Metronidazole 0.5 instructions for use. General information about the drug. Instructions for use "Metronidazole"

Metronidazole- This is an antimicrobial drug that acts on anaerobic microorganisms, as well as protozoa.

The drug is taken orally, rapidly absorbed in the gastrointestinal tract. There is also a release form in vials for intravenous administration. It also exists in such forms of release as: candles, ointments, gels.

After entering the bloodstream, metronidazole binds to blood proteins, then it is metabolized by the liver, in turn, it is the metabolite (2-oxymetronidazole) that has an antimicrobial and antiprotozoal effect. The elimination half-life of the drug by the kidneys is 8 hours.

The drug is active against:

Drug analogues

Metronidazole- a drug from the group of nitramidazoles, a synthetic derivative of azomycin (Streptomyces spp. is synthesized in nature).

There are many generics (analogues) of the original drug:

• - production in Poland, available in tablets in blister No. 20, 250 mg each (cost in online pharmacies from 70 to 100 rubles ), solution for IV infusion 5 mg/ml 100.0 ( 90-150 rub ).
• Klion- country of origin Hungary, tab. 250 mg No. 20 in a blister ( 58-100 rub ).
• - manufacturer India, solution for intravenous infusion 5 mg / ml 100 ml ( 25-50 rub), gel 10mg 30g ( 130-200 rub), Metrogyl denta gel for gums 20g ( 200-280 mg ).
• Flagin- France, tab. 250 mg #20 ( 110-250 rub ).
• Dazolik- India, tab. 500 mg #10 ( 28-360rub ).
• Meratin– UK, infusion solution 5 mg/ml 100 ml ( 310-650 rub ).
• Ornigil– Ukraine, solution for IV infusions 5 mg/ml 100.0 ( 170-370 rub ).
• Ornidazole- Russia, tab. 500 mg #10 ( 60-170 rub ).
• Efloran– Slovenia, solution for IV infusions 5 mg/ml 100.0 ( 220-500 rub), tab. 400 mg in glass. bottle number 10 (270-450 rub ).
• Tricaside– Canada, caps. 500 mg #15 and #30 ( 120-600 rub) and other drugs.

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Metronidazole indications

Indications for the use of Metronidazole:

• Trichomoniasis (acute, chronic, complicated), including trichomonas vaginitis, urethritis.
• Intestinal and extraintestinal amoebiasis, amoebic liver abscess.
• Giardiasis.
• Gardnelles.
• In combination therapy of fungal infections (including candidiasis or thrush).
• Trichomonas urethritis and vaginitis.
• Balantidiasis.
• For the prevention of complications in the postoperative period with diffuse peritonitis, liver abscess, curettage of the uterus, operations on the pelvic organs.
• Treatment of infectious inflammatory diseases of the pelvic organs (vaginitis, salpingitis, etc. - in women; orchitis, epididymitis, prostatitis, etc. - in men)
• Infections caused by bacteroids, which can affect:
  • musculoskeletal system with symptoms of osteomyelitis, bacterial arthritis;
  • nervous system and cause meningitis, encephalitis and even brain abscess,
  • respiratory system with the phenomenon of pneumonia, accompanied by pleural empyema,
  • cardiovascular system with symptoms of backendocarditis with vegetations on the valvular apparatus of the heart.
• Hyperacid gastroduodenitis, as well as peptic ulcer of the stomach and duodenum caused by Helicobacter pylori.
• As a radiosensitizing agent in oncopathology (resistance or stability of cancer is due to oxygen starvation of tumor cells).
• Cancer treatment according to the Klimchuk method.
• Inflammation of the gums and jaw (periodontitis, gingivitis, etc.).
• For skin diseases (pressure sores, eczema).
• Complex treatment of hemorrhoids, anal fissure.
• Comprehensive therapy for getting rid of alcohol and drug addiction.

Indications for men:

• infection with protozoa:
  • amoebiasis;
  • trichomoniasis urogenital;
  • giardiasis;
  • gardnellosis;
  • ureaplasmosis;
• stomatitis and candidiasis (thrush);
• infectious lesions of the teeth, gums (gingivitis, periodontitis);
• infections caused by bacteroids;
• abdominal infections, including liver abscesses;
• prevention of protozoal and bacterial complications after surgical interventions;
• complex treatment of alcoholism and drug addiction;
• a radiosensitizing agent for oncological diseases, also in the treatment of cancer according to the Klimchuk method.

Instructions for use of tablets

Instructions for use of the drug:

The drug is used during or after meals with milk. The drug is incompatible with alcohol!

Treatment should begin immediately! Protect yourself and your loved ones!

Contraindications of the drug

Contraindications for men:

• Hypersensitivity (allergic reactions) to the components of the drug.
• Lesions of the central nervous system, including organic (various genesis of epilepsy).
• Liver failure (since the drug is metabolized by the liver, cumulation occurs - accumulation and overdose at adequately prescribed doses).

The product is based on bee propolis, which has a pronounced antibacterial, antiviral effect. I like the drug because it is completely natural, on herbs, and this is very important for prevention."

Side effects of the drug

Side effects:

• allergic reactions (allergic rhinitis, bronchial asthma, urticaria, angioedema, atopic dermatitis, etc.);
• from the nervous system: headache, ataxia, depression, dizziness, hyperexcitability, hallucinations, insomnia. With prolonged use - peripheral neuropathy, epileptiform seizures are possible;
• from the gastrointestinal tract: loose stools or vice versa - constipation, accompanied by intestinal colic, possibly a decrease in the patient's appetite. With long-term treatment, the following are possible: pancreatitis, cryptogenic hepatitis;
• from the genitourinary system: polyuria and dysuria, urinary incontinence, cystitis;
• from the immune system: leukopenia, stomatitis (as a result of a decrease in the immune response);
• from the musculoskeletal system: migrating arthralgia.

The use of metronidazole gels and ointments for men

Rules for the use of metronidazole gels and ointments for men:

1. Metronidazole Gel- is available in aluminum tubes of 30 g in cardboard packaging, which contains a leaflet with instructions for use. Contains 10 mg of active ingredient. The gel itself is whitish-green in color, odorless. It is used twice a day, applied to a previously washed and dried surface, the course of therapy is from 20 days to 4 months.
2. Metronidazole ointment- available in aluminum or polymer tubes, in a cardboard box with a leaflet. Produced on a hydrophobic basis, it stays on the surface longer than a cream or gel, moisturizes the damaged area. The composition includes 10 mg of active ingredient. It is applied twice a day on clean, dried skin, the course of therapy is 7-10 days.
3. Metronidazole cream- white, medium-density consistency, hydrophilic base. Produced in a 15 g tube, in a cardboard box with an instruction leaflet. It is recommended to apply on the face, the cream is quickly absorbed and leaves no residue. Also apply twice a day on previously cleansed and dried skin. The duration of therapy is from 20 days to 4 months.

For gels and ointments, it is possible to use by applying an occlusive dressing, which contributes to the hermetic isolation of the affected area of ​​the body from the environment. After applying the gel, the damaged area is covered from above with an impermeable material (rubberized fabric, polyethylene), which should capture another 5-10 cm of healthy skin. After that, the air is “squeezed out” and fixed with a bandage or plaster. Leave for 1.5-2 hours. The procedure can be repeated 2 times / day.

Topical application of creams, ointments and gels minimizes the presence of side effects, since the minimum amount of the drug is absorbed into the blood through the skin.

Instructions for use Metronidazole solution for infusion

Transparent solution with a slight yellow-green tint. Indications: severe course of infectious pathology, as a radiosensitizing drug.

Metronidazole is a fairly popular antibacterial drug with diverse pharmacological effects, often prescribed in the complex treatment of various pathologies.

The bactericidal effect is due to the ability of the drug to affect the process of respiration of harmful anaerobic microorganisms and the synthesis of nucleic acids.

The drug is used in medical practice for the treatment of protozoal infectious diseases, diseases of the bones and joints of an infectious nature, infectious diseases of the abdominal cavity.

Clinical and pharmacological group

Antiprotozoal drug with antibacterial activity.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Metronidazole cost? The average price in pharmacies is at the level of 20 rubles.

Release form and composition

Metronidazole tablets have a white or white with a yellow-green tint color, a flat-cylindrical shape with a separating risk. The main active ingredient of the drug is metronidazole, its content in one tablet is 250 mg. It also includes auxiliary components:

• Talc.
• Potato starch.
• Stearic acid.

Metronidazole tablets are packaged in a blister of 10 and 20 pieces. A cardboard pack contains from 1 to 10 blisters with the appropriate number of tablets and instructions for using the drug.

Pharmacological effect

The antibacterial drug has a special mechanism of action, which consists in activating the biochemical reduction of the fifth nitro group with the help of intracellular transport proteins of the simplest and anaerobic mechanisms, as described in the instructions for use. The restored cells interact with the DNA of microorganisms, which is accompanied by inhibition of the synthesis of their nucleic acid. As a result, the immediate death of bacteria occurs.

The instruction of the antibacterial tablet preparation contains information that it is effective against gram-negative and some positive anaerobes. The minimum inhibitory concentration for the destruction of pathogenic microorganisms is considered to be a dose of 0.125-6.25 μg / ml. The antibiotic, together with amoxicillin, is active against Helicobacter pylori, since such a combination of drugs helps to suppress the development of resistance.

The drug "Metronidazole" is not active against aerobic microorganisms and facultative forms of anaerobes. It should be noted that in the presence of mixed flora, this drug acts synergistically with antibacterial agents that are effective against simple aerobes. Metronidazole has an effect on tumors, increasing their sensitivity to radiation. The drug has a disulfiram-like effect, causing sensitization to alcohol, and also turns out to be a stimulator of reparative processes.

Indications for use

What helps? Metronidazole is used in the following cases:

• with alcoholism;
• for and ;
• in infections caused by Bacteroides spp. (infections of the abdominal cavity, pelvic organs, infectious diseases of soft tissues and skin, abscess of the ovaries and fallopian tubes, infections of the vaginal fornix after surgery);
• with protozoal infections (intestinal or extraintestinal amoebiasis, balantidiasis, cutaneous leishmaniasis, trichomoniasis, trichomonas urethritis, giardiasis, trichomonas vaginitis);
• for the treatment of infectious diseases of the central nervous system, bones and joints, provoked by the activity of Bacteroides spp.;
• with pseudomembranous colitis associated with the use of antibiotics; for the prevention of postoperative complications during appendectomy, gynecological surgery, operations on the perirectal region.

Metronidazole suppositories are used to treat urogenital trichomoniasis and bacterial vaginitis caused by susceptible microorganisms.

Contraindications

• lactation period;
• leukopenia (including history);
• organic lesions of the central nervous system (including epilepsy);
• hypersensitivity to the composition of the drug Metronidazole, from which side effects may develop;
• liver failure (in the case of high doses);
• pregnancy (1 trimester).

Use during pregnancy and lactation

If it is necessary to prescribe Metronidazole to the mother, it is advisable to transfer the infant to artificial feeding.

Dosage and method of application

The instructions for use indicate that Metronidazole tablets are taken orally, during or after meals, (or washed down with milk), without chewing.

1. With giardiasis - 15 mg / kg / day in 3 divided doses for 5 days.
2. With giardiasis - 500 mg 2 times / day for 5-7 days. Children under 1 year old - 125 mg / day, 2-4 years old - but 250 mg / day, 5-8 years old - 375 mg / day, over 8 years old - 500 mg / day (in 2 divided doses). The course of treatment is 5 days.
3. In chronic amebiasis, the daily dose is 1.5 g in 3 divided doses for 5-10 days.
4. Adults: with asymptomatic amebiasis (if a cyst is detected), the daily dose is 1-1.5 g (500 mg 2-3 times / day) for 5-7 days.
5. In acute amoebic dysentery - 2.25 g in 3 doses until the symptoms stop.
6. With balantidiasis - 750 mg 3 times / day for 5-6 days.
7. With liver abscess - the maximum daily dose is 2.5 g in 1 or 2-3 doses, for 3-5 days, in combination with antibiotics (tetracyclines) and other methods of therapy. Children 1-3 years old - 1/4 adult dose, 3-7 years old - 1/3 adult dose, 7-10 years old - 1/2 adult dose.
8. With pseudomembranous colitis - 500 mg 3-4 times / day.
9. With ulcerative stomatitis, adults are prescribed 500 mg 2 times / day for 3-5 days; in this case, the drug is not indicated for children.
10. In the treatment of anaerobic infections, the maximum daily dose is 1.5-2 g.
11. In the treatment of chronic alcoholism, 500 mg / day is prescribed for a period of up to 6 (no more) months.
12. For the prevention of infectious complications - 750-1500 mg / day in 3 doses 3-4 days before surgery, or once 1 g on the 1st day after surgery. 1-2 days after the operation (when ingestion is already allowed) - 750 mg / day for 7 days.
13. For the eradication of Helicobacter pylori - 500 mg 3 times / day for 7 days (as part of combination therapy, for example, a combination with amoxicillin 2.25 g / day).
14. With trichomoniasis - 250 mg 2 times / day for 10 days or 400 mg 2 times / day for 5-8 days. Women need to additionally prescribe Metronidazole in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment or increase the dose to 0.75-1 g / day. Between courses, you should take a break of 3-4 weeks with repeated control laboratory tests. An alternative therapy regimen is the appointment of 2 g once to the patient and his sexual partner. Children 2-5 years old - 250 mg / day; 5-10 years - 250-375 mg / day, over 10 years - 500 mg / day. The daily dose should be divided into 2 doses. The course of treatment is 10 days.

With severe renal dysfunction (CC less than 10 ml / min), the daily dose should be halved.

Side effects

The drug has a number of side effects from many body systems.

1. On the part of digestion, vomiting, nausea, dry mouth, glossitis, pancreatitis can be observed.
2. On the part of the genitourinary system, there may be cystitis, candidiasis, urinary incontinence, urine staining.
3. The skin may experience urticaria, itching, hyperemia.
4. The nervous system can react with headache, insomnia, peripheral neuropathy, hallucinations, confusion, irritability, excitability, incoordination, ataxia, and depression.

All of the above signs are symptoms of intoxication, if they occur, you must immediately stop treatment, then rinse the stomach or skin and consult a doctor. Symptoms of giardiasis can appear with successful treatment of the pathology, they need to be rechecked every 3-4 days 3 times.

Overdose

If an overdose of the drug occurs, the patient may experience ataxia, nausea, and vomiting. In case of severe overdose, peripheral neuropathy and seizures may occur.

In this case, symptomatic therapy is practiced, there is no specific antidote.

special instructions

Before you start using the drug, read the special instructions:

1. Colors urine dark.
2. In combination with amoxicillin, it is not recommended for use in patients under 18 years of age.
3. With prolonged therapy, it is necessary to control the blood picture.
4. With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.
5. The appearance of ataxia, dizziness and any other deterioration in the neurological status of patients requires discontinuation of treatment.
6. May immobilize treponema and lead to a false positive Nelson test.
7. In the treatment of trichomonas vaginitis in women and trichomonas urethritis in men, it is necessary to refrain from sexual activity. Mandatory simultaneous treatment of sexual partners. Treatment does not stop during menstruation. After therapy for trichomoniasis, control tests should be carried out for three regular cycles before and after menstruation.
8. After treatment of giardiasis, if symptoms persist, perform 3 stool tests at intervals of several days after 3-4 weeks (in some successfully treated patients, lactose intolerance caused by invasion may persist for several weeks or months, resembling the symptoms of giardiasis).

Alcohol compatibility

During the treatment period, ethanol is contraindicated (possible development of a disulfiram-like reaction: spastic abdominal pain, nausea, vomiting, headache, sudden rush of blood to the face).

drug interaction

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Sulfonamides enhance the antimicrobial effect of metronidazole.
2. Enhances the effect of indirect anticoagulants, which leads to an increase in the time of formation of prothrombin.
3. Similar to disulfiram, it causes ethanol intolerance.
4. When taken simultaneously with lithium preparations, the concentration of the latter in plasma and the development of symptoms of intoxication may increase.
5. It is not recommended to combine with non-depolarizing muscle relaxants (vecuronium bromide).
6. Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in its concentration in the blood serum and an increase in the risk of side effects.
7. The simultaneous administration of drugs that stimulate microsomal oxidation enzymes in the liver (phenobarbital, phenytoin) can accelerate the elimination of metronidazole, resulting in a decrease in its plasma concentration.
8. Simultaneous use with disulfiram can lead to the development of various neurological symptoms (the interval between administration is at least 2 weeks).

Treatment of gynecological diseases caused by pathogenic microorganisms is always accompanied by antibiotics. A common drug is the antibiotic Metronidazole - instructions for use indicate that it is prescribed for the treatment of candidiasis, trichomoniasis, infectious diseases of the intestine and abdominal cavity, gastritis and ulcers caused by the pathogenic bacterium Helicobacter pylori. Doctors prescribe it in combination with drugs that restore microflora, because the antibiotic destroys not only pathogenic, but also the necessary microorganisms.

What is metronidazole

Medical therapy includes the use of antibiotics. Clinical and pharmacological group of Metronidazole - instructions for use indicate that it is an antiprotozoal drug, has an antibacterial and antiviral effect. It acts against many known bacteria, is used in gynecology, dermatology, gastroenterology and oncology for the treatment and prevention of pathologies caused by pathogenic microorganisms. The drug is a derivative of 5-nitroimidazole.

Composition and form of release

The table below shows the constituent components of the drug in accordance with the release form:

Release form

For different purposes, the drug is available in 4 forms:

• ploskotsilindrichesky tablets of a green or yellow shade;
• cream for external use;
• suppositories for intravaginal use;
• solution for injections (droppers) in 0.5% ampoules.

The above forms have a different composition and are recommended for use in various pathological situations. Tablets, cream, suppositories and Metronidazole solution have an antimicrobial effect. Solution in ampoules and tablets are often used in gastroenterology, suppositories - in gynecology, and ointment for the treatment of dermatological pathologies.

Pharmacodynamics and pharmacokinetics

The components of the drug interact with the DNA cells of microorganisms, inhibit the synthesis of nucleic acids and the metabolism of the substance - this leads to the death of pathogenic bacteria. The drug is active against bacterial strains such as gram-positive anaerobic infections. Metronidazole - instructions for use indicate that it is not effective against aerobic microorganisms, mixed flora of anaerobic bacteria and aerobes. Increases the sensitivity of tumors to radiation therapy, if the resistance of the tumor is explained by cell hypoxia.

Pharmacokinetics: has a high level of absorption and penetrating power. After ingestion, it reaches a bactericidal concentration. It is absorbed into the lungs, skin, kidneys, liver, brain, saliva, seminal fluid, bile, vaginal discharge, placental barrier, breast milk and amniotic fluid. Many oncologists also recommend taking Metronidazole - the instructions for use indicate that it increases the sensitivity of tumor cells to radiation exposure. The drug in the form of tablets and suppositories is partially absorbed, by 80%.

Indications for use

The drug has a wide spectrum of action and is recommended for the treatment of the following pathologies:

• trichomoniasis;
• acute and chronic amoebiasis;
• abscess of the lungs, liver;
• skin infections;
• pathologies that were provoked by anaerobic microorganisms;
• abscess of the ovaries and fallopian tubes after the intervention;
• infectious complications;
• pseudomembranous colitis;
• dysentery;
• sepsis;
• urethritis;
• pneumonia;
• alcoholism treatment;
• bone infections;
• meningitis;
• brain abscess;
• endocarditis.

How to take Metronidazole

The dosage of each form of the drug is prescribed by the doctor individually, depending on the diagnosis, the age of the patient and individual characteristics. Children from 2 to 12 years old are prescribed 45-50 mg per 1 kg of body weight 3 r / day for 10 days. For the treatment of giardiasis - 500 mg 2 times a day for a maximum of 7 days. Children under the age of 1 year, 125 mg per day 2 r / day for 5 days. Patients over 12 years of age and adults should take 250-500 mg 3 r / day for no more than 7-10 days. For the prevention of infectious diseases, for children and adults, a single dose should consist of 4 tablets.

Candles

For the treatment of gynecological infections, the drug Metronidazole - instructions for use for which indicates that it is prescribed in the form of vaginal tablets. When absorbed into the mucous membrane, the active components disrupt the structure of the DNA of pathogenic cells. Suppositories are active against Trichomonas, obligate microbes and others, but will not be able to eliminate aerobic bacteria. Vaginal suppositories are administered vaginally 1 piece at night. The course of treatment is 10 days, if necessary, it should be repeated after waiting an interval of 5-6 weeks.

Contraindications for use are pregnancy and breastfeeding. Vaginal suppositories should be inserted deep into the vagina after the washing procedure. If irritation, burning and other symptoms occur, you should consult a doctor and stop using the drug. After 7-8 hours after insertion, the suppository dissolves and may leak, to avoid leakage, it is recommended to use sanitary pads.

Metronidazole IV

This form of release of the drug is prescribed for the treatment of acute infectious bacterial diseases of the abdominal cavity, bones, joints, central nervous system, intestines, liver and kidneys. It is administered intravenously by infusion, for adults the first dose is 0.5-1 g, the next - 500 mg every 8 hours. The daily dose should not exceed 1 g. It should be used with caution during the 1st and 2nd trimesters of pregnancy and lactation.

Gel

It is actively used in dermatology for the treatment of acne, it is active against the Demodex mite, which lives in the hair follicles and sebaceous glands. Gel Metronidazole Nycomed should be applied in a thin layer to the affected, previously cleansed skin area twice a day - in the morning and at night. The duration of the course of treatment is from 1 to 5 months. When applying, avoid mucous membranes and the area near the eyes. Effective against acne, eczema, dermatitis, oily seborrhea, bedsores, anal fissures, trophic ulcers of the extremities.

Metronidazole tablets

The drug is taken orally after a meal, you can drink water or milk. Tablets have a greenish or yellowish tint and a flat-cylindrical shape. Adults: 1-1.5 g per day for 1 week. The duration of the course of therapy is 5 days. When treating trichomonas vaginitis, it is necessary to treat both partners at the same time. Doctors often prescribe this form of release for the treatment of many infectious diseases. Tablets are well tolerated by patients, side effects are rare.

special instructions

During treatment with Metronidazole, ethanol should not be taken - this can cause nausea, abdominal pain, vomiting and headache. The components of the composition of the drug contribute to the darkening of the urine. During the treatment of vaginitis and gynecological bacterial infections, one should refrain from sexual activity for the period of treatment, but continue it during the menstrual cycle. If any side effects appear, such as ataxia, headache, dizziness, you must stop taking the drug and consult a doctor.

Metronidazole for children

This drug is prescribed orally to patients from birth to 18 years of age in different dosages depending on the diagnosis and exact age. With giardiasis, children from 2 to 5 years old - 250 mg per day, up to 1 year old - 125 mg each, from 5 to 8 years old - 370 mg each, from 8 to 18 years old - 500 mg per day. With giardiasis, the daily dose is 45 mg, it should be divided by 15 mg into 3 doses for 5 days. With a liver abscess, the recommended dose for a child from 1 to 3 years old is 0.5 g per day, from 3 to 7 years old - 1 g, from 7 to 10 years old - 1.25 g. With ulcerative stomatitis, the drug is not prescribed for children.

drug interaction

There are several groups of drugs with which this medicine is not recommended to be combined:

• disulfiram - simultaneous administration contributes to the development of adverse neurological disorders;
• cimetidine - increases the concentration of metronidazole in the blood, increases the risk of side effects;
• phenytoin, phenobarbital lower its concentration in blood plasma;
• lithium preparations - provoke neurological symptoms against the background of intoxication;
• sulfonamides enhance the antimicrobial effect, indirect anticoagulants, have a positive effect when taken simultaneously.

Side effects

The drug has a number of side effects from many body systems. On the part of digestion, vomiting, nausea, dry mouth, glossitis, pancreatitis can be observed. The nervous system can react with headache, insomnia, peripheral neuropathy, hallucinations, confusion, irritability, excitability, incoordination, ataxia, and depression.

In addition to these symptoms, urticaria, itching, hyperemia can be observed on the skin. On the part of the genitourinary system, there may be cystitis, candidiasis, urinary incontinence, urine staining. All of the above signs are symptoms of intoxication, if they occur, you must immediately stop treatment, then rinse the stomach or skin and consult a doctor. Symptoms of giardiasis can appear with successful treatment of the pathology, they need to be rechecked every 3-4 days 3 times.

Contraindications

Before using this drug, you should consult a doctor who can determine the presence of contraindications. The use of Metronidazole Nycomed may be prohibited if the following signs are present:

• 1st trimester of pregnancy, with caution in the 2nd and 3rd trimester;
• individual intolerance:
• leukopenia;
• breastfeeding period;
• damage to the central nervous system of an organic type;
• liver failure;
• kidney failure;
• epilepsy.

Terms of sale and storage

The medicine can be bought in pharmacy chains only with a prescription. Information on the storage of Metronidazole - the instructions for use indicate that it should be stored only in dry rooms, isolated from light and direct sunlight, the storage temperature should not exceed 25 degrees. The shelf life of the drug is 2 years from the date of manufacture.

Analogues of Metronidazole

There are many alternative drugs on the market. Some of them:

Metronidazole price

The table below shows the difference in prices for different forms of release of an antibacterial drug in Moscow and the Moscow region. You can buy it in pharmacies or online through an online store. When buying a drug via the Internet, it is necessary to check the date of manufacture and the integrity of the package.

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