Oily solution of vitamin D3. Release form and packaging. Vitamin D - indications for use

For good health and normal well-being, a person must consume vitamins and other useful substances daily. Vitamin D, also called calciferol, enters the body with food and is also formed in the skin under the influence of solar radiation. Calciferol deficiency is diagnosed in adults and children who walk little under the sun, who eat poorly, as well as in residents of northern countries, where sunny days are rare. Doctors often prescribe liquid vitamin D to patients with severe hypovitaminosis. The dosage of the drug and the course of administration are determined by a medical specialist.

The benefits of vitamin D for the human body

Vitamin is involved in the metabolism of minerals, promotes the accumulation of calcium in bone and dental tissue. Also, calciferol is necessary to maintain the functioning of muscle fibers and the immune system. Without a vitamin, minerals cannot be absorbed in the intestines, they completely leave the body with urine. Vitamin D is important for the proper functioning of the heart muscle and thyroid gland, normalization of blood pressure and blood clotting. Even with a low content of a substance in the body, a person becomes susceptible to cardiovascular, dermatological, and oncological pathologies.

What is the difference between vitamins D 2 and D 3?

Ergocalciferol is vitamin D2 and cholecalciferol is vitamin D3. Ergocalciferol is present in the tissues of plant organisms. To get enough of it, you need to include fresh vegetables and fruits in the menu every day. In a small amount, the substance is found in dairy products and cereals. And cholecalciferol is produced in the skin under the influence of sunlight, and also enters the body with animal products.

Vitamin D 2 regulates the metabolism of calcium and phosphorus, activates the absorption of these minerals into the blood, and promotes their rapid delivery to bone tissue. Vitamin D 3 stimulates the absorption of minerals in the small intestine, ensures the transport of absorbed substances throughout the body. In the human body, cholecalciferol is converted to calcitriol, an active compound that fights malignant cells.

Ergocalciferol in the human body is broken down into several compounds that, in excess, can harm organs and systems. Therefore, when using medicines based on vitamin D, you must carefully follow the instructions to avoid overdose. Before taking liquid calciferol, it is advisable to consult a doctor.

The consequences of a lack of vitamin D in the human body

It is important that the concentration of calciferol in the body remains normal. Vitamin deficiency leads to extremely negative consequences. Hypovitaminosis is especially dangerous for the body of young children and pregnant women. The child's body is actively growing and developing, therefore, it needs a large amount of useful substances. And with a lack of a vitamin, the development of the child is inhibited. A pronounced deficiency of calciferol in children leads to the occurrence of rickets and other pathologies of the musculoskeletal system.

Rickets, caused by a lack of vitamin D in the body, is diagnosed in people who are at home or at work all day, rarely go out into the sun, and live in the northern regions. Calciferol deficiency in an adult is accompanied by the following symptoms:

• chronic fatigue;
• lethargy, weakness, poor health;
• decrease in working capacity;
• slow healing of fractures;
• low bone mineralization.

In a child, vitamin deficiency is manifested by more pronounced symptoms:

• curvature of the legs;
• deformation of the chest and pelvic bones;
• incorrect formation of the face and head, flattening of the back of the head;
• low bone density;
• excessive sweating;
• irritability, capriciousness, sleep disturbance;
• late teething.

All of the above symptoms in a child signal the development of rickets.

Daily intake of vitamin D for adults and children

People who, for whatever reason, are deficient in calciferol, need to take drugs based on vitamin D 3. But when taking medications, it should be remembered that an excess of calciferol is just as harmful to the body as a deficiency. To avoid health problems, the vitamin must be consumed in accordance with the instructions for use. The daily intake of the drug is determined by the age, physical condition, well-being, living conditions of the patient. But usually the dosages look like this:

• a healthy adult needs no more than 600 IU of a substance per day;
• child, depending on age - at least 400 - 500 IU;
• a pregnant woman - about 800 IU.

Women who are carrying a child must definitely take vitamin D supplements. This will avoid exhaustion of the mother's body, the occurrence of malformations of the embryo. Also, calciferol in a liquid dosage form is indicated as part of general strengthening therapy for the elderly and in poor health.

Liquid dosage forms of vitamin D

Pharmacies sell a huge number of vitamin D preparations from different manufacturers. Popular and effective dosage forms are:

• aqueous solution for oral administration;
• oily solution for oral administration;
• injection.

Once in the digestive tract, liquid vitamin D is absorbed through bile in the small intestine. The digestibility of the aqueous solution is higher than that of the oil preparation.

In the treatment of frail and premature infants, it is better to use an aqueous solution. The fact is that in weak babies, not enough bile is synthesized in the body to process the vitamin dissolved in oil.

The best vitamin D preparations for adults and children

For children, many calciferol preparations are available with a dosage of 400 IU.

1. ChildLife Organic Vitamin D 3 Drops. Cholecalciferol in drip form with berry flavor. Suitable for babies from birth.
2. Nordic Naturals Baby's Vitamin D3. A vitamin dissolved in olive oil without artificial components.
3. Natural Factors Vitamin D3. Cholecalciferol dissolved in linseed oil.
4. Baby Ddrops Liquid Vitamin D 3 . It is the name of the most popular infant drug in the US and has received numerous medical awards.

For adults, calciferol preparations are offered with a dosage of 1000 IU.

1. Nordic Naturals Vitamin D 3 Vegan. A product for strict vegetarians. Based on calciferol isolated from lichens.
2. Carlson Labs Super Daily D3. Liquid vitamin for adults. Does not contain artificial components.
3. Garden of Life MyKind Organics Vegan D 3 Vanilla Spray. Cholecalciferol for vegans, isolated from lichens, sold in the form of a spray.
4. Dr. Mercola Premium Supplements Sunshine Mist Vitamin D. High quality spray formulation.

Indications and contraindications for use

Liquid vitamin D is prescribed to people with the following pathologies and characteristics of the body:

• rickets;
• osteoporosis;
• hypovitaminosis;
• violation of the liver;
• sudden weight loss, exhaustion;
• diseases of the digestive tract;
• pregnancy and breastfeeding;
• rehabilitation after surgery;
• poor diet, including vegetarian.

It is forbidden to take calciferol in the following cases:

• with hypervitaminosis D;
• with renal failure;
• when sensitive to a substance.

Pregnant women and young children should take calciferol carefully, carefully following the instructions and medical recommendations.

With an overdose of the vitamin and the development of hypervitaminosis D, the following symptoms are observed:

• headache;
• allergic reaction;
• loss of appetite;
• nausea;
• constipation;
• thirst;
• increased blood pressure;
• arrhythmia;
• weakness;
• photophobia;
• drying of mucous membranes;
• metallic taste on the tongue.

If the above symptoms occur, you should immediately stop taking the drug.

Features of taking liquid vitamin D by pregnant women and children

Calciferol, dissolved in oil, is prescribed for both prophylactic and therapeutic purposes. Which drug to take for the patient, the medical specialist decides, he also determines the dosage and course of treatment.

At the 30th week of gestation, a woman is prescribed 1400 IU of the vitamin. The drug should be taken before childbirth every three days. This is important to prevent rickets in a newborn baby. If a woman did not take a vitamin during pregnancy, then she must do this during breastfeeding. If a newborn baby is sick with rickets, then he is prescribed, based on the severity of the disease, from 7 to 24 drops of vitamin per day.

One drop of the oil solution contains 600 IU of the substance. An oil-based preparation is recommended for young children during the winter months to prevent rickets. In the summer, you do not need to use the medication if the child often walks outside under the sun. A water-based vitamin is recommended for both adults and children from three weeks of age. The dosage is set by the doctor, but it can be up to 20 drops per day.

Getting acquainted with the prices of vitamin D preparations (including oil-based products from Finland)

Among vitamin D preparations, there are both very expensive and quite affordable means. In many cases, the price of vitamin D does not reflect the quality of a particular product, but is formed on the basis of the cost of its production in a specific form of release and the cost of implementation.

A lot also depends on the brand: drugs from well-known European pharmaceutical concerns (Finnish vitamin D from several manufacturers is the most famous here) usually turn out to be much more expensive than domestic products with similar characteristics.

In addition, the price is determined by the presence of certain additional properties and activity of the drug. For example, a simple oil-based vitamin D is in most cases much cheaper than a calcium and phosphorus supplement that provides comprehensive support for bone and cartilage.

The price also depends on the form of release of the drug. It could be:

• oil solution of vitamin D in large packaging
• vitamin D drops
• vitamin D capsules
• solutions for intramuscular injections (often identical in composition to a simple oil solution)
• dragees and tablets
• as well as multivitamins containing vitamin D.

And finally, the price of vitamin D depends on the chemical form of the vitamin itself present in the preparation. So, products with vitamin D3 are on average more expensive than analogues with D2 and, moreover, with synthetic substitutes with a similar effect.

Most often, vitamin D preparations include vitamin D3 as its most easily digestible and natural form. It is D3 that is optimally suited for children and has the fastest effect on a particular organ system.

Thus, for example, Finnish vitamin D3, used in the prevention and treatment of a large number of diseases, will be much more expensive than a simple oil solution of vitamin D. But at the same time, in some cases, for example, in the prevention of rickets, the latter is as widely applicable and effective as its imported counterpart.

Now let's see how much specific drugs cost in Russian pharmacies.

Aquadetrim is one of the most popular vitamin D preparations for children. It is prescribed for newborns and premature infants, children of all ages and adolescents.

The daily rate of the active substance is contained in one drop of Aquadetrim. Vitamin D is presented in the preparation in the form of D3, and due to the water base, the preparation is much easier to digest and exhibits fewer side effects.

The manufacturer of the drug is the Polish Medana Pharma.

The price of Aquadetrim is approximately 350 rubles per 10 ml bottle. The drug is sold both through conventional pharmacies and through online stores.

Fish oil is available in the form of a solution and capsules, and cod liver oil is usually used for the manufacture. The drug is given to school-age children and adults.

A 100 ml bottle of fish oil costs about 100 rubles, and capsules with a total fat content of 1000 mg cost about 450 rubles.

Vigantol is an analogue of Aquadetrim, but is produced in Germany by Merck KGaA and has an oil base. Its cost is about 650 rubles for a 10-ml bottle.

Alpha D3-Teva is an oily solution of vitamin D3 in gelatin capsules. It contains not natural vitamin D3, but its synthetic analogue, which has an identical effect.

The cost of the drug is about 300 rubles per pack of 30 capsules.

Finnish Vitamin D3 Devisol is an oily solution of natural D3. Its base is coconut oil. With virtually no additives, this vitamin D from Finland is suitable for both adults and children, including newborns to prevent rickets and preterm infants to support skeletal development.

The cost of Devisol in a 10 ml bottle is approximately 550 rubles. The drug is widely available in online pharmacies.

The drug is available in the form of tablets. They should be consumed without chewing, swallowing whole before meals or during meals. Vitrum Calcium + vitamin D3 is intended primarily for the prevention of osteoporosis. For this purpose, it is recommended to use 1 tablet 2 times a day.

The price of Vitrum Calcium + D3 is about 400 rubles per pack of 60 tablets.

Calcium D3 Forte is produced by Nycomed and is intended for the prevention of osteoporosis and the fight against calcium deficiency in the body. The drug prevents the production of parathyroid hormone, which contributes to the leaching of calcium from the bones, and also supplies the body with calcium itself.

The price of the drug depends on the number of capsules in the vial. 20 capsules cost an average of 150 rubles, and 100 capsules - about 500 rubles.

Vitrum Osteomag is a complex drug designed for the prevention and treatment of osteoporosis, as well as recovery from fractures. Contains calcium, vitamin D3, magnesium, copper, zinc, boron, is available in the form of tablets coated with a smooth shell.

The cost of the drug is approximately 500 rubles per pack of 60 tablets.

The drug Tevabon is intended for intensive therapy of osteoporosis, is available in the form of gelatin capsules and tablets (one package contains 4 tablets and 28 capsules), its active substance is alfacalcidol, a synthetic analogue of vitamin D.

The drug has a large number of side effects and is not recommended for use by children, pregnant and lactating mothers.

The cost of Tevabon is approximately 2800 rubles per pack.

Van-Alfa is a preparation of alfacalcidol (a synthetic analogue of vitamin D3) in tablets. Designed to combat rickets in children, as well as to support immunity and regulate the thyroid gland.

The price of Van Alfa is about 300 rubles for a pack of 20 tablets.

D3 BON - an oily solution of vitamin D3, intended for oral and intramuscular injections. Ideal as a source of vitamin D3 for infants, it can be used as an alternative to Aquadetrim. D3 BON contains olive oil as a solvent. It is not recommended to take the drug during pregnancy.

D3 BON is produced in France by Pharma-Livron.

The price of an oil solution D3 BON is about 1700 rubles for five 1 ml bottles.

Etalfa is a vitamin D3 preparation, which is a solution of alfacalcidol in sesame oil with the addition of biologically active substances. The drug is produced in Denmark and costs about 200 rubles.

With the use of multivitamins, one should be careful, since there is a risk of developing hypervitaminosis for any vitamin when trying to adjust the amount of vitamin D with their help.

The price of preparations containing vitamin D varies, for example, from 300 to 50 rubles for a package of various Alphavit preparations, from 400 to 650 rubles for a package of Complivit vitamins, from 750 to 4000 rubles for a package of Merz vitamins.

You should never choose a vitamin preparation only on price. First of all, you need to focus on the doctor's recommendation, indications for use and the safety of a particular remedy. And only when choosing from two analogues, you can prefer the one that will save a little money.

Source:
Getting acquainted with the prices of vitamin D preparations (including oil-based products from Finland)
A review of prices for vitamin D preparations in various forms of release, including oil-based ones from Finland.
http://www.vitaminius.ru/vitamin-d/cena-na-vitamin-d.php

Structure and physico-chemical properties of vitamin D

The rest of the D vitamins and related 7-dehydrocholesterol, ergosterol and other substances also quite easily add oxygen to form peroxide compounds. The latter are crystals that are sufficiently stable when heated; they are easily isomerized into eponxide compounds and into ketones under the action of heat and light (Karnozhitsky, 1961).

For a long time, it was believed that lumisterin, one of the precursors of vitamin D, did not have antirachitic activity. However, studies in recent years have shown a high activity of this drug in the prevention of rickets in chickens.

Until now, the antirachitic activity of vitamins D4, D5, D7 has not been sufficiently studied. According to H. F. De Luca (1967), vitamin D4 has only half the activity of vitamin D3. Vitamin D7 was first isolated from cod liver oil, tuna, shark (Raoul, 1958). Later, it was found in the liver of many fish, milk and various plants. Due to the strong absorption in the region of 250 mk, this compound was named ketone 250. In a biological study, it was found that ketone 250 has 1/10 of the antirachitic activity of vitamin D2. However, its derivative is Ca enolate, which is equal in activity to vitamin D2. L. Fizer and M. Fizer (1964) argue that the formation of ketone 250 from vitamin D3 in the body is possible. However, this has not yet been proven.

As you know, vitamins D2 and D3 have the greatest biological activity. However, the literature data are very contradictory. N. F. De Luca (1967) in studies with labeled C14-vitamin D2 and 1,2H3-vitamin D3 received an approximately equal antirachitic effect. R. D. Hunt, F. G. Garcia, (1967), studying the effect of vitamins D2 and D3 on Ca45 absorption in primates, found that cholecalciferol (D3) is more active than ergocalciferol (D2). At present, most researchers adhere to this point of view (Petrova, Bogoslovsky, 1970, etc.). The activity of vitamin D preparations is expressed in international units (ME); 1 IU contains 0.000025 mg (0.025 mcg) of chemically pure vitamin D.

In recent years, the Institute of Biochemistry of the Academy of Medical Sciences of the Ukrainian SSR (Prof. V. P. Wendt) has proposed a protein complex of vitamins D2 and D3 - videin. 1 g of the drug contains 200,000 IU. However, industrial production of videin has not yet been established. When using this drug for the prevention and treatment of rickets, we did not notice a significant advantage over alcohol and oil solutions of vitamin D2. In addition, in our opinion, videin is offered in a very high concentration, which should be reduced in the case of its industrial production.

Vitamin D preparations, including fish oil, must be stored in conditions that exclude the action of light and air, leading to inactivation of these medicines. As already mentioned, atmospheric oxygen oxidizes vitamin D, and light turns it into poisonous toxisterol. In this regard, vitamin D and its preparations are stored with caution (list B). Dragees of ergocalciferol are stored in a dry, dark place, alcohol and oil solutions - in top filled, well-packed orange glass bottles, in a place protected from light, at a temperature not exceeding 10 °.

In the body of an infant, it causes a violation of the metabolism of calcium and phosphorus. As a result, skeletal ossification occurs incorrectly, which eventually leads to rickets.

Vitamin D deficiency is critical for infants under one year of age. Their bones grow the fastest, and violations of mineral metabolism lead to serious consequences. For the prevention and treatment of rickets, children are given vitamin D preparations, which are on the market in several pharmaceutical forms.

Most often used aquatic or oil solutions. They begin to be used from the 2nd month of life for full-term babies, and from the 2-3rd week for premature babies.

Vitamin D for babies - which is better

Vitamin D3 oil solution for newborns

Advantages

• neutral taste;
• less likely to cause allergies;
• contains no alcohol;
• oil increases the bioavailability of vitamin D.

Flaws

• poorly absorbed in case of problems with the synthesis and secretion of bile;
• high risk of overdose if used incorrectly;
• short therapeutic effect (up to 1.5 months).

Aqueous solution of vitamin D3 for newborns

Advantages

• well absorbed in liver diseases;
• blood concentration increases 6-7 times faster than when using oil solutions;
• the therapeutic effect lasts up to 3 months;
• less likely to cause an overdose.

Flaws

• more likely to cause allergies;
• specific taste;
• contains alcohol.

An aqueous solution of vitamin D for infants is better and safer to use, but should be given with caution to children with allergies and alcohol intolerance. The oil solution is suitable for allergy sufferers, but its use requires accurate dose selection and the absence of liver disease.

In what preparations is vitamin D produced for newborns

Water based

1. Aquadetrim - produced in Poland, available in bottles of 10 ml. It is sold without a prescription, the average price is 145 UAH / 410 rubles.
2. Vitamin D3 aqueous solution - produced in Russia, available in bottles of 10 ml. It is sold without a prescription, the average price is 45 UAH / 115 rubles.

Oil based

1. Vigantol- German drug, 10 ml bottles, without a prescription, price 91 UAH / 280 rubles.
2. Devisol- Finnish vitamin D for newborns, 10 ml bottles, without a prescription, price 140 UAH / 400 rubles.
3. Vitamin D3 Bon- produced in France, ampoules of 1 ml, without a prescription, price 27 UAH / 130 rubles.

How to give vitamin D to a baby

There are several criteria that affect how infants should take vitamin D.
Type of feeding- almost all artificial mixtures contain vitamin D, when using them, dose adjustment or complete withdrawal of the drug is necessary. Children who eat natural milk are more likely to be deficient in vitamin D.

Health status- children with liver disease with impaired synthesis or outflow of bile should be given an aqueous solution of vitamin D. Allergic people should be given it with caution. In case of violation of absorption from the intestine, the dosage must be adjusted.

day length- the need for vitamin D increases in the autumn-winter period. In the conditions of the Far North, dosages increase regardless of the season.

A solution of vitamin D is given orally, after dissolving the required dose in a small amount of water. You can not drip the drug directly into the child's mouth - it is more difficult to measure the required amount, which often leads to an overdose.

Vitamin D deficiency in infants - symptoms

a lack of

• restless sleep;
• irritability and tearfulness;
• convulsions;
• excessive softness of the edges of a large fontanel;
• constipation;
• increased sweating;
• hair loss at the back of the head;
• an increase in the size of the head;
• flattening of the neck;
• softening of the bones of the crown;
• thickenings on the ribs in the form of a rosary;
• curvature of the bones of the legs;
• slow weight gain.

Vitamin D overdose in infants - symptoms

The main cause of hypervitaminosis D in infants is the wrong dosage. A single overdose rarely causes harm, more often it occurs with regular intake of large amounts of vitamin D.
Overdose

• thirst;
• frequent urination;
• deterioration in hair growth;
• anxiety;
• frequent regurgitation;
• diarrhea;
• constipation;
• labored breathing;
• convulsions;
• increase in blood pressure.

Allergy to vitamin D in infants

Allergy directly to vitamin D in children is rare. More often the body reacts to additional components that make up the drug.

The main symptoms of allergies in infants

1. rash on cheeks;
2. itching and peeling of the skin;
3. local inflammation of the skin;
4. eczema;
5. swelling of the tongue and lips;
6. angioedema;
7. sneezing and coughing;
8. asthma attacks.

Should You Give Vitamin D to Babies?

Doctors are divided on the importance of taking vitamin D. Some pediatricians believe that vitamin therapy is necessary for most infants, others argue that vitamin D should only be given to babies at risk. It includes children who are breastfed and living in regions with short daylight hours.

If the child does not have direct indications for taking vitamin D, then the final choice is made by the parents. Most pediatricians agreed that if the baby does not have side effects, then the use of the drug is advisable. In this case, the supposed benefit of using vitamin D outweighs the potential harm.

Most of the reviews about vitamin D for babies are positive. Allergic reactions are rare, other side effects are very rare. In children with symptoms of rickets, there is an improvement in the condition up to a complete recovery. Some parents report anxiety when using an aqueous solution of vitamin D, apparently associated with the alcohol that is part of the drug.
https://www.youtube.com/watch?v=vNQe9WevLpA

Instructions for medical use of the drug Akvadetrim vitamin D3

Tradename

Aquadetrim vitamin D3

International non-proprietary name

Colecalciferol

Dosage form

Drops for oral administration 15,000 IU/ml

Compound

1 ml solution (30 drops) contains

active substance - cholecalciferol 15,000 IU,

excipients: macrogol glyceryl ricinoleate, sucrose (250 mg), sodium hydrogen phosphate dodecahydrate, citric acid monohydrate, anise flavor, benzyl alcohol (15 mg), purified water.

Description

Colorless, transparent or slightly opalescent liquid with an aniseed odour.

Pharmacotherapeutic group

Vitamins. Vitamin D and its derivatives.

ATC code А11СС 05

Pharmacological properties

Pharmacokinetics

An aqueous solution of vitamin D3 is better absorbed than an oil solution (which is important when used in preterm infants). After oral administration, cholecalciferol absorption occurs in the small intestine by passive diffusion from 50 to 80% of the dose.

Absorption - fast (in the distal small intestine), enters the lymphatic system, enters the liver and into the general circulation. In the blood, it binds to alpha2-globulins and partially to albumins. Accumulates in the liver, bones, skeletal muscles, kidneys, adrenal glands, myocardium, adipose tissue. TCmax (period of maximum concentration) in tissues is 4-5 hours, then the concentration of the drug decreases slightly, remaining at a constant level for a long time. In the form of polar metabolites, it is localized mainly in the membranes of cells and microsomes, mitochondria and nuclei. Penetrates through the placental barrier, excreted in breast milk.

Deposited in the liver.

It is metabolized in the liver and kidneys: in the liver it turns into an inactive metabolite calcifediol (25-dihydrocholecalciferol), in the kidneys it turns from calcifediol into an active metabolite calcitriol (1,25-dihydroxycholecalciferol) and an inactive metabolite 24,25-dihydroxycholecalciferol. It undergoes enterohepatic recirculation.

Vitamin D and its metabolites are excreted in the bile, a small amount - by the kidneys. Cumulates.

Pharmacodynamics

Aquadetrim vitamin D3 is an anti-rachitic drug. The most important function of Aquadetrim vitamin D3 is the regulation of calcium and phosphate metabolism, which promotes mineralization and skeletal growth. Vitamin D3 is the natural form of vitamin D, which is produced in the human skin by exposure to sunlight. It plays a significant role in the absorption of calcium and phosphate from the intestine, in the transport of mineral salts and in the process of bone calcification, and also regulates the reabsorption of calcium and phosphate by the kidneys. Calcium ions are involved in a number of important biochemical processes that determine the maintenance of skeletal muscle tone, in the conduction of nervous excitation, and in the process of blood clotting. Aquadetrim vitamin D3 stimulates the production of lymphokines.

Indications for use of the drug Aquadetrim vitamin D3

Prevention and treatment:

Hypo- and avitaminosis of vitamin D (conditions of increased body demand for vitamin D in nephrogenic osteopathy, malnutrition and unbalanced nutrition, malabsorption syndrome, insufficient insolation, hypocalcemia, hypophosphatemia, renal failure, cirrhosis of the liver, pregnancy and lactation)

Hypocalcemic tetany

Osteomalacia and bone diseases with metabolic disorders (hypoparathyroidism and pseudohypoparathyroidism)

As part of complex therapy

Osteoporosis in postmenopausal women

Rickets-like diseases

Dosage and administration of Aquadetrim vitamin D3

The drug is taken orally with a small amount of liquid

1 drop contains about 500 IU of vitamin D3.

Prophylactic doses of Aquadetrim vitamin D3:

full-term newborns from 4 weeks of life to 2-3 years of life with proper care and sufficient exposure to fresh air - 500 IU (1 drop) per day;

premature newborns from 4 weeks of age, as well as twins, babies in poor living conditions - 1000 IU (2 drops) per day for one year. In the summer, you can limit the dose to 500 IU (1 drop) per day. The duration of therapy is up to 2-3 years of life;

pregnant women - a daily dose of 500 IU of vitamin D3 for the entire period of pregnancy, or 1000 IU / day from 28 weeks of pregnancy;

women in the postmenopausal period - 500 - 1000 IU (1-2 drops) per day, for 2-3 years, the doctor decides on the need for repeated courses of therapy.

Therapeutic doses of Aquadetrim vitamin D3:

for rickets, start with 2000 IU for 3-5 days, then, if well tolerated, increase the dose to an individual therapeutic dose of 2000-5000 IU (4-10 drops) daily, most often 3000 IU, depending on the severity of rickets (I, II , or III) and the variant of the course, for 4-6 weeks, under careful monitoring of the clinical condition and the study of biochemical parameters (calcium, phosphorus, alkaline phosphatase) of blood and urine. A dose of 5000 IU is prescribed only with pronounced bone changes.

As needed, after one week break, you can repeat the course of treatment. Treatment is carried out until a clear therapeutic effect is obtained, followed by a transition to a prophylactic dose of 500 - 1500 IU / day. The duration of the course of treatment and prevention is determined by the doctor;

with rickets-like diseases 10,000 - 20,000 IU per day (20 - 40 drops), depending on age, weight and severity of the disease, under the control of blood biochemical parameters and urinalysis. The course of treatment is 4-6 weeks. The doctor decides on the need for repeated courses of therapy;

with osteomalacia and postmenopausal osteoporosis as part of complex therapy 500 - 1000 IU (1-2 drops) per day.

The dosage, as a rule, is prescribed taking into account the amount of vitamin D that comes from other foods.

Side effects of the drug Akvadetrim vitamin D3

In the case of rarely noted individual hypersensitivity to vitamin D3 or as a result of the use of too high doses for a long period, hypervitaminosis D3 may occur:

Psychiatric disorders, including depression

Loss of appetite, nausea, vomiting, dry mouth, constipation

Head, muscle and joint pain

Weight loss

Polyuria

Increased calcium levels in the blood and urine

Kidney stone formation and soft tissue calcification

Contraindications to Aquadetrim vitamin D3

Hypersensitivity to the components of the drug, especially to benzyl alcohol

Hypervitaminosis D

Liver and kidney failure

Elevated levels of calcium and phosphorus in the blood and urine

calcium kidney stones

Sarcoidosis

Neonatal period up to 4 weeks

Drug Interactions

Antiepileptic drugs, rifampicin, cholestyramine, reduce the reabsorption of vitamin D3.

The use simultaneously with thiazide diuretics increases the risk of hypercalcemia.

Simultaneous use with cardiac glycosides may enhance their toxic effect (increased risk of manifestations of cardiac arrhythmias).

The toxic effect is weakened by vitamin A, tocopherol, ascorbic acid, pantothenic acid, thiamine, riboflavin.
Under the influence of barbiturates (including phenobarbital), phenytoin and primidone, the need for colecalciferol can increase significantly (increase the metabolic rate).
Long-term therapy against the background of the simultaneous use of aluminum and magnesium-containing antacids increases their concentration in the blood and the risk of intoxication (especially in the presence of chronic renal failure).
Calcitonin, derivatives of etidronic and pamidronic acids, plicamycin, gallium nitrate and glucocorticosteroids reduce the effect.
Colestyramine, colestipol and mineral oils reduce the absorption of fat-soluble vitamins from the gastrointestinal tract and require an increase in their dosage.
Increases the absorption of phosphorus-containing drugs and the risk of hyperphosphatemia. When used simultaneously with sodium fluoride, the interval between doses should be at least 2 hours; with oral forms of tetracyclines - at least 3 hours.
Simultaneous use with other analogs of vitamin D increases the risk of developing hypervitaminosis.

special instructions

Avoid overdose with Aquadetrim vitamin D3.

Individual provision of a specific need should take into account all possible sources of this vitamin.

Too high doses of vitamin D3, used for a long time or loading doses, can be the cause of chronic hypervitaminosis D3.

Determination of the child's daily requirement for vitamin D and the method of its use should be established by the doctor individually and each time subjected to correction during periodic examinations, especially in the first months of life.

Use with caution in immobilized patients.

Do not use calcium preparations in high doses simultaneously with vitamin D3.

Treatment is carried out under periodic monitoring of the level of calcium and phosphorus in the blood and urine.

Care must be taken when prescribing the drug to elderly people, since in this category of people calcium deposition in the lungs, kidneys and blood vessels increases.

Use with caution in patients with diabetes mellitus.

The period of pregnancy and lactation

During pregnancy, Vitamin D3 should not be used in high doses of 2,000 IU due to the possibility of a teratogenic effect in case of an overdose.

Caution should be given to Vitamin D3 during lactation, as the drug, taken in high doses by the mother, can cause overdose symptoms in the child.

Features of the effect of the drug on the ability to drive

vehicle or potentially dangerous machinery

Does not affect

Overdose of Aquadetrim vitamin D3

Symptoms: anxiety, thirst, loss of appetite, nausea, vomiting, diarrhea, constipation, intestinal colic, polyuria. Common symptoms are headache, muscle and joint pain, mental disorders, including depression, stupor, ataxia, and progressive weight loss. Kidney dysfunction develops with albinuria, erythrocyturia and polyuria, increased loss of potassium, hypostenuria, nocturia and increased blood pressure. In severe cases, clouding of the cornea may occur, less often swelling of the papilla of the optic nerve, inflammation of the iris up to the development of cataracts. Kidney stones may form, and soft tissue calcification occurs, including blood vessels, the heart, lungs, and skin. Rarely develops cholestatic jaundice.

Treatment: withdrawal of the drug, drinking plenty of fluids, symptomatic therapy.

Release form and packaging

10 ml in a dark glass bottle with a polyethylene stopper-dropper and a polyethylene screw cap with a “first opening” guarantee ring, together with instructions for medical use, in a cardboard box.

Storage conditions

To store in the place protected from light at a temperature from 5 °C to 25 °C. Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Holiday conditions

Without recipe

Manufacturer

Medana Pharma JSC

98-200 Sieradz, st. V. Loketka 10, Poland