Tsipromed (eye drops): instructions for children and reviews. Tsipromed eye drops: we fight infection for “one, two, three” Tsipromed ear drops were prescribed during pregnancy

The instructions for Tsipromed eye drops indicate that they are used to treat infectious diseases of the organs of vision.

The drug is effective, and is successfully used in otolaryngology.

It is used in ophthalmology and has positive feedback from patients.

Indications for use

Means for the treatment of organs of vision Tsipromed, produced by pharmacists in India. It is a sterile 0.3% colorless solution, the main therapeutic substance of which is ciprofloxacin hydrochloride, the remaining ingredients complement the composition of the medical product.

Benzahexonium hydrochloride, disodium salt with lactic acid, sodium chloride and hydroxide are dissolved in distilled water of the preparation.

Drops for eyes Tsipromed for eyes is issued in bottles in 5 ml. For ease of instillation and dosing, the bottles are equipped with droppers.

The drug is a strong antibiotic with a wide spectrum of antimicrobial activity. It has a detrimental effect against many types of pathogenic microbes.

Tsipromed stops the reproduction and growth of foreign bacteria that are not susceptible to other antibacterial agents. In addition, acting locally, the drug has low toxicity, it is quickly absorbed into the tissues of the organs of vision through the mucous membrane of the eyeball and begins to act actively 10 minutes after application.

The medicinal substance reaches its maximum concentration in the tissues after 2 hours. The effect of therapeutic exposure in the cornea of ​​the eyeball lasts about 6 hours, and in the anterior chamber of the eye - up to 4 hours. The remains of the antibiotic ciprofloxacin are excreted through the intestines and kidneys.

The drug is notable for the fact that when used simultaneously with other antibacterial drugs (with an interval of 20 minutes), it does not have a negative effect.

Indications and contraindications

Means Tsipromed is used to treat diseases of the organs of vision caused by pathogenic bacteria and to eliminate the consequences of surgery and mechanical injuries.

Tsipromed is prescribed in connection with:

• conjunctivitis in acute and subacute form;
• blepharitis, when the eyelid becomes inflamed;
• keratitis and mechanical trauma of the cornea;
• uveitis, disease of the choroid of the organs of vision;
• dactriocystitis and canaliculitis;
• barley (meibomite);
• iridocyclitis.

Tsipromed is also used to prevent complications of an infectious nature after operations and to remove foreign bodies from the eyeball.

When taking Tsipromed, it must be borne in mind that it has contraindications: it can adversely affect the health of the fetus and the well-being of the pregnant woman. It should not be used by women who are breastfeeding and babies under one year of age.

Patients using soft contact lenses should be aware that the Tsipromed preservative is adsorbed on contact lenses and impairs their quality. Before using the drug, hard lenses should be removed. It is recommended to put them on 20 minutes after the application of Tsipromed.

Dosage

Be sure to carefully read the instructions for the drug. The frequency of use is determined by the age of the patient and the type of disease. The drug is prescribed by ophthalmologists one or two drops into the problem eye.

When detecting bacterial conjunctivitis and treating blepharitis, instillation is done 4 to 8 times a day, but, as a rule, the peculiarity of the course of the disease of the organs of vision is taken into account. The course of treatment is usually prescribed in mild cases of the disease for 5 days, in more serious cases - up to 2 weeks.

Keratitis, when the cornea of ​​the eye becomes inflamed, requires 6 single prescriptions of the drug, one drop per day with a course duration of 2 to 4 weeks. With anterior uveitis and damage to the cornea of ​​\u200b\u200bthe eye with Pseudomonas aeruginosa, Tsipromed is used by instilling it one drop up to 12 times a day. This treatment with drops lasts 30 days.

In the treatment of the acute form of dacryocystitis, instillation is done from 6 to 12 times a day, and in the chronic form, from 4 to 8 times. As you know, the drug has proven itself as a prophylactic agent in the period after the operation performed in the organs of vision. Tsipromed should be used for the prevention of infections within 15 days, in which case it is prescribed 1 drop 8 times a day.

Eye drops Tsipromed for children

In the practice of eye doctors today there are no ophthalmic drugs used specifically only for children, which are safe for a fragile child's body.

Drops Tsipromed, belonging to the group of fluoroquinolones, for some time were not prescribed to children on the basis of experiments that indicated that they cause damage to the joints and bones.

But recently, after numerous studies in clinics, Tsipromed has been actively used in the treatment of infectious eye diseases in children.

The frequency of use of drops, as well as the dose, depends on the type of disease and the characteristics of its course:

1. Apply 2 drops of the drug 6 to 8 times for conjunctivitis and blepharitis. The duration of the course is 1-2 weeks.
2. With uveitis, a 3-week course is prescribed with instillation of 1 drop into the problem eye from 8 to 12 times a day.
3. For keratitis, use 1 drop in the affected eye 6 times a day. A course of treatment with a duration of 2 weeks is prescribed depending on the course of the disease. In more severe cases, therapy lasts one month.
4. The drug effectively acts as a preventive measure after surgery. It is prescribed 5 times a day, 1 drop for 30 days.

Tsipromed has an effective therapeutic effect in the treatment of barley in the eye. It is well tolerated by children.

The drug is contraindicated in relation to babies up to a year.

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All about adverse reactions

Like any remedy, Tsipromed is not without side effects.

Those who have hypersensitivity to the components of the drug may find signs of:

• skin rash, burning sensation and itching;
• urticaria;
• breathing problems.

An adverse reaction may occur in patients over the age of 65, since the use of drugs that contain corticosteroids causes tendon problems.

In rare cases, there is a manifestation of an adverse reaction in the form of:

• keratitis;
• photophobia;
• unpleasant taste in the mouth;
• infiltration of the cornea of ​​\u200b\u200bthe eye with the appearance of dark spots;
• allergies.

Some patients may experience decreased visual acuity. In such cases, after instillation of the drug, you should refrain from driving for several minutes.

If such side symptoms appear, you should refuse to use eye drops and consult an ophthalmologist.

Analogues of this drug

Among the drugs used to treat eye diseases, there are many drugs that act in the same way as Tsipromed.

The drug Oftakviks, produced by a Finnish company, acts against many pathogenic bacteria for 6 hours, penetrating into the cells. A positive result from the application is noted in a day.

In the first two days after the appointment, Oftaquix is ​​instilled 1-2 drops during the daytime every 2 hours into the diseased eye, bringing the total amount up to 8 times. Starting from the 3rd day, the dosage is left unchanged, but the frequency of instillation is reduced to 4 per day.


Floksal eye drops also have the same therapeutic effect as Tsipromed. Apply Floksal 1 drop in the diseased eye from 2 to 4 times a day with the appointment of a course of treatment for 2 weeks.

One of the antimicrobials Tobrex is suitable for all age groups, even infants. It is prescribed to take 1-2 drops with an interval of 4 hours in the problem eye for 7 to 10 days.

In severe cases, the drug is instilled 1-2 drops every hour until the inflammatory process decreases.

The therapeutic substance ciprofloxacin of antimicrobial action is present in the composition of many analogues of Tsipromed.

For example:

1. Cifloxinal is prescribed orally for ocular infectious diseases.
2. Cifran, Tsiprobay and Tsiprinol are used for ENT infections.

Ear drops for adults

Tsipromed is an effective drug that helps to get rid of inflammation of the ear caused by pathogenic bacteria.

Tsipromed is actively used:

• with an infection of the outer ear (otitis externa);
• acute and chronic forms of inflammation of the middle ear;
• with complications after operations;
• in order to protect against infection after an injury to the organ of hearing or surgery;
• when removing a foreign object from the ear, when the tissues of the hearing organ are damaged.

Tsipromed is also effective in detecting otitis media, when perforation of the eardrum occurs, and pus, breaking out of the ear, comes out.

The drug helps well with otitis media, which is provoked by the ingress of water into the outer or middle ear. When water lingers in the ear for a long time, the infection can enter through the ear canal and contribute to the development of the inflammatory process.

The drug Tsipromed is also successfully used by otorhinolaryngologists to prevent infection after surgical operations in the hearing organs. The doctor prescribes the dose of Tsipromed depending on the severity of the disease.

But patients who will use it on their own should know:

• 5 drops should be instilled into each ear three times a day;
• the course of treatment with ear drops should not last more than 10 days.

If the drug does not help in eliminating the disease, you should choose another remedy, after consulting with your doctor.

Tsipromed is contraindicated in patients with a fungal origin of the disease of the organ of hearing and tuberculosis of the ear. You can not assign it to children and women during childbearing.

Appointment for children with ear diseases

Pain in the hearing organs gives babies painful sensations, for the elimination of which doctors prescribe ear drops. Usually, children with weak immunity are exposed to infectious and inflammatory diseases of the ear in the summer, when the swimming season begins.

Ear injuries, thermal and chemical burns, as well as a long stay in a humid climate and frequent hygiene of the hearing organ can also provoke otitis media.

A factor for the development of otitis is the structural features of the organ of hearing, which favor the penetration of infection. Otitis causes itching and pain in the ear canal, with chewing and at night the pain intensifies.

One of the effective drugs against bacterial infections is Tsipromed, it is used not only for the treatment of diseases of the organ of hearing, but also for preventive purposes after operations.

The drug has a restriction in the appointment: it can not be used by children under 15 years of age. Adolescents from the age of 15 can be treated by instilling 5 drops into the inflamed ear three times a day.

Before using the ear drops, the outer part of the hearing aid must be thoroughly rinsed with warm water and dried. Drops should be heated, holding in the palms, to body temperature. Instillation of the drug is continued until the pain is eliminated.

When ear diseases are detected, one cannot self-medicate; an otolaryngologist should deal with their treatment.

The use of tablets by patients

Cipromed tablets with the active substance ciprofloxacin are an antimicrobial agent, a quinolone derivative. It acts against entero- and gram-negative bacteria, intracellular pathogens.

Tablets are taken orally, there is a rapid absorption of the drug (absorbability) and good distribution in tissues.

Indications for the use of Tsipromed tablets is the diagnosis of infectious diseases of the lower respiratory tract:

• pneumonia and bronchitis;
• diseases of the ENT organs.

The drug is also prescribed for:

• cystitis and pyelonephritis;
• gonorrhea and prostatitis;
• skin infections, septic arthritis, osteomyelitis.

Tablets have side effects that can be manifested by nausea, vomiting, flatulence, and from the side of the nervous system - headaches, insomnia, depression and nightmares.

Tsipromed refers to potent antibiotics.

Dosage form, composition

Tsipromed eye drops are a colorless (light yellow coloration is allowed) transparent liquid. The main active ingredient of the drug is ciprofloxacin, its content in 1 ml of drops is 3 mg.

Also, the composition of the drug includes auxiliary compounds, which include:

1. Sodium edetate.
2. Sodium chloride.
3. Lactic acid.
4. Sodium hydroxide.
5. Benzoalkonium chloride.
6. Water for injections.

Tsipromed eye drops are contained in a 5 ml dropper bottle. The cardboard pack includes one bottle of eye drops, as well as instructions for using the drug.

pharmachologic effect

Tsipromed eye drops contain ciprofloxacin, which is an antibacterial agent of the fluoroquinolone group. It has a bactericidal effect (leads to the death of bacteria), which is realized by suppressing the catalytic activity of the enzyme DNA gyrase in bacterial cells.

The result of the suppression of the activity of this enzyme is a violation of the replication process (doubling) of DNA, followed by the death of bacteria. The bactericidal effect of the drug is manifested both in relation to dividing bacterial cells and microorganisms that are at rest.

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Tsipromed drops are sold in bottles of 0.3% -5 ml. Ingredients: sodium chloride, ciprofloxocin, sodium edetate, benzalkonium chloride, distilled water, sodium hydroxide, lactic acid.

pharmachologic effect

Tsipromed is a broad-spectrum antimicrobial agent belonging to the group of fluoroquinolones. Active substance - ciprofloxocin(II generation). Ciprofloxacin disrupts the formation of bacterial DNA by inhibiting topoisomerase II, IV and DNA gyrase.

Pharmacokinetics

Penetrates into the tissue of the eye quickly. Antimicrobial action lasts 6 hours. The drug is used topically in the eyeballs, but the drug has a resorptive effect. Tsipromed may accumulate in the milk of nursing women. The elimination half-life is 5-6 hours. Tsipromed is excreted through the kidneys and intestines.

Indications for use

1. Infectious inflammation of the appendages of the eye ().
2. Infectious inflammation of the cornea (keratitis).
3. Infectious inflammation of the choroid (uveitis).
4. Eye ulcer of bacterial etiology.
5. (maybolite).
6. Inflammation of the lacrimal sac (chronic).
7. Infections that occur after foreign bodies or trauma enter the eye.
8. Prevention of bacterial infections before and after eye surgery.

Can it be given to children?

Tsipromed belongs to the group of fluoroquinolones, which not recommended for children based on experimental data. Oxolinic, pipemidic, nalidixic acids, which are part of the composition, disrupt the formation of bones and joints in children.

Fluoroquinolones are not recommended for use in adolescents. Treatment is carried out only when the life of the child is threatened, if there is no effect from the appointment of other antimicrobial agents (exacerbation of infection in cystic fibrosis; severe infections, sepsis, septicopyemia, septicococcemia, infections with a low content of neutrophils).

But recently, pediatric ophthalmologists have begun to deal with the resistance of infectious agents in children, frequent allergies to standard treatment. There is a trend towards an increase in the disease in the direction of gram-negative microorganisms, which have a more aggressive set of enzymes and high resistance to treatment, which forced us to take a fresh look at the tactics of treating bacterial eye infections in children.

After conducting research in many ophthalmological clinics of the drug, it was decided to start using Tsipromed in the practice of treating children. Tsipromed enters the bloodstream many times less than fluoroquinolones, which are administered orally or intramuscularly. As a result, side effects are very rare.

But women who are breastfeeding should not take the drug or stop breastfeeding at the time of taking it, since the drug violates the interarticular cartilage in infants and disrupts the further growth of the baby.

Instructions for use

Drops are instilled locally 1-2 drops in the inner corner of the eye. It is necessary to bury at a distance of 1-2 cm from the eye. The dose and frequency rate is determined individually, based on the disease and the severity of the course.

• With blepharitis, conjunctivitis, 2 drops are prescribed 6-8 times for 6-14 days.
• With keratitis, it is necessary to instill 1 drop into the infected eye 6 or more times over a period of 2 weeks to a month.
• with keratitis caused by Pseudomonas aeruginosa in the infected eye, 1 drop 8-12 times with a course of 2-3 weeks.
• For uveitis, 1 drop into the infected eye 8-12 times for 3 weeks.
• For the prevention of bacterial infections of the eye after surgery, 1 drop 5 times a day from 5 days to a month.
• For the prevention of bacterial infections after eye injuries, 1 drop 5-8 times 7-14 days.
• Cannot be given to infants because of the high risk of complications.

Side effects

• From the side of the system: digestion: nausea, vomiting, diarrhea, increased titer of liver enzymes: alkaline phosphatase, lactate dehydrogenase.
• From the nervous system: dizziness, insomnia, fainting.
• From the genitourinary system: urinary excretion of crystals, albumins, erythrocytes, hemoglobin, inflammation of the glomeruli of the nephron, impaired urination.
• From the hematopoietic side: an increase in eosinophils, a decrease in leukocytes, neutrophils.
• From the side of the heart: decreased pressure, increased heart rate, rhythm disturbance.
• Other: joint pain, allergies.

Contraindications

• Children up to a year.
• Pregnant and lactating mothers. Tsipromed passes through the placental barrier.
• People with hypersensitivity to the drug.

Analogues and price

In terms of pharmacological action and composition, drugs such as Quintor, Afenoxin, Ificipro, Ceprova, Ciprofloxacin, Lyproquin are similar. Levomycetin; Sulfacyl sodium; Tobropt; Phloxal.

Drug price: 120 - 210 rubles.

Tsipromed belongs to the second generation of fluoroquinolines. The main active ingredient here is ciprofloxacin hydrochloride. It is in these eye drops 3 mg per 1 ml.

In addition to ciprofloxacin, the eye drops also included benzalkonium chloride, edetate and sodium chloride, lactic acid, sodium hydroxide and purified water.
The drug is produced by pharmacological companies (India) in plastic bottles (droppers) of 5 ml, as well as in glass containers with a dropper tip (5 ml).

The price in Russian pharmacies for these eye drops is from 130 rubles.
The drug, like its analogues, is released by prescription.
In addition to drops, with this name there are eye ointment and ear drops.
This medicine has many analogues. Among its synonyms will be eye drops.

And these are just some of the analogue eye drops produced.

The rapid effect of the use of Tsipromed is due to the action of ciprofloxacin. It penetrates into all components of the eye during the first 10 minutes. The drug overcomes the membranes of bacterial cells and inhibits DNA gylase, disrupts the synthesis of bacterial DNA. A feature of ciprofloxicin is its high efficiency. It is effective in cases where bacteria are insensitive to aminoglycosides, cephalosporins, tetracyclines, penicillins and others (to all antibiotics that do not belong to the group of DNA gylase inhibitors).

The maximum result from topical application in ophthalmology lasts 2 hours, after which the concentration of ciprofloxacin in the cells begins to decrease, but the effect lasts up to 6 hours.

The main active ingredient of Tsipromed penetrates into the systemic circulation and breast milk, is excreted by the liver, intestines and kidneys.

The drug acts on gram-negative and gram-positive anaerobic bacteria, intracellular pathogens.
Most staphylococci are moderately resistant to the drug, which requires large doses of Tsipromed to suppress them.
A number of microorganisms (Pseudomonas cepacia, No-cardia asteroids, Clostridium difficile, Treponema pallidum) are resistant to this drug.

Often, the use of an antibiotic is preceded, in addition to an ophthalmological examination, by research on discharge from the eye. These measures are necessary to more accurately determine the type of bacteria, which, in turn, will quickly get rid of the unpleasant symptoms of the disease. The use of Tsipromed without consulting an ophthalmologist may be ineffective (if the bacteria are resistant to ciprofloxacin).

Among the eye problems in adults and children, in which ophthalmologists prescribe Tsipromed eye drops, there will be:

1. Inflammatory processes of the eye and its components.
   • Blepharitis.
   • Conjunctivitis.
   • Keratitis.
   • Anterior uveitis.
   • Bacterial corneal ulcer.
   • Meibonites.
   • Dacryocystitis.

   Provided that they are caused by bacteria sensitive to ciprofloxacin.

2. Preventive anti-infective measures in the pre- and postoperative period during surgery on the eye.
3. Antibacterial measures when a foreign body enters the eye or in case of eye injuries.

The course of treatment, as well as the prescription of the medicine itself, must be determined by the doctor. Particular attention should be paid to the dosage and frequency in the treatment of eye diseases with this antibiotic in children. Only a doctor can make an appointment here.

Usually with blepharitis and conjunctivitis, the frequency is 5-8 times a day for one to two weeks (but not less than 5 days).
With keratitis, the frequency of instillations is from 6 times a day and from 15 days to one month.
With damage to the cornea from 8 to 12 times a day for 15-21 days.
For prevention, it is prescribed 4-6 times a day, for 7-15 days.
In ophthalmic operations 5-6 times a day for a period of 5 days to 1 month.

Among the contraindications, the instructions for use describe the following cases.

• Tsipromed drops are not prescribed for existing allergic reactions to ciprofloxicin or other components of these eye drops.
• The drug is contraindicated in pregnant women.
• If it is necessary to treat a nursing woman with Tsipromed, breastfeeding should be interrupted.
• Eye drops are not used for children under 1 year old, and eye ointment up to 2 years old.

The appointment of drugs with a pH value of 3–4 prevents the use of Tsipromed for treatment. These drugs are pharmacologically incompatible.

With complex treatment with several types of eye drops and ointments, the time for instillation of Tsipromed (and all its analogues) should be delayed for at least 5 minutes.

Among the side effects caused by ciprofloxacin will be general and local effects.

• swelling and redness of the eyelid,
• the appearance of profuse lacrimation,
• photophobia,
• decreased visual acuity or clarity,
• formation of infiltration
• the appearance of spots on the cornea,
• burning sensation in the eye
• feeling of a foreign body.

• bad taste in the mouth,
• headache,
• distraction of attention
• allergic reactions.

If at least one of the listed manifestations occurs, instillation should be stopped and an ophthalmologist should be consulted.

The possibility of side effects (decreased visual acuity, absent-mindedness) requires delaying the management of transport or other complex mechanisms. This can be done only 20-30 minutes after the procedure, making sure that they are absent.

Special instructions for the use of Tsipromed.

1. The antibiotic should be used, observing all the rules of hygiene.
   • Wash your hands before the procedure.
   • Warm the medicine in your hand to a comfortable temperature.
   • Perform the procedure in a suitable room and in a comfortable position.
   • Drip the medicine into the conjunctival sac, slightly pulling the lower eyelid.
   • First drip the eye that is less affected.
   • Do not touch the pipette to the eye, or its components.
   • After instillation, immediately close the vial with a cap.
   • Strictly observe the dosage and frequency of instillation.

   This will avoid re-infection of the eye and speed up recovery.

2. Tsipromed is used only locally. The introduction of the drug injection is not recommended.
3. If wearing hard contact lenses, they should be removed before the procedure. You can dress only 15-20 minutes after instillation.
4. If the patient wears soft lenses, it is better for him not to prescribe Tsipromed. Preservatives of the drug will be deposited on the lens and may have a negative effect on the eye.
5. An open vial can be stored at room temperature for up to 30 days.

Heal and be healthy!

Eye diseases caused by injuries or having a bacterial origin can provoke very serious consequences, up to loss of vision. In order to avoid this, in modern ophthalmology, the drug "Tsipromed" (eye drops) is used. Instructions for this very effective and high-quality drug in a free presentation will be provided to the attention of the reader in today's article.

Eye drops "Tsipromed" is a sterile transparent solution, colorless or having a slight yellowish tint. It contains ciprofloxacin hydrochloride (at a concentration of 0.3%), benzahexonium hydrochloride, lactic acid, disodium salt, sodium chloride and hydroxide, and water for injection. The drug is produced in plastic dropper bottles or dark glass bottles equipped with a dropper, with a volume of 5 ml.

The described agent belongs to the group of fluoroquinolones and belongs to broad-spectrum antibiotics. The drug has bactericidal properties and is harmful to staphylococci, gonococci, streptococci, bacteroids, legionella, diphtheria corynebacteria, as well as other microorganisms, including strains resistant to other antibiotics. In addition, a distinctive feature of this substance is its low toxicity and rapid onset of action (after 10 minutes).

The instruction for drops claims that this drug has a wide field of action, therefore, many eye diseases can be treated with it:

• conjunctivitis in acute and subacute form;
• keratitis (inflammation of the cornea);
• iridocyclitis (disease of the iris);
• inflammation of the eyelids (blepharitis);
• uveitis (inflammation of the vascular membrane of the eye);
• dacryocystitis (impaired patency of the nasolacrimal duct).

In addition, the drug is used to prevent and treat complications after eye surgery or injuries to the organs of vision.

The named agent is well absorbed into the tissues of the eye through the conjunctiva (mucosa). The maximum active substance is concentrated in the tissues one hour after instillation, after two hours its amount begins to decrease. The antibacterial effect persists in the cornea for about six hours, and in the fluid that fills the anterior chamber of the eye - up to four hours.

Eye drops, the instructions for which are provided to your attention, can cause slight tingling, redness of the eye and itching after use, which last no more than two minutes. The eye is watery, and sometimes a bitter taste appears in the mouth. The use of drops also causes allergic reactions to the components of this drug. Occasionally, it provokes a weakening of vision, inflammation of the cornea and its infiltration. And long-term use of this drug in some patients causes the development of superinfection. Remember that if unpleasant symptoms appear after instillation, it is necessary to stop treatment with eye drops and consult a doctor immediately!

The frequency of use of Tsipromed eye drops, the instructions for which are proposed in this article, depends on the type of disease and the age of the patient. As a rule, the named drug is prescribed one or two drops in the affected eye.

• Bacterial conjunctivitis and blepharitis require instillation 4 to 8 times a day, depending on the course of the disease. The course of treatment is usually from five days to two weeks.
• With keratitis, the drug is prescribed drop by drop at least six times a day for 2-4 weeks.
• Anterior uveitis and corneal lesions require more frequent daily use - up to 12 times (as a rule, recovery occurs no later than a month).
• Acute dacryocystitis is treated with instillation six to twelve times a day, and chronic - 4-8 times.
• As a prophylaxis of inflammation in the postoperative period, eye drops are used 1 drop up to 8 times / day. no more than two weeks.

With external use of the described agent, an overdose was not observed. And accidental ingestion of Tsipromed eye drops can be hazardous to health, although there are no specific signs of poisoning. As a rule, headache, nausea accompanied by vomiting, diarrhea, and sometimes feelings of anxiety and fainting can occur. Assistance to the victim is standard: cleansing the stomach and providing a sufficient volume of fluid. It is also necessary to create an acidic urine reaction to prevent the appearance of salt crystals in it (the so-called crystalluria).

During lactation, this drug can only be used by stopping feeding, since the active substance of the eye drops penetrates into breast milk. Here are some more tips:

• do not use contact lenses within 20 minutes after instillation if you are prescribed this drug, because its components penetrate the structure of the lenses and may adversely affect the condition of the eye;
• when prescribing complex treatment with other drugs, it is necessary to observe an interval of five minutes between their use.
• please note that Tsipromed eye drops are contraindicated for pregnant women and children under one year old;
• Once opened, the vial should be used within a month.

Eye drops "Tsipromed" are not combined with some drugs. They should not be used when prescribing antacids, antiarrhythmic drugs, and together with antidepressants.

In pediatric practice today, there are practically no children's ophthalmic antibacterial drugs that are safe for use between the ages of one and up to 15 years. Therefore, the fact that the described drops were officially approved for the treatment of children of this age group aroused enthusiasm among pediatric ophthalmologists. Both doctors and parents leave reviews about the use of Tsipromed drops, emphasizing their effectiveness in the treatment of inflammatory diseases of the conjunctiva and affordability.

In order for the results of treatment with the proposed remedy to be more tangible, parents are required to comply with the dosage and frequency of instillations suggested by the doctor. The treatment process should look like this:

• re-read the instructions for the use of drops;
• wash your hands thoroughly;
• warn the child that the droplets “pinch” a little;
• wipe the baby's eyes with a cotton swab;
• shake the bottle with drops;
• lay the child on his back so that his head is slightly thrown back (have someone hold him in one position);
• gently pull the baby's lower eyelid;
• squeeze a drop of medicine onto it without touching the eye;
• release the eyelid, and let the child blink so that the product is evenly distributed;
• wipe off the remaining drops with a clean cloth.

For those who are thinking about whether to use the drug "Tsipromed" (eye drops), the instruction should not be the last push to start treatment. Be sure to ask your doctor for advice! Do not forget that you have an antibiotic in front of you, which means that its thoughtless use can be harmful to your health!

Compound

The composition of ear and eye drops Tsipromed differs in the form of the active substance and auxiliary ingredients.

Tsipromed eye drops per 1 ml of medicine contain 3 mg ciprofloxacin in the form of hydrochloride. Drops in the ears are released with the same percentage (3%) of the active substance, but lactate is used.

Auxiliary substances in the composition of eye drops:

• benzalkonium chloride;
• edetet sodium;
• lactic acid;
• sodium chloride;
• sodium hydroxide;
• water for injections.

Additional ingredients contained in ear drops:

• benzalkonium chloride;
• propylene glycol;
• lactic acid.

The drug is available in two forms:

• Eye drops. Clear solution, colorless or pale yellow. They sell 5 ml in plastic dropper bottles or dark glass bottles, each of them must be in a separate cardboard box. Complete with glass bottles, a special dropper is released.
• Ear drops Tsipromed- transparent, viscous liquid, colorless or with a slight yellowish tint. Poured into 10 ml bottles made of dark glass or plastic dropper bottles. 1 vial is placed in cardboard packs.

Refers to antibacterial preparations for topical use.

Pharmacodynamics

Belongs to a group fluoroquinolones. The drug acts on most gram-negative bacteria and some gram-positive. Tsipromed refers to low-toxic substances for humans.

The active substance of the drug inhibits the action enzyme DNA gyrase, which is necessary for the implementation of DNA replication of these microorganisms and the synthesis of proteins in a bacterial cell. All bacteria are affected by the drug, regardless of the stage of development they are in.

Systemic absorption of ear drops is low, so studies of the pharmacokinetic properties of this form of the drug have not been conducted.

Tsipromed eye drops penetrate well into all tissues of the eye and enter the systemic circulation. The maximum concentration in the anterior chamber of the eye is reached one hour after instillation, decreases after another hour. The half-life of blood plasma– 4-5 hours. Excretion from the body is carried out by the kidneys (50% - unchanged drug, 10% - metabolites) and intestines (15%). May be found in breast milk.

Indications for the use of eye drops:

• acute and subacute forms conjunctivitis;
• keratitis;
• uveitis anterior chamber;
• inflammatory processes in the eyelids, for example, blepharitis;
• dacryocystitis;
• the need to prevent the development of the inflammatory process after injuries or operations performed in the eye area.

Ear drops Tsipromed are prescribed for the treatment or prevention of infectious diseases affecting the ear:

• at otitis externa;
• at otitis media(acute and chronic form);
• before and after surgery;
• with an ear injury;
• in case of tissue damage during the extraction of a foreign body.

Tsipromed can not be prescribed:

• pregnant women;
• breastfeeding women;
• children who are not yet 1 year old;
• with intolerance to fluoroquinolones;
• with hypersensitivity to one or more components that make up the drug.

Ear drops should not be used by persons under the age of 16.

Possible allergic reaction to the components of the drug. It may also occur nausea, urge to vomit, stool disorders, headache or dizziness, sense of anxiety.

When instilled into the eyes, the development of local undesirable effects is possible:

• slight burning during the first minute;
• sensation itching or soreness;
• redness of the eye;
• edema in the area of ​​the eyelids;
• photophobia;
• increased secretion of tear fluid;
• feeling as if something is in the eye;
• white crystal precipitate(in the presence of a corneal ulcer);
• blurred vision;
• keratitis or keratopathy.

Instructions for eye drops Tsipromed

The medicine is instilled into the conjunctival sac, 1 or 2 drops. How often this should be done depends on the diagnosis.

Features of Tsipromed treatment of various eye diseases:

• acute bacterial conjunctivitis, blepharitis- from 4 to 8 times a day for 5-14 days;
• keratitis- 1 drop 6 or more times a day, treatment lasts from 2 weeks to a month;
• front uveitis- 1 drop 8-12 times a day;
• sharp dacryocystitis, canaliculitis- 6-12 times, chronic forms of these diseases - 4-8 times;
• after an injury - 4-8 times a day, the course lasts 1 or 2 weeks;
• after surgery - 4-6 times; depending on the severity of the surgical intervention, the duration of the drug can be from 5 days to a month.

Ear drops Tsipromed, instructions for use

Must be cleaned before instillation. Drops are heated to body temperature.

5 drops are dripped into the ear 3 times every day until the symptoms of inflammation disappear and another 48 hours.

After the medicine has been instilled, you need to tilt your head back for 2 minutes. If possible, the external auditory meatus is closed with a cotton turunda.

With local application of cases of overdose was not observed.

Overdose symptoms when taking the drug inside:

• feeling nausea and vomiting;
• diarrhea;
• headache;
• dizziness;
• fainting;
• sense of anxiety.

Symptomatic treatment with the use of a large amount of liquid is shown. Medications that increase the acidity of the urine may be prescribed to prevent crystalluria.

Cannot be combined with solutions in which pH = 3-4.

Sold by prescription.

Store at room temperature, avoid freezing.

2 years, but not more than 1 year after opening the vial.

Contact lens wearers should avoid contact with drops.

Immediately after instillation of the eyes, visual acuity may decrease for some time, so at this time it is undesirable to drive a vehicle or engage in any activity that requires increased attention.

Ear drops are prohibited up to 16 years, eye drops - up to a year.

A doctor may prescribe eye drops for a child's nose, even if they are less than a year old. This measure is often resorted to when the discharge from the sinuses becomes greenish, which indicates a bacterial infection.

Application is prohibited.

Tsipromed's analogs:

• Apox;
• Floximed;
• ciloxane;
• Ciproxol;
• Tsiprolet;
• Cypronex;
• Ciprofarm;
• Ciprofloxacin.

Ear drops Tsipromed, reviews

The tool is effective in fighting infection, but sometimes pain in the ear increases with use. Among the shortcomings are the large volume of the bottle. Since the shelf life is short, part of the purchased medicine has to be thrown away unused.

Tsipromed is an antimicrobial agent, fluoroquinolone.

Release form and composition

• ear drops: a clear, colorless or light yellow liquid (10 ml of solution in a plastic or dark glass bottle, 1 bottle in a cardboard box);
• eye drops: a clear, colorless or light yellow liquid (5 ml solution in a plastic or dark glass bottle, 1 bottle in a cardboard box).

Composition of 1 ml ear drops:

• active substance: ciprofloxacin lactate - 3 mg;
• auxiliary components: benzalkonium chloride, lactic acid, propylene glycol.

Composition of 1 ml eye drops:

• active substance: ciprofloxacin hydrochloride (in terms of ciprofloxacin) - 3 mg;
• auxiliary components: benzalkonium chloride, lactic acid, disodium edetate, sodium chloride, sodium hydroxide, water for injection.

Indications for use

Ear drops

Chronic and acute ear diseases caused by microorganisms sensitive to ciprofloxacin:

• otitis externa (inflammation of the external auditory canal);
• chronic and acute otitis media;
• infectious inflammation of the Eustachian tube and otitis media;
• prevention of infectious otitis in ear injuries, surgical interventions, extraction of a foreign object from the external auditory canal, accompanied by damage to the ear tissues.

Eye drops

Bacterial inflammatory diseases of the eye and its appendages:

• conjunctivitis (acute and subacute);
• blepharitis and other inflammatory diseases of the eyelids;
• dacryocystitis;
• anterior uveitis;
• keratitis;
• prevention and treatment of infectious complications during surgical interventions on the eyeball, as well as after traumatic injuries of the eye and its appendages.

Contraindications

• hypersensitivity to any component of the drug, as well as to other quinolones;
• pregnancy and lactation;
• age up to 15 years (for ear drops), up to 1 year (for eye drops).

Method of application and dosage

Ear drops

Adults instill warm (body temperature) drops of 5 drops into the ear 3 times a day, after washing and draining the external auditory canal. Drops are instilled lying on your side or with your head thrown back. After instillation, to let the drops drain into the ear canal, you should pull the earlobe down and back. You can place a cotton turunda in the ear canal.

The use of the drug should be continued for 48 hours after the disappearance of the symptoms of the disease or as directed by the doctor.

Eye drops

Tsipromed is instilled 1-2 drops into the conjunctival sac. The number of installations depends on the severity of the disease.

• acute bacterial conjunctivitis, blepharitis (simple, scaly, ulcerative): 4-8 times a day for 5-14 days;
• keratitis: 1 drop at least 6 times a day for 2-4 weeks (if there is a positive result);
• Pseudomonas aeruginosa (with corneal lesions): 1 drop at least 8-12 times a day for 2-3 weeks;
• anterior uveitis: 1 drop 8-12 times a day;
• acute dacryocystitis, canaliculitis: 1 drop 6-12 times a day;
• chronic dacryocystitis, canaliculitis: 1 drop 4-8 times a day;
• prevention of secondary infection, injury to the eye and its appendages: 4-8 times a day for 1-2 weeks;
• prevention of complications after operations with perforation of the eyeball: 1 drop 4-6 times a day, the duration of therapy is from 5 days to 1 month.

Side effects

Ear drops

• allergic reactions;
• soreness (mild) and hyperemia of the tympanic membrane.

Eye drops

• allergic reactions;
• swelling of the eyelids;
• a slight burning sensation within 1-2 minutes after instillation;
• photophobia;
• keratopathy;
• sensation of a foreign body in the eyes;
• keratitis;
• lacrimation;
• itching, soreness, hyperemia of the mucous membrane of the eye;
• decreased visual acuity;
• the appearance of a white crystalline precipitate (with a corneal ulcer);
• the appearance of spots or infiltration of the cornea;
• unpleasant taste in the mouth (immediately after installation);
• development of superinfection.

Overdose

When taking the drug inside, headache, dizziness, anxiety, nausea, vomiting, diarrhea are possible.

Treatment: it is necessary to take emergency measures, ensure sufficient fluid intake, as well as the creation of an acidic urine reaction to prevent crystalluria.

There are no data on overdose with topical use of the drug.

special instructions

Eye drops

Do not use Tsipromed in the form of eye drops for patients wearing soft contact lenses, as the preservative may be deposited in them and have an undesirable effect on the tissues of the eye. Rigid contact lenses must be removed before instillation and not worn for 15 minutes after it. If it is necessary to use other ophthalmic solutions, the interval between their installations should be at least 5 minutes.

Care should be taken when driving vehicles and other complex mechanisms during the period of application of this form of Tsipromed.

drug interaction

Tsipromed is incompatible with drugs with a pH value of 3-4, which are physically or chemically unstable.

Analogues

Tsipromed's analogues are Basigen, Betaciprol, Vero-ciprofloxacin, Ificipro, Quintor, Nircipe, Oftocypro, Rocip, Protsipro, Tseprova, Tsiprinol, Tsiprobay, Tsiprodox, Tsiprolet, Tsiprolaker, Tsiprolon, Ciprofloxacin, Tsifran, Ecotsifol.

Terms and conditions of storage

Store away from light, at a temperature not exceeding 25 °C. Keep away from children. Do not freeze the drug.

Shelf life:

• ear drops - 3 years, after opening, store 45 days;
• eye drops - 2 years, after opening, store 1 month.

Terms of dispensing from pharmacies

Released by prescription.

The price of Tsipromed in pharmacies

The price of Tsipromed is about 132 rubles (eye drops) and 158 rubles (ear drops).

Compound

Description of the dosage form

Clear, colorless to pale yellow solution.

pharmachologic effect

Pharmacodynamics

An antibacterial drug from the group of fluoroquinolones. The drug inhibits the enzyme DNA gyrase of bacteria, as a result of which DNA replication and the synthesis of cellular proteins of bacteria are disrupted. It acts both on multiplying microorganisms and on those at rest, has a bactericidal effect.

The spectrum of antibacterial action of ciprofloxacin includes gram-negative microorganisms: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp.(indole positive and indole negative), Morganella morganii, Citrobacter spp., Klebsiella spp., Enterobacter spp., Yersinia spp., Vibrio spp., Campylobacter spp., Hafnia spp., Providencia stuartii, Haemophilus influenzae, Pasteurella multocida, Pseudomonas spp., Gardnerella spp. , Neisseria spp., Moraxella catarrhalis, Acinetobacter spp., Brucella spp., Chlamydia spp.

Gram-positive microorganisms are also sensitive to ciprofloxacin: Staphilococcus spp., Streptococcus pyogenes, St. agalactiae, Corynebacterium diphtheriae, Listeria monocitogenes. The drug has low toxicity.

Pharmacokinetics

Ciprofloxacin, when applied topically, penetrates well into the tissues of the eye. After a single instillation, its concentration in the moisture of the anterior chamber of the eye after 10 minutes is 0.1 mg/ml. C max , determined after 1 hour in the moisture of the anterior chamber, is 0.19 mg/ml. After 2 hours, the concentration begins to decrease, however, the antibacterial effect in the tissues of the cornea lasts up to 6 hours, in the moisture of the anterior chamber - up to 4 hours. T 1/2 from blood serum with topical application of eye drops is 4-5 hours. The drug is excreted through the kidneys , mainly (up to 50%) unchanged, up to 10% - in the form of metabolites, about 15% is excreted through the intestines, in breastfeeding mothers - partially excreted in breast milk.

After instillation, systemic absorption of the drug is possible. When treated for 7 days and instilled, on average, 4 times a day in both eyes, the average concentration is less than 2 ng / ml.

Indications of the drug Tsipromed

Bacterial inflammatory diseases of the eye and its appendages:

acute and subacute conjunctivitis;

anterior uveitis;

blepharitis and other inflammatory diseases of the eyelids;

dacryocystitis;

prevention and treatment of infectious complications after injuries of the eye and its appendages and during operations on the eyeball.

Contraindications

hypersensitivity to the components of the drug or other quinolones;

pregnancy;

breastfeeding period;

children's age up to 1 year.

Use during pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects

Sensation of a slight burning sensation within 1-2 minutes (immediately after instillation); itching, soreness, hyperemia of the mucous membrane of the eye, allergic reactions, swelling of the eyelids, photophobia, lacrimation, sensation of a foreign body in the eyes, an unpleasant aftertaste in the mouth immediately after instillation, decreased visual acuity, the appearance of a white crystalline precipitate in patients with a corneal ulcer, keratitis, keratopathy , the appearance of spots or infiltration of the cornea, the development of superinfection.

Interaction

Ciprofloxacin solution is incompatible with drug solutions with a pH value of 3-4, which are physically or chemically unstable.

Dosage and administration

locally.

Instill 1-2 drops into the conjunctival sac. The frequency of instillations depends on the severity of the inflammatory process.

In acute bacterial conjunctivitis, simple, scaly and ulcerative blepharitis - from 4 to 8 times a day, depending on the severity of the disease. The course of treatment is from 5 to 14 days.

With keratitis - 1 drop at least 6 times a day, if there is a positive effect, the maximum course of treatment, depending on the severity of the cornea lesion, is 2-4 weeks.

When the cornea is affected by Pseudomonas aeruginosa, it is prescribed as often as possible - at least 8-12 times a day, 1 drop. The course of treatment depends on the course of the disease and is usually about 2-3 weeks.

With anterior uveitis - 8-12 times a day, 1 drop.

In acute dacryocystitis and canaliculitis - 6-12 times a day, in chronic - 4-8 times 1 drop.

In case of injuries of the eye and its appendages for the prevention of secondary infection - for 1-2 weeks, 1 drop 4-8 times a day.

For the prevention of inflammatory diseases after surgical interventions with opening the eyeball - 4-6 times a day during the entire postoperative period, usually from 5 days to 1 month.

Overdose

Symptoms: in case of accidental ingestion, there are no specific symptoms; possible nausea, vomiting, diarrhea, headache, fainting, anxiety.

Treatment: usual emergency measures; sufficient fluid intake in the body, creating an acidic urine reaction to prevent crystalluria.

special instructions

If the patient wears soft contact lenses, then he should not use Tsipromed, because. The preservative can be deposited in soft contact lenses and have an adverse effect on the tissues of the eye.

Hard contact lenses should be removed before instillation of the drug and put on again only after 15 minutes.

When using other ophthalmic drugs, the interval between their administration should be at least 5 minutes.

Immediately after instillation of the drug, a decrease in the clarity of vision and a slowdown in mental reactions may occur, which may reduce the ability to actively participate in traffic, maintain machines or perform work without support. To an even greater extent, this occurs with the simultaneous use of the drug with alcohol.

Release form

Eye drops, 0.3%. 5 ml in a plastic dropper bottle with a screw cap. Each dropper bottle is placed in a cardboard box.

5 ml in a dark glass bottle, closed with a rubber stopper, crimped with an aluminum cap with a safety plastic cap. One glass vial with a sterile dropper packed in a PE bag is placed in a cardboard box.

Manufacturer

Promed Exports Pvt. Ltd., India.

212/D-1, Green Park, New Delhi, India.

Claim address

Representation of Promed Exports Pvt. Ltd. in Russia

111033, Moscow, Zolotorozhsky Val, 11, building 21.

Tel.: 229-76-63, fax: 229-76-64.

Terms of dispensing from pharmacies

On prescription.

Storage conditions of the drug Tsipromed

Keep out of the reach of children.

Shelf life of the drug Tsipromed

eye drops 0.3% - 2 years.

Do not use after the expiry date stated on the packaging.

Synonyms of nosological groups