Augmentin suspension for children dosage. Special antibiotic for children - Augmentin suspension

It is perhaps difficult to find a doctor who would never prescribe Augmentin. Therapists, pediatricians, urologists, gynecologists, ENT doctors - doctors of all specializations cannot imagine their practice without this antibiotic. At the same time, Augmentin is included in many protocols for the treatment of various diseases as the drug of choice, that is, recommended by the Ministry of Health.

Both patients and doctors perceive Augmentin as a modern antibacterial agent. Meanwhile, the drug has been on the market for more than a decade.

The combination of amoxicillin and clavulanic acid, which became the basis of Augmentin, was developed in 1977-1978 by scientists from the British company Beecham. A little later, in 1984, the pharmaceutical giant received a patent for the original Augmentin. Today, the drug continues to be manufactured by GlaxoSmithKline, Beecham's successor. WHO - World Health Organization - included Augmentin in the list of essential drugs.

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The popularity of the drug around the world is so high that it is among the ten best-selling antibiotics. Reviews of both patients and doctors about Augmentin are almost unanimous and only confirm the universal love for the drug.

Let's get to know each other better: the composition and form of release of Augmentin

Augmentin contains two substances:

• amoxicillin;
• clavulanic acid.

Amoxicillin is a semi-synthetic broad-spectrum penicillin antibiotic. It is practically an analogue of Ampicillin and differs only in small structural changes in the chemical formula. Augmentin contains amoxicillin in the form of trihydrate.

Clavulanic acid is a fermentation product of the gram-positive bacteria Streptomyces clavuligerus. This substance is part of Augmentin in the form of a potassium salt.

Augmentin is distinguished by the richness of its release forms. GlaxoSmithKline manufactures many different strengths of the drug. When specifying the dosage, the manufacturer indicates separately the dose of the antibiotic (first digit) and clavulanate (second digit). So, we list the forms of release of the drug, registered in Russia:

• Augmentin in the form of a dry powder for oral suspension, which contains 200 mg + 28.5 mg in 5 ml of the finished drug;
• Augmentin powder containing 400 mg + 57 mg in 5 ml of the finished suspension;
• Dry powder variant for oral suspension containing 125mg + 31.25mg per 5 ml of the finished drug;
• Augmentin ES powder for the preparation of a children's suspension, which contains 600 mg + 42.9 mg in 5 ml;
• Augmentin powder intended for the preparation of a solution for intravenous administration;
• Tablets 500mg + 125mg;
• Tablets 875 mg + 125 mg;
• Augmentin tablets 250mg + 125mg.

Each tablet of the drug is film-coated, which protects the active substances from the action of the aggressive hydrochloric acid environment of the stomach.

Sometimes doctors, prescribing Augmentin, indicate the total dosage of the antibiotic and clavulanic acid. For example, you can often find a recipe with similar content: Tab.Augmentini 1000mg. Obviously, the doctor is referring to the formulation of the antibiotic containing 875 mg of amoxicillin and 125 mg of clavulanic acid. Both the first and the second method of indicating the dosage are equally correct.

The richness of release forms is another advantage

GlaxoSmithKline has mastered the production of such a large number of different forms of Augmentin that the antibiotic can be easily selected for a patient of any age and weight. The search for new convenient doses continues to this day. So, relatively recently, a children's suspension of Augmentin ES was registered, designed for the treatment of severe infections, as well as for older children. The drug has an almost adult dosage of active ingredients - 600 mg of Amoxicillin and 42.9 mg of clavulanic acid.

I would like to note that the package of Augmentin contains exactly the number of tablets calculated for a full course of treatment. Thus, the minimum package of the drug contains 14 tablets and is designed for a treatment regimen for uncomplicated infections. For long-term treatment, a release form of 20 tablets of Augmentin with a dose of 625 mg and 400 mg is intended.

When buying a suspension of Augmentin, the dosage of which is correctly calculated based on the weight of the child, there is no doubt that the volume of the drug will be more than enough for the course of treatment. Sometimes parents are surprised to notice that on the third day of antibiotic therapy, only a small fraction of the medicine remains in the vial. In such cases, most likely, the release form was chosen incorrectly, and it was necessary to buy a large dosage of the drug.

We save wisely, or is it possible to divide the Augmentin pill?

On some tablets of Augmentin, in particular, a dosage of 500 mg (675 mg including clavulanate), a transverse risk is applied. Many patients feel that risk is needed to split the pills in order to reduce the dosage.

Of course, from the point of view of savings, this is really beneficial. After all, the cost of, for example, Augmentin 250 mg tablets is much higher than half a 500 mg tablet. However, in fact, the manufacturer warns: the transverse risk is applied not at all to select a lower dosage. The risk in Augmentin tablets performs rather an aesthetic function. Separation of the tablet is categorically not recommended: after all, then the film shell is destroyed, and the contents of the tablet can react with the hydrochloric acid of the stomach.

In addition, pharmacists pay attention to the fact that when a tablet is broken at risk into two parts, it is almost impossible to predict the content of active ingredients in the resulting halves. And the likelihood that both parts of the pill will be equal in dosage is very illusory.

Therefore, do not be wise. Fortunately, Augmentin favorably distinguishes the richness of the release forms, and each patient, regardless of age and weight, can choose the right dosage.

Protection of Amoxicillin, or Why are clavulanates needed?

Indeed, many patients wonder what is the function of clavulanic acid? Why does the drug include another substance?

The fact is that during the use of antibacterial drugs, many microorganisms have learned to resist the action of drugs. Cunning bacteria in an effort to continue their vital activity began to produce a special enzyme that destroys the antibiotic. Thus, drugs of the penicillin and cephalosporin series, containing a beta-lactam ring, are inactivated by the action of penicillinase, which is produced by some microorganisms.

Scientists discovered this ability of bacteria immediately after the creation of Amoxicillin. Soon, an "antidote" was found, which turned out to be clavulanic acid. It is structurally similar to beta-lactam penicillins.

Clavulanic acid inactivates beta-lactamases (a group of enzymes, which includes penicillinase), blocking the active sites of these enzymes.

So, clavulanic acid in the composition of antibacterial drugs acts as a protector. It does not allow bacteria to destroy the antibiotic and thus preserves its physico-chemical structure, and, consequently, the pharmacological action.

I would like to note that not all microorganisms produce penicillinase. Therefore, pure, unprotected Amoxicillin is still successfully used to treat diseases caused by susceptible bacteria.

Augmentin: spectrum of activity and pharmacological action

Many gram-positive and gram-negative bacteria are sensitive to the action of Augmentin, including:

• Staphylococcus aureus, including beta-lactamase producing strains;
• streptococcus;
• neisseria, the causative agent of gonorrhea;
• Escherichia coli, including those producing beta-lactamase;
• enterobacteria;
• klebsiella;
• moraxella;
• Proteus.

Separately, we note that methicillin-resistant strains of Staphylococcus aureus, which cause dangerous nosocomial infections, are insensitive to Augmentin.

The mechanism of action of Amoxicillin is extremely simple. The antibiotic blocks the synthesis of the cell wall of sensitive microorganism and thus has a bactericidal effect.

Pharmacological effect in Augmentin has only one active ingredient of the drug - amoxicillin. Clavulanic acid has no antibacterial effect.

Bioavailability of Augmentin before and after meals: when is the best time to take an antibiotic?

The complex of Amoxicillin and potassium clavulanate is well absorbed. Within an hour after oral administration, the blood contains the maximum concentration of the antibiotic.

The rate of absorption and distribution of the main active ingredient - Amoxicillin - is the same regardless of food intake. However, for potassium clavulanate, the dosing regimen still matters. In clinical trials, the absorption of clavulanic acid has been found to be much higher when taken with food than on an empty stomach.

GlaxoSmithKline scientists have conducted studies to study the pharmacokinetics of the drug. It was found that the relative bioavailability of Augmentin was significantly reduced when taken orally 30 and 150 minutes after a high-fat breakfast.

Based on the study of pharmacodynamics, uniform recommendations were developed for taking Augmentin tablets and suspensions for children. So, in order for the maximum doses of the drug to reach the destination, the medicine must be taken at the beginning of the meal.

Indications for use: when will Augmentin help?

Indications for taking Augmentin are inflammatory diseases that are caused by pathogens that are sensitive to Amoxicillin. We have already mentioned that Augmentin is one of the drugs of choice in the treatment of many infectious pathologies. Let's try to list the main indications for the use of this really powerful antibiotic:

• infections of the upper respiratory tract, in particular, bronchitis (inflammation of the bronchi), bronchopneumonia (simultaneous inflammation of the bronchi and lungs), pneumonia (pneumonia), lung abscesses (abscesses);
• infections of the oropharynx: bacterial tonsillitis (tonsillitis), pharyngitis, stomatitis;
• ENT infections: otitis media, sinusitis (article "Antibiotics for sinusitis");
• skin infections: bacterial furunculosis and other pathologies caused by beta-lactamase-producing strains of Staphylococcus aureus, Klebsiella and Escherichia coli;
• infections of the genitourinary system: cystitis (inflammation of the bladder), pyelonephritis (inflammation of the kidneys), urethritis (inflammation of the urethra - urethra);
• infections of the pelvic organs, including after childbirth, abortion and other interventions;
• sexually transmitted diseases: gonorrhea, syphilis;
• postoperative infections;
• osteomyelitis - inflammation of bone tissue.

Application of Augmentin: special instructions

First of all, I would like to emphasize that Augmentin is the gold standard in the treatment of diseases of the oropharynx, upper and lower respiratory tract, caused mainly by gram-positive microorganisms. At the same time, the spectrum of the drug is so wide that it is able to cover almost all pathogenic microorganisms.

Unfortunately, many therapists like to hide behind two or even three antibiotics. Often vigilant doctors reinsure themselves in this way during outpatient and even inpatient treatment of pneumonia. As a result, the treatment regimen for uncomplicated pneumonia takes on a “multi-story look” and contains several antibiotics, including Augmentin. At the same time, combinations of injectable and tablet forms of various antibacterial drugs look especially impressive.

Patients are not even aware that a properly selected Augmentin does not require the addition of another antibiotic. The activity of Amoxicillin against Streptococcus pneumoniae (the main causative agent of pneumonia) is significantly higher than that of Ampicillin and Benzylpenicillin. Therefore, in the vast majority of cases of pneumonia caused by strains with intermediate sensitivity to Ampicillin and Benzylpenicillin, amenable to monotherapy with Augmentin.

In the treatment of infections of the urogenital tract (inflammation of the kidneys, bladder, pelvic organs), antibiotics of the fluoroquinolone series are still considered the drugs of choice. However, drugs in this group are contraindicated for use in children. Therefore, in pediatric practice, Augmentin can be used for such infections.

Suspension or syringe: why do we torture children

Many patients believe that the effectiveness of an antibiotic that is injected is higher than oral forms - tablets or suspensions. Apparently, this opinion has taken root in the minds of mainly our compatriots since the days of Soviet medicine. Then, indeed, doctors preferred parenteral antibiotics, and there was some common sense in this. Oral forms of those years were distinguished by low bioavailability. A striking example is Ampicillin, which is only 40% absorbed. And it is excreted very quickly, which is why the tablets have to be taken four times a day.

Since then, the pharmaceutical industry has come a long way. So far that there are oral antibiotics with bioavailability approaching that of injectable forms. Simply put, modern antibiotics in tablets or suspensions are no “weaker” than injections. And sometimes even vice versa.

The problem is that the vast majority of patients and even a certain number of physicians bogged down in the past do not know about it. Or they don't want to know. And in such situations, a modern drama is played out with the participation of parents, a doctor and, of course, the victim - a child.

Parents beg the district pediatrician to prescribe “shots” in order to cure the child quickly and for sure. Doctors, for the sake of worried mothers, paint terrible schemes for diluting adult doses of injectable antibiotics. Mom, armed with a syringe and a can of alcohol, examines the fifth point of the child and looks for the treasured upper left quadrant. And the child at this time calls for help from all relatives and receives unchildish stress. In general, the picture is impressive.

Meanwhile, in the vast majority of infectious diseases, the action of modern tableted antibiotics is sufficient to achieve the maximum possible effect. Injections, including Augmentin, are used only for very serious diseases: post-surgical inflammatory processes, nosocomial infections, as well as for pathologies against the background of immunosuppression.

Children's suspension of Augmentin has not only high bioavailability, but also another important quality for a child - a pleasant taste. Therefore, let's start breaking stereotypes and treat our children effectively, safely and even pleasantly. And with the help of Augmentin suspension as well.

The correct dosage for children is the basis for successful treatment with Augmentin

According to the instructions for the use of Augmentin in children, the dosage of the drug depends on the age of the child.

- Babies up to three months

In children of this age, the urinary system is not yet fully functional, as a result of which the elimination (removal) of standard doses of Augmentin may be difficult. Therefore, the recommended dosage of the drug is 30 milligrams per kilogram of body weight per day. The multiplicity of reception - twice a day, that is, every 12 hours.

It is most convenient to buy a children's suspension of Augmentin containing 125 mg of Amoxicillin.

- Children older than three months

Starting from this age, the doctor may prescribe two options for the children's suspension:

1. Augmentin 200 mg in 5 ml and Augmentin 400 mg in 5 ml are applied twice a day, every 12 hours.

2. Augmentin 125 mg in 5 ml and Augmentin 250 mg in 5 ml are used three times a day - every 8 hours.

Most experts prefer to use suspensions with a 12-hour action. It is assumed that these dosage forms are much less likely to cause diarrhea than the 8-hour suspension of Augmentin.

However, it should be borne in mind that Augmentin 200 mg and 400 mg suspensions contain aspartame, so they are prohibited for use in patients suffering from phenylketonuria.

Let's try to figure out how to calculate the dose of children's Augmentin.

The instructions for use state that:

• Augmentin 12-hour children's suspensions are dosed based on the calculation of 45 mg / kg of weight for severe infections and 25 mg / kg for less severe ones;
• Augmentin 8-hour suspensions are designed for 40 mg / kg in severe cases and 20 mg / kg in mild cases.

Under the concept of "severe infections" specialists mean otitis media, infections of the lower respiratory tract (pneumonia), sinusitis and diseases with severe intoxication and vivid symptoms.

Let's take an example. If the weight of the child is 8 kg, then with moderate bronchitis, he will need 200 mg of Augmentin per day, divided into two doses. Based on the fact that 5 ml of the finished suspension contains 200 mg of the antibiotic, the child should receive 2.5 ml of the drug every 12 hours.

- Children weighing 40 kg and above

For children of the older age category, Augmentin is dosed in accordance with adult recommendations.

In conclusion, the description of the standard dosages of Augmentin would like to note the importance of a competent doctor's consultation. Despite the sometimes detailed description of the calculation of the child's dose in the instructions or articles about Augmentin, it is best not to engage in amateur activities with the selection of dosages, but to give the reins to a specialist. Only a doctor can adequately assess the severity of your child's disease and choose the right dose of antibiotic. Remember this and do not overestimate your capabilities. Also, always check the instructions that are offered directly to the medicine.

Augmentin: adult dosages

With dosages for adults, the situation is much simpler. However, here it is necessary to take into account the severity of the disease.

The instructions for use of Augmentin tablets describe that the standard adult dose includes 500 mg of the drug every 12 hours or 250 mg every 8 hours.

For the treatment of more severe diseases and infections of the lower respiratory tract, the dose of Augmentin is increased to 875 mg every 12 hours or 500 mg every 8 hours.

Adults who have difficulty swallowing a whole tablet may take the 125 mg or 250 mg suspension instead of Augmentin 500 mg. Tablets at a dose of 875 mg are replaced in such cases with a suspension of Augmentin containing 200 or 400 mg of the antibiotic.

Rules for the preparation of Augmentin suspension: we translate the instructions from medical into Russian

Children's suspension of Augmentin is sold as a dry powder, from which parents must prepare the final product with their own hands. Many mothers and fathers who are unfamiliar with pharmaceutical activities, even after carefully studying the instructions for Augmentin, are afraid to make a mistake in this delicate matter - the manufacture of a medicine.

Let's try to figure out how to prepare a suspension. But first, let's remember that Augmentin is a very high-quality original drug. And this quality is manifested literally in everything, from packaging to efficiency. That is why preparing medicine is a pleasure.

To obtain a suspension, we need cool boiled or highly purified water. So let's start with the bottle itself. There is a cross mark on its label. It shows the level to which the finished suspension of Augmentin should reach.

The preparation of any suspension is carried out in two stages:

• dilution in half the volume of the solvent. To do this, pour approximately 1/2 of water (relative to the mark) and try to distribute the powder as much as possible by shaking the bottle vigorously;
• final breeding. At this stage, it is necessary to add water already to the mark, shake well and the cooking process can be considered complete.

As you can see, it's actually very simple. The only subtlety of preparation is the exact measurement of the required volume of water. The final dosage of the drug depends on this. If the solvent does not reach the mark, the concentration of the antibiotic in the suspension will exceed the norm. If we do not spare water and in a fit of generosity pour it above the mark, we will get a “diluted” suspension of Augmentin, the dose of which is lower than necessary.

Both the first and the second mistake affect the effectiveness and outcome of treatment.

Augmentin suspension - where to store and how to take?

Suspensions and emulsions are two-phase systems. Take a closer look at the finished suspension of Augmentin: the powder does not dissolve, but is simply distributed in water. You can not worry - it's not your inability to prepare medicines. It's just that Amoxicillin, like most other antibiotics, is completely insoluble in water.

Therefore, one of the main tasks of a parent who treats a child with an antibiotic suspension is to follow the rule of taking a two-phase medication. The amount of active substance that will enter the body ultimately depends on the relative homogeneity of the suspension.

So, how to take Augmentin suspension correctly? There is nothing simpler: just before use, the medicine bottle must be shaken vigorously.

Store the finished suspension of Agumentin in the refrigerator. Emphasize the word "ready". If you bought the drug in advance, then an ordinary shelf in a closed cabinet is enough for Augmentin powder to retain its properties.

If at the end of treatment a certain amount of medicine remains unused, do not leave it "just in case". Augmentin suspension can be stored for about three weeks, after which the antibiotic is destroyed.

Penicillin Allergy: Don't Miss It!

The main contraindication to taking Augmentin is an allergic reaction to penicillin antibiotics.

During the post-marketing studies of Augmentin, which have been going on for about 30 years, a number of rather severe cases of individual hypersensitivity to the drug have been registered. They were manifested by an anaphylactic reaction to the penicillin antibiotic Amoxicillin.

I would like to reassure patients who still did not know anything about allergies. All cases of individual reactions to Augmentin occurred in patients allergic to penicillin drugs or other allergens in an amount of more than two.

In addition, cross-sensitivity between penicillin and cephalosporin antibiotics should be taken into account. If the patient had a history of allergy to, say, ceftriaxone, then the likelihood of a reaction to Augmentin is very high. In such situations, it’s definitely not worth the risk - it’s much easier and safer to choose an antibiotic from another group.

Contraindications to treatment with Augmentin

Let's try to list the main contraindications for taking Augmentin:

• allergic reaction to penicillin or cephalosporin antibiotics;
• abnormal liver function during treatment with Augmentin in history (that is, with a previous dose of the drug);
• individual intolerance to the components of Augmentin;
• Infectious mononucleosis. The erroneous appointment of penicillins in this disease (we note, a viral disease) leads to the appearance of a characteristic rash.

During pregnancy and lactation, Augmentin is allowed conditionally. This very vague phrase only means that a sufficient number of clinical studies studying the effect of the drug on the course of pregnancy have not been conducted. The drug, no doubt, penetrates the placental barrier and into breast milk.

However, due to the extremely low toxicity and wide spectrum of action of Augmentin, this particular antibiotic is the drug of choice in the treatment of many infectious diseases in both pregnant and lactating women.

Side effects of Augmentin: what can you expect?

Let's try to list the main adverse events that may occur during or after a course of treatment with Augmentin:

- disruption of the intestines

The so-called "dysbiosis", which doctors and pharmacists scare us with, sometimes really develops after taking antibiotics. In medicine, this phenomenon is called pseudomembranous colitis. The reason for this complication is that antibiotic treatment can alter the normal intestinal flora. At the same time, conditionally pathogenic microorganisms can begin to multiply intensively and produce toxins.

Studies show that the main cause of antibiotic-associated colitis is a toxin produced by Clostridia. Diarrhea, which is most often the only symptom of a complication, can vary in severity from mild in most cases to severe. The latter is most often recorded in patients suffering from immunodeficiency.

On average, antibiotic-associated diarrhea occurs in 9% of patients taking Augmentin.

- impaired liver function

The negative effect of Augmentin on the functioning of the liver and biliary tract is recorded in less than 5% of cases. At the same time, in most patients, the function of the hepatobiliary system is restored independently after the antibiotic is discontinued.

Severe disorders, which are manifested by damage to the liver tissue, have been reported in isolated cases. For example, GlaxoSmithKline confirms information about one death as a result of the hepatotoxic effect of Augmentin. However, we hasten to reassure the patients who took up the heart. The probability of such a reaction approaches zero - it is possible only in one of 4,000,000 patients!

Nevertheless, in order to avoid complications, during long-term treatment with Augmentin, experts recommend periodically monitoring liver function.

- allergic dermatitis

The probability of occurrence of dermatological rashes during therapy with Augmentin is 3%. As a rule, these symptoms do not require discontinuation of the antibiotic and disappear at the end of treatment.

- nausea and vomiting

In some patients, dyspeptic phenomena associated with taking Augmentin are recorded: nausea (in 3% of patients) and vomiting (in 1%). To reduce the likelihood of these side effects, you need to follow the rules for taking Augmentin and take the medicine at the beginning of a meal.

Augmentin analogues: a choice that boggles the imagination

As we have already mentioned, Augmentin is the original drug. It was with him that the era of protected Amoxicillin began. Therefore, its quality and safety are beyond doubt.

However, this does not mean that generics, that is, analogues of Augmentin, work worse or cause more side effects. After all, each analogue is tested for bioequivalence. The ideal generic has the same resemblance to the original as two identical drugs from different series. And the price of an analogue is almost always lower than the drug-brand.

So, let's try to list the most common analogues of Augmentin. And let's start, of course, with the highest quality:

• Amoxiclav - the Slovak analogue of Augmentin;
• Flemoclav is an orodispersible form of protected amoxicillin that is highly bioavailable and easy to take. There is no doubt about the quality of the Dutch manufacturer of this drug Astellas;
• Medoklav, the manufacturer of which is the Cypriot company MEDOCHEMIE LTD;
• Panklav is a fairly economical and at the same time high-quality generic, which is produced by the European company Hemofarm.

Separately, I would like to list the Indian analogues of Augmentin. These drugs belong to the cheaper segment of the market. On the Russian market, more often than others you can find:

• ranclave;
• Rapiclav;
• Amoxicomb.

Russian generics meet quality standards and compare favorably with a democratic price. Among them, the most common are:

• Arlet (manufacturer - AKO Sintez);
• Ecoclave manufactured by JSC Avva Rus;
• Klamosar, which produces the Saransk JSC "Biochemist".

As you can see, the choice is really wide. Nevertheless, it is still better to leave the right to make a decision to a specialist: the attending physician or pharmacist.

Augmentin ® is a combined antimicrobial medication, which includes amoxicillin, which acts bactericidal, and clavulanic acid (clavulanate), which inhibits a group of bacterial enzymes - β-lactamase. The latter hydrolyze antibiotics of the penicillin and cephalosporin series, as a result of which the latter do not have time to show their antimicrobial effect. Augmentin ® is a drug with an extended spectrum of activity.

Aerobes and anaerobes are sensitive to Augmentin ®. The antibiotic has a bacteriolytic effect, i.e. destroys pathogenic microorganisms. By itself, amoxicillin degrades in the presence of β-lactamase, so it is ineffective in the eradication of microbial cultures that synthesize these enzymes. Clavulanic acid, which is part of the drug, gives stability to semi-synthetic penicillin, thereby expanding the spectrum of its activity.

Clavulanic acid is similar in structure to the antibiotics of the penicillin series. Susceptibility to clavulanate is possessed by plasmid - β-lactamases, which determine the resistance (resistance) of pathogens. However, the inhibitor has no effect on type 1 bacterial enzymes. The country of origin of Augmentin ® is England.

Instructions for use of tablets Augmentin ® 1000, 875 125, 500 and 125 mg

Tablets are not crushed and chewed, but swallowed whole, and washed down with clean non-carbonated water (100 milliliters is enough). As for the suspension, the required amount of the finished solution is measured using a measuring cap or a syringe, on which divisions are applied. Wash the syringe or measuring cup thoroughly after use.

Augmentin ® in liquid form (suspension) is preferably taken before meals, which significantly improves absorption. In addition, this will reduce the likelihood of unwanted reactions from the esophagus, stomach and intestines.

The suspension is used exclusively orally. Pour 0.06 liters of boiled water at room temperature into a container with powder. The vial is tightly closed with a lid and shaken thoroughly until a homogeneous mass is obtained.

The powder will completely dissolve if left for a few minutes. Then the procedure is repeated, adding water to the mark on the vial. The shelf life of the prepared solution is a week, it is stored in the common chamber of the refrigerator. The suspension preparation technology is described in detail in the insert enclosed in the package.

All dosage forms are taken at the same intervals. For example, if a doctor prescribed taking an antibiotic twice a day, then this means that Augmentin ® should be ingested every 12 hours.

The minimum course of treatment with Augmentin ® is five days. After diagnosis and in the absence of re-examination, therapy should not last more than 14 days. If, during the revision of the clinical situation, although a slow but positive dynamics of the recovery process was revealed, then the course of treatment is continued. The duration of the course should be agreed with the attending physician.

Specialists often resort to stepwise antibiotic therapy, which involves a 2-stage use of antibiotic drugs: for example, switching from parenteral to oral administration. In the case of Augmentin ®, the injection method is first practiced, and then tablets are used.

Pharmacological group

Augmentin ® also belongs to the group of inhibitor-protected penicillins.

Pharmacological parameters

Augmentin ® causes the death of facultative flora and blocks the biosynthesis of the cell membrane, which performs structural, protective and transport functions. Amoxicillin, together with clavulanic acid, enhance the bactericidal activity of segmented neutrophils, which play a very important role in protecting the body from infections of bacterial and fungal etiology. Clavulanic acid stimulates the adhesion and motor response of neutrophils (leukocytes) to a chemical stimulus.

Pharmacology of amoxicillin

Amoxicillin is destroyed by penicillinase. The antibiotic is acid resistant. Its target is the bacterial enzyme glycopeptide transpeptidase. The antimicrobial agent inhibits the synthesis of murein, which performs the antigenic and mechanical functions of the osmotic protection of the cell.

Pharmacology of clavulanic acid

Clavulanate has its own antimicrobial activity. Pseudomonas aeruginosa and Enterococcus are sensitive to the inhibitor (minimum activity); Haemophilus influenzae and Enterobacteriaceae (moderate activity); Bacteroides, Moraxella, Staphylococcus, Streptococcus, Neisseria gonorrhoeae, Chlamydia trachomatis and Legionella (high activity). Like other β-lactam antibiotics, clavulanic acid interacts with penicillin-binding proteins of gram+ and gram-causative agents and contributes to the dissolution of the cell membrane.

Pharmacokinetic parameters

Pharmacokinetic data obtained in experimental and laboratory studies in volunteers after administration on an empty stomach.

Rapid achievement of effective drug concentration in plasma

The drug is rapidly and completely absorbed from the gastrointestinal tract. The absorption of the active ingredients of Augmentin ® is optimal when taken before meals. The time to reach max concentration is 3/4 hours.

Distribution of drugs. agents in the body

Therapeutic concentrations of amoxicillin and clavulanate are formed in the organs of the chest and abdominal cavity, adipose tissue, bones, muscles, bile, serous-purulent discharge and fluids: pleural, produced by the pleura, synovial, filling the joints, peritoneal, responsible for moisturizing the abdominal wall, and tissue contained in the pericellular spaces. The degree of binding to plasma proteins is low (no more than thirty percent for both substances).

Metabolism and elimination

The antibiotic is eliminated by the kidneys (glomerular filtration and tubular secretion). After a 1-time oral intake, both substances are excreted from the body in six hours. The elimination half-life depends on the dose, the average is one hour.

Composition of Augmentin ®

The main components of the antibiotic are Amoxicillin (amoxicillin) and Clavulanic acid (clavulanic acid), with the physiological action of which the healing properties of Augmentin ® are associated. The composition includes xanthan gum (stabilizer, whitish powder, odorless and tasteless), L-Aspartyl-L-phenylalanine (sweetener), butanedioic acid (colorless crystals, soluble in water and ethanol) and food flavorings (aroma of berries and citrus fruits) .

Augmentin ® recipe in Latin

Rp: Augmentini 0.875.

D.t. d. No. 20 in tab.

S. 1 tablet 2 times a day

Release form Augmentin ®

The pharmaceutical industry produces Augmentin ® in the form of:

1. white powder having a specific smell. When water is added, a suspension of a similar shade is formed. After settling in the tank, a precipitate gradually forms.
2. tablet form containing 250 milligrams of Amoxycillinum and 125 milligrams of clavulanic acid. The tablets are film-coated, the name "Augmentin ®" is engraved on the surface in Latin.
3. tablet form containing 500 milligrams of Amoxycillinum and 125 milligrams of clavulanic acid. On one side of the table marked with the letters "AC".
4. tablet form containing 875 milligrams of Amoxycillinum and 125 milligrams of clavulanic acid. On the top and bottom side, the letters "A" and "C" are carved. Pharmaceutical corporation GlaxoSmithkline ® does not supply Augmentin ® syrup for children to the pharmaceutical market.

What helps Augmentin ®?

Augmentin ® is active against pathogens susceptible to it. The combined drug is prescribed for infections caused by microorganisms that are resistant to the antibiotic that is part of the antibiotic.

Taking Augmentin ® contributes to the eradication of the following microbial cultures:

• gram + aerobes that need free molecular oxygen for energy synthesis processes (including strains synthesizing β-lactamases): Staphylococcus aureus, St. epidermal, Streptococcus, Pneumococcus, Fecal Enterococcus, Corynebacterium, Listeria;
• gram aerobes: coli, proteus mirabilis;
• gram + anaerobes, receiving energy in the absence of oxygen access: Clostridium, Peptostreptococcus, Peptococcus, Proteus, Klebsiella, Salmonella, Shigella, Borde-Jangu bacterium, Yersinia enterocolitis, Campylobacter jejuni
• and etc. gram + pathogens: bacteroides, including bacteroides fragilis.

Indications for use Augmentin ®

The combination of amoxicillin with clavulanate is indicated in the treatment of diseases of bacterial origin in the following localizations:

• ENT organs: tonsillitis, sinusitis, otitis media (including relapses). The causative agents are pyogenic streptococcus, pneumococcus, influenza bacillus.
• lower parts of the respiratory system: exacerbation of chronic bronchitis, pyothorax, abscessing, bronchogenic and lobar pneumonia, developing with invasion of the body by pneumococci and influenza bacillus.
• urinary system and reproductive organs: cystitis, pelvioperitonitis, endometritis, urethritis, pyelonephritis and diseases of the female organs of the reproductive system: vaginitis, salpingo-oophoritis, inflammatory adnexumor (enterobacteria, Escherichia coli, saprophytic staphylococcus, enterococci, gonococcus that causes gonorrhea).
• dermis and soft tissues, which include muscles, tendons, synovial membranes, adipose tissue, fibrous connective tissue: inflammation of the subcutaneous tissue, purulent inflammation of tissues, furunculosis, panniculitis (staphylococcus aureus, st. pyogenic, bacteroids).
• bone: purulent-necrotic processes developing in the bone and bone marrow (staphylococcus aureus). Augmentin ® is prescribed if long-term treatment is necessary.
• oral cavity: periodontal inflammation,
  maxillary sinusitis, severe dentoalveolar abscesses.

Indications for use include septic abortion, obstetric and intra-abdominal sepsis, septicemia, peritonitis, cholecystitis.

Who is contraindicated for Augmentin ®

The antibiotic is not prescribed to patients with a history of hypersensitivity to amoxicillin, clavulanate, β-lactams, and other components. The grounds for refusing therapy with this drug are:

• phenylketonuria is a hereditary disease caused by a metabolic disorder of α-amino-β-phenylpropionic acid;
• kidney pathology and other severe dysfunctions, for example, low creatinine;
• infancy up to three months (for suspension);
• age up to twelve years and weight less than forty kilograms (for solid. lek. forms);
• lymphoblastosis is benign, since an antibiotic can provoke the appearance of rashes, which will make it difficult to make a diagnosis;
• prior episodes of Gospell's disease.

Dosage of Augmentin ® for adults

Establishing a dosing regimen is the responsibility of the attending physician. When choosing a dosage, the doctor takes into account age, weight, the presence of diseases of the urinary system, the clinical condition of the patient, and individual characteristics.

Adults and children at puberty (adolescents from twelve years of age or with a body weight exceeding forty kg) should be given eleven milliliters of suspension at a dosage of 400 mg plus 57 mg, which is equivalent to one tablet containing 875 mg of amoxicillin.

Low doses of the drug Augmentin ® are indicated for getting rid of skin infections and for recurrent inflammation of the tonsils. High doses are indispensable in the treatment of otitis media, sinusitis, infections of the bone and joint tissues.

For infants under three months, due to the incompletely formed excretory function of the kidneys, the recommended dose is thirty milligrams per kg of body weight. As for premature babies, there are no reliable data on the dosing regimen.

Patients over the age of sixty do not need to adjust the dosage. It is necessary to adhere to the recommendations that guide the treatment of young patients.

In persons with liver dysfunction, antibiotic therapy should be given with caution, with liver function screening performed on a regular basis.

For persons with renal insufficiency, the dosage regimen is adjusted based on the assessment of creatinine clearance, which is the main quantitative indicator of the secretory organ.

Dosage of Augmentin ® for children in suspension 200 and 400 ml

In pediatric practice, Augmentin ® is prescribed to children in the form of a suspension.

How to correctly calculate the dosage of Augmentin ® suspension for children (200 mg, 400 mg)

Parents can not always correctly determine the dosing regimen. For clarity, we give an example of calculating the dosage for a girl in whom the therapist diagnosed inflammation of the bronchial mucosa. The age of the child is one and a half years, and the weight is ten kg.

Bronchitis leads to disruption of the normal functioning of a vital organ, if the disease occurs without respiratory failure, then the patient's condition is classified as moderate.

For moderate bronchitis, we take into account forty milligrams per kg. The girl weighs ten kg, so a single dosage is: forty * ten \u003d four hundred milligrams. 400 mg of amoxicillin is contained in ten milliliters of 200 mg suspension plus 28.5 mg/5 ml or in 5 ml of 400 mg plus 57 mg/5 ml.

Augmentin ® during pregnancy and lactation

In the course of tests on animals conducted in laboratory conditions, it was found that both components penetrate the utero-placental barrier and are determined in min quantities in mother's milk. However, antibiotic therapy with Augmentin ® does not apply to teratogenic factors, because. The drug does not interfere with the embryonic development of the fetus. Augmentin ® during pregnancy is used both orally and parenterally.

In isolated cases in women with a violation of the integrity of the membranes of the fetal bladder before the onset of labor, it was found that preventive therapy with this medication may be associated with inflammation of the small and large intestines (necrotizing enterocolitis) in the newborn. Augmentin ® should be taken only for vital indications.

Antibiotic therapy with Augmentin ® only slightly affects breastfeeding (HB), with the exception of the risk of sensitization.

A woman carrying a child should take into account that almost all antibiotics are poorly tolerated by the body. This pharmacological group has many contraindications and adverse reactions. For example, during treatment, patients often develop candidiasis.

Antibiotic drugs are strong allergens that during pregnancy can cause skin rashes, asthma attacks, and even anaphylactic reactions that threaten the life and health of the mother. In addition, Augmentin ® inhibits the enzymatic activity of the digestive tract flora, which leads to dysbacteriosis. A pregnant woman may experience constipation, diarrhea, abdominal pain and increased gas formation.

Penicillin affects the bone marrow, which causes a violation of hematopoiesis. Aplastic anemia tops the list of serious complications.
Taking Augmentin ® during pregnancy is possible, but only if the therapeutic effect for the expectant mother outweighs the potential risk to the fetus. In the first trimester, it is desirable to find alternative methods of treatment or choose the safest antibiotics.

Side effects and effects when taking Augmentin ®

Adverse drug reactions are listed by frequency of occurrence:

• candidiasis caused by yeast-like fungi of the genus Candida. Taking antibiotics leads to an increase in the population of these yeasts. Yeast-like fungi Candida are part of the normal microflora of the oral cavity, vagina and colon;
• leukopenia, in which patients have general weakness, rapid pulse, subfebrile temperature;
• thrombocytopenia, accompanied by increased bleeding, problems with stopping bleeding, frequent nosebleeds;
• agranulocytosis, the clinical picture of which manifests itself in the form of infection of the body due to a decrease in the effectiveness of the immune response;
• high physical activity and excitability of a person;
• stool disorders (increased bowel movements);
• nausea that occurs when taking high doses;
• antibiotic-associated colitis;
• disease black villous tongue, characterized by hyperplasia of the filiform papillae of the tongue and their keratinization;
• darkening of tooth enamel. Teeth will not change color with proper oral care;
• drug-induced hepatitis, because almost all antibiotics are hepatotoxic;
• increased bilirubin, which is signaled by increased fatigue, yellowness of the skin and mucous membranes;
• high concentration of alkaline phosphatase. Patients complain of loss of appetite and pain in the right hypochondrium;
• intrahepatic cholestasis, accompanied by a lack of bile access to the intestine and a violation of the permeability of the bile capillaries;
• skin rashes diagnosed in patients with individual intolerance and concomitant diseases;
• symptomatic form of polymorphic erythema of toxic-allergic genesis. At the first stages, clearly defined edematous papules of a pinkish hue appear;

Side effects from the liver are more common in males and in elderly patients. The cause of such reactions is often long-term treatment. In childhood, complications from the liver practically do not occur. Most often, side effects are reversible.

The above symptoms make themselves felt during therapy or some time after its completion. The danger is represented by structural and functional disorders of the liver.

Augmentin ® and alcohol

It is well known that antibiotic therapy and alcohol are two incompatible concepts. However, disputes among practitioners on this issue still do not subside. Let's make a reservation right away that ethyl alcohol does not affect the concentration of Augmentin ® in the blood and the therapeutic effect.

It is quite difficult to assess the compatibility and possibility of taking the antibiotic Augmentin and alcohol in parallel, but it is possible to study the effect of drugs on certain organs and systems. The liver suffers the most, which receives a double blow, because it neutralizes toxic substances, which include ethanol and some pharmacological groups.

The use of alcoholic beverages during antibiotic treatment contributes to the development of kidney failure. Moreover, in this case, the age of the patient does not matter, such combinations are deadly for all age groups.

During alcoholic libations, there is a narrowing of blood vessels, which can affect the distribution and transport of the antibiotic.

The load increases not only on the organs of the hepatobiliary system, but also on the digestive organs. A person who simultaneously takes ethanol and Augmentin ® runs the risk of becoming a patient of the gastroenterological department, because. increases the risk of:

• pancreatitis, to which dehydration of the body is added;
• acute hepatitis. A person may feel unwell in the first hours after drinking alcohol;
• erosion of the stomach and intestines. It is dangerous that the disease does not make itself felt for a long time;
• peptic ulcer, manifested by internal bleeding. Alcohol together with Augmentin is capable of initiating the entry of blood into the natural cavity of the body.

Analogues and generics

• Amoxiclav Quiktab ® (from 360 to 600 rubles)
• Amoxiclav ® (from 250 to 550 rubles) -
• Arlet ® (from 230 to 560 rubles)
• Augmentin SR ® (from 650 to 900 rubles);
• Klamosar ® (from 370 to 530 rubles)
• Medoklav ® (from 210 to 310 rubles)
• Panklav ® (from 220 to 520 rubles)
• Ranklav ® (from 390 to 560 rubles)
• Rapiklav ® (from 330 to 450 rubles)
• Flemoklav Solutab ® (from 290 to 870 rubles)

Augmentin ®: reviews of doctors for children and adults

Doctors

Gastroenterologist

Augmentin ® is inexpensive, suitable for the treatment of adults and children. The disadvantages include the fact that the antibiotic is a perishable medicine, and its shelf life is only seven days. In exceptional cases, patients develop antibiotic-associated diarrhea. Protected penicillin does an excellent job of fighting respiratory infections. The suspension has a pleasant taste due to the addition of food additives and flavors.

Dentist

Augmentin ® is an original drug, it fully meets safety standards, is produced in accordance with all quality standards, goes through all stages of purification. The drug helps with systemic infections, when the body is affected by several strains of bacteria. The medication is well tolerated. Clavulanic acid allows you to inactivate a wider range of pathogens.

therapists

Patients rarely complain of complications, but some develop dyspeptic symptoms. Persons receiving Augmentin ® should not forget about fungal infections, which are a faithful companion of long-term antibiotic therapy.

Otolaryngologist

Augmentin ® is suitable for all age groups. Indispensable in the treatment of infections of the ear, nose, lower respiratory tract. Properly selected dosing regimen helps to prevent the occurrence of adverse reactions. In adults, complications are extremely rare. In its effectiveness, it surpasses unprotected penicillins, which are destroyed under the influence of bacterial enzymes.

Augmentin belongs to the combined preparation of the penicillin series from the group of synthetic antibiotics, which have a wide spectrum of action on the body. Before you start using suspensions for children, you must read the instructions for use and study possible contraindications. The drug also has side effects, therefore, if the Augmentin components are incompatible with the child's body, you should stop using it and replace the drug with analogs of an identical action.

General information about the drug

The drug is classified as a broad-spectrum antibiotic. Its use has the following effects:

• prevents the spread of various types of staphylococci, including golden and saprophytic;
• does not allow pertussis bacilli that have entered the body to multiply;
• blocks the access of nocardia, listeria, hemophilic rods, enterorococci, genococci and other bacteria.

Composition and forms of release

Augmentin contains components:

• amoxicillin trihydrate;
• acid represented by a potassium salt.

The drug is sold on the pharmacy market in tablet and powder form. The powder is used to prepare a suspension for oral use. For production, they also take such components, dry flavors, which give a fragrant smell and a pleasant taste of orange and raspberry for the baby. The composition contains succinic acid, silicon and gum.

The powder is contained inside an open bottle, which is placed in a cardboard box. The powder is produced in the UK.

Indications for use

Augmentin is intended for children infected with bacterial viruses that are caused by foreign microorganisms and are sensitive to antibiotics. Thus, the drug is effective in the following diseases:

• with osteomyelitis and infection of bones and bone joints;
• with infections such as periodontitis, severe abscesses and other infectious lesions;
• damage to the skin of an infectious nature, as well as infection of soft tissues;
• detected infections in the pathways of the diaphragm, such as bronchitis, lung abscess, and diagnosing lobar bronchopneumonia;
• when an infection enters the genitourinary system: urethritis, cystitis, pyelonephritis, gonorrhea infection, syphilis infection, infection of the pelvic organs;
• surgical complications in the form of infection - peritonitis.

Suspensions are also used in therapy and for preventive work after infectious complications. Such complications can occur after surgical intervention in the organs of the gastrointestinal tract, head, cervical spine, pelvis, kidneys, heart, joints and bile ducts.

Contraindications and possible side effects

Suspensions of Augmentin should not be used in childhood in the following cases:

• With the appearance of allergic rashes associated with drug therapy, as well as with increased sensitivity to the substances contained in the preparation. In this case, the suspension should be stopped and consult a doctor for advice.
• With the development of icteric phenomena or directly the disease itself jaundice.
• In case of violation of the liver, or failures in its work in the past against the background of medicines containing the substance amoxicillin and clavulanic acid.

The antibiotic does not pose any threat to the body of children. It has been tested for several years and its mechanism of action has been studied quite well. There is a possibility of side effects, but it is very small:

• There may be discomfort in the gastrointestinal tract. The baby may vomit, upset the stomach, or be very sick without gag reflexes.
• allergic manifestations. Anaphylactic shock, dermatitis or vasculitis may occur. Rarely, a child is diagnosed with Stevens-Johnson disease. Allergic rash may appear on the arms and legs, urticaria or erythema may appear.
• Sometimes the baby's weakened body reacts to the components contained in the antibiotic with headache and dizziness.

In some cases, parents may notice a change in the color of the enamel on the child's teeth. This side effect is short lived. A couple of days after the course of treatment with the drug, this effect disappears. The enamel of the child acquires its former color.

How to take and dosage for children

Suspensions of the drug are given to children under 12 years of age. In this case, the child must have a body weight category of at least 40 kg. Three-month-old babies are given a suspension with a special dosage (125 / 31.25 mg). The dosage should be calculated independently based on the body weight and age limit of the child.

For convenience, the finished suspension is measured in the required proportions using a special measuring syringe or cup. Suspension should be taken according to the following rules:

• To reduce irritation of the gastrointestinal tract, the suspension is given to the baby before meals. It must be understood that food does not have any additional effect when taking the drug, therefore, if it is impossible to take the suspension before meals, this can be done at any convenient time.
• It is important to drink the drug in an equal amount of the time interval between doses. When recommended by a doctor, take the drug three times a day, the interval between doses should be 8 hours.

To calculate the dosage rate of the drug, it is necessary to build on the amount of substance content in the suspension:

• Suspension 200 mg: babies weighing 2 to 5 kg should take 1.5 - 2.5 mg of the drug per day, 6 - 9 kg children - 5 ml 2 times a day.
• Suspension 400 mg: children 10-18 kg weight category should receive 5 mg 2 times a day, children from 19 to 28 kg - 7.5 mg twice a day, and children from 29 to 39 kg 2 times a day should receive a dose up to 10 ml.

Suspension 125 mg is divided in more detail:

• children, regardless of age, weighing 2 or 5 kg should consume from one and a half to two and a half ml;
• with a body weight of 6 to 9 kg, up to 5 ml of suspension can be given;
• with a weight category of 10 - 18 kg give 10 ml;
• the weight of the child from 19 to 28 involves taking the drug at a dose of 15 ml;
• with a body weight of 29 to 39, the child should be given at least 20 ml.

For suspensions of 125 mg, the dosage of the drug should be distributed three times a day!

special instructions

Store the drug away from sunlight at a temperature not exceeding 25 degrees. The finished suspension is stored for no more than 7 days at a temperature of 2 - 8 degrees.

Drug analogues

If during the course of taking the drug the child has an allergy or other adverse reactions of the body, then Augmentin is replaced by its analogues: Amoxiclav, Femoklav, Solutab, Ekoklav.

Before using these drugs, you must read the instructions for their use.

Augmentin should be used as directed by your doctor. In case of any side effects, discontinue use. Suspensions can be replaced by the corresponding analogues if necessary.

Augmentin is an antibiotic with a wide spectrum of influence on the body. For effective treatment, a different dosage of this drug is used, which depends on the type of disease and the age of the patient. There are also various forms of release of this antibiotic. If the doctor has prescribed Augmentin, suspensions for children are the best way to take the medicine.

It is believed that during the use of this drug has not lost its effectiveness in the fight against pathogenic microorganisms. For more than a decade and a half, the antibiotic has been coping with the causative agents of many infections, including in babies.

Augmentin is a broad-spectrum antibiotic on the body, as indicated by the instructions for use. It has a complex composition, due to which it effectively fights aerobic and anaerobic bacteria, that is, bacteria that are viable in an oxygen-free environment.

The composition of the drug contains clavulanic acid, which makes the drug highly resistant to beta-lactamase, thereby expanding the spectrum of antibiotic action. Beta-lactamase is an enzyme that makes many strains of microorganisms resistant to penicillins.

The medicine is more effective than other types of antibiotics.

Augmentin is presented in different dosages and types of packaging. Instructions for use contain information that the drug is supplied in tablets with different contents of the active substance - 375 mg and 625 mg. There are also ready-made syrups for oral administration. In addition, you can find a powder intended for injection, packaged in 0.6 grams and 1.2 grams.

For children, doctors most often prescribe a dry substance, from which suspensions are prepared for oral administration. In some cases, drops are made from such a substance.

Augmentin has synonyms, that is, drugs with the same active ingredient, but with a different patented name, which was chosen by its direct manufacturer. The following generic drugs are available on the international drug market:

• Amoxicillin;
• Amoklavin;
• Amoxiclav;
• Clavocin.

Augmentin contains two biologically active components, the dosage of which varies depending on the form in which the drug is produced. These components include clavulanate (in other words, clavulanic acid) and amoxicillin. The dosage of these substances in one scoop of dry powder for dissolving the suspension is as follows: 125 mg of amoxicillin and 31 mg of clavulanate.

Diseases for the indication of Augmentin

Suspension Augmentin for children has many indications for use. The medicinal substance has proven itself very well in the treatment of bronchopulmonary diseases and diseases of the upper respiratory tract in children.

If all recommendations for use are followed, the following therapeutic effect can be observed: in 90% of children pain disappears with pneumonia already on the third day of admission, in 72% of children breathing becomes easier and body temperature stabilizes in infectious diseases of the lungs, bronchi and upper respiratory tract.

A specially selected dosage allows you to quickly achieve positive results in the treatment of severe forms of bronchitis than conventional drugs.

The composition of this drug, which includes 125 mg of amoxicillin and 31 mg of clavulanate in one scoop, allows you to achieve great results in the treatment of sinusitis, tonsillitis, middle ear infections in young children. Urinary tract infections are caused by microorganisms that are not killed by antibiotics without clavulanic acid. This means that Augmentin copes well with such diseases due to its composition.

The instructions for use contain a complete list of diseases for which the Augmentin antibiotic is prescribed. These include:

• inflammation of the mucous membrane of the sinuses (sinusitis);
• acute and chronic inflammation of the palatine tonsils (tonsillitis);
• otitis media;
• bronchial pneumonia;
• exacerbation of chronic bronchitis;
• pneumonia;
• kidney failure;
• urinary tract infections;
• skin infections;
• osteomyelitis.

A broad profile antibiotic is effective in treatment only when an accurate diagnosis is established. Another important condition is the absence of contraindications and individual tolerability of the drug. It is important to get the advice of a qualified doctor and take the drug according to a strictly prescribed scheme.

Dosage of the drug for children

Augmentin is prescribed depending on the body weight of the child, his age, the severity of the infectious disease.

Before you start taking the medicine, you need to make sure that the child's body is not susceptible to allergic reactions and normally tolerates medicinal substances containing clavulanic acid.

Suspensions

When the doctor prescribed Augmentin, a suspension for children would be the best choice. There are two types of powder for diluting suspensions - 400 mg / 57 mg in 5 ml of the finished solution and 200 mg / 28.5 mg in 5 ml. This means that 5 milliliters of a drug that is prepared at home by diluting the dry matter may contain 57 mg or 28.5 mg of clavulanate and 400 or 200 mg of amoxicillin. Accordingly, the dosage of the antibiotic in the drug Augmentin 400 mg is twice as much as in Augmentin 200 mg.

Powder

Sometimes in pharmacies you can find a fruit-flavored syrup powder that is well suited for the treatment of children.

Successful treatment depends on how correctly the doctor has chosen the dosage. Knowing the composition of the drug and the content of active substances in it, you can easily calculate how much suspension, drops, syrup should be given to the baby. In situations where the body is fighting a severe infection, the daily intake of an antibiotic can be doubled. Treatment is carried out no more than 14 days.

Other recommendations for use include the following:

• medication should be taken before meals;
• it is very important not to miss a single dose of the drug, which should be taken at the same time during the day throughout the course of treatment.

Side effects from taking Augmentin

The drug is safe for the child's body. It has been tested over many years, thanks to which the mechanism of its action is very well understood. Of course, side effects may occur, but the likelihood of their manifestation is very low, as indicated by the instructions for use.

Sometimes allergic reactions can occur. Among them: dermatitis, anaphylactic shock, Stevens-Johnson disease, vasculitis. In some cases, there is urticaria, erythema, allergic rash. The child may feel dizzy, severe headache.

From the side of the digestive system, the following negative reactions can be observed: diarrhea, nausea, vomiting. Diarrhea is the most common negative symptom when taking the medicine. When taking a suspension or syrup, the color of the baby's tooth enamel may change, which does not pose a danger to his health.

A complete list of adverse reactions can be found in the annotation to the drug. The instructions for use also contain a complete list of dosages and recommendations on how to properly take a course of treatment with the drug.

To protect the child's body from such unwanted reactions, it is important to strictly observe the dosage of the medicine prescribed by a qualified doctor. It is important to understand that Augmentin 400 mg can replace Augmentin 200 only if the dose is reduced by 2 times. In this case, you can not drink a medicine with an antibiotic content of 400 mg twice a day instead of three doses of Augmentin 200 mg. Unlike prepared suspensions, the syrup contains a reduced dose of amoxicillin - only 125 mg per 5 ml, so if the doctor has prescribed a syrup, it is better not to replace it with a suspension.

What else should be taken during treatment with Augmentin?

Augmentin almost always causes a violation of the intestinal microflora in children. Because of this, such a side effect as diarrhea, nausea, flatulence, dysbacteriosis is manifested. Usually, a doctor in combination with an antibiotic prescribes drugs that normalize the microflora.

The most popular among these drugs are:

• Linex;
• Bifiform;
• Lactobacterin;
• Hilak forte;
• Acylact.

The scheme for taking such medicines is as follows: simultaneously with taking Augmentin at a dosage of 125, 200, 400 mg, 1-2 capsules of Linex or its generic are taken. Children under two years of age are shown taking one capsule 3 times a day, older babies -2 capsules.

Preparations that normalize the microflora may vary, so be sure to study the information contained in the instructions for use. In general, such drugs have a good effect and help the child cope with the consequences of taking antibiotics - they normalize stools, improve appetite, and relieve discomfort in the tummy.

Augmentin is an antibiotic that fights many strains of bacteria. It is suitable even for children in the first year of life. There are various dosages of the antibiotic amoxicillin. For example, in 5 ml of a drug it can contain 125, 200, 400 mg. The dosage depends on the age of the child, the severity of the infection and the weight of the baby.

The article provides an overview of the drug Augmentin (children's antibiotic, formulation - powder for suspension) in dosages of 200 mg / 28.5 mg / 5 ml and 400 mg / 57 mg / 5 ml, an example of calculating the dose of the drug depending on the weight of the child is given.

Suspension Augmenitin is a broad-spectrum antibiotic. It can be given from the first months of life.

Augmentin is an antibiotic that contains two active ingredients. First - amoxicillin, which has an antibacterial effect(but its action is inhibited by some types of microorganisms). To eliminate this shortcoming, the preparation was introduced the second active substance is clavulanic acid. It destroys the protection of microorganisms, which, in its absence, are not amenable to the action of Amoxicillin.

Indications for use

Side effects

After taking Augmentit in children, it often begins due to death. To normalize the stool, give the baby something from this list:

• (three times a day, 1 jar).
• (1 capsule three times a day). If the child does not know how to swallow the capsules, their contents should be poured into a spoon and mixed with water.
• (together with taking an antibiotic, 15-60 drops, depending on age). When the stool returns to normal, the dosage is halved, and they still drink it in a course of 14 days.

Indigestion is a negative consequence after treatment with Augmentit.

Sofia, mother of 5-year-old Gleb, spoke in a review about how to deal with possible nausea caused by taking Augmentin:

“With angina, the doctor prescribed Augmentin in suspension to his son. But after the very first dose, Gleb began to feel sick, and as a result, he vomited. And the son suffers, and there is no benefit. The next day we again went to the clinic to replace the drug. The doctor was surprised by the request and asked to argue it. After listening to complaints, he said that nausea can be managed if the antibiotic is taken strictly before meals. That is, they sat down at the table, drank the suspension - and immediately eat. After such a recommendation, the son no longer felt sick, and the sore throat quickly passed.

Drug analogues

If there was no Augmentin in the pharmacy, then you can buy analogues instead. Let's give a brief overview of them:

1. - a Slovak drug that differs only in the list of excipients.
2. Flemoklav- Dutch analogue, characterized by improved absorption of active substances. Therefore, the effectiveness of treatment with Flemoclav is higher.
3. panclave- medicine of the European production.
4. Rapiclav, Ranklav, Klamosar- cheap analogues can be purchased from Russian and Indian manufacturers. They feature reduced bioavailability, but affordable price.

I will be healthy!

Augmentin is a widely used antibiotic that is effective but sometimes causes diarrhea. Side effects can be eliminated by following the rules for taking the drug and combining it with bacterial therapy. And it is not necessary to go to another pharmacy for Augmentin if you have found any of the analogues. According to the composition of the active ingredients, they are identical, only manufacturers differ.

Alisa Nikitina

Many diseases in children cannot be cured without resorting to antibiotics. Very often, doctors prescribe these potent drugs. A competent parent should know how, when and why the baby should take an antibacterial drug. And to make it easier for you to understand, we have prepared for all occasions.