When is the best time to take medications or each medication has its own time. Biological timing of medication

When we try to stick to our chosen diet, we pay a lot of attention to what we eat. But at the same time, we absolutely do not think about when exactly it is better to sit down at the dinner table, how many times during the day we should eat and what will happen if we decide tightly.

The standard number of meals per day is three. And that's if you're lucky. Some mistakenly believe that if they stop eating altogether or limit their meals to once a day, they will lose weight twice as fast. But usually such experiments lead to nothing but stress and health problems.

It is advisable to eat every 3-4 hours. This allows you to improve fat burning, prevents the release of an excess of insulin into the blood, allows leptin (the hormone that regulates energy metabolism) to work its magic and control appetite and metabolism. It also keeps the production of cortisol, the stress hormone, under control.

Don't skip breakfast! Our grandmothers were right when they said that the day should start with a good hearty breakfast. It gives energy to start a long productive day. If you skip breakfast, very soon the feeling of hunger takes you by surprise and you begin to interrupt the feeling of hunger with everything that comes to hand. And in offices, sweets and cookies are usually on hand.

Don't eat three hours before bed. Eating before bed increases body temperature, increases blood sugar and insulin levels, and reduces the production of melatonin and growth hormone. All of these factors affect sleep and the natural fat burning that occurs when we sleep. In addition, poor sleep leads to the fact that we can overeat the next day.

If it so happens that you have time to eat before bed, it is advisable to eat light meals with a low content and a high content.

Start your day with proteins. To improve appetite control, it is better to eat proteins for breakfast, and leave carbohydrates for lunch or dinner. Tomato omelette is a great quick breakfast!

Never start strength training on an empty stomach. For such activities, your body needs energy for optimal results. But cardio can be done 30 minutes before meals.

This does not mean that you need to fill up right before training. Just do not start classes if you have not eaten anything for a long time and you have a feeling of hunger. Before the workout itself, you can have a snack with bananas, nuts or dried fruits - high in calories, quickly absorbed, gives the necessary energy and relieves hunger.

Focus on food. While eating, it is undesirable to be distracted by something that does not concern your lunch. Focus on the main occupation, feel all the shades of taste, relax, finally, and rest. Your lunch is an island of peace and tranquility in the midst of the stormy ocean of the working day.

Squirrels go first. During meals, eat protein foods first, and then everything else. Proteins send a signal to your brain that your body is full. This way you will eat exactly as much as you need.

Take alcohol after meals. If you decide to have a drink at dinner or any other drink, it is better to do it after you have eaten, and not during. Alcohol after meals increases the production of hormones that control appetite and digestion.

And if you decide to drink white wine in the evening, keep in mind that it increases your appetite and the chance that you will want to have a snack is very high.

What time of day is best to take vitamins?

It is best to take vitamins in the morning or afternoon. On an empty stomach, vitamins should never be taken - only after meals. And in the evening they are not taken, as they may contain vitamin C, which has an exciting effect on the nervous system. And sleep can be disturbed.

I take vitamins in the morning, right after breakfast. During the day I may not be at home, but carrying a package of vitamins with me is somehow not for me, besides, I can get distracted and forget about them altogether. And at night you can drink them, correctly wrote one of those who have already answered your question, but after all, the body needs to rest, and not to digest and assimilate vitamins (the same applies to food before bedtime).

I drink vitamins in one tablet, I once bought vitamins - 3 tablets of different colors (morning, afternoon, evening). It was written on the package that such a fractional intake of vitamins contributes to their better absorption by as much as 30 percent. But then again, I often forgot to drink them. Therefore, it is easier for me to take one tablet in the morning.

In order for vitamins to be absorbed, they must be paired with minerals and trace elements. Balanced organic vitamin-micronutrient formulas with a phytosome or liposomal delivery method to the body are best taken 2-3 times a day. If a person has an excellent enzyme system, normal or increased acidity of gastric juice, then it is better to take them before meals. With insufficient production of enzymes and with low acidity of the stomach, it is better to take vitamins after meals, at the time of active digestion. If the complex is with essential amino acids, then for the purpose of losing weight, or with the desire to increase growth, it is good to take the drug at bedtime. In a dream, recovery processes occur, and we also give food to the pituitary gland, a growth hormone. We are talking about organic formulas, it is advisable not to take synthetic vitamins at all. These are antigens.

I myself take any vitamins or other tablets in the morning, at breakfast. It’s more convenient for me - during the day I can run and forget about vitamins - that’s how it was when I bought a multivitamin consisting of 3 parts - they had to be taken in the morning, afternoon and evening. At best, I took it in the morning and evening, at worst - only in the morning.

It is correct to take vitamins as indicated in the instructions for them. It is desirable that we take vitamins (do not forget that any multivitamin is a dietary supplement, i.e. a biologically active food supplement) along with other food, then the digestibility of the elements will be much higher.

Vitamins are best taken after meals with a glass of water.

By taking vitamins after breakfast, we will provide the body with a boost of energy during the day. Separate trace elements can be taken in the afternoon - then they are best absorbed.

In the evening, you can take B vitamins, magnesium preparations. They calm the nervous system and promote good healthy sleep.

It is best to take vitamins, of course, in the morning on an empty stomach, as they give you a charge for the whole day and are spent throughout the day. Naturally, before you start taking vitamins, you need to consult a doctor or at least ask at a pharmacy. Also, we must not forget about the natural vitamins in vegetables and fruits.

Basically, vitamins are sold with instructions for use, which indicate how to take them correctly, how many times a day, after eating or before, but it is not always possible to drink them strictly on schedule, so it is best to take them for breakfast, at this time the body better assimilate all the useful substances.

Vitamins for a modern person are a very good help that allows the body to receive all the necessary substances for normal and healthy functioning. It is best to take vitamins in the morning, because it is in the morning that the activity of the intestines, and indeed of the whole organism, is the highest, which allows vitamins to be absorbed quickly and in a much larger volume.

Vitamins are the most commonly prescribed and taken drugs. If a person takes them for preventive purposes or to strengthen the body, then complexes are usually prescribed. If for the treatment of a certain disease, when certain substances are needed, then doctors prescribe vitamins separately.

It is recommended to take vitamins during the period of the greatest activity of the small intestine - due to its increased absorption, a large dose of useful substance enters the body. This is the ideal time to take vitamin A and E (either separately or in combination, such as Aevit).

For B vitamins, it is best to avoid contact with hydrochloric acid. Therefore, the optimal time for taking them is 7-12 hours. Vitamin C, on the contrary, is better absorbed after lunch, when the activity of the stomach and pancreas decreases.

Iodine taken after 11 p.m. is practically not absorbed by the body, so if you need its maximum benefit, try to meet the intake before this hour.

The human body functions around the clock, however, it is known that the biorhythms of diurnal animals, which include humans, are tuned so that during the day all organs work normally, and at night cell activity slows down. Therefore, all vitamins and minerals must be taken in the morning and at lunch, so that most of them are absorbed by the body and used for its benefit. The above has already written what I intended to write in my answer. However, I will say a few more words. Vitamins and minerals are absorbed differently in the body, and their combined intake (that is, simultaneous) leads to difficulty in their absorption from the digestive tract, in other words, they interfere with each other's absorption and are excreted almost unchanged, without bringing any benefit to the body. Therefore, those vitamin complexes are considered the best, in which the intake of minerals and vitamins is separated and they are taken at different times from each other.

In addition, it would be useful to refer to the instructions for use of the drug, where, as a rule, it is written that vitamins should be taken after meals, or during meals.

There can be several reasons for this, and one of them is in the diet.

The best way to control your appetite and stay active throughout the day is to eat 4-5 small meals a day.
At the same time, meals should be healthy, low-fat and healthy so that you are full and do not feel the desire to “intercept” anything extra.

• Never go more than 4 to 5 hours without food. It may seem strange, but the main mistake that leads to excess weight is systematic malnutrition. It has been proven that with 1-3 meals a day, people consume significantly more calories than with 4-5 meals a day.
• However, it is important not only to choose foods for your diet meticulously, but also to know at what time you need to eat each of them so that they bring maximum benefit. The fact is that at different times of the day the body needs foods of a certain nutritional value.

So, what exactly should you eat at each meal in order to stay slim and fit?

Breakfast (6 - 9 hours)

Studies show that 35% of women neglect their morning meal. Someone "does not have enough time", and someone seeks in this way to reduce the total number of calories consumed during the day.

However, as practice shows, the effect is exactly the opposite. During the day, the body will strive to catch up, and as a result, you will quietly eat much more food than you could.

Breakfast also performs another important function - it "starts" the metabolic process. That is, the foods that you eat during the day will be absorbed by the body faster and to a much greater extent.

Digestive enzymes are at their most active between 6 and 9 am, according to nutritionists. At this time, it is recommended to eat protein foods. Proteins are digested slowly, which will allow you not to feel hungry until lunch. Carbohydrates are best avoided - insulin levels are still low, and carbohydrate foods cause a decrease in blood sugar. As a result, by 11 o'clock in the afternoon you will want to eat again.

The best choice

1. Fat-free cottage cheese / yogurt. Yogurt is the healthiest food. It is rich in protein, calcium, magnesium, as well as beneficial microorganisms that increase immunity and improve the functioning of the gastrointestinal tract. But this only applies to natural yogurt. When adding various fruit fillers, sugar automatically appears in the composition of yogurt. Therefore, even if the jar says "0% fat", but the yogurt is strawberry, cherry, peach, etc. - then with a minimum of calorie benefits, it has plenty.

2. Cheese Yes, most cheeses are high in fat and calories. But at the same time, they contain a lot of calcium, and cheese also contains linoleic acid. It reduces the risk of cancer, cardiovascular disease and diabetes, and also ... contributes to weight loss, as it does not allow fat to be deposited. So that the cheese does not harm the figure, watch the serving size (the daily norm of this product per day is 2-3 thin slices or 4 cubes the size of a dice), and remember the oriental wisdom: "In the morning, cheese is gold, in the afternoon - silver, and in the evening - lead".

3. Oatmeal Oatmeal is a storehouse of fiber, complex carbohydrates and trace elements, it contains a high percentage of vegetable protein. Oatmeal is useful for the functioning of the liver and pancreas, regulates blood sugar levels, its fibers have a beneficial effect on metabolic processes, remove excess glucose, cholesterol, toxins and heavy metal impurities.

4. Milk Milk can lower blood pressure, and the calcium it contains is not only good for teeth and bones, but also prevents the deposition of fat in the body. According to studies by Italian scientists, subjects who included low-fat dairy products in their diet, ceteris paribus, lost weight 35% faster than those who excluded them from their diet.

5. Eggs This product contains about 6g of protein. In addition, it is rich in vitamins A, B6, B12, E, and the yolk contains rare vitamin K, folate, iron, lutein, which is necessary for maintaining vision, and choline, which helps to remove fat from the liver.

As for the cholesterol contained in eggs, according to many nutritionists, it is absorbed only by 30%, and therefore does not pose a serious threat to the heart.

Lunch (12 - 13 hours)

Lunch should include:

1. Proteins (fish, seafood; meat, poultry - give preference to lean parts). Cooking method - any: stew, bake, boil, grill - just do not fry!

2. Starchy foods (brown rice, wholemeal pasta, potatoes, whole grain bread, legumes).

"Proper" starchy foods are categorized as complex carbohydrates. They are absorbed more slowly, allow you to maintain a feeling of satiety longer, do not increase either sugar levels or excess weight. Moreover, they are all rich in fiber, without which weight loss is impossible. Fiber-rich foods are low in calories and almost no fat. Fiber is like a sponge: absorbing moisture, it swells and thus perfectly satisfies hunger.

The best choice

1. Brown rice It has a beneficial effect on the condition of hair, skin, teeth, nails, and is indispensable for digestion. There is a lot of fiber in the shell of brown rice, and it is rich in vitamins A, PP and group B, essential trace elements and phytochemicals, while being devoid of fat, cholesterol and sodium.

2. Pasta (from wholemeal flour) Provide you with fiber and folic acid, which is necessary for reproductive function and iron absorption. A standard serving of pasta (and this is one glass, no more!) From durum wheat will not cause the slightest harm to your figure.

3. Buckwheat porridge It contains iron, pectin, which improves digestion, as well as lecithin, which is necessary for the liver and pancreas.

4. Potato Source of antioxidants, vitamin C, potassium. A standard serving is one fist-sized tuber - about 100 kcal. Harmful for the figure (and not only!) Only fried potatoes, and also seasoned with fatty high-calorie sauces - cheese, sour cream, butter. Such a "zest" can add up to 150 kcal to a dish, and a few centimeters to your waist.

5. Whole grain bread Rich in fiber, complex carbohydrates, vitamins & minerals. The main cereal - wheat - contains a record amount of antioxidant orthophenols, fighters against cancer cells. But in white bread they are not at all - they were discovered by scientists only in the shell of the grain, which gets into the bran and wholemeal flour, but is peeled off during the manufacture of top-grade baking flour.

6. Legumes They are a storehouse of vegetable proteins, fiber and complex carbohydrates, but they are completely devoid of harmful saturated fats.

5. Salad from fresh vegetables with olive or vegetable oil.

6. A few words need to be said about soups . Don't underestimate this dish. Soups are the best cure for hunger. They will "warm" your stomach, improve the nutrition system. An American study found that those who sometimes include soup in their lunch diet consume 100 kcal less than those who refuse it. Moreover, this deficit is not compensated during the day. Give preference to soups of a thick consistency - from mashed vegetables or mashed soups - they will be both the first and second course at the same time, because if you choose soup, it is better to refuse snacks and hot on this day. In winter, soup is food not only for the body, but also for the soul, striving for warmth and peace.

Afternoon snack (16 - 17 hours)

At 16 - 17 hours comes the time for carbohydrate food - the level of insulin is maximum.

Right now your best bet would be:
- fruit or fruit salad,
- dried fruits,
- some nuts
- 30 g of dark chocolate (cocoa content - at least 70%). Cocoa beans are a source of antioxidants and flavonoids that reduce the risk of cardiovascular disease.

Just for lunch (and not for breakfast) , as many girls who follow their figure do), 1-2 times a week you can afford to enjoy dessert. In no case do not deny yourself sweets in general - severe restrictions will only lead to breakdowns. The main thing is to observe the measure in everything. It is better to give up saturated fat snacks, cookies, pastries and biscuits, switch to light desserts. One serving of low-calorie dessert has about 120 kcal. Suitable, for example, coffee or berry mousse, yogurt cake, fruit in jelly.

Dinner (18 - 20 hours)

One of the most "contradictory" meals. Some are of the opinion: you should never eat after 18:00, their opponents argue that only the total number of calories consumed during the day, and not the time of the meal, matters ... And the truth, as often happens, is in the middle. The most healthy and "safe" dinner for the figure is light, but not "hungry". It should consist of fish or lean white meat and a vegetable side dish (stewed vegetables are ideal).

Eating red meat in the evening is highly undesirable- it is digested for a long time, and digestive enzymes after 19:00 are practically not produced.
The common belief that salads are the most suitable food for dinner, not quite right. The fact is that during their processing, the pancreas, which has tuned in to rest, is subjected to a heavy load.

High carbohydrate foods should also be avoided. They will raise your blood sugar levels, which will create the illusion of hunger, and as a result, you will overeat.

If you follow the right diet, unexpected bouts of hunger are not terrible for either you or your figure. If you still want to eat something at night, a cup of weak green tea with a spoonful of honey or a glass of warm milk will help you out. They reduce gastric secretion and have a general calming effect.

A group of scientists from the University of Pennsylvania explained, why various medicines best taken at certain times of the day.

They found that the body has hours of maximum activity to be taken into account when prescribing drugs. It is reported by the BBC with reference to the work published by the National Academy of Sciences.

The researchers monitored the work of the internal organs of animals throughout the day. Every two hours they analyzed the work of DNA and cells kidney, adrenal, lungs, aorta, trunk brain, cerebellum, hypothalamus, brown and white fat, heart and other organs. Observations have shown that the greatest changes in cell activity occur before dawn and dusk.

Yes, 43 percent genes, which are involved in the production of proteins, showed different activity at different times. Moreover, the pattern of gene activity in different organs is different, so the peaks of cell activity do not always coincide..

Scientists hope to use the knowledge gained in the development of treatment regimens for various diseases. For example, cardiovascular disease is often associated with cholesterol. Because the liver produces the maximum amount of cholesterol at night, it is better to take medicines for it in the evening. Scientists have long identified such a pattern, but only now it has become clear what this is connected with.

“I hope we can use this information to develop better treatments with existing drugs. And this is very good, because it does not require additional funds. I think this is a real opportunity to improve medicine, and it will have amazing consequences,” said one of the participants in the study, Dr. John Hogenech.
Source: Medportal.ru

biological clock and
health optimization

I have always been interested in the question, - says Ivan Egorov, - what is The biological clock where they are and how to customize them to your advantage. Previously, I noticed that if I go to bed at twelve - one in the morning, the next day is lost for me. I walk broken and depressed! This happened until I completely upset my biological clock with night vigils. Nowadays, if I go to bed at 10 pm, then at 1 am it seems to me that it is already 6 am! And then there's the leapfrog with the translation of arrows ...

How often do we compare our mode of life with biological rhythms? Unfortunately, often forgetting about the internal clock, we allow ourselves to go to bed too late or sleep too long in the morning, overload ourselves with work, knock down the meal schedule, etc. This always has a very negative effect on our health. The body already endures constant loads and stresses in modern life, and we still aggravate the situation with the constantly straying rhythm of life.

It has been established that from 3 am to 3 pm the internal environment of the body is slightly acidic and the cell protoplasm is as mobile as possible. Because of this, the processes of splitting complex substances into simpler ones intensively occur. This is facilitated by sunlight and heat, a balanced diet and moderate physical activity. In the daytime, proteins are more actively broken down. In the second half of the day, when the illumination and the temperature of the external environment decrease, the energy supply of the cells decreases.

From 3 pm to 3 am acid-base balance passes into the weakly alkaline side, which contributes to the synthesis of more complex compounds from simple substances. In the protoplasm of cells, the viscosity increases, and internal processes slow down somewhat. In an alkaline environment, mainly carbohydrates and carbohydrate foods are broken down. And proteins eaten at night, due to the lack of enzymes and hydrochloric acid, are practically not digested until morning. They decompose under the influence of microorganisms, which leads to the formation of toxic endotoxins. As a result - nightmares, heavy awakening, headache, bad breath, fatigue and weakness.

If a person got up earlier, his brain suffers - the main regulator of all our internal processes. At first, this leads to poor health and headaches, to anxiety, depression, internal tension, ailments, and later to neuroses and other diseases. I emphasize again: the fourth phase of sleep depends on solar time, and not on how many hours a person slept.

During the hours of darkness, between midnight and four in the morning, the pituitary synthesizes and throws out in blood hormone melatonin, which controls quality sleep and recovery exhausted during the day of the internal organs.

If a person forced to work at night and rest during the day then full recovery life-supporting bodies and systems do not occur , because in people who are awake at night, the synthesis of melatonin is sharply reduced. And every day chronic fatigue builds up , not up to restored organs age rapidly, start to hurt develop atherosclerosis, cancer, reduced life expectancy.

Forcibly waking up very early on a dark winter morning reduces melatonin production and will result in the same effects as staying up all night no matter what the cause. This should know who follows the rules HLS.

One of the synchronizers intracellular biorhythm in is the change of day and night, and the deviation of the rhythms of work and rest, sleep and wakefulness from solar zone time (solar noon) leads to stress and desynchronosis, that is, a mismatch of the internal rhythms of the body with daily rhythms. Violation of these physiological rhythms leads to many diseases and to the rapid "burning" of the body.

Therefore, it is imperative that we take care of our health and learn to keep pace with the natural rhythms of our body, laid down by nature itself.

I decided to figure out what was the matter, and what time to “bind” my biological biorhythms in order to live fully and efficiently. An appeal to numerous publications on this matter did little, but I wanted to figure it out.

But let's start in order.

From numerous publications it is known that the work of our organs is subject to the daily biological, circadian rhythm.

Periods of daily activity of the main organs and systems:

23:00 - 01:00 - Gallbladder;
01:00 - 03:00 - Liver;
01:00 - 02:00 - Maximum activity of skin cell division,
therefore, before going to bed, it is advisable to apply a nourishing night cream to the skin;
03:00 - 05:00 - Light;
04:00 - 11:00 - Adrenals4
05:00 - 07:00 - Large intestine;
06:00 - 08:00 - Increase in blood pressure (by 20-30 points), the risk of hypertensive crises, strokes, heart attacks;
07:00 - 12:00 - Thyroid gland;
07:00 - 09:00 - Stomach;
07:00 - The body's susceptibility to aspirin and antihistamines increases: taken at this time, they remain in the blood longer and act more efficiently;
09:00 - 12:00 / 15:00 - 18:00 - Brain;
09:00 - 11:00 - Spleen and pancreas;
08:00 - 12:00 - Hypersensitivity to allergens, exacerbation of bronchial asthma.
11:00 - 13:00 - Heart;
13:00 - 15:00 - Small intestine;
15:00 - 17:00 - Bladder;
15:00 - Minimal sensitivity to allergens, but maximum - to anesthetics: favorable time for surgical interventions and dental treatment;
17:00 - 19:00 - Kidneys;
17:00 - Maximum muscle activity, aggravation of smell, hearing, taste sensations.
19:00 - 21:00 - Pericardium (shell of the heart);
19:00 - 21:00 - Reproductive and vascular system;
19:00 - It is at this time that in response to allergens, the release of histamine increases, an exacerbation of skin reactions occurs;
20:00 - Inflammatory processes worsen (time to take antibiotics);
21:00 - 23:00 - Triple Warmer, immune system.

Each person must know these laws of nature by heart and must strictly observe them in his daily life.

Simply put, biorhythms are subject to the vital activity of all living organisms at all levels of their existence. In accordance with them, cells divide, flowers bloom, animals hibernate, birds migrate ...

Biosphere land , man and all living beings live in a complex system of biorhythms. From short, with a period of a fraction of a second, at the molecular level. To more complex, diurnal, diurnal-annual, associated with annual changes solar activity .

Daily (circadian) rhythm The biological clock of a person can be represented as a clock face, indicating time intervals of approximately 2 hours and the activity of the main vital organs of the human body.

In the daytime, our body is dominated by metabolic processes aimed at extracting energy from the accumulated nutrients. At night, the energy reserve spent during the day is replenished, regeneration processes are activated, tissues are restored and internal organs are “repaired”.

What if the reference point (noon, solstice time), for example, in Moscow is one and a half hours behind the astronomical one? That is, in place of the heart, we should turn to the small intestine?

And what about the regions that are guided by Moscow time! There, the discrepancy between solar and direct time will be even greater. But the biological clock of a person needs to be wound up, tuned to natural internal rhythms and the clock of the external environment. The mode of nutrition, sleep, rest and physical activity allows you to maintain internal processes in the proper order.

But back to history.

Our distant ancestors, at the dawn of human history, intuitively recognized their inextricable connection with day and night luminaries. They endowed them with the features of mighty gods. The sun, many peoples revered him as the main deity. In ancient Egypt, grandiose temples were erected to the sun god Aton-Ra, and poetic hymns were composed in his honor.

And at the end of the 19th century, when the standard time system was introduced, most of the population - even in the most developed countries - was rural. And life in the countryside was largely regulated by the solar cycle. Then solar noon was also the middle of the daily activity of people.

The peasant himself regulated the rhythm of his life: in summer, when there was a lot of work, he got up at dawn, at 3-4 in the morning, in winter, when there was no field work, he could lie on the stove until nine (he did not know this: the peasants did not have hours, they lived and ate in the full sense of the Sun).

But now, most of the population lives in cities. Approaching the urban rhythm of life in the countryside. In the morning, at a certain hour that does not depend on the season - to work or study, in the evening - back, and there is still time for leisure before bedtime.

It is due to this leisure, an integral part of our life, that the daily activity of people has shifted relative to the solar noon to the evening side. We will live according to solar (standard) time - we will spend this leisure time in the dark all year round.

What solar standard time

Solar standard time is the most correct not only from an astronomical, but also from a physiological point of view. The natural daily rhythm of human life has evolved over thousands of years, but there is still an opinion that it can be arbitrarily changed. This opinion is supported by the widespread but unfounded belief that man is the king of nature and can arbitrarily dispose of it and himself as part of nature.

For example, it is easy and quick to adapt to an arbitrarily chosen time regime without taking into account the natural rhythm of the Earth's rotation. And during the life of one person, only temporary adaptation is possible, which occurs due to a more intensive expenditure of the body's reserves.

The inevitable depletion of reserves, functional disorders of the body, premature aging and reduced life expectancy become the price of adaptation. Go to any clinic. How many people are there?

Time Zones, GMT

Standard time is a system of counting hourly time, based on the division of the Earth's surface into 24 time zones, every 15 ° in longitude. Time within the same time zone is considered the same.

In 1884, at the International Conference, it was decided to apply this system. In accordance with the international agreement of 1883, the initial ("zero" meridian is the one that passes through the Greenwich Observatory in the suburbs of London. Local Greenwich time (GMT), agreed to be called universal or "World time" (Greenwich Mean Time). technologically named Universal Time Coordinated (UTC).

The agreed time in all other zones is calculated taking into account their serial number. So the standard time of Moscow and St. Petersburg, which are in the third time zone, differs from the world (Greenwich) time by three hours: when it is 12 o'clock in London, we already have 15 o'clock. Moscow Standard Time is MSK = UTC/GMT + 3 hours.

Physiological time, like local time on a rotating planet, has a cyclic character. For any clock, external or internal, adjusting (shifting) one or more full cycles has no noticeable effect. However, the shift of the biological clock by part of the cycle leads to tangible physiological consequences, as shown by the phenomenon of time difference during transmeridian flights.

This shift inside the cycle is called phase shift, that is, the positions of a repeating process in its own cycle (for example, the phases of the moon).

An hour compared to a day seems insignificant, but the effect of the period difference quickly accumulates. But synchronicity is important for living organisms, and in order to maintain it, you need to constantly make adjustments.

In the daily cycle, living organisms are guided by sunrise and sunset, as well as at the moment of maximum elevation of the Sun above the horizon, that is, true (astronomical) noon. These events served as reference points for calculating the time scale. The rotation of the planet by 15 degrees corresponds to a time period of one hour.

The earth is "sliced" into 24 slices of 15 degrees, each of which makes up one time zone. Noon on the clocks in each zone must coincide with the moment of true (astronomical) noon. The starting point for the zone division, the Greenwich meridian, is arbitrary. It's just that the British, using their influence, announced to the whole world in such a manner that they are the navel of the Earth.

Probably, there is no such person in the world who would not take medicine at least once in his life.
We know that not all medicines and vitamins are correctly combined with each other, while we do not take into account the fact that our body lives according to special energy clocks (biorhythms), which play an important role in our life. For example, they can enhance the effects of drugs or reduce their effectiveness.

During the day, there is a different sensitivity of the body to drugs and doses, as well as significant fluctuations in the intensity of absorption, distribution and withdrawal of drugs from the body.

If a take medicine in the phase of the greatest activity of a particular organ or system of the body and take into account the time of increased sensitivity of tissues to the substances taken, then you can:

Strengthen the therapeutic effect of the drug;
reduce the therapeutic dose of the drug;
reduce the frequency and severity of side effects.

So when is the best time to take your medication?

Since the biorhythms of a healthy and sick person are noticeably different, there are unified rules when is the best time to take medication does not exist. The schedule for taking the drugs is determined by the attending physician in accordance with your individual biorhythms!

However, it is worth noting the general principles that determine the prescription of drugs at certain times of the day.

1. Compliance of the action of drugs with the natural rhythms of the production of similar substances in the body.
2. Taking the medicine for a certain time before the expected deterioration in well-being.

Sometimes 1 tablet taken “at the right time” can replace a three-time intake, according to the instructions. This does not apply to all funds.

Consider the main groups of drugs, the intake of which definitely depends on the biorhythms of the body.

1. Heart remedies.
   As you know, the most dangerous time for the cores is morning. It is during the morning hours that the greatest number of heart attacks and strokes occur (6 o'clock in the morning is the most critical time). Often this is associated with a sharp rise in blood pressure after waking up. Therefore, in recent years, drugs with prolonged action have been increasingly used, taken in the evening(then in the morning the heart and blood vessels are protected).
   It is important to remember that in patients with cardiovascular diseases, biological rhythms are very individual, and the establishment of a daily medication intake should be strictly agreed with the attending physician.
   The general principles are:
   ♦ Antiarrhythmic drugs (anaprilin, obzidan) and potassium preparations (panangin, asparkam, potassium orotate) - best taken in the evening and midnight hours.
   ♦ Nitropreparations (nitrong, sustak, etc.) - take during the day.
   ♦ Antihypertensives - most of them are better to use rationally at 15-17 pm to prevent an increase in pressure in the evening hours (the maximum pressure is usually at 18-20 hours, but this is very individual), once daily dose.
   ♦ Lipid-lowering drugs (statins)- accept in the evening after dinner.
2. Preparations for the nervous system.
   ♦ Sedatives and tranquilizers - Take in the evening or before bed.
   ♦ Tonic and stimulant - taken in the morning.
3. Diuretics.
   ♦ Furosemide in chronic circulatory failure - it is better to take in 6-7 am on an empty stomach(at a dose of 20 mg). The maximum diuretic effect is observed at 10 am.
   ♦ Potassium-sparing diuretics(veroshpiron, etc.)- accept only in the evening (at 18 - 24 hours).
4. Analgesics.
   Analgesics are most effective after noon. At 2 p.m., the body is least sensitive to pain, so this time is ideal for painful procedures and the use of various analgesics.
   ♦ Acetylsalicylic acid (Aspirin) - should be taken according to the scheme: 1 tablet in the morning and 2 tablets in the evening(after meal); and for blood thinning - in the morning (after meal).
   ♦ Indomethacin - should be taken 8 am once at a dose of 100 mg (after meals), because in the evening, its concentration in the blood after the administration of the same dose is minimal.
   For rheumatoid arthritis- taking non-steroidal anti-inflammatory drugs in the evening, because The peak of pain in this disease occurs in the morning.
   With osteoarthritis pain medications are taken afternoon(The doctor can tell you the exact time).
5. Gastric drugs.
   ♦ Antacids – accepted during the day me and definitely overnight.
   ♦ Antiulcer drugs – most of them are better to take in the evening at 19 - 20 hours(daily dose in one dose), excluding the morning and afternoon intake of the drug.
   ♦ Antispasmodics with biliary dyskinesia - it is better to use in the evening at 22-23 hours.
   ♦ Diagnosis of stomach ulcers better to spend at 7 - 9 am, diagnostics duodenum - after lunch at 13 - 15 hours. During these periods, these diseases are especially active in signaling themselves with severe pain.
6. Hormonal preparations.
   ♦ Glucocorticoids (prednisolone, polcortolone, etc.) are taken 1 time per day in the morning (8-11 hours).
7. Asthma drugs.
   Attacks of suffocation often occur at 4 o'clock in the morning. That's why:
   ♦ Bronchodilators - recommended to use in the evening at 20-22 hours(it is desirable to take long-acting drugs - teopec, etc.). Short-acting drugs are taken in the late evening or at night.
   ♦ Steroid hormones asthmatics should use in the morning at 8:00 at a dose of 2/3 of the daily.
   ♦ Some inhaled corticosteroids (berotek) most effective (by bronchodilator effect) in the morning hours.
8. Antiallergic agents.
   In allergy sufferers, an increase in histamine is observed in the second half of the day and reaches its maximum value in the evening and at night. To suppress the action of histamine, allergy medications should be prescribed predominantly in the evening. Or transfer a significant part of the daily dose to this time.
   ♦ Antihistamines appoint in the afternoon (15 - 16 hours) and in the evening (19 - 21 hours).
   ♦ Antihistamines reparations prolonged action (from 8 hours or more) - accept once before going to bed - preferably at 23:00.
   ♦ Ketotifen(zaditen) most effective when taken 19 hours.
   ♦ Intal and Thailed most active afternoon (after 4 pm).
9. Sudfanilamide and antibiotics
   ♦ Sulfanilamide preparations maximally absorbed in the morning.
   ♦ Antibiotics, prescribed for a single daily intake, taken in the evening at 20 - 21 hours.
10. Minerals and vitamins
    ♦ Iron maximally absorbed and assimilated into evening hours.
    ♦ Calcium - desirable to drink overnight.
    ♦ Magnesium - can be drunk morning hours.
    ♦ vitamins - usually taken in the morning (after breakfast).
11. Therapeutic and preventive procedures
    ♦ 9 am - the best time for injections(prevention of swelling and fever), x-ray, ultrasound, fluorography(the body is more resistant at this time to X-ray exposure).
    ♦ Baths : 16 hours - iodine-bromine baths; 13 - 17 hours - coniferous and sodium chloride.
    ♦ Massage - the most efficient in the afternoon (17-18 hours).These tips are only advisory in nature and do not take into account the characteristics of different people. There is a special discipline that studies the relationship between human biorhythms and the time of taking medications - this is chronopharmacology. The topic covered is very complex, so it is always best to rely on the competence of your doctor and leave him the right to determine when it is best to take medication for a particular person.
    Be healthy!