Irifrin: instructions for use for eye drops. Irifrin BK: description of eye drops, rules for use Irifrin BK eye drops instructions for children

In the pharmacy today you can find many different eye products.

Some drugs are used not only in the treatment of various diseases, but also for their diagnosis.

Medications that cause dilation of the pupil are necessary when examining an ophthalmologist - only they allow you to fully explore the fundus.

Among them is Irifrin BK. Consider this drug in more detail.

Instructions for the drug

Release form, composition

Irifrin BK is sold in drops poured into plastic dropper bottles with a capacity of 0.4 ml. One carton of the drug contains fifteen vials.

It is a colorless or yellowish liquid, which is a 2.5% solution of the active substance - phenylephrine, as well as auxiliary components.

As follows from the abbreviation "BK", the preparation does not include preservatives, which reduces the risk of irritation and allergic reactions during application.

Pharmacological effects

Phenylephrine is an adrenomimetic - an artificially obtained analogue of norepinephrine. The hormones of this group have a strong vasoconstrictive effect.

When applied topically, they act locally on the vessels of a particular organ, with virtually no systemic effect on the entire body.

Once in the conjunctival sac, phenylephrine is rapidly absorbed through the mucosa. This causes vasoconstriction, due to which redness of the eyes, which often accompanies overwork or irritation of the mucous membrane, goes away. Pupil dilation occurs. Fluid drainage is activated, due to this intraocular pressure drops.

The mydriasis caused by Irifrin BK occurs 10-50 minutes after the introduction of drops into the eye and lasts about two hours. Blood vessels narrow much faster: 30-80 seconds are enough for this.

Indications for use

The range of indications of Irifrin BK is quite wide. It is applicable as a medicine in such cases:

1. Iridocyclitis (inflammation of the iris of the eye).
2. Glaucoma-cyclic crisis.
3. False and genuine myopia.

In addition, this drug is necessary for:

1. Angle-closure glaucoma test.
2. Diagnosis of external and deep infection of the eyeball.
3. Visual examination of the fundus - ophthalmoscopy.
4. Preparations for surgery.

Method of application and dosage of the drug

Irifrin BK is injected under the eyelid using a dropper bottle.

In order to instill the drug, you need to pierce with a needle or carefully cut off the tip of the bottle (when piercing with a needle, it is more convenient to gently squeeze out a drop, more than necessary can pour out of the larger hole formed during the incision), then, raising your head up, pull the lower eyelid and squeeze one drop of solution under it.

After the introduction of the drug for a couple of hours, it is forbidden to read, use a computer and engage in other activities that require eye strain.

Irifrin BK does not contain preservatives, therefore the opened bottle cannot be reused, and even if there is some liquid left, it is better to throw it away.

Depending on the pathology, the dosage of Irifrin BK can vary markedly. In the treatment of iridocyclitis, the drug is instilled into the affected eye drop by drop 2-3 times a day.

This reduces the amount of effusion in the outer chambers of the eye and prevents the growth of synechiae. The course of treatment usually lasts from 5 to 15 days, its duration depends on the degree of the inflammatory process.

In the treatment of true and false myopia, a drop of Irifrin BK is injected into each eye at bedtime three times a week for a long (from a month) period.

The same schedule and dosages are used to eliminate accommodation spasm, then the medicine is used throughout the entire period of increased eye strain.

For diagnostic purposes, when glaucoma is detected, it is instilled once a drop of the drug. If the difference in intraocular pressure before the introduction of the solution and after the onset of persistent mydriasis is 3-5 mm. rt. Art., then the test result is considered positive.

When diagnosing the depth of the inflammatory process, one drop of Irifrin BK is also injected once. Here, the indicator becomes the time for the decline in redness of the eye: if it passes in about 5 minutes, then the infection is considered superficial, when it persists longer - that is, there is reason to suspect deep tissue damage.

Interaction with other drugs

Instillation together with atropine increases mydriasis and may lead to tachycardia.

Taking MAO inhibitors is fraught with a strong jump in blood pressure, therefore, in such cases, Irifrin BK is not recommended. It is important to remember that the risk of arterial hypertension persists for at least three weeks after discontinuation of MAO inhibitors, as they have cumulative properties.

The same consequences and cardiac arrhythmias are fraught with the use of Irifrin BK during treatment with antidepressants and m-anticholinergics.

Its use with beta-blockers also leads to pressure surges. Sympathomimetic drugs increase the vasoconstrictive effect of Irifrin BK.

Contraindications and side effects

The use of Irifrin BK is prohibited when:

• individual intolerance to the components;
• angle-closure or narrow-angle glaucoma;
• old age, aggravated by diseases of the cardiovascular system and the brain;
• hepatic porphyria;
• deficiency of glucose-6-phosphate dehydrogenase;
• prematurity.

Carefully prescribed for hereditary anemia, diabetes mellitus, age less than 1 year and more than 65 years, in the period after surgery and when wearing contact lenses.

Use during pregnancy and lactation is possible, but undesirable, since a detailed study of the effect of the drug on the embryo and the excretion of the active substance with milk has not been carried out.

Side effects of Irifrin BK can be both local and general.

Common side effects: dermatitis, hypertension, cardiac arrhythmias, pulmonary embolism (infrequently). In exceptional cases, there are such serious consequences as a heart attack, stroke, vascular collapse.

Overdose

When the dose is overestimated, tachycardia, dizziness, nausea and vomiting, sweating, anxiety, sluggish weakened breathing occur.

There are no specific antidotes, treatment is symptomatic. Phentolamine has proven itself well.

Terms and conditions of storage

The shelf life of the drug in unopened vials is 2 years. The temperature should not exceed 25 degrees, it should be inaccessible to children and protected from sunlight. Opened vials are not subject to storage.

Price

Analogues

The list of analogues of Irifrin BK includes its synonyms - medicines containing the same active substance, and analogues - medicines similar in effect, but different in composition. The first ones include:

1. Neosynephrine-Pos.
2. Synephrine.

It should be noted that they are all much cheaper, for example, the cost of Mezaton does not exceed 55 rubles.

The following drugs partially intersect in scope with Irifrin BK:

• Naphazoline;
• Tetrizoline;
• Oxymetazoline.

Release form

Compound

Active ingredient: Phenylephrine Excipients: Disodium edetate, sodium metabisulphite, citric acid, sodium citrate dihydrate, hypromellose, water for injection. Active ingredient concentration (mg): 25 mg

Pharmacological effect

Adrenomimetic. It has a direct stimulating effect mainly on α-adrenergic receptors. When used systemically, it causes narrowing of arterioles, increases peripheral vascular resistance and blood pressure. Cardiac output does not change or decreases, which is associated with reflex bradycardia (increased vagal tone) in response to arterial hypertension. Phenylephrine does not increase blood pressure as sharply as norepinephrine and epinephrine, but acts more long-term. This, apparently, is due to the fact that phenylephrine is more stable and does not collapse under the influence of COMT. When applied topically, phenylephrine has a pronounced vasoconstrictive effect, causes mydriasis, and can lower intraocular pressure in open-angle glaucoma. In average therapeutic doses, it practically does not affect the central nervous system.

Pharmacokinetics

After oral administration, phenylephrine is poorly absorbed from the gastrointestinal tract. It is metabolized with the participation of MAO in the intestinal wall and during the first passage through the liver. The bioavailability of phenylephrine is low. After topical application, it undergoes systemic absorption.

Indications

Iridocyclitis (to prevent the occurrence of posterior synechia and reduce exudation from the iris). Pupil dilation during ophthalmoscopy and other diagnostic procedures necessary to monitor the condition of the posterior segment of the eye, during laser interventions on the fundus and vitreoretinal surgery. Conducting a provocative test in patients with a narrow anterior chamber angle profile and suspected angle-closure glaucoma. Differential diagnosis of superficial and deep injection of the eyeball. Red eye syndrome (to reduce hyperemia and irritation of the mucous membrane of the eye). Prevention of asthenopia and spasm of accommodation in patients with high visual load. Treatment of false myopia (accommodation spasm) and prevention of the progression of true myopia in patients with high visual load.

Contraindications

Hypersensitivity to the components of the drug. Narrow-angle or closed-angle glaucoma. Arterial hypertension in combination with ischemic heart disease, aortic aneurysm, atrioventricular block I-III degree, arrhythmia. Tachycardia. Type I diabetes mellitus in anamnesis. Constant use of monoamine oxidase inhibitors, tricyclic antidepressants, antihypertensive drugs. Additional expansion of the pupil during surgical operations in patients with violation of the integrity of the eyeball, as well as in violation of tear production. Reduced body weight in newborns. Hyperthyroidism. Hepatic porphyria. Congenital deficiency of glucose-6-phosphate dehydrogenase. breastfeeding period. With caution In patients with type II diabetes - an increased risk of high blood pressure. In elderly patients, an increased risk of reactive miosis. Exceeding the recommended dose of a 2.5% solution in patients with injuries, diseases of the eye or its appendages, in the postoperative period, or with reduced tear production may lead to increased absorption of phenylephrine and the development of systemic side effects. Due to the fact that it causes conjunctival hypoxia - in patients with sickle cell anemia, when wearing contact lenses, after surgical interventions (decreased healing). With cerebral atherosclerosis, long-term bronchial asthma. Pregnancy and lactation In animals in late pregnancy, phenylephrine caused fetal growth retardation and stimulated the early onset of labor. The action of Irifrin in pregnant women has not been sufficiently studied, therefore, the drug should be used in this category of patients only if the expected benefit to the mother outweighs the risk of possible side effects for the fetus. If the drug is prescribed during lactation, breastfeeding should be discontinued.

Precautionary measures

Use during pregnancy and lactation

Adequate and strictly controlled clinical studies of the safety of the use of phenylephrine during pregnancy and lactation have not been conducted.

Dosage and administration

When conducting ophthalmoscopy, single installations of a 2.5% solution of Irifrin are used. As a rule, to create mydriasis, it is enough to introduce 1 drop of a 2.5% solution of Irifrin into the conjunctival sac. The maximum mydriasis is reached in 15-30 minutes and remains at a sufficient level for 1-3 hours. If it is necessary to maintain mydriasis for a long time, Irifrin can be re-installed after 1 hour. For diagnostic procedures: as a provocative test in patients with a narrow anterior chamber angle profile and suspected angle-closure glaucoma, 1 drop of the drug is instilled once. If the difference between the values ​​of intraocular pressure before instillation of Irifrin and after pupil dilation is from 3 to 5 mm Hg. Art., then the provocative test is considered positive; for differential diagnosis of the type of injection of the eyeball, 1 drop of the drug is instilled once: if 5 minutes after instillation, narrowing of the vessels of the eyeball is noted, then the injection is classified as superficial, while maintaining redness of the eye, it is necessary to carefully examine the patient for the presence of iridocyclitis or scleritis, as this indicates expansion of deeper vessels. In iridocyclitis, to prevent the development and rupture of already formed posterior synechiae and to reduce exudation into the anterior chamber of the eye, 1 drop of the drug is instilled into the conjunctival sac of the diseased eye 2-3 times a day for 5-10 days, depending on the severity of the disease. In schoolchildren with mild myopia, to prevent spasm of accommodation during a period of high visual load, 1 drop of Irifrin is instilled in the evening before bedtime, with progressive moderate myopia 3 times a week in the evening before bedtime, with emmetropia - in the daytime, depending on the load. In case of hypermetropia with a tendency to spasm of accommodation with high visual load, Irifrin is instilled in the evening in combination with a 1% solution of cyclopentolate. With normal visual stress, Irifrin is instilled 3 times a week in the evening before bedtime. In the treatment of false and true myopia, 1 drop of Irifrin is instilled in the evening before bedtime 2-3 times a week for a month.

Side effects

Local Conjunctivitis, keratitis, periorbital edema, eye pain, burning during installation, lacrimation, blurred vision, irritation, discomfort, increased intraocular pressure, blocking of the anterior chamber angle (with narrowing of the angle), allergic reactions, reactive hyperemia. Phenylephrine may cause reactive miosis the day after application. Repeated installations of the drug at this time may give less pronounced mydriasis than the day before. This effect is more common in older patients. Due to a significant reduction in the pupil dilator under the influence of phenylephrine, 30-45 minutes after installation, particles of pigment from the pigment sheet of the iris can be detected in the moisture of the anterior chamber of the eye. Suspension in the chamber moisture must be differentiated with manifestations of anterior uveitis or with the ingress of blood cells into the moisture of the anterior chamber. Systemic Contact dermatitis From the cardiovascular system: palpitations, tachycardia, arrhythmia, increased blood pressure, ventricular arrhythmia, reflex bradycardia, coronary artery occlusion, pulmonary embolism.

Overdose

An overdose of the drug is not described.

Interaction with other drugs

When using phenylephrine against the background of general anesthesia caused by halothane or cyclopropane, ventricular fibrillation may develop. With simultaneous use with MAO inhibitors, potentiation of the effects of phenylephrine is observed (including when applied topically). Phenothiazines, alpha-blockers (phentolamine), furosemide and other diuretics reduce the vasoconstrictor effect of phenylephrine. Guanethidine enhances the mydriatic effect of phenylephrine (with systemic absorption). Oxytocin, ergot alkaloids, tricyclic antidepressants, furazolidone, procarbazine, selegiline, sympathomimetics enhance the pressor effect, and the latter - and arrhythmogenicity. With the simultaneous use of beta-blockers reduce cardiac stimulating activity; against the background of reserpine, arterial hypertension is possible (due to the depletion of catecholamine reserves in adrenergic neurons, sensitivity to sympathomimetics increases).

special instructions

The use of phenylephrine in patients with severe hyperthyroidism should be avoided. Use with caution in coronary artery disease. When applied topically, after absorption through the mucous membrane, phenylephrine can cause systemic effects. In this regard, the use of phenylephrine in the form of 10% eye drops should be avoided in infants and elderly patients.

Irifrin is a sympathomimetic (a drug with alpha-adrenergic action), which is used topically (externally) in ophthalmology to dilate the pupil, constrict blood vessels and reduce intraocular pressure.

The need for the use of this drug increases with the differential diagnosis of the eyeball, false myopia, red eye syndrome and other conditions that disrupt the visual system, worsen the general well-being of a person.

On this page you will find all the information about Irifrin: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Irifrin eye drops. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Alpha-agonist for topical use in ophthalmology (mydriatic).

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Irifrin cost? The average price in pharmacies is at the level of 550 rubles.

Release form and composition

Dosage form of Irifrin - drops. They are a clear solution of a colorless or yellowish tint. Produced in special 5 ml plastic bottles with a dispenser, which, in turn, are packed in cardboard boxes.

• Drops come in different percentages of 2.5% and 10%. The active active ingredient is phenylephrine hydrochloride.
• 1 ml of a 2.5% solution contains 25 mg of the active ingredient, and 1 ml of a 10% solution contains 100 mg.

Additional components in the composition of the drug: benzalkonium chloride, disodium edetate, hypromellose, sodium metabisulfite, citric acid, sodium citrate dihydrate, distilled water.

Pharmacological effect

The active substance Irifrin phenylephrine is an alpha-adrenergic agonist, respectively, has an effect on the smooth muscles of blood vessels. When using phenylephrine in the form of eye drops, the drug affects only the vessels of this organ. If phenylephrine is administered intravenously or subcutaneously, it affects all the vessels in the human body, as well as the heart.

The application of Irifrin drops to the mucous membrane of the eye causes pupil dilation, increases the outflow of intraocular fluid, and also constricts the blood vessels of the conjunctiva. Constriction of the vessels of the conjunctiva ensures the disappearance of redness of the eye, as a result of which the drug is used in the treatment of "red eye" syndrome. Increased outflow of intraocular fluid improves the condition of the eye in glaucoma. And the expansion of the pupil, caused by drops of Irifrin, is used for preoperative preparation or in the process of performing surgical intervention on the eyes.

Narrowing of the vessels of the eye occurs within 30 - 90 seconds after the drops are applied to the conjunctiva. Pupil dilation occurs 10-60 minutes after a single instillation of the solution, and persists for 2 hours when using 2.5% Irifrin or 3-6 hours when using 10% drops.

Indications for use

Both varieties of Irifrin are intended for use in ophthalmology. Drugs are prescribed for the following conditions:

• different etiology;
• in the treatment of glaucoma and cyclic crises, accompanied by jumps in intraocular pressure;
• burst blood vessels in the eyes (red eye syndrome);
• iridocyclitis (extensive inflammatory process in the ciliary body of the eye);
• the need to expand the pupil in the process of carrying out diagnostic procedures;
• in order to eliminate accommodative spasm, that is, the reduction of ciliary muscle fibers;
• implementation of a provocative test in case of suspected closed-angle;
• the need to dilate the pupil in preparation for surgery and during laser surgery (drops with a 10% concentration).

In addition, the drug is often used in the differential diagnosis of superficial and deep injection of the eye. Irifrin bk eye drops are used in the treatment of true and false myopia (nearsightedness).

Contraindications

• hyperthyroidism;
• hepatic porphyria;
• children's age up to 12 years (eye drops 10%);
• premature (eye drops 2.5%);
• angle-closure or narrow-angle glaucoma;
• arterial aneurysm (eye drops 10%);
• hypersensitivity to the drug;
• congenital deficiency of glucose-6-phosphate dehydrogenase;
• elderly patients with serious disorders of the cardiovascular system and cerebral circulation;
• for additional expansion of the pupil during surgical operations in patients with violation of the integrity of the eyeball, as well as in violation of tear production.

Irifrin should be used with caution in patients with diabetes mellitus due to the risk of developing an increase in blood pressure associated with impaired autonomic regulation, as well as in elderly patients due to an increased risk of reactive miosis.

With caution, Irifrin should be used simultaneously with MAO inhibitors, as well as within 21 days after stopping their intake.

Use during pregnancy and lactation

According to the instructions for use, the use of the drug during pregnancy and breastfeeding is possible after a thorough study by the doctor of the individual characteristics of the patient. If the potential benefit to the mother outweighs the possible risk to the fetus or child, the medication can be used, but under the strict supervision of a doctor.

Instructions for use

The instructions for use indicate that Irifrin in the form of eye drops is applied topically.

During ophthalmoscopy - single instillations of a 2.5% solution. To create mydriasis, it is enough to introduce 1 drop of 2.5% Irifrin into the conjunctival sac. The maximum mydriasis is noted after 15–30 minutes and persists for 1–3 hours. If it is necessary to maintain mydriasis for a long time, repeated instillation is performed after 1 hour.

In children over 12 years of age and adults with insufficient pupil dilation, as well as in patients with a rigid iris, a 10% solution in the same dosage is used for diagnostic pupil dilation.

When carrying out diagnostic procedures, a single instillation of a 2.5% solution is used:

1. Provocative test in patients with a narrow anterior chamber angle profile and suspected angle-closure glaucoma. The test results are considered positive in cases where the difference between the values ​​of intraocular pressure before the use of Irifrin and after pupil dilation ranges from 3-5 mm Hg;
2. Differential diagnosis of the type of injection of the eyeball. When narrowing the vessels of the eyeball 5 minutes after instillation, the injection is classified as superficial, while maintaining the redness of the eyes, the patient should be carefully examined for the presence of scleritis or iridocyclitis, since this indicates an expansion of the deeper vessels.

With iridocyclitis, a 2.5 or 10% solution is used to prevent the development and rupture of already formed posterior synechiae, as well as to reduce exudation into the anterior chamber of the eye. With these indications, one drop of Irifrin is instilled into the conjunctival sac of the affected eye(s) 2-3 times a day.

Due to the vasoconstrictor action of phenylephrine in glaucoma-cyclic crises, intraocular pressure decreases. This action is more pronounced when using 10% Irifrin. For the relief of glaucoma-cyclic crises, the drug should be instilled 2-3 times a day.

When preparing a patient for surgical interventions, 30–60 minutes before surgery, a single instillation of a 10% solution is carried out to achieve mydriasis. Repeated instillation of the drug is not allowed after opening the membranes of the eyeball.

Side effects

Patient reviews and instructions for use among ophthalmic side symptoms are called:

1. Common: burning sensation when instilled, eye pain, discomfort, conjunctivitis, keratitis;
2. Moderately common: increased intraocular pressure, periorbital edema, blockade of the anterior chamber angle, allergic symptoms, reactive hyperemia;
3. Rarely: reactive miosis, the presence of elements of the pigment sheet of the iris in the anterior chamber of the eye.

Manifestations from the systemic organs may be contact dermatitis (infrequently).

Among the side effects of the cardiovascular system, patient reviews are called: tachycardia and palpitations, arrhythmia, increased blood pressure.

The instruction refers to rare manifestations of occlusion of the coronary arteries, pulmonary embolism.

Overdose

With an overdose of the drug, the listed side effects are observed, but more pronounced. In such cases - immediately stop using the medicine, rinse the conjunctiva of the eye, seek qualified medical help.

To stop the negative effects of an overdose: anxiety, nervousness, sweating, dizziness, vomiting, increased heart rate, shallow and weak breathing, alpha-adrenergic receptor blockers are prescribed - phentolamine 5-10 mg intravenously.

special instructions

Due to the fact that the drug causes conjunctival hypoxia, it should be used with caution in patients with sickle cell anemia, when wearing contact lenses, after surgical interventions (reduced healing).

Exceeding the recommended dose when using eye drops of 2.5% in patients with injuries, diseases of the eye or its appendages, in the postoperative period or with reduced tear production (anesthesia) can lead to an increase in the absorption of phenylephrine and the development of systemic side effects.

drug interaction

1. Irifrin enhances the inhibitory effect on the cardiovascular system during inhalation anesthesia.
2. Atropine enhances the mydriatic effect of Irifrin with a parallel development of an increase in heart rate.
3. The vasopressor effects of phenylephrine are enhanced by propranolol, reserpine, guanethidine, m-anticholinergics and methyldopa.
4. Local anesthetics increase the duration of mydriasis.
5. Beta-blockers, when combined with Irifrin, weaken their hypotensive effect, which is dangerous for the development of a hypertensive crisis.
6. Monoamine oxidase inhibitors and tricyclic antidepressants against the background of the use of Irifrin increase the risk of developing uncontrolled arterial hypertension. The appearance of this effect can be avoided by not prescribing Irifrin within 3 weeks after the abolition of MAO inhibitors.

Irifrin is one of the broad-spectrum drugs for diagnostic and therapeutic procedures in ophthalmology. Doctors often prescribe it for adults and children over 6 years of age. What indications for its use exist, what precautions the patient should be aware of, and why it is better not to use the medicine without a doctor's prescription - we will analyze in our review.

Composition and mechanism of action

Irifrin (Irifrin) is an ophthalmic agent. According to the pharmacological classification, it belongs to mydriatics (means for dilating the pupils). When instilled in the eye medicine:

• promotes contraction of dilator muscles - due to this, mydriasis develops (an increase in the diameter of a round hole in the center of the iris);
• narrows the conjunctival arteries;
• facilitates the outflow of intraocular fluid through the drainage system of the eye into the episcleral veins, preventing its stagnation and the development of glaucoma.

When used locally at the doses recommended by a specialist the drug does not affect the functioning of the cardiovascular system and the brain. Its medicinal effect becomes noticeable after 10-50 minutes after a single instillation. It continues at the same time from 2 to 7 hours.

Indications

In ophthalmology, Irifrin is prescribed for:

• iridocyclitis - an inflammatory lesion of the iris and ciliary body of the eye;
• glaucoma-cyclic crisis;
• red eye syndrome;
• a spasm of accommodation, in which a person does not see objects in the distance due to disruption of the eye muscle;
• myopia (nearsightedness) to prevent the progression of the disease in conditions of high visual load;
• procedures for examining the fundus (ophthalmoscopy, diagnosing angle-closure glaucoma, laser vision correction, etc.).

What is the difference between drops Irifrin and Irifrin BK

Irifrin eye drops are manufactured in India by the pharmaceutical companies Promed Exports and Sentiss Pharma. There are several forms of release of the drug:

• eye drops with a dosage of 2.5%:
  • Irifrin 2.5%;
  • Irifrin BK 2.5%;
• eye drops with a dosage of 10%.

Irifrin 2.5% is a clear, colorless liquid with no particular taste or odor. In addition to phenylephrine, this dosage form includes distilled water, excipients and preservatives. The product is available in 5 ml dropper bottles, supplied with instructions for use and packed in a bright white-green cardboard box. The shelf life of an open bottle is 1 month. In pharmacies, such a dosage form costs an average of 470 rubles.

The composition of Irifrin BK does not include preservatives, which reduces the risk of irritation and allergic reactions.

Unlike the usual one, Irifrin BK does not contain preservatives and is produced in disposable dropper tubes with a volume of 0.4 ml. Each of them must be used immediately after opening. A white-blue cardboard box contains 15 such tubes and instructions. The average price of eye drops in a pharmacy is 670 rubles.

Dosage and reception

The method of using the drug for adults is determined by the doctor individually.

• For the correction of accommodation spasm in case of myopia, astigmatism or increased visual load a 2.5% solution is usually prescribed. Therapeutic dose - 1 drop in each eye at bedtime. The course of therapy is at least 4 weeks. With persistent spasm of the eye muscles, it is permissible to use a 10% solution under the supervision of a physician (no more than 2 weeks).
• With iridocyclitis it is recommended to instill 1 drop of Irifrin (2.5% or 10% - depending on the severity of inflammation) in each eye 2-3 times a day. Treatment continues for an average of one week. Perhaps a combination with metabolic, reparative (improving nutrition and healing the mucous membrane of the eye) agents, for example,.
• In glaucoma-cyclic crisis, associated with intraocular fluid retention and increased IOP, a 10% solution is prescribed at a dosage of 1 drop × 2-3 r / day. The course of treatment is set by the doctor.

Drops are also widely used for the diagnosis of ophthalmic diseases. Methods of using the drug are presented in the table below.

Despite the lack of evidence some patients use Irifrin drops to treat a runny nose. Indeed, the adrenomimetic phenylephrine can reduce the clinical manifestations of rhinitis by constricting the arteries of the nasal mucosa and reducing edema. But doctors do not advise to get involved in this method of therapy: it is better to use special vasoconstrictor nasal sprays (Nazol, Sanorin, Xymelin), which are also cheaper.

Irifrin for children

Irifrin children usually is prescribed for diagnostic procedures or prevention of myopia. Most of the ophthalmologist's patients are schoolchildren who face high visual load every day. According to statistics, myopia (nearsightedness) develops especially intensively at the age of 10-14 years.

Eye drops with a dosage of 10% are suitable for children over 12 years old!

Remember that a 2.5% solution of the drug is used for children over 6 years of age. In rare cases, eye drops can be prescribed to babies 3-5 years old under strict medical supervision. 10% drops are contraindicated in children under 12 years of age.

The method of using the drug depends on the diagnosed disease and the goals of therapy. The dosage of the drug for children and adults is usually the same. Standard treatment regimens are presented in the table below.

Contraindications and side effects

Irifrin is a serious medical drug that has a significant list of side effects. Among them:

• conjunctivitis;
• periorbital edema;
• blurred vision;
• profuse lacrimation;
• tachycardia (increased heart rate):
• arrhythmia;
• reactive increase in blood pressure;
• pulmonary embolism (complete or partial blockage of the pulmonary artery);
• contact dermatitis.

In rare cases, the use of 10% drops can lead to serious complications from the body - myocardial infarction, acute heart failure, cardiogenic shock.

Many complain that when the medicine is instilled, they sting or burn their eyes. This is an acceptable reaction in the first days of treatment, and usually the discomfort disappears after a few minutes. But with severe pain, swelling and redness of the eyes, you should immediately rinse them with cool boiled water and seek medical help.

The medicine is contraindicated in:

• angle-closure/narrow-angle glaucoma;
• hyperthyroidism / thyrotoxicosis;
• porphyria;
• genetic diseases accompanied by a deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• violations of the integrity of the membranes of the eye in trauma.

The drug is also not prescribed for infants and elderly patients suffering from chronic diseases of the heart and blood vessels.

Drug Interactions

The drug is not prescribed together with other mydriatics: possible enhancement of the drug effect.

Despite the local method of application, some of the phenylephrine enters the bloodstream. Therefore, with simultaneous treatment with Irifrin and drugs that affect the cardiovascular system, it can cause unwanted reactions. Be careful when using it together with MAO inhibitors, antidepressants, beta-blockers (especially propranolol), m-anticholinergics, methyldopa, adrenomimetics. If you need inhalation anesthesia, tell your doctor that you are being treated by an ophthalmologist.