It is better to inject injections in the morning or evening. Mexidol when it is better to inject in the morning or in the evening. Solution for intramuscular and intravenous administration

Being overweight is the most innocuous problem that ignoring your biological clock leads to. Sleep specialist Michael Breus, in his book Always on Time, explains how to create a daily schedule that will allow you to make the most efficient use of your own resources. The most important thing is to determine your chronotype, but there are a few things that will work for everyone. Today we will give answers to five pressing questions about health, as well as life hacks for communicating with doctors and pharmacists.

When is the best time to take medication?

The body's defenses are most active at night, when we are resting, and passive during the day, when we are awake. The body needs to recover after a hard day, and basically this process occurs in the first third of the night in the phase of deep sleep with slow waves.

Before going to bed, you can “help” the recovery work with medicines, then the body will cope with the disease better. The effect of the drugs will increase, so Dr. Breus recommends taking them at night.

How many hours do you need to sleep?

In 2015, researchers at the University of California, San Francisco and Carnegie Mellon University tracked the sleep of 164 adults over the course of a week using wrist monitors. Then the subjects were sent to the laboratory, where they were injected with nasal drops with rhinovirus and monitored their health for another five days. Those who slept less than six hours were significantly more likely to fall ill than those who slept seven hours. All other variables - gender, medication, BMI, psychological problems - were excluded.

Just one hour of sleep played a significant role.

During the day it is advised to sleep 10-15 minutes.

Breus advises all chronotypes to sleep at least seven hours a day, but no more than nine. Excessive sleep of an adult indicates that not everything is in order with health. Most often, such people suffer from depression or narcolepsy.

What time are the injections?

Some adults, like children, are afraid of injections. Studies have shown that the pain of the injection depends on the biorhythms, and any discomfort associated with this can be reduced. In 2014, scientists at the University of Haifa in Israel applied various pain stimuli with varying degrees of intensity - mechanical, cold and warm - to 48 male subjects to test pain tolerance in the morning, afternoon and evening.

It turned out that in the morning people can endure severe pain longer.

So if you are shaking from one kind of syringe, go for injections in the morning, when the sensitivity threshold is higher.

How to make vaccination more effective?

All chronotypes should be vaccinated against influenza in early October. This is the perfect time to protect yourself from disease. But there is one trick that will make the vaccine "work" at its maximum.

In 2011, researchers at Iowa State University, including Marian Kohut, professor of kinesiology, vaccinated a group of students against the H1N1 influenza virus, and then sent some of them out for a run or bike ride for 90 minutes immediately afterwards. The control group did not exercise. A month later, the subjects were checked for the amount of antibodies produced. The group with physical activity had twice as many of them as the control group. In other words, the body of "athletes" responded more effectively to this virus. Next time you get your flu shot, go for a run or walk in the park after your flu shot. This will double the effectiveness of the vaccine.

When to do a mammogram?

The main task of mammography is to detect a possible tumor. There are several points that increase the accuracy of the study. Doctors do not talk about this, but following the recommendations will help to detect the disease in time.

Many women do not know that caffeine increases the sensitivity of the breast and exacerbates the pain in the fibroid tumor. The Duke University study included 138 women with fibrocystic breast disease, of whom 113 were completely caffeine-free within a year. Of these, 69 reported a reduction or disappearance of chest pain. Avoid coffee, tea, or caffeinated soda for one to two days before your mammogram to make the procedure easier.

The accuracy of mammography also depends on the days of the cycle. According to a large-scale study by scientists from the Seattle Health Research Institute, it is best to schedule the procedure for the first week of the cycle (the first day is considered the first day of menstruation). An analysis of 387,218 mammograms of women aged 35 to 54 over eleven years showed that for 66.6% of women, 79.5% of positive results (when the tumor was detected) were obtained in the first week. At this time, the breast tissue is less dense: swelling due to fluid retention during premenstrual syndrome subsides, and the tumor is easier to notice.

To summarize: two days before the mammogram, do not drink caffeinated drinks, tea, and sign up for the procedure in the first week of the cycle. Then the study will be the most accurate.

Life hacks to help you communicate with doctors and pharmacists

• Sign up for an examination in the morning. The waiting time will be shorter, which will alleviate the annoyance, irritation and hunger if you need to donate blood on an empty stomach. The body is more constrained in the morning, the respiratory volume is reduced, so arthritis and asthma will make themselves felt. In this way, the doctor will be able to better assess your condition.
• Make an appointment for the operation in the morning. The effectiveness of anesthesia depends on biotime. Side effects from anesthesia are more likely during the daytime, according to Duke University Medical Center, which analyzed 90,000 surgeries at the university hospital from 2000 to 2004. Patients in the study also reported additional administrative problems during the daytime - long waiting times, paperwork - circumstances that skyrocketed blood pressure. Moreover, surgeons are less likely to make mistakes in the morning: unpleasant incidents occur much less during peak hours of activity - from 9.00 to 12.00. And failures are more likely to occur during periods of decline in activity - between 15.00 and 16.00. During the day, patients are also more likely to experience postoperative pain and nausea.
• Submit prescriptions for the preparation of drugs in the morning and pick up prepared drugs in the afternoon. The pharmacist will have enough time to prepare the medicines and not make a mistake due to haste.

Life hacks and answers to questions about health are prepared based on the materials of the book "Always on time". It is not yet on sale, and to find out when it will be published, subscribe to the notification: as soon as the book arrives from the printing house, you will immediately know about it. The first readers will be able to purchase it at a discount!

In the sports circle, the use of steroid drugs is quite popular and relevant. And even if you have made the final choice and decided to take this or that drug, there are still a number of problems that are important and need to be solved.

It is about the correct injection into the body. It's no secret that most of the courses somehow include injectable drugs. They, unlike oral (tablet) require special "care".

And today we will try to answer in detail the question of interest to everyone: “How to inject steroids correctly?”.

So, if we have decided on the drug, then we will move on to choosing the main tool of our work - syringe. The unwritten rule should be to buy a new syringe in the package, this is very important. Make sure the syringe is sterile. That is why immediately after unpacking it, you need to start the procedure. Otherwise, you risk exposing yourself to infection. The syringe should be no more than 5 cubes in volume - this is quite enough to make a high-quality injection. Before each new injection, you must use only a new syringe, even if you inject only yourself. Before administering the drug, you need to make sure that there is no excess air in the syringe. This is a standard procedure before the administration of all drugs. So, you need to inject steroids with a new 5cc syringe, which must be changed after each injection, while ensuring your own safety and cleanliness.

The next very important point is the definition of where is the best place to poke anabolic steroids - in the buttocks or biceps?

It all depends on where it is more convenient for you to put injections. There are two main places for such procedures:

• Upper buttock;

• Delta (biceps).

We offer you to clearly see where and how to inject steroids in the pictures above.

Please note that it is strictly forbidden to inject steroids into a vein! This can lead to death.

Many are tormented by another question: “When is it better to administer drugs - early in the morning or late in the evening? In most drug instructions, this item is not indicated for the reason that, in principle, it does not really matter. Much more important is what day you will give the injection and whether you have correctly determined your course schedule.

Some argue that in the case of an evening workout, steroids should be administered in the morning. But if you plan to train in the morning, then the drug must be “set” in the evening. This is about the male hormone testosterone. But everything is individual and in order to determine the time of administration of the drug specifically for you, you need to consult a specialist, as well as study the characteristics of your biological rhythms and the training process.

There is a general set of rules that must be observed:

• Wash hands with soap;
• Prepare everything necessary for the procedure - a needle, a preparation, cotton wool, alcohol;
• Remove the protective film (case) from the syringe;
• Insert the needle into the vial;
• It is necessary to turn the vial over so that the syringe can fill with liquid;
• It must be borne in mind that the amount of liquid should be slightly more than expected;
• Next, you need to release excess air from the syringe. To do this, you need to knock on it (when the needle is still in the vial) and, if necessary, return the excess liquid with air back to the ampoule;
• Do not touch the needle either to the body or to foreign objects before the procedure;
• It is necessary to wipe the injection site with alcohol or vodka (in extreme cases);
• Then it is necessary to insert the syringe at an angle of 90 degrees, inserting the needle deep into the muscle tissue;
• If blood appears during the injection, you need to remove the needle and choose another place where the injection will be made;
• If the blood does not appear, then you just need to slowly inject the medicine into the muscle;
• After the injection of the drug, you must immediately remove the needle and massage the injection site with a clean swab soaked in alcohol.

So, we figured out the main points associated with the introduction of the drug intramuscularly. You need to be aware that this is a very responsible process. It requires a serious approach and compliance with a number of rules.

B vitamins are responsible for the processes of hematopoiesis, the functioning of the musculoskeletal system and the normal functioning of nerve fibers in the human body. In order to make up for their shortage, Milgamma is used: intramuscularly or orally (Milgamma is not administered intravenously). Intramuscular administration of Milgamma allows you to quickly eliminate pain, since with this method of administering the drug, the necessary therapeutic concentrations are reached already 10-15 minutes after the manipulation.

Despite the harmlessness of the drug, there are some recommendations on how to inject Milgamma correctly. Therefore, before starting use, it is necessary to contact a qualified specialist of the Yusupov hospital, who will answer all the questions, the most frequent of which are: “How many times a year can you inject Milgamma?”, “What time of day is it better to inject Milgamma - when is it better to inject Milgamma: in the morning or in the evening?”, “Which syringe to inject Milgamma?”, “How often can Milgamma be injected intramuscularly?” etc.

Why inject Milgamma?

The described drug is used to treat a large number of syndromes and diseases of the musculoskeletal system and nervous system:

• plexopathies;
• neuralgia;
• paresis of the facial nerve;
• ganglionite;
• neuritis;
• shingles;
• neuropathy;
• retrobulbar neuritis;
• diabetic polyneuropathy;
• nocturnal convulsive muscle contraction;
• radiculopathy;
• muscular-tonic syndrome;
• alcoholic polyneuropathy;
• lumboischialgia;
• myalgia;
• herpesvirus infections that affect the joints;
• polyneuropathy.

It must be understood that Milgamma can only be used while taking other, more potent drugs, this must be taken into account before injecting Milgamma intramuscularly. The use of this vitamin solution helps to improve blood microcirculation, activate hematopoietic processes, stabilize the functions and conductive abilities of the nervous system.

In addition, Milgamma is an excellent general tonic, which is prescribed to persons with a lack of B vitamins.

Who should not use Milgamma?

The drug Milgamma is contraindicated in persons with high sensitivity to its constituent components, as well as those suffering from decompensated heart failure.

Benefits of Intravenous Milgamma

Both the oral form and the intramuscular solution have the same composition and mode of action. Intramuscular injections of the drug are used, most often, for patients with severe pain, because. due to the introduction of the drug directly into the muscle, a more accelerated effect is achieved.

Conducted pharmacological studies have shown that the maximum level of therapeutic concentration of the active ingredients of the drug Milgamma is observed already 15 minutes after intramuscular injection.

Milgamma, released in the form for oral administration, begins to exert its effect only half an hour after ingestion. In addition, for maintenance therapy, one injection every two to three days is sufficient, while taking tablets should be daily.

Considering the foregoing, we can conclude that the advantages of using Milgamma intramuscularly lie in the faster achievement of the effect, which is especially important for severe pain, since Milgamma injection is prescribed most often in these cases.

Milgamma (injections): how many days to inject Milgamma?

Before starting therapy with this drug, it is imperative to consult with a neuropathologist who will decide how often Milgamma injections can be given, when to inject - in the morning or in the evening and select the required dosage. For qualified advice, you can contact one of the leading centers in Moscow - the Yusupov Hospital.

The duration of the therapeutic course of Milgamma for persons with severe pain can be from five to ten days. Injections are given daily, the daily dosage is 2 ml. After the acute inflammatory process subsides and the intensity of pain decreases, Milgamma Compositum is administered orally. However, in some cases, the doctor may recommend continuing intramuscular administration of the drug, but not more than two to three times a week.

Milgamma (shots): how to inject the drug?

Milgamma injections are quite painful, so there are special rules for the procedure, the observance of which will significantly reduce the discomfort of the patient:

• for intramuscular injection of Milgamma, the thinnest needles should be used, since the oily consistency of the solution makes manipulation difficult;
• to reduce the risk of damage to the nerve bundles and blood vessels by the needle, it should be inserted into the muscle as deeply as possible. Therefore, the choice must be stopped on the longest needle;
• Slow and smooth pressure must be applied to the syringe plunger. The drug should be administered for about one and a half minutes, which will significantly reduce pain;
• after the injection, the patient is recommended to do a light massage at the injection site, due to which the solution will be more quickly distributed in the muscle tissue and the likelihood of hematomas will decrease;
• in the event of a lump in the injection area, you can make a warm compress or lotions based on magnesia.

Is it possible to inject Milgamma with oncology?

The opinion that Milgamma injections can be given for cancer is deeply wrong. This drug can only worsen the patient's condition. This is due to the fact that the main components of Milgamma are B vitamins, which can help accelerate the growth of malignant cells and significantly aggravate the problem.

In order to eliminate the pain caused by the development of a malignant neoplasm, the use of completely different drugs is prescribed.

The benefits of Milgamma for cancer patients are minimal, while the harm caused by the drug in this situation can be quite significant.

Is it possible to inject Milgamma during menstruation and pregnancy?

Milgamma can be used on any day of a woman's menstrual cycle without any effect on it.

Due to the fact that there is currently no sufficient information on the effect of Milgamma components on intrauterine development of the fetus, the drug is not prescribed to pregnant women.

Is it possible to inject Milgamma with endometriosis?

The drug Milgamma is often part of the treatment of endometriosis and is often used in gynecological practice. How much Milgamma can be injected with endometriosis and in what dosages - the gynecologist decides, in accordance with the severity of the disease and the individual characteristics of the patient.

Is it possible to inject Milgamma in the evening?

Many patients wonder what time of day it is better to inject Milgamma - morning or evening? Since the drug is inherently a vitamin complex, from a therapeutic point of view, it is more logical to give an injection in the morning, when the intensity of metabolic processes is higher. However, in cases where Milgamma is part of a complex treatment along with other drugs for intramuscular injection, the sequence of their administration is established by the attending physician.

special instructions

If Milgamma was accidentally administered intravenously, the patient should be under the supervision of a physician who will prescribe symptomatic therapy for adverse symptoms.

There are no data on how Milgamma's intake affects the ability to drive vehicles and work with precise mechanisms.

Reception of Milgamma should be prescribed only by a qualified specialist who is familiar with the characteristics of the patient's body, his diagnosis, and a history of diseases. He selects the required dosage and decides how much to inject Milgamma.

In the Yusupov hospital, you can get advice from a competent specialist who will tell you how often to inject Milgamma, and also prescribe a comprehensive examination to identify contraindications to the drug. Diagnostic studies are performed on modern high-precision equipment, which is equipped with the Yusupov hospital.

Bibliography

• ICD-10 (International Classification of Diseases)
• Yusupov hospital
• Badalyan L. O. Neuropathology. - M.: Enlightenment, 1982. - S.307-308.
• Bogolyubov, Medical rehabilitation (manual, in 3 volumes). // Moscow - Perm. - 1998.
• Popov S. N. Physical rehabilitation. 2005. - P.608.

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*The information on the site is for informational purposes only. All materials and prices posted on the site are not a public offer, determined by the provisions of Art. 437 of the Civil Code of the Russian Federation. For exact information, please contact the clinic staff or visit our clinic.

All these conditions are successfully stopped by the drug Mexidol. The question of when to inject Mexidol in the morning or in the evening worries many.

Brief description of the drug

Mexidol is prescribed by a neuropathologist or cardiologist to treat diseases of the brain, heart and nervous system.

It perfectly helps, both with mild vegetovascular disorders, and with serious pathologies:

• asthenic syndrome on the background of alcohol dependence;
• acute cerebrovascular accident;
• ischemic heart disease;
• stroke and heart attack;
• severe intoxication with neuroleptics;
• neurosis-like and psychosomatic disorders;
• oxygen starvation of tissues of different etiologies (hypoxia).

It is actively used during the recovery period after craniocerebral injuries and purulent inflammation of the abdominal organs. Approved for use by almost everyone, except for children (under 12 years old) and pregnant women. It is well tolerated, with the rare exception of individual intolerance to the components.

Mexidol is produced in tablets and injections, which allows it to be used in various ways - orally, intramuscularly, intravenously. At the same time, it can be administered by jet and drip, depending on the severity of the condition. Doctors are inclined to believe that it is better to inject Mexidol, for a more systemic and faster effect.

When is it better to inject Mexidol

The injection form of the drug is available as a concentrated solution in ampoules. 1 ml of the drug contains 50 mg of the active substance (ethylmethylhydroxypyridine succinate). There is no universal instruction for use. In each individual clinical case, an individual treatment regimen and course duration are selected:

• with mild vegetative disorders, an injection of Mexidol is given intramuscularly at a dosage of kg per day for 2-4 weeks;
• severe conditions associated with cerebral circulation dysfunction require drip or jet administration of the drug in an amount of mg 2-4 times a day

Most experts agree that Mexidol should be injected in the morning, that is, in the morning. There are good reasons for this recommendation. The drug has a tonic effect, it invigorates and activates the work of the cardiovascular system. If you inject before bed, it will be difficult to fall asleep. Therefore, with a single use, it is advisable to inject in the morning. If the treatment regimen involves dividing into several doses, then the evening procedure should be carried out a few hours before bedtime.

Mexidol is used exclusively as directed by a doctor, so the nuances over the time of injection are discussed individually.

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IMPORTANT. The information on the site is provided for reference purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

Is it necessary to do mexidol injections in the morning?

Hello. The attending physician prescribed mexidol injections. And she pointed out what must be done in the morning. The nurse has been busy since morning. What to do?

Hello. The instructions for Mexidol do not indicate any specific time of day for the administration of this drug.

I think that the recommendation of the attending physician to give injections in the morning is justified by the fact that patients often feel a surge of vigor after an injection of Mexidol. This can be explained by the fact that due to the antioxidant and antihypoxic action of mexidol, the activity of brain cells increases. Although this is more common in the elderly, it can also occur in young patients who are sensitive to the drug.

Based on this action of Mexidol, the use of Mexidol in the morning is really recommended. However, there are no strict guidelines for the time of day.

So, if you can't take shots in the morning, try to take them at lunchtime and at least don't take them in the evening. After all, it will not be entirely comfortable if you feel alert and active at night instead of going to bed.

Mexidol

The description is current as of 09/04/2014

• Latin name: Mexidolum
• ATX code: N07XX
• Active ingredient: Ethylmethylhydroxypyridine succinate (Aethylmethylhydroxypyridini succinas)
• Manufacturer: Ellara LLC, Armavir Biofactory, Moscow Endocrine Plant, Mir-Pharm, ZiO-Health, ALSI Pharma (Russia)

Compound

The composition of the drug in the form of a solution for injection includes ethylmethylhydroxypyridine succinate as an active substance (50 mg per 1 ml) and auxiliary components:

The composition of one Mexidol tablet includes 125 mg of the active substance ethylmethylhydroxypyridine succinate, as well as a number of auxiliary components:

• lactose monohydrate;
• sodium carboxymethylcellulose (sodium carmellose);
• magnesium stearate.

Each tablet is coated with a white or creamy white coating, consisting of:

• opadra II white (macrogol polyethylene glycol);
• polyvinyl alcohol;
• talc;
• titanium dioxide.

Release form

The drug Mexidol has two forms of release: in ampoules and in tablets.

Mexidol in ampoules is intended for infusions and intramuscular injections. The solution is available in colorless or light-protected glass ampoules, on which the breaking point is indicated in blue or white and with three marking rings, the top of which is yellow, the middle is white, the bottom is red.

Ampoules have a capacity of 2 or 5 ml and are packed in 5 pieces in blisters. The carton package is completed with 1 or 2 contour packs, as well as instructions for the medical use of the drug.

For hospitals, Mexidol solution is packed in 4, 10 or 20 blisters.

One tablet of the drug Mexidol has a mass of 125 mg and is intended for oral administration. Tablets are available in packs of 10 pieces in blister packs made of PVC film and aluminum foil, or 90 pieces in plastic jars made of food-grade plastic.

For hospitals of medical institutions, tablets are produced in plastic jars made of food-grade plastic, 450 or 900 pieces each.

Description of the drug in the form of a solution for injection

Mexidol in ampoules has the appearance of a clear liquid, which can be either colorless or slightly yellowish.

Description of the tablet form of Mexidol

Tablets are biconvex, round, film-coated, the color of which can vary from white to white with a slightly creamy tint.

pharmachologic effect

The drug Mexidol belongs to the pharmacological group of drugs that affect the nervous system.

In addition, it has a pronounced stress-protective effect (that is, it increases the body's resistance to stress), improves memory, has the ability to prevent or stop seizures, and also reduces the concentration of certain lipid fractions (in particular, low-density lipoprotein) in various tissues. and body fluids.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The pharmacological properties of Mexidol are due to the activity of ethylmethylhydroxypyridine succinate, which is part of it.

According to Wikipedia, this substance belongs to the category of drugs that prevent or slow down the processes of peroxidation of membrane lipids in cells.

Ethylmethylhydroxypyridine succinate belongs to the class of 3-hydroxypyridines and is a pyridine derivative of the general formula C5H4_nN(OH)n.

The substance has the form of colorless crystals, which are characterized by the ability to easily dissolve in ethanol and acetone, moderately soluble in water and limitedly in diethyl ether, benzene and naphtha.

The mechanism of action of ethylmethylhydroxypyridine succinate is determined by its antioxidant and membrane-protective properties.

Acting as an antioxidant, it slows down and suppresses oxidative chain reactions involving active free radicals represented by peroxide (RO2*), alkoxy (RO*) and alkyl (R*) forms of oxygen.

Due to this, against the background of the use of Mexidol:

• the activity of the antioxidant enzyme superoxide dismutase (SOD) increases;
• indicators of the ratio of proteins and lipids increase;
• the viscosity of cell membranes decreases and, accordingly, their fluidity increases.

The drug regulates and normalizes the activity of membrane-bound enzymes (in particular, the main enzyme of the cholinergic system of acetylcholinesterase, the enzyme of the lyase class of adenylate cyclase and calcium-independent PDE (phosphodiesterase)), as well as the activity of receptor complexes (for example, the GABA-benzodiazepine receptor complex).

• membrane-binding enzymes and receptor complexes have an increased ability to bind with sligands;
• normal indicators of the structural and functional organization of biological membranes are maintained;
• the processes of transport of neurotransmitters are normalized;
• indicators of synaptic transmission of neurotransmitters improve.

Tablets and injections of Mexidol can increase the body's resistance to the influence of various aggressive factors and pathological conditions associated with oxygen deficiency.

The drug effectively eliminates symptoms caused by oxygen starvation, shock, ischemia, circulatory disorders of the brain, as well as symptoms of general poisoning of the body with drugs (in particular, antipsychotics) or alcohol.

After a course of treatment with Mexidol (intravenously, intramuscularly or orally):

• the content of dopamine in the brain increases;
• the course of metabolic processes in the brain is normalized;
• cerebral blood supply is normalized;
• improves blood microcirculation;
• rheological parameters of blood improve;
• reduced platelet aggregation;
• the membranes of post-cellular blood structures (erythrocytes and platelets) are stabilized during hemolysis;
• indicators of the content of total cholesterol are reduced;
• indicators of LDL content are reduced;
• the severity of symptoms of pancreatogenic toxemia (general blood poisoning) decreases;
• the severity of the syndrome of endogenous intoxication due to acute pancreatitis decreases;
• the compensatory activity of aerobic glycolysis is enhanced;
• under conditions of oxygen starvation, the degree of inhibition of oxidative processes in the tricarboxylic acid cycle (Krebs cycle) decreases;
• the content of adenosine triphosphate (ATP) and creatine phosphoric acid (creatine phosphate) increases;
• synthesis of energy by cellular mitochondria is activated;
• cell membranes are stabilized;
• the course of metabolic processes in the areas of the myocardium affected by ischemia is normalized;
• the area of ​​the necrosis zone decreases;
• the electrical activity of the heart and its contractility are restored and improved (in patients with reversible type of cardiac dysfunction);
• blood flow increases in ischemic areas of the myocardium;
• the severity of the consequences of the reperfusion syndrome caused by acute coronary insufficiency decreases.

Treatment with Mexidol in / in or / m allows you to save ganglion cells, as well as nerve fibers of sensitive cells of the retina in patients with progressive forms of neuropathy caused by ischemic disease and hypoxia.

At the same time, patients have a significant increase in the functional activity of the retina and optic nerve, and visual acuity increases.

The anti-stress effect of treatment with Mexidol tablets is expressed as:

• normalization of behavior after stress;
• disappearance of symptoms of somatovegetative disorders;
• normalization of sleep and wake cycles;
• restoration (partial or complete) of impaired learning abilities;
• memory recovery;
• reducing the severity of dystrophic and morphological changes in various parts of the brain.

Mexidol is also a remedy that effectively eliminates the symptoms that occur during withdrawal conditions.

It removes the manifestations of intoxication caused by alcohol withdrawal (both neurological and neurotoxic), restores behavioral disorders, normalizes vegetative functions, removes or reduces the severity of cognitive impairments provoked by prolonged alcohol use or a sharp rejection of it.

Pharmacokinetics

After intramuscular injection, the active substance of Mexidol is determined in the blood plasma for another four hours. The time during which the maximum plasma concentration is reached is from 0.45 to 0.5 hours.

Mexidol is quickly absorbed from the bloodstream into various tissues and organs and is also quickly excreted from the body: the average retention time of ethylmethylhydroxypyridine succinate varies from 0.7 to 1.3 hours.

Biotransformation of ethylmethylhydroxypyridine succinate occurs in the liver. As a result, phosphate-3-hydroxypyridine, glucuron conjugates and other metabolic products are formed. Moreover, some of them are characterized by pharmacological activity.

The drug is excreted mainly in the urine and mainly in the glucuron-conjugated form. A small amount of it is displayed unchanged.

According to the annotation to Mexidol, there are no significant differences in the pharmacokinetic profiles of ethylmethylhydroxypyridine succinate when taking a single dose and undergoing course treatment.

After oral administration of the tablet, Mexidol ethylmethylhydroxypyridine succinate is rapidly absorbed, rapidly distributed in various tissues and organs, and rapidly excreted from the body.

After 4.9 to 5.2 hours after taking the tablet, its active substance is no longer detected in the patient's blood plasma.

After biotransformation in the liver, five metabolites are formed by conjugation with glucuronic acid. In particular, phosphate-3-hydroxypyridine, which then decomposes under the influence of alkaline phosphatase into 3-hydroxypyridine and phosphoric acid.

In addition, a pharmacologically active substance is formed in large quantities, which is determined in the patient's urine even hours after taking the drug, two glucuron conjugates and a substance that is excreted from the body in large quantities with urine.

The half-life of Mexidol after oral administration varies from 2 to 2.6 hours.

The substance is excreted mainly in the urine in the form of metabolites (this process is especially intense in the first four hours after ingestion), and only a small part of it is excreted unchanged.

Indicators of urinary excretion of the drug in unchanged form and in the form of metabolic products are characterized by individual variability.

Indications for the use of Mexidol

Indications for the use of Mexidol injections (intravenously or intramuscularly):

• acute circulatory disorders in the brain;
• traumatic brain injury (also injections of the drug are prescribed to relieve or reduce the severity of the effects of traumatic brain injury);
• slowly progressing insufficiency of cerebral blood supply (dyscirculatory encephalopathy);
• syndrome of neurocirculatory (vegetovascular) dystonia;
• mild forms of disorders of cognitive function of an atherosclerotic nature of origin;
• anxiety disorders that accompany neurotic and neurosis-like (pseudo-neurotic) conditions;
• acute myocardial infarction (the drug is prescribed from the first days in the form of droppers or intramuscular injections as part of a complex of therapeutic measures);
• open-angle glaucoma of the primary type (Mexidol in ampoules is intended for the treatment of the disease at various stages, while complex therapy is considered to be the most effective);
• alcohol withdrawal syndrome, characterized by a predominance of pseudoneurotic and vegetative-vascular disorders;
• symptoms of intoxication of the body with antipsychotic agents;
• purulent-inflammatory processes occurring in an acute form in the abdominal cavity (including necrotizing pancreatitis or peritonitis; the drug is prescribed as part of a complex of therapeutic measures).

Indications for the use of Mexidol tablets:

• the consequences of acute circulatory disorders in the brain, including the consequences of TIA (transient ischemic attack), as well as a prophylactic agent at the stage of decompensation of diseases caused by cerebrovascular accident;
• minor traumatic brain injuries and their consequences;
• non-inflammatory diseases of the brain (encephalopathy) of various origins (for example, dyscirculatory or post-traumatic);
• anxiety disorders that accompany neurotic and pseudoneurotic states;
• ischemic disease (as part of a complex of therapeutic measures);
• alcohol withdrawal syndrome, manifested mainly in the form of pseudoneurotic, vegetative-vascular and post-withdrawal disorders;
• symptoms of poisoning with antipsychotic drugs;
• asthenic syndrome.

Also, an indication for the use of the drug in tablet form is the presence of a symptom complex in the patient, due to the impact of stress factors on the body.

In addition, as a preventive measure, Mexidol is indicated for patients who have a high risk of developing somatic diseases due to exposure to extreme factors and stress.

The mechanism of action of Mexidol is determined by its antihypoxic, antioxidant and membrane-protective properties. Therefore, to the questions “What Mexidol tablets are from?” and “When is Mexidol solution effective?”, experts answer that the most appropriate and successful is the appointment of the drug for:

Contraindications for Mexidol

Contraindications to the appointment of the drug are:

• hypersensitivity to ethylmethylhydroxypyridine succinate or any of the auxiliary components;
• acute liver failure;
• acute renal failure.

Side effects of Mexidol

The drug is well tolerated and rarely provokes certain undesirable effects.

Side effects, which in some cases may occur after taking Mexidol in the form of a solution:

Side effects that are potentially possible after taking Mexidol tablets include:

Also, the drug sometimes increases or lowers blood pressure, provokes emotional reactivity, distal hyperhidrosis, impaired coordination and the process of falling asleep.

Instructions for use Mexidol: method and dosage

Mexidol injections, instructions for use. How to administer intramuscularly and intravenously

The drug in the form of a solution for injection is intended for intramuscular or intravenous administration (by jet or drip infusion). If Mexidol is prescribed for intravenous administration, the contents of the ampoule should be diluted in isotonic sodium chloride solution.

Jet infusion involves the introduction of a solution for five to seven minutes, the drip method is administered at a rate of forty to sixty drops per minute. In this case, the maximum allowable dose should not exceed 1200 mg per day.

Before injecting intramuscularly or injecting the drug intravenously, you should read the instructions. The optimal dosage of Mexidol in ampoules is selected individually in each case, depending on the patient's diagnosis and the nature of the course of his disease.

Dosing of Mexidol in the form of a solution

Acute circulatory disorders of the brain: from 200 to 500 mg by drip into a vein two to four times a day during the day.

Further, the drug should be administered intramuscularly. As indicated in the instructions, this method of treatment is the most effective. Intramuscularly, the solution is administered for two weeks, twice or once a day, at a dose of 200 to 250 mg.

Elimination of the consequences of traumatic brain injury: the drug is administered by drip at a dose of 200 to 500 mg. The frequency of injections is from 2 to 4, the duration of the course of treatment is from 10 to 15 days.

Slowly progressive insufficiency of cerebral blood supply at the stage of decompensation: the drug is administered by drip or jet method once or twice a day for two weeks.

The dose is selected individually and varies from 200 to 500 mg. Further treatment involves the appointment of intramuscular injections: over the next 14 days, the patient is administered from 100 to 250 mg of Mexidol per day.

As a prophylactic against dyscirculatory encephalopathy: the drug is prescribed for injection into the muscle, the daily dose is from 400 to 500 mg, the frequency of injections is 2, the duration of the therapeutic course is two weeks.

Mild cognitive impairment in elderly patients and anxiety disorders: the solution is injected into the muscle, the daily dose varies from 100 to 300 mg, the duration of the therapeutic course is from two weeks to one month.

Acute myocardial infarction (in combination with other therapeutic measures): the drug is injected into a muscle or vein for two weeks in combination with traditional measures that are taken to treat patients with myocardial infarction.

In the first five days of the therapeutic course, the drug is recommended to be administered intravenously by drip infusion, then you can switch to intramuscular injections (injections continue to be given for nine days).

With the infusion method of administration, Mexidol is diluted in an isotonic sodium chloride solution or in a 5% glucose solution. The recommended volume is from 100 to 150 ml, the infusion time can vary from half an hour to an hour and a half.

In cases where this is necessary, the introduction of a solution by drip is allowed (in this case, the duration of the infusion should be at least five minutes).

Both intravenously and intramuscularly, the drug should be administered three times a day with an interval of eight hours. The optimal dose is from 6 to 9 mg per day for every kilogram of the patient's body weight. Accordingly, a single dose is 2 or 3 mg per kilogram of body weight.

In this case, the maximum allowable daily dose should not exceed 800 mg, and a single dose.

Open-angle glaucoma (for various stages of the disease in combination with other therapeutic measures): the drug is administered intramuscularly for two weeks, the daily dose varies from 100 to 300 mg, the frequency of injections is from 1 to 3 during the day.

Alcohol withdrawal: method of administration - drip infusion or intramuscular injection, the daily dose varies from 200 to 500 mg, the frequency of injections is 2 or 3 per day. The duration of the therapeutic course is from 5 to 7 days.

Intoxication with antipsychotic drugs: route of administration - intravenously, daily dose - from 200 to 500 mg, duration of the therapeutic course - from one to two weeks.

Acute purulent inflammatory processes of the abdominal cavity: the drug is indicated for use both on the first day before surgery and on the first day after the operation. Method of administration - intravenous drip and intramuscularly.

The dose is selected depending on the severity and form of the disease, the extent of the lesion, the characteristics of the clinical picture. It varies from 300 (for mild necrotizing pancreatitis) to 800 mg (for extremely severe disease) per day.

Cancellation of the drug should be carried out gradually and only upon reaching a stable positive clinical and laboratory effect.

Mexidol tablets, instructions for use

Mexidol tablets are intended for oral administration. The daily dose varies from 375 to 750 mg, the multiplicity of doses is 3 (one or two tablets three times a day). The maximum allowable dose is mg per day, which corresponds to 6 tablets.

The duration of the course of treatment depends on the disease and the patient's response to the prescribed treatment. As a rule, it is from two weeks to one and a half months. In the case when the drug is prescribed to relieve the symptoms of alcohol withdrawal, the duration of the course is from five to seven days.

In this case, abrupt withdrawal of the drug is unacceptable: treatment is stopped gradually, reducing the dose within two to three days.

At the beginning of the course, the patient is prescribed to take one or two tablets per dose once or twice a day. The dose is gradually increased until a positive clinical effect is obtained (while it should not exceed 6 tablets per day).

The duration of the therapeutic course in patients diagnosed with coronary disease is from one and a half to two months. If necessary, according to the doctor's prescription, a second course can be prescribed. The optimal time for the appointment of a second course is autumn and spring.

Overdose

The instruction warns that a medicine such as Mexidol, if the recommended dose is exceeded, can provoke the development of drowsiness.

Interaction

The drug is compatible with all drugs that are used to treat somatic diseases.

When used simultaneously with benzodiazepine derivatives, antidepressant, neuroleptic, tranquilizing, anticonvulsant (for example, carbamazepine) and antiparkinsonian (levodopa) drugs enhances their effect on the body.

This allows you to significantly reduce the doses of the latter, as well as reduce the likelihood of development and severity of unwanted side effects (for which Mexidol is prescribed to certain categories of patients).

The drug reduces the severity of the toxic effects of ethanol.

Mexidol and Piracetam: compatibility

Piracetam as an active ingredient is part of the drug Nootropil, which is used to improve the cognitive (cognitive) processes of the brain.

The joint appointment of Nootropil and Mexidol allows to achieve better results in increasing mental abilities in children, recovering patients after suffering an ischemic stroke or coma, treating chronic alcoholism, psychoorganic syndrome (including in elderly patients with reduced memory, mood lability, behavioral disorders) etc..

However, it should be noted that, in contrast to nootropic drugs (and, in particular, Nootropil), Mexidol does not have an activating effect on the body, does not provoke sleep disturbances and increase convulsive activity.

In terms of its therapeutic efficacy, it is significantly superior to Piracetam.

Compatibility Mexidol and Actovegin

Mexidol and Actovegin have a similar mechanism of action, so they are often prescribed in combination with each other. However, since Actovegin is made from calf blood, it provokes certain side effects more often than Mexidol.

Actovegin at the molecular level accelerates the processes of utilization of oxygen and glucose, thereby increasing the body's resistance to hypoxia and contributing to an increase in energy metabolism.

Compatibility Cavinton and Mexidol

As an active component of Cavinton, Vinpocetine is used, which is synthesized from vincamine, an alkaloid of the perennial Periwinkle plant. The substance has the ability to dilate blood vessels, improve blood circulation in the brain, and has a pronounced antiaggregatory and antihypoxic effect.

In addition, Vinpocetine is able to influence the metabolic processes occurring in the brain tissues, and reduces the aggregation (or, in other words, adhesion) of platelets, thereby improving its rheological properties.

Terms of sale

The drug belongs to the category of prescription drugs.

Storage conditions

Mexidol should be stored in a dry, dark place and out of the reach of children at a temperature not exceeding 25°C.

Best before date

Mexidol tablets and solution are suitable for use within 3 years. After the period indicated on the package, it is forbidden to use them.

special instructions

Solution for intramuscular and intravenous administration

In patients with a predisposition to allergic reactions, with increased sensitivity to sulfites, as well as in people with bronchial asthma, severe hypersensitivity reactions may develop during treatment.

Tablets Mexidol

During the course of treatment with Mexidol tablets, special care should be taken when driving and performing work that is hazardous to health and life. This is due to the fact that the drug has the ability to slow down the speed of psychomotor reactions and reduce concentration.

Mexidol's analogs

For many patients, the question often arises: “How can I replace the drug prescribed by the doctor and are there cheaper analogues?”.

Mexidol's analogs in tablets:

Analogues of the drug in ampoules are:

Quite often, patients have a question: which of the analogues of the prescribed drug is better, cheaper, where there are fewer side effects, etc. Therefore, it is worth considering this topic in detail.

Which is better: Actovegin or Mexidol?

The drugs are used in similar fields of medicine. For this reason, in order to achieve a more pronounced clinical effect, patients are prescribed them in combination.

Which is better: Cavinton or Mexidol?

Both Cavinton and Mexidol are complementary drugs, so they are often prescribed in combination to eliminate the effects of circulatory disorders in the brain.

The main requirement in this case is that the drugs should not be mixed in one dropper or in one syringe.

Which is better: Mexidol or Mexicor?

Mexicor is a generic (synonymous) of Mexidol. Therefore, the drug is used in the same areas of medicine as Mexidol. It is available in the form of gelatin capsules, tablets and solution for injection.

Mexicor effectively relieves anxiety, relieves fears and improves mood, improves memory, attention, increases efficiency and learning abilities, eliminates the symptoms of alcohol intoxication and reduces the pathological consequences of a stroke.

The drug belongs to the group of metabolic cardiocytoprotectors. The mechanism of its action is due to the fusion in its composition of the antihypoxant succinate and the antioxidant emoxipin, which is characterized by a wide spectrum of action.

In combination with other therapeutic measures, Mexicor is indicated for the treatment of myocardial ischemia and ischemic stroke. It is also recommended to prescribe it in the treatment of mild and moderate cognitive disorders and to reduce the severity of symptoms of discirculatory encephalopathy.

Mexiprim and Mexidol - which is better?

Mexiprim is a German analogue of Mexidol. Its manufacturer is STADA Arzneimittel AG. The main difference between the drugs is the composition of the auxiliary components of the core and shell of the tablets. The mechanism of action and indications for use are similar.

Mexidol or Mildronate - which is better?

Mildronate belongs to a group of drugs that improve metabolism and energy supply of tissues. It is available in the form of gelatin capsules, solution for injection and syrup for oral administration.

The active substance of the drug is meldonium (trimethylhydrazinium propionate), which is similar in structure to gamma-butyrobetaine (a substance present in every cell of a living organism).

Mildronate is used as a vasodilator. In addition, the drug improves the supply of organs and tissues with oxygen, improves humoral and tissue immunity, and reduces blood pressure.

Mexidol and Mildronate, at the discretion of the doctor, may be prescribed as part of combination therapy for the treatment of patients with:

Synonyms

• film-coated tablets and solution for intravenous and intramuscular administration Medomexi;
• solution for intravenous and intramuscular administration Meksidant;
• film-coated tablets and solution for intravenous and intramuscular administration of Mexiprim;
• solution for injections and tablets Meksifin;
• solution for intravenous and intramuscular administration Neurox;
• solution for injections and tablets Mexipridor;
• solution for intravenous and intramuscular administration and capsules Mexicor.

Prescribing the drug Mexidol to children

The drug is not prescribed for children and adolescents due to insufficient knowledge of the effect of ethylmethylhydroxypyridine succinate on the children's body.

Mexidol and alcohol

Mexidol is a drug with a powerful antioxidant effect. For this reason, it is widely used in a wide variety of fields of medicine, including surgery, psychiatry, neurology, etc.

To the question "What is the medicine Mexidol for?" an experienced specialist will answer that the latter effectively restores the function of the neurological and psychological spheres and, in addition, contributes to the renewal and maintenance of the functional activity of liver cells.

Due to the ability of the drug to have a hepatoprotective and nootropic effect, the appointment of Mexidol is one of the most common methods of treating alcohol withdrawal syndrome, which develops against the background of intoxication of the body with ethyl alcohol.

It is believed that Mexidol and alcohol are compatible. Some are inclined to believe that the drug partly even neutralizes the effect of the latter. However, this opinion is erroneous, since the active substance of Mexidol, penetrating into the tissues of the brain and liver, only relieves the existing symptoms of intoxication and eliminates the pathology, but does not protect the cells.

That is, the drug does not prevent the occurrence of unwanted symptoms of alcohol intake, but only eliminates its consequences:

• reduces the severity of headache;
• reduces the severity of symptoms of intoxication;
• accelerates the processes of excretion from the liver of residues of toxic substances and fusel oils contained in alcohol.

However, Mexidol cannot protect against liver cirrhosis or irreversible mental disorders if a person continues to drink alcohol at the same doses.

Mexidol during pregnancy and lactation

Pregnancy and lactation are contraindications to the appointment of Mexidol. This is due to the fact that strictly controlled studies of the effect of the drug on pregnant and lactating women have not been conducted.

For each method of application there is a separate dosage form.

Characteristics of the drug

For the production of Actovegin, the blood of dairy calves is used, from which deproteinized hemoderivat is obtained by dialysis and ultrafiltration. It contains amino acids, macronutrients, microelements, fatty acids, oligopeptides and other important physiological components.

Having received a doctor's prescription for therapy with an ampoule form of the drug, many are wondering whether it is possible to inject Actovegin intramuscularly or whether an intravenous infusion is needed. The answer can be obtained both from a doctor or pharmacist, and by reading the leaflet to the medicine - the drug is used for intramuscular use.

Actovegin is produced in several dosage forms: injection solution, ointment, tablets, cream, infusion solution and gel. This allows each patient to choose the ideal remedy.

In particular, injections of Actovegin intramuscularly are carried out using an injection solution. It is a clear liquid that has a yellowish color or is completely colorless. The drug is sold in ampoules with a volume of 2, 5 and 10 ml. The active component in the solution is included in the amount of 40 mg per ml. Thus, 2 ml contains 80 mg of gemoderivate, 5 ml - 200 mg, and 10 ml - 400 mg. The excipients are water for injection and sodium chloride.

Medication indications

The drug has a complex mechanism of action, providing a variety of its pharmacological effects, therefore, it is used in the treatment of many diseases in various fields of medicine. Its purpose is justified, if necessary, to improve the nutrition of body tissues, increase their resistance to hypoxia, which ensures the minimum amount of damage to body cell structures in conditions of oxygen deficiency.

Actovegin according to the instructions for intramuscular injection is used for:

• abnormal dilation of cerebral vessels;
• damage to the retina;
• dyscirculatory encephalopathy;
• ischemia and oxygen starvation of organs;
• vascular atherosclerosis;
• ischemic strokes;
• vascular angiopathy;
• extensive burns of a chemical and thermal nature;
• cerebral insufficiency;
• wounds and bedsores;
• diabetic polyneuropathies;
• frostbite;
• craniocerebral injuries;
• radiation and radiation damage to the skin and mucous membranes.

How to apply

Depending on the severity of the course of the disease, intramuscular or infusion medication is prescribed. The decision on this, as well as on the dosage of the drug, is made by the doctor.

Instructions on how to administer injections intramuscularly:

• Before carrying out the manipulation, you should thoroughly wash your hands with soap and treat with an antiseptic;
• The ampoule should be slightly warmed in the hand before administration;
• Holding the ampoule vertically and having lightly tapped on it so that the entire solution is in the lower part, break off its tip along the line with a red dot;
• The medicine is drawn with a sterile syringe, then turned upside down and a drop of solution is released to make sure that all the air is out;
• Visually divide the buttock into 4 parts and insert the needle into the upper outer square, after treating the skin with a cotton swab with alcohol;
• Enter the drug slowly;
• After the injection, the injection site is clamped with cotton wool or a napkin moistened with alcohol.

In injections, according to the instructions for use, Actovegin is used at 2-5 milliliters per day. The introduction can be carried out from 1 to 3 times a day.

The attending physician, based on the presence of indications, the severity of the course of the disease and the effectiveness of the treatment, can change the recommended doses in one direction or another. If it is necessary to administer the drug in doses exceeding 5 ml, it is recommended to use Actovegin intravenously.

The following doses of the drug are usually prescribed:

• In case of circulatory insufficiency of the brain, 5 ml of the drug is used for 14 days. Next, a tablet form is prescribed to support the effect;
• To speed up the process of tissue regeneration in wounds, frostbite and other damage to the epidermis, daily injections of 5 ml of Actovegin solution are indicated. Additionally, local forms of the drug are used - ointment, cream or gel.

Intramuscular administration is used for mild to moderate disease, while in more complex cases, infusion into a vein is required.

Precautionary measures

To ensure maximum efficiency and safety in the treatment with Actovegin in injections, it is necessary to follow the rules for its use.

Prior to the start of full-fledged therapy, the presence of individual intolerance should be determined. For this, 2 ml of the drug is injected intramuscularly for 1-2 minutes. Long-term administration allows you to observe the body's response to the drug and, with the development of anaphylaxis, you can stop the injection in time and start resuscitation of the patient.

From the above, the following admission rule follows - injections should be given in a medical institution, where, if necessary, emergency care can be obtained. If home treatment is nevertheless assumed, then at least the first dose should be administered in a hospital under the supervision of medical staff.

Intramuscularly, Actovegin is allowed to be administered at a dose not exceeding 5 ml, since the solution is hypertonic and can provoke a sharp jump in blood pressure.

It is important to create the most sterile conditions when administering the drug. An open ampoule should be used immediately, as there are no preservatives in the medicine that would provide longer storage. Therefore, the drug should be purchased in ampoules of the volume that needs to be injected at a time. After all, storage of an opened ampoule is prohibited.

Actovegin should be stored in the refrigerator, therefore, before use, the ampoule should be slightly warmed in the hands to ensure a more comfortable administration.

A solution with a visible precipitate or cloudy should not be used. The contents of the ampoule should have a yellowish color and transparency.

It is allowed to include Actovegin in complex treatment regimens for diseases, since no negative interaction reactions with other drugs have been established. It should be borne in mind that mixing it with other drugs in the same vial or syringe is strictly prohibited. The exception is solutions of sodium chloride and glucose, which are recommended for the preparation of infusion solutions. It is also forbidden to drink alcohol during treatment with the drug.

Side effects

Actovegin is well tolerated. The most frequent negative effect during its treatment are allergic reactions, including angioedema. Much less common are:

• redness or pallor of the skin;
• dizziness;
• chest pain;
• indigestion;
• quickening and difficulty breathing;
• general weakness;
• increased blood pressure;
• pain in muscles and joints;
• increased heart rate;
• fever;
• paresthesia;
• bouts of suffocation.

If any adverse reactions of the body to the use of the drug appear, Actovegin therapy should be discontinued and symptomatic treatment should be prescribed.

When using Actovegin injections intramuscularly, it must be borne in mind that this is a rather unpleasant and painful procedure. Therefore, its intravenous drip administration is preferable along with a solution of glucose or sodium chloride.

Contraindications

Actovegin has a high safety profile, which allows it to be used in a wide range of patients. However, there are exceptions. Injections of Actovegin intramuscularly are prohibited when:

• hypersensitivity to the components of the remedy;
• heart failure;
• violations of the outflow of urine;
• pulmonary edema;
• kidney diseases.

The use of the drug in special groups of patients

According to the instructions, the drug should not be prescribed in pediatrics due to the lack of a sufficient number of relevant studies. But in practice, many doctors use Actovegin to treat infants and children.

Intramuscular injections of the drug are practically not used in this category of patients due to the painfulness of the procedure. An exception are infants with the consequences of intrauterine hypoxia. But such injections are administered only in a hospital under constant medical supervision.

Pregnant women Actovegin is prescribed with caution, after assessing the possible consequences for the fetus. If it is necessary to administer the drug to such patients, preference is given to intravenous administration at the beginning of treatment with a further transition, when the condition improves, to intramuscular administration or taking tablets.

Indications for the appointment are: the threat of abortion, feto-placental insufficiency, placental abruption, Rh conflict, slowing down weight gain by the fetus or its low physical activity.

The use of the drug during lactation is also allowed, but only if its therapeutic effect on the mother's body exceeds the potential risk to the baby.

In geriatrics, the drug is used quite often. At the same time, judging by the reviews, it is in the elderly and senile age that the positive effect of Actovegin manifests itself best.

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IMPORTANT. The information on the site is provided for reference purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

All about Actovegin

All about the unique drug - actovegin

Pages

Actovegin - injections. Video. Instructions for injections

So why is an injection sometimes better than a pill?

The injection has a sister - this is a dropper, which is used when you need to inject a lot of medication and it should be administered only gradually.

With the help of a syringe, a solution is drawn from the ampoule (in order to avoid air ingress, it is necessary to release a drop of the solution, holding the syringe with the needle up).

Naturally, everything must be sterile ( here you can see video).

Or: five ml of the solution of the drug in / in - between therapy sessions.

Therefore, in such a situation, treatment with Actovegin is suspended and antihistamine (and, if necessary, corticosteroid) treatment is carried out.

Actovegin injections intramuscularly: inject slowly, no more than 5 ml (because this drug is hypertonic).

Injections can be done both in the morning and in the evening.

For children - it is highly undesirable, but in practice (in exceptional cases) Actovegin injections are given. In this case, the doctor evaluates all risks.

After opening the vial or ampoule, the Actovegin solution cannot be stored and then reused for injections: this will not only have no effect, but is simply dangerous to health.

With frequent use of Actovegin injections in patient therapy, it is necessary to check the electrolyte composition of the serum (K, Na, Ca, Cl, Mg.), As well as the water balance of the patient's body.

Treatment with Actovegin can be carried out only after consulting a doctor.-specialist and only after examining the patient. Neither self-treatment nor consultations given in absentia are recommended, tk. this can lead to complications.

Nevertheless, you can read reviews about Actovegin injections.

Actovegin also comes in the form of tablets, gel, ointment.

Keep ampoules should be in a dark place at room temperature (not higher than 25 ° C), in a package, out of the reach of children.

You may be interested in general instructions for the use of Actovegin, compatibility of Actovegin with other medicines, reviews of Actovegin by our readers, the price and manufacturers of the drug (and also its analogue Solcoseryl), the use of Actovegin in sports and in veterinary medicine (for the treatment of our pets).

You will find answers to these and many other questions on our website.

What time of day is best to inject Actovegin

Development of a child with MR (completed).

Thanks for the ideas, we'll implement it right now 🙂

Well, actually, everything is simple, he will need chirping when others around him will not understand him without chirping;) Ie. any information being studied should be applied in everyday life: “Go get me 2 + 2 pencils. find an object with the letter A. make a “cake” from the letters and get a piece. "and other garbage in the current daily life.

Before pregnancy, I never had problems with veins.

Before pregnancy, I never had problems with veins, I always had smooth and slender legs. And as soon as I got pregnant, it immediately became difficult to walk in heels, although my stomach was not yet visible. Further - worse. The legs began to swell, pouring lead, hurt at night. At first, the gynecologist said that this was normal for the expectant mother, because the load increased, but when my vascular network began to crawl out, it became clear that the matter was serious. Then I specifically asked the doctor about how.

Harm of pills to the fetus. Barinvakti's blog on 7ya.ru

Hello, I’m very worried, I live abroad, I have 5.5 weeks, severe cramps, the doctor said there was a threat of miscarriage, and they prescribed me 3 progesterone injections, progesterone suppositories and spasmalgon (2 tablets 3 times a day). In almost 2 days I received 3 injections of progesterone. After the third shot of progesterone, I fainted and my cramping pains got much worse. I have questions: could there be an overdose of progesterone? What causes spasms to hurt? On ultrasound, the doctor said that the fetus was well attached.

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Wrinkle cream, Botox or hyaluronic acid injections

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My daughter's birthday.

And flew. 4:30 They shake me by the leg, spread their arms with the word "Everything." I don't understand anything yet, because I'm dying to sleep after a sleepless night of wallpapering. Somehow I wake up. Alenka explains to me that the mucus plug has finally come off and she is having contractions. In general, the fact that the cork has finally departed is a harbinger, but it can still calmly take a few days before the birth. Yes, and contractions may well be trial (by the way, we have already been sitting with such trials in the country for an hour since.

For those who have missing apples.

It is very strange, but for some reason, none of my friends know that you can make a wonderful marshmallow thing from apples. Which is incredibly pleasant to chew in winter and remember about summer and childhood :)) For me, this is exactly the taste of childhood. My grandmother always prepared this delicacy for the winter. In general, if you have formed inedible padanki or just extra apples, then I recommend making marshmallow. The cooking process is simple to obscene. Peel the apples from the skin and core, cut into pieces and.

Just pour mashed potatoes on parchment and smooth with a spatula?

And then what thickness should this puree be initially? :)))))

I need to do this ASAP!!!

Israeli cosmetics Lamerel - an alternative to injections?.

Good day! I tried the other day a new cosmetics Lamerel from Israel - a cream with a lifting effect. I was pleasantly surprised - the effect is quick and pleasant (the oval of the face somehow tightened up, the color refreshed, the skin seemed to be from a vacation). Here I sit, racking my brains - what to do when it runs out - where can I buy Lamerel cosmetics in St. Petersburg? Fly back to Eilat for her? Write, who knows what and who else has tried this cosmetics?

If necessary, I'll poke. Vaccination (vaccinations) | How vaccinations are made

Post-vaccination reactions occur much more often, but they do not cause harm to health and, as a rule, do not require treatment. These include: An increase in temperature up to ° C in the first three days after vaccination. In this case, suppositories, tablets or syrup with paracetamol or ibuprofen help well. Attention! It is not recommended to use aspirin to lower the temperature! Also, you can not take this drug within a month after vaccination against chickenpox - this threatens with severe liver damage. In the case of the use of live vaccines, on the 7-14th day after vaccination, the development of a “disease in miniature” is possible (a rash appears, the joint swells.

Nutrition of children with pathological regurgitation syndrome.

Almost all new mothers are worried that their babies spit up after feeding. This is usually caused by aerophagia (air entering the esophagus during sucking). This is completely normal for babies.

Cesarean section: recover without loss! C-section

Recovery after caesarean section

Drugs for placental insufficiency. Vitamins.

Based on a comprehensive examination, a conclusion is made not only about the fact of the presence or absence of placental insufficiency, but also about the severity of such a violation. The tactics of conducting pregnancy with different degrees of severity of placental insufficiency is different. Prevention and treatment Currently, unfortunately, it is not possible to completely rid a pregnant woman of placental insufficiency that has arisen by any therapeutic effects. The applied means of therapy can only contribute to the stabilization of the existing pathological process and the maintenance of compensatory-adaptive mechanisms at a level that allows to ensure the continuation of pregnancy until the optimal term of delivery. Therefore, it is very important to carry out prophylaxis in women with risk factors for the development of placenta.

Actovegin increases the resistance of the brain and fetal tissues to hypoxia, activates metabolism, increases glucose consumption, and stimulates the renewal of fetal cells. In addition, the drug enhances blood circulation in the mother-placenta-fetus system, contributes to a better tolerance of the birth act by the fetus. Treatment with Actovegin has a pronounced effect on the condition of the fetus. This is reflected in improved blood flow and improved fetal growth, which reduces the frequency of forced early delivery. The drug is obtained from the blood of calves, has a minimum of side effects, a rather rare occurrence of allergic reactions has been noted. Contraindications to the use of the drug is heart failure.

Mom gives injections - help is needed. We need your experience and knowledge.

Who has experience in this matter? I need your help, otherwise my brain will boil now 🙁 We prescribed a course of treatment for the child, prescribed a bunch of medicines, incl. you need to give injections: 1. Cerebrolysin 1.0 ml intramuscularly 2. Actovegin 2.0 ml intramuscularly 3. Neuromidin 5 mg, 0.5 ml intramuscularly to myself. I am terribly afraid, while in my life I have never given injections myself. I have experience only in breeding Cortexin injections and, accordingly, I saw where to inject and how to inject. Those. With.

To mothers of restless children: PEP - myths and reality.

It is possible to minimize the time of mother's "lack of sleep" with the help of the rational organization of joint sleep and night feedings. Babies often sleep better next to their mothers. Motion sickness can also be replaced by applying to the chest before going to bed. When I learned that it was “possible” to do this, the time of motion sickness was significantly reduced. Often children wake up after sleep in a bad mood, you can also offer a breast, and the world will delight the baby again! Secondly, this is the assignment to the pathological of a number of adaptive, passing phenomena from the nervous system of the newborn (for example, shuddering or throwing up arms and legs, trembling of the chin with strong crying or.

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Actovegin - instructions for use (injections, tablets, ointment, gel, cream). Why is Actovegin prescribed?

Varieties, names, composition and forms of release

Actovegin is currently available in the following dosage forms (which are also sometimes called varieties):

• Gel for external use;
• Ointment for external use;
• Cream for external use;
• Solution for infusions ("droppers") on dextrose in 250 ml bottles;
• Solution for infusion in 0.9% sodium chloride (in saline) in 250 ml bottles;
• Solution for injection in ampoules of 2 ml, 5 ml and 10 ml;
• Tablets for oral administration.

Gel, cream, ointment and Actovegin tablets do not have any other everyday simplified name. But forms for injection in everyday life are often called simplified names. So, the injection solution is often called "Actovegin ampoules", "Actovegin injections", as well as "Actovegin 5", "Actovegin 10". In the names "Actovegin 5" and "Actovegin 10" the numbers mean the number of milliliters in an ampoule with a solution ready for administration.

• Gel Actovegin - contains 20 ml of gemoderivate (0.8 g in dried form) in 100 ml of gel, which corresponds to 20% concentration of the active ingredient.
• Ointment and cream Actovegin - contain 5 ml of gemoderivate (0.2 g in dried form) in 100 ml of ointment or cream, which corresponds to 5% concentration of the active ingredient.
• Solution for infusion in dextrose - contains 25 ml of hemoderivat (1 g in dried form) per 250 ml of a ready-to-use solution, which corresponds to an active ingredient concentration of 4 mg / ml or 10%.
• Solution for infusion in 0.9% sodium chloride - contains 25 ml (1 g dried) or 50 ml (2 g dried) hemoderivat per 250 ml ready-to-use solution, which corresponds to an active ingredient concentration of 4 mg / ml ( 10%) or 8 mg/ml (20%).
• Solution for injection - contains 40 mg of dry hemoderivat per 1 ml (40 mg / ml). The solution is available in ampoules of 2 ml, 5 ml and 10 ml. Accordingly, ampoules with 2 ml of solution contain 80 mg of the active ingredient, with 5 ml of solution - 200 mg and with 10 ml of solution - 400 mg.
• Tablets for oral administration - contain 200 mg of dry hemoderivate.

All dosage forms of Actovegin (ointment, cream, gel, solutions for infusions, solutions for injections and tablets) are ready to use and do not require any preparation before use. This means that the ointment, gel or cream can be applied immediately after opening the package, the tablets can be taken without preparation. Solutions for infusion are administered intravenously (“dropper”) without prior dilution and preparation, simply by placing a bottle in the system. And injection solutions are also administered intramuscularly, intravenously or intra-arterially without preliminary dilution, simply by choosing an ampoule with the required amount of milliliters.

• Mountain wax glycolate;
• Titanium dioxide;
• Diethyl phthalate;
• Dried gum arabic;
• Macrogol 6000;
• Microcrystalline cellulose;
• Povidone K90 and K30;
• Sucrose;
• magnesium stearate;
• Talc;
• Dye quinoline yellow varnish aluminum (E104);
• Hypromellose phthalate.

The composition of the auxiliary components of the gel, ointment and cream Actovegin is shown in the table below:

Cream, ointment and gel Actovegin are available in aluminum tubes of 20 g, 30 g, 50 g and 100 g. The cream and ointment are a homogeneous white mass. Gel Actovegin is a transparent yellowish or colorless homogeneous mass.

The volume of Actovegin ampoules in ml

Actovegin solution in ampoules is intended for intravenous, intra-arterial and intramuscular injections. The solution in ampoules is ready for use, so to make an injection, you just need to open the ampoule and draw the medicine into the syringe.

Therapeutic action

Actovegin is a universal stimulant of metabolism, which leads to a significant improvement in tissue nutrition and the utilization of glucose from the blood for the needs of the cells of all organs. In addition, Actovegin increases the resistance of cells of all organs and tissues to hypoxia, as a result of which, even under conditions of oxygen starvation, damage to cellular structures is minimally expressed. The general, total effect of Actovegin is to increase the production of energy molecules (ATP) necessary for the flow of all vital processes in the cells of any organ.

• The healing of any tissue damage (wounds, incisions, cuts, abrasions, burns, ulcers, etc.) and the restoration of their normal structure are accelerated. That is, under the action of Actovegin, any wounds heal easier and faster, and the scar is formed small and inconspicuous.
• The process of tissue respiration is activated, which leads to a more complete and rational use of oxygen delivered with blood to the cells of all organs and tissues. Due to a more complete use of oxygen, the negative consequences of insufficient blood supply to tissues are reduced.
• The process of using glucose by cells that are in a state of oxygen starvation or metabolic depletion is stimulated. And this means that on the one hand, the concentration of glucose in the blood decreases, and on the other hand, tissue hypoxia decreases due to the active use of glucose for tissue respiration.
• Improves the synthesis of collagen fibers.
• The process of cell division is stimulated with their subsequent migration to areas where it is necessary to restore the integrity of the tissue.
• The growth of blood vessels is stimulated, which leads to an improvement in the blood supply to tissues.

The effect of Actovegin on enhancing glucose utilization is very important for the brain, since its structures need this substance more than all other organs and tissues of the human body. After all, the brain uses mostly glucose for energy production. Actovegin also contains inositol phosphate-oligosaccharides, the effect of which is similar to that of insulin. And this means that under the action of Actovegin, the transport of glucose to the tissues of the brain and other organs improves, and then this substance is quickly captured by cells and utilized for energy production. Thus, Actovegin improves energy metabolism in the structures of the brain and provides its needs for glucose, thereby normalizing the work of all parts of the central nervous system and reducing the severity of cerebral insufficiency syndrome (dementia).

Indications for use (Why is Actovegin prescribed?)

Various dosage forms of Actovegin are indicated for use in various diseases, therefore, in order to avoid confusion, we will consider them separately.

• Acceleration of wound healing and inflammatory processes on the skin and mucous membranes (abrasions, cuts, scratches, burns, cracks);
• Improving tissue repair after burns of any origin (hot water, steam, solar, etc.);
• Treatment of weeping skin ulcers of any origin (including varicose ulcers);
• Prevention and treatment of reactions to the effects of radiation exposure (including radiation therapy of tumors) from the skin and mucous membranes;
• Prevention and treatment of bedsores (only for Actovegin ointment and cream);
• For pre-treatment of wound surfaces before skin grafting in the treatment of extensive and severe burns (only for Actovegin gel).

Solutions for infusions and solution for injections (shots) Actovegin - indications for use. Solutions for infusions ("droppers") and solutions for injections are indicated for use in the same following cases:

• Treatment of metabolic and vascular disorders of the brain (for example, ischemic stroke, the consequences of a traumatic brain injury, impaired blood flow in brain structures, as well as dementia and impaired memory, attention, ability to analyze due to vascular diseases of the central nervous system, etc.);
• Treatment of peripheral vascular disorders, as well as their consequences and complications (for example, trophic ulcers, angiopathy, endarteritis, etc.);
• Treatment of diabetic polyneuropathy;
• Healing of wounds of the skin and mucous membranes of any nature and origin (for example, abrasions, cuts, incisions, burns, bedsores, ulcers, etc.);
• Prevention and treatment of lesions of the skin and mucous membranes when exposed to radiation, including radiation therapy of malignant tumors;
• Treatment of thermal and chemical burns (only for injection solutions);

Actovegin tablets - indications for use. Tablets are indicated for use in the treatment of the following conditions or diseases:

• As part of the complex therapy of metabolic and vascular diseases of the brain (for example, cerebrovascular insufficiency, traumatic brain injury, as well as dementia due to vascular and metabolic disorders);
• Treatment of peripheral vascular disorders and their complications (trophic ulcers, angiopathy);
• Diabetic polyneuropathy;
• Hypoxia of organs and tissues of any origin (this indication is approved only in the Republic of Kazakhstan).

Instructions for use

Ointment, cream and gel Actovegin - instructions for use

Various dosage forms of Actovegin for external use (gel, cream and ointment) are used for the same conditions, but at different stages of these diseases. This is due to various auxiliary components that give different properties to the gel, ointment and cream. Therefore, gel, cream and ointment provide scarring of wounds at various stages of healing with different types of wound surfaces.

• If the wound is weeping with copious discharge, then the gel should be used until the wound surface dries. When the wound dries up, it is necessary to switch to the use of a cream or ointment.
• If the wound is moderately wet, the discharge is poor or moderate, then a cream should be used, and after the wound surface has completely dried, switch to the use of an ointment.
• If the wound is dry, without discharge, then an ointment should be applied.

Rules for the treatment of wounds with gel, cream and ointment Actovegin

Actovegin tablets - instructions for use (adults, children)

Tablets are intended for use in the same conditions and diseases as injectable solutions. However, the severity of the therapeutic effect with parenteral administration of Actovegin (injections and "droppers") is stronger than when taking the drug in tablet form. That is why many doctors recommend always starting treatment with parenteral administration of Actovegin, followed by switching to taking tablets as a fixing therapy. That is, at the first stage of therapy, in order to quickly achieve the most pronounced therapeutic effect, it is recommended to administer Actovegin parenterally (by injections or "droppers"), and then additionally drink the drug in tablets to consolidate the effect achieved by injections for a long period of time.

Actovegin injections - instructions for use

Dosages and general rules for the use of Actovegin solutions

Figure 2 - The correct break off of the tip of the ampoule to open it.

• Metabolic and vascular disorders of the brain (traumatic brain injury, cerebrovascular insufficiency) - 5-25 ml of solution is administered daily for two weeks. After completing the course of injections of Actovegin, they switch to taking the drug in tablets in order to maintain and consolidate the achieved therapeutic effect. In addition, instead of switching to a maintenance pill, you can continue injecting Actovegin by injecting 5-10 ml of the solution intravenously 3-4 times a week for two weeks.
• Ischemic stroke - Actovegin is administered by infusion ("dropper"), adding 20 - 50 ml of solution from ampoules to 200 - 300 ml of saline or 5% dextrose solution. In this dosage, the drug is infused daily for a week. Then, in 200 - 300 ml of infusion solution (saline or dextrose 5%), add 10 - 20 ml of Actovegin solution from ampoules and inject at this dosage daily in the form of "droppers" for another two weeks. After completing the course of "droppers" with Actovegin, they switch to taking the drug in tablet form.
• Angiopathy (peripheral vascular disorders and their complications, for example, trophic ulcers) - Actovegin is administered by infusion ("dropper"), adding 20-30 ml of the solution from the ampoules to 200 ml of saline or 5% dextrose solution. In this dosage, intravenous infusion, the drug is administered daily for four weeks.
• Diabetic polyneuropathy - Actovegin is administered intravenously, 50 ml of a solution from ampoules, daily for three weeks. After completing the course of injections, they switch to taking Actovegin in the form of tablets for 4 to 5 months to maintain the achieved therapeutic effect.
• Healing of wounds, ulcers, burns and other wound damage to the skin - a solution is injected from 10 ml ampoules intravenously or 5 ml intramuscularly either daily or 3-4 times a week, depending on the rate of healing of the defect. In addition to injections, Actovegin can be used in the form of an ointment, cream or gel to accelerate wound healing.
• Prevention and treatment of radiation damage (during radiation therapy of tumors) of the skin and mucous membranes - Actovegin is injected with 5 ml of a solution from ampoules intravenously daily, in between radiation therapy sessions.
• Radiation cystitis - inject 10 ml of a solution from ampoules transurethral (through the urethra) daily. Actovegin in this case is used in combination with antibiotics.

Rules for the introduction of Actovegin intramuscularly

Actovegin solution for infusion - instructions for use

Solutions for infusion Actovegin are available in two varieties - in saline or dextrose solution. There is no fundamental difference between them, so you can use any version of the finished solution. Such solutions of Actovegin are available in 250 ml bottles in the form of a ready-to-use infusion (“dropper”). Solutions for infusion are administered intravenously by drip (“dropper”) or intra-arterially by jet (from a syringe, as intramuscularly). Drip injection into a vein should be carried out at a rate of 2 ml / min.

• Circulatory and metabolic disorders in the brain (traumatic brain injury, lack of blood supply to the brain, etc.) - 250-500 ml (1-2 bottles) are administered once a day, daily for 2-4 weeks. Further, if necessary, in order to consolidate the obtained therapeutic effect, they switch to taking Actovegin tablets, or continue to inject the solution intravenously, 250 ml (1 bottle) 2-3 times a week for another 2 weeks.
• Acute disorders of cerebral circulation (stroke, etc.) - 250 - 500 ml (1 - 2 bottles) are administered once a day, daily, or 3 - 4 times a week for 2 - 3 weeks. Further, if necessary, they switch to taking Actovegin tablets in order to consolidate the obtained therapeutic effect.
• Angiopathy (impaired peripheral circulation and its complications, for example, trophic ulcers) - 250 ml (1 vial) is administered once a day, daily, or 3-4 times a week for 3 weeks. Simultaneously with the "droppers" you can apply Actovegin externally in the form of an ointment, cream or gel.
• Diabetic polyneuropathy - 250 - 500 ml (1 - 2 bottles) are administered once a day, daily, or 3 - 4 times a week for 3 weeks. Next, be sure to switch to taking Actovegin tablets in order to consolidate the resulting therapeutic effect.
• Trophic and other ulcers, as well as long-term non-healing wounds of any origin - 250 ml (1 bottle) are administered once a day, daily, or 3-4 times a week, until the wound defect is completely healed. Simultaneously with infusion administration, Actovegin can be used topically in the form of a gel, cream or ointment to accelerate wound healing.
• Prevention and treatment of radiation damage (during radiation therapy of tumors) of the skin and mucous membranes - 250 ml (1 vial) are administered one day before the start, and then daily throughout the course of radiation therapy, and additionally for another two weeks after last irradiation session.

special instructions

With repeated intravenous, intramuscular or intra-arterial administration of Actovegin, the level of blood electrolytes (calcium, potassium, sodium, chlorine) and the percentage of water in the body (hematocrit) should be monitored.

Overdose

In the Russian official instructions for use, there are no indications of the possibility of overdose with any dosage forms of Actovegin. However, in the instructions approved by the Ministry of Health of Kazakhstan, there are indications that when using tablets and solutions of Actovegin, an overdose may occur, which is manifested by pain in the stomach or increased side effects. In such cases, it is recommended to cancel the use of the drug, perform a gastric lavage and carry out symptomatic therapy aimed at maintaining the normal functioning of vital organs and systems.

Influence on the ability to control mechanisms

Not a single dosage form of Actovegin (ointment, cream, gel, tablets, solutions for injections and solutions for infusions) affects the ability to control mechanisms, therefore, against the background of the use of the drug in any form, a person can engage in any type of activity, including those requiring high speed of reactions and concentration of attention.

Interaction with other drugs

Forms of Actovegin for external use (gel, cream and ointment) do not interact with other drugs. Therefore, they can be used in combination with any other means for oral administration (tablets, capsules) and for topical use (creams, ointments, etc.). Only if Actovegin is used in combination with other external agents (ointments, creams, lotions, etc.), a half-hour interval should be maintained between the applications of the two preparations, and not smeared immediately after each other.