Pentalgin side effects. Rules for the appointment and use of pentalgin. Alcohol intake during treatment should be excluded

Content

The drug Pentalgin has an antispasmodic, analgesic effect. The drug suppresses inflammation in the body, normalizes body temperature. Pentalgin acts systemically. Do not take pills on your own. A preliminary consultation with the attending physician is necessary.

Release form and composition of Pentalgin

The drug is produced in the form of white or green film-coated tablets. Pentalgin is packaged in cell packs of 2, 6, 10 and 12 pcs. A carton pack contains 1-2 such packages, instructions for use are enclosed. The cost of 12 tablets is up to 100 rubles. Chemical composition:

Pharmacological action

Information about the pharmacokinetics of the drug is not presented in the instructions for use. Tablets Pentalgin - a combined drug, the therapeutic effect of which is provided by the interaction of active components: paracetamol, naproxen, drotaverine and pheniramine. Mechanism of action:

• Paracetamol. Relieves pain, removes fever. Effective in viral and infectious diseases.
• Caffeine. Expands the vessels of the myocardium, kidneys. Caffeine eliminates drowsiness, increases efficiency, is a pronounced psychostimulant.
• Naproxen. The component inhibits the synthesis of prostaglandins - mediators of inflammatory processes and pain. Naproxen anesthetizes, relieves inflammation, and normalizes body temperature.
• Drotaverine hydrochloride. The antispasmodic relaxes the smooth fibers of the muscle tissue of the urinary and gall bladders, uterus, blood vessels, and other internal organs.
• Pheniramine. Blocker of H 1 -histamine receptors, which relieves spasm, swelling, enhances the effect of paracetamol and drotaverine. Pheniramine has a moderate effect on the nervous system.

Indications for Pentalgin's use

Tablets are prescribed alone or as part of complex treatment. Among the medical indications are such pathological processes:

• pain of various etiologies: dental, muscular, menstrual, headache, postoperative, post-traumatic;
• radiculitis;
• spastic pains;
• recurrence of gallstone disease;
• spasms in chronic cholecystitis;
• hepatic, renal colic;
• neuralgia;
• fever and fever with colds, SARS, influenza.

Dosages and method of administration

Pentalgin is used orally. The tablets must be swallowed whole with plenty of water. The patient is prescribed a daily intake of 1 table. 1-3 times. The maximum dosage is 4 tablets. in a day. To reduce body temperature, Pentalgin is taken for 3 days, as an anesthetic - 5 days. The maximum course of treatment is no longer than 7 days.

drug interaction

The drug is part of complex therapy, therefore, when combined with certain medications, it can harm the patient's health. The instructions provide information about drug interactions:

• Barbiturates, tricyclic antidepressants, Rifampicin increase the risk of a hepatotoxic effect.
• Pentalgin enhances the effect of indirect anticoagulants, the therapeutic effect of uricosuric drugs.
• Inhibitors of microsomal oxidation reduce the hepatotoxic effect of Pentalgin.
• Naproxen in the composition of the drug weakens the diuretic effect of Furosemide, increases the toxicity of sulfonamides, Methotrexate, and the concentration of lithium in the blood.
• Drotaverine reduces the antiparkinsonian effect of Levodopa.
• The combination of pheniramine with tranquilizers, hypnotics, MAO inhibitors enhances the inhibitory effect on the central nervous system.
• Barbiturates, Primidone, anticonvulsants increase caffeine clearance.
• The metabolism of caffeine is reduced in combination with Cimetidine, oral contraceptives, Disulfiram, Ciprofloxacin, Norfloxacin.
• Diflunisal increases the concentration of paracetamol in the blood plasma by 50%, increases the risk of intoxication of the body.

Pentalgin is not prescribed simultaneously with other drugs containing paracetamol and NSAIDs (non-steroidal anti-inflammatory drugs). Otherwise, an overdose of the drug occurs, symptoms of acute intoxication appear.

Special instructions for admission

• In the complex treatment of influenza, colds and SARS, Pentalgin is prescribed with extreme caution.
• In the case of taking the drug for more than 1 week, it is required to monitor liver function, peripheral blood counts.
• When treating with Pentalgin, it is not recommended to drive a vehicle and power mechanisms, engage in intellectual activities.
• It is required to control laboratory parameters of blood. Important: paracetamol distorts the results of tests related to the study of glucose and uric acid in the blood.

Side effects

With intolerance to the body of the active components of Pentalgin, the patient's condition worsens. The same can happen when taking pills for more than a week. Treatment must be stopped immediately. Possible side effects are described in the instructions for use:

• blood system: thrombocytopenia, decrease in the level of leukocytes in the blood, anemia, agranulocytosis;
• digestive tract: gastralgia, nausea, vomiting, lack of appetite, impaired stool and liver function;
• nervous system: insomnia, dizziness, agitation, inhibition of reactions, lethargy, anxiety, tremor of the limbs, migraine, decreased concentration;
• urinary system: decreased kidney function, interstitial nephritis;
• cardiovascular system: tachycardia, arterial hypertension, arrhythmia;
• skin: angioedema, anaphylactic shock, urticaria, skin rash, other allergic reactions;
• other: tinnitus, decreased visual acuity.

Contraindications for use

Since Pentalgin has a systemic effect in the body, medical contraindications apply to all internal organs, systems:

• cardiovascular system: acute myocardial infarction, severe arterial hypertension, coronary artery bypass grafting, cardiac arrhythmias;
• respiratory system: polyps (neoplasms) in the nose, bronchial asthma, bronchospasm in history;
• digestive tract: exacerbation of chronic diseases of the digestive tract, gastrointestinal bleeding and predisposition to them;
• renal, hepatic insufficiency of a complicated form;
• hyperkalemia;
• pregnancy, lactation;
• individual intolerance to active substances, acetylsalicylic acid.

• diabetes;
• stomach ulcer;
• viral hepatitis;
• alcoholic liver damage;
• benign hyperbilirubinemia;
• deficiency of glucose-6-phosphate dehydrogenase;
• epilepsy.

Pentalgin's analogs

If Pentalgin does not help or causes side effects, it is recommended to choose its analogue. Brief characteristics of such medicines:

• Ibuprofen. The drug has anti-inflammatory, antipyretic, analgesic properties. It has several forms of release, is sold in a pharmacy without a prescription.
• Paracetamol. Inexpensive pills that quickly remove pain and eliminate febrile syndrome. The medicine is prescribed for pain in the muscles and joints, migraines, etc. It is important to follow the prescribed dosages.
• Analgin. A budget drug that lowers the temperature, suppresses inflammation and pain of different localization. The pharmacy is sold without a prescription. Compared to Pentalgin, it acts weaker.

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"Pentalgin" is a unique drug. Able to relieve pain of various origins in a matter of minutes. It is a combined medicine that not only eliminates pain, but also helps with fever, inflammation, so it is often used for colds. Like any medication, it should only be taken as directed by a doctor.

Description of the drug

The action of "Pentalgin" is based on its balanced composition, which includes five active components, these are:

• paracetamol;
• naproxen;
• caffeine;
• drotaverine hydrochloride;
• pheniramine maleate.

The drug has combined properties and combines anti-inflammatory, antipyretic, analgesic, and antispasmodic effects.

Indications for use

The Pentalgin medicine quickly and effectively relieves pain. What the medicine helps with will be written later in the article.

The drug is prescribed for various pains. This is a pain syndrome in the muscle tissue and the joint. Pain with sciatica and menstruation. The purpose of the tablets can be toothache and headache, neuralgia.

The drug is often prescribed for discomfort caused by spasm of smooth muscles. Usually it is cholecystitis, which occurs in a chronic form. The drug is used for cholelithiasis and renal colic. Tablets are indicated for postcholecystectomy syndrome.

The drug "Pentalgin" is used in the postoperative period, as well as after injury, when the pain is accompanied by an inflammatory process.

Contraindications

The drug "Pentalgin" is used for colds with fever and fever.

What the medication helps with has already been told, and now about when the medicine should not be used. A contraindication to its use is renal and hepatic insufficiency, which is in severe form. You can not use the medication in the presence of a duodenal ulcer and stomach, which is in the process of exacerbation.

It is forbidden to resort to taking "Pentalgin" with bronchial asthma, anemia, bronchospasm and leukopenia. Do not use tablets for respiratory depression, as well as for craniocerebral damage.

Do not prescribe the drug for severe hypertension, acute myocardial infarction and arrhythmias. Contraindications for use are alcohol intoxication, lack of glucose-6-phosphate dehydrogenase and glaucoma.
It is forbidden to take the drug to children under twelve years of age and with hypersensitivity to the constituent components of the drug.

The drug "Pentalgin": instructions for use

Tablets are taken orally with water. If there are no other prescriptions, then the medicine is taken 1 pill up to three times a day. The maximum permitted dosage is four tablets per day.

The duration of therapy, if the drug is used as an antipyretic, should not exceed three days, if as an anesthetic, then no more than five days. Perhaps, but only after consulting a doctor, a longer use of Pentalgin. Instructions for use of the tablet recommends drinking at the indicated dose in order to avoid overdose symptoms.

The drug "Pentalgin": reviews

This drug has stood the test of time. Some patients have a positive experience with its use, others have not received any result from its use. For a third, the drug caused side effects, and they never took Pentalgin again.

Positive reviews note its effectiveness in headache, menstrual and toothache. It is said to relieve migraine symptoms. It is a good antispasmodic. Helps with sciatica, as well as with intercostal colic. These persons claim that for the entire time of using the medicine, the pills have never caused a side effect. Many patients are pleased with the reasonable price of the drug and its availability, since the tablets can be found in any pharmacy.

Some people note that the medicine does not work immediately, but after 30-40 minutes. There are people to whom the drug did not help and they consider it an ineffective remedy. In some patients, the drug caused negative reactions, in the form of stomach pain, nausea and vomiting. In some cases, there was a loss of consciousness, tremor of the limbs.

People felt overly excited and slept poorly. Adverse reactions were experienced by patients who drank two Pentalgin tablets at once at the same time. For those who took half or one whole pill at a time, the remedy did not cause negative symptoms.

Forms of release of the drug "Pentalgin"

There are several forms of release of "Pentalgin". They differ from each other in their composition. Some of them are dispensed from pharmacies strictly by prescription. These are the drugs:

• "Pentalgin" contains paracetamol, caffeine, drotaverine hydrochloride, naproxen, pheniramine maleate. You don't need a doctor's prescription to buy it.
• Pentalgin N contains caffeine, metamizole sodium, naproxen, codeine and phenobarbital. Released by prescription. Contains analgin. May affect blood and urine test results.
• "Pentalgin ICN" contains paracetamol, phenobarbital, caffeine, metamizole sodium and codeine phosphate. Released by prescription.
• "Pentalgin Plus" includes substances such as paracetamol, caffeine, phenobarbital, propyphenazone and codeine phosphate.

All drugs have a complex effect and are composed of five active ingredients. An absolute indication for all types of drugs is the removal of pain of various origins.

List of analogues

If for some reason "Pentalgin" did not fit, then it can be replaced with another drug with a similar effect. The most common analogues include:

• "Analgin";
• "Sedalgin";
• "Tempalgin";
• "Nurofen";
• "Ibuprofen";
• "Panadol";
• "Askofen-P";
• "Next";
• "Citramon-P";
• "Maxigan";
• "Ketanov";
• "Baralgin";
• Spazmalgon.

These and other drugs can, if necessary, act as an alternative to Pentalgin. They stop pain, and some of them fight inflammation. Medications should be taken with the help of a doctor. To avoid side effects, do not change one drug for another on your own.

The medicine "Analgin"

The drug "Analgin" is a cheap analogue of "Pentalgin". It relieves pain of various origins, as well as fever and inflammation. It has many contraindications. The maximum daily dosage is eight tablets per day. The medicine is produced in the form of tablets and solution for injection. The duration of the drug should not exceed five days. Ten tablets of 500 mg cost around 20 rubles.

What works better "Analgin" or "Pentalgin"? There is no single answer to this question. With a cold, Pentalgin will be more effective, since it acts in a complex way. Both drugs are suitable for pain relief.

Substitute "Ketanov"

Another analogue of Pentalgin is Ketanov. Contains the active substance - ketorolac tromethamine. Not only relieves pain, but also removes inflammation. It has a slight antipyretic property. Begins to act half an hour after use. The maximum concentration in the blood is observed two hours after its use.

The drug is contraindicated in pregnant and lactating women, as well as in childhood. The maximum daily dosage is 4 tablets. The course of treatment should not exceed two days. Twenty tablets cost around 70-100 rubles.

What helps better for pain "Pentalgin" or "Ketanov"? Each of these drugs is designed to relieve a specific type of pain. Both drugs are quite serious and should not be taken without a doctor's prescription. Only a doctor, having assessed the patient's condition, will help to make the right choice.

The drug "Tempalgin"

The analogue of "Pentalgin" "Tempalgin" is well tolerated by patients. It is used to relieve headache, toothache and joint pain. It is used for injuries and bruises.

Contains metamizole sodium (analgin) and triacetamin. It is a non-narcotic analgesic. Helps eliminate fever and inflammation. Often used in the postoperative period. It should not be used by pregnant and lactating women and children under 15 years of age. The maximum permitted dosage is 6 tablets per day. The cost of 20 tablets fluctuates around 100-120 rubles.

What to choose for the treatment of "Pentalgin" or "Tempalgin"? The first has a more extensive composition, and, consequently, its spectrum of action is much wider. Contains caffeine, which is a stimulant, so this medicine should be used with caution at bedtime. "Tempalgin" is characterized by an anxiolytic property, soothes and relieves stress. Which one is more suitable for treatment, the patient must decide for himself, based on the recommendations of the doctor and personal preferences.

Analogue "Spazmalgon"

Sometimes people face the question of what is better to take: "Pentalgin" or "Spazmalgon"? There is no definite answer here. After all, there are many drugs to relieve pain, and each person, based on the tolerability of the drug and the effectiveness of the drug, chooses the most suitable medication.

The medicine "Spazmalgon" has three active components, these are:

• pitofenone hydrochloride;
• metamizole sodium;
• fenpiverinium bromide.

The lion's share in this composition falls on metamizole sodium (analgin). The drug is often used in neurology and gynecology to relieve pain.

The indication for use is migraine, toothache, as well as painful spasms of the intestines, stomach and urinary system. The drug is used for cholelithiasis and renal colic. The drug has contraindications and, if used incorrectly, can provoke a number of side effects.

Produced in tablets and in the form of a solution for injection. It, unlike Pentalgin, can be used by children from the age of 3 months.

The drug "Nurofen"

The drug "Nurofen" is another analogue of "Pentalgin". Available in the form of tablets, syrup, suppositories and capsules. Relieves toothache, headache, muscle and joint pain. Indicated for migraine, myalgia and neuralgia. Often used for influenza and SARS. The therapeutic course is 2-3 days. The cost of a children's suspension is 120 rubles per 100 ml. The price of eight capsules "Nurofen Express" fluctuates around 130-150 rubles.

What is better "Pentalgin" or "Nurofen"? According to the patients, "Pentalgin" acts more strongly, but side effects during its use appear more often. "Nurofen" these people consider a more benign medicine. It is noted that it quickly brings down the heat. Works flawlessly in diseases of the joints.

Medication "Baralgin"

The drug "Baralgin" is an analogue of "Pentalgin". Produced in the form of tablets and solution for injection. Renders antispasmodic, analgesic and antipyretic action. Removes pain syndrome of various genesis. Can be used in both adults and children. The price of 20 tablets is 200-250 rubles. Five 5 ml ampoules cost about 250-300 rubles.

Pentalgin is a combination drug that has anti-inflammatory, pyrolytic, antispasmodic and analgesic effects. This drug combines several components, which causes a wide range of its action.

Pentalgin is prescribed to patients suffering from various types of pain - headache, muscle, toothache, during menstruation, with post-traumatic and post-operative syndrome.

Pentalgin is available in tablets and acts on the patient for four hours.

What is Pentalgin

The drug consists of five substances: metamizole sodium, codeine, paracetamol, phenobarbital and caffeine. Sodium metamizole, paracetamol have anti-inflammatory and analgesic effects on the body. Codeine has an analgesic effect and inhibits arousal. Phenobarbital has a depressant effect on the nervous system.

Under the influence of caffeine, activity and working capacity increase, general well-being improves, lethargy disappears, brain vessels expand.

Indications for use

This drug is indicated for:

• Headache, toothache and other types of pain.
• Seizures.
• Painful postoperative syndrome.
• Pain post-traumatic syndrome.
• Pain during menstruation.
• Neuralgia.
• Muscle pain.
• Joint pains.
• Ishiase.
• Cholelithiasis, renal, hepatic colic.
• postcholecystectomy syndrome.

Contraindications

• Gastric ulcer and duodenal ulcer in the acute phase.
• Severe damage to the heart and blood vessels, liver disease (cirrhosis, hepatitis, liver failure) and kidney disease (renal failure).
• Bleeding in the stomach and intestines.
• Decreased bone marrow hematopoiesis.
• Hyperkalemia.
• (heavy).
• Individual intolerance to the components that make up Pentalgin.
• Heart rhythm disturbances.
• Operation coronary artery bypass grafting.
• Bronchial asthma.
• Increased concentration of potassium ions.
• The patient's age is less than 18 years.
• and breastfeeding period.

How to use Pentalgin?

One tablet of Pentalgin contains pheniramine maleate 10 mg, paracetamol 325 mg, caffeine 50 mg, naproxen 100 mg, drotaverine 40 mg. The drug must be washed down with water, without biting or crushing. The time between taking the tablets is 4 hours. Before taking this drug, it is advisable to consult a doctor so that he calculates the required dose of the drug for a day and determines the course of treatment. Do not take more than four tablets per day.

Children from 12 years of age, as well as adults, are allowed to take one tablet three times a day. When using Pentalgin as an analgesic, the course of admission is no more than five days, as a pyrolytic - three days. If there is a need to increase the course of admission, then you should consult your doctor and follow his recommendations.

Can Pentalgin be pregnant?

For the entire period of pregnancy and during lactation, the use of Pentalgin is not desirable. If the woman who has given birth takes this medicine, then the child is recommended to be transferred to artificial feeding.

Overdose

Symptoms: loss of appetite, cyanosis, nausea, possible vomiting, bleeding of the stomach and intestines, acute abdomen, confusion, increased motor activity and excitability, heart palpitations (tachycardia), heart rhythm disturbance (arrhythmia), hyperthermia, polyuria (frequent urination), tremor of the extremities, frequent headaches, increased levels of ALT, AST (liver transaminases), liver necrosis.

Signs of impaired hepatic function appear after an overdose after 12-48 hours.

Due to a severe overdose, the following conditions occur - acute kidney and liver failure, encephalopathy progresses, death, necrosis, pancreatitis, heart rhythm disturbance.

If there are signs of an overdose, you should immediately consult a doctor!

Treatment: in case of overdose, it is necessary to wash the stomach and take activated charcoal. Within 8 hours, it is desirable to introduce an antidote of paracetamol - acetylcysteine.

With bleeding in the stomach and intestines, the introduction of special agents (antacids), gastric lavage with 0.9% sodium chloride solution (ice), maintenance of lung ventilation, oxygenation, with epilepsy attacks - intravenous dizaepam, preservation of water-salt metabolism.

Side effects

Allergic manifestations:

• Itching, rash, urticaria, angioedema.

Hematopoiesis:

• An increase in the number of leukocytes and platelets, the absence of granulocytes.
• Methemoglobinemia, anemia.

Heart, vessels:

• Increased heart rate, heart rhythm disturbance, arterial hypertension.

Stomach, intestines:

• Ulcers, erosion of the stomach and intestines, nausea, vomiting, a feeling of heaviness and discomfort in the stomach, acute pain in the abdomen, accompanied by constipation; insufficiency of hepatic function.

Urinary system:

• Insufficiency of renal function.

Organs of vision and hearing:

• Hearing loss, increased pressure (and).

Pentalgin's analogs

Pentalgin ICN, Sedal-M, Sedalgin-neo, Pentalgin-N, Piralgin, Pentalgin Plus.

Pentalgin® - No. 1 in terms of sales in terms of money in the category "Analgesics" in 2018 in Russia*.

Pentalgin is a combined analgesic drug, with a unique formula** of five active ingredients, to relieve pain, inflammation and spasms.

Due to the combination of five components, Pentalgin® has not only analgesic and antispasmodic, but also anti-inflammatory and antipyretic effects. It helps to eliminate pain syndromes caused by a variety of reasons (inflammation, neurological diseases, trauma, spasm, etc.), reduce or relieve muscle, joint, menstrual, headache, toothache and other types of pain.

Indications for use

• Pain syndrome of various origins, including pain in the joints, muscles, sciatica, menstrual pain, neuralgia, toothache and headache (including headache caused by spasm of cerebral vessels).
• Pain associated with spasm of smooth muscles, including chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic.
• Post-traumatic and postoperative pain syndrome, including accompanied by inflammation.
• Colds, accompanied by febrile syndrome (as a symptomatic therapy).

Pentalgin is the choice of millions of Russians*

Pentalgin - a combined antispasmodic and anti-inflammatory drug.

pharmachologic effect

Pentalgin has antipyretic, analgesic, antispasmodic, and anti-inflammatory effects.

The therapeutic effect of the drug is due to the properties of the active components that make up Pentalgin:

• Naproxen belongs to the group of non-steroidal anti-inflammatory drugs and has analgesic, anti-inflammatory and pronounced antipyretic effect, which is associated with the normalization of prostaglandin synthesis;
• Drotaverine acts on the smooth muscles of the biliary tract, gastrointestinal tract, blood vessels and genitourinary system;
• Paracetamol has analgesic and antipyretic properties, which is due to the blockade of COX in the central nervous system and a depressant effect on the centers of thermoregulation and pain;
• Caffeine, which is part of Pentalgin, tones the vessels of the brain, causes the expansion of the blood vessels of the heart, skeletal muscles and kidneys, helps to eliminate the state of drowsiness. As a psychostimulant, caffeine increases the bioavailability of non-narcotic analgesics and increases the permeability of histohematic barriers, which enhances the therapeutic effect;
• Pheniramine has a mild sedative and antispasmodic effect and enhances the analgesic effect of the active ingredients of paracetamol and naproxen.

Since some active ingredients cross the placental barrier, it is not recommended to use Pentalgin during pregnancy.

Release form and composition of Pentalgin

Pentalgin is produced in the form of green biconvex film-coated tablets with "PENTALGIN" embossed on one side. Each tablet contains:

• 325 mg paracetamol;
• 50 mg caffeine;
• 10 mg pheniramine maleate;
• 100 mg naproxen;
• 40 mg of drotaverine hydrochloride.

12 tablets in cell packs.

Indications for Pentalgin's use

According to the instructions, Pentalgin is used for:

• Pain syndrome caused by spasm of smooth muscles that occurs with cholelithiasis, chronic cholecystitis, renal colic, postcholecystectomy syndrome;
• Colds, which are accompanied by a febrile syndrome;
• Pain syndrome of various origins, including headache, muscle and joint pain, sciatica, neuralgia, algomenorrhea, toothache;
• Post-traumatic and postoperative pain syndrome.

Contraindications

Pentalgin according to the instructions has a wide range of contraindications, namely:

• Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
• The combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses against the background of intolerance to acetylsalicylic acid or other nonsteroidal drugs;
• Severe renal failure;
• Condition after coronary artery bypass grafting;
• Paroxysmal tachycardia;
• Severe arterial hypertension;
• severe liver failure;
• Inhibition of bone marrow hematopoiesis;
• Severe organic diseases of the cardiovascular system, including acute myocardial infarction;
• Frequent ventricular extrasystole;
• Age up to 18 years;
• Hyperkalemia;
• Hypersensitivity to Pentalgin components.

• Cerebrovascular diseases;
• Diseases of peripheral arteries;
• Renal and hepatic insufficiency of mild or moderate severity;
• Alcoholic liver damage;
• epilepsy;
• Deficiency of glucose-6-phosphate dehydrogenase;
• Diabetes;
• Ulcerative lesions of the gastrointestinal tract in history;
• Viral hepatitis;
• Benign hyperbilirubinemia, including Gilbert, Dubin-Johnson and Rotor syndromes;
• Tendency to convulsive seizures.

How to use Pentalgin

According to the instructions, Pentalgin is taken orally one tablet at a time.. The maximum daily dose should not exceed 4 tablets. The duration of Pentalgin use depends on the symptoms:

• As an anesthetic, Pentalgin is taken up to five days according to the instructions;
• As an antipyretic, the drug should not be taken for more than three days. If during this time there is no improvement, it is recommended to consult a doctor for clarification of the diagnosis.

The possibility of a longer use of Pentalgin should be discussed with your doctor. In cases of the appointment of Pentalgin during pregnancy, the drug should be taken as soon as possible.

Do not exceed the doses of Pentalgin indicated in the instructions in order to avoid an overdose, which manifests itself as:

• Lack of appetite;
• gastrointestinal bleeding;
• Motor restlessness;
• Tachycardia;
• Frequent urination;
• Increased activity of hepatic transaminases;
• Headache;
• Increase in prothrombin time;
• Paleness of the skin;
• nausea, abdominal pain, vomiting;
• Excitation;
• confusion;
• Tremor or muscle twitching;
• Arrhythmia;
• Increase in body temperature;
• epileptic seizures;
• Hepatonecrosis.

Symptoms of impaired liver function may not appear immediately, but 12-48 hours after an overdose. Large doses of Pentalgin can lead to the development of coma, liver failure with progressive encephalopathy, arrhythmias, pancreatitis and death.

Long-term combination of Pentalgin with barbiturates, rifampicin, tricyclic antidepressants and ethanol should be avoided to avoid the development of a hepatotoxic effect.

The simultaneous use of Pentalgin with caffeinated drinks and other drugs that stimulate the central nervous system can lead to its excessive stimulation.

Side effects

In therapeutic doses, Pentalgin is well tolerated according to reviews.. In some cases, when using Pentalgin, violations of various systems may develop, which manifest themselves most often as:

• Skin rash, urticaria, itching, angioedema;
• Tremor, increased reflexes, agitation, headache, anxiety, sleep disturbances, decreased concentration, dizziness;
• Impaired liver function, vomiting, abdominal pain, epigastric discomfort, nausea, constipation;
• Impaired kidney function;
• Hearing loss, increased intraocular pressure in angle-closure glaucoma, tinnitus;
• Methemoglobinemia, anemia, thrombocytopenia, agranulocytosis;
• Arrhythmia, palpitations, increased blood pressure;
• Tachypnea, dermatitis.

If any of the symptoms described are observed while taking Pentalgin, you should stop treatment and consult a doctor.

Storage conditions

Pentalgin refers to non-prescription antispasmodic drugs with a shelf life of 24 months recommended by the manufacturer.

Sincerely,