Vitamin B12 in ampoules with full instructions for use. Cyanocobalamin (vitamin B12), injection (ampoules)

Content:

Variants of the forms of release of this vitamin, how they differ. In what cases is an injection administered, dosage calculation.

Vitamin B12 is an important element of vital activity, which tends to accumulate and gradually be consumed in the body. Most often, its name refers to a group of elements that have a similar structure, functions and properties. When there is a deficiency of the mentioned substances, B 12 is used in ampoules, which is considered the most relevant form of release. In this case, the introduction of the substance is carried out by injection.

Generally speaking, the action of the element is aimed at solving a number of problems - the regulation of vascular tone and respiration, the production of nucleic acids, the creation of new blood cells. In case of deficiency, symptoms such as dizziness, weight loss, gastrointestinal damage, and so on are possible. Below we will discuss in more detail what role vitamin B12 plays in ampoules, what are the features of its use, what are the contraindications and effects.

Vitamin Forms

Today, cyanocobalamin (the second name of group B 12) is available in several forms:

• In ampoules. This option is the most popular because of the convenience of dosing and maximum efficiency for the body.
• In tablets. The advantage is ease of use. Disadvantages - less rapid action, additional irritation of the walls of the gastrointestinal tract.
• Spray(drops).

The last two forms are more convenient, because they do not imply injections that are so unpleasant for patients. On the other hand, B 12 in ampoules shows greater efficiency, with its help the fastest possible action is ensured.

It is worth considering one more thing - taking a vitamin in the form of tablets does not give the expected result in case of damage to the ileum. In such a situation, failures occur in the production of the Castle factor, and, as a result, there are problems with the absorption of cyanocobalamin or another similar substance.

Indications for use

One of the main questions concerns the indications for taking this supplement. Many believe that it is allowed to be used in almost any disease. But it's not.

Indications for the use of vitamin B12:

• Anemia. The use of an element for the treatment of such a disease has become relevant since the first half of the last century. It is still used today to combat chronic manifestations of the disease and as maintenance therapy.
• Cirrhosis of the liver or its insufficiency. B12 is essential for the repair of cells and damaged tissues. This is achieved through accelerated cell metabolism.
• Hepatitis. It is allowed to use cyanocobalamin in the treatment of chronic hepatitis types A, B and C. Most often, this substance is used almost as the main therapeutic agent.
• Alcoholism. The appointment is made at the stage of restorative or maintenance therapy.
• Neuralgia. As practice has shown, B12 in injections is good for trigeminal neuralgia.
• CNS problems. Most often they are manifested by various neurotic conditions, psychological disorders and depression.

In addition to those listed above, the element helps in solving a number of additional problems - cerebral palsy, Down syndrome, peripheral system, and so on. In addition, the reception is useful when you are on a strict diet, in case of dermatological diseases (eczema, psoriasis and others), with long-term medication and problems with the gastrointestinal tract.

Contraindications and side effects

Before starting the reception, it is worth considering the negative features that the vitamin possesses. Treatment with the use of such a drug is prohibited in the following cases - with erythremia, thromboembolism, hypersensitivity, erythrocytosis. In addition, the instruction forbidden to take in case of pregnancy and lactation.

There are also symptoms and diseases in which B12 should be taken with caution:

• angina;
• malignant and benign formations;
• tendency to form blood clots and others.

We must not forget about the negative effects that are possible in case of admission. It is worth noting the following side effects of the vitamin:

• risk of weakness and dizziness;
• headache;
• tachycardia;
• the appearance of problems with falling asleep;
• increased arousal;
• urticaria and others.

In the case of B12 injections, an overdose is possible (although this phenomenon is rare). It can be recognized by the following symptoms - thrombosis, heart failure, pulmonary edema. It is worth noting that with injections of this substance, it cannot be combined in one syringe with riboflavin and bromide.

Instructions for use and dosage

Now it’s worth moving on to no less important nuances - how much this vitamin should be taken in ampoules. It should be noted right away that the drug can be used orally, intralumbally, subcutaneously, intravenously and intramuscularly.

The dosage depends on the type of disease and is prescribed by a doctor:

• For Addison-Birmer anemia, the dosage is 100-200 mcg. Reception is carried out under the skin, once every 2 days.
• In the case of funicular myelosis, as well as in violation of the functions of the central nervous system, the dosage is 400-500 mcg in a day. Reception for the first seven days is carried out daily, after which small intervals are provided. To increase efficiency, folic acid is added to the course.
• In case of iron deficiency or post-hemorrhagic anemia, the dosage 30-100 mcg/dose. Frequency - 2-3 times a week.
• In the presence of failures in the peripheral and central nervous system, it is recommended to take 200-500 mcg once every two days. The duration of the course in this case is 14 days.
• If there are injuries of the peripheral nervous system, then the dosage is 200-400 mcg.
• Particular attention is paid to the use of the drug in liver diseases. How to take vitamin B12 in this case? Here the daily rate is 30-60 mcg. The second option is allowed, when 100 mcg of the supplement is taken every 2 days. The duration of the course is 25-40 days.
• An element is also prescribed for radiation sickness, when its norm is 60-100 mcg per day. The course in this case has a duration of 20-30 days.

The dosage should be planned according to the age of the patient. So, the daily portion is (for each of the ages):

• up to 6 months - 0.4 mcg;
• 7-12 months - 0.5 mcg;
• 1-3 years - 0.9 mcg;
• 4-10 years - 1.2 mcg;
• 11-14 years old - 1.8 mcg;
• 15-17 years old - 2.6 mcg;
• from 18 years and more - 2.8 mcg.

During lactation or pregnancy, the norm is 2.8-3.2 mcg.

Separate instructions for use

One of the most important points is confirmation of vitamin deficiency. This moment must be confirmed by appropriate diagnostics. As for the appointment, this procedure is allowed only for medical staff.

The entire stage of treatment under control is to keep the parameters of the periphery of the blood:

• So, 5-8 days after the start of the course, it is worth checking the volume of reticulocytes, the concentration of Fe.
• Every one to two weeks it is worth checking for the fact of the color index, the volume of Hb and erythrocytes.
• As soon as the number of erythrocytes reaches the level of 4-4.5 million / μl, remission can be expected. At the same time, poikilo- and anisocytosis disappears.
• As soon as it is possible to achieve hematological remission, the composition of the blood is monitored every 4-6 months.

In the process of taking the supplement, special care should be taken by a group of patients who are prone to the formation of blood clots and angina pectoris, in case of future gastrointestinal surgery or in case of pernicious anemia.

Preparations in ampoules

Above, we examined the features of vitamin B12, the instructions for which you need to know and follow unquestioningly. But we must not forget about the existence of several types of drugs that may differ in composition. Among them:

• cyanocobalamin- B12 in the form of a liquid with the addition of sodium chloride. Ampoules have a volume of 0.2 and 0.5 mg. The solution is administered intravenously, intramuscularly, under the skin or intralumbally. With sclerosis and myelosis, the introduction is carried out into the spinal canal.
• Neurobion- a product from the German manufacturer Merck. Reception is not recommended for breastfeeding, pregnancy, allergic reactions, under the age of 12 years. A feature of Neurobion is a combination of several vitamins - B12, B6 and B1.
• Neurorubin- Another drug that is available in ampoule form is considered an analogue of the previous one. It is used in some forms of sclerosis and anemia.
• Vitagamma- a remedy from a Russian manufacturer. In addition to vitamins of the B series (1, 6 and 12), the composition contains lidocaine, which relieves pain after injection. This drug is not recommended for use during pregnancy and children.

As I already wrote, both of us had it very low. Nevertheless, with such a low b12 (only 43), I consistently felt wonderful, but Serezha had fluctuations in well-being from super cool to shit (). After receiving the results of the tests, Serezha was sure that the reason was his low B12, so he decided to start taking it. And I wanted to take B12 to get rid of cellulite (the experience of russula shows that it really works, and how !!). We ordered b12 tablets - recommended to us by our friends Yulia and Paul, who have been on a raw food diet since 2009, just like me, and they are well versed in health issues, give advice, shoot videos, maintain a website. So, these are Jarrow Methylcobalamin B12 tablets, 1000mcg ($6.29 for 100 tablets). Those. methyl (methylcobalamin) b12 from Jarrow 1000 mcg per tablet. We ordered them from America, because. they are not sold in Russia, and it was necessary to wait for delivery for 3 whole weeks.

While we were waiting for our b12 tablets, we decided to start a course of injections. It turned out that almost every pharmacy sells b12 ampoules, but this is not methylcobalamin, but cyanocobalamin. 10 ampoules = 40 rubles; 10 syringes = 50 rubles. Ooooh, how scary it was to give an injection for the first time! Yes, and the next time is also a little points. From fear, every time before the injection, I wanted to go big in tubes: D That's honest!: D Some injections turned out to be barely sick, one was generally painless, I even wanted to ask Serezha why he didn’t give me an injection, and a couple of patients. We gave injections not in the thigh, as they recommend everywhere, but in the pope, because. it’s somehow more familiar or something))) In childhood, I think, almost everyone was given injections in the ass)))
Here is what is included in the composition of cyanocobalamin: cyanocobalamin 500 mg, sodium chloride 9g. In one ampoule 1 ml of liquid, of which 0.5 mg of cyanocobalamin itself - please do not confuse.
The first 2 injections went well, but right after the 3rd one, I felt like going to practice. Mind ward, it’s called ... My heart stabbed: (And it was beating furiously! For about an hour there was some kind of tachycardia, if I call it correctly - the heart was beating unstable, and this caused discomfort. Although they don’t write anywhere on the Internet and nowhere at all that immediately after b12 injections you can’t engage in high-intensity training. I slept badly that night, because my heart was beating strongly .. In the morning, it was like shortness of breath. And all the next day, the heart muscle ached - in the center, as if a little to the right and a little to the left of the very center .. it hurt to wipe off the table, open the drawer, move the laptop, open the pump for watering, tear off a twig from a tomato, wash my hands, hug Serezha. The next day I slept well, and in general it became normal, but this central muscle still ached a little.I climbed into the Internet and subtracted about the following side effects from b12 injections: 1) A rapid heartbeat - rapid heartbeat; Heart palpitations - arrhythmia; Chest pain - chest pain; A feeling of tightness in the chest - a feeling of heaviness in the chest; Difficulty breathing - breathing problems; Shortness of breath with mild exertion or when lying down - shortness of breath. In general, I gave the next injection only after 2 days.
In general, b12 injections are recommended to be given as follows:
- With super-low b12 like mine: the first week every day, the second week every other day, the 3rd week after two days, the 4th week once a week, and then every 3 months to maintain the level of b12.
- If the level is not so low, but for example 100-200, then the injection scheme is as follows: every day for a week, then one injection per week for a month, and then every month, and then every 3 months to maintain.
In general, then my heart revived, I relaxed, so to speak, and again, almost immediately after the injection, I began to play sports, but in a different way - push-ups, lunges, squats, etc. And even so - at first she made an injection, then immediately ate a super-satisfactory meal and immediately began to do upright. My heart a little pricked, but in the morning I grabbed it specifically ((Very prickly ((Like in childhood ... I used to have such nonsense, I didn’t even go to the gym, the doctors said it was vegetative-vascular dystonia.
So in total I gave 9 injections of cyano-b12. The last injection was June 6th. And on June 11, she again passed the analysis, in the same laboratory, for reliability. B12 went up from 43 to 645. And Serezha's from 46 to 497, although he gave 12 injections, i.e. three more than me. It is strange that I have more of it, because there were fewer injections!!

And recently our methyl-b12 pills from Jarrow came. If in each injection we received 500 mg of b12 (as it is written on the package, although probably still 500 mcg), then with these tablets 1000 mcg. We have been taking these pills since June 11th. Those. first they passed a second analysis, and then they began to drink b12 tablets. We took the first pills at 8 o'clock in the evening, and both could not fall asleep for a long time, they lay half asleep, it felt like they had run 10 km !! The next time there was no such thing, but now I noticed such a chip in myself that if I overeat, my heart starts to tingle .. not hellishly, but tensely. Especially if you eat dish mania from the heart in the evening and go to bed with a slightly full stomach .. Looks like the stomach presses on the heart, so discomfort. I remember that even before taking b12, I once had a strong heart attack when we were on the island this winter. Then I cracked up in the market of all sorts of fruits, and kaaaak grabbed my heart ... Plus, then I was hellishly sleepy for 4-5 days ... Then I slept off and after 2 days the pain in my heart disappeared. After that, I stuffed a full belly a hundred times, there was nothing. And then after b12 again: (There is only one conclusion - do not overeat!)))) There are small portions, but more often. Although I, of course, have recently become accustomed to eating 3 times a day, but in large volumes.

And a little more about methyl-b12. Everywhere it is said that it is better than cyano. That, for example, in women's milk b12 is contained precisely in the form of methylcobalamin, and in human blood plasma too.
By the way, since the level of b12 has already risen to the desired level, then the maintenance dose of methyl b12 tablets is now 2000 mcg per week. Those. 2 tablets of 1000 mcg per week. Since I drank today on Monday, then the next time on Thursday. I will drink them on Mondays and Thursdays. Well, after a while, it will again be necessary to do an analysis to check.

I also read that methyl-b12 is excreted in bile in an amount of 0.5 to 8 mcg per day.
Among the side effects of Jarrow's methylcobalamin is: "sometimes there may be nausea, vomiting, diarrhea, headache, dizziness, tachycardia, agitation." And in cyano-b12 times 10 more side effects, and I indicated above only those that manifested themselves in me.

Here is the composition of Jarrow methylcobalamin:
“xylitol (xylitol), cellulose (cellulose, fiber), stearic acid (vegetable source), natural flavor (natural flavor), magnesium stearate (vegetable source) (magnesium stearate (vegetable source) ), citric acid (citric acid) and silicon dioxide (silicon dioxide).
No wheat, no gluten, no soybeans, no diary, no egg, no fish/shellfish, no peanuts/tree nuts.“
There is nothing particularly harmful))) Xylitol is a natural sugar. For example, from birch wood, etc.

I also read that methyl-b12 is much better absorbed by the body than cyano-b12. Only methylcobalamin tablets should not be swallowed, chewed or dissolved, but simply put under the tongue and do nothing. After 25-30 minutes, the tablet will dissolve itself. Thus, b12 does not enter the stomach, but immediately into the blood, that is, the effect is approximately the same as from injections.

Today, after receiving the analysis, it became psychologically easier for me because I no longer have a B12 deficiency))) Well, cellulite will disappear)))) They say that the first effect is noticeable a month after taking b12, but I already see it now;) Although I started taking b12 only on May 23, so even a month has not passed yet. Clarification - after a month, people usually notice that cellulite becomes a little less, and after a few more months it completely disappears.
So, psychologically, it became easier for me, although there are no changes in my state of health, well, there are no at all - both at the level of 43, which is 645. The same! And Serezha has the same nonsense - all the same mood swings and well-being ... And after the first 4-5 commercials injections, he was just mega-cool, he says that the pin was like from drugs, but then the swing started again: (What's the matter, it’s not clear ... Even on vegetarianism with milk and fish, this began. If anyone is in the subject, why there may be jumps in mood and well-being, please let me know)))

Now look at where and how Frehley gives himself a B12 injection (starting at 12:30 minutes):

Vitamin B12 is a water-soluble vitamin of group B. Unlike other substances of this group, it can accumulate in the human body, most of all in the liver, spleen, lungs and kidneys. It is absorbed in the small intestine and deposited in the liver.

It contains a cobalt ion, hence the other name - cyanocobalamin, or cobalamin. Cyanocobalamin is stable to light and heat, and is better preserved in food during heat treatment.

The activity of cyanocobalamin is very high, and the amount of vitamin B12 in foods is measured in micrograms. Accordingly, the need for it in humans is small.

The amount of vitamin B12 in foods (mcg / 100g):

• Beef liver - 60;
• Heart - 25;
• Oysters - 18;
• Trout - 7.5;
• Herring - 13;
• Cheese Russian - 1.5;
• Sardines in oil - 8.5;
• Rabbit meat - 4.3;
• Beef - 3.0;
• Sea bass - 2.4;
• Cod - 1.6;
• Dutch cheese - 1.1;
• Cheese Poshekhonsky - 1.4;
• Curd - 1.0;
• Chicken egg - 0.5;
• Cow's milk - 0.4;
• Kefir - 0.4;
• Butter - 0.1.

The main source of this vitamin for the body is animal products. Some cobalamin is synthesized in the intestine by its own microflora. Very small amounts are found in soybeans, hops, tops, spinach, green salad.

Vitamin B12 Intakes

Age determines the daily requirement for cyanocobalamin. So, in infants up to 6 months it is 0.4 mcg / day, in children from 6 to 12 months - 0.5 mcg / day, from 1 to 3 years this need increases to 1 mcg / day, from 4 to 6 years - up to 1.5 mcg / day. Children aged 7-10 years require 2 micrograms of vitamin per day, adolescents 11-17 years old, as well as adults - 3 micrograms per day. In pregnant and lactating women, the need is higher - 4 mcg / day.

There is another designation for the amount of vitamin B12 - in international units (IU). 1 IU corresponds to the activity of 1 µg of cyanocobalamin.

The metabolism of cobalamin in the body is very slow, and it takes at least 5-6 years to form its deficiency. If a person takes potassium supplements, then hypovitaminosis is formed several times faster.

If a person smokes, drinks alcohol, or is a vegetarian, then the need for vitamin B12 increases.

With excessive consumption of sweet, carbonated drinks, as well as with chronic diarrhea, the absorption of cyanocobalamin from the intestine worsens, which means that its intake into the body decreases.

If a person uses many different drugs, and especially contraceptives, the consumption of cyanocobalamin increases.

Importance of vitamin B12 in the body

Vitamin B12 plays a significant role in the biological processes of the body; together with other vitamins, it is involved in the metabolism of fats, proteins and carbohydrates, as well as:

• Participates in the formation of red blood cells - erythrocytes;
• Promotes the removal of homocysteine ​​from the body - an amino acid that contributes to the occurrence of strokes and myocardial infarctions;
• Reduces the content of fats and cholesterol in the body;
• Improves the availability of oxygen to cells during hypoxia;
• Takes part in the regeneration of damaged tissues, participating in the synthesis of nucleic acids;
• Promotes the formation of active forms of vitamin A;
• Participates in the formation of the hormone melatonin, which regulates biorhythms;
• It affects the reproductive system of men - it increases the content of spermatozoa in the gonads;
• Regulates the immune system;
• It is a catalyst for biochemical transformations of organic acids, as a result of which myelin is formed - a sheath of nerve fibers.

Vitamin B12 is very important for hair, for their growth and healthy appearance.

Vitamin B12 deficiency

Hypovitaminosis is formed when there is insufficient intake of cyanocobalamin with food, its absorption is impaired, and when certain drugs are taken. Signs of its deficiency are the following symptoms:

• Low content of hemoglobin, platelets and leukocytes;
• Disorders of the digestive system;
• Fatigue, irritability, depression;
• Feeling of numbness in the limbs and difficulty walking;
• Stomatitis, glossitis;
• Headache;
• visual disturbances;
• Painful menses.

Lack of vitamin B12 for hair leads to hair loss and early graying.

Too much vitamin B12

Hypervitaminosis of cyanocobalamin is rarely formed, if the dosage is not observed while taking vitamin B12 tablets or when it is administered parenterally.

The main symptoms of an overdose:

• Pulmonary edema;
• vein thrombosis;
• Urticaria or anaphylactic shock;
• Heart failure.

The use of cyanocobalamin for therapeutic purposes

As a medicine, vitamin B12 in ampoules or tablets is used for diseases such as hepatitis, anemia, sciatica, polyneuritis, chronic pancreatitis, multiple sclerosis, diabetic neuropathy, radiation sickness, cerebral palsy, peripheral nerve injuries, skin and allergic diseases.

Vitamin B12 tablets are better absorbed when taken with folic acid. It is used in the treatment of anemia at a dose of 30 to 200 mcg per day every other day, until remission is achieved.

Vitamin B12 in ampoules is used for intravenous, intramuscular, intralumbar and subcutaneous administration.

In case of neurological pathology, including pain syndrome, vitamin B12 is administered from 0.2 to 0.5 mg per injection in an increasing pattern, 1 time in 2 days, a course of up to 2 weeks.

Contraindications

Do not use vitamin B12 in ampoules and tablets in case of thromboembolism, erythrocytosis, individual intolerance. Cautious use requires concomitant angina pectoris.

Content:

When are vitamin B12 injections prescribed? How to determine the correct dosage and what possible side effects are important to consider.

B12 (cyanocobalamin) is a vitamin that is rightfully considered the key to the body. Its action is aimed at strengthening the immune system, regulating pressure, accelerating protein synthesis and normalizing sleep. To increase the effectiveness of the drug, it is prescribed in ampoule form. How to inject vitamin B12? What is the effect of cyanocobalamin on the body and what contraindications is important to remember in the process of taking? Each of the questions requires detailed discussion.

In medical practice, vitamin B12 (injections) has found wide application and appointed in the following cases:

• Polyneuritis, neuralgia and sciatica.
• Chronic anemia developing against the background of a lack of cyanocobalamin.
• Renal failure and cirrhosis of the liver.
• Peripheral nerve injuries, cerebral palsy.
• For prophylaxis when prescribing vitamin C, biguanides, PAS in an increased dosage.
• Alcoholism, prolonged feverish conditions.
• Skin diseases - atopic dermatitis, photodermatosis, psoriasis and others.
• Pathologies of the intestines and stomach associated with impaired absorption of B12.
• Tumors of the intestine and pancreas.
• Infectious diseases and stress conditions, kidney pathology.
• Down's disease, funicular myelosis.

The role of cyanocobalamin in the body

Vitamin B12 in injections next action:

• It accelerates the production of leukocytes, which are involved in the destruction of foreign and dangerous elements for the body. Thanks to this action, the immune system is strengthened.
• Eliminates depression, helps in the fight against stress, improves memory and normalizes brain activity.
• Increases the quality of spermatozoa and their activity in the stronger sex.
• With a decrease in the volume of incoming oxygen, it improves the ability of cells to “absorb” oxygen from the blood plasma. This feature is useful when diving or holding your breath.
• Protein production. Anabolic processes take place with the participation of cyanocobalamin. That is why the vitamin is recommended for athletes during the period of muscle growth.
• Normalization of the cycle of wakefulness and sleep. Regular intake of B12 helps the body adapt to changes in the cycle and relieves insomnia.
• Pressure regulation. Cyanocobalamin returns blood pressure to normal in hypotension.

• Pregnancy (admission is allowed at the discretion of the doctor). Studies have shown the risk of teratogenic effects of cyanocobalamin when taken in high dosage.
• Hypersensitivity to the active substance.
• Erythrocytosis, erythremia and thromboembolism.
• The period of feeding the child.

It is prescribed in limited doses (after consulting a doctor) in the presence of such problems:

• angina;
• tumors (malignant and benign);
• cyanocobalamin deficiency;
• tendency to thrombosis.

Before injecting B12, you should study the instructions, consult with your doctor and determine the dosage that is suitable for you. The drug is taken:

• orally (by mouth);
• under the skin;
• intravenously;
• intramuscularly;
• intralumbally (into the spinal canal).

The dosage depends on the type of disease:

• Anemia Addison-Birmer - 150-200 mcg per day, every 2 days.
• Funicular myelosis, macrocytic anemia - 400-500 mg first seven days(taken every day). Further, intervals of 5-7 days are made between injections. To increase efficiency, folic acid is prescribed in combination with B12. During remission, the dosage is reduced to 100 micrograms per day with a frequency of twice a month.
• Iron deficiency or posthemorrhagic anemia - 30-100 mcg. Frequency of reception - every other day.
• Aplastic anemia - 100 mcg per day. The drug is taken until a noticeable improvement in the condition of the body.
• CNS disorders - 300-400 mcg every other day. The course is 40-45 days.
• Cirrhosis of the liver or hepatitis - 40-60 mcg per day or 100 mcg every other day. Course - 25-40 days.
• Radiation sickness - 50-100 mcg. It is taken every day, the course is 20-30 days.
• Lateral aminotrophic sclerosis - 20-30 mcg with a gradual increase in dosage to the level 220-250 mcg.
• To eliminate the deficiency of cyanocobalamin (intramuscularly, intravenously) - 1 mcg once a day b. The course is 7-14 days. For preventive purposes, the drug is injected once a month at a dosage of 1 mcg.
• Premature babies, nutritional anemia in childhood - 30 mcg per day every day for 15 days.
• Cerebral palsy, Down's disease, dystrophy (childhood) - 20-30 mcg, once every two days. The drug is injected under the skin.

pharmachologic effect

Many are interested in what B12 injections are for, what they give. The main advantage of this form of the substance is its rapid entry into the blood, after which the drug has a homeopathic and metabolic effect. In the body, the element is converted into a coenzyme form, namely, cobamamide and adenosylcobalamin. The mentioned substances belong to the active forms of cyanocobalamin and are involved in the production of vital body enzymes.

Vitamin B12 is part of many enzymes, including those that reduce B9 to titrahydrofolic acid, and also has powerful biological activity. Also, the action of the substance is aimed at accelerating the formation of red blood cells, the accumulation of their compounds, as well as increasing tolerance to hemolysis. In addition, the drug is useful for the circulatory system by the ability to accumulate sulfhydral groups in the compounds of red blood cells. When taken in an increased dosage, prothrombin activity increases and cholesterol levels decrease. After completing the course, the work of the nervous system is normalized, the ability of tissues to recover increases.

Side effects and special instructions

Knowing the benefits of vitamin B12, why cyanocobalamin is injected and what the dosage should be is often not enough. Important to consider side effects from reception:

• Increased arousal.
• Allergic reactions, sometimes - urticaria.
• Pain in the region of the heart, palpitations.
• Violation of purine metabolism, hypercoagulability.

special instructions:

• Lack of cyanocobalamin can be confirmed diagnostically, before prescribing the drug. This is due to the ability of the substance to hide folic acid deficiency.
• Control of indicators of peripheral blood. On the 6-8th day after the start of treatment, it is worth determining the level of iron and the number of reticulocytes. In addition, it is important to keep under control the color index, the volume of hemoglobin and red blood cells. The check is carried out within 30 days once or twice a week. After 3-4 tests are enough for 30 days. If a level of 4-4.5 million / μl (for erythrocytes) is reached, checks are carried out less frequently - once every 5-6 months.
• In the presence of angina pectoris, a tendency to form blood clots, as well as during lactation and pregnancy, it is forbidden to exceed the dosage.

Interaction

It is not recommended to merge in one syringe cyanocobalamin in liquid form and ascorbic acid. A similar requirement applies to salts of heavy metals, as well as other B-group vitamins. The reason is that the cobalt ion, which is contained in B12, destroys and reduces the effectiveness of the substances mentioned above.

The intake of colchicine, salicylates, aminoglycosides and antiepileptic drugs leads to a deterioration in the absorption of B12. In the case of co-administration with thiamine and in the presence of allergies, the effect of the latter is enhanced. In the case of parenteral use, chloramphenicol reduces the hematopoietic effect of B12 (stimulation of erythro- and leukopoiesis) in anemia.

Co-administration with hormonal contraceptives is not recommended. In this case, the concentration of vitamin B12 in the blood decreases. It is also not allowed to combine with drugs whose action is aimed at improving blood clotting.

How to inject B12 correctly?

Self-administration of the drug cyanocobalamin is dangerous to health, so you should act only on the advice of a doctor. It is also important to know how to properly inject vitamin B12, and what rules should be observed in the first place:

1. Get all information, which concerns the dosage and contraindications of the drug. In the presence of an allergic reaction to cobalt or cobalamin, the injection is prohibited. Tell your health care provider about the following problems:
   • Colds or allergies.
   • Diseases of the liver or kidneys.
   • Lack of folic acid or iron.
   • Infectious diseases.
   • Taking medications that affect the bone marrow.
   • Pregnancy or plans to have a baby.

   

2. Decide on the form of cyanocobalamin. In the case of taking vitamins B 12 in injections, the benefit lies in the rapid entry into the blood and covering the deficiency of cyanocobalamin (especially important for anemia). Injections are also prescribed if, for various reasons, the vitamin is poorly absorbed from the gastrointestinal tract.
3. Get Vitamin B12 Dosage Recommendations. If the doctor decides on the advantage of the injectable form, he also determines the required dosage. During the course, it is worth taking blood tests to monitor changes in its composition and respond to changes in a timely manner.
4. Choose an injection site. It all depends on a number of factors - the availability of appropriate skills, age, dosage and type of disease. The following options are available:
   • Shoulder. Injections in this area are suitable for people in middle or young age. In old age, it will be difficult to make such an injection on your own. If the dosage exceeds 1 ml per day, then you should choose another injection site.
   • Hip. This part of the body is preferred by people who give injections on their own, or cyanocobalamin is administered to children under five years of age. The advantage of an injection in the thigh is the large volume of muscle and fat in this area. In this case, the injection is made in the lateral femoral muscle, located in the middle between the inguinal region and the patella, so it is impossible to miss.
   • Buttocks. The injection is usually done in the upper part of the gluteal muscle (left or right). It is worth trusting only a medical worker, because there is a large accumulation of blood vessels and the sciatic nerve passes through. If the injection is done incorrectly, then the risk of damage is high.
   • External thigh. An injection in this place is suitable for adults and children. This area is located on the side, near the pelvic bone. Many people choose this option because there is no risk of catching nerves and blood vessels.
5. Decide on the method of injection. There are two main methods to choose from:
   • Intramuscular injection. This method is the most common. In this case, the needle is inserted at a right angle and deeply inserted into living tissues. Cyanocobalamin immediately enters the muscles and enters the bloodstream within a few minutes.
   • subcutaneous injection. Here the drug is injected with a syringe at an angle of 45 degrees. The needle is inserted shallowly, and at the time of the injection, the skin is slightly pulled away from the muscles. With this type of injection, the shoulder is considered the best place.

   

6. Prepare everything you need for injection. Here you will need:
   • vitamin B12;
   • cotton balls;
   • syringe with a needle;
   • adhesive plasters;
   • container for disposal of needles;
   • alcohol.
7. Clean up the injection site. To do this, remove clothing to the side and provide access to the skin. Then soak the cotton in alcohol and wipe the area where the injection will be made. Treat the skin in circular motions. Wait until the surface is dry.
8. Rotate the cyanocobalamin container, remove the needle from the package and remove the protective cap.
9. Pull back the plunger of the syringe to draw up the required amount of liquid. After inserting the needle into the vial, push the air out of the syringe and draw out the required volume of liquid. Then tap the syringe so that the air bubbles rise up.
10. Inject. Here it is important to adhere to the following rules:
    • Pull back the skin to facilitate the introduction of the composition.
    • Deepen the needle at the required angle and press on the plunger until the liquid is completely squeezed out of the syringe. It is desirable that the muscles at this moment be relaxed.
    • During the injection of B12, monitor the contents of the syringe - there should be no blood in the container.
    • Lower the skin and remove the needle. It is recommended to remove the needle at the same angle.
    • Wet the injection site with a special swab, then clean the surface and stop the bleeding.
    • Apply a band-aid to the injection site to prevent harmful substances from entering the bloodstream.
    • Fix the lid on the coffee jar. For these purposes, use adhesive tape. After cutting a slot in the cover, sufficient for the passage of the needle. The product is then recycled.

Today it is not difficult to find information why vitamin B6 and B12 are injected, and also what the dosage should be. Despite this, it is forbidden to act independently and take the drug without a doctor's prescription. Otherwise, there is a risk of a negative effect of the vitamin on the body and the presence of side effects.

The lack of vitamins and microelements can become a source of various diseases. The body loses its tone, feeling unwell becomes more frequent, weakness in the muscles, headaches appear.

Products containing Vitamin B 12 and general information

It is unique in that it contains a high concentration of cobalt, participates in cell division and synthesis of tissues, bones, replenishes iron reserves. The substance is necessary for a person to be in a good mood and have strong nerves.

Substance found exclusively in food of animal origin:

• by-products: heart, kidneys.
• Seafood: the maximum concentration was found in oysters, crabs, scallops, lobsters.
• Fish: salmon, sardines, flounder, haddock.
• Non-fat dry milk.
• Cheese: Camembert, Limbargue, Cheddar.
• Egg yolk.

deficiency symptoms

Vitamin deficiency negatively affects the state of the nervous system, mental and physical well-being worsens, depressive states often develop. The occurrence of failures in the synthesis of carnitine worsens the oxidation processes occurring in cells and energy production. Vitamin B12 deficiency is manifested by the following symptoms:

• Constant bad mood.
• High fatigue, weakness.
• depressive states.
• Stuttering.
• Numbness of the limbs ()
• Inflammation in the mouth.
• Unpleasant odor emanating from the body.
• Soreness of ordinary women's periods.

The deficiency does not appear immediately, the first signs may appear after a few years. It is important to listen carefully to your body. If a person is constantly haunted by a bad mood, irritability and nervousness without a proper reason, it is recommended to review the diet and consult a therapist.

Oversupply Symptoms

• Allergic reactions.
• High levels of blood clotting.
• Increased excitability.

A high concentration of vitamin B 12 is easily eliminated. It is a water-soluble substance, so drinking plenty of water will help to remove excess during natural emptying.

Overdose

It is impossible to achieve an overdose by eating foods high in vitamin B12.. An excess of this substance can form if it is injected into the body. If the waste rate is exceeded - 3 mg - pulmonary edema, heart failure, thrombosis, urticaria may develop.

"Cyanocobalamin": instructions for use.

The active substance is (this is Vitamin B12). The drug has a strong biological activity, it is necessary for the implementation of normal hematopoiesis, as it helps to ripen red blood cells. Has a beneficial effect on kidney and liver function, the central nervous system, is involved in lipid metabolism and the synthesis of nucleic acids.

Compound

Indications

• Anemia of various etymologies.
• Cirrhosis of the liver.
• Myelosis.
• Hepatitis.
• Radiculitis.
• Polyneuritis.
• Neuralgic lesions of the trigeminal nerve.
• Cerebral palsy in children.
• Down's disease.
• Injury to peripheral nerves.
• Skin diseases.
• Multiple sclerosis (vitamins for memory and brain, will help to cope with these phenomena, in more detail.

Contraindications and side effects

The main contraindications include diseases such as angina pectoris, thromboembolism.

• Increased nervous excitement.
• Heart pain.
• Allergy.
• Tachycardia.

Dosage and use of "Cyanocobalamin" in ampoules

Adverse symptoms appear if the daily dose is exceeded several times.

Price, shelf life and storage rules

• Packing 10 ampoules at a dosage of 500 mcg - 23 rubles.
• Shelf life is 24 months.
• Store the drug in a dark place isolated from children, without exposure to humidity, at room temperature.
• In pharmacies, the drug is dispensed by prescription.

Analogues

• "Ankerman B 12"- vitamin solution for injections of German production. The international name is cyanocobalamin. Prescription drug. The price of 10 ampoules is 191 rubles.
• "Vitamin B 12". The active substance is cyanocobalamin. The drug is presented in the form of a solution for injection. A package consisting of 10 ampoules is available at a cost of 30 rubles.
• "Dodex". Solution of cyanocobalamin for injections of Turkish production. The average cost is 475 rubles.
• "Cyanocobalamin Darnitsa". Liquid dosage form of cyanocobalamin. The cost of packaging is 82 rubles for ten ampoules.