Medicines similar in action to nicotinic acid. Instructions for use and all the details about nicotinic acid

Producer: LLC "Pharmaceutical company" Zdorovye "Ukraine

ATC code: A11H A

Farm group:

Release form: Liquid dosage forms. Injection.

General characteristics. Compound:

Pharmacological properties:

Indications for use:

Important! Get to know the treatment

Dosage and administration:

Application Features:

Side effects:

Interaction with other drugs:

Storage conditions:

To store in the place protected from light at a temperature from 8 °C to 25 °C. Keep out of the reach of children.
Shelf life - 5 years

Leave conditions:

On prescription

Package:

Solution for injection 1%, 1 ml in ampoules No. 10 in a folding blister with a latch in a box, No. 10 in a box.

APPROVED
Order of the Chairman of the Committee
control of medical and
pharmaceutical activities
Ministry of Health and
social development
Republic of Kazakhstan
from "____" ____________ 201__
№ ____________________

Instructions for medical use
medicinal product

A nicotinic acid

Tradename
A nicotinic acid

International non-proprietary name
A nicotinic acid

Dosage form
Solution for injection 1%, 1 ml

Compound
1 ml of solution contains
active substance - nicotinic acid 10 mg,
Excipients: sodium bicarbonate, water for injection.

Description
Clear, colorless liquid.

Pharmacotherapeutic group
lipid-lowering drugs. Hypocholesterolemic and hypotriglyceridemic drugs. Nicotinic acid and its derivatives . A nicotinic acid.
ATX code C10AD02

pharmachologic effect
Pharmacokinetics
Nicotinic acid is rapidly absorbed when administered parenterally. It is evenly distributed over organs and tissues. It is inactivated mainly by methylation and less by conjugation. Partially biotransformed in the liver with the formation of N-methylnicotinamide, methylpyridonecarboxamides, glucuronide and a complex with glycine. The half-life (T 1/2) is 45 minutes. Excreted from the body by the kidneys in unchanged form and in the form of metabolites. Renal clearance depends on the concentration of nicotinic acid in plasma and may decrease at high plasma concentrations.

Pharmacodynamics
The structure of nicotinic acid is close to nicotinamide.
Nicotinic acid and its amide play an essential role in the life of the body: they are prosthetic groups of enzymes - codehydrase I (diphosphopyridine nucleotide - NAD) and codehydrase II (triphosphopyridine nucleotide - NADP), which are hydrogen carriers and carry out redox processes. Codehydrase II is also involved in the transfer of phosphate.
Nicotinic acid compensates for the deficiency of vitamin PP, has a vasodilating effect. Participates in the regulation of tissue respiration, fat metabolism, lowers total cholesterol, low-density lipoproteins (especially triglycerides).

Indications for use
- prevention and treatment of pellagra (avitaminosis RR)
As part of complex therapy: spasm of the vessels of the extremities (obliterating endarteritis, Raynaud's disease), neuritis of the facial nerve, ischemic disorders of cerebral circulation

Dosage and administration
Nicotinic acid is administered to adults subcutaneously, intramuscularly or intravenously slowly.
For intravenous jet administration a single dose of the drug is diluted in 10 ml of 0.9% sodium chloride solution, injected at least 5 minutes before (no faster than 2 mg of nicotinic acid per 1 minute).
For intravenous drip a single dose of the drug is diluted in 100-200 ml of 0.9% sodium chloride solution, the rate of administration is 30-40 drops per minute.
Subcutaneous and intramuscular injections are painful.
With pellagra, a 1% solution of 1 ml is administered intravenously or intramuscularly 1-2 times a day for 10-15 days.
In case of ischemic cerebrovascular accident, 1 ml of a 1% solution is administered intravenously (slowly).
For other indications appoint subcutaneously or intramuscularly at 10 mg (1 ml) 1 time per day for 10-15 days. It is possible to add to the infusion solution: 10 mg (1 ml) of nicotinic acid per 100-200 ml of the infusion solution.
Higher doses with intravenous administration: single - 100 mg (10 ml), daily - 300 mg (30 ml).

Side effects
- flushing of the face and upper half of the body with a feeling
tingling and burning (in persons with hypersensitivity)
- urticaria, skin rash, itching
- dizziness, feeling of a rush of blood to the head, headache
- orthostatic hypotension, collapse (with rapid intravenous administration)
With prolonged use of high doses
- dry skin, exfoliative dermatitis
- anorexia, vomiting, diarrhea
- violation of liver function, incl. fatty degeneration of the liver, jaundice
- arrhythmias
- paresthesia
- hyperuricemia
- hyperpigmentation, hyperkeratosis
- decreased glucose tolerance
- hyperglycemia
- transient increase in aspartate aminotransferase activity,
lactate dehydrogenase, alkaline phosphatase
- irritation of the mucous membrane of the gastrointestinal tract.
- asthenia
- pain at the site of subcutaneous and intramuscular injections.

Contraindications
- hypersensitivity to nicotinic acid
- severe forms of arterial hypertension
- atherosclerosis (for intravenous injections)
- peptic ulcer of the stomach and duodenum (in the stage
exacerbations)
- severe liver dysfunction: hepatitis, cirrhosis of the liver
- recent myocardial infarction
- decompensated diabetes mellitus
- gout and hyperuricemia
- pregnancy, lactation
- children's age up to 18 years

Drug Interactions
Oral contraceptives and isoniazid reduce the conversion of tryptophan to nicotinic acid and thus may increase the need for nicotinic acid.
Nicotinic acid reduces efficacy and toxicity barbiturates, anti-tuberculosis drugs, sulfonamides. When used together with sulfonylurea drugs, it can increase blood glucose levels. Also, nicotinic acid reduces the toxicity of neomycin and prevents the decrease in the concentration of cholesterol and high density lipoproteins induced by it.
Antibiotics may increase the redness of the skin caused by nicotinic acid.
Acetylsalicylic acid reduces the effect of reddening of the skin that occurs under the action of nicotinic acid.
Ciprofibrate it is not recommended to combine with nicotinic acid.
lovastatin, pravastatin due to the increased risk of adverse reactions, it is not recommended to combine with nicotinic acid.
Care must be taken when combined with antihypertensive drugs(may increase hypotensive effect), anticoagulants, acetylsalicylic acid(due to the risk of developing hemorrhages).
The drug potentiates the action fibrinolytic agents, antispasmodics and cardiac glycosides, the toxic effect of alcohol on the liver.
Do not mix with thiamine chloride solution (destruction of thiamine occurs).

special instructions
Before using the drug, you should consult with your doctor.
Since long-term use can lead to fatty degeneration of the liver, for the prevention of the latter, methionine-rich foods are included in the diet of patients or methionine, lipoic acid are prescribed. During treatment, it is necessary to monitor liver function. With the appearance of hypersensitivity to the drug (with the exception of cases of use as a vasodilator), it can be replaced with nicotinamide.
Carefully the drug is used for hyperacid gastritis, peptic ulcer of the stomach and duodenum (outside the stage of exacerbation).
The use of the drug may lead to an increase in the need for insulin in patients with diabetes mellitus. It is inappropriate to use for the correction of dyslipidemia in patients with diabetes mellitus.
It is necessary to regularly monitor glucose due to a possible decrease in glucose tolerance, as well as the level of uric acid in serum due to a possible increase as a result of long-term therapy.
Carefully prescribed for glaucoma, bleeding, arterial hypotension, impaired liver and kidney function, liver disease and a history of impaired function, diabetes mellitus, heart rhythm disturbances, migraine, alcohol abuse.
Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Given the side effects of the drug, care should be taken when driving vehicles and moving mechanisms.

Overdose
Symptoms: increased side effects from the cardiovascular system - arterial hypotension, headache, possible loss of consciousness, dizziness, feeling of a rush of blood to the head.
Treatment: drug withdrawal, detoxification therapy, symptomatic treatment. There is no specific antidote.

Release form and packaging
1.0 ml of the drug in neutral glass ampoules or sterile ampoules for syringe filling.
Each ampoule is labeled with label paper or writing paper, or the text is applied directly to the ampoule with gravure printing ink for glass products.
5 or 10 ampoules are packed in a blister pack made of PVC film and aluminum foil.
10 ampoules are placed in a box made of box cardboard or chrome-ersatz with a corrugated liner. An ampoule scarifier is put into each box. The box is pasted over with a label-package made of label paper or writing paper.
An ampoule scarifier is included in each package.
When packing ampoules with notches, rings and dots, scarifiers are not included.
Ampoule boxes or blister packs are placed in cardboard boxes.
The approved instructions for medical use in the state and Russian languages ​​are included in the group package with boxes or blister packs. The number of instructions is nested according to the number of boxes or packages.

Storage conditions
Store in a place protected from light, at a temperature not exceeding 30 ° C.
Keep out of the reach of children!

Shelf life
5 years
Do not use after the expiration date.

Terms of dispensing from pharmacies
On prescription

Manufacturer

Registration certificate holder
Chimpharm JSC, Republic of Kazakhstan
Address of the organization accepting claims from consumers on the quality of products (goods) on the territory of the Republic of Kazakhstan
Chimpharm JSC, Republic of Kazakhstan
Shymkent, st. Rashidova, 81
Phone number 7252 (561342)
Fax number 7252 (561342)
E-mail address [email protected]

Pharmachologic effect:
The structure of nicotinic acid is close to nicotinamide.
Nicotinic acid and nicotinamide are found in animal organs (liver, kidneys, muscles, etc.), in milk, fish, yeast, vegetables, fruits, buckwheat and other products. Nicotinic acid and its amide play an essential role in the life of the body: they are prosthetic groups of enzymes - codehydrase I (diphosphopyridine nucleotide - NAD) and codehydrase II (triphosphopyridine nucleotide - NADP), which are hydrogen carriers and carry out redox processes. Codehydrase II is also involved in the transfer of phosphate. Insufficiency of vitamin PP in humans leads to the development of pellagra (a disease caused by deficiency of nicotinic acid / vitamin PP /, tryptophan and riboflavin / vitamin B2 /).

Nicotinic acid method of administration and dosage:
Apply nicotinic acid inside (after eating) and parenterally (bypassing the gastrointestinal tract). For prophylactic purposes, adults are prescribed inside 0.015-0.025 g; children - 0.005-0.02 g every day.
With pellagra, adults are given inside 0.1 g 2-3-4 times every day for 15-20 days; parenterally injected 1% solution of 1 ml 1-2 times every day for 10-15 days. Children are prescribed inside from 0.005 to 0.05 g 2-3 times every day.
In other diseases, nicotinic acid is prescribed for adults at 0.02-0.05 g (up to 0.1 g); children - 0.005-0.03 g 2-3 times every day.
As a vasodilator in ischemic stroke (insufficient supply of oxygen to the brain tissue due to acute cerebrovascular accident), 1 ml of a 1% solution is administered intravenously.
Intravenously administered slowly. Subcutaneous and intramuscular injections of nicotinic acid are painful. Sodium nicotinate (nicotinic acid sodium salt) or nicotinamide can be used to avoid irritation.
Higher doses for adults inside: single - 0.1 g, daily - 0.5 g; in a vein (in the form of sodium salt): single - 0.1 g, daily -0.3 g. When taken orally, a single dose can be gradually increased (in the absence of side effects) to 0.5-1 g, and the daily dose - up to 3-5 g (mainly in the treatment of atherosclerosis and other disorders of lipid metabolism).
The daily requirement for nicotinic acid (and nicotinamide) is within 20 mg for an adult, within 25 mg for heavy physical labor, for babies from 6 months. up to 1 year - 6 mg, from 1 year to 1.5 years - 9 mg, from 1.5 to 2 years - 10 mg, from 3 to 4 years - 12 mg, from 5 to 6 years - 13 mg, from 7 up to 10 years old - 15 mg, from 11 to 13 years old - 19 mg, for boys 14-17 years old - 21 mg, for girls 14-17 years old - 18 mg.

Nicotinic acid contraindications:
Intravenous injections are contraindicated in severe forms of hypertension (persistent increase in blood pressure) and atherosclerosis.
Persons with increased susceptibility to nicotinic acid should be prescribed nicotinamide, except in cases where nicotinic acid is used as a vasodilator.
It should be borne in mind that long-term use of large doses of nicotinic acid can lead to the development of fatty degeneration of the liver. To prevent this complication, it is recommended to include in the diet foods rich in methionine - an essential / non-synthesized in the body / amino acids, or to prescribe methionine and other lipotropic (selectively interacting with fats) agents.

Nicotinic acid side effects:
Nicotinic acid (especially when taken orally on an empty stomach and in individuals with increased susceptibility) can cause redness of the face and upper half of the body, dizziness, a feeling of a rush of blood to the head, nettle rash, paresthesia (feeling of numbness in the limbs). These events go away on their own. With the rapid intravenous administration of a solution of nicotinic acid, a strong decrease in blood pressure can occur.

Release form:
Powder; tablets of 0.05 g (for medicinal purposes); 1.7% sodium nicotinate solution (corresponds to 0.1% nicotinic acid solution) in 1 ml ampoules; pH of solution for injection 5.0-7.0.

Synonyms:
Vitamin PP, Vitamin B, Apelagrin, Induracin, Liplit, Niacin, Nicolai, Nicodon, Niconacid, Nicoten, Nikovit, Pellagramin, Pelonin, Peviton, Vitaplex N.

Storage conditions:
List B. Powder - in a well-closed container, protected from light; tablets and ampoules - in a place protected from light.

Nicotinic acid composition:
Pyridinecarboxylic-3 acid.
White crystalline powder. Poorly soluble in cold water (1:70), better in hot water (1:15), hardly soluble in alcohol.

Additionally:
Nicotinic acid is part of the products withiodurol, vicein, xanthinol nicotinate, lipostabil, nikoverin, nikospan, spasmocor, etc.

Attention!
Before using the medication "A nicotinic acid" you need to consult a doctor.
The instructions are provided solely for familiarization with " A nicotinic acid».

Nicotinic acid belongs to the components of the vitamin complex of group B. This substance is also called vitamin PP. Nicotinic acid is very necessary for our body, as it takes part in many metabolic processes.

pharmachologic effect

Without nicotinic acid, the human body will not be able to function fully. It affects the educational and metabolic processes:

• dilates blood vessels;
• improves liver function;
• stimulates the digestive tract;
• restores the hematopoietic system in the bone marrow;
• promotes healing of ulcers and wounds;
• removes toxins from the body;
• improves the functioning of the cardiovascular system;
• lowers blood sugar levels.

This vitamin is simply indispensable in cosmetology, because it helps to cope with skin problems. It also improves the condition of hair and nails. With regular consumption of vitamin PP, lipid metabolism in the body improves. In addition, in patients with atherosclerosis, the level of cholesterol in the blood decreases.

Indications for use

Doctors prescribe nicotinic acid for pellagra. After the first course of treatment, patients' condition improves significantly. In addition, it is possible to cure not only the underlying disease, but also get rid of diseases of the gastrointestinal tract, the central nervous system. In patients, after treatment with nicotinic acid, the skin is cleared. After three weeks of treatment, disorders in the stomach and intestines also disappear. After a month of treatment, a person has pellagric psychoses.

Vitamin PP is useful for those who want to lose weight. After all, this vitamin normalizes metabolism and removes toxins and toxins from the body.

Instructions for use

In order for nicotinic acid to benefit the body, it must be taken in the right dosages. Nicotinic acid is available in the form of dragees and tablets, as well as in the form of injections. Nicotinic acid injections can be given subcutaneously, intramuscularly, and intravenously. However, injections with vitamin PP are very painful, so doctors prescribe them extremely rarely.

Dosage of the drug

The dosage of vitamins is prescribed based on the disease. As a rule, nicotinic acid should be taken three times a day, 0.1 g at a time. Vitamin is taken after meals and washed down with water. For prevention, nicotinic acid is prescribed in a lower dosage - 0.020 g at a time, three times a day.

Injections with vitamin PP should be done slowly. It is allowed to administer no more than 0.1 g intramuscularly and 0.01 g intravenously at a time. The course of treatment with this vitamin depends on the disease and its severity. On average, this treatment can last from three to five weeks. After that, you need to take a two-week break and, if necessary, the course of treatment can be repeated. Doctors do not advise to exceed the dosage of the drug. You can take no more than 5 g of the drug per day. If the drug is in injections, then its daily dose should not exceed 0.3 g.

Hair Benefits

Many cosmetologists use nicotinic acid for hair care. Also, this vitamin is prescribed for many diseases of the scalp and hair. The thing is that nicotinic acid dilates blood vessels. After vitamin PP is rubbed into the hair roots, it is absorbed into the skin and delivered through the blood vessels to the cells of the scalp, enriching them and the hair follicles with useful substances.

Some trichologists recommend rubbing nicotinic acid from ampoules into the scalp. It helps to stop hair loss and speed up hair growth. Nicotinic acid also helps to get rid of dandruff and hair problems. For the course of treatment, you will need 30 ampoules of the vitamin. One ampoule for one use. After opening, the drug should be applied very quickly to the roots of clean hair and rubbed in. Vitamin PP very quickly loses its beneficial properties in the air, so you should not leave the ampoules open. During the period of use of the drug, you need to stop using various shampoos and masks with silicone. It is best to apply the drug to slightly damp hair.

To make it more convenient to distribute the vitamin over the head, you can divide the hair into partings. You can apply the vitamin with your finger or a syringe. Even if you have thick hair, one ampoule will be enough. After all, the vitamin penetrates well into the blood vessels, and through them into the blood. Due to this, nicotinic acid is evenly distributed over all surfaces of the head.

Some people experience redness and burning of the scalp after applying the drug. This phenomenon is normal. If redness and burning do not go away, but intensify, severe urticaria, headache or itching appear, then you should stop using nicotinic acid. Most likely, these symptoms indicate individual intolerance to the drug.

Nicotinic acid does not pollute the hair, so it does not need to be washed off. The course of treatment should be a month. Every day the drug should be applied to the hair. Then a monthly break is made and, if necessary, the course of treatment is resumed. After such treatment, not only hair loss stops and problems with the scalp disappear, but hair growth also increases.

Skin Benefits

Nicotinic acid is involved in oxygen metabolism in skin cells. It dilates blood vessels and improves blood circulation, making the skin look healthy and supple. Nicotinic acid helps to remove excess fluid from the body, so it is prescribed for swelling of the body. Almost all decongestant cosmetics contain vitamin PP.

Nicotinic acid is involved in protein metabolism, as well as in the formation of elastin and collagen, which makes the skin supple, well-groomed and smooth. In addition, this vitamin is very important for women, as it affects the formation of sex hormones. Thanks to this body, women do not have wrinkles when there is an excess of hormones in her body.

Cosmetologists and doctors recommend using cosmetics with vitamin PP in sunny weather. Preparations containing this substance reduce the risk of developing melanoma and reduce the negative effects of ultraviolet rays on the skin.

Nicotinic acid is very useful for body wraps. It helps to get rid of cellulite. To make an anti-cellulite wrap, you need to take one ampoule of nicotinic acid and dissolve it in water in a ratio of 1:3. After that, you need to moisten a wide bandage in this liquid and wrap it around problem areas. A cling film and a warm blanket are applied on top. The skin should warm up well.

Side effects

From nicotinic acid, the following side effects may occur: dizziness, nausea, burning, nausea, diarrhea, a sharp decrease in blood pressure and an increase in the secretion of gastric juice.

If side effects begin to appear, then you should immediately stop using the drug and inform your doctor about it. Perhaps the doctor will reduce the dosage of nicotinic acid or cancel the drug.

Contraindications

Nicotinic acid should not be used for:

• violation of the kidneys;
• tendency to bleed;
• gout, glaucoma, or low blood pressure;
• exacerbation of diseases of the gastrointestinal tract, especially with ulcers;
• inflammation of the large intestine.

The drug nicotinic acid refers to vitamin derivatives of pharmacological production. This drug has a number of actions on the human body.

This allows you to effectively use it in many diseases.

Among the positive effects of nicotinic acid on the human body, the following should be noted:

• metabolic action leads to the normalization of metabolic processes, the restoration of the neural structure;
• as vitamin nicotinic acid and instructions for use contain this information, is responsible for lipid and carbohydrate metabolism in the human body;
• also, injections and tablets of nicotinic acid are able to restore impaired blood supply to certain parts of the body and human brain;
• vasodilation, which occurs under the influence of nicotinic acid, leads to the normalization of oxygen metabolism and oxidative processes;
• also nicotinic acid is able to have a detoxifying effect, so it can be used for poisoning and alcohol consumption.

These are not all the positive properties of nicotinic acid. The instructions for use that we offer you will help you deal with all the therapeutic effects. We hope to help you evaluate and use this drug.

Nicotinic acid indications and use

The drug nicotinic acid indications for use is quite extensive. This drug can be taken both for medicinal purposes and for the prevention of many diseases.

In particular, nicotinic acid is used for medicinal purposes in such diseases and conditions:

• osteochondrosis of the spinal column of various departments;
• ischemic stroke;
• violation of cerebral circulation;
• noise in ears;
• atherosclerosis;
• pellagra;
• impaired glucose tolerance;
• circulatory disorders in the lower extremities;
• haemorrhoids;
• lipid metabolism disorders and obesity;
• liver disease;
• alcohol intoxication;
• drug intoxication;
• professional intoxications;
• trophic ulcers of the lower extremities;
• decrease in visual acuity.

For prevention, nicotinic acid is used in:

• reduced risk of developing cancer;
• rapid breakdown of fats and a decrease in the level of intake of fatty acids in the human body;
• with gastritis with low acidity;
• to eliminate the symptoms of hemorrhoids;
• to improve memory and vision;
• to accelerate the process of splitting fats during weight loss.

The use of nicotinic acid requires careful monitoring by the attending physician. Self-treatment with nicotinic acid is not allowed due to the fact that negative consequences may develop in the human body. Like any other vitamin preparation, when overdosed, it causes irreparable damage to your health.

Vitamin nicotinic acid finds non-standard application

Very often, vitamin nicotinic acid finds non-standard use. In particular, this drug is very often used to rejuvenate and renew the skin of the face and body in many beauty salons. In fact, this is a completely justified method only if the treatment is carried out under the supervision of an experienced doctor.

Nicotinic acid indications in this case are very different. However, the principle of influence is quite simple.

This drug has a unique ability:

• on the one hand, expand the vessels of the peripheral circulatory system;
• on the other hand, it increases the supply of oxygen to tissues;
• on the third hand, it increases the outflow and removal of free radicals and aggressive toxins from skin cells.

Together, this has a rejuvenating effect on the human body. This is best seen on the skin. The skin becomes smooth, moisturized and gets a pleasant pink tint.

The drug nicotinic acid dosage

Lack of vitamin PP 2 tablets 3 times a day Children with a lack of vitamin PP ½ tablet 3 times a day Ischemic stroke 1-2 tablets 4 times a day or 2 ml intravenously Osteochondrosis of the cervical or thoracic spine 1 ml intramuscularly 1 time per day To improve blood circulation 1 tablet 3 times a day for 30 days

Nicotinic acid in ampoules

Nicotinic acid injections help to quickly introduce the drug into the human body and ensure its uniform distribution. Nicotinic acid in injections helps to avoid such negative side effects as an irritant effect on the gastric mucosa. Nicotinic acid in ampoules is prescribed for:

• increased acidity of gastric juice;
• in acute disorders of cerebral circulation of an ischemic nature;
• with pain syndromes in the trigeminal nerve and spine;
• with acute attacks of hemorrhoids.

Nicotinic acid is available in ampoules of 1 ml of a 1% solution. Usually prescribed 1 ampoule subcutaneously, intramuscularly or intravenously once or twice a day.

How to properly inject nicotinic acid

Nicotinic acid injections can be given in three ways:

• intramuscularly, 1 ml of a 1% solution;
• intradermally when compensating for vitamin deficiency;
• intravenously, 1-5 ml of a 1% solution diluted in 5 milliliters of saline.

Intramuscular and intradermal injections of nicotinic acid are quite painful. There is a burning sensation. After an intravenous injection of nicotinic acid, fever and redness of the skin may be felt. This is a normal physiological reaction of the body. If redness is not observed, then this may indicate that a person has certain problems with blood circulation.

Nicotinic acid tablets

Nicotinic acid preparations in tablets can be used for prevention and for the long-term treatment of certain diseases. In particular, nicotinic acid tablets are recommended to be used twice a year, in spring and autumn, for 1 month, for people who suffer from circulatory problems in the lower extremities. Thrombophlebitis and venous insufficiency is a direct indication for the use of nicotinic acid in tablets for a long time.

The drug nicotinic acid in tablets is used depending on the weight of the person and the severity of the disease, 1-2 tablets 3 times a day. It is advisable at this time to introduce cottage cheese and other foods rich in methionine into your diet. This will help protect the liver cells. With increased acidity of gastric juice, nicotinic acid tablets should be taken after meals and washed down with plenty of mineral water or warm milk.

The drug nicotinic acid contraindications

Vitamin nicotinic acid has minor contraindications. Usually this drug is not recommended for use in:

• individual intolerance to vitamin PP;
• with acute liver diseases;
• with liver failure;
• with exacerbation of gastric ulcer;
• with high blood pressure.

Also, nicotinic acid may have contraindications in a number of individual cases. Only a doctor can determine the appropriateness of using nicotinic acid in one form or another.

Electrophoresis with nicotinic acid in osteochondrosis

The appointment of electrophoresis with nicotinic acid in osteochondrosis helps to quickly remove accumulations of lactic acid from the tissues affected by the inflammatory process. This reduces swelling and eliminates pain. Also, electrophoresis with nicotinic acid is able to provide faster entry of other drugs into the affected area. This becomes possible due to the fact that blood flow increases, and the tissues are better supplied with oxygen and nutrients. Accordingly, the healing process is much faster.

Most often, electrophoresis with nicotinic acid is prescribed 1 time per day for ten days.

Effective treatment with nicotinic acid

To obtain the maximum effect, treatment with nicotinic acid should be started only after a complete examination of the state of health. The maximum effect is achieved only if a certain condition is associated with a lack of this vitamin in the human body.

The second principle is persistence. Treatment with nicotinic acid should be carried out in the form of courses. A single dose does not help. Only a constant intake according to the scheme prescribed by the doctor can give you a lasting therapeutic effect.

The action of nicotinic acid in intoxication

Scientists and practitioners have long noticed the positive effect of nicotinic acid in various intoxications. Nicotinic acid instructions for use take this into account, helps to quickly remove toxic substances from the human body. It binds free radicals and neutralizes the effects of toxic substances on target organ cells.

Nicotinic acid is widely used in this capacity in the removal of a hangover syndrome, in the treatment of alcoholism and drug addiction, and in occupational harmful effects.

The drug nicotinic acid: the price is affordable for everyone

Nicotinic acid has an amazing benefit. This drug at its cost is available to almost everyone. For nicotinic acid, the price is currently around 20 rubles for 1 pack of injections or tablets. The course of treatment requires no more than 3 packs. So consider how nicotinic acid and the price correspond to their useful qualities. Use affordable drugs and be healthy.

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Indications for the appointment of nicotinic acid

Nicotinic acid, known as vitamin PP, belongs to the B group of vitamins and is found in many foods, both plant and animal in origin. Most of all it is found in bread products, buckwheat, yeast, liver, meat products, fish, fruits, vegetables. Nicotinic acid is amidated in the body. Nicotinamide has the same vitamin activity as nicotinic acid.

Indications for the use of nicotinic acid

The presence of nicotinic acid improves liver function, stimulates the hematopoietic activity of the bone marrow, enhances the secretion of the gastric mucosa, activates the trophic effect, accelerating the healing of ulcers and wounds, facilitates detoxification processes and relieves spastic conditions of blood vessels in the body.

Nicotinic acid has a positive effect on lowering cholesterol levels in the blood, has a beneficial effect on other disorders in lipoprotein metabolism, which are observed in atherosclerosis.

Nicotinic acid is prescribed as a specific agent against pellagra. When using nicotinic acid in this disease, it is possible to achieve a rapid therapeutic effect, noted both in relation to skin and gastrointestinal manifestations, and in relation to the central nervous system. After 2–3 weeks, skin dermatitis and dyspepsia disappear almost completely, and after 1–2 months, pelagic psychoses also become a thing of the past.

The therapeutic use of nicotinic acid is not only for its anti-pellagic properties; its positive effect is noted in the treatment of diseases of the liver, heart, gastrointestinal tract, with sluggish processes of healing ulcers and wounds. Nicotinic acid also has a vasodilating effect.

Nicotinic acid preparations are used as a vasodilator for endarteritis and other processes that are accompanied by vasospasm. Nicotinic acid is also used in the treatment of multiple sclerosis.

Nicotinic acid finds detoxifying use in the treatment of poisoning with drugs of the sulfanilamide group.

The drug has low toxicity and is well tolerated by patients.

Preparations containing nicotinic acid

• Nikoverin is available in the form of tablets containing 0.02 g of papaverine hydrochloride and 0.05 g of nicotinic acid. It is intended as a vasodilator for hypertension, migraines, angina pectoris and other diseases characterized by spasms.
• Nicotinamide, perceived better than nicotinic acid, is prescribed for the same indications, but there are no vascular reactions. Therefore, it is ineffective as a vasodilator.
• Paniverin, which is a preparation of papaverine salt with nicotinic acid, is available in tablets and ampoules. It is used for vascular spasms, cerebral atherosclerosis, sclerosis of the heart vessels, obliterating endarteritis.

A nicotinic acid

* These products are located on the website of the network of pharmacies "Thetis"

Pharmachologic effect:

The structure of nicotinic acid is close to nicotinamide.

Nicotinic acid and nicotinamide are found in animal organs (liver, kidneys, muscles, etc.), in milk, fish, yeast, vegetables, fruits, buckwheat and other products. Nicotinic acid and its amide play an essential role in the life of the body: they are prosthetic groups of enzymes - codehydrase I (diphosphopyridine nucleotide - NAD) and codehydrase II (triphosphopyridine nucleotide - NADP), which are hydrogen carriers and carry out redox processes. Codehydrase II is also involved in the transfer of phosphate. Insufficiency of vitamin PP in humans leads to the development of pellagra (a disease caused by deficiency of nicotinic acid / vitamin PP /, tryptophan and riboflavin / vitamin B2 /).

Indications for use:

Nicotinic acid and its amide are specific anti-pellagric agents (drugs for the treatment of pellagra), and therefore they are designated as vitamin PP. Their use, especially in the early stages of the disease, leads to the disappearance of pellagra phenomena.

Nicotinic acid has not only antipelagric properties; it improves carbohydrate metabolism, has a positive effect on mild forms of diabetes, diseases of the liver, heart, peptic ulcer of the stomach and duodenum and enterocolitis (inflammation of the small and large intestine), sluggishly healing wounds and ulcers. It also has a vasodilating effect.

Nicotinic acid has lipoproteinemic activity (reduces the level of lipoproteins in the blood). In large doses (3-4 g per day) lowers the content of triglycerides and beta-lipoproteins in the blood. In patients with hypercholesterolemia (with high blood cholesterol), under its influence, the ratio of cholesterol / phospholipids in low-density lipoproteins decreases.

Assign as a specific tool for the prevention and treatment of pellagra. In addition, they are used for gastrointestinal diseases (especially for gastritis / inflammation of the stomach / with low acidity), liver diseases (acute and chronic hepatitis, cirrhosis), spasms (sharp narrowing of the lumen) of the vessels of the extremities, kidneys, brain (see Nikoverin , Nikoshpan, Xanthinol nicotinate, 177), with neuritis of the facial nerve (inflammation of the facial nerve), atherosclerosis, long-term non-healing wounds and ulcers, infectious and other diseases.

Mode of application:

Apply nicotinic acid inside (after eating) and parenterally (bypassing the gastrointestinal tract). For prophylactic purposes, adults are prescribed inside 0.015-0.025 g; children - 0.005-0.02 g per day.

When pellagra is given to adults inside, 0.1 g 2-3-4 times a day for 15-20 days; parenterally injected 1% solution of 1 ml 1-2 times a day for 10-15 days. Children are prescribed inside from 0.005 to 0.05 g 2-3 times a day.

In other diseases, nicotinic acid is prescribed for adults at 0.02-0.05 g (up to 0.1 g); children - 0.005-0.03 g 2-3 times a day.

As a vasodilator in ischemic stroke (insufficient supply of oxygen to the brain tissue due to acute cerebrovascular accident), 1 ml of a 1% solution is administered intravenously.

Intravenously administered slowly. Subcutaneous and intramuscular injections of nicotinic acid are painful. Sodium nicotinate (nicotinic acid sodium salt) or nicotinamide can be used to avoid irritation.

Higher doses for adults inside: single - 0.1 g, daily - 0.5 g; in a vein (in the form of sodium salt): single - 0.1 g, daily -0.3 g. When taken orally, a single dose can be gradually increased (in the absence of side effects) up to 0.5-1 g, and the daily dose - up to 3-5 g (mainly in the treatment of atherosclerosis and other disorders of lipid metabolism).

The daily requirement for nicotinic acid (and nicotinamide) for an adult is about 20 mg, for heavy physical labor - about 25 mg, for children from 6 months. up to 1 year - 6 mg, from 1 year to 1.5 years - 9 mg, from 1.5 to 2 years - 10 mg, from 3 to 4 years - 12 mg, from 5 to 6 years - 13 mg, from 7 up to 10 years old - 15 mg, from 11 to 13 years old - 19 mg, for boys 14-17 years old - 21 mg, for girls 14-17 years old - 18 mg.

Side effects:

Nicotinic acid (especially when taken orally on an empty stomach and in people with hypersensitivity) can cause redness of the face and upper half of the body, dizziness, a feeling of a rush of blood to the head, nettle rash, paresthesia (feeling of numbness in the limbs). These events go away on their own. With the rapid intravenous administration of a solution of nicotinic acid, a strong decrease in blood pressure can occur.

Contraindications:

Intravenous injections are contraindicated in severe forms of hypertension (persistent increase in blood pressure) and atherosclerosis.

Persons with hypersensitivity to nicotinic acid should be prescribed nicotinamide, except in cases where nicotinic acid is used as a vasodilator.

It should be borne in mind that long-term use of large doses of nicotinic acid can lead to the development of fatty degeneration of the liver. To prevent this complication, it is recommended to include in the diet foods rich in methionine, an essential / non-synthesized in the body / amino acid, or to prescribe methionine and other lipotropic (selectively interacting with fats) agents.

Release form:

Powder; tablets of 0.05 g (for medicinal purposes); 1.7% sodium nicotinate solution (corresponds to 0.1% nicotinic acid solution) in 1 ml ampoules; pH of solution for injection 5.0-7.0.

Storage conditions:

List B. Powder - in a well-closed container, protected from light; tablets and ampoules - in a place protected from light.

Synonyms:

Vitamin PP, Vitamin B, Apelagrin, Induracin, Liplit, Niacin, Nicolai, Nicodon, Niconacid, Nicoten, Nikovit, Pellagramin, Pelonin, Peviton, Vitaplex N.

Pyridinecarboxylic-3 acid.

White crystalline powder. Poorly soluble in cold water (1:70), better in hot water (1:15), hardly soluble in alcohol.

pharmacological group.