Folic acid 100 mg tablets 50. How to take Folic acid for medicinal purposes? Folic acid and vitamin E: regimen

Last update of the description by the manufacturer 24.04.2018

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Nosological classification (ICD-10)

Compound

pharmachologic effect

Action on the body

Due to its constituent components, Fertin contributes to the correction of metabolic disorders that underlie ovarian dysfunction in women and spermatogenesis in men.

Fertina can have a positive effect on reproductive function in women, because. its components help to normalize ovarian function, improve the quality of oocytes and restore the menstrual cycle. Fertina can be used as an adjuvant for polycystic ovary syndrome (PCOS), as well as in assisted reproductive technology (ART) protocols.

Fertina may have a positive effect on reproductive function in men with infertility participating in preconception programs and IVF programs.

Fertina can be used as an adjuvant for insulin resistance and type 2 diabetes.

Fertina can be used as an aid in the elimination of androgenic disorders in women, manifested by hirsutism, acne, excessive greasiness and hair loss, and androgenic obesity.

Component properties

Inositol(Myo-Inositol, Vitamin B 8). It is a vitamin factor of group B. The largest amount of inositol contains citrus fruits, whole grains, dried fruits, peanuts, wheat germ, beans, yeast, vegetable greens. Fruits and fresh vegetables contain more inositol than frozen, canned, and pickled foods.

Inositol has shown its benefits in patients with menstrual irregularities. Taking inositol for 6 months allowed to reduce the number of anovulatory cycles by 4 times. This effect is associated with the positive effect of inositol on the processes in the ovaries, in which LH and FSH are involved (Venturella R. et al. Assessment of the modification of the clinical, endocrinal and metabolical profile of patients with PCOS syndrome treated with myo-inositol (ital. ) //Minerva ginecologica.-2012.-Vol.64, n.3.-P.239-243.).

Inositol has shown positive results when administered as part of preconception preparation before ART. Inositol improved the functional state of oocytes in patients with PCOS in ART protocols (Papaleo E. et al. Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. (English) // Fertility and sterility. - 2009. - Vol. 91, n. 5. - P. 1750-1754.). The addition of inositol to folic acid in patients without PCOS undergoing superovulation stimulation cycles in IVF protocols allows, without reducing the number of clinical pregnancies, to reduce the number of mature oocytes used and to reduce the dosage of recombinant FSH, which may reduce the risk of developing ovarian hyperstimulation syndrome (Lisi F. et al. Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study // Reproductive biology and endocrinology RB&E -2012 - Vol. 10 - P. 52.

The appointment of inositol to men as part of ART can improve the quality of seminal fluid, increase the percentage of motile spermatozoa with a high mitochondrial membrane potential (Condorelli R.A. et al. Myoinositol: does it improve sperm mitochondrial function and sperm motility? // Urology. -2012. Vol. 79, n. 6.-P. 1290-1295.).

The results of randomized clinical trials allow us to recommend the use of inositol to improve ovarian function, as well as correct metabolic and hormonal disorders in PCOS (Unfer V. et al. Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials. (eng. ) // Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology. -2012. - Vol. 28, n. 7. - P. 509-515).

Hyperinsulinemia characteristic of PCOS with preserved sensitivity of ovarian tissues to insulin leads to the development of hormonal disorders, an increase in the amount of androgens, which manifests itself as hirsutism, acne, and androgenic obesity. Inositol may contribute to the elimination of androgenic disorders. Patients treated with inositol demonstrated a decrease in LH, prolactin, testosterone, plasma insulin, LH/FSH ratio, restoration of insulin sensitivity (glucose/insulin ratio and HOMA index), menstrual function, and hirsutism and acne decreased after 6 months therapy (Artini P.G. et al. Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study (English) // Gynecological Endocrinology: the official journal of the International Society of Gynecological Endocrinology. -2013. - Vol. 29, n. 4. -P. 375-379 Zacché M. et al Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome // Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology - 2009 - Vol. 25, n. 8 - P. 508-513). Another study demonstrated a significant reduction in triglycerides, insulin, and restoration of ovulation (Costantino D. et al. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. (English) //European review for medical and pharmacological sciences - 2009 - Vol. 13, n. 2 - P. 105-110).

Inositol reduces the risk of developing insulin resistance, diabetes, overweight and obesity by indirectly increasing the sensitivity of insulin receptors and stimulating the processing of carbohydrates and fats to support the energy metabolism of the cell. In patients with gestational diabetes, inositol supplementation led to a decrease in fasting insulin and glucose levels (Corrado F. et al. The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes. (English) // Diabetic medicine: a journal of the British Diabetic Association.-2011.-Vol.28, n.8.-P.972-975).

Folic acid. It is a water-soluble vitamin of group B (vitamin B 9). Folic acid plays an important role in amino acid metabolism, protein and nucleic acid synthesis (primarily in the production of DNA and RNA), and chromosome repair. Therefore, it is very important for normal cell division and tissue growth.

Folic acid is found in large leafy green vegetables, liver, eggs and legumes, while its content in fruits (with the exception of oranges), meat and milk is quite low.

During cooking, it is almost completely destroyed to folate (90%) in just a few minutes.

With a deficiency of folic acid in the period of preparation for pregnancy and during pregnancy, egg pathology, placental abruption (both partial and absolute), miscarriage, spontaneous abortion (miscarriage), congenital malformations in a child can develop: anencephaly, neural tube defect, hydrocephalus , hypotrophy, cleft lip, mental retardation, anemia, which can lead to fetal hypoxia (see. http://www.vse-pro-children.ru).

Folic acid practically does not accumulate in the human body, therefore, to prevent complications during pregnancy and the development of defects in the nervous system of the fetus, it is advisable to take folic acid even at the stage of pregnancy planning.

As a food supplement, an additional source of inositol and folic acid.

Contraindications

Individual intolerance to the components.

Dosage and administration

pharmachologic effect

Replenishes folic acid deficiency, stimulates erythropoiesis.

Folic acid - folacin, water-soluble folate, vitamin B9. In the body, it is converted into tetrahydrofolic acid, which is necessary for the maturation of megaloblasts and their transformation into normoblasts. With its deficiency, a megaloblastic type of hematopoiesis develops. It occupies an important place in the metabolism of purines and pyrimidines, the synthesis of nucleic acids, the metabolism of amino acids (glycine, methionine and histidine). After ingestion, folic acid, combining in the stomach with the internal factor of Castle (a specific glycoprotein), is absorbed in the upper part of the duodenum. Almost completely bound to plasma proteins. It undergoes activation in the liver under the influence of the enzyme dihydrofolate reductase, turning into tetrahydrofolic acid. Cmax in the blood is achieved in 30-60 minutes. It is excreted by the kidneys both unchanged and as metabolites.

Indications

Megaloblastic anemia, sprue, drug and radiation anemia and leukopenia, post-resection anemia, chronic gastroenteritis, intestinal tuberculosis, folic acid deficiency.
Prevention of folic acid deficiency in the body (including during pregnancy and lactation).

special instructions

In pernicious anemia, folic acid should only be used in conjunction with cyanocobalamin, since folic acid, by stimulating hematopoiesis, does not prevent the development of neurological complications (including funicular myelosis). Long-term use of folic acid (especially in high doses) is not recommended due to the risk of reducing the concentration of cyanocobalamin in the blood.

Compound

1 tablet contains folic acid 1 mg.

Dosage and administration

For therapeutic purposes, adults - 5 mg / day; children - in smaller doses depending on age. The course of treatment is 20-30 days.
For the prevention of folic acid deficiency in the body, it is used in doses of 20-50 mcg / day.

The daily requirement for folic acid is for children 1-6 months - 25 mcg, 6-12 months - 35 mcg, 1-3 years - 50 mcg, 4-6 years - 75 mcg, 7-10 years - 100 mcg, 11- 14 years - 150 mcg, 15 years and older - 200 mcg.
During pregnancy - 400 mcg / day, during lactation - 300 mcg / day.

Side effects

Allergic reactions: bronchospasm, erythema, fever, skin rashes.

drug interaction

With simultaneous use with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid decreases.
With simultaneous use, folic acid reduces the effects of phenytoin, primidone, PAS, sulfasalazine, hormonal contraceptives for oral administration, chloramphenicol.
Folic acid increases the metabolism of phenytoin.

Folic acid is one of the vital vitamins. As a rule, there is not so much of it in the usual diet, so vitamin B9 deficiency is far from uncommon. To replenish the balance, you need to know the correct dosage of folic acid and be able to properly use additional folates.

Vitamin B9 (medical name - folic acid) is one of the most important nutrients for humans, which is needed for many processes in the body. Folic acid helps cells grow, maintain the integrity of DNA, so the vitamin prevents the development of cancer.

In addition, folic acid is involved in hematopoiesis, helps the heart and blood vessels. By improving blood circulation, acid has a beneficial effect on immunity, improves the functioning of the nervous system and the general condition of the body.

BY THE WAY
Our intestines can produce folic acid on its own, but in very small amounts, so the bulk of this vitamin must come from food.

Reception features

Like any other drug, folic acid should be taken regularly. At the same time, consider its interaction with other drugs. For example, acid reduces the effect of phenytoin, therefore, its dose must be increased.

A number of substances reduce the absorption of folic acid by the body:

• Antacids
• cholestyramine,
• some antibiotics (sulfonamides, chloramphenicol, tetracyclines, neomycin, polymyxin)

Reduce the effect of the action can also:

• cytotoxic drugs ( Methotrexate),
• antibacterial agents (pyrimethamine),
• diuretics (Triamterene).

With this option, doctors prescribe calcium folinate instead of folic acid.

How to take for prevention

For prophylaxis, small daily doses of B9 are used: 400 mcg for adult.

Teenagers this dosage may be prescribed for the prevention of anemia, immunodeficiency, and physical retardation.

Women planning a pregnancy, it is recommended to use 1 mg of acid once a day for medicinal purposes for six months in order to reduce all kinds of fetal malformations.

When is the best time to take

"Folk" must be taken orally after meal, as indicated in all instructions for the drug.

The fact is that taking vitamins on an empty stomach can lead to irritation of the gastric mucosa: like other acids, folic acid increases its acidity. This provokes diseases of the stomach - gastritis, ulcers, etc.

If you take a vitamin while eating, food will be more difficult to digest, since the acid forms an insoluble complex with zinc.

Important: if you miss a pill, you do not need to take a double dose

Admission courses

To maintain optimal levels of folic acid in the body, a daily intake is necessary.

ADVICE:
It is better to drink any vitamins in the morning during breakfast, drinking plenty of fluids. So unabsorbed vitamin surpluses can be easily removed by the body

How many folic acid tablets per day should I take

The number of tablets depends on the mass of the active substance in it, since folic acid is now sold in different dosages.

Most often, pharmacies sell folic acid in a dosage of 1 mg. For medicinal purposes, you need to use 1-2 tablets. per day. Pregnant women - 1 tablet per day for prevention.

Folic acid and vitamin E: regimen

Vitamin E and folic acid - a couple of useful elements that complement each other. Most often, gynecologists prescribe this combination of vitamins to girls from the first stages of pregnancy or to those who are just planning it.

Vitamin E and B9 guarantee the full development of the internal organs of the child and the development of the central nervous system. Vitamin E is directly responsible for the reproductive system, increases the fertility of the girl, reduces the threat of miscarriage in the short term, and prevents the placenta from exfoliating.

When used with folic acid, the intestinal wall is strengthened, the mother's condition improves: working capacity increases, immunity increases, the nervous system is restored.

Optimal dosage:

• Vitamin B9 (folic acid) - 0.8 mg per day.;
• Vitamin E (tocopherol) - 0.3 mg per day..

Is it possible to drink folic acid without a prescription

Any pharmacy will tell you that this medicine is available without a doctor's prescription.

If you find yourself deficient in folic acid, then the smallest daily dose will not harm you, since the excess is excreted by the body on its own.

The best option is dietary supplements, where the composition already contains folic acid. Like vitamin complexes, dietary supplements contain many other useful substances.

ADVICE :
The daily volume of folic acid is determined by various factors: gender, age, lifestyle and body condition; Only a doctor can help you choose.

Despite the widespread belief that folate is easily excreted from the body and its overdose is impossible, it should be borne in mind that the vitamin has a number of contraindications:

• hypersensitivity to B9,
• malignant anemia,
• oncology,
• vitamin B12 deficiency.

Release form

Folic acids in pharmacies can be found in the form of powders or tablets (usually 1 mg, 25 and 50 pieces per pack).

However, there are other forms of release:

100 mcg

• the minimum dosage may be prescribed by a doctor for prevention;
• 100 mcg is how many mg: 0.1 mg

400 mcg

• dosage in tablets 400 mcg:
  1 tab. per day (if there is no deficiency), or half a tablet (1/2 tablet of acid) at a dosage of 1 mg per day - for children over 4 years old and adults as maintenance treatment; pregnant women to prevent fetal defects
• 400 mcg is how many mg: 0.4 mg;
• folic acid 400 mcg how many tablets:
  1 tab. a dosage of 400 mcg or a quarter of a tablet with a dosage of 1 mg is the recommended daily dose for women of childbearing age and during pregnancy.

800 mcg

• dosage in tablets 800 mcg:
  1 tab. or slightly less than 1 tab. a dosage of 1 mg is prescribed during pregnancy and lactation.
• 800 mcg is how many mg: 0.8 mg

1 mg

• dosage in tablets 1 mg:
  1 tab. for the treatment of anemia, pregnant women - from 1.2 to 2.5 tab. per day in the first trimester.
• 1 mg is how many mcg: 1000 mcg

4 mg

• dosage in 4 mg tablets:
  attributed when planning pregnancy. There is no need to be afraid of such doses: if the doctor has prescribed this volume for you, then you or your baby do not have enough B9

5 mg

• dosage in tablets 5 mg:
  adults 1 tab. per day for the treatment of beriberi, children - in smaller doses depending on age
• 5 mg is how many grams: 0.005 g

Dosage of folic acid for children

Folic carbon dioxide is necessary for the growth and proper development of the body, because the body's immunity is developed directly in childhood, the main life-supporting systems are formed, so it is important to give the child all the necessary vitamins for its construction.

baby

Infants are recommended 25 micrograms of folic acid each day. With normal development, the baby receives all the nutrients from mother's milk, but if the doctor has identified a lack of nutrients in the newborn, B9 is prescribed additionally. Often, folic acid is required for premature babies.

Teenager

At a transitional age, B9 is necessary for children for the normal course of sexual development: vitamin B9 helps the young body to establish hormonal balance. In adolescence, many face skin problems of the face and body: acne, pimples, redness. With the help of folic acid, you can fight redness and irritation of the skin.

For the prevention of vitamin deficiency, children at this age are recommended to use 150-200 mcg, this is half a tablet with a dosage of 400 mcg. But we must remember that if the body needs to be restored, then the therapeutic dose of acid is determined by the doctor.

schoolboy

Folic acid for school-age children from 6 to 10 years old is prescribed at a dosage of 100 mcg per day; from 10 to 14 years - 150 mcg.

Schoolchildren need vitamin B9 to regulate brain activity in order to help children cope with the study load and relieve emotional stress.

How much folic acid do children need: summarizing

Daily Value for Women

To maintain the balance of vitamins in the body, an adult woman needs to take at least 400 micrograms of folate per day.

In addition to the fact that vitamin B9 strengthens the body, normalizes internal processes and improves the general condition, folic acid (folka, as mothers like to call it) is of particular importance for women:

• beneficial effect on the reproductive organs,
• stops hair loss, rejuvenates and tones the skin;
• normalizes the hormonal background;
• reduces the symptoms of menopause;

How many times to take per day

Doctors advise taking folic acid (vitamin B9) like all other vitamins according to the scheme: 1 time per day, preferably in the morning, with meals. Drink a small amount of water.

Daily allowance for pregnancy planning

Pregnant doctors necessarily attribute folates. Normally, a woman should receive 400-600 micrograms of acid per day, this is half a 1 mg tablet.

Daily allowance for pregnant women

How many weeks to take folic acid?

Due to the fact that folates do not accumulate in the body, acid is needed already in the first weeks of pregnancy, doctors recommend taking it even at the planning stage of the baby.

IMPORTANT!A woman's body needs vitamin B9 the most in the first 12 weeks of pregnancy.

Daily allowance for breastfeeding mothers

When breastfeeding, a young mother should drink this medicine with a dosage of at least 500-800 micrograms of "folk" per day. It is better to take it as part of dietary supplements or multivitamins, since not only the mother's body, but also the baby needs nutrients at this moment.

Daily Value for Men

If the male body receives at least 700 micrograms of folic acid daily, then the risk of spermatozoa with different types of abnormalities in the chromosomes is reduced by 25-30%.

To avoid infertility in men, B9 is advised to be taken in conjunction with vitamin E.

When a couple is planning a pregnancy, a man needs to drink folic acid 2-3 months in advance.

Conclusion

1. Vitamin B9 ( in other words folic acid) participates in the formation of the circulatory system and immunity.
2. Folic acid is essential women who decided get pregnant, as it participates in the normalization of the process of formation and development of the fetus.
3. folic acid for men necessary for the good functioning of the digestive tract, improving memory, as well as increasing fertility.
4. Folic acid is prescribed children to improve appetite, brain function and boost immunity.

In contact with

Folic acid - folacin, water-soluble folate, vitamin B9. In the body, it is converted into tetrahydrofolic acid, which is necessary for the maturation of megaloblasts and their transformation into normoblasts. With its deficiency, a megaloblastic type of hematopoiesis develops. It occupies an important place in the metabolism of purines and pyrimidines, the synthesis of nucleic acids, the metabolism of amino acids (glycine, methionine and histidine). After ingestion, folic acid, combining in the stomach with the internal factor of Castle (a specific glycoprotein), is absorbed in the upper part of the duodenum. Almost completely bound to plasma proteins. It undergoes activation in the liver under the influence of the enzyme dihydrofolate reductase, turning into tetrahydrofolic acid. Cmax in the blood is reached in 30-60 minutes. It is excreted by the kidneys both unchanged and as metabolites.

Indications:

Megaloblastic anemia, sprue, drug and radiation anemia and leukopenia, post-resection anemia, chronic gastroenteritis, intestinal tuberculosis, folic acid deficiency.
Prevention of folic acid deficiency in the body (including during pregnancy and lactation).

For therapeutic purposes, adults - 5 mg / day; children - in smaller doses depending on age. The course of treatment is 20-30 days.
For the prevention of folic acid deficiency in the body, it is used in doses of 20-50 mcg / day.

The daily requirement for folic acid is for children 1-6 months - 25 mcg, 6-12 months - 35 mcg, 1-3 years - 50 mcg, 4-6 years - 75 mcg, 7-10 years - 100 mcg, 11- 14 years - 150 mcg, 15 years and older - 200 mcg.
During pregnancy - 400 mcg / day, during lactation - 300 mcg / day.

Compound

Magnesium stearate E470, folic acid, amorphous silicon dioxide E551, talc.

Contraindications

Hypersensitivity to folic acid.
Folic acid can be used during pregnancy and lactation at the recommended doses.

Storage conditions: in a dry, dark place, at a temperature not exceeding 25 ° C

Information about the technical characteristics, scope of delivery, country of manufacture and appearance of the product is for reference only and is based on the latest available information from the manufacturer

Compound

pharmachologic effect

Indications for use

Mode of application

Interaction

Side effect

Contraindications

Use during pregnancy and lactation
Folic acid can be used during pregnancy and lactation at the recommended doses.

Overdose

special instructions