Nicotinic acid for oral administration. Nicotinic acid (injections) - what is it prescribed for, and how to use the drug correctly? Characteristics of the substance Nicotinic acid

One milliliter of a 0.1% solution for injection contains 10 mg of the active substance, as well as sodium bicarbonate and water for injection.

In the State Pharmacopoeia of the USSR, X edition, it is indicated that the solution is a clear, colorless liquid with a pH of 5.0 to 7.0.

The concentration of nicotinic acid in one tablet is 0.05 grams.

Release form

Pharmacological forms of nicotinic acid: 1% injection solution and 50 mg tablets.

Ampoules with 1 ml of solution are packaged in 10 pieces in blister packs, 5 packs in a pack.

Tablets are sold packaged:

50 pieces in jars made of polymeric materials or dark glass;
10 pieces in blisters, 5 packs in a pack.

pharmachologic effect

Vitamin B. Compensates for the lack vitamin PP (B3), renders vasodilator (vasodilating), hypocholesterolemic and hypolipidemic action.

Pharmacodynamics and pharmacokinetics

Vitamin PP(nicotinic acid) is a vitamin that takes part in a large number of oxidative reactions occurring in living cells.

The drug has specific antipellagric action and used to improve performance blood vessels.

The appointment of nicotinic acid preparations allows you to normalize the permeability of the vascular walls and, accordingly, reduce the swelling of the tissue, improve the state of tissue (in particular, nitrogen and carbohydrate) metabolism and microcirculation, expand the lumen of the vessels (the vasodilating effect is noted at the level of small blood vessels, including those of the brain). brain), increase the fibrinolytic activity of blood plasma and reduce platelet aggregation by suppressing the synthesis of TxAj (thromboxane A2) - a mediator of their aggregation and degranulation.

In the body vitamin PP biotransformed into nicotinamide, which binds to the hydrogen-carrying coenzymes NAD and NADP. Regulates oxidation-reduction reactions, takes part in synthetic processes, amino acid metabolism, fat, purines, proteins, as well as in glycogenesis and tissue respiration.

Reduces the rate of VLDL synthesis and inhibits lipolysis(fat degradation) in adipose tissue. Contributes to the normalization of blood lipid composition: reduces the concentration of LDL, triglycerides and total cholesterol while increasing blood levels of HDL. Manifests antiatherogenic and detoxifying properties.

Provides the transformation of the trans-form of retinol into cis-retinal, which is used in the synthesis of the visual pigment rhodopsin, stimulates the release of histamine and promotes the activation of kininogenesis.

Vitamin B3 well absorbed into pylorus of the stomach and upper duodenum. Starring pyridoxine and riboflavin can be produced by the intestinal bacterial flora tryptophan that comes with food. The amount required to form a milligram of a substance tryptophan- 60 mg.

Metabolism occurs in the liver. Nicotinic acid and its metabolic products are excreted by the kidneys; when taken in high doses, the substance is excreted mainly in its pure form.

Indications for use

Indications for the use of nicotinic acid are:

hypo- and avitaminosis due to inadequate intake vitamin B3 with food, exclusively parenteral nutrition, malabsorption syndrome(including against the background of violations of work pancreas), Hartnup disease, rapid weight loss, gastrectomy, diseases of the digestive system ( persistent diarrhea, including tropical, celiac disease, Crohn's disease);
conditions with an increased need for vitamin PP(diseases of the hepatobiliary system, prolonged fever, hyperthyroidism, prolonged stress, chronic infections, pregnancy, lactation, cancer);
hyperlipidemia(including triglyceridemia and hypercholesterolemia);
atherosclerosis;
obliterating diseases of the vessels of the lower extremities (for example, Raynaud's disease);
ischemic circulatory disorders of the brain;
spasm of the urinary and biliary tract, vessels of the extremities;
microangiopathy;
diabetic polyneuropathy;
hypoacid gastritis;
colitis and enterocolitis;
neuropathy of the facial nerve;
trophic ulcers and non-healing wounds.

Contraindications

Categorical contraindications for both dosage forms of the drug are serious violations of liver function, bleeding, cerebral hemorrhage, hypersensitivity to nicotinic acid.

Nicotinic acid tablets should also not be taken during periods of exacerbation. peptic ulcer and children under 2 years of age (as anti-sclerotic agent).

Additional contraindications to the appointment of Nicotinic acid in ampoules are: atherosclerosis, hyperuricemia, severe arterial hypertension, gout, childhood.

Side effects

The drug stimulates the release histamine, which in some cases may be accompanied by:

reddening of the skin (mainly the upper half of the body and face) with a burning sensation and tingling;
hypotension;
orthostatic hypotension(with rapid introduction into a vein);
increased secretion of gastric juice;
dyspepsia;
dizziness;
sensation of a rush of blood to the head;
hives;
itching.

Side effects associated with long-term use of high doses vitamin B3, are expressed as:

anorexia;
dysfunction and fatty liver;
vomiting;
diarrhea;
irritation of the mucous membrane of the digestive canal;
ulceration (ulceration) of the gastric mucosa;
transient increase in the activity of alkaline phosphatase, aspartate aminotransferase, lactate dehydrogenase;
paresthesia;
arrhythmias;
decreased glucose tolerance;
hyperglycemia.

Application instruction of Nicotinic acid

Nicotinic acid injections: instructions for use

The route of administration and dose depend on the indication. At ischemic stroke and pellagra the solution is recommended to be slowly injected into a vein. At pellagra it is also allowed to give injections intramuscularly or subcutaneously.

Antipellagric therapy involves a single or double administration of 50 mg intravenously or 100 mg intramuscularly. The duration of treatment is 10-15 days.

At ischemic stroke the drug is administered in a dose ranging from 10 to 50 mg.

Injections are allowed to be placed in three ways:

1 ml of a 1% solution into the muscle;
intradermally (to fill the need for a vitamin);
in a vein, 1-5 ml of a 1% solution, previously diluted in 5 ml of saline.

V / m and s / c injections of the drug are quite painful and may be accompanied by a burning sensation. Intravenous injection may cause reddening of the skin and a sensation of heat.

This reaction of the body is normal. On the contrary, the absence of redness may indicate the presence of certain problems with blood circulation.

Instructions for tablets

Tablets are taken after meals.

The prophylactic dose for adults varies from 12.5 to 25 mg per day, for children - from 5 to 25 mg per day.

At pellagra adult patients are prescribed to take 100 mg of nicotinic acid 2 to 4 times a day. The duration of the course is 2-3 weeks. For children, the drug is given at 12.5-50 mg two or three times a day.

With vascular lesions atherosclerotic genesis patients are recommended to take in 2-4 doses from 2 to 3 grams vitamin PP.

Starting dose at dyslipidemia- 50 mg per day in one dose. Subsequently, if the therapy does not provoke adverse reactions, the frequency of applications is increased up to 2-3 times a day. The duration of the course is from one month. Intervals should be maintained between repeated courses.

In all other cases, the daily dose for adults is from 20 to 50, for children - from 12.5 to 25 mg. In some cases, for an adult patient, the doctor may increase the daily dose to 100 mg. Tablets, depending on the indications, are drunk 2 or 3 times a day.

Overdose

High doses of the drug can cause a rush of blood to the upper body and head, indigestion and itching.

In case of overdose, supportive treatment is indicated.

Interaction

N. acid enhances the action vasoactive drugs(in particular, ganglionic blockers), which may be accompanied by seizures orthostatic hypotension.

Bile acid sequestrants (eg. colestipol or cholestyramine) reduce the bioavailability of acidic drugs, including n. acid, so the drug should be taken at least one hour before or no earlier than four hours after taking these drugs.

When conducting an analysis to determine the level of glucose in the urine, the drug may provoke a false positive reaction with Benedict's reagent (copper sulfate solution).

N. acid has a hyperglycemic potential and can significantly reduce the activity of acarbose, which can cause decompensation diabetes.

Due to the ability of Mr. acid cause hyperglycemia, in patients who are prescribed the drug in combination with “ metformin + saxagliptin” or “metformin + sitagliptin”, you should constantly monitor the parameters of glycemic control.

In patients taking nadroparin calcium, it is necessary to control the indicators of hemocoagulation.

With the simultaneous use of n. acids and combinations amlodipine + atorvastatin”, n. acids and simvastatin, n. acids and lovastatin may increase the risk of developing myopathies. Combination n. acids with simvastatin can also provoke rhabdomyolysis.

Myopathy and rhabdomyolysis are also possible in the case of using the combination “n. acid in lipid-lowering doses and Simvastatin+ ezetimibe”.

Development risk myopathies also increases with the appointment of lipid-lowering (exceeding 1 gram per day) doses of n. acids in combination with Rosuvastatin. For this reason, treatment Rosuvastatin should start with 5 mg/day.

The combination of “nicotine + Vitamin C” should be used with caution.

The possibility of drug interaction with sodium heparin.

High doses n. acids reduce the effectiveness of the combination “ Glibenclamide+ Metformin”, hypoglycemic effect Gliclazide and the effectiveness of the combination “ Gliclazide + Metformin”, as well as hypoglycemic effect Glimepiride.

When used simultaneously with n. acid reduces the effect:

Glipizide;
hypoglycemic effect Gliquidona;
Insulina Lizpro(including two-phase);
Metformin;
repaglinide;
hypnotic effect Phenobarbital.

Do not mix in one syringe. acid and Thiamine.

Despite the fact that the simultaneous use of n. acids with HMG-CoA reductase inhibitors can provoke myopathy while co-administering the drug with Fluvastatin the bioavailability of the latter, as well as the bioavailability of n. acid, does not change. However, this combination should be used with caution.

Terms of sale

On prescription.

Recipe in Latin for the injectable form of the drug:
Nicotinic acid - ampoules
Rep: Sol. Acidi nicotinici 1% - 1 ml
D.t. d. N 20 ampull.
S. 1 ml / m.

Recipe in Latin for the tablet form of the drug:
Rep: Tab. Acidi nicotinici 0.05 g
D.t. d. No. 20 in tab.
S. 2 tablets 3 times a day after meals (with pellagra).

Storage conditions

Store at room temperature in a well-closed container, protected from sunlight. Keep away from children.

Best before date

For solution - 5 years. For tablets - 4 years.

special instructions

What is vitamin PP?

Wikipedia answers the question “what is nicotinic acid” that it is a white powdery substance, odorless and slightly sour in taste. The powder is poorly soluble in cold water, ethanol, ether and slightly better in hot water.

The gross formula of the substance is C₆H₅NO₂. It was first obtained in 1867 by oxidizing nicotine with H2CrO4 (chromic acid).

The benefits and harms of vitamin B3

Clean vitamin B3 able to enhance immunity so much so that the human body acquires natural protection against Staphylococcus aureus and a number of other equally serious viruses.

Scientists are confident that very high doses can stop even HIV infection and bacterial infection, against which most of the existing drugs are powerless.

Besides, vitamin B3 has properties detoxifier.

The body of an adult male requires 16 to 28 mg daily. vitamin B3, the body of a woman - from 14 to 20 mg.

The need for a vitamin will increase with intense nervous and mental activity, increased physical exertion, in people working in a hot shop, in a hot climate and in the Far North, during pregnancy and during breastfeeding, in people in whose diet vegetable proteins predominate over animals (including fasting people and people on a low-protein diet).

Nicotinic acid is necessary for the release of energy from fats and carbohydrates, as well as for the normal course of protein metabolism. It normalizes the functioning of the pancreas and stomach, and is also part of the enzymes that provide cellular respiration.

Vitamin has a beneficial effect on the heart, blood vessels, nervous system, maintains healthy mucous membranes of the oral cavity and intestines, skin; takes part in ensuring normal vision, reduces high blood pressure and improves blood circulation.

The lack of this substance in the body is accompanied by apathy, lethargy, fatigue, headaches, dizziness, dryness and pallor of the skin, insomnia, irritability, decreased appetite and body weight, constipation, palpitations, decreased resistance to infections.

If a person receives less nicotinic acid, he develops a disease pellagra. The first signs of the disease are:

frequent, watery stools (3 or more times a day, without impurities of blood and mucus);
poor appetite, heaviness in the stomach;
belching and heartburn;
redness of the oral mucosa;
salivation, burning in the mouth;
swelling and cracking of the lips;
protrusion of the papillae of the tongue with red dots;
the appearance of deep cracks in the tongue and red spots on the face, hands, elbows and neck;
swelling of the skin (the code may hurt, itch, blisters appear on it);
noise in ears;
severe weakness;
headache;
a feeling of crawling and numbness;
pressure fluctuations;
wobbly gait.

An excess of the vitamin, in turn, can cause skin rashes, itching and fainting.

Foods Containing Vitamin B3

To warn hypovitaminosis RR, it is preferable to adjust the diet so that the diet contains vitamin B3 containing products.

Where is nicotinic acid found? Most of the products vitamin B3 can be found in liver, egg yolk, yeast, nuts, fish, milk, chicken, green vegetables, meat, legumes, peanuts, buckwheat and any other food containing α-amino acid tryptophan.

Heat treatment does not affect the amount of vitamin.

Why is nicotinic acid needed in cosmetology?

The rejuvenating effect of the drug is based on the ability of nicotinic acid to dilate blood vessels in the peripheral part of the circulatory system, increase the supply of oxygen to tissues, increase the outflow and removal of aggressive toxins and free radicals from skin cells.

As a result, the skin becomes smoother, more hydrated and acquires a beautiful and even color.

Nicotinic acid is also used for hair growth. One course usually requires at least 30 ampoules with a solution.

After opening the ampoule, the solution is transferred with a syringe into a small container, after which it is distributed with fingers (or a syringe without a needle) over the entire scalp: first at the temples and along the hairline, then along the partings. Usually, 1 ml of solution is sufficient for one procedure (this corresponds to the volume of the contents of 1 ampoule).

It is very important that the hair is clean, as a coating of dust and grease will prevent the drug from being absorbed into the scalp. Before using the drug, shampoos with silicones should not be used to wash the hair, as they will create a barrier for the penetration of the drug into the tissues.

Nicotinic acid is quickly destroyed in the air, so the procedure should be performed as quickly as possible. An open ampoule is not subject to storage.

Normal reactions to the drug are a slight burning sensation, a crawling sensation, redness and burning of the skin.

The appearance of urticaria, rash, itching, headaches indicate intolerance to nicotinic acid. If these symptoms occur, you must wash your hair and stop using the product.

If, after applying nicotinic acid for hair, the scalp becomes dry or appears, it is recommended to dilute the solution with water in a ratio of 1: 1. Such reactions are a consequence of the sensitivity of the skin. Can also be used as an alternative to water aloe juice.

After the solution is completely applied, the procedure is considered complete. Repeat it daily for a month. It is not necessary to wash off the drug.

After completing the course, almost all girls note hair growth of 3 cm.

An injection solution of nicotinic acid has also found application as a remedy for cellulite. Before the procedure, the contents of one ampoule are diluted in 3 ml of water. Then, in the resulting solution, a wide bandage is moistened and tightly - but not tight! - Wrap them with problem areas.

Most effectively, this method allows you to get rid of cellulite on the hips and abdomen, since it is these areas of the body that are most convenient to bandage. But to eliminate cellulite on the buttocks, it is recommended to use other means.

The bandages are wrapped with cling film and a towel (for insulation). Instead of a towel, you can use a blanket or blanket.

The duration of the first procedure should not exceed 15 minutes. If the skin responds well to the drug, and there are no adverse reactions, the time may be increased in the future.

Precautionary measures

It should be borne in mind that Nicotinic acid injections are painful.

During treatment, it is necessary to constantly monitor liver function, especially if the patient is prescribed high doses. vitamin B3.

To prevent hepatotoxicity, it is recommended to introduce a sufficient amount of rich methionine products (milk, dairy products, buckwheat, legumes, fish) or appoint him to take lipotropic drugs (including drugs methionine).

Nicotinic acid, given its ability to irritate the mucous membrane, is used with caution when peptic ulcer(in remission) and hyperacid gastritis. If it is necessary to prescribe the drug in these cases, taking large doses is contraindicated.

To reduce the irritating effect on the mucous membrane of the digestive tract, it is recommended to drink the tablets with milk.

Because of the potential for hepatotoxicity, high doses vitamin B3 also contraindicated in liver diseases (including hepatitis and cirrhosis) and diabetes.

The use of the drug for correction dyslipidemia at diabetes impractical.

Synonyms: Nicotinic acid-Vial, Nicotinic acid-Bufus.

Analog: Nikoshpan.

Nicotinic acid: compatibility with alcohol

The drug helps to eliminate heavy metals and toxic substances from the body, so it can be used both when drinking alcohol and to eliminate the consequences of poisoning them.

Nicotinic acid for weight loss

Nicotinic acid stimulates the course of metabolic processes, and it is this property that makes it appropriate to use the drug for weight loss.

The effect develops not by burning excess fat, but by balancing the concentration cholesterol in the blood and detoxify the body.

To achieve more pronounced results, taking the tablets should be combined with reasonable physical activity, a balanced diet and drinking enough water. To speed up the metabolism as much as possible, it is best to take the tablets immediately after a meal.

It should be remembered that people with high acidity of gastric juice should take the drug with warm milk or mineral water.

Nicotinic acid during pregnancy

During pregnancy and during breastfeeding, high doses of the drug are contraindicated.

Reviews about nicotinic acid

Reviews of nicotinic acid tablets, as well as reviews of nicotinic acid injections, are in most cases positive.

The drug has extensive indications for use and is effective in osteochondrosis various parts of the spinal column, circulatory disorders in the brain and lower extremities, pellagra, decreased visual acuity, dyslipidemia, migraines, obesity, alcohol, occupational or drug intoxication, atherosclerosis and a number of other conditions.

Negative reviews are mainly due to the fact that after taking the pills or administering the injection solution, the patient had a feeling of heat and severe reddening of the skin. However, the instructions indicate that such phenomena are a normal physiological reaction of the body.

Reviews about nicotinic acid for hair are also quite optimistic. The tool helps to strengthen the roots, improves blood circulation of the scalp, perfectly moisturizes the hair, eliminates dandruff, accelerates hair growth and prevents hair loss.

The metabolic effect of the drug allows it to be used to accelerate the breakdown of fats in programs aimed at reducing excess weight.

Despite the huge number of useful properties, nicotinic acid is a rather serious drug, the thoughtless use of which can lead to negative consequences for the body.

The expediency of prescribing the drug in one form or another can only be determined by a doctor.

The price of nicotinic acid

The price of Nicotinic acid in tablets in Russian pharmacies is from 12 rubles. You can buy ampoules for an average of 90-100 rubles per package No. 10.

In Ukraine, the price of Nicotinic acid in ampoules is from 25 UAH for 10 injections. Tablets will cost about 8-9 UAH.

Having learned how much Nicotinic acid costs, we can say with confidence that this is one of the most inexpensive products for hair, face and nails.

Internet pharmacies in RussiaRussia
Internet pharmacies of UkraineUkraine
Internet pharmacies of KazakhstanKazakhstan

WER.RU

Nicotinic acid solution for injections 10 mg/ml 1 ml 10 pcs Ozon LLC

Nicotinic acid tablets 50 mg 50 pcs Pharmstandard

Nicotinic acid Bufus solution for injections 10 mg/ml 1 ml 10 pcs.Renewal

ZdravZone

Nicotinic acid-vial 1% solution for injections 1ml №10 ampoules

Blagomin Vitamin PP (nicotinic acid) No. 90 capsulesVis OOO

Nicotinic acid 1% solution for injections 1ml No. 10 ampoulesDalhimfarm OAO

Nicotinic acid 50mg No. 50 tabletsPharmstandard-Ufavita OAO

Nicotinic acid Renewal for hair 5ml №10 ampoules bufusUpdating PFC CJSC

PaniApteka

Nicotinic acid tab. #50Darnitsa

BIOSPHERE

Nicotinic acid 1%/1 ml №10

Nicotinic acid 1% / 1 ml No. 10 solution for in.amp.

NOTE! Information about medicines on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before medicine use Nicotinic acid surely consult with the attending physician.

medicalmed.ru

Nicotinic acid is an essential substance for the body. It is involved in recovery processes and is suitable for the complex treatment of many diseases. Now nicotinic acid is produced in the form of tablets and liquid for injection. We will tell you how to use this drug correctly, and what side effects it has.

Indication for the use of the drug

The unique composition of nicotinic acid has an anti-pellagic effect. Therefore, doctors most often prescribe the drug to patients for the treatment of pellagra. This medicine is also called vitamin PP. If you start therapy with nicotinic acid in the early stages, then the disease can be completely cured.

Also, the drug improves the metabolism of carbohydrates in the body. That is why nicotinic acid is also suitable for the treatment of such diseases:

Improves the condition in mild diabetes;
It is prescribed for any diseases of the liver and kidneys;
Suitable for complex treatment of the heart;
Doctors prescribe the drug for stomach ulcers;
For problems with the duodenum;
At the time of severe inflammation of the small or large intestine;
For the rapid healing of any wounds or deep ulcers.

In addition, the drug acts as a vasodilator. If it is necessary to lower blood lipoproteins, doctors prescribe 3-4 grams of nicotinic acid per day to patients. This is a fairly high dose, but in this case it will be appropriate.

Doctors often prescribe the drug to a patient with hypercholesterolemia. Nicotinic acid will lower blood cholesterol and improve the condition of the body. Also, the drug is prescribed for the treatment of any diseases in the stomach and liver:

Often used for gastritis;
For the treatment of inflammation in the stomach;
Suitable for patients with low acidity;
It is prescribed for acute hepatitis;
Great for cirrhosis of the liver;
Used for spasms.

Nicotinic acid is used to heal wounds and ulcers on the face that are not amenable to other drugs. The medicine is also suitable for the treatment of inflammation of the facial nerve. Doctors actively use nicotinic acid for atherosclerosis and for any infectious diseases.

The drug is suitable for the treatment of many diseases. However, each case has its own dosage of nicotinic acid and features of use. This should be told by the attending physician after a complete examination of the patient.

How to use the drug correctly

For treatment, nicotinic acid is prescribed in tablets or in the form of injections with a solution. You can use the drug as a disease prevention. For this, the doctor prescribes a dose of tablets not more than 0.025 g per day. Babies can be given for prevention at 0.005 grams per day.

For the treatment of pellagra, adults take 0.1 grams of nicotinic acid in tablets. The frequency of admission per day is 3-4 times. Usually the course of treatment with tablets is 2 weeks, depending on the diagnosis. You can use nicotinic acid in the form of a solution. Then the doctor injects the patient with 1 ml of the drug 2 times a day. A 1% solution is used. The course of treatment for parenteral administration is 18 days.

For the treatment of other diseases, the dosage is determined by the doctor individually. Most often, 0.04 g of nicotinic acid is prescribed per day for an adult. Babies should be given no more than 0.03 g of the drug. For children, it is better to divide the intake into 2-3 sets per day.

Often doctors use nicotinic acid as a vasodilator. The drug is especially effective in ischemic stroke. For this, the patient is injected with 1 ml of the solution into a vein. A 1% composition must be used.

How to administer the injection correctly

The specialist must inject nicotinic acid into a vein slowly. It is necessary to know that when administered subcutaneously or intramuscularly, the patient feels severe pain. That is why these methods are not used for nicotinic acid. To avoid skin irritation after an injection, doctors use sodium nicotinate or the substance nicotinamide.

The highest dosage of the drug

It is necessary to know the maximum doses of nicotinic acid, which in no case should be exceeded. Adults can take no more than 0.1 g of the drug in a tablet at a time. The maximum daily dosage is not more than 0.5 g.

If the doctor injects the drug into a vein, it should not exceed a dose of 0.1 g at a time. The maximum you can enter into the body is 0.3 g per day.

Many experts noted that when using nicotinic acid in the form of tablets, the dosage may increase. This is decided only by the attending physician after examining the patient. If a person has no side effects, and he tolerates therapy well, then the doctor raises the dose to 5 g per day. Most often this is done for the treatment of atherosclerosis and for serious disorders in lipid metabolism.

Side effects of the drug

Some patients may experience mild side effects when using nicotinic acid. The drug has never led to dangerous complications at the correct dosage. The most common symptoms on first use are:

The face becomes red;
The patient feels a slight dizziness;
There is a feeling that there is a strong rush of blood to the head;
A rash appears on the body;
In rare cases, the limbs of the arms or legs may become numb for a while;
A decrease in pressure in a patient with the rapid introduction of nicotinic acid through a vein.

All side effects disappear on their own in 1-2 days. Most often, such complications occur when taking tablets on an empty stomach. Allergies may occur in patients with hypersensitivity.

If the unpleasant symptoms do not go away after 2 days, you need to stop taking nicotinic acid and consult a doctor. Perhaps a dosage adjustment is required or this drug is simply not suitable for the patient.

Contraindications to the use of the drug

You need to know when nicotinic acid is strictly forbidden to be taken. The instructions for use describe such contraindications:

Severe forms of hypertension;
With a frequent increase in pressure, injections are prohibited;
Advanced form of atherosclerosis;
Dangerous drug for patients with allergies to nicotinic acid;
With an ulcer in the stomach;
At the time of exacerbation of the disease in the duodenum;
If the patient has severe disorders in the liver and kidneys;
Forbidden for gout;
It is not prescribed at the time of hyperuricemia and with neurosis;
Dangerous with sinus tachycardia and nephrosclerosis;
Not used at the time of severe arrhythmia;
Dangerous in any inflammatory processes in the body;
With decompensation in the blood circulation.

If a person is allergic to nicotinic acid, the doctor should prescribe nicotinamide. Sometimes this medicine can be used for such patients if it is used as a vasodilator.

If you use nicotinic acid in such diseases, serious complications can begin in the body and dangerous side effects can appear.

Medicine overdose

If the patient takes high doses of nicotinic acid for a long time, this leads to fatty degeneration in the liver. To prevent such a complication, doctors advise eating foods with methionine and amino acids. In extreme stages of overdose, the doctor should prescribe prolipotropic drugs to interact with fats in the liver.

If the patient has taken too much nicotinic acid, you should immediately consult a doctor. In case of side effects, you need to stay in the hospital under the supervision of specialists.

Use of the drug for children

In extreme cases, nicotinic acid can be used to treat pellagra in babies. But doctors advise replacing this drug with other donors. For complex therapy, nicotinamide or sodium nicotinate is perfect. The recommended dosage for babies is from 6 to 18 ml of the drug per day. Also, these drugs are suitable for the prevention of pellagra.

Use of medicine for pregnant women

Doctors categorically forbid the use of nicotinic acid by pregnant women in any trimester. The composition of the drug can harm the health of the baby. It is also not recommended to take pills at the time of breastfeeding. Through milk, the substance enters the fragile body of the baby. This may cause allergies or other dangerous consequences.

The effect of the drug on transport management

Doctors strongly recommend that you refrain from driving during nicotinic acid therapy. It is also necessary to abandon other activities that require a lot of attention and concentration. Remember that at the time of taking the tablets, dizziness and a decrease in reaction may begin. When driving, this may cause an accident.

Interaction with other drugs

It is necessary to know exactly how nicotinic acid will act when other drugs are taken in parallel. Doctors noted that it greatly potentiates the effect of any cardiac glycosides. This is especially true of digitalis glycoside.

Also, in no case should you mix two solutions in one syringe. The compound of nicotinic acid and cyanocobalamin is dangerous. Together, these two drugs increase the allergic reaction and can cause dangerous side effects. With simultaneous administration, cobalt vitamins are destroyed in the body.

If you are taking other medications, be sure to tell your doctor before the main therapy. Perhaps the doctor will reduce the dosage of nicotinic acid or tell you to stop taking other drugs.

Pharmacological property of the drug

Doctors noted that nicotinic acid helps in transporting phosphate throughout the body. The substance does an excellent job with nitrogen and carbohydrate metabolism in cells. It is this acid that regulates the synthesis of human DNA. Often the drug is used to treat wounds and ulcers that do not heal well due to the weakness of the body.

Nicotinic acid is absorbed into the blood within 30 minutes and immediately begins the recovery process. In the cells, it turns into an oxidizing compound and after a certain time is excreted in the urine.

Medicine storage rules

Nicotinic acid in the form of ampoules and tablets should be kept in a dark place, away from direct sunlight. It is important that children cannot easily get the drug. The optimum temperature for storage is no more than 23 degrees. The prepared solution must be used immediately. It is not subject to long-term storage without an ampoule. The shelf life of the drug from the date of manufacture is no more than 5 years in the original packaging.

Medicine price

The drug can be purchased at any pharmacy without a doctor's prescription at the following prices:

Nicotinic acid in the form of 1% ampoules - 60-70 rubles for 10 pieces of 1 ml;
Nicotinic acid in tablets of 50 mg - 20-40 rubles for 50 pieces.

Reviews about the medicine

Nicotinic acid is used in the treatment of many diseases. That is why you can find a lot of patient reviews about the effect of this drug. We have highlighted some of them:

Anna, 38 years old. Every year I come to a doctor I know and do a whole course of injections with nicotinic acid. I undergo such a procedure to prevent many diseases and to improve my general condition. After the introduction of the drug into a vein, the general blood circulation in the vessels improves. The doctor says that this has a positive effect on improving memory and helps with mental work. After the procedure, I feel a surge of strength and energy. Sometimes I do unscheduled injections in the hospital during stressful situations and nervous tension. Nicotinic acid really has a positive effect on the body and restores its work;
Ekaterina, 40 years old. I use nicotinic acid tablets to improve hair growth. I drink the course immediately after the winter, when the curls are weakened and look unattractive. The medicine has never caused side effects. I drink pills only after meals, as the doctor said. In a month I already see the result - the hair grows by 2 cm and looks stronger. The drug is inexpensive and really effective for beauty;
Valentin, 42 years old. The doctor prescribed nicotinic acid to restore the liver after hepatitis. I took the pills daily for 2 weeks. They are slightly sour in taste. Once I felt a side effect when I took the medicine before meals in the morning. The blood began to rush strongly to the head, I felt dizzy. However, after an hour everything went away, and there were no more complications. The doctor said that if you take the drug only after eating, then there will be no such problems. After a course of therapy, I underwent diagnostics and saw that the liver had indeed recovered from the disease. Nicotinic acid did an excellent job.

osteoz.ru

Nicotinic acid - injections

Injections of nicotinic acid (nicotine) are prescribed for various diseases. The thing is that it affects the body in different ways with certain ailments. This drug belongs to the vitamin group of medicines.

Why are nicotinic acid injections prescribed and their beneficial properties

Basically, this drug has a positive effect on the body:

normalizes the metabolic process;
restores the neural structure;
leads to a normal state of blood circulation in certain areas and throughout the body as a whole;
promotes vasodilation, normalization of oxygen absorption and restoration of oxidation processes inside the body;
removes toxins from the body.

Nicotinic acid injections - indications

The drug is used to treat many ailments:

stroke;
circulatory disorders in the head and limbs;
noise in ears;
pellagra;
poor glucose tolerance;
haemorrhoids;
obesity;
liver disease;
blurred vision;
with medication, alcohol or occupational intoxication.

Often the drug is prescribed for prevention. It helps to reduce the possibility of the formation of cancerous tumors in the body and accelerates the breakdown of fats, which favorably affects their absorption in the body. In addition, it is prescribed to: remove any symptoms of hemorrhoids; treatment of gastritis; improving memory and vision.

Contraindications to the use of nicotinic acid injections

Despite the many positive properties, nicotine still has contraindications. So, it is not desirable for use by people who have the following ailments: atherosclerosis; stomach ulcer; problems with the duodenum; gout; hepatitis at different stages; diabetes mellitus or simply their body does not interact with the drug.

However, it should be taken with some caution to patients:

with glaucoma and arterial hypotension;
during pregnancy or during lactation.

Side effects

If nicotinic acid injections are prescribed for the treatment of bones, for example, with osteochondrosis, you need to be prepared for some side effects. With short-term use, the main ones are: skin rash and itching, unstable breathing, the appearance of pain and dizziness. In addition, there is a feeling of increased body temperature. Basically, after a while, all the symptoms go away on their own.

With prolonged use of nicotinic acid in injections, for example, to improve blood circulation, it is imperative to monitor other indicators of the body. The thing is that if the drug enters the body excessively, the following problems may develop:

liver dystrophy;
impaired glucose uptake;
violation of the composition of the blood.

At the same time, the injections themselves are considered painful.

Consequences of an overdose

The dose is assigned to each person separately, based on personal indicators of the body and age. If the amount of the drug for injection is incorrectly calculated, some discomfort may occur. So, the most common is a temporary rush of blood to the upper body and head, itching all over the body and indigestion. Symptoms generally go away on their own after a while, or are treated separately.

Application for weight loss

One of the most popular ailments, from which injections of the drug nicotinic acid help, is overweight. Many nutritionists and personal trainers prescribe this particular medication, as it promotes the burning of fat cells. It is prescribed both in injections and tablets.

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Nicotinic acid - injections for health

Vitamin PP is just as important for the body as other trace elements. Nicotinic acid has an active effect on the body, injections of which are used to treat a huge number of diseases.

A distinctive feature of nicotinic acid

It is not recommended for diabetics, as it negatively affects blood vessels. It should be taken into account that nicotinic acid is better absorbed in tablets, injections are too painful. During injections (after 10-20 minutes), redness begins to be observed, therefore it is recommended to lie down for several minutes after the procedure. But even when taken orally, the dose should be increased little by little. Usually this drug is prescribed in an amount of 50-300 mg per day. It removes methyl radicals from the body, so it is taken simultaneously with methionine, vitamin U and choline chloride. And the diet should include more cottage cheese. The drug can be obtained at the pharmacy in the form of tablets of 50 mg or ampoules of 1 ml of a 1% solution.

Action spectrum

Acid is known not only as a vitamin, it is also famous for its other properties. So, it is widely believed that nicotinic acid is useful for lactation. To do this, it is recommended to take the medicine 2 times a day half an hour before the start of feeding (1-1.5 tablets each - it is advisable to find out the dosage from a specialist).

beauty acid

Most of the beauties who strive to grow chic hair sooner or later come across this pharmacy remedy. Many cosmetologists recommend a course of this drug, as they know that nicotinic acid for the skin is a means of its rapid recovery. Within a couple of weeks after taking the course of the drug, the skin becomes much more radiant and healthy.

Side effects of nicotinic acid

Like any other drug, it cannot but have negative effects. They are associated with the release of histamine, and this is reflected in a person as follows: redness of the skin appears, accompanied by itching. Pressure may also decrease, dizziness, nausea and diarrhea may appear. And even if all these phenomena were caused by nicotinic acid, injections do not have to be canceled yet. Gradually, the body will adapt to the release of histamine and after a while will stop responding so actively to it. But in some cases, a revision of the doses and duration of the drug is required.

Contraindications for the use of nicotinic acid

First of all, nicotinic acid should be used with caution for those who experience digestive problems - it can, for example, cause an exacerbation of stomach ulcers and inflammation of the duodenum. It is forbidden to prescribe tablets to children under the age of two years and parenterally at any age. Care should be taken to take nicotinic acid for people suffering from gout, disorders of the liver and kidneys, as well as those who have a tendency to bleed. If nicotinic acid is used for too long, injections can cause appetite disorders, vomiting, diarrhea and even liver dysfunction, exacerbation of diabetes.

"Nicotine". Injections and tablets, their purpose and indications for use

Vitamin PP (nicotinic acid, niacin, nicotinamide) is one of the most important components of the human body. The lack of this vitamin entails the appearance of a serious disease - pellagra, which, if left untreated, can lead to death. Pellagra is manifested by a depressive state of the patient, sometimes - diarrhea, vomiting. Often with pellagra, the patient has hallucinations, accompanied by confusion of thoughts. The appearance of such signs of the disease should cause concern, is the lack of nicotinic acid the cause of these symptoms? In the people, this component is often called simply - "nicotine". Injections, instructions for their administration, consultation, basic recommendations can only be issued by competent employees of medical institutions.

Where is nicotine naturally found?

The main suppliers of vitamin PP (nicotine) are food. A lot of nicotinic acid contains meat, fish, milk, liver, pectoral muscles of chicken. Plant foods such as tomatoes, cucumbers, potatoes are also pantries that contain nicotine. Injections, diet food, tablets are prescribed by a doctor in case of insufficient or complete absence of this vitamin in the patient's food products.

The body's need for nicotine

The need for this vitamin preparation in different people varies, depending on age and physiological state. A healthy adult who consumes a normal diet that includes nicotine will most likely not need injections, since the daily intake for such people is only about 20 mg of the vitamin. In boys, the need for nicotine is higher than in girls, and women during pregnancy, as well as when breastfeeding, should consume 25 mg of the drug daily.

Nicotine for kids

The daily norm of vitamin PP for six-month-old babies is relatively high. It should not be lower than 6 mg. It is advisable to take into account the composition of food in a child who simply needs nicotine for growth and development. Injections of vitamin PP, which adults receive, can harm babies. In addition to the possibility of causing a breakdown of the child's nervous activity by injections, there is a danger of severe burning of the skin, which can also bring harm to a small organism.

Diagnosis

With the main symptoms of the disease, the cause of which is a lack of necotinic acid (nicotine), instructions, as well as recommendations for effective treatment, can be received by patients only after an accurate diagnosis is confirmed. When it is formulated, as the main argument, the quantity, composition and even the method of cooking are taken into account. By analyzing only these components, you can definitely make a diagnosis. This is due to the good tolerance of cooking with vitamin PP. It is not lost during freezing of products, during drying, and also after exposure to high temperatures. Thus, extreme conditions are needed under which a person will completely stop receiving products containing an irreplaceable vitamin. This fact is of paramount diagnostic value.

Treatment of a disease caused by a lack of nicotine

After confirming that the cause of the disease is a lack of such an element as nicotine, injections will be the most effective method of treatment. This is due to the fact that injections of nicotinic acid begin to act very quickly, without causing an irritating effect on the gastrointestinal tract, which is typical for tablets. However, long-term use of the drug, as well as its increased doses, can harm the body. It has been proven that vitamin PP prevents the body from absorbing methionine, and this entails the occurrence of another disease. Therefore, it is recommended during injections of nicotinic acid to enrich the diet with foods that have a high content of methionine - cottage cheese, milk, cheese, eggs, fresh fish, soy products and meat.

Nicotinic acid (shots)

Nicotinic acid (injections) refers to specific antipellagric agents. In this regard, the drug has the designation "PP-vitamin". Nicotinic acid (injections), when used in the initial stages of pellagra, helps to eliminate its phenomena.

In addition to anti-pellagric properties, vitamin PP improves carbohydrate metabolism, has a positive effect on mild diabetes, heart disease, liver disease, duodenal ulcer and stomach ulcers, and enterocolitis. Nicotinic acid (shots) has a vasodilating property, and also promotes wound healing.

PP-vitamin has a lipoproteinemic effect, reducing the level of lipoproteins in the blood.

Nicotinic acid (injections) contributes to the normalization of the brain and nervous system. In addition, its positive effect on the cardiovascular system, digestion is noted. Nicotinic acid for the skin is one of the main assistants in maintaining it in a healthy state. In addition, PP-vitamin helps to ensure normal vision, is involved in improving blood circulation, reducing high blood pressure due to its vasodilating properties.

Nicotinic acid for lactation is a stimulant. Vitamin PP is involved in vascular blood filling and acceleration of blood circulation in the mammary gland.

The drug is available in ampoules.

In ischemic stroke, PP-vitamin is administered intravenously. The dosage is one milliliter of a one percent solution.

Intravenous administration must be carried out slowly. Rapid intravenous administration of the solution can provoke a significant decrease in blood pressure. Intramuscular and subcutaneous administration of nicotinic acid causes pain.

Taking the drug orally (in the form of powder or tablets), in particular, on an empty stomach or by persons with hypersensitivity, can cause dizziness, redness of the upper torso and face, a feeling of a rush of blood to the head, paresthesia (numbness in the limbs), nettle rash. As practice shows, these manifestations are eliminated on their own after a certain period of time.

Intravenously, the drug is contraindicated in persons with severe hypertension (with a pronounced persistent increase in blood pressure) and atherosclerosis.

If hypersensitivity to nicotinic acid is detected, the drug is recommended to be replaced with nicotinamide. An exception may be cases of using the drug as a vasodilator.

In order to increase lactation, the drug is prescribed fifty milligrams orally up to three times a day ten to fifteen minutes before breastfeeding.

When prescribing during lactation, it is necessary to warn the patient about a possible short-term reaction (redness on the face and upper body, feeling of fullness of the mammary glands, in rare cases itching). The appointment of nicotinic acid is recommended in combination with ascorbic acid.

It should be noted that long-term intake of vitamin-PP in large doses can provoke the development of fatty liver. In order to prevent this complication, foods rich in methionine (an amino acid not synthesized in the body) should be included in the diet, or methionine and other lipotropic (selectively interacting with fats) agents should be prescribed.

Nicotinic acid is included in the composition of such drugs as: "Vitaiodurol", "Xanthinol Nicotinate", "Vicein", "Nikoverin", "Lipostabil", "Spazmokor", "Nikospan" and others.

The appointment of the drug should be carried out only under the supervision of a specialist.

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The benefits and harms of nicotinic acid

Like any vitamin and remedy, nicotinic acid should be used with caution and competently.

The undoubted effect, benefit and high result of niacin is manifested in those who previously noted in themselves:

increased hair loss
dull, weak hair
dandruff,
slow hair growth

However, it also has contraindications and can lead to severe redness of the scalp, itching, headache and dizziness if:

you are prone to allergies, hives, and intolerance to certain drugs;
you suffer at least occasionally from high blood pressure.

The harm of nicotinic acid can be manifested by the appearance of side effects: severe irritation of the scalp, as well as dizziness and headache. In this case, immediately wash off the drug from the head!

It is possible to restore hair, improve its structure and appearance!

natasha protsenyuk

One milliliter of a 0.1% solution for injection contains 10 mg of the active substance, as well as sodium bicarbonate and water for injection.

In the State Pharmacopoeia of the USSR, X edition, it is indicated that the solution is a clear, colorless liquid with a pH of 5.0 to 7.0.

The concentration of nicotinic acid in one tablet is 0.05 grams.

Release form

Pharmacological forms of nicotinic acid: 1% injection solution and 50 mg tablets.

Ampoules with 1 ml of solution are packaged in 10 pieces in blister packs, 5 packs in a pack.

Tablets are sold packaged:

50 pieces in jars made of polymeric materials or dark glass;
10 pieces in blisters, 5 packs in a pack.

pharmachologic effect

Vitamin B . Compensates for the lack vitamin PP (B3) , renders vasodilator (vasodilating) , hypocholesterolemic and hypolipidemic action.

Pharmacodynamics and pharmacokinetics

Vitamin PP (nicotinic acid) is a vitamin that takes part in a large number of oxidative reactions occurring in living cells.

The drug has specific antipellagric action and used to improve performance blood vessels .

The appointment of nicotinic acid preparations allows you to normalize the permeability of the vascular walls and, accordingly, reduce the swelling of the tissue, improve the state of tissue (in particular, nitrogen and carbohydrate) metabolism and microcirculation, expand the lumen of the vessels (the vasodilating effect is noted at the level of small blood vessels, including those of the brain). brain), increase the fibrinolytic activity of blood plasma and reduce platelet aggregation by suppressing the synthesis of TxAj (thromboxane A2), a mediator of their aggregation and degranulation.

In the body vitamin PP biotransformed into nicotinamide , which binds to the hydrogen-carrying coenzymes NAD and NADP. Regulates oxidation-reduction reactions, takes part in synthetic processes, metabolism , purines , proteins , as well as in glycogenesis and tissue respiration .

Reduces the rate of VLDL synthesis and inhibits lipolysis (fat degradation) in adipose tissue. Contributes to the normalization of blood lipid composition: reduces the concentration of LDL, triglycerides and general while increasing blood levels of HDL. Manifests antiatherogenic and detoxifying properties .

Vitamin B3 well absorbed into pylorus of the stomach and upper duodenum . With the participation of and can be produced by the bacterial flora of the intestine from what comes with food. The amount required to form a milligram of a substance tryptophan - 60 mg.

Metabolism occurs in the liver. Nicotinic acid and its metabolic products are excreted by the kidneys; when taken in high doses, the substance is excreted mainly in its pure form.

Indications for use

Indications for the use of nicotinic acid are:

hypo- and avitaminosis due to inadequate intake vitamin B3 with food, exclusively parenteral nutrition, malabsorption syndrome (including against the background of violations of work pancreas ), Hartnup disease, rapid weight loss, gastrectomy , diseases of the digestive system ( persistent diarrhea , including tropical , celiac disease , Crohn's disease );
conditions with an increased need for vitamin PP (diseases of the hepatobiliary system, prolonged fever, prolonged stress, chronic infections, pregnancy, lactation, cancer);
hyperlipidemia (including triglyceridemia and hypercholesterolemia );
obliterating diseases of the vessels of the lower extremities (for example,);
ischemic circulatory disorders of the brain ;
spasm of the urinary and biliary tract, vessels of the extremities;
microangiopathy ;
diabetic polyneuropathy ;
hypoacid gastritis ;
and enterocolitis ;
neuropathy of the facial nerve ;
trophic ulcers and non-healing wounds.

Contraindications

Categorical contraindications for both dosage forms of the drug are serious violations of liver function, bleeding, cerebral hemorrhage, hypersensitivity to nicotinic acid.

Nicotinic acid tablets should also not be taken during periods of exacerbation. peptic ulcer and children under 2 years of age (as anti-sclerotic agent ).

Additional contraindications to the appointment of Nicotinic acid in ampoules are: atherosclerosis , hyperuricemia , severe arterial hypertension , childhood.

Side effects

The drug stimulates the release histamine , which in some cases may be accompanied by:

reddening of the skin (mainly the upper half of the body and face) with a burning sensation and tingling;
hypotension ;
orthostatic hypotension (with rapid introduction into a vein);
increased secretion of gastric juice;
dizziness;
sensation of a rush of blood to the head;
itching.

Side effects associated with long-term use of high doses vitamin B3 , are expressed as:

anorexia ;
dysfunction and fatty liver;
vomiting;
diarrhea ;
irritation of the mucous membrane of the digestive canal;
ulceration (ulceration) of the gastric mucosa;
transient increase in the activity of alkaline phosphatase, aspartate aminotransferase, lactate dehydrogenase;
paresthesia ;
decreased glucose tolerance;
hyperglycemia .

Application instruction of Nicotinic acid

Nicotinic acid injections: instructions for use

Antipellagric therapy involves a single or double administration of 50 mg intravenously or 100 mg intramuscularly. The duration of treatment is 10-15 days.

At ischemic stroke the drug is administered in a dose ranging from 10 to 50 mg.

Injections are allowed to be placed in three ways:

1 ml of a 1% solution into the muscle;
intradermally (to fill the need for a vitamin);
in a vein, 1-5 ml of a 1% solution, previously diluted in 5 ml of saline.

V / m and s / c injections of the drug are quite painful and may be accompanied by a burning sensation. Intravenous injection may cause reddening of the skin and a sensation of heat.

This reaction of the body is normal. On the contrary, the absence of redness may indicate the presence of certain problems with blood circulation.

Instructions for tablets

Tablets are taken after meals.

The prophylactic dose for adults varies from 12.5 to 25 mg per day, for children - from 5 to 25 mg per day.

With vascular lesions atherosclerotic genesis patients are recommended to take in 2-4 doses from 2 to 3 grams vitamin PP .

Starting dose at dyslipidemia - 50 mg per day in one dose. Subsequently, if the therapy does not provoke adverse reactions, the frequency of applications is increased up to 2-3 times a day. The duration of the course is from one month. Intervals should be maintained between repeated courses.

Overdose

High doses of the drug can cause a rush of blood to the upper body and head, indigestion and itching.

In case of overdose, supportive treatment is indicated.

Interaction

N. acid enhances the action vasoactive drugs (in particular, ganglionic blockers), which may be accompanied by seizures orthostatic hypotension .

Bile acid sequestrants (eg. colestipol or) reduce the bioavailability of acidic drugs, including n. acid, so the drug should be taken at least one hour before or no earlier than four hours after taking these drugs.

When conducting an analysis to determine the level of glucose in the urine, the drug may provoke a false positive reaction with Benedict's reagent (copper sulfate solution).

N. acid has a hyperglycemic potential and can significantly reduce the activity of acarbose, which can cause decompensation.

Due to the ability of Mr. acid cause hyperglycemia , in patients who are prescribed the drug in combination with “+ saxagliptin ” or “metformin + sitagliptin ”, you should constantly monitor the parameters of glycemic control.

In patients taking nadroparin calcium, it is necessary to control the indicators of hemocoagulation.

With the simultaneous use of n. acids and combinations “+”, n. acids and , n. acids and may increase the risk of developing myopathies . Combination n. acids with simvastatin can also provoke rhabdomyolysis .

Myopathy and rhabdomyolysis are also possible in the case of using the combination “n. acid in lipid-lowering doses and + ezetimibe ”.

Development risk myopathies also increases with the appointment of lipid-lowering (exceeding 1 gram per day) doses of n. acids in combination with . For this reason, treatment Rosuvastatin should start with 5 mg/day.

When used simultaneously with n. acid reduces the effect:

Glipizide ;
hypoglycemic effect Gliquidona ;
Insulina Lizpro (including two-phase);
Metformin ;
repaglinide ;
hypnotic effect .

Do not mix in one syringe. acid and.

Despite the fact that the simultaneous use of n. acids with HMG-CoA reductase inhibitors can provoke myopathy , while prescribing the drug with the bioavailability of the latter, as well as the bioavailability of n. acid, does not change. However, this combination should be used with caution.

Terms of sale

On prescription.

Recipe in Latin for the injectable form of the drug:
Nicotinic acid - ampoules
Rep: Sol. Acidi nicotinici 1% - 1 ml
D.t. d. N 20 ampull.
S. 1 ml / m.

Recipe in Latin for the tablet form of the drug:
Rep: Tab. Acidi nicotinici 0.05 g
D.t. d. No. 20 in tab.
S. 2 tablets 3 times a day after meals (with pellagra ).

Storage conditions

Store at room temperature in a well-closed container, protected from sunlight. Keep away from children.

Best before date

For solution - 5 years. For tablets - 4 years.

special instructions

What is vitamin PP?

The gross formula of the substance is C₆H₅NO₂. It was first obtained in 1867 by oxidizing nicotine with H2CrO4 (chromic acid).

The benefits and harms of vitamin B3

Clean vitamin B3 is able to strengthen so much that the human body acquires natural protection against Staphylococcus aureus and a number of other equally serious viruses.

Scientists are confident that very high doses can stop even HIV infection and bacterial infection, against which most of the existing drugs are powerless.

Besides, vitamin B3 has properties detoxifier .

The body of an adult male requires 16 to 28 mg daily. vitamin B3 , the body of a woman - from 14 to 20 mg.

If a person receives less nicotinic acid, he develops a disease pellagra . The first signs of the disease are:

frequent, watery stools (3 or more times a day, without impurities of blood and mucus);
poor appetite, heaviness in the stomach;
belching and heartburn;
redness of the oral mucosa;
salivation , burning in the mouth;
swelling and cracking of the lips;
protrusion of the papillae of the tongue with red dots;
the appearance of deep cracks in the tongue and red spots on the face, hands, elbows and neck;
swelling of the skin (the code may hurt, itch, blisters appear on it);
noise in ears;
severe weakness;
headache;
a feeling of crawling and numbness;
pressure fluctuations;
wobbly gait.

An excess of the vitamin, in turn, can cause skin rashes, itching and fainting.

Foods Containing Vitamin B3

To warn hypovitaminosis RR , it is preferable to adjust the diet so that the diet contains vitamin B3 containing products.