Candide topical solution, topical solution. Contraindications for use

Candide active against molds, yeast-like fungi (Rhodoturola, Torulopsis, Candida) and dermatophytes (Microsporum, Epidermophyton, Trichophyton), the causative agent of erythrasma, lichen multi-colored, as well as Aspergillus, Malassezia furfur, gram-positive bacteria (Staphylococcus spp., Corynebacterium minutissimum, Streptococcus spp. ) and gram-negative (Gardnerella vaginalis, Bacteroides spp.), and Trichomonas vaginalis.
Absorption of clotrimazole with intravaginal administration ranges from 3 to 10% of the administered dose. For 48-72 hours, low concentrations of the drug in the blood and high in the vaginal secretion remain. Clotrimazole is metabolized to inactive metabolites in the liver.

Indications for use

Mode of application

Side effects

Contraindications

Pregnancy

Interaction with other drugs

Overdose

Release form

Storage conditions

Synonyms

Compound

candide cream 1%
1 g of cream contains 10 mg of clotrimazole.

Candide lotion 1%
1 ml of lotion contains 10 mg of clotrimazole

Additionally

main parameters

3D images

Compound

Description of the dosage form

Colorless, transparent, viscous liquid.

pharmachologic effect

Pharmacodynamics

Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent.

The antimycotic effect is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties and leads to cell lysis.

Dermatophytes, yeast-like fungi (genus Candida, Torulopsis glabrata, Rhodotorula), mold fungi, as well as the causative agent of multi-colored lichen Pityriasis versicolor and the causative agent of erythrasma.

It has an antimicrobial effect against gram-positive (staphylococci and streptococci) and gram-negative bacteria ( Bacteroides, Gardnerella vaginalis), as well as with regard to Trichomonas vaginalis.

Pharmacokinetics

When applied topically, the adsorption of clotrimazole from the mucous membranes is negligible.

Indications for Candide

Candidal stomatitis.

Contraindications

Hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The use of the drug during pregnancy or lactation is allowed in cases where the intended benefit to the mother outweighs the risk to the fetus or infant.

Side effects

The drug is usually well tolerated. In rare cases, with hypersensitivity to the components of the drug, allergic reactions are noted - redness of the oral mucosa, burning sensation and tingling at the site of application of the drug, urticaria.

If irritation occurs, the drug must be discontinued.

Interaction

With simultaneous use with amphotericin B, nystatin, the activity of clotrimazole may decrease.

Dosage and administration

locally, 10-20 drops (1/2-1 ml) are applied to the affected areas of the oral cavity with a cotton swab 3-4 times a day. Improvement usually occurs on the 3-5th day of treatment, however, treatment should be continued until the clinical manifestations of the disease are completely eliminated.

Overdose

Candide is a drug based on clotrimazole with fungistatic and fungicidal properties used to treat fungal infections. In small doses, it inhibits the development and reproduction of the pathogen, and in large doses it destroys the fungus, disrupting the synthesis of substances necessary for the structure of its cells.

Properties, composition and forms of release of the drug Candide

The active substance of the drug Candide is effective in the fight against many types of fungi that cause damage to the skin, nails and mucous membranes. Clotrimazole, when applied topically, penetrates the tissues and accumulates in them at a maximum concentration, practically not being absorbed into the blood. The drug is able to influence the production of ergosterol, which is necessary for the cell membranes of the pathogen. With a lack of this substance, the cell walls are destroyed, the fungus cannot multiply and dies.

Different dosage forms of the drug contain excipients that facilitate its use. Typically, for the treatment of fungus in children, Candide is used in the following forms:

• cream (ointment) Candide, 1% - a white substance in aluminum tubes of 20 g;
• solution (drops) for topical use, 1% - a viscous transparent liquid for treating the oral mucosa with thrush, a 15 ml dropper bottle;
• solution for external use, 1% - 20 ml polyethylene bottle;
• powder 10 mg / g - white powder for the treatment of fungus, plastic bottle 30 g.

There are other dosage forms of Candida: gel, vaginal tablets, etc. Based on the indications and concentration of the active substance, they are more suitable for the treatment of fungal infections in adults.

Indications for use

In pediatrics, including in newborns, Candide is used to treat oral candidiasis (thrush), stomatitis, skin candidiasis and other fungal infections (we recommend reading:). The drug is prescribed for children of any age with lesions of the skin, nails, hairline or mucous membranes caused by the activity of the fungal flora:

• oral candidiasis (thrush) - foci of white plaque on the oral mucosa;
• candidal stomatitis - inflammation of the mucous membrane caused by yeast, mold and other types of fungi, as well as a decrease in immunity;
• diaper dermatitis - the reproduction of a fungus on the skin due to insufficient hygiene of the baby or non-compliance with temperature conditions in the room;
• some types of lichen, mycoses of the skin or nails;
• other lesions of the skin or mucous membranes, provoked by uncontrolled reproduction of the fungal flora.

Instructions for use with dosages by age

There are no age restrictions for the Candide drug - according to indications, it is prescribed even for newborns and infants. However, it is necessary to strictly observe the dosage prescribed by the doctor or indicated in the instructions for a specific dosage form, and in no case should the drug be used independently, without the appointment of a specialist.

Solution for the treatment of stomatitis and thrush

Thrush and stomatitis, provoked by fungi, often develop in infants against the background of an immature immunity. Foci of white plaque appear in the oral cavity, when you try to remove it, the mucous membrane begins to bleed (for more details, see the article:). Taking a smear, the doctor will determine its origin and make a diagnosis. If left untreated at this stage, the mucous membrane becomes inflamed, stomatitis develops.

With candidal stomatitis, Candide for newborns is prescribed in the form of a solution for topical use in a plastic dropper bottle. Dose for children, incl. newborns, is 5-10 drops (0.25-0.5 ml) of the solution - it is applied to a cotton swab or a finger wrapped in gauze, after which the foci of white plaque in the oral cavity are lubricated 3-4 times a day.

It is impossible to stop treatment at the first signs of improvement in the condition, it is necessary to continue using the drug until the symptoms are completely eliminated.

If the baby is breastfed, the mother should not only treat the baby's mouth with a solution, but also her nipples to prevent re-infection.

Cream and solution for external use

With fungal lesions of the skin or nails, lichen, mycoses of unspecified origin, Candide is used in the form of a cream or ointment according to the following scheme:

• wash the affected area of ​​​​skin with soap with a neutral level of acidity;
• dry the skin thoroughly;
• apply a thin layer of cream and gently rub it into the tissues.

The procedure is performed 2-3 times a day after meals (feeding), the duration of the course of treatment depends on the specific diagnosis and age of the patient. In some cases, the doctor recommends continuing treatment for a few more days after the symptoms have completely disappeared.

In the presence of the same diseases, it is possible to use a 1% solution for external use. Children younger than 2-3 years old are often prescribed this particular dosage form, since the solution contains fewer excipients, which means less likelihood of adverse reactions. The solution is used according to the same scheme as the cream: applied to washed with soap and dried skin 2 or 3 times a day.

Powder for skin treatment

For the treatment of fungal infections localized on the skin of a child, Candide powder is used externally. Before applying the drug, the affected area must be washed and dried, then spray the powder from the bottle onto the site of the fungus localization. The procedure is carried out 2-3 times a day, the duration of treatment is usually about 14 days, but the doctor can change this period depending on the condition and age of the child. With a large affected area or in order to prevent re-infection, it is sometimes recommended to apply a little powder to the baby's clothes or diapers.

Contraindications and possible side effects

Candida in the treatment of children, as a rule, is well tolerated. The only absolute contraindication is individual sensitivity to clotrimazole or any of the excipients. Candide is not used on damaged areas of the skin (sores, scratches, etc.) and in the eye area.

Side effects can occur in the form of a local allergic reaction - itching, burning or redness of the skin or mucous membranes, sometimes nausea is observed. In this case, treatment with Candide is stopped.

When treating skin infections with this drug, occlusive dressings should not be used - the active substance penetrates into the blood and has a negative effect on the children's body. In particular, inhibition of the function of the adrenal cortex in children is observed.

Cost and analogues

Candide is available in pharmacies without a prescription. The average cost of different dosage forms:

As analogues of Candida, you can use any drug, the main component of which is clotrimazole. When choosing a similar medication, you need to carefully study the instructions and listen to the doctor's recommendations. The most popular analogues of Candida: Canison, Rederm, Candiderm, Candibene, Antifungol, etc.

Instructions for use:

Candide is a synthetic broad-spectrum antifungal drug used to treat fungal infections of the skin and mucous membranes.

pharmachologic effect

Candide, as an antifungal drug, is widely used to treat various candidal diseases, penetrating well into various skin layers and destroying bacterial cells.

The active substance is active against many yeast-like, mold and yeast fungi (Torulopsis, Candida, Rhodoturola), dermatophytes (Trichophyton, Epidermophyton, Microsporum), and some strains of gram-negative and gram-positive bacteria (Streptococcus spp., Staphylococcus spp., Corynebacterium minutissimum, Bacteroides spp. ., Gardnerella vaginalis).

Release form

The drug is produced in the form of a solution and cream for external use:

• 1% Candida solution - in the form of a viscous colorless transparent liquid. 1 ml contains 10 mg of the active substance clotrimazole. The excipient is propylene glycol. In polyethylene bottles of 20 ml;
• 1% homogeneous white cream Candide. 1 g of cream contains 10 mg of the active ingredient clotrimazole. Excipients - liquid paraffin, propylene glycol, emulsion wax, white petrolatum, methylparaben, alcohol, anhydrous sodium phosphate, propylparaben, sodium dihydrogen phosphate, butylhydroxytoluene and purified water. In aluminum tubes of 20 g.

Candide is also available in the form of vaginal tablets. Each tablet contains 500 mg of the active ingredient clotrimazole.

Indications for use Candida

Candide according to the instructions is used for:

• skin candidiasis;
• Candida vulvitis;
• Candida balanitis;
• Epidermophytosis;
• stomatitis;
• Candidal paronychia;
• Candidiasis of the external genitalia and anorectal region;
• Trichophytosis;
• Mycosis of nails;
• Dermatophyte of the face, body, legs;
• Interdigital fungal erosion;
• Multicolored lichen;
• Fungal diaper dermatitis;
• Erythrasma;
• Dermatomycosis;
• Microsporia.

Candide is also used according to the instructions for the rehabilitation of the birth canal before childbirth.

Contraindications

The drug is contraindicated in case of hypersensitivity to the active substance - clotrimazole. The use of Candide ointment during menstruation and in the first trimester of pregnancy is also contraindicated.

When prescribing the drug during breastfeeding, care must be taken.

Ointment and solution Candide should not be used on skin areas with violations of the integrity of the skin.

Instructions for use Candida

Candide ointment, as well as Candide solution, is applied in a small amount to the affected areas of the skin, previously washed and dried, and rubbed.

Treatment is quite long, it should be continued for another 2 to 4 weeks after the disappearance of symptoms to prevent relapse.

Candide solution is used on hairy areas of the skin and with a large affected area.

Candide in the form of vaginal tablets is prescribed at bedtime, 500 mg once. Also, one tablet of 500 mg is enough for the sanitation of the birth canal. The drug is administered intravaginally, deeply.

Side effects

Candide solution and cream rarely causes side effects in the form of local irritation, which usually disappears later on its own.

When using Candida in the form of vaginal tablets, itching, burning, swelling of the vaginal mucosa, vaginal discharge, frequent urination or headache may occur.

According to the instructions, Candide, when used simultaneously with nystatin, amphotericin B and natamycin, reduces its activity.

The safety of using Candida during pregnancy and lactation has not been studied. Therefore, it is not recommended to prescribe the drug in the first trimester of pregnancy, as well as in high doses, on large areas of the skin and to treat for a long time.

Storage conditions

Candide is allowed for over-the-counter dispensing. The shelf life of tablets and solution is 3 years, Candide cream is 2 years.

Content

In dermatology, gynecology and other areas, doctors use the drug Candide. It is highly effective, quickly achieving results, contains clotrimazole. Different forms of release of the drug are used for external and intravaginal use. Read the instructions for using Candida and consult your doctor before starting treatment.

Preparation Candide

Doctors often prescribe the drug Candide - instructions for its use contain information that the drug refers to antifungal agents for treating the oral cavity, genital organs and skin. The active substance of the composition is clotrimazole, which destroys the cells of bacteria and fungal pathogens, preventing them from multiplying, thereby leading to their death.

Composition and form of release

Five forms of Candida are produced, differing in purpose and composition. Detailed composition:

Pharmacodynamics and pharmacokinetics

The entire line of drugs belongs to antifungal agents with a wide spectrum of action for topical use. The active substance of the composition is clotrimazole, an imidazole derivative. Its antimycotic effect is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of the fungus. The component causes a change in the structure of tissues and leads to lysis (dissolution) of the fungal cell. At low concentrations it acts as a fungistatic, at high concentrations it acts as a fungicide.

In fungicidal concentrations, the drug interacts with mitochondrial enzymes that work like peroxidase, which increases the concentration of hydrogen peroxide to a toxic level. Candida yeast-like fungi, dermatophytes, Rhodotorula, Torulopsis glabrata, mold fungi, Pityriasis versicolor (versicolor) and erythrasma are sensitive to the active substance. The drug destroys gram-positive microorganisms, staphylococci, streptococci, gram-negative Bacteroides, Gardnerella vaginalis, Trichomonas vaginalis.

When applied topically, the absorption of clotrimazole is negligible, so the systemic effect is practically not manifested. When applied externally, the concentration of the active substance in the epidermis is higher than in the subcutaneous tissue and dermis. With intravaginal administration of the gel or tablets, the absorption of clotrimazole is up to 10% of the dose, the concentration lasts up to 72 hours. In the liver, the substance is metabolized to inactive metabolites.

Indications for use

According to the instructions for use, indications for use are different factors. The annotation contains:

• candidiasis stomatitis of the oral cavity;
• fungal infections of the skin;
• erosion between the fingers caused by fungi;
• mycoses with a complication of a secondary infection;
• multi-colored lichen;
• erythrasma;
• candidal vulvovaginitis, paronychia, balanitis, thrush;
• trichomoniasis;
• genital superinfections;
• dermatophytosis of the hairy areas of the head, face, body, legs;
• onychomycosis (nail fungus);
• candidiasis of the skin, anorectal region, external genital organs;
• fungal diaper dermatitis;
• dermatomycosis;
• sanitation before childbirth of the birth canal.

Method of application and dosage

For each drug of the Candide line, there is a separate instruction for use. So, cream (erroneously called ointment) and powder are used for external application to the skin. Gel and tablets (vaginal suppositories) are administered intravaginally, drops of the solution are used to treat the oral cavity. Depending on the severity of the disease, the course and dosage regimen will differ.

Cream Candide

According to the instructions, Candide cream or ointment is applied to pre-washed and dry affected skin areas up to 2-3 times / day. The product is lightly rubbed and left until absorbed. Treatment of candidiasis continues for 2-4 weeks after the disappearance of the clinical manifestations of the disease, to ensure mycological cure and prevent recurrence of the infection.

Powder

Powder Candide, according to the instructions, has an external application. It is applied to the affected areas of the skin 3-4 times / day. According to reviews, improvement occurs in 3-5 days, but a successful cure requires the systematic use of the drug. The average duration of antifungal therapy is a month, with pityriasis versicolor - 1-3 weeks, with erythrasma - 2-4 weeks. If interdigital fungal erosions of the legs are treated, then the duration of the powder application continues for another two weeks from the moment the symptoms stop.

Gel

For intravaginal use only, Candide gel is intended for the treatment of thrush. According to the instructions, a full applicator with gel (approximately 5 g) is collected and inserted into the vagina. It is advisable to administer the drug in the supine position with slightly bent knees. Treatment continues every evening for six days. The repetition of the course is determined by the doctor.

Solution

The instruction suggests using a Candide solution for the oral cavity in the amount of 10-20 drops (0.5-1 ml of the drug). The agent is applied to the affected areas of the skin 3-4 times / day with a cotton swab. On the 3rd-5th day, patients notice an improvement in their condition, but treatment should still be continued until the clinical manifestations of the disease are completely eliminated.

Candles

Candide tablets are mistakenly called candles. The drug is used intravaginally, injected as deep as possible in the supine position with legs slightly bent. Every evening you need to use one tablet for six days. For the rehabilitation of the birth canal before childbirth, one piece is assigned. An applicator is used to facilitate the administration of the drug. Instructions for its use (also suitable for using the gel):

• push the piston all the way;
• place a tablet inside;
• gently insert the applicator deep into the vagina;
• slowly press the piston to the stop;
• remove the applicator;
• remove the plunger completely, wash with warm soapy water and wipe dry.

special instructions

If Candide is used, the instructions for use require the study of special instructions. Some of the excerpts say that:

• the solution is used only as an oral treatment;
• intravaginal forms cannot be used during menstruation;
• to prevent reinfection, it is also desirable for the sexual partner to undergo a course of treatment;
• drugs are not used in ophthalmology;
• with trichomoniasis, for successful treatment, therapy is combined with the use of systemic drugs, for example, Metronidazole;
• with the simultaneous manifestation of candidiasis on the vulva of the labia and adjacent areas, it is allowed to combine the intravaginal forms of the drug with the cream;
• during pregnancy, the applicator cannot be used to administer the gel and tablets;
• in the treatment of Candida patients with liver failure should monitor the functional parameters of the liver;
• if signs of hypersensitivity or local irritation appear on the skin and genitals, therapy is canceled;
• if there is no effect from the drugs within a month, the diagnosis should be reconsidered;
• medicines do not affect the concentration of attention and the speed of psychomotor reactions, so they can be used when driving vehicles and dangerous mechanisms.

During pregnancy

During pregnancy and breastfeeding, the instruction allows the use of the drug only if the benefit to the mother exceeds the risk to the fetus or newborn. Intravaginal forms of drugs are contraindicated in the first trimester of pregnancy. According to experiments, high doses of clotrimazole cause embryotoxic effects. It is not known whether the active substance is excreted in breast milk.

Candide for children

There is no experience in the use of line drugs in children, therefore, before prescribing, it is worth considering the possible risk to the body. It is known that long-term use of clotrimazole in a child leads to an increased risk of adrenal suppression. Be sure to get your doctor's permission before using any dosage forms of the drug and do not try to prescribe them yourself.

drug interaction

According to the instructions, the simultaneous use of clotrimazole with amphotericin B, nystatin reduces the effect of the drug. Doctors are allowed to combine drugs with systemic antibiotics and antimicrobial agents, plus forms for external and intravaginal use. Before using any combination of drugs, you should consult your doctor.

Side effects

According to patients, the drugs are well tolerated. Possible side effects in their application are:

• allergic reactions, redness of the mucous membranes of the vagina;
• burning, tingling at the site of application;
• urticaria, erythema;
• itching, blistering;
• swelling, irritation of the vaginal mucosa, peeling;
• when such symptoms appear, Candide therapy is canceled.

Overdose

When applied topically, an overdose of Candide is unlikely and does not lead to situations that threaten human life and health. With prolonged use of the cream in children or with an occlusive dressing in adults, the risk of suppression of the function of the adrenal cortex increases, therefore, during treatment, the vital signs of these organs should be monitored.

Contraindications

Instructions for use Candide advises to use drugs with caution during pregnancy, lactation, and in childhood. Contraindications for intravaginal forms of drugs are the first trimester of pregnancy and with the use of an applicator, for all others - hypersensitivity to the components of the composition and other imidazole derivatives.

Terms of sale and storage

You can buy Candide without a prescription, it is stored away from light and children at a temperature of no more than 25 degrees. The expiration date is three years from the date of issue.

Analogues

There are many analogues of Candida in terms of the active ingredient clotrimazole. There are also indirect substitutes for the drug, acting similarly in terms of therapeutic effect. Analogues of the drug include medicines with clotrimazole in the composition:

• Clotrimazole;
• Canison;
• Candibene;
• Travocort;
• Biphon;
• Bifunal;
• Kanespor;
• Mycospor;
• Dermazol;
• Ketozoral.

Candida price

You can buy drugs of the line through the Internet or pharmacy chains. Prices for funds depend on the form of release and the concentration of clotrimazole. The approximate cost will be