What is benzonal. Medicinal reference book geotar. Side effects of Benzonal

Prohibited while breastfeeding

Has restrictions for children

Has restrictions for the elderly

Forbidden for liver problems

Forbidden for kidney problems

Seizures can occur at any age and are more severe in children. For their removal, as well as the relief of epileptic seizures, special means are prescribed. One of them is Benzonal. According to the instructions for use, the product can be used in pediatrics, but Benzonal is a potent aggressive drug, so its use requires increased specialist supervision.

General information

Benzonal is a popular antiepileptic drug. It belongs to the list of potent drugs, therefore, it is prescribed only if there are appropriate indications. The medicine is produced by the domestic pharmaceutical company Aspharma LLC.

Drug group, INN, application

The drug belongs to a special drug group of barbiturates and their derivatives. Such drugs have antiepileptic and anticonvulsant effects.

The international non-proprietary name of a drug depends on the content of the active substance in it, which determines its action in the body. INN Benzonal - benzobarbital (Benzobarbital).

The drug is used in various fields of medical practice. It is intended for the relief and prevention of convulsive conditions and epileptic seizures in both adults and children of different ages.

Release form, cost

In pharmacies, the drug can be purchased in the form of tablets, each containing 50 or 100 mg of the active ingredient. Such tablets have a flat cylindrical shape and white color. They are packed in cell blisters of 10 pieces.

Benzonal can be purchased at a pharmacy with a special prescription from a doctor. Its price depends on the content of the active substance in 1 tablet and their number in the package. Also, the cost may vary in different pharmacies.

To date, it is very difficult to find a drug in pharmacies in Moscow and other Russian cities. It is practically not available anywhere, since it is included in the list of potent and poisonous medicines. As a rule, in order to get it, you should have a prescription, as well as pre-order by phone or on the pharmacy website. I managed to find a medicine in 2 pharmacies in Moscow - Avicenna Pharma and Terravita. The cost of a package of 50 tablets of 100 mg ranges from 99 to 110 rubles.

Composition and pharmacological properties

The composition of the drug includes the active substance benzobarbital. 1 tablet contains 50 or 100 mg. Additionally, there are auxiliary components - potato starch, methylcellulose and stearic acid.

The action of benzobarbital is directed to specific receptors of the central nervous system, the antagonist of which is gamma-aminobutyric acid (GABA). This substance reduces the permeability of the membranes of sodium nerve fibers, which helps to reduce the spread of impulses from the foci of epileptic activity.

Thus, an antiepileptic and anticonvulsant effect is provided. At the same time, the agent helps to increase the monooxygenase enzyme system of the liver, accelerates the transformation of bilirubin and other liver enzymes. Does not have a sedative effect.

The active substance, metabolized in the body, releases phenobarbital, which provides an antiepileptic effect. It practically does not bind to blood proteins, mainly its highest concentration is observed in the tissues and extracellular fluid of the brain, kidneys and liver. Benzobarbital is able to penetrate the placental barrier and into breast milk. It is excreted as metabolites and unchanged in the urine. Half-life occurs within 3-4 days.

Indications and restrictions

The drug is prescribed by the attending physician if the patient has appropriate indications. It is accepted for:

• convulsive forms of epilepsy of various origins. With the help of such a tool, generalized and focal epilepsy, partial seizures and epileptic syndrome are treated;
• seizures that are not accompanied by convulsions (small);
• polymorphic seizures.

In some cases, the drug is used for functional or benign hyperbilirubinemia (including post-hepatitis), which is accompanied by cholestasis and hemolytic jaundice.

Benzonal has some contraindications that should be considered before prescribing it. Such a tool is prohibited to take with:

The drug can be used in pediatrics, is prescribed for the treatment of seizures in children older than 3 years. Until this age, the medicine should not be given, since it contributes to toxic damage to the child's liver.

Pregnant women are also advised not to take this medicine. Benzobarbital is able to cross the placenta and cause severe fetal malformations. Therefore, women of reproductive age who take Benzonal should take care of reliable contraception.

Instructions for use

The dosage of the drug is selected by the attending physician individually for each patient, depending on his age and the nature of the seizures. The instructions for taking Benzonal include the following recommendations:

Take the drug for a long time - for a year or more. At the same time, it should be regularly consumed at 1 single dose per day, even in the absence of attacks. If the seizures return, then the previous dosage should be resumed.

It is important to remember that the medicine is contraindicated to be taken in combination with certain medicines. It enhances the effect of such drugs:

• narcotic painkillers;
• tricyclic antidepressants;
• funds for general anesthesia;
• tranquilizers and neuroleptics;
• sleeping pills.

Side effects, overdose symptoms

Benzonal is a potent and poisonous drug. Therefore, when taking it, such negative phenomena are often observed:

• lethargy, lethargy, drowsiness;
• a significant decrease in blood pressure;
• the appearance of a headache;
• loss of appetite;
• oppression of hematopoiesis (anemia, thrombocytopenia, thrombophlebitis);
• bronchospasm;
• allergic manifestations;
• slowing down mental reactions;
• impaired coordination of movements;
• nystagmus (twitching of the eyelid);
• speech problems.

It is also possible to develop dependence on the drug. After discontinuation (especially long-term) withdrawal syndrome is often observed.

An overdose can cause very serious disorders. In this case, symptoms of intoxication appear:

• violation of the functioning of the central nervous system, which is manifested by drowsiness, vision problems, ataxia and nystagmus;
• development of a coma;
• oppression of respiratory activity;
• a sharp drop in blood pressure;
• headache;
• high or low body temperature;
• constriction of the pupils;
• violation of cardiac activity (slowdown or acceleration of its contractions);
• hemorrhages;
• bluing of the skin.

If a person develops chronic benzobarbital poisoning, then he becomes irritable, sleeps poorly, and is unable to critically assess the situation. Treatment of an overdose is to remove harmful substances from the body. This requires gastric lavage and intake of sorbents. In severe cases, the patient is shown diuretics and hemodialysis. Then symptomatic therapy is applied.

The best analogues

In modern medical practice, benzobarbital-based agents are rarely used. Such a substance has severe side effects and has a toxic effect on the body. Therefore, in most cases, Benzonal analogues are used, which have a similar effect, but are safer. Among them:

Any antiepileptic drug is prescribed only by the attending physician. In pharmacies, it can only be purchased with a special prescription.

The medicine contains benzobarbital as an active substance.

Additional components: potato starch, water-soluble methylcellulose, stearic acid.

Release form

The drug is available in tablets.

pharmachologic effect

Benzonal is anticonvulsant medicine.

Pharmacodynamics and pharmacokinetics

Taking the medicine leads to the fact that seizures appear much less frequently. It encourages activity monooxygenase enzyme system liver, increases the rate of biotransformation exo- and endogenous connections , activates acetylation and glucuronization .

The drug has almost no effect sleeping pills effect. Antiepileptic the action occurs about half an hour or an hour after taking the tablets.

They quickly biotransform, getting into the body, with the release. The degree of association with proteins is weak. The active substance accumulates in the kidneys and liver.

Capable of passing through histohematic barriers and also excreted in breast milk. Mainly excreted through the kidneys. The half-life is 3-4 days.

Indications for use

Benzonal is used for epilepsy different origin, functional hyperbilirubinemia , as well as generalized and partial seizures .

Contraindications

You can not take the drug in case of hypersensitivity to its components, severe diseases of the liver or kidneys, chronic, severe, chronic heart failure at the stage decompensation , drug addiction, children under three years of age, porphyria , hyperkinesis , anemia , respiratory failure , suicidal tendencies.

Side effects

When taking this drug, you may experience lethargy, ataxia , nausea, speech disorders, slow reactions, dulling of hunger, irritability, thrombocytopenia , anemia , decline , bronchospasm .

In rare cases, it appears.

Application instruction of Benzonal (Way and dosage)

The instruction on Benzonal reports that the medicine is taken orally after meals. Dosages may be different depending on the age of the patient, as well as the frequency and nature of seizures. Adults, as a rule, are prescribed 0.1 g of the drug (but no more than 0.8 g can be taken per day). Children are shown the use of the drug in the following dosages:

• age 3-6 years - 0.025–0.05 g is prescribed;
• age 7-10 years - 0.05-0.1 is assigned.

Children from 11 years of age are shown the same dosages as for adults, but not more than 0.45 g per day. Instructions for the use of Benzonal indicate that, regardless of age, the medicine is taken 3 times a day. Therapy begins with a single dose once. After 2-3 days, the daily rate is increased to the optimum required for treatment. The duration of the course is also set individually. It is recommended to take the drug for at least two years, even if the seizures stop.

When hyperbilirubinemia tablets are used for about 2-3 weeks in the same doses as for epilepsy .

Overdose

The following overdose symptoms are possible:

• cases of mild and moderate severity -, drowsiness ;
• severe cases - , decreased reflexes, pronounced decrease HELL .

Treatment is gastric lavage and absorbents . In case of severe overdose, the patient is hospitalized. shown forced diuresis and , quinidine , xanthines reduces their effectiveness.

Terms of sale

It is impossible to buy Benzonal without a prescription from a specialist.

Storage conditions

Store the medicine in a dry and dark place (up to 25 ° C). Be sure to keep away from children.

Best before date

Four years. Tablets should not be taken after the expiration date.

Antiepileptic Benzonal has an anticonvulsant effect, reduces the spread of impulses from the focus of epileptic activity, does not have a hypnotic effect. Enhances inhibitory GABA-ergic effects in the central nervous system, especially in the thalamus, the ascending activating reticular formation of the brain stem at the level of intercalary neurons. The effect occurs 20-60 minutes after oral administration.
It is rapidly metabolized in the body, releasing phenobarbital, which has an antiepileptic effect. Communication with plasma proteins is weak. Creates high concentrations in the brain, liver and kidneys. Penetrates through histohematic barriers and into breast milk. The half-life is 3-4 days. It is excreted by the kidneys, both unchanged and as metabolites.

Indications for use:
A drug Benzonal used to treat epilepsy of various origins, generalized and partial seizures, epileptic syndrome, focal seizures, including Jacksonian epilepsy, Kozhevnikov epilepsy, small seizures (nonconvulsive).

Mode of application:
Benzonal take orally, after meals, 3 times a day. The dosage regimen is individual and is prescribed by a doctor.
Adults: Single dose - 0.1-0.15-0.2 g, maximum single dose - 0.3 g, maximum daily dose - 0.8 g. The course of treatment is continuous and long, at least 2 years.
Children: For children aged 3-6 years, a single dose - 0.025-0.05 g, daily - 0.1-0.15 g; 7-10 years one-time - 0.05-0.1 g, daily - 0.15-0.3 g; 11-14 years old one-time - 0.1 g, daily - 0.3-0.4 g; the maximum single dose for older children is 0.15 g; maximum daily - 0.45 g.

Side effects:
Of the side effects from the use of the drug Benzonal may occur: addiction, drug dependence, "withdrawal" syndrome, bronchospasm, lowering blood pressure, thrombocytopenia, anemia, thrombophlebitis, drowsiness, lethargy, lethargy, headache, loss of appetite, speech difficulty, ataxia, nystagmus, mental retardation; allergic reactions.

Contraindications:
Contraindications to the use of the drug Benzonal are: hypersensitivity, liver failure, renal failure, heart failure II-III degree, porphyria, anemia, bronchial asthma, respiratory failure, diabetes mellitus, hyperthyroidism, adrenal insufficiency, hyperkinesis, depressive states (with suicidal attempts), children under 3- x years, pregnancy (I and III trimester), lactation period.

Pregnancy:
It is contraindicated to take the drug Benzonal during pregnancy.

Interaction with other drugs:
Benzonal enhances the effect of narcotic analgesics, general anesthesia, neuroleptics, tranquilizers, tricyclic antidepressants, ethanol, hypnotics, reduces - paracetamol, anticoagulants, tetracyclines, griseofulvin, glucocorticosteroids, mineralocorticoids, cardiac glycosides, quinidine, vitamin D, xanthines.

Overdose:
Symptoms of drug overdose Benzonal: depression of the functions of the central nervous system (drowsiness, blurred vision, ataxia, dysarthria, nystagmus) up to coma, depression of the respiratory center, decrease in blood pressure, impaired renal function, headache, severe weakness, increase or decrease in body temperature, agitation, narrowing of the pupils , tachy- or bradycardia, cyanosis, hemorrhages in places of pressure, pulmonary edema. In chronic intoxication - irritability, weakening of the ability to critically assess, sleep disturbance, confusion.
Treatment: gastric lavage, activated charcoal, symptomatic therapy.

Storage conditions:
In a dry, dark place at a temperature of 18 to 22°C. Keep out of the reach of children. Best before date. 4 years. Do not use after the expiration date indicated on the package.

Release form:


tablets 100 mg; blister pack 10 carton pack 5
tablets 100 mg; jar (jar) polymer 50 cardboard pack 1


tablets 100 mg; blister pack 10 carton pack 5
tablets 50 mg; blister pack 10 carton pack 3
tablets 50 mg; blister pack 10 carton pack 5
tablets 100 mg; jar (jar) 50 carton pack 1
tablets 100 mg; jar (jar) 50 box (box) cardboard 50
tablets 100 mg; bank (jar) polymer 50 box (box) cardboard 50
tablets 100 mg; jar (jar) of dark glass 50 box (box) cardboard 50
tablets 100 mg; blisters packing 10 cardboard box (box) 600

tablets 100 mg; blister pack 10 carton pack 5
tablets 100 mg; blister pack 50 carton pack 5
tablets 100 mg; jar (jar) of dark glass 50 carton pack 1
tablets 100 mg; blister pack 10 carton pack 1
tablets 100 mg; blister pack 10 carton pack 2
tablets 100 mg; blister pack 10 carton pack 5
tablets 100 mg; blister pack 10 carton pack 5
tablets 100 mg; blister pack 25 carton pack 2

Compound:
1 tablet contains: active substance - benzobarbital (benzonal) 50 or 100 mg;
excipients: potato starch, stearic acid, water-soluble methylcellulose.

Benzobarbital (benzobarbital)

Composition and form of release of the drug

10 pieces. - cellular contour packings (5) - packs of cardboard.

pharmachologic effect

Antiepileptic drug. Virtually no sedative effect.

It enhances inhibitory GABA-ergic effects on the central nervous system, especially in the thalamus, the ascending activating reticular formation of the brain stem at the level of intercalary neurons. By reducing the permeability of nerve fiber membranes for sodium ions, it reduces the spread of impulses from the focus of epileptic activity. The effect occurs 20-60 minutes after oral administration.

Pharmacokinetics

It is metabolized to form, which has an antiepileptic effect. Binding to plasma proteins is weak. High concentrations are found in the brain, liver and kidneys. Penetrates through histohematic barriers, excreted in breast milk. T 1/2 is 3-4 days. It is excreted by the kidneys both unchanged and as metabolites.

Indications

Epilepsy of various origins, generalized and partial seizures.

Contraindications

Hypersensitivity to benzobarbital, severe renal and / or liver dysfunction, chronic insufficiency of stage II-III, porphyria, anemia, bronchial asthma, respiratory failure, diabetes mellitus, adrenal insufficiency, hyperkinesis, depressive states (with suicidal attempts); pregnancy, breastfeeding period; children's age up to 6 years.

Dosage

Set individually. Inside - 100 mg 3 times / day. Maximum doses: single - 300 mg, daily - 800 mg. Treatment begins with a single dose of a single dose. After 2-3 days, gradually increase the dose until a clinical effect is achieved (reduction in the frequency or complete cessation of seizures). The treatment is long.

Children 7-10 years old - 50-100 mg per dose (150-300 mg / day), 11-14 years old - 100 mg per dose (300-400 mg / day). Maximum doses for children (older age): single - 150 mg, daily - 450 mg.

Side effects

From the side of the central nervous system: rarely - drowsiness, lethargy, lethargy, ataxia, nystagmus, speech difficulties (in these cases, dose adjustment or caffeine administration is required).

From the hematopoietic system: thrombocytopenia, anemia.

From the side of the cardiovascular system: decrease in blood pressure, thrombophlebitis.

Others: loss of appetite, allergic reactions, bronchospasm.

drug interaction

Strengthening the effects of opioids, anesthetics, antipsychotics, anxiolytics, tricyclic antidepressants, ethanol, sleeping pills.

With simultaneous use, there is a decrease in the effectiveness of paracetamol, anticoagulants, tetracyclines, griseofulvin, GCS, mineralocorticoids, cardiac glycosides, quinidine, D, xanthines.

With simultaneous use with drugs that have a myelosuppressive effect, an increase in hematotoxicity is observed.

special instructions

In patients who have previously taken barbiturates, when switching to treatment with benzobarbital, sleep disturbances are possible. In these cases, phenobarbital (50-100 mg) or other sleeping pills are prescribed at night.

Photo of the drug

Latin name: Benzonal

ATX code: N03AA05

Active substance: Benzobarbital (Benzobarbitalum)

Analogues: Benzonal tablets

Producer: Tatkhimfarmpreparaty, Moscow Endocrine Plant, Asfarma (Russia)

The description applies to: 30.09.17