Antigrippin 12 in powders Petersburg pharmacies instructions. Interaction with other drugs. Possible side effects

Taking the drug relieves a runny nose, relieves swelling of the nasal mucosa with rhinitis. Antigrippin contains paracetamol, ascorbic acid and chlorpheniramine maleate. These substances, combining their therapeutic properties, have an enhanced effect of the drug on the body.

On this page you will find all the information about AntiGrippin: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used AntiGrippin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The drug for the symptomatic treatment of acute respiratory diseases.

Terms of dispensing from pharmacies

Released without a doctor's prescription.

How much does AntiGrippin cost? The average price in pharmacies is at the level of 320 rubles.

Release form and composition

This drug is produced:

• in the form of oral, water-soluble powder Antigrippin in bags of 5 grams No. 10 in secondary packaging;
• in the form of tablets Antigrippin effervescent in plastic cases No. 10, blisters No. 10 or strips No. 2, No. 4, No. 6;
• in the form of tablets Antigrippin effervescent with grapefruit or raspberry flavor in plastic cases No. 10, blisters No. 10 or strips No. 2, No. 4, 36;
• in the form of effervescent tablets children's Antigrippin in plastic cases No. 10, blisters No. 10 or strips No. 2, No. 4, No. 6.

The composition depends on the form of release:

• 1 taste effervescent tablet contains paracetamol 500mg, ascorbic acid 200mg, chlorphenamine maleate 20mg. Additionally contains: sodium bicarbonate, citric acid, povidone, sodium carbonate, sorbitol, sodium lauryl sulfate, macrogol, sodium riboflavin-5-phosphate, as well as sodium saccharinate, raspberry flavor "Raspberry", flavor corrector and beetroot powder (for raspberry tablets) or flavor corrector, flavors lemon "Lemon" and grapefruit "Grapefruit" (for grapefruit tablets).
• 1 sachet of oral powder contains paracetamol 500mg, ascorbic acid 200mg, chlorphenamine maleate 20mg. The pharmaceutical composition of the powder additionally includes: sodium bicarbonate, citric acid, povidone, acesulfame potassium, sorbitol, sodium cyclamate, sucrose, aspartame, sodium docusate, as well as chamomile extract (for chamomile powder) or lime flavors "Lime", caramel and honey (for honey lemon powder).
• 1 effervescent tablet for children includes paracetamol 250mg, ascorbic acid 50mg, chlorphenamine maleate 3mg. Additionally contains: sodium bicarbonate, citric acid, sodium saccharinate, sorbitol, sodium carbonate, povidone, silicon dioxide, macrogol, and "Red Fruit" fruit flavor.
• 1 effervescent tablet contains paracetamol 500mg, ascorbic acid 200mg, chlorphenamine maleate 20mg. Additionally contains: sodium bicarbonate, citric acid, sodium saccharinate, sorbitol, sodium carbonate, povidone, sodium lauryl sulfate, macrogol, and "Lime" lime flavor.

Pharmacological effect

Antigrippin is a complex drug that surpasses many analogues due to the successful combination of several active ingredients:

1. Ascorbic acid (vitamin C) is a powerful antioxidant. It helps to restore the body's defenses, participates in the normalization of redox processes, reduces the permeability of small vessels and has a pronounced immunomodulatory effect.
2. Paracetamol is an antipyretic and analgesic and anti-inflammatory agent known to everyone since childhood. Today, according to experts from the World Health Organization, it is one of the safest of the group of nonsteroidal drugs with anti-inflammatory effect.
3. Chlorphenamine. This component quickly relieves the symptoms of inflammation of the mucous membranes of the upper respiratory tract, eliminates the manifestations of allergies (sneezing, tearing, nasal congestion). In addition, it has a mild calming effect, helps to improve sleep and sets the body to mobilize forces in the fight against the virus.
4. Diphenhydramine is an anti-allergic ingredient. Actively reduces the permeability of the walls of blood vessels, relieves swelling of the mucous membranes and eliminates the feeling of sore throat. Its presence in the composition of the drug allows you to quickly cope with allergic reactions.
5. Rimantadine is an active agent against the type A influenza virus. It blocks its ability to penetrate cells and disrupt their functioning, and does not allow the virus to spread throughout the body. With regard to viral disease type B, it has a powerful antitoxic effect. It does not linger in the body: it is completely excreted by the urinary system three days after ingestion.
6. Calcium gluconate strengthens the vascular wall, helps to stop the inflammatory process in the body.
7. Loratadine is a modern antihistamine. Reduces the release of serotonin, histamine. It relieves itching, swelling, inflammation and does not cause drowsiness.

Thanks to the ingredients described above, Antigrippin quickly copes with all signs of an acute respiratory disease (fever, headache, joint and muscle pain, fever). The drug is recommended to be taken in the first hours of the manifestation of the disease, thus it is possible to significantly reduce its duration and prevent the risk of complications.

Indications for use

Antigrippin is prescribed for the symptomatic treatment of influenza and acute respiratory infections, which are accompanied by fever, headaches, rhinorrhea, myalgia, sore throat and swelling of the nasal mucosa.

Antigrippin is also used for bacterial, viral and allergic rhinitis.

Contraindications

Antigrippin is contraindicated in gastric ulcers, hypersensitivity, severe disorders of the liver and kidneys, angle-closure glaucoma, prostatic hyperplasia, anemia, viral hepatitis, phenylketonuria, leukopenia and alcoholism. Also, this medicine should not be taken during pregnancy and lactation. Effervescent tablets are not prescribed for children under three years of age.

The drug should be taken with caution in elderly patients, as well as those who suffer from hyperoxaluria, alcoholic hepatitis and progressive malignant diseases. Antigrippin for children is contraindicated in children under one year of age.

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy. If necessary, the use of the drug during lactation is recommended to resolve the issue of temporary interruption of breastfeeding.

Instructions for use AntiGrippin

The instructions for use indicate that AntiGrippin is taken orally.

1. Children from 3 to 5 years: 1/2 tablet 2 times a day;
2. Children from 5 to 10 years old: 1 tablet 2 times a day;
3. Children from 10 to 15 years old - 1 tablet 2-3 times a day.

The tablet should be completely dissolved in a glass (200 ml) of warm water (50-60 ° C) and the resulting solution should be drunk immediately. It is better to take the drug between meals. The interval between doses of the drug should be at least 4 hours. The duration of admission without consulting a doctor is not more than 5 days when prescribed as an anesthetic and 3 days as

In patients with impaired liver or kidney function, the interval between doses of the drug should be at least 8 hours.

Instruction for powder

inside. Adults and children over 15 years old - 1 sachet 2-3 times a day.

The contents of the sachet should be completely dissolved in a glass (200 ml) of warm water (50-60°C) and the resulting solution should be drunk immediately. It is better to take the drug between meals. The maximum daily dose is 3 sachets. The interval between doses of the drug should be at least 4 hours.

Side effects

In most cases, when Antigrippin is used in recommended dosages, side effects do not develop. In isolated cases, there may be:

• Anemia, hemolytic anemia (hematopoietic organs);
• Skin rash, urticaria, itching, angioedema (allergic reactions);
• Feeling tired, headache (central nervous system);
• Pain in the epigastric region, nausea (digestive system);
• Hypoglycemia (endocrine system);
• Urinary retention, metabolic disorders, hypervitaminosis, dry mouth, sensation of heat, paresis of accommodation, drowsiness (others).

Overdose

Overdose symptoms often develop when the active components of the drug enter the body. With individual intolerance to paracetamol, overdose symptoms develop after 5-10 hours from the moment of taking the medication.

The clinical picture of an overdose includes the following symptoms:

• vomiting and nausea;
• increased sweating;
• complete or partial loss of appetite;
• stool disorders (diarrhea);
• pain in the abdomen, not having a clear localization.

If an overdose of chlorphenamine has occurred, then the clinical picture includes the following symptoms:

• headache;
• depressive states;
• increased emotional excitability;
• insomnia;
• dizziness;
• convulsions.

special instructions

When taking, it is necessary to take into account the toxic effect of paracetamol on the liver, as well as the effect of vitamins on proliferative diseases:

1. An increase in the side effect of paracetamol on the liver is observed with alcoholic hepatosis;
2. To avoid toxic effects on the liver, you should not combine paracetamol with alcohol or use the drug for people who are prone to alcoholism;
3. When using products containing vitamins, persons suffering from proliferative and metastatic tumors may worsen the course;
4. With prolonged use, it is necessary to monitor the state of peripheral blood, liver and kidneys;
5. When taking metoclopramide (Cerukal), domperidone (Motilium), colestyramine (Questran) at the same time, it is recommended to consult a doctor;
6. When taken, it is possible to distort the results of laboratory data on the level of glucose and uric acid in the blood, the amount of bilirubin, the activity of transaminases and lactate dehydrogenase;
7. Antigrippin contains sugar, which must be taken into account for people with diabetes.

drug interaction

The drug antigrippin and alcohol are incompatible, since ethyl alcohol enhances the effect of the antihistamine component. The use of this medication in combination with antidepressants, antipsychotics and antiparkinsonian drugs leads to the development of adverse reactions from organs and systems.

The simultaneous use of paracetamol and barbiturates leads to a decrease in the therapeutic effect of paracetamol, and accelerates the excretion of ascorbic acid.

Reviews

In most cases, reviews of Antigrippin, including all its dosage forms, are positive. Indeed, this complex of medicinal substances is quite effective for relieving the symptoms of painful conditions of infectious and inflammatory etiology (influenza, SARS), but it needs proper application and strict adherence to the dosage regimen.

Negative manifestations during the use of Antigrippin were most often observed precisely when its dosages or the recommended duration of treatment were exceeded, as well as with the patient's personal sensitivity to its ingredients.

Analogues

Analogues of Antigrippin are:

• By active substances: Antiflu Kids, FluZiOZ-F;
• According to the mechanism of action: Solpadein, Ifimol, Xumapar, Dolaren, AntiFlu, Coldrex, Caffetin, Grippostad, Padevix, Rankof, Paracetamol, Daleron, Apap, Panadol, Gevadal, Novalgin, Coldfree, No-shpalgin, TeraFlu, Pentalgin, Strimol, Prokhodol, Rinzasip, Saridon, Femizol, Flucoldex, Safiston, Flucomp, AjiCOLD, Efferalgan.

Before using analogues, consult your doctor.

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One comment

Powder like powder. The flu does not cure, only relieves the symptoms of a cold. Other paracetamol-based products have the same effect - for example, Ibuklin, and the price cannot be compared with the expensive Naturprodukt. For me personally, everything is obvious and it’s better not to lower the temperature ahead of time, since a lot more microbes burn out than to go around with a flaccid cold without a fever, when the mood is bad, the head is cracking, but you go to work, you don’t take a bulletin, like an employee. You infect others. Now there is an advertisement for the dominance of these remedies for ARVI, although there is a mixture of all known drugs, each of which also has its own side effects and this must be remembered.

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Antigrippin - composition

At the first clinical manifestations of influenza, it is advisable to take combined preparations that combine antiviral components and substances to maintain immunity. These drugs include Antigrippin - the composition of the drug provides rapid relief of the symptoms of the disease, improves well-being and strengthens the body's defenses.

The composition of the pharmaceutical powder Antigrippin

The classic type of drug in question consists of three main ingredients:

The first active substance is a non-steroidal, which has a pronounced analgesic and antipyretic effect, and also helps to relieve pain. In this case, paracetamol does not produce a clear anti-inflammatory effect.

Chlorpheniramine maleate is an antiallergic drug. In addition, the substance has a pronounced sedative effect, due to which vascular spasms are blocked, their permeability improves, and itching is eliminated. Chlorpheniramine also reduces the activity of the glands in the mucous membrane of the nasal sinuses, which reduces the amount of secretion and swelling.

Vitamin C is a well-known antioxidant. Ascorbic acid produces an immunomodulatory effect, protects cells from the negative effects of free radicals and peroxide chemical compounds.

Composition of Antigrippin Maximum

This type of drug is available in the form of gelatin capsules of two colors - red and blue.

In the first case, the composition is as follows:

• rimantadine hydrochloride;
• loratadine;
• rutoside trihydrate;
• vitamin C;
• calcium gluconate monohydrate.

Rimantadine, as you know, has a high antiviral activity, suppresses the causative agents of many infections, including influenza.

Loratadine belongs to antihistamines, therefore, it provides the elimination of such symptoms as itching, swelling, irritation of the mucous membranes. Its effect is enhanced by calcium gluconate.

Rutozid has an anti-inflammatory effect, reduces the fragility and permeability of the walls of blood vessels, improves blood microcirculation.

The blue tablets contain a high dose of paracetomal (360 mg).

This combination of ingredients allows you to quickly cope with the spread of the virus in the body, get rid of unpleasant symptoms.

Ingredients of Antigrippin Anvi

The presented variety of the drug is distinguished by the content of components highly active against influenza viruses:

Metamizole sodium is an analgesic agent. The substance effectively stops the main symptoms of infection, supports immunity. Due to the low anti-inflammatory activity, it is practically non-toxic to the digestive tract.

Dimedrol refers to antiallergic drugs. Produces a pronounced sedative, antispasmodic and local anesthetic effect, quickly relieves itching, irritation of the mucous membranes, inhibits the secretion of the maxillary sinuses.

Composition of homeopathic Antigrippin

Homeopathic granules Antigrippin are considered a special form of the described medicine. They are a combination of mineral and plant components:

In addition to the treatment of viral infections, this Antigrippin is also used for preventive purposes.

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Antigrippin powder for children and adults

Antigrippin refers to a medication that has a symptomatic effect. It is advised to use it to relieve the first signs of a cold. The price of a pharmacy drug ranges from two hundred to three hundred rubles. What is the composition of the drug and who is allowed to use it?

Description of Antigrippin Powder

Antigrippin powder is a combined agent that has antiallergic, analgesic and antipyretic effects.

Antigrippin contains about five hundred milligrams of paracetamol, two hundred milligrams of ascorbic acid and ten milligrams of chlorphenamine maleate.

Paracetamol is a non-steroidal anti-inflammatory drug that has antipyretic and analgesic effects. It quickly relieves elevated body temperature and eliminates pain in the area of ​​muscle and joint structures. In addition, paracetamol helps to relieve the inflammatory process.

Chlorphenamine acts as an antiallergic component. It also has a sedative effect, due to which blocking of vasospasm occurs, improving their permeability and eliminating itching. To all this, this component is able to reduce the activity of the glands in the mucous membrane of the sinuses, as a result of which there is a decrease in the secretion of mucus and the elimination of puffiness.

The body is in great need of ascorbic acid during the development of a cold. It allows you to increase immune strength. Also, vitamin C acts as an antioxidant that protects cells from the adverse effects of microbes.

Indications for the use of Antigrippin and its limitations

Instructions for use Antigrippin indicates that the medication should be taken:

• with chills and the development of a feverish state;
• with congestion of the nasal passages;
• at elevated temperatures;
• with pain in the area of ​​\u200b\u200bmuscle and articular structures;
• with the development of pain in the head;
• with discomfort in the throat and sinuses.

Antiflu is a symptomatic remedy based on paracetamol, but it is not suitable for everyone.

There are several restrictions in the form:

• angle-closure glaucoma;
• severe renal or hepatic insufficiency;
• increased susceptibility to the components of the drug.

Also, Antigrippin in the form of a powder should not be taken:

• with alcoholism;
• with phenylketonuria;
• with prostatic hyperplasia;
• at the age of children up to fifteen years;
• during pregnancy and lactation.

The drug should be used with extreme caution in case of renal or hepatic insufficiency, congenital hyperbilirubinemia, lack of glucose-6-phosphate dehydrogenase, viral hepatitis.

Antigrippin for children

Also on sale is Antigrippin for children. It contains about two hundred and fifty milligrams of paracetamol, fifty milligrams of ascorbic acid and three milligrams of chlorphenamine.

Admission is allowed for children over three years old.

The main indications include:

• elevated body temperature;
• nasal congestion, itching and sneezing;
• pain in muscle and joint structures;
• chills and fever.

It is impossible to take the drug for a long time, as this can lead to the development of unwanted side symptoms in the form of:

• pain in the head;
• feeling tired;
• nausea and pain in the epigastric region;
• hypoglycemia, anemia, thrombocytopenia;
• the occurrence of allergic reactions in the form of rashes on the skin, itching, urticaria, Quincke's edema.

The total duration of the treatment course should not exceed five days.

The use of Antigrippin in the disease

The instruction of Antigrippin indicates that the drug must be taken orally, observing a clear dosage. Before use, the powder must be dissolved in a cup of boiled water. The drink can be taken both hot and warm.

For children over fifteen years of age and adults, you need to take one sachet. You can take the drug up to two or three times a day.

Children under the age of fifteen are prescribed a children's form of medication. The dosage is:

1. babies from three to five years old, half a tablet up to two times a day;
2. children from five to ten years old up to one tablet up to two times a day;
3. adolescents from ten to fifteen years old, one tablet up to three times a day.

The break between the use of the drug should be four to six hours. If the patient has problems with the kidneys or liver, then the interval should be increased to eight hours.

The duration of admission as an anesthetic is five days, and as an antipyretic up to three days.

Antigrippin's analogs

This medication acts only as a medicine to relieve the symptoms of a cold. He is not able to cure diseases, but only temporarily eliminate unpleasant symptoms.

In medicine, there are good analogues of Antigrippin.

This includes Antigrippin Maximum. This is a combined medication, which includes:

1. calcium gluconate. Refers to a mineral supplement that leads to an increase in calcium levels. The impact is aimed at preventing vascular fragility and capillary permeability;
2. rimantadine. This component refers to an antiviral agent. Its effect is aimed at lowering the intoxication of the body, stimulating the production of interferon in the blood;
3. rutoside. This component allows you to reduce the permeability of the vascular system, as well as relieve swelling and inflammation;
4. loratadine. This component belongs to antihistamines. It allows you to quickly remove puffiness and other allergic reactions.

Antigrippin Maximum is considered an excellent drug, as it has anti-inflammatory, antiviral, antipyretic and analgesic effects.

Another analogue is Antigrippin Anvi. It does not include paracetamol and chlorphenamine.

The main components are:

• acetylsalicylic acid. It has an antipyretic and analgesic effect. Removes the inflammatory process and prevents the development of thrombosis;
• metamizole sodium. Acts as an analgesic and anti-inflammatory component;
• diphenhydramine. This component refers to an antihistamine that allows you to relieve swelling, eliminate itching and resume nasal breathing. It is also used to relieve spasm of blood vessels, vomiting.

It has a number of restrictions in the form:

• the presence of ulcers in the stomach and intestines;
• children's age up to fifteen years;
• tendency to bleed;
• lack of vitamin K;
• increased susceptibility to the components of the drug.

Another analogue is Antiflu. It is a drug that has a symptomatic effect. The drug has analgesic, antipyretic, antiallergic, anti-inflammatory and vasoconstrictive properties.

Sold in the form of tablets and powder, which include paracetamol, phenylephrine, chlorphenamine.

It has many restrictions such as:

• increased susceptibility to the components of the drug;
• renal and hepatic insufficiency;
• portal hypertension;
• alcoholism;
• the period of gestation and lactation;
• children's age up to six years for tablets and seventeen years for powder.

Also, the medication should be used with extreme caution for angle-closure glaucoma, bronchial asthma, chronic lung disease, blood disease, diabetes mellitus and prostate adenoma.

In some cases, with an overdose or prolonged use, the drug leads to the development of side symptoms in the form of:

• rashes on the skin, itching and burning;
• sleep disorders;
• pain in the head and dizziness;
• feeling tired;
• nausea and vomiting.

In most cases, Antigrippin powder is well tolerated. But if side effects develop, then it must be replaced with an analogue. It is worth noting that this medication is not a drug and allows you to only briefly relieve the symptoms of a cold. Therefore, medical therapy is required.

Antigrippin: instructions for use of powder and tablets

Active ingredient: Paracetamol,

chlorphenamine, ascorbic acid

Manufacturer: Natur Product Pharma, Poland

Pharmacy dispensing condition: Without a prescription

Antigrippin is a pharmaceutical drug with a combined composition that exhibits antihistamine, anti-inflammatory, antipyretic properties.

Indications for use

Antigrippin in powder and tablets is prescribed for use in the treatment of ailments of a viral and bacterial nature (colds, SARS, influenza), during which the following is observed:

• Feverish state
• Rhinitis and nasal congestion
• Pain in the muscles and joints, sinuses and throat
• Strong headache.

Compound

Antigrippin powder contains 3 active ingredients:

• Paracetamol at a dose of 500 mg
• Ascorbic acid in the amount of 200 mg
• Chlorphenamine 10 mg.

Pharmacy list of additional components:

• Povidone
• Sweeteners (aspartame, sucrose)
• Sorbitol
• Lemon acid
• Potassium cesulfame
• Docusate and sodium cyclamate
• sodium bicarbonate
• Flavoring agents (chamomile extract, caramel, honey and lime additive).

Antigrippin for adults (tablets) contains the same active ingredients and in the same amount as in the powder. Additionally present:

• Sodium bicarbonate, saccharinate and carbonate
• Citric acid
• macrogol
• Sodium lauryl sulfate
• Sorbitol
• aromatic component
• Povidone.

Antigrippin for children in the form of effervescent tablets includes:

• Paracetamol - 250 mg
• Ascorbic acid - 50 mg
• Chlorphenamine in the form of maleate - 3 mg.

Each tablet is enriched with such components (as the abstract says):

• Sodium bicarbonate and saccharin
• silicon dioxide
• sodium carbonate
• Sorbitol
• Lemon acid
• macrogol
• Povidone
• Fruit flavor.

Medicinal properties

The drug from Natur Product contains a combined composition, it is he who ensures the effectiveness of therapeutic therapy for infectious and inflammatory diseases.

Paracetamol is one of the analgesics included in the group of analides, it exhibits antipyretic properties. Its action is aimed at lowering body temperature in case of heat, anesthesia with severe pain syndrome of various localization.

Chlorphenamine is included in the group of blockers of specific H1 receptors, which characterizes its pronounced antihistamine properties. In addition, this substance normalizes full nasal breathing, eliminates the feeling of itching, excessive tearing, and sneezing.

Ascorbic acid, which is a synthetic analogue of vit. C, participates in the regulation of carbohydrate metabolism and redox reactions. With this effect, the endogenous resistance of the human body increases.

Release form

Powder price: from 93 to 531 rubles.

Antigrippin powder for making a solution is packaged in a sachet (5 g) and has a honey-lemon or chamomile flavor. Inside the pack contains 3, 10, 12 or 24 sachets.

Antigrippin effervescent tablets with grapefruit or raspberry flavor are packed in cellless packs of 2 pcs. Inside the pack there are 5 packs of tablets.

Antigrippin for children is produced in the form of rich pink tablets, they are placed in blisters or plastic cases of 10 pcs. A cardboard pack may contain 3 blisters or one plastic case.

Antigrippin: instructions for use

The price of tablets for adults: from 250 to 562 rubles.

The use of Antigrippin from Natur Product involves diluting the powder or tablets in slightly warmed water (210 ml) and taking the resulting solution inside.

Reception of Antigrippin should be carried out with a time interval of 4 hours, in case of violations of the renal system and liver, this time is doubled.

The duration of the use of Antigrippin Naturprodukt as an analgesic is 5 days, as a thermoregulatory agent - 3 days.

Before taking Antigrippin tablets or powder, you should discuss the advisability of treatment with your doctor.

Antigrippin for children: instructions for use

The price of tablets for children: from 113 to 558 rubles.

Not all parents know whether children can drink Antigrippin, take the drug in the first-aid kit or not.

Antigrippin in a dosage for children is prescribed according to a certain scheme, taking into account age:

• Children of the younger age group (3-5 years) should take ½ tab. twice a day
• Children of the middle age group (5-10 years old) are prescribed 1 tab. twice a day
• Children of the older age group are required to take 1 tab. three times a day.

During the use of the drug Antigrippin for children, it is necessary to provide the child with a strict drinking regimen and control how he drank the drug. In some cases, the dose of Antigrippin can be adjusted. Anti-inflammatory sprays may be used.

Antigrippin during pregnancy and breastfeeding

There is no information about the condition of women taking the drug, so Antigrippin is not prescribed during pregnancy, lactation.

Contraindications

• Excessive susceptibility to the components of tablets, powder
• Phenylketonuria
• Ulcerative diseases of the digestive tract
• Pregnancy, breastfeeding
• Serious violations of the functioning of the liver, renal system
• Presence of angle-closure glaucoma
• Alcohol abuse
• Hyperplasia of the prostate tissue
• Children's age (up to 3 years - tablets for children, up to 15 years - granules and tablets for adults).

Precautionary measures

With extreme caution, you should drink the medicine when:

• Deficiency of glucose-6-phosphate dehydrogenase
• Pathologies of the functioning of the kidneys, as well as the liver
• Diagnosing hyperbilirubinemia
• Viral and alcoholic hepatitis
• old age
• Signs of hyperoxalaturia
• Detection of malignant neoplasms.

Cross-drug interactions

Before using drugs such as domperidone, cholestyramine or metoclopramide, you will need to consult with your doctor. When taking increased dosages of drugs, the risk of developing disorders of the renal system and liver increases.

Antigrippin and alcohol are not compatible with each other.

Side effects

When taking Antigrippin, negative manifestations develop in isolated cases:

• Lethargy, headaches
• Epigastric pain, severe nausea
• Occurrence of hypoglycemia
• Low hemoglobin
• Skin rashes, Quincke's edema
• Urinary retention, metabolic disorders, feeling of dryness in the oral cavity, hypervitaminosis state, drowsiness.

Overdose

When taking increased dosages of the drug, the development of diarrhea, hyperhidrosis, abdominal and epigastric pain (occurs against the background of an overdose of paracetamol) can be observed. The intake of high doses of chlorphenamine provokes convulsive syndrome, dizziness, insomnia, depression.

Treatment for such symptoms is aimed at stopping the side effects of taking the medication.

Storage conditions and shelf life

The drug in the form of powder and tablets can be stored at temperature C for 3 years.

Analogues

Antigrippin-ANVI

Antigrippin-ANVI is a drug with a combined composition, has analgesic, thermoregulatory and antihistamine properties. Antigrippin-ANVI is used for symptomatic therapy for acute respiratory viral infections, influenza. Release form - capsules.

• low price
• Complex action
• Antigrippin-ANVI is available without a prescription.

• Designed for children from 15 years old
• Contraindicated in bronchial asthma
• Antigrippin-ANVI is not recommended to be combined with indirect anticoagulants.

Powder Antigrippin is a remedy for the symptomatic treatment of diseases in which the patient has a fever and develops local inflammation with severe pain.

On sale, Antigrippin in powder is positioned as a drug for the treatment of influenza, in the instructions for it, SARS and colds are indicated as indications, but in fact it does not have a narrow focus of action. When applied, it allows only for a while to reduce the patient's temperature and relieve pain at the site of inflammation, that is, it allows you to temporarily alleviate the symptoms common to many diseases. For this reason, it can be used to temporarily alleviate symptoms not only with influenza and other acute respiratory viral infections, but also with various bacterial diseases, as well as other syndromes accompanied by pain and fever, for example, with toothache, herpes zoster and others.

What is included in the composition of the powder and what result can be expected from its use?

The composition of the powder Antigrippin includes the same components as in the composition:

1. Paracetamol is a substance with antipyretic, analgesic and anti-inflammatory properties, in fact, the main active ingredient of the drug. Its action lasts 4-6 hours, after which the symptoms of the disease can resume;
2. Chlorphenamine maleate is an antiallergic component, an antihistamine. It has a slight decongestant effect and may somewhat reduce the amount of mucus released during a runny nose, but its effect is not enough to restore normal nasal breathing in a typical ARVI;
3. Ascorbic acid - as part of the product is positioned as a component to strengthen and quickly restore immunity. These qualities are somewhat exaggerated: despite its participation in the work of the immune system, it is not capable of influencing the course of viral respiratory diseases, and therefore it was added to the composition of the drug mainly to create an image of a complex agent in it.

Chamomile extract is also added to the composition of the powder with chamomile, which exhibits anti-inflammatory activity when taken.

Chamomile powder sachet

In fact, when used, Antigrippin in powder causes the same effects as drugs based on Paracetamol alone - it temporarily lowers the temperature, relieves pain and inflammation. At the same time, its price is much higher than the price of Paracetamol preparations. For example, a package for 5 bags of Antigrippin powder costs about 140 rubles, it is enough for 5 doses. The price of a bottle of Paracetamol suspension per 100 ml (5-10 doses) costs 55-65 rubles.

Taking Antigrippin powder will not reduce the duration of the disease, and will not prevent the development of complications in viral and bacterial infections. The drug has no effect on viruses or bacteria.

Is it possible to use a remedy for the prevention of influenza and SARS?

Who can use Antigrippin Powder?

Antigrippin Powder is intended for use only by adults and adolescents over 15 years of age. Children under 15 years of age are prescribed with a lower content of active ingredients, or analogues of the drug in the form of a powder (for example, Antiflu Kids).

For children, under the brand name Antigrippin, special effervescent tablets are produced, which, like powder, dissolve in water to make syrup.

Indications for taking the drug

Antigrippin is used only in the presence of severe symptoms of the disease, accompanied by an inflammatory process:

• With an increase in body temperature above 38 ° C;
• With severe pain of various localization;
• With swelling of the nasopharynx with SARS or influenza, severe inflammation of the tonsils, laryngitis, tracheitis and other inflammations.

If the patient does not have any of these symptoms, taking the powder is not only pointless, but can also be harmful.

Types of Antigrippin powders

Powder Antigrippin is available in two versions with different flavors:

• Powder with the addition of chamomile extract. The price of a package for 10 bags is about 300 rubles;
• Powder with honey and lemon flavor. The price of a package for 10 bags is about 280 rubles, for 6 bags - 200 rubles, for 3 bags - about 110 rubles.

The effectiveness and effect of both types of powder are almost the same, the presence of an extract of pharmaceutical chamomile, if it increases the anti-inflammatory properties of the agent, is not significant. If you follow the instructions for use, any of them can be used to treat ARVI. 2-3 sachets per day are required, respectively, for the treatment of one episode of influenza, approximately 6-8 sachets will be required.

Dosage and order of administration

Antigrippin powder from one sachet is taken 2-3 times a day. For use, the powder is dissolved in a glass of clean, slightly warmed water, mixed and drunk immediately. It is advisable to drink the remedy between meals for better absorption of its components.

Contents of one sachet of Antigrippin

The drug is taken no more than once every 4 hours, and no more than 3 sachets per day. If, after 4-6 hours after the previous dose, the symptoms did not recur, or turned out to be much weaker, such that the patient can normally endure them, Antigrippin should not be taken again. The next appointment is carried out with the next significant exacerbation of symptoms - increased pain or an increase in temperature above 38 ° C.

When taking Antigrippin, you need to drink as much pure water, tea, juices or compotes as possible. This will ensure profuse sweating and a more effective reduction in temperature.

After taking Antigrippin, you should not drink alcohol. Instructions for use indicate alcoholism as one of the contraindications to taking this drug.

For patients with impaired renal and hepatic function, the interval between doses of the powder should be more than 8 hours.

If Antigrippin powder is taken for 5 days in a row to relieve pain of one or another localization and nature (for example, with sore throat, with toothache, with pain in the head), and the pain itself has not gone away during this time, the patient needs to see a doctor. Self-administration of the drug as an anesthetic for more than 5 days in a row is prohibited.

Likewise, do not take Antigrippin powder to reduce fever for more than 3 days in a row without consulting a doctor. If during this time the temperature has not decreased, it is necessary to find out the causes of the disease and, possibly, carry out etiotropic treatment under the guidance of a doctor.

Contraindications to taking the drug

Antigrippin powder should not be taken by children under 15 years of age, pregnant women and breastfeeding mothers. These contraindications are mainly due to the presence of chlorphenamine in the drug, which can have an undesirable effect on the child's body, as well as on the fetus when taken by a pregnant woman.

Also, the powder cannot be used for glaucoma, allergies to any component of the product, for renal and hepatic insufficiency, and for prostate dysplasia.

Possible side effects

Antigrippin powder rarely causes side effects. In isolated cases, allergic reactions in the form of a rash, nausea and abdominal pain, dry mouth, and drowsiness are noted. Some of them require discontinuation of the drug, with some, the drug can be continued. The decision to cancel or replace the powder with such side effects is made only by the doctor.

What means can replace Antigrippin powder?

A complete analogue of Antigrippin powder in terms of the set of active ingredients is Antiflu Kids powder. The difference between them lies in the number of active ingredients and the indications of the funds: Antiflu Kids is intended for children and contains the main components in smaller dosages. Its action is similar to that of Antigrippin.

Antiflu Kids is produced by another company, but its composition is similar to that of Antigrippin.

Powders with the taste of raspberry, lemon and lemon with honey also have a similar composition. The components of Antigrippin Maximum are different, but the effect of their use is similar to that when taking a simple Antigrippin.

In fact, the same effect that Antigrippin has can be obtained using simple Paracetamol in powder or suspension, as well as Nurofen, Panadol or Efferalgan. These drugs are cheaper than Antigrippin and safer, they can be used, among other things, in the treatment of diseases in children, and, as directed by a doctor, for pregnant women and breastfeeding mothers. The difference between them and Antigrippin is the absence of ascorbic acid and chlorphenamine, the expediency of which in ARVI is doubtful, but because of which, in fact, Antigrippin is much more expensive than simpler drugs.

Active substances:

paracetamol - 500 mg

chlorphenamine maleate - 10 mg

ascorbic acid - 200 mg

Excipients:

Honey Lemon:

sodium bicarbonate, citric acid, sorbitol, povidone, sucrose, sodium cyclamate, aspartame, acesulfame potassium, lime flavor (Lime aromatic fruit additive), caramel flavor, honey flavor, sodium docusate.

Chamomile:

sodium bicarbonate, citric acid, sorbitol, povidone, sucrose, sodium cyclamate, aspartame, acesulfame potassium, chamomile extract, docusate sodium.

Description

Honey-lemon powder: powder of varying degrees of granulation,

consisting of particles from white to grayish-beige, with a specific odor. Dark brown blotches are allowed. Chamomile powder: powder of varying degrees of granulation, consisting of particles from white to beige and light brown in color, with a specific odor. Brown blotches are allowed.

pharmachologic effect

Combined preparation consisting of three active substances.

Paracetamol has an analgesic and antipyretic effect; eliminates headache and other types of pain, reduces fever.

Chlorphenamine maleate is an antihistamine, an H1-histamine receptor blocker, a propylamine derivative, has an anticholinergic effect. Antihistamines that exhibit H1-histaminolytic properties have the ability to reversibly competitive antagonize histamine in the tissues of the skin, lungs, intestines, and blood vessels. The sedative effect of chlorphenamine maleate is due to its penetration through the blood-brain barrier. The adrenolytic property may increase the risk of orthostatic hypotension.

Possessing an anti-allergic effect, it facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, tearing, itching and redness of the eyes.

Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, increases the body's resistance.

Indications for use

Symptomatic treatment of acute respiratory viral infections, influenza, rhinitis, accompanied by fever, chills, headache, pain in the joints and muscles, nasal congestion and pain in the throat and sinuses.

Contraindications

Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug;

Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);

Severe renal and / or liver failure;

Alcoholism;

Angle-closure glaucoma;

Hyperplasia of the prostate;

Children's age (up to 15 years);

Pregnancy (I and III trimester) and lactation.

With caution: renal and / or liver failure, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), hyperoxalaturia, progressive malignant diseases, viral hepatitis, alcoholic hepatitis, old age.

Dosage and administration

inside. Adults and children over 15 years old: 1 sachet 2-3 times a day. The contents of the sachet should be completely dissolved

take the drug between meals. The maximum daily dose is 3 sachets. The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between doses of the drug should be at least 8 hours.

The duration of admission without consulting a doctor is not more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic.

Shout in a glass (200 ml) of warm water (50-60 ° C)

Side effect

In isolated cases, there are effects:

Associated with the presence of paracetamol

There have been some rare cases of immediate hypersensitivity reactions: anaphylactic shock, Quincke's edema, erythema,

urticaria, skin rash. If these symptoms occur, you should immediately stop taking this drug and its related drugs. In very rare cases, thrombocytopenia, leukopenia and neutropenia have been reported.

Associated with the presence of chlorphenamine maleate

The pharmacological characteristics of chlorphenamine underlie the side effects of varying degrees of intensity, which are associated or not associated with the dosage of the drug.

From the autonomic nervous system:

Calmness or drowsiness, more pronounced at the beginning of treatment;

orthostatic hypotension;

Anticholinergic effect: dry mucous membranes, constipation, disturbance of accommodation, dilated pupils, palpitations, urination disorder (dysuria, urinary retention);

Balance disorders, dizziness, decreased memory or concentration, more common in the elderly;

Disorder of coordination of movements, trembling;

Confusion of consciousness, hallucinations.

Hypersensitivity reactions:

Erythema, eczema, severe itching, purpura;

Less commonly, Quincke's edema;

Anaphylactic shock.

From the blood-forming organs."

Leukopenia, neutropenia;

Thrombocytopenia;

hemolytic anemia.

All side effects of the drug should be reported to the doctor.

Overdose

Symptoms of an overdose of chlorphenamine maleate: dizziness, agitation, sleep disturbance, depression, convulsions.

Paracetamol overdose symptoms: nausea, vomiting, loss of appetite, pallor, abdominal pain. These symptoms usually appear within the first 24 hours.

An overdose, starting with 10 g of paracetamol at a time for an adult and 150 mg per 1 kg of body weight at a time for a child, leads to liver cytolysis, which can lead to complete and irreversible liver necrosis, manifested in liver failure, metabolic acidosis, encephalopathy up to coma and death.

At the same time, there is an increase in the level of hepatic transaminases, lactodehydrogenases, bilirubin and a decrease in the level of prothrombin, which can occur 12-48 hours after taking the drug.

Urgent care:

Immediate transfer of the patient to the hospital;

Collecting a blood test in a test tube to determine the initial concentration of paracetamol in plasma;

Rapid elimination of the medication taken by flushing

Treatment of paracetamol overdose usually involves giving the antidote N-acetylcysteine ​​intravenously or orally as early as possible, if possible within the first ten hours after taking the drug;

symptomatic treatment.

The literature describes isolated cases of acute and chronic overdose of ascorbic acid in patients with glucose-6-phosphate dehydrogenase deficiency. With DIC, an overdose of ascorbic acid can lead to a significant increase in the level of oxalate in the blood serum and urine. An increase in blood oxalate levels in patients on hemodialysis can lead to the deposition of calcium oxalate deposits.

Interaction with other drugs

Paracetamol

The interaction of paracetamol and inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increases the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications with small overdoses.

Against the background of taking paracetamol pancreatitis.

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxicity.

Simultaneous administration of diflunisal and paracetamol increases the plasma concentration of the latter by 50%, increasing

hepatotoxicity. Simultaneous reception of barbiturates reduces the effectiveness of paracetamol.

Paracetamol reduces the effectiveness of uricosuric drugs. Paracetamol at high doses (4 g/day) for more than 4 days may potentiate the effect of oral anticoagulants and therefore increase the risk of bleeding. Constant monitoring of the INR (International Normalized Ratio) is required. It is necessary to take into account the use of paracetamol when co-administered with oral anticoagulants and the discontinuation of paracetamol. Chlorphenamine maleate

Chlorphenamine maleate can enhance the inhibitory effect on the central nervous system of many drugs and substances, slowing down the speed of reaction and reducing concentration. These are morphine derivatives (analgesics, antitussives), neuroleptics, tranquilizers, barbiturates, benzodiazepines (for example, meprobamate, diazepam), hypnotics, sedative antidepressants (amitriptyline, doxepin, mianserin, mirtazapine, timipramine), sedative antihistamines H1-blockers, antihypertensive drugs central action, baclofen, thalidomide.

Glucocorticosteroids - increase the risk of developing glaucoma.

Ethanol enhances the sedative effect of chlorphenamine maleate.

Vitamin C

Increases the concentration in the blood of benzylpenicillin and tetracyclines;

Improves absorption in the intestines of iron preparations (converts ferric iron to ferrous); may increase iron excretion when used concomitantly with deferoxamine;

Increases the risk of developing crystalluria in the treatment of salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood;

Increases the overall clearance of ethanol;

With simultaneous use reduces the chronotropic effect of isoprenaline.

It can either increase or decrease the effect of anticoagulant drugs. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Simultaneous administration of barbiturates increases the excretion of ascorbic acid in the urine.
With the simultaneous use of deferoxamine with ascorbic acid in high doses intravenously, it is possible to develop cardiac dysfunction or acute heart failure (usually reversible after stopping vitamin C). The use of vitamin C in hemochromatosis is possible only after the start of treatment with deferoxamine under the control of heart function.

Such a nuisance as acute respiratory diseases can happen to each of us at any time of the year. Most often, we suffer not from the attack of colds, but from the defeat of viruses, which not only greatly worsen our general condition, but are also fraught with the development of a variety of complications. Of course, such pathological conditions should not be ignored, it is best to treat them under the supervision of a doctor. Therapy of acute respiratory infections and acute respiratory viral infections, including influenza, may include the use of a variety of medicinal formulations, including Antigrippin (powder).

What is the action of Antigrippin?

Antigrippin is a complex medicinal composition that can relieve fever and eliminate inflammation. In addition, such a remedy well eliminates swelling of the mucous membranes in the nasal cavity, copes with manifestations of allergies and other symptoms of a cold.

What is the composition of Antigrippin?

Pharmacy powder Antigrippin contains paracetamol, vitamin C or in other words ascorbic acid, as well as chlorpheniramine maleate. Paracetamol is an anti-inflammatory drug, it is able to eliminate unpleasant painful sensations, as well as reduce fever. Such a component of this medication as chlorpheniramine maleate is inherently a blocker of H1-histamine receptors, it copes with the manifestations of allergies and has sedative qualities. In addition, its consumption leads to a decrease in mucus production. Chlorphenamine also helps to ease the processes of nasal breathing by an order of magnitude, reduce the feeling of nasal congestion, relieve the patient from sneezing, tearing, itching and redness of the eyes.

Ascorbic acid is a strong antioxidant, it stimulates the immune system and reduces vascular permeability quite well. Vitamin C also takes an active part in the regulation of redox processes and is important for the normal course of carbohydrate metabolism.

One sachet of Antigrippin powder contains five hundred milligrams of paracetamol, ten milligrams of chlorphenamine maleate and two hundred milligrams of ascorbic acid.

The drug can be purchased in two different forms - with honey-lemon or chamomile flavor.

What are the indications for use of Antigrippin?

Antigrippin can be used in the treatment of various infectious and inflammatory diseases, for example, various types of acute respiratory viral infections and influenza, which are accompanied by fever, chills and headaches, aching joints and muscles, as well as nasal congestion and pain in the throat and nasal sinuses.

What is the use and dosage of Antigrippin?

This drug is suitable for the treatment of adults and children over the age of fifteen. At the same time, it is allowed to consume no more than two or three sachets of the drug per day. The medicine powder should be completely dissolved in one glass of slightly heated water (no higher than fifty or sixty degrees). The prepared composition should be drunk immediately. It is highly recommended to consume the solution between meals.

Between doses of the medicinal composition, an interval of at least four hours must be observed.

If the patient has impaired liver or kidney activity, or if his age has exceeded fifty years, then the interval between the consumption of the medication should be at least eight hours.

The duration of consumption without consulting a doctor should not exceed five days if the medicine is used for pain relief. With temperature correction, this period is reduced to three days.

What are the contraindications for Antigrippin?

Powder Antigrippin instructions for use does not allow the use if the patient has excessive sensitivity to any of its components. Also, this drug is not used in the treatment of patients with erosive and ulcerative lesions of the digestive tract at the stage of exacerbation, a severe form of renal or hepatic insufficiency. This medication is not suitable for patients with alcoholism, angle-closure glaucoma, phenylketonuria, prostatic hyperplasia. Antigrippin is not customary to use in the treatment of children under the age of fifteen, in addition, its consumption is contraindicated when carrying a child, as well as at the stage of breastfeeding.

Particular care should be taken with renal or hepatic insufficiency, congenital hyperbilirubinemia, lack of glucose-6-phosphate dehydrogenase, viral hepatitis, alcoholic hepatitis and in old age.

What are the side effects of Antigrippin?

Antigrippin rarely causes side effects, in most cases it is well tolerated by the body. However, in some cases, its consumption can lead to headaches and fatigue, provoke nausea and pain in the epigastric region. The development of hypoglycemia, anemia and hemolytic anemia is extremely rare, and thrombocytopenia is even rarer. In some cases, Antigrippin provokes various kinds of allergic reactions, including skin rashes, itching, urticaria, Quincke's edema, etc. Some patients develop hypervitaminosis C, metabolic problems, a feeling of heat and dryness in the oral cavity. Sometimes there may be paresis of accommodation, excessive drowsiness and urinary retention.

The appearance of any side effect should be considered as a reason for an immediate consultation with a doctor.