

The effect of fluoxetine on the process of childbirth in humans is unknown.

Application for violations of liver function

In patients with impaired liver function, doses should be reduced and the frequency of administration should be reduced.

Use in children

The safety and efficacy of Prozac in children have not been established.

special instructions

There are reports of skin rashes, anaphylactic reactions, and progressive systemic disorders involving the skin, lungs, liver, and kidneys in patients taking fluoxetine. If a skin rash or other possible allergic reactions appear, the etiology of which cannot be determined, Prozac should be discontinued.

As with other antidepressants, Prozac should be used with caution in patients with a history of epileptic seizures.

When using fluoxetine, there were cases of development of hyponatremia (in some cases, the level of sodium in the blood was less than 110 mmol / l). Basically, such cases were observed in elderly patients and in patients receiving diuretics, due to a decrease in BCC.

In diabetic patients, hypoglycemia was noted during treatment with Prozac, and hyperglycemia after discontinuation of the drug. At the beginning and after the end of treatment with fluoxetine, dose adjustment of insulin and / or hypoglycemic drugs for oral administration may be required.

Results of experimental studies

No evidence of carcinogenicity has been obtained in in vitro and animal studies.

Influence on the ability to drive vehicles and control mechanisms

Psychiatric drugs can affect decision making and driving skills. Patients should be advised to avoid driving a car or operating dangerous machinery until it has been established that the drug does not affect the ability to perform these activities.

Overdose

Symptoms: nausea, vomiting, seizures, dysfunction of the cardiovascular system (from asymptomatic arrhythmias to cardiac arrest), impaired function of the respiratory system and signs of a change in the state of the central nervous system from agitation to coma.

Overdose cases of fluoxetine alone are usually mild, and death has been extremely rare.

Treatment: control of the general condition and cardiac activity along with general symptomatic and supportive therapy. The specific antidote is unknown. The effectiveness of forced diuresis, dialysis, hemoperfusion, cross transfusion is unlikely.

In the treatment of overdose, the possibility of using several drugs should be considered.

drug interaction

Prozac should not be administered simultaneously with MAO inhibitors and for at least 14 days after stopping treatment with MAO inhibitors. After the abolition of fluoxetine and the start of treatment with MAO inhibitors, there should be an interval of at least 5 weeks. If long-term treatment with fluoxetine was carried out and / or the drug was used in high doses, then this interval should be increased. Among patients who previously took fluoxetine and started taking MAO inhibitors after a shorter interval, there were serious cases of the development of serotonin syndrome (the manifestations of which may be similar to NMS), up to a fatal outcome.

Fluoxetine has the ability to inhibit the CYP2D6 isoenzyme. Therefore, treatment with drugs that are metabolized by this system and that have a narrow therapeutic index should be started at the lowest doses if the patient is receiving fluoxetine concomitantly or has taken it within the previous 5 weeks. If fluoxetine is included in the treatment regimen of a patient already taking a similar drug, a dose reduction of the first drug should be considered.

With simultaneous use with Prozac, there is a change in blood concentrations of phenytoin, carbamazepine, haloperidol, clozapine, diazepam, alprazolam, lithium, imipramine and desipramine, and in some cases manifestations of toxic effects were observed. When taking fluoxetine in combination with these drugs, a conservative dose selection of the drug should be provided and the patient's condition should be monitored.

Fluoxetine binds strongly to plasma proteins. Therefore, when prescribing fluoxetine against the background of the use of another drug that binds strongly to plasma proteins, changes in plasma concentrations of both drugs are possible.

With the simultaneous use of fluoxetine with warfarin, an increase in bleeding time was noted. Changes in anticoagulant action (laboratory values ​​and/or clinical signs and symptoms) were inconsistent. As with warfarin in combination with many other medicinal products, close monitoring of blood coagulation parameters should be carried out when starting or stopping fluoxetine treatment during warfarin therapy.

If it is necessary to prescribe other drugs after discontinuation of Prozac, the long half-life of fluoxetine and its active metabolite norfluoxetine should be taken into account and, in this regard, the possibility of developing drug interactions.

Rarely, there have been cases of an increase in the duration of seizures in patients taking fluoxetine during electroshock therapy.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored at room temperature (from 15 ° to 30 ° C), out of the reach of children.

Fluoxetine is a strong antidepressant intended for drug therapy in obsessive and depressive states, which are accompanied by the presence of fears.

The systematic use of this drug helps patients overcome apathy, improve mood, normalize appetite and sleep, reduce feelings of fear and tension.

First encounter with medicine

The active ingredient of the drug is fluoxetine hydrochloride.

The pharmacological property is based on its ability to inhibit the reuptake of serotonin, the main neurotransmitter called the pleasure (or happiness) hormone, into the central nervous system.

It is he who is responsible for a good mood, the absence of tearfulness, pickiness, boredom. The therapeutic effect of the drug improves the patient's psycho-emotional activity and does not affect blood pressure, the functional activity of the heart, does not cause drowsiness and lethargy.

The drug is prescribed for:

• obsessive states;
• various depressions;
• premenstrual dysphoria;
• alcoholism.

Pros and cons of the drug

The main advantages of the drug are:

• lack of hypnotic effect and cardiotoxic action;
• availability in the pharmacy network;
• democratic value.

The disadvantages of the drug include the presence of the following side effects:

• an allergic reaction to the main component of the drug;
• pregnancy;
• breastfeeding a baby;
• pathological processes in the liver and kidneys;
• diabetes mellitus;
• epileptic states.

Such a predominance of "minuses" over "pluses" is a consequence of the fact that this drug is already outdated. To date, the pharmacological industry provides patients with modern analogues of Fluoxsetin, which have the ability to selectively affect the human body.

Why people are looking for fluoxetine analogues

price issue

Fluoxetine is not the cheapest drug (its price is about 300 rubles) and in order to save money, you have to look for more affordable analogues.

Among them, Framex and Flunat can be distinguished - these are more affordable medicines that cost from 100 to 150 rubles, and their low price is due to a less eminent name.

Side effect

A high-quality and proven drug, but it has certain disadvantages, or rather a number of side effects:

• violation of the chair;
• infrequent headaches that appear an hour after ingestion;
• increased heart rate, which can lead to tachycardia;
• overdrying of the mucous membrane;
• blurred vision;
• increase in sweat secretions;
• general malaise;
• in women, when taking the drug, pain in the mammary glands and menstrual irregularities (up to several weeks) were found;
• nausea and vomiting;
• noise in ears;
• constant feeling of fatigue;
• sleep disorders;
• depressive state;
• acne and allergic irritations;
• broken bones;
• sexual apathy (loss of interest in sex).

The list of contraindications is rather big and that is why most people are looking for more harmless analogues. For example, it can be Flunat or Deprex. The preparations are distinguished by their natural composition and less aggressive effect on the patient's body.

Lack of choice

Of course, the last reason why people turn to analogues of this drug is simply its absence on the shelves in pharmacies, since Fluoxetine is a sought-after drug.

If this medicine is not in the pharmacy, then you should pay attention to Profluzak and Fluval, which are identical in their action and composition.

Analogues for the active substance, composition, action

According to the active substance fluoxetine hydrochloride, there are the following analogues:

• Apo-Fluoxetine;
• Bioxetine;
• Deprex;
• Deprenon;
• Flunat;
• Fluval;
• Fluoxetine - Canon;
• Fluoxetine - Nycomed.

Similar medicines in composition and effects on the body:

• Portal, composition: fluoxetine and vitamin supplements;
• Prodep, composition: fluoxetine and calcium;
• Prozac, composition: fluoxetine and sedatives.

Unlike Fluoxetine, almost all similar drugs contain fewer impurities, which means they are more harmless.

TOP - 15 best analogues

Popular analogues:

The question of price and free access

Cheap analogues of the antidepressant Fluoxetine:

• Floksat - 150 rubles;
• Profluzak - 75 rubles.

Over-the-counter fluoxetine analogues:

• Portal;
• Bioxetine.

Domestic analogues:

• Portal;

In this article, you can read the instructions for using the drug fluoxetine. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Fluoxetine in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Fluoxetine analogues in the presence of existing structural analogues. Use for the treatment of bulimia and weight loss in adults, children, as well as during pregnancy and lactation. Interaction of the drug with alcohol.

fluoxetine- an antidepressant of the group of selective serotonin reuptake inhibitors. It has a thymoanaleptic and stimulating effect.

Selectively blocks the reverse neuronal uptake of serotonin (5HT) in the synapses of neurons of the central nervous system. Inhibition of serotonin reuptake leads to an increase in the concentration of this neurotransmitter in the synaptic cleft, enhances and prolongs its action on postsynaptic receptor sites. By increasing serotonergic transmission, fluoxetine inhibits the metabolism of the neurotransmitter by the mechanism of negative membrane communication. With prolonged use, fluoxetine inhibits the activity of 5-HT1 receptors. Weakly affects the reuptake of norepinephrine and dopamine. It does not have a direct effect on serotonin, m-cholinergic, H1-histamine and alpha-adrenergic receptors. Unlike most antidepressants, it does not cause a decrease in the activity of postsynaptic beta-adrenergic receptors.

Effective in endogenous depression and obsessive-compulsive disorders. It has an anorexigenic effect, can cause weight loss. Does not cause orthostatic hypotension, sedation, non-cardiotoxic. A stable clinical effect occurs after 1-2 weeks of treatment.

Compound

Fluoxetine hydrochloride + excipients.

Pharmacokinetics

When taken orally, the drug is well absorbed from the gastrointestinal tract (up to 95% of the dose taken), the use with food slightly inhibits the absorption of fluoxetine. The drug accumulates well in tissues, easily penetrates the blood-brain barrier, binding to plasma proteins is more than 90%. Metabolized in the liver by demethylation to the active metabolite norfluoxetine and a number of unidentified metabolites. It is excreted by the kidneys in the form of metabolites (80%) and the intestines (15%), mainly in the form of glucuronides.

Indications

• depression of various origins;
• obsessive-compulsive disorders;
• premenstrual dysphoria;
• bulimic neurosis.

Release forms

Capsules 10 mg and 20 mg (brand names Lannacher, Canon and others, sometimes erroneously called tablets).

Instructions for use and regimen

The drug is taken orally, at any time, regardless of the meal.

depressive state

The initial dose is 20 mg 1 time per day in the morning, regardless of the meal. If necessary, the dose can be increased to 40-60 mg per day, divided into 2-3 doses (20 mg per day weekly). The maximum daily dose is 80 mg in 2-3 doses.

The clinical effect develops 1-2 weeks after the start of treatment, in some patients it can be achieved later.

Obsessive Compulsive Disorders

bulimic neurosis

The drug is used in a daily dose of 60 mg, divided into 2-3 doses.

For premenstrual dysphoric disorders, the recommended dose is 20 mg per day.

The use of the drug by patients of different ages

There are no data on changes in doses depending on age. Treatment of elderly patients should be started with a dose of 20 mg per day.

Side effect

• atrial flutter;
• flushes of heat;
• hypotension;
• vasculitis;
• diarrhea;
• nausea, vomiting;
• dry mouth;
• dyspepsia;
• dysphagia;
• perversion of taste;
• pain along the esophagus;
• anaphylactic reactions;
• serum sickness;
• anorexia (including weight loss) of the body;
• muscle twitches;
• headache;
• attention disorder;
• dizziness;
• lethargy;
• drowsiness (including hyperdrowsiness, sedation);
• tremor;
• psychomotor agitation;
• hyperactivity;
• ataxia;
• lack of coordination;
• convulsions;
• insomnia (including early morning awakening, initial and average insomnia);
• unusual dreams (including nightmares);
• nervousness;
• tension;
• decreased libido (including lack of libido);
• euphoria;
• orgasm disturbance (including anorgasmia);
• thinking disorders;
• manic disorders;
• skin itching;
• polymorphic skin rash;
• hives;
• cold sweat;
• blurred vision;
• frequent urination (including pollakiuria);
• violation of ejaculation (including lack of ejaculation, dysfunctional ejaculation, early ejaculation, delayed ejaculation, retrograde ejaculation);
• erectile dysfunction;
• gynecological bleeding (including bleeding from the cervix, dysfunctional uterine bleeding, bleeding from the genital tract, menometrorrhagia, menorrhagia, metrorrhagia, polymenorrhea, postmenopausal bleeding, uterine bleeding, vaginal bleeding);
• sexual dysfunction;
• priapism.

Contraindications

• simultaneous reception with MAO inhibitors (and within 14 days after their cancellation);
• simultaneous reception of thioridazine (and within 5 weeks after the abolition of fluoxetine), pimozide;
• pregnancy;
• breastfeeding period;
• severe renal dysfunction (creatinine clearance less than 10 ml / min);
• liver failure;
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
• age up to 18 years;
• hypersensitivity to the drug.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

Use in children

In children and adolescents with depression, other mental disorders, antidepressants, compared with placebo, increase the risk of suicidal thoughts and suicidal behavior. Therefore, the appointment of the drug in childhood refers to contraindications for admission.

special instructions

Careful monitoring of patients with suicidal tendencies is required, especially at the beginning of treatment. The risk of suicide is highest in patients who have previously taken other antidepressants and in patients who experience excessive fatigue, hypersomnia, or restlessness during treatment with fluoxetine. Until a significant improvement in treatment occurs, such patients should be under the supervision of a physician.

In children, adolescents and young people (under 24 years of age) with depression, other mental disorders, antidepressants, compared with placebo, increase the risk of suicidal thoughts and suicidal behavior. Therefore, when prescribing fluoxetine or any other antidepressants in children, adolescents and young adults (under 24 years of age), the risk of suicide should be correlated with the benefits of their use. In short-term studies, the risk of suicide did not increase in people over 24 years of age, and slightly decreased in people over 65 years of age. Any depressive disorder in itself increases the risk of suicide. Therefore, during treatment with antidepressants, all patients should be monitored for early detection of violations or changes in behavior, as well as suicidal tendencies.

Against the background of electroconvulsive therapy, the development of prolonged epileptic seizures is possible.

The interval between the end of therapy with MAO inhibitors and the start of treatment with fluoxetine should be at least 14 days; between the end of treatment with fluoxetine and the start of therapy with MAO inhibitors - at least 5 weeks.

After discontinuation of the drug, its therapeutic concentration in the blood serum may persist for several weeks.

Patients with diabetes may develop hypoglycemia during fluoxetine therapy and hyperglycemia after its withdrawal. Doses of insulin and/or oral hypoglycemic agents may need to be adjusted at the start or after treatment with fluoxetine.

When treating patients with underweight, anorexigenic effects should be taken into account (progressive weight loss is possible).

While taking fluoxetine, you should refrain from drinking alcohol, because. the drug enhances the effect of alcohol.

Influence on the ability to drive vehicles and control mechanisms

Taking fluoxetine can adversely affect the performance of work that requires a high rate of mental and physical reactions.

drug interaction

Fluoxetine and its main metabolite, norfluoxetine, have long half-lives, which must be considered when fluoxetine is combined with other drugs, as well as when it is replaced by another antidepressant.

You can not use the drug simultaneously with MAO inhibitors, incl. antidepressants - MAO inhibitors; furazolidone, procarbazine, selegiline, as well as tryptophan (a precursor of serotonin), since it is possible to develop a serotonergic syndrome, manifested in confusion, hypomania, psychomotor agitation, convulsions, dysarthria, hypertensive crises, chills, tremor, nausea, vomiting, diarrhea.

After the use of MAO inhibitors, the appointment of fluoxetine is allowed no earlier than 14 days. MAO inhibitors should not be used earlier than 5 weeks after the abolition of fluoxetine.

In patients on stable maintenance doses of phenytoin, plasma concentrations of phenytoin increased significantly and symptoms of phenytoin toxicity (nystagmus, diplopia, ataxia, and CNS depression) appeared after initiation of concomitant treatment with fluoxetine.

The combined use of fluoxetine and lithium salts requires careful monitoring of the concentration of lithium in the blood, because. it is possible to increase it.

Fluoxetine enhances the effect of hypoglycemic drugs.

With simultaneous use with drugs with a high degree of protein binding, especially with anticoagulants and digitoxin, it is possible to increase the plasma concentration of free (unbound) drugs and increase the risk of adverse effects.

Analogues of the drug Fluoxetine

Structural analogues for the active substance:

• Apo Fluoxetine;
• Deprex;
• Deprenon;
• Portal;
• Prodep;
• Prozac;
• Profluzak;
• Phloxet;
• Fluval;
• Fluxonil;
• Flunisan;
• Fluoxetine GEXAL;
• Fluoxetine Lannacher;
• Fluoxetine Nycomed;
• Fluoxetine OBL;
• Fluoxetine Canon;
• fluoxetine hydrochloride;
• Framex.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

It seems to suit me. I finish drinking 1 pack, only 3. I drink exclusively according to the doctor's prescription, I was prescribed 1 tab once a day. Maybe in the first 2 days there were side effects, now everything is fine. I feel much better. And yes, I managed to lose a couple of pounds.

Advantages It's cheap
Good for chronic depression
Gone were the bouts of gluttony

Flaws Not

didn’t like that after him men’s potency drops. my husband drank, then even smarprost did not help, he became even more nervous, fell into depression. pleasant little

Antidepressants are a very personal matter. everything is very individual. it's not about good or bad pills, but only whether they are suitable for your body

She treated me with a headache, went through all the circles of hell figuring out the reason ... The neurologist prescribed me fluoxetine (she said the cause of the headache was prolonged depression). I drank according to the instructions, it was a nightmare! I didn’t live, but existed ... I ate, I slept , clouded consciousness, somehow still worked. I was thin to the bone! In general, the headaches did not go away, and I passed such a test! I beg you not to drink to lose weight! Let the extra... She treated me with a headache, went through all the circles of hell figuring out the reason ... The neurologist prescribed me fluoxetine (she said the cause of the headache was prolonged depression). I drank according to the instructions, it was a nightmare! I didn’t live, but existed ... I ate, I slept , clouded consciousness, somehow still worked. I was thin to the bone! In general, the headaches did not go away, and I passed such a test! I beg you not to drink to lose weight! Let the excess weight, but healthy!

Great, lightweight product. Just drink properly. Firstly, it develops its effect in 7-10 days /accumulation dose/, our patients often drop it this week: "Oh, I drink it for 7 days, it does nothing!" And he just reached the healing maximum. After 10 days, they notice that they began to yell ... Great, lightweight product. Just drink properly. Firstly, it develops its effect in 7-10 days /accumulation dose/, our patients often drop it this week: "Oh, I drink it for 7 days, it does nothing!" And he just reached the healing maximum. After 10 days, they notice that they began to yell less, they don’t get annoyed over trifles, they sleep well, everything works out, they start to take care of themselves, smile, joke. You need to drink for at least 1.5-2 months, then see a doctor: decide to continue drinking if your mood is still unstable; or SLOWLY cancel on a decreasing schedule.

Fluoxetine helped me. I drank from depression, besides, I noticeably lost weight. He didn’t cause any side effects in me. I felt great, I didn’t get annoyed because of trifles as before.

I drank fluoxetine Lannacher in order to beat off my appetite and stop worrying about trifles. The usual flu does not help, drinking it - only torturing the liver in vain) Now I want to get off it =) I drank fluoxetine Lannacher in order to beat off my appetite and stop worrying about trifles.
The usual flu does not help, drinking it - only torturing the liver in vain)
Now I want to get off it =)

Fluoxetine price 28 rubles, is it expensive? I have been drinking for two weeks now for weight loss, I am very satisfied. I don’t want to eat at all, I’m losing weight in front of my eyes. Thank you for this drug.

I am very satisfied with the preparation. It seems to me that only he helped my daughter become humanoid. I mean, she's an alcoholic and drank to such an extent that I thought we lost her. And now a completely different person's nerves fell into place, no tantrums. If this drug had been prescribed earlier... I am very satisfied with the preparation. It seems to me that only he helped my daughter become humanoid. I mean, she's an alcoholic and drank to such an extent that I thought we lost her. And now a completely different person's nerves fell into place, no tantrums. If this drug had been prescribed earlier, she might have stopped drinking altogether. Of course, she has breakdowns, but much less often and she began to sleep like normal people at night. I say to this drug S P A S I B O

Fluoxetine is quite expensive, but for me this is important, and when drinking this drug, my condition worsened, chills appeared, wild weakness, I stopped eating Wild Nausea altogether, I had to switch to another Neurofull drug, it seems to work stably and it can be combined with alcohol ( Sorry for the details but... Fluoxetine is quite expensive, but for me this is important, and when drinking this drug, my condition worsened, chills appeared, wild weakness, I stopped eating Wild Nausea altogether, I had to switch to another Neurofull drug, it seems to work stably and it can be combined with alcohol ( quarrel for such details, but on weekends sometimes you really want to, yes, holidays, birthdays, alas, you can’t do without it) of course I know that it’s not desirable, but it’s absolutely impossible with other pills.
Fluoxetine was prescribed by a doctor for depression. There was a difficult moment in life. I had to take this drug. But instead of helping, this drug only worsened my condition. I was indifferent to everything and everyone, then I became aggressive. At work, they began to be afraid of me and avoid communication with me. There were times when she seemed to be behaving normally. But she could break loose at any moment and scream, quarrel simply because of nothing. In general, just terrible. Now I remember and it seems to me that it was a terrible dream. When I stopped drinking Fluoxetine for another two weeks, I left him. Now I just thank the Almighty that I feel fine. For the fact that the roof was not completely demolished. Do not drink this drug.

pharmachologic effect

Antidepressant, a propylamine derivative. The mechanism of action is associated with selective blockade of neuronal reuptake of serotonin in the CNS. Fluoxetine is a weak antagonist of cholino-, adreno- and histamine receptors. Unlike most antidepressants, fluoxetine does not appear to cause a decrease in the functional activity of postsynaptic β-adrenergic receptors. Helps improve mood, reduces feelings of fear and tension, eliminates dysphoria. Does not cause sedation. When taken in average therapeutic doses, it practically does not affect the functions of the cardiovascular and other systems.

Pharmacokinetics

Absorbed from the gastrointestinal tract. Weakly metabolized during the "first pass" through the liver. Eating does not affect the degree of absorption, although it may slow down its rate. C max in plasma is achieved after 6-8 hours. C ss in plasma is achieved only after continuous administration for several weeks. Protein binding 94.5%. Easily penetrates through the BBB. It is metabolized in the liver by demethylation to form the main active metabolite of norfluoxetine.

T 1/2 fluoxetine is 2-3 days, norfluoxetine - 7-9 days. Excreted by the kidneys 80% and through the intestines - about 15%.

Indications

Depression of various origins, obsessive-compulsive disorders, bulimic neurosis.

Dosing regimen

Initial dose - 20 mg 1 time / day in the morning; if necessary, the dose can be increased after 3-4 weeks. The frequency of admission is 2-3 times / day.

Maximum daily dose when taken orally for adults is 80 mg.

Side effect

From the side of the central nervous system: anxiety, tremor, nervousness, drowsiness, headache, sleep disturbances are possible.

From the digestive system: possible diarrhea, nausea.

From the side of metabolism: possible increased sweating, hypoglycemia, hyponatremia (especially in elderly patients and with hypovolemia).

From the reproductive system: decreased libido.

Allergic reactions: possible skin rash, itching.

Others: pain in the joints and muscles, shortness of breath, fever.

Contraindications for use

Glaucoma, atony of the bladder, severe renal dysfunction, benign prostatic hyperplasia, simultaneous administration of MAO inhibitors, convulsive syndrome of various origins, epilepsy, pregnancy, lactation, hypersensitivity to fluoxetine.

Use during pregnancy and lactation

Contraindicated for use during pregnancy and lactation.

Use in children

Overdose

Symptoms: psychomotor agitation, seizures, drowsiness, cardiac arrhythmias, tachycardia, nausea, vomiting.

Other serious symptoms of fluoxetine overdose (whether fluoxetine taken alone or concomitantly with other drugs) included coma, delirium, QT interval prolongation, and ventricular tachyarrhythmia, including ventricular fibrillation and cardiac arrest, decreased blood pressure, syncope, mania, pyrexia, stupor, and a neuroleptic malignant syndrome-like condition

Treatment: specific antagonists to fluoxetine have not been found. Symptomatic therapy is carried out, gastric lavage with the appointment of activated charcoal, with convulsions - diazepam, maintenance of breathing, cardiac activity, body temperature.

drug interaction

With simultaneous use with drugs that have a depressant effect on the central nervous system, with ethanol, a significant increase in the inhibitory effect on the central nervous system is possible, as well as an increase in the likelihood of convulsions.

With simultaneous use with MAO inhibitors, furazolidone, procarbazine, tryptophan, serotonin syndrome may develop (confusion, hypomania, restlessness, agitation, convulsions, dysarthria, hypertensive crisis, chills, tremor, nausea, vomiting, diarrhea).

With simultaneous use, fluoxetine inhibits the metabolism of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin, which leads to an increase in their concentration in blood serum, an increase in their therapeutic and side effects.

With simultaneous use, it is possible to inhibit the biotransformation of drugs metabolized with the participation of the CYP2D6 isoenzyme.

With simultaneous use with hypoglycemic agents, their action may be enhanced.

There are reports of an increase in the effects of warfarin when it is used simultaneously with fluoxetine.

With simultaneous use with haloperidol, fluphenazine, maprotiline, metoclopramide, perphenazine, periciazine, pimozide, risperidone, sulpiride, trifluoperazine, cases of extrapyramidal symptoms and dystonia have been described; with dextromethorphan - a case of the development of hallucinations is described; with digoxin - a case of increasing the concentration of digoxin in the blood plasma.

With simultaneous use with lithium salts, an increase or decrease in the concentration of lithium in the blood plasma is possible.

With simultaneous use, it is possible to increase the concentration of imipramine or desipramine in the blood plasma by 2-10 times (may persist for 3 weeks after the abolition of fluoxetine).

With simultaneous use with propofol, a case is described in which spontaneous movements were observed; with phenylpropanolamine - a case is described in which dizziness, weight loss, hyperactivity were observed.

With simultaneous use, it is possible to enhance the effects of flecainide, mexiletine, propafenone, thioridazine, zuclopenthixol.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

In a dry, dark place at a temperature not exceeding 25°C. Keep out of the reach of children. Shelf life - 3 years.

Application for violations of liver function

Use with extreme caution in patients with impaired liver function.

Application for violations of kidney function

Contraindicated in severe renal impairment. Use with extreme caution in patients with moderate and mild renal impairment.

Use in elderly patients

special instructions

Use with extreme caution in patients with impaired liver and kidney function, with a history of epileptic seizures, cardiovascular diseases.

In patients with diabetes mellitus, a change in blood glucose levels is possible, which requires correction of the dosing regimen of hypoglycemic drugs. When used in debilitated patients while taking fluoxetine, the likelihood of developing epileptic seizures increases.

With the simultaneous use of fluoxetine and electroconvulsive therapy, prolonged epileptic seizures may develop.

Fluoxetine can be used no earlier than 14 days after the abolition of MAO inhibitors. The period after the abolition of fluoxetine before the start of therapy with MAO inhibitors should be at least 5 weeks.

Elderly patients require correction of the dosing regimen.

The safety of fluoxetine in children has not been established.

Avoid drinking alcohol during treatment.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, one should refrain from potentially hazardous activities that require increased attention and rapid psychomotor reactions.