How to give pyrantel suspension to children. Pyrantel in suspension for children. As a general rule for the prevention of helminthiasis

active substance: pyrantel 0.750 g/15 ml

(in the form of pyrantel embonate 2.1625 g/15 ml).

excipients: sodium benzoate, sodium carboxymethylcellulose, sorbitol 70% (E420), glycerol, magnesium aluminum silicate, polysorbate 80, povidone, apricot flavor, antifoam, citric acid, sodium hydroxide, purified water up to 15 ml.

Description

Suspension of light yellow color with a characteristic odor.

Pharmacotherapeutic group

Anthelmintic drugs, a derivative of tetrahydropyrimidine.

The codeATX:Р02СС01

Pharmacological properties

The drug is used primarily for infections with pinworms. (Enterobius vermicularis) and roundworms (Ascaris lumbricoides).

Can be used for hookworm infection; more effective in treating duodenal hookworm infections (Ancylostoma duodenale), than the American hookworm (Necator americanus).

After oral administration, the drug is poorly absorbed from the digestive tract. After oral administration, it reaches very low plasma concentrations, at the limit of detection. After taking a single dose of the drug at 11 mg/kg body weight, the maximum plasma concentration achieved after 1-5 hours (Tmax) ranged from 0 µg/ml to 0.1 µg/ml.

There are no data on the penetration of the drug through the placenta and into the milk of a nursing woman. The minimum amount of the drug resorbed from the digestive tract is partially metabolized in the liver to N-methyl-1,3-propanediamine.

About 93% of an oral dose of the drug is excreted unchanged in the feces and no more than 7% is excreted in the urine in unchanged form or in the form of metabolites.

Indications for use

Enterobiasis

Ascariasis

Ankylostomiasis

necatoriasis

Contraindications

Hypersensitivity to pyrantel or other components of the drug.

Myasthenia gravis (treatment period).

Simultaneous use of piperazine.

special instructions

Special care must be taken:

in children under 2 years old;

in patients with impaired liver function (the drug may cause a short-term increase in the activity of aspartate aminotransferase - AST);

in malnourished patients and in patients with anemia (anemia).

After taking Pyrantel, laxatives are not prescribed. In the treatment of enterobiasis, all cohabiting persons should be treated simultaneously. To prevent re-infection, it is necessary to strictly observe the rules of hygiene (wash hands, cut and clean nails, avoid scratching the perineal area, change bed and underwear daily).

The suspension contains sorbitol. Do not use the drug in patients with rare hereditary fructose intolerance. Sorbitol may have a mild laxative effect.

Interaction with other drugs

May increase the concentration of theophylline in plasma.

The simultaneous use of piperazine inhibits the action of pyrantel.

Use during pregnancy and lactation

Adequate and strictly controlled safety studies of the use of pyrantel during pregnancy and lactation (breastfeeding) have not been conducted. The use of the drug during these periods is possible only if absolutely necessary, if the intended benefit to the mother outweighs the potential risk to the fetus or child, and only under strict medical supervision.

The use of the drug in the elderly

There is no information on the effect of age on the action of Pyrantel in geriatric patients.

Influence on the ability to drive vehicles and control mechanisms

Given the possible side effects from the nervous system (dizziness, headache, etc.), during the use of the drug, care must be taken when engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Dosage and administration

Mode of application

The drug should be taken orally, during or after a meal, with water.

Shake before use until a homogeneous suspension is obtained.

There is no need to take laxatives before using Pirantel.

A graduated measuring cup is included with the package for easy dosing.

5 ml of suspension (1 scoop) contains 250 mg of pyrantel.

– With ascariasis

Adults and children weighing > 10 kg: single dose of 11 mg/kg. Usually a single dose is prescribed, but if there is no effect, the dose should be repeated after 2 or 3 weeks.

– With enterobiasis

Adults and children weighing > 10 kg: single dose of 11 mg/kg. This dose of the drug should be repeated after 2 or 3 weeks.

– With invasion by duodenal hookworm or someatorus

Adults and children weighing > 10 kg: 11 mg/kg once daily for 3 days.

Below is the dosage of Pirantel suspension depending on body weight:

Dosing in patients with hepatic impairment

In case of existing liver diseases, the doctor should be informed.

Dosing in patients with impaired renal function

In case of existing kidney disease, the doctor should be informed.

Overdose

Following an overdose of the drug, the following symptoms may develop: visual disturbances, confusion, dizziness, fainting or feeling dizzy when rising from a lying or sitting position, increased sweating, never felt tired or weak before, irregular heartbeat, convulsions, tremors and muscle weakness, exhaustion , breathing problems, loss of consciousness.

In case of intoxication, you should immediately consult a doctor.

Side effects

Side effects of pyrantel are rare and disappear after treatment is stopped.

The frequency of adverse reactions is defined as follows: very frequent (≥ 1/10); frequent (≥ 1/100 and

Nervous system disorders:

Rare: headache, dizziness, drowsiness or insomnia

Not known: hallucinations, confusion, paresthesias

Hearing disorders and labyrinth disorders:

With unknown frequency: hearing loss

Gastrointestinal disorders:

Rare: nausea, vomiting, abdominal pain, diarrhea and loss of appetite

Not known: urge to defecate

Liver and biliary tract disorders:

Rarely: a transient increase in the activity of aminotransferases (enzymes that determine liver function).

Terms of dispensing from pharmacies

Without recipe.

Package

15 ml in dark glass bottles with a polyethylene cap with a guarantee ring.

1 bottle with leaflet and measuring cup in a cardboard box.

Manufacturer's name and address

Medana Pharma A. O.

98-200 Sieradz, st. V. Loketka 10, Poland

If you are not sorry to stuff your child with chemical synthetic compounds, then this article is just for you.

Drug Pirantel is available in suspension and is used for children as a means of expelling worms.

Below you can read the instructions for use, set out "in your own words."

How does it work?

Suspension Pirantel it is also convenient because it does not require any special preparation of the child for its reception, and the worms do not move through the intestines so quickly, which makes the effect of the drug softer. By the way, after using the drug, no additional manipulations are required for the final removal of paralyzed worms from the intestines. At least that's what the instructions say.

Parents should be aware that the active substance of Pirantel is absorbed into the blood and decomposed in the liver. Draw your own conclusions.

When do doctors prescribe Pirantel suspension to children?

Small children often mess around in sand and earth, and from dirty hands, helminths very easily enter their bodies. Therefore, it is not surprising that it is in childhood that infection with worms occurs most often. Pirantel is recommended for getting rid of round worms, that is, for the treatment of enterobiasis, ankylostomiasis, necatoriasis and ascariasis. To avoid re-infection, all family members should be treated at the same time as the child. In addition, you need to periodically carry out wet cleaning and cleaning of all clothes.

The effectiveness of Pirantel in trichocephalosis is not so pronounced (the causative agent is whipworm).

Contraindications for use

As for the contraindications to the use of the suspension by children, it must be said here that the instructions for use prohibit its use in case of severe damage to the nervous system with an increase in muscle weakness, with individual intolerance to the drug and at the age of up to 6 months.

Dosage

Pirantel suspension should be given to children immediately after or during meals 1 time per day. The dosage is calculated individually, based on the age and weight of the child.

Usually prescribed once 10 mg per kilogram of the child's weight. It turns out that if the child weighs less than 75 kg, then the standard dose is 750 mg, or 3 scoops of the suspension (15 mg). If the weight is greater, then the dose is increased to 1000 mg, or 4 scoops of the suspension (20 mg).

Very young children 1.5-2 years old should be given 125 mg of suspension, or half a spoonful (2.5 mg); children 2-6 years old - 250 mg, or 1 scoop (5 ml); children 6-12 years old - 500 mg, or 2 scoops (10 ml).

If the doctor has diagnosed ankylostomiasis, he usually prescribes the same dose, but you need to drink for three days in a row. If the diagnosis necatorosis- the dose is doubled and the course of administration continues for 2 days.

The instruction also warns that it is impossible to take Pirantel and another antihelminthic drug, for example, Decaris, at the same time. The instructions also list side effects from taking Pirantel.

• Date: 03/17/2017
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Instructions for use for Pirantel suspension for children contain basic information regarding the effective and safe use of this anthelmintic drug in the treatment of young patients. How to give Pirantel to a child? What are the indications and contraindications? What adverse reactions can provoke this drug and its analogues?

Pirantel is produced in the following forms:

1. Tablets (intended for adult patients).
2. Suspension (suitable even for newborn babies).

As a rule, a tablet preparation for combating helminths in young patients is not used, and the suspension has a milder effect and does not require special preparation of the baby to take the drug.

The description indicates that this medication has not only therapeutic, but also preventive properties. Tablets can be prescribed to small patients over 2 years of age, but they should be used with extreme caution and only on the advice of a qualified pediatrician.

Children's Pirantel is designed specifically for young patients. The drug acts more gently, as a result of which the helminths move along the gastrointestinal tract more slowly. In addition, the suspension can be given to children from the first months of their life, while the drug in tablet form must be chewed, so it is unsuitable for infants.

When are they assigned?

1. Ascariasis.
2. Necatorosis.
3. Enterobioses.
4. Ankylostomiasis.
5. Trichocephalosis.

Helminthiases are often accompanied by characteristic symptoms. Therefore, it is possible to give Pirantel from worms for children in case of manifestation of painful symptoms, such as:

• nausea;
• bouts of vomiting;
• bronchitis;
• permanent lack of appetite;
• pain in the abdomen;
• drastic weight loss.

If a child has problems with appetite, he becomes moody, sleeps poorly and grinds his teeth in a dream, then this may indicate the presence of helminthiasis. In this case, Pirantel or its analogues may be recommended. In addition, this medication can be used for prophylactic purposes.

When is it contraindicated?

According to experts, Pirantel in the form of a suspension is not recommended for giving to a child if there are the following contraindications:

1. Individual intolerance and hypersensitivity to active substances.
2. Violations in the functioning of the nervous system, accompanied by muscle weakness.
3. Liver failure.

An appropriate indication from a qualified pediatrician is also required in order to give a suspension to babies who have not reached six months of age.

Tablets are contraindicated in small patients under the age of 2 years, as well as children with the following health problems:

• hepatic pathologies;
• increased susceptibility to allergic reactions;
• myasthenia.

Before starting a therapeutic course, it is imperative to consult with a pediatrician to identify possible limitations and contraindications to the use of Pirantel in the baby.

What adverse reactions can cause?

Reviews of doctors and parents of young patients indicate that in most cases Pirantel is well tolerated by the children's body. Sometimes during the therapeutic course, side effects of the drug may occur:

• nausea;
• bouts of vomiting;
• general weakness of the body;
• bouts of dizziness;
• headache;
• sleep disorders;
• the appearance of skin rashes of an allergic nature;
• drowsiness during the daytime;
• increase in body temperature;
• diarrhea;
• hives.

About overdose

The optimal dose of Pirantel should be calculated by a specialist on an individual basis, taking into account the age category of the baby and his body weight. Otherwise, there is a high chance of an overdose. In large quantities, Pirantel and its analogues can cause the following painful symptoms in babies:

• nausea;
• diarrhea;
• bouts of vomiting;
• stomach upset;
• lack of appetite.

Cases of severe poisoning are possible if an excessively large amount of syrup is taken. In such situations, small patients do gastric lavage and prescribe activated charcoal.

How to take Pirantel for children, what dosage is needed, the attending physician will tell you. Preliminary consultation with a specialist will help to avoid accidental overdose and the development of other undesirable reactions.

Features of the use of suspension and tablets

How many days should the therapeutic course last? This question interests many parents. Pediatric specialists recommend continuing treatment for 1 or 2 days. If necessary, the therapeutic course can be repeated after a mandatory 3-week break.

Pirantel for prevention is usually taken 1 time per day. It is recommended to give the baby a suspension during a meal or immediately after the child eats.

During the therapeutic course, it is not advised to use enterosorbents and antihistamines, since they significantly reduce the effectiveness of anthelmintic drugs.

Pirantel tablets are allowed to be prescribed to babies from the age of 2 years. However, many experts do not recommend using them for the treatment of children under 6 years of age. This is due to the fact that the tablets must be thoroughly chewed before swallowing, and a small child may simply accidentally choke on the medicine. In addition, the product does not have a very pleasant taste, and getting the baby to chew it and then swallow it can be very problematic.

The daily dosage of Pirantel tablets for small patients is calculated by the attending physician, taking into account the age category, body weight and individual characteristics of the child.

How often can babies take Pirantel? This question worries many parents of young patients. The answer to it depends on the indications for the use of the drug. So, for preventive purposes, Pirantel is recommended for babies to give no more than 1 time per year.

For medicinal purposes, in case of manifestation of characteristic symptoms, the drug is taken as prescribed by the doctor. A repeated prophylactic course can be carried out no earlier than after a six-month break.

In diseases such as enterobiasis or ascariasis, therapy is advised to be repeated 3 weeks after the completion of the main treatment course. Therefore, only a qualified specialist on an individual basis can accurately answer questions regarding the frequency of taking this anthelmintic agent.

Pirantel is an effective anthelmintic drug, one of the few approved for the treatment of the smallest patients. Most parents are interested in what can replace Pirantel if necessary? Doctors distinguish the following acceptable analogues:

1. Decaris.
2. Nemocide.
3. Helmintox.

Pirantel for children is an effective and safe remedy in the fight against helminthic invasion. Treat the baby with Pirantel should be prescribed by a doctor, strictly following the recommendations of a specialist regarding the dosage and duration of the therapeutic course.

Reviews about the drug

Anastasia, 25 years old

Irina, 22 years old

When my son got worms, according to the doctor's prescription, they began to give him Pirantel syrup. The effect was positive, but during the treatment the baby felt bad: he felt sick, his stomach ached, his temperature rose. This condition lasted for a couple of days, then passed. The doctor said that this was due to the process of cleansing the body of worms.

Inna, 30 years old

Mom with two children. The eldest son is 8 years old, the youngest is 5 months old. During the medical examination, it turned out that both boys were infected with worms. The pediatrician advised Pirantel and helped to calculate the safe dosage for children. Very satisfied with the drug. Now we take it with the whole family for prevention.

Comments

Megan92 () 2 weeks ago

Daria () 2 weeks ago

Previously, they poisoned themselves with chemicals such as Nemozoda, Vermox. I had terrible side effects: nausea, impaired stool, my mouth was covered, as with dysbacteriosis. Now we are taking TOXIMIN, it is much easier to tolerate, I would even say no side effects at all. good remedy

P.S. Only now I myself am from the city and did not find it in pharmacies, I ordered it via the Internet.

Megan92 () 13 days ago

Daria () 12 days ago

Megan92, I already indicated) Here I am attaching again - TOXIMIN official website

Rita 10 days ago

Isn't this a divorce? Why sell online?

Yulek26 (Tver) 10 days ago

Rita, you seem to have fallen from the moon. In pharmacies - grabbers and even want to make money on it! And what kind of divorce can there be if payment after receipt and one package can be received free of charge? For example, I ordered this TOXIMIN once - the courier brought me, I checked everything, looked and only then paid. At the post office - the same thing, there is also a payment upon receipt. And now everything is sold on the Internet - from clothes and shoes to appliances and furniture.

Rita 10 days ago

Sorry, I didn't notice at first the information about the cash on delivery. Then everything is in order for sure, if the payment is upon receipt.

Elena (SPB) 8 days ago

I read the reviews and realized that I should take it) I'll go to place an order.

Dima () A week ago

Instructions for medical use

medicinal product

PIRANTEL

Tradename

Pirantel

International non-patent name

Pirantel

Dosage form

Oral suspension, 250 mg/5 ml

Compound

1 ml suspension contains

active substance - pyrantel 50.000 mg

(in the form of pyrantel embonate 144.000 mg),

Excipients: sodium benzoate, sodium salt of carboxylated methylcellulose, sorbitol 70%, glycerin, magnesium aluminum silicate, polysorbate-80, povidone, simethicone emulsion, citric acid monohydrate, sodium hydroxide, apricot flavor, purified water.

Description

Suspension of light yellow color with a characteristic odor.

Separation into a liquid layer and sediment is allowed, after shaking a homogeneous suspension is formed.

Pharmacotherapeutic group

Anthelmintic drugs. Tetrahydropyrimidine derivatives. Pirantel.

ATX code R02 SS 01

Pharmacological properties

Pharmacokinetics

Pyrantel embonate is practically insoluble in water, and is slightly absorbed from the digestive tract, after taking a single dose of 10 mg / kg of body weight, the concentration of the drug in blood plasma is 0.005-0.13 μg / ml for 1-3 hours.

About 7% is excreted in the urine in unchanged form (0.2-1.6%) and partially in the form of metabolites (0.8-5.6%). Metabolized in the liver, the main metabolite is N-methyl-1,3-propanodiamine. About 93% of the drug taken orally is excreted unchanged through the intestines.

Pharmacodynamics

Can be used for hookworm infection; has a more effective effect in the treatment of ankylostomiasis than in the treatment of necatoriasis.

Indications for use

Enterobiasis

Ascariasis

Hookworm

necatoriasis

Dosage and administration

Inside during or after a meal.

Depending on the age and body weight of the patient, the following doses are used:

With ascariasis

5 mg Pyrantel per 1 kg of body weight, once.

With hookworm longer treatment:

10 mg/kg body weight per day for 3 days or 20 mg/kg body weight

per day for 2 days, once

5 ml of suspension (1 scoop) - contains 250 mg of pyrantel.

Shake before use until a homogeneous suspension is obtained.

There is no need to use laxatives.

With enterobiasis, the whole family is treated.

The drug is usually well tolerated.

Rare (>1/10,000,<1/1 000)

Appetite disorders, nausea, vomiting, abdominal pain, diarrhea

Headache, dizziness, drowsiness, insomnia

Skin rash

Asthenia, elevated liver enzymes

In isolated cases

Tenesmus, hallucinations with disorientation, paresthesia, fever, hearing loss

Contraindications

Hypersensitivity to the components of the drug

Concomitant use of piperazine

Myasthenia gravis (treatment period)

Drug Interactions

May increase the concentration of theophylline in plasma.

Pyrantel should not be co-administered with piperazine, as these drugs are antagonists.

special instructions

Use with caution in children under 2 years of age, in the presence of anemia, in malnourished patients, and in case of impaired liver function (causes a temporary increase in the level of aspartate transaminase).

In the treatment of enterobiasis, all cohabiting persons should be treated simultaneously. Careful observance of hygiene (cleaning of residential premises and cleaning of clothes to destroy helminth eggs) serves as a prevention of reinfection.

Due to the fact that the drug contains a solution of sorbitol, it should not be administered to patients with rare heredity of fructose intolerance. The drug may have a mild laxative effect.

Pregnancy and lactation

Animal studies have not shown a negative effect of pyrantel on the fetus. However, due to the lack of controlled studies on the use of pyrantel during pregnancy, the drug should be prescribed to pregnant women only if the expected benefit to the mother outweighs the potential risk to the fetus.

Data on the use of pyrantel in lactating women is not available.

The appointment of pyrantel to women who are breastfeeding is not recommended. If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Features of the influence of the drug on the ability to drive a vehicle and potentially dangerous mechanisms

Studies of the effect of the drug on the ability to drive vehicles and maintain mechanical equipment have not been conducted.

Overdose

Symptoms: blurred vision, confusion, dizziness, fainting or feeling dizzy when rising from a lying or sitting position, increased sweating, never felt tired or weak before, irregular pulse, muscle spasms, tremors and weakness, exhaustion, asphyxia (difficulty breathing, loss of consciousness) .

Treatment: there is no specific antidote. In case of an overdose, symptomatic and supportive measures should be taken: gastric lavage, use of laxatives, ensuring airway patency and respiratory support, maintaining blood pressure levels.

Release form and packaging

15 ml of the drug is placed in orange glass bottles with polyethylene caps.

1 bottle, together with a measure with a scale and instructions for use in the state and Russian languages, is placed in a cardboard box.

Storage conditions

Store below 25°C. Protect from light.

Keep out of the reach of children!

Shelf life

Shelf life after the first opening of the package - 21 days

Do not use after the expiration date.

Terms of dispensing from pharmacies

On prescription

Name and country of the manufacturing organization

Medana Pharma JSC

98-200 Sieradz, st. V.Loketka 10, Poland

Name and country of the marketing authorization holder

Himfarm JSC, Kazakhstan

Name and country of the packaging organization

Medana Pharma JSC, Poland

Address of the organization accepting claims from consumers on the quality of products (goods) on the territory of the Republic of Kazakhstan

JSC "Khimfarm", Shymkent, Republic of Kazakhstan,

st. Rashidova, 81

Phone number 7252 (561342)

Fax number 7252 (561342)

Last update of the description by the manufacturer 27.07.2004

Filterable List

Active substance:

ATX

Pharmacological group

Nosological classification (ICD-10)

3D images

Composition and form of release

in dark glass bottles of 15 ml (with measuring cap); in a pack of cardboard 1 bottle.

Description of the dosage form

Suspension of light yellow color with a characteristic odor.

pharmachologic effect

Blocks neuromuscular transmission in sensitive helminths.

Pharmacodynamics

It acts on helminths in the early phase of development and on mature forms, does not affect larvae in the migration stage. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis.

Pharmacokinetics

Practically not absorbed in the gastrointestinal tract. After ingestion in a single dose of 10 mg/kg of body weight, Cmax is 0.005-0.13 μg/ml and is achieved within 1-3 hours. Partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted in the faeces (50% of the dose taken - unchanged) and in the urine (about 7% - unchanged and as a metabolite).

Indications for Pirantel

Enterobiasis, ascariasis, ankylostomiasis, necatoriasis.

Contraindications

Hypersensitivity.

Use during pregnancy and lactation

Use during pregnancy and lactation is possible only under the strict supervision of a physician.

Side effects

From the nervous system and sensory organs: rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing loss, hallucinations, confusion, paresthesia.

From the digestive tract: nausea, vomiting, diarrhea, stomach pain; rarely - increased activity of hepatic transaminases.

Others: skin rash, fever.

Dosage and administration

inside, during or after a meal.

Enterobiasis, ascariasis and mixed invasions: once 10 mg/kg.

Ankylostomiasis: 10 mg/kg/day for 3 days.

Necatoriasis: 20 mg/kg for 2 days (for severe forms).

Precautionary measures

With enterobiasis, simultaneous treatment of cohabiting persons should be carried out. After completion of treatment, it is necessary to conduct a control study of feces for worm eggs.

Storage conditions for Pirantel

Keep out of the reach of children.