How many tablets to take caffeine sodium benzoate. Caffeine Pills Are A Serious Stimulant

The product is produced in the form of tablets in a blister pack. The main substance is caffeine (in the form of sodium benzoate).

The drug Caffeine in tablets has a psychostimulating, analeptic, cardiotonic effect. The excitatory effect on the central nervous system, which manifests Caffeine in tablets, excites the vasomotor and respiratory centers, causes an increase in the reflex excitability of the spinal cord, enhances and regulates excitation processes in the cerebral cortex.

As a result, physical and mental performance increases, drowsiness and fatigue decrease, the strength and frequency of heart contractions increase, which is especially evident in large doses. With hypotension, without changing the normal pressure, the drug is able to increase blood pressure. In addition, the blood vessels of the skeletal muscles, kidneys, heart, bronchi and narrowing of the abdominal organs expand. The secretory function of the stomach at the same time increases, platelet aggregation decreases. The agent blocks peripheral and central adenosine receptors and exhibits a moderate diuretic effect, stabilizes transmission in beta-adrenergic synapses of the medulla oblongata and hypothalamus, dopaminergic synapses, noradrenergic synapses, cholinergic synapses of the medulla oblongata and cortex.

The effectiveness of koin in tablets significantly depends on the type of the patient's nervous system, and therefore should be prescribed taking into account the individual characteristics of a person's nervous activity.

Indications for the use of caffeine tablets

The agent is prescribed for the treatment of diseases in which the functions of the central nervous system, respiratory system, cardiovascular system are inhibited, including drug poisoning, infectious diseases and others.

Caffeine is also used for spasms of cerebral vessels, to increase physical and mental performance, for respiratory disorders, to eliminate drowsiness, enuresis in children.

Contraindications

The agent is not prescribed for organic diseases of the cardiovascular system, including atherosclerosis, severe arterial hypertension, irritability, sleep disorders, glaucoma, old age.

Side effects

When using the drug, manifestations of agitation, anxiety, increased blood pressure, tachycardia, insomnia, arrhythmias, nausea and vomiting are possible. Prolonged use of the drug is fraught with possible weak addiction. At the same time, it decreases, which is due to the formation of new adenosine receptors in brain cells. Sudden cessation of caffeine use may increase the inhibition of the central nervous system, resulting in fatigue, depression and drowsiness.

The use of caffeine tablets and doses

The agent is prescribed orally at 25-100 milligrams up to three times a day.

For adults, the maximum single dose is 0.4 grams, and the daily dose is 1 gram.

The agent reduces the effectiveness of narcotic and hypnotic drugs, but increases, due to improved bioavailability, paracetamol, acetylsalicylic acid, and other non-narcotic analgesics. The drug improves the absorption of ergotamine in the gastrointestinal tract.

Overdose

In case of excessive use of caffeine (more than 0.3 grams per day, which corresponds to four 150 ml), anxiety, anxiety, confusion, tremor, headache, cardiac extrasystoles may occur.

ABON BIOPHARM (Hangzhou) Co., LTD BELMED PREPARATY, RUE Beringer Ingelheim Pharma GmbH and Co. KG Semashko Moscow Chemical Pharmaceuticals named after N.A. Semashko, OJSC POLYPHARM ICN POLYPHARM, LLC Tatkhimpharmaceuticals OJSC THPZ ICN Usolie-Sibirsky Chemical Pharmaceutical Plant, OJSC Pharmstandard-Tomskchimpharm, OJSC

Country of origin

Republic of Belarus Russia

Product group

Nervous system

Psychostimulant and analeptic.

Release form

1 ml - ampoules (10) - packs of cardboard. 6 - non-cell packing contour. 6 - non-cell packing contour. tablets ao 100.0 mg --- 10 pieces in a blister pack

Description of the dosage form

Solution for s / c and subconjunctival administration Tablets White tablets of a flat-cylindrical shape with a chamfer and a risk.

pharmachologic effect

Caffeine is a methylxanthine that has a psychostimulant and analeptic effect. Competitively blocks central and peripheral AT and A2 adenosine receptors. It inhibits the activity of phosphodiesterases in the central nervous system, heart, smooth and striated muscle tissue, adipose tissue, contributes to the accumulation of cisic adenosine monophosphate and cyclic guanosine monophosphate in them (this effect is observed when only high doses of caffeine are used). Stimulates the centers of the medulla oblongata (respiratory and vasomotor), as well as the center of the vagus nerve, has a direct stimulating effect on the cortex, the brain. In high doses, it “facilitates. Interneuronal conduction in the spinal cord, enhancing reflexes. Increases mental and physical performance, stimulates mental activity, motor activity, shortens reaction time, temporarily reduces fatigue and drowsiness. oppression of the nervous system.It speeds up and deepens breathing, usually has a positive ino-, chrono-, batmo- and dromotropic effect (since the effect on the cardiovascular system consists of a direct stimulating effect on the myocardium and a simultaneous excitatory effect on the center of the vagus nerve, resulting the effect depends on the predominance of one or another action.) Stimulates the vasomotor center and has a direct relaxing effect on the vascular wall, which leads to the expansion of the vessels of the heart, skeletal muscles and kidneys, while the tone of the cerebral arteries increases (causes vasoconstriction of the brain, which caused by a decrease in cerebral blood flow). Arterial pressure changes under the influence of vascular and cardiac mechanisms of caffeine influence: caffeine does not change or slightly increases it at normal initial arterial pressure, at arterial hypotension it increases it. It has an antispasmodic effect on smooth muscles (including a bronchodilating effect), on the striated - stimulating. Increases the secretory activity of the stomach and diuresis (decrease in the reabsorption of sodium and water in the proximal and distal renal tubules, as well as vasodilation of the kidneys and increased filtration in the renal glomeruli). Reduces platelet aggregation and release of histamine from mast cells. Increases basal metabolism: increases glycogenolysis, increases lipolysis.

Pharmacokinetics

When taken orally, absorption is good; occurs throughout the intestine. It is rapidly distributed in all organs and tissues of the body, penetrates the blood-brain barrier and the placenta. The maximum concentration in blood plasma is reached in 50-75 minutes; the half-life is 3.9-5.3 hours (sometimes up to 10 hours). Communication with blood proteins (albumins) - 15%. Metabolism in the liver is more than 90%, in children of the first years of life up to 10-15%. Caffeine is metabolized in the liver (the main part is dimethylated and oxidized) with the formation of 5 metabolites. Excretion of caffeine and its metabolites is carried out by the kidneys (10% unchanged).

Special conditions

It should be borne in mind that a sudden cessation of administration can lead to increased inhibition of the central nervous system (drowsiness, depression). The effect on the central nervous system depends on the type of nervous system and can be manifested both by excitation and inhibition of higher nervous activity. Due to the fact that the effect of caffeine on blood pressure consists of vascular and cardiac components, as a result, both the effect of stimulating the heart and oppression (weak) of its activity can develop. Do not take before bed. Influence on the ability to drive transport. cf. and mechanisms During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require concentration and speed of psychomotor reactions.

Compound

1 ml caffeine sodium benzoate 200 mg caffeine 0.1 g; Auxiliary substances: potato starch, calcium stearate

Caffeine-sodium benzoate indications for use

Diseases accompanied by depression of the central nervous system, functions of the cardiovascular and respiratory systems (including poisoning with opioid analgesics, infectious diseases), spasms of cerebral vessels, decreased mental and physical performance, drowsiness.

Caffeine-sodium benzoate contraindications

Arterial hypertension, organic diseases of the cardiovascular system (including severe atherosclerosis), glaucoma, irritability, sleep disturbances, old age.

Caffeine-sodium benzoate dosage

0.1 g 100 mg 200 mg/ml

Caffeine sodium benzoate side effects

From the side of the central nervous system: psychomotor agitation, anxiety, tremor, anxiety, headache, dizziness, epileptic seizures, increased reflexes, tachypnea, insomnia; with sudden cancellation - increased inhibition of the central nervous system, increased fatigue, drowsiness, muscle tension. From the side of the cardiovascular system: palpitations, tachycardia, increased blood pressure. From the digestive system: nausea, vomiting, exacerbation of peptic ulcer. Other: nasal congestion, with prolonged use - addiction, drug dependence.

drug interaction

Caffeine is an adenosine antagonist (large doses of adenosine may be required). With the combined use of caffeine and barbiturates, primidone, anticonvulsant drugs (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase clearance of caffeine; cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver .. (slowing its excretion and increasing blood concentrations). Caffeinated drinks and other drugs that stimulate the central nervous system - excessive stimulation of the central nervous system is possible. - Mexiletine - reduces the excretion of caffeine by 50%; nicotine - increases the rate of excretion of caffeine. Monoamine oxidase inhibitors, furazolidone, procarbazine and selegiline - large doses of caffeine (more than 300 mg / day) can cause the development of life-threatening cardiac arrhythmias or - a pronounced increase in blood pressure. Caffeine reduces the absorption of calcium preparations in the gastrointestinal tract. Reduces the effectiveness of narcotic and hypnotic drugs. Increases the excretion of lithium preparations in the urine; Accelerates absorption and enhances the action of cardiac glycosides, increases their toxicity. Joint use with beta-blockers can lead to mutual suppression of therapeutic effects; with?-agonists - to additional stimulation of the central nervous system and other additive toxic effects. Caffeine may decrease clearance; theophylline and possibly other xanthines, increasing the possibility of additive pharmacodynamic and toxic effects.

Storage conditions

store in a dry place
store at room temperature 15-25 degrees
keep away from children

Information provided

The modern rhythm of life implies the full involvement of a person in its whirlpool, which is why so many people desperately lack rest. How to overcome the arisen drowsiness? A cup of aromatic coffee often helps to disperse drowsiness and turn on the active mode. But this method does not always work. Therefore, many choose an alternative - a drug called "Caffeine". Instructions for use characterizes it as a psychostimulant drug, the effectiveness of which is associated with the alkaloid contained in it, produced from tea leaves (2% caffeine), coffee beans (1-2 percent) and kola nuts.

"Caffeine-sodium benzoate", which can be found in pharmacies, is a synthetic drug derived from these compounds.

Pharmacological properties (application)

A derivative of methylxanthine - caffeine - has a psychostimulating and analeptic effect on the body. Its main property is the ability to improve motor activity, stimulate positive reflexes and various excitation processes occurring in the cerebral cortex. Due to this effect on the body, mental and physical activity increases, drowsiness disappears, and the feeling of fatigue decreases.

Caffeine can also increase blood pressure, but this happens more often in states of shock or collapse. In small doses, caffeine provides a stimulating effect, in large doses, depression of the nervous system often occurs. What other effect does caffeine have? Instructions for use warns of an increase and deepening of breathing when taking the drug, constriction of cerebral vessels and a decrease in oxygen pressure in it. With arterial hypotension, caffeine often normalizes blood pressure. Also known is the antispasmodic effect of the alkaloid, exerted on smooth muscles, and stimulating - on the striated. Under the influence of caffeine, the secretory activity of the stomach increases and the basal metabolism increases (increase in glycogenolysis, acceleration of lipolysis). A moderate diuretic effect is also a consequence of the use of caffeine.

"Caffeine": indications for use

The drug is prescribed for diseases accompanied by a depressed state of the central nervous system, for disorders in the work of the cardiovascular and respiratory systems (including poisoning with drugs, alcohol and toxins as a result of an infectious process), asphyxia, asthenia, enuresis (including in children), migraine, to relieve spasms of cerebral vessels. In ophthalmology, caffeine is used after eye surgery with a decrease in tone and retinal detachment.

This medicine is also indicated for decreased mental and physical performance, drowsiness, to restore the optimal level of activity. A steady trend in recent years has been the use of this drug as a catalyst for the process of losing weight. At the same time, the obligatory conditions are the exact observance of the dosage, doctor's recommendations and physical activity. In cosmetology, a mixture of "Caffeine-sodium benzoate" and "Capsicam" has proven itself as an effective anti-cellulite wrap.

Release form

"Caffeine-benzoate sodium" (containing up to 40% caffeine) is available as a solution for injection, tablets and powder (capsules).

Methods of application and dosage

How to take "Caffeine"? Tablets, the instructions for use of which advise to use them orally no more than 2-3 times a day, are prescribed for adults in a single dose of 100-200 mg (no more than 0.4 g) and daily - no more than one gram, for children - 25-100 mg. Ampoules with caffeine (1 ml) are intended for subcutaneous and subconjunctival administration.

Children are injected subcutaneously with a ten percent solution of caffeine, 0.25-1 ml. In ophthalmology, a 10% solution of caffeine in ampoules is also used: the drug is dripped under the conjunctiva no more than 0.3 ml once a day. Dosage, duration of treatment are prescribed by the doctor and depend on the patient's condition, as well as the nature of the disease. "Caffeine-sodium benzoate" should not be taken before bed.

Contraindications

Psychostimulant "Caffeine-benzoate" instructions for use do not recommend prescribing to people with arterial hypertension, irritability, sleep disorders (insomnia), suffering from atherosclerosis, tachycardia, epilepsy, convulsions, increased intraocular pressure (glaucoma). The drug is also contraindicated in children under 12 years of age and people of senile age. Anti-cellulite masks and should not be applied to the affected areas of the skin.

Side effects

While taking a drug containing caffeine, the instructions for use advise paying attention to possible negative reactions of the body: from the side of the central nervous system - anxiety, agitation, tremor, headache, anxiety, convulsions, dizziness, increased muscle tone, increased reflexes, insomnia, tachypnea . With a sharp withdrawal of the drug, lethargy, drowsiness, fatigue, increased inhibition of the CNS reaction may occur.

From the side of the CCC, arrhythmia, tachycardia, increased blood pressure are possible. From the gastrointestinal tract - nausea, exacerbation of peptic ulcer, vomiting, colic. With prolonged use, addiction is possible, dependence on the drug due to the formation of new adenosine receptors in the brain cells.

Overdose

What symptoms can excess caffeine cause? Instructions for use warns in such cases about increased severity of side effects: anxiety, confusion, mental and motor agitation, tremor or muscle twitching, epileptic seizures; dehydration, tachycardia, arrhythmia, headache, tinnitus, hyperthermia, frequent urination, nausea and vomiting.

The same conditions can occur after taking 300-600 mg (4 cups) of coffee per day, especially when combined with taking Caffeine-Sodium Benzoate tablets.

special instructions

During pregnancy and during the period of feeding the baby, caffeine intake is carried out in cases of emergency and under the supervision of a doctor! Abuse of the drug and drink threatens with possible spontaneous abortion, intrauterine growth retardation, inhibition or disturbances in the development of the skeleton, arrhythmia in the fetus. In the lactation period, caffeine penetrates into breast milk and, accumulating, threatens insomnia in the crumbs and its hyperactivity.

"Caffeine": instructions for use, price, storage conditions and expiration date

It is necessary to store the drug away from children, in a place inaccessible to them, at temperatures up to 25 degrees, no more than 5 years.

The cost of tablets "Caffeine-sodium benzoate" (6 pieces) in pharmacies today is approximately 32-40 rubles, a package of 10 ampoules (1 ml) of a 20% solution is sold for 40-64 rubles.

Analogues

In addition to tablets produced in blisters of 6 or 10 pieces, as well as an injection solution in ampoules, in pharmacies you can find drugs with various combinations of substances, which also include caffeine. What other medicines containing caffeine are emitted, instructions for the use of medicines? Analogues reviews of experts call the following: "Askofen" (40 mg) and "Cofitsil Plus" (50 mg of the substance in question), "Migrenol" and "Solpadein Fast" - 65 mg each, "Aquacitramon" (45 mg), and also "Citramon "And the usual" Solpadein "- 30 mg each. Of the drinks containing this common psychostimulant, reviews on the forums mention coffee, tea, hot chocolate and soda (cola). The double concentration of caffeine is distinguished by the Liquid Chestnut weight loss product, which includes guaranine (an analogue of caffeine and theine).

In this medical article, you can get acquainted with the drug Caffeine. The instructions for use will explain in which cases you can take a solution or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Caffeine, from which you can find out if the medicine helped in the treatment of low blood pressure (hypotension), spasms and drowsiness in adults and children, for which it is also prescribed. The instructions list analogues of Caffeine, drug prices in pharmacies, as well as its use during pregnancy.

The drug that stimulates mental activity is caffeine. Instructions for use informs that a solution for subcutaneous administration in ampoules, tablets of 100 mg sodium benzoate increase mental and physical performance.

Release form and composition

Caffeine comes in the form of:

Solution for subcutaneous administration: transparent, colorless or slightly colored (in ampoules of 2 ml, 5 ampoules in blister packs, 2 packs in a carton box; 5 or 10 ampoules in a carton box with partitions or bars).

The composition of 1 ml of the solution includes: active substance - caffeine-sodium benzoate 100 or 200 mg and auxiliary components: sodium hydroxide solution 0.1M - up to pH 6.8-8.5, water for injection - up to 1 ml.

Tablets for oral administration. The composition of 1 tablet of Caffeine-Sodium Benzoate may include 100 mg or 200 mg of caffeine.

pharmachologic effect

Caffeine sodium benzoate is a drug that helps reduce drowsiness and fatigue, has a stimulating effect on a person's mental activity, as well as on his mental and physical performance.

Caffeine is known for its stimulating properties aimed at the performance of the respiratory and vasomotor centers, the activation of cardiac activity, as well as the expansion of the blood vessels of the muscles, brain, heart, kidneys and vasoconstriction of the abdominal organs.

In premature babies, this drug reduces the partial pressure of carbon dioxide, eliminates periodic breathing and increases the volume of ventilation without affecting the heart rate.

Indications for use

What helps caffeine? Tablets are shown for use:

decrease in working capacity (physical and mental);
drowsiness;
disorders that occur with depression of nervous activity, the work of the cardiovascular and respiratory systems (including an overdose of opioid analgesics and diseases of an infectious nature);
spasms of cerebral vessels.

Instructions for use

Caffeine tablets for adults are prescribed 50-100 mg 2-3 times a day, regardless of food intake. The dose of the drug for children is 30-75 mg 2-3 times a day.

In ampoules Caffeine is intended for subcutaneous administration. The permissible single dose of the drug is 100-200 mg, the maximum daily dose is 600 mg. Children over the age of 12 are recommended to administer 25-100 mg of solution 2-3 times a day.

In ophthalmology, Caffeine Sodium Benzoate is also used in ampoules - the solution is injected into the area under the conjunctiva, 0.3 ml 1 time per day. The frequency of administration of the drug is prescribed and adjusted by the attending physician and depends on the intraocular pressure and the depth of the anterior eye chamber.

To prepare an anti-cellulite mixture for wrapping, mix 4 ampoules of Caffeine, Kapsikam ointment (the size of 2 peas) and a baby cream (4 peas). The resulting substance should be applied to problem areas and covered with cling film. You need to keep the application for 3 hours. During and for two hours after the wrap, it is not recommended to eat or drink any liquids. The course is 10 procedures.

For weight loss

Caffeine is often used for weight loss. This is due to a decrease in appetite and an increase in physical endurance when using the drug. Some nutritionists point to the ability of caffeine to burn an additional 5 kg of weight per month against the backdrop of intense physical training. It is worth remembering that uncontrolled use of the drug can cause unwanted side effects.

See also: how to take an analogue to improve cerebral circulation.

Contraindications

Pregnancy and lactation.
Paroxysmal tachycardia.
Frequent ventricular extrasystole.
Glaucoma.
Epilepsy and tendency to convulsive seizures.
Increased excitability.
Elderly age.
Hypersensitivity to the components of the drug.
Arterial hypertension.
Sleep disorders.
Organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis).

Side effects

excitation;
nausea, vomiting;
arrhythmias;
with prolonged use, addiction is possible;
sleep disturbance;
anxiety;
tachycardia;
increase in blood pressure.

Children, during pregnancy and lactation

It is used with extreme caution during pregnancy and breastfeeding.

In childhood

Contraindicated for use in children under 12 years of age.

special instructions

During the use of Caffeine, it must be taken into account that the sudden cessation of therapy can lead to increased inhibition of the central nervous system in the form of drowsiness and depression. The impact on the central nervous system can be manifested both by excitation and inhibition of the higher nervous system.

drug interaction

When used together with acetylsalicylic acid, it is possible to increase its absorption rate, bioavailability and blood concentration.
With simultaneous use, Mexiletin reduces the clearance of caffeine and increases its plasma content by blocking the metabolism of the latter in the liver.
Terbinafine, Ketoconazole and moderately increase the concentration of caffeine in the blood.
Due to the activation of microsomal enzymes under the influence of Phenytoin, when taken together, the metabolism and excretion of caffeine are accelerated.
With the simultaneous use of estrogens, it is possible to increase and increase the duration of the action of caffeine due to inhibition of the CYP1A2 isoenzyme.
Methoxsalen slows down the excretion of caffeine with a possible stimulation of its effect and the appearance of a toxic effect.
When used together, it is possible to enhance the effects of antipyretic analgesics, Naproxen, Salicylamide.
When taken simultaneously, caffeine accelerates the absorption of ergotamine.
When used together with adenosine, a decrease in the increased number of heart contractions caused by the administration of Adenosine is not excluded; the drug also reduces vasodilation associated with the action of Adenosine.
When used together, the effects of hypnotics and anesthetics are reduced.

Analogues of the drug Caffeine

According to the structure, analogues are determined:

Caffeine-sodium benzoate.
Caffeine anhydrous.
Dia-Activad-N.

Holiday conditions and price

The average cost of Caffeine (tablets 100 mg No. 6) in Moscow is 29 rubles. Released without a prescription.

The drug Caffeine instructions for use prescribes to store out of the reach of children at temperatures up to 25 ° C. Shelf life - 5 years.

Gross formula

C 8 H 10 N 4 O 2

Pharmacological group of the substance Caffeine

Nosological classification (ICD-10)

CAS code

58-08-2

Characteristics of the substance Caffeine

Pharmacology

pharmachologic effect- analeptic, cardiotonic, psychostimulant.

It has a direct stimulating effect on the central nervous system: it regulates and enhances excitation processes in the cerebral cortex, respiratory and vasomotor centers, activates positive conditioned reflexes and motor activity. Stimulates mental activity, increases mental and physical performance, shortens reaction time. After taking it, cheerfulness appears, fatigue and drowsiness are temporarily eliminated or reduced. Causes quickening and deepening of breathing, especially against the background of depression of the respiratory center. Affects the cardiovascular system: increases strength and heart rate (especially in large doses), increases blood pressure during hypotension (does not change normal). Expands bronchi, biliary tract, blood vessels of skeletal muscles, heart, kidneys, narrows - abdominal organs (especially when they are dilated). Reduces platelet aggregation. It has a moderate diuretic effect, mainly due to a decrease in the reabsorption of electrolytes in the renal tubules. Stimulates the secretion of the stomach glands. Increases basal metabolism, enhances glycogenolysis, causing hyperglycemia.

Blocks central and peripheral adenosine receptors. Promotes the accumulation of cAMP and cGMP by inhibiting the activity of phosphodiesterases involved in their inactivation. It inhibits cAMP phosphodiesterase to a greater extent (not only in the central nervous system, but also in the heart, smooth muscle organs, adipose tissue, skeletal muscles). Stabilizes transmission in dopaminergic synapses (psychostimulating properties), beta-adrenergic synapses of the hypothalamus and medulla oblongata (increased tone of the vasomotor center), cholinergic synapses of the cortex (activation of cortical functions) and medulla oblongata (excitation of the respiratory center), noradrenergic synapses (increased physical activity, anorexia ).

Caffeine and its water-soluble salts are well absorbed in the intestine (including the colon). T 1/2 is about 5 hours, in some individuals - up to 10 hours. The main part is demethylated and oxidized. About 10% is excreted by the kidneys unchanged. In the body of full-term newborns and infants (1.5-2 months) it is eliminated more slowly (T 1/2 - from 80 to 26.3 hours, respectively).

The effect on higher nervous activity is largely dependent on the dose and type of the patient's nervous system. In small doses, the stimulating effect prevails, in large doses it is depressing. In older people, the effect on sleep is more pronounced: its onset slows down, total sleep time decreases, and the frequency of awakenings increases (possibly due to faster metabolism of catecholamines in the central nervous system). In premature infants, when periodic breathing is eliminated, caffeine reduces the partial pressure of carbon dioxide, the concentration of H + in the blood and simultaneously increases the volume of ventilation without changing the heart rate.

The use of the substance Caffeine

Diseases accompanied by depression of the central nervous system, functions of the cardiovascular and respiratory systems (including drug poisoning, infectious diseases), spasms of cerebral vessels (including migraine), decreased mental and physical performance, drowsiness, enuresis in children, respiratory disorders (periodic breathing, idiopathic apnea) in newborns (including premature babies).

Contraindications

Severe arterial hypertension, organic diseases of the cardiovascular system (including atherosclerosis), irritability, glaucoma, sleep disturbances, old age.

Side effects of caffeine

Anxiety, agitation, insomnia, tachycardia, arrhythmias, increased blood pressure, nausea, vomiting. With prolonged use, slight addiction is possible (a decrease in the effect of caffeine is associated with the formation of new adenosine receptors in brain cells). Sudden cessation of caffeine administration can lead to increased CNS inhibition with symptoms of fatigue, drowsiness and depression.

Interaction

Reduces the effect of sleeping pills and narcotic drugs, increases (improving bioavailability) - acetylsalicylic acid, paracetamol and other non-narcotic analgesics. Improves the absorption of ergotamine in the gastrointestinal tract.

Overdose

When abused, caffeine (more than 300 mg per day, i.e. four 150 ml cups of natural coffee) can cause anxiety, anxiety, tremor, headache, confusion, cardiac extrasystoles. In newborns (including premature babies), at a plasma concentration of 50 mg / ml, toxic effects are possible: anxiety, tachypnea, tachycardia, tremor, increased Moro reflex, and convulsions at higher concentrations.