The most effective and inexpensive drugs for the liver: prevention, recovery, treatment. Hepatoprotectors What drugs to restore the liver

The main filter of our body - the liver - is daily exposed to negative influences that lead to a deterioration in the function of this organ. Despite the amazing regenerative ability of the liver, its cells, hepatocytes, sometimes lose their ability to withstand harmful effects, are infiltrated with fat and die.

As a result, the organ is exposed. To help him gain his former abilities, to stop the destructive process in her cells, a properly selected medicine for the liver or a whole range of drugs can.

In the arsenal of a modern pharmacy chain, there are more than one and a half thousand drugs for cleansing the liver and its restoration. Finding an inexpensive and effective medicine will help information about commercially available medicines.

Of the currently known pharmacotherapeutic groups for the liver, a class of hepatoprotective agents can be distinguished, that is, drugs that prevent the destruction of hepatocyte membranes and stimulate their regeneration. The rest of the medicines, intended mainly for parallel use, will be considered in the "Other drugs" section.

Hepatoprotective agents are the largest and most popular group of drugs used to improve liver function. The name comes from the Latin "hepar" - liver and "protecto" - to protect.

In clinical practice, the combination of hepatoprotective agents is usually classified by origin into synthetic and natural, and by pharmacodynamic properties: antioxidant, choleretic, metabolic, and others.

There are hepatoprotectors and chemical composition.

1. Amino acids. This group includes the active substances ademetionine, methionine used in medicines, Methionine, Hepa-Merz for the treatment and prevention of toxic liver damage, fatty degeneration and other pathologies.
2. Phospholipids. This group includes synthetic and vegetable phospholipids in the medications Phosphogliv, Antraliv, as well as their combinations with multivitamins ().
3. Bile acid preparations based on ursodeoxycholic acid. They are able not only to improve the regeneration of hepatocytes, but also to dissolve cholesterol stones (Ursodexa, Ursoliv, Ursosan,).
4. Synthetic hepatoprotectors based on arginine glutamate. The most commonly prescribed for the treatment of cirrhosis of the liver (Glutargin).
5. Vegetable hepatoprotectors. Used in the treatment of most liver diseases. Based on milk thistle - Karsil, Silimar, Forliver Help, capsules with pumpkin seed oil - Tykvelol,.
6. Herbal hepatoprotectors from prefabricated ingredients - Liv 52.

Hepatoprotective drugs have more than 96 trade names, so it is difficult to provide a complete list of these drugs.

For the treatment of the liver, medications and other pharmacological groups are used. These are choleretic and metabolic agents, multivitamins and dietary supplements to maintain the liver.

Choleretic plant-based medicine that restores the liver with postcholecystectomy syndrome (after removal), with biliary dyskinesia, and other pathologies.

Thiogamma

A drug based on thioctic acid from the group of metabolic agents used in the complex treatment of alcoholic neuropathy with liver damage.

Gepabene

A medicinal preparation based on herbs - and fume medicinal, represents a group of choleretic agents of plant origin.

Livolin forte

The multivitamin preparation Livolin forte is a combined remedy based on soy lecithin, vitamins E and group B. It helps normalize fat, protein and carbohydrate metabolism, improve the detoxifying properties of the liver.

The drug based on the extract of the artichoke field exhibits a choleretic effect. It is used as part of the complex treatment of biliary dyskinesia, chronic hepatitis, cholecystitis,.

Ovesol

In the treatment of the liver, biologically active additives (BAA), for example, Ovesol, are also widely used. BAA is not a medicine, but is sold to the public as a source of flavonoids.

Sandy immortelle

In pharmacies, you can buy dried immortelle inflorescences packed in cardboard boxes. The instructions indicate that the flowers have choleretic, choleretic, cholekinetic, antispasmodic and anti-inflammatory properties.

Effective medicines for the treatment

There is no universal cure for all cases of liver disease, but based on clinical practice and feedback from doctors and patients, one can rank the most effective remedies for the treatment of liver pathologies. The best drugs are those that have shown their effectiveness depending on the specific situation.

1. The most prescribed drug by gastroenterologists is called Ursofalk, it is effective for, including complicated ones.
2. The most popular medication among the population is Essentiale forte N from the group of plant phospholipids.
3. The best cure for liver diseases that occur with depressive states, including alcohol, according to patients -.
4. Excellent recommendations for the hepatoprotector based on soy phospholipids (lecithin) Rezalut Pro.

Factors that damage liver cells

List of inexpensive medicines

The cost of a medication is in many cases the most important factor of choice for a patient, so here it is appropriate to provide a list of inexpensive drugs for the liver. The leader in this list is a choleretic agent of plant origin Allohol based on nettle leaves, garlic bulbs, bile and activated charcoal.

Inexpensive and medicines with milk thistle:

• Silimar;
• Forliver Help.

Among medications with ursodeoxycholic acid, Ursofalk is also relatively inexpensive.

To prevent diseases and maintain the condition of the liver

Not all drugs for the liver are used for prophylactic purposes. Which medicine is better to use for the prevention and maintenance of the liver can be seen in the table compiled according to the instructions for use. The purposes of using these medicines are somewhat different.

Table of drugs for the prevention of liver disease

Prophylactic medication should be agreed with the doctor.

Recovery

Medicines with a regenerative (restoring) property include hepatoprotectors. Hepatoprotective agents are a large pharmacological group of drugs, including synthetic and natural hepatoprotectors. These are amino acids and phospholipids, bile acid preparations and plant-based hepatoprotectors.

Usually required after organ damage due to trauma, surgery, past infections and chronic intoxication (alcohol, drugs and other chemicals).

For the treatment of fatty liver and obesity

For cirrhosis and fibrosis

In the treatment of fibrosis and cirrhosis of the liver, hepatoprotectors are used, in the indications for which these diseases are present. Such instructions are available in the instructions for medications:

• Antraliv, Eslidin based on soy lecithin phospholipids;
• Heptor, Heptral, Sameliks - hepatoprotectors with the active substance ademetionine;
• Dipana, Karsil, Liv 52, Ropren, Silimar hepatoprotectors of plant origin;
• Livodex, Ursosan, Ursofalk, Choludexan, Exhol based on ursodeoxycholic acid;
• Progepar, - a combined hepatoprotective agent;
• Phosphogliv is a hepatoprotector based on phospholipids and glycyrrhizic acid;
• Phosfonciale, Essentiale - hepatoprotectors from the group of phospholipids.

In the treatment of fibrosis and cirrhosis, these drugs are used mainly in combination with other drugs for the liver.

Drugs for treatment should be prescribed by a doctor

With inflammation

Inflammatory processes in the liver, called hepatitis, occur as a result of a viral infection, toxic organ damage, and chronic gastrointestinal diseases. Therefore, from inflammation of the liver, drugs are used that eliminate the root cause of hepatitis:

• antiviral and immunomodulating agents;
• adsorbents;
• enzymes;
• choleretic agents;
• vitamins.

The choice of the drug also depends on the form of the course of hepatitis - acute or chronic, as well as on concomitant diseases (diabetes mellitus, HIV and others).

What is better to take after alcohol?

Taking high doses of alcohol, even at a time, can cause liver damage with a violation of its function - acute liver failure.

According to recent scientific studies, any dose of alcohol is hepatotoxic, so the best way to protect yourself from liver damage is not to drink it at all.

Since not all representatives of the human population possess such heroic self-control, some of them have a question, what medicine to drink after alcohol, so as not to "tear" the liver.

There are no drugs that are compatible with alcohol, so it is unreasonable to hope that you can drink “binge” with drugs. To support the liver, suffering from the effects of alcohol, you can still use the same variety of hepatoprotective agents.

Overview of reviews

According to the reviews of patients commenting on the therapeutic effects of drugs for the liver, Essentiale, Hofitol are recognized as the best (although its high price is mentioned among the shortcomings), Liv 52.

With regard to the latter, opinions are expressed that it has already been withdrawn from sale in pharmacies due to the discovery of problems with the quality of raw materials. But in the official directory of medicines, this drug is listed as certified with an indefinite registration expiration date, that is, approved for use.

In reviews of positive ratings received choleretic and hepatoprotective agents.

Useful video

See what doctors have to say about liver problems and their treatment:

Conclusion

1. The largest group of drugs for the liver are hepatoprotectors, including phospholipids, amino acids, bile acid preparations.
2. In addition to hepatoprotectors, metabolic agents, choleretic and multivitamin preparations are used in the treatment of liver diseases.
3. For prophylactic purposes, preparations of bile acids, hepatoprotectors of plant origin are used.

To eliminate liver diseases, special medicines are used. Consider the most popular and effective drugs, their types, indications for use and cost.

Medicines for the liver are called hepatoprotectors, they are prescribed by the attending physician to eliminate violations of the functioning of the organ. They are necessary for the restoration of organ cells during long-term antibacterial or anti-tuberculosis therapy, the use of painkillers, antitumor and other drugs.

Faced with the problem of choosing a drug, patients are interested in the same questions. Which remedy is better, more effective, safer and cheaper? To date, there are many hepatoprotectors on the pharmaceutical market, which are used both for treatment and restoration of the organ:

• Phospholipids.
• Herbal remedies.
• Derivatives of amino acids.
• Bile acids.
• Homeopathic preparations.
• Biologically active additives.
• Medicines of animal origin.

All drugs have different effects on the body and have different effectiveness. Focusing on the results of diagnostics and tests, the symptoms and severity of the disease, the doctor selects the medicine.

The largest gland in the human body is the liver. The body performs many important functions: it participates in digestion, accumulates blood and glucose, neutralizes toxins and harmful substances, produces hormones and enzymes, cholesterol, bilirubin. The slightest violations in its functioning negatively affect the well-being of a person.

Medicines for the treatment of the liver are used to eliminate various diseases and repair damaged cells. Consider the most popular of them:

1. Herbal hepatoprotectors

Available in the form of capsules and enteric-coated tablets. In this category, drugs have proven themselves well, which include silymarin, which has a pronounced healing effect:

• Karsil - tablets with active ingredient - fruits of dry milk thistle.
• Gepabene - capsules with an extract of medicinal fumes and milk thistle.
• Silimar - tablets with dry milk thistle extract and other substances.

They have a minimal toxic effect on the body.

1. Essential phospholipids

Medicines are used in the treatment and prevention of cirrhosis, fatty degeneration, chronic, toxic and alcoholic hepatitis, radiation syndrome. The drugs are components of the cell wall of hepatocytes. They penetrate into the lipid layer of damaged cells and improve their functioning.

Taking the medicine minimizes energy costs, increases the enzymatic activity and physicochemical properties of bile. To achieve a stable therapeutic effect, long-term use is necessary, preferably intravenous administration. The most popular medicine from this group is Essentiale and Essentiale Forte N.

1. Biologically active additives

Many patients are convinced that nutritional supplements and various dietary supplements are absolutely safe and can be taken without medical permission. But this is not the case, some additives have hepatotoxic properties and, when interacting with other drugs, cause many side effects. Dietary supplements are not used as the main means, they are used in complex therapy or as an auxiliary medicine.

, , , ,

Indications for the use of drugs for the liver

The use of any medication is possible only with the appropriate medical permission. Indications for the use of drugs for the liver depend on the severity of the underlying disease and the presence of concomitants, the age of the patient and other characteristics of the organism. To date, there are many hepatoprotectors that are prescribed in such cases:

• Hepatitis - most often prescribed to eliminate viral hepatitis, when antiviral agents did not have the expected result or such therapy is impossible. Hepatoprotectors are used both in complex treatment and for the prevention of the disease.
• Fatty degeneration - occurs in patients with type 2 diabetes and obese patients. In such patients, fat cells form in the liver, which disrupt its normal functioning. For treatment, hepatoprotectors, cholesterol-lowering agents, antidiabetic drugs, diet and physical activity are prescribed.
• Alcoholic hepatitis with a risk of cirrhosis - before starting treatment, it is necessary to completely abandon alcohol, since pharmaceuticals will not give a therapeutic effect. If alcohol intake continues, then no drugs will help restore the diseased organ.
• Toxic, medicinal hepatitis - medicines not only eliminate the symptoms of the disease, but also help restore the body. A prerequisite for recovery is the elimination of factors that provoked malaise.

It must be understood that it is difficult to completely restore the health of the liver only with drugs, so the patient is prescribed a special diet, physiotherapy, mandatory treatment of the pancreas and gallbladder, that is, the organs involved in digestion.

Medications to treat cirrhosis of the liver

One of the dangerous diseases that is practically not treatable is cirrhosis. The choice of the method of therapy and the drug depends on the stage and activity of the pathological process. To date, there are no such means that could completely eliminate the disease. Medicines are aimed at correcting possible complications and protecting the organ from further destruction.

Medications for cirrhosis of the liver:

• Inactive form - with compensated cirrhosis, vitamin preparations are used for treatment. As a rule, patients are prescribed vitamin-mineral complexes: Alphabet, Vitrum, Duovit, Biomax.
• Cirrhosis of moderate activity - patients are prescribed herbal and vitamin remedies. This is a vitamin complex of group B, vitamin C, rutin, folic and lipoic acid. Of the medicines, preference is given to preparations based on milk thistle and artichoke.
• Decompensated cirrhosis - at this stage, various complications appear. For therapy, lipoic acid is used, which is used orally / intravenously and various hepatoprotectors.
• Cirrhosis complicated by ascites - the patient is prescribed diuretics: Spironolactone, Furosemide, Triampur.
• Cryptogenic cirrhosis is the most dangerous form of the disease. For the treatment of pathology with an unknown cause, hepatoprotectors, herbal remedies, amino acid derivatives and other medicines are used.
• Viral cirrhosis - treatment is based on correcting the underlying disease. Most often, patients are prescribed Prednisolone. Dosage and duration of therapy is selected individually.

In the treatment of cirrhosis, not only drug therapy is necessary, but also diet, complete cessation of smoking and alcohol. If the pathology is detected in the early stages, then the liver can be restored.

Release form

The effectiveness of the drug is determined not only by its composition, but also by the form of release. Medicines for the liver are available in this form:

• Pills.
• Enteric-coated capsules.
• Powders for the preparation of solutions for oral administration.
• Ampoules for injection (drip and intravenous administration).
• Drops (for young children).
• Teas, phytocomplexes.

The doctor prescribes the most appropriate form of release, focusing on the course of the disease and the age of the patient.

, , , , ,

Pharmacodynamics

The effectiveness of a drug is determined by its biochemical properties. Pharmacodynamics provides information about the pharmacological group of the drug, its composition and indications for use. Consider these characteristics on the example of different groups of drugs prescribed for the treatment of liver diseases.

• Herbal hepatoprotectors

The active ingredients of Gepabene are extracts of medicinal plants. The active ingredient silymarin is derived from milk thistle fruit. It has a choleretic effect, normalizes the tone of the biliary tract and the amount of bile, improving its outflow into the intestines. Improves the function of protein formation, stabilizes hepatocyte membranes.

• Essential phospholipids

Essentiale is a highly purified fraction of phosphatidylcholine. The active ingredients are soybean phospholipids, which are similar in structure to the elements of hepatocytes. The lack of these substances leads to a violation of fat metabolism and the development of fatty degeneration. The medicine restores cellular structures, accelerates the regeneration process and slows down the formation of connective tissue.

Hepatosan is a drug with freeze-dried porcine liver cells. It enhances the detoxification function, absorbs and removes toxins, accelerates the regeneration of hepatocytes. It has two phases of action: intestinal and metabolic. At the first stage, detoxification of toxic substances in the intestine occurs, and at the second, biological components restore the functional activity of the damaged organ. The composition of the product includes vitamins, essential phospholipids, enzymes, amino acids.

• Amino acids

Ursosan is a hepatoprotector with a choleretic effect. Available in the form of capsules for oral use with the active substance ursodeoxycholic acid. Forms non-toxic mixed micelles with toxic bile acids, preventing damage to hepatocyte cell membranes. Reduces the amount of cholesterol in bile, promotes its absorption and excretion. Dissolves cholesterol gallstones and prevents the formation of new ones. The active component slows down the aging process and death of hepatocytes.

• Biologically active additives

Liv 52 is a combined drug with hepatoprotective, anti-inflammatory, choleretic and antitoxic effects. Improves the process of digestion and assimilation of food. Restores liver cells, minimizes any degenerative changes and enhances intracellular metabolism. Normalizes the level of bilirubin and other liver enzymes, improves the colloidal properties of bile and prevents stone formation.

Pharmacokinetics

For the treatment of diseases of the gastrointestinal tract, various drugs are used, which differ not only in their composition, but also in the forms of release. Pharmacokinetics allows you to learn about the processes of absorption and metabolism of the drugs used.

• Herbal hepatoprotectors

The active substance Gepabene is practically insoluble in water, forms salts with alkalis. If the drug enters the intestines, it is absorbed into the blood with split intestinal bacteria. The maximum concentration in plasma when taken orally is reached in 2 hours. Metabolites are excreted in the bile. The half-life is 5-6 hours.

• Essential phospholipids

About 90% of the taken dose of Essentiale is absorbed in the small intestine. The active ingredients are cleaved by phospholipase A to 1-acyl-lysophosphatidylcholine. Half of the resulting substance undergoes reverse acetylation during absorption in the intestinal mucosa. The maximum plasma concentration is reached within 6-24 hours after application. Excreted as metabolites in feces and urine.

• Animal products

Hepatosan is produced in the form of enteric-coated capsules for oral administration. After entering the body, the active substances quickly spread throughout the body, providing a therapeutic effect. Excreted as metabolites in the urine.

• Amino acids

Ursosan is absorbed from the small intestine and ileum. The concentration of the active substance in the blood plasma depends on the dose taken. Plasma protein binding is high, ursodeoxycholic acid crosses the placental barrier. Metabolized in the liver, excreted in bile, feces and urine.

• Biologically active additives

The pharmacokinetic properties of Liv 52 are due to the combined action of its active components.

Use of liver medications during pregnancy

Pregnancy is not only a long-awaited period for every woman, but also quite responsible. During gestation, the work of some organs and systems is disrupted, but the liver most often suffers. The process of blood supply is disturbed, which negatively affects the liver functionality. This process is considered natural, since after childbirth, the work of the body is restored. But expectant mothers may experience an exacerbation of chronic diseases that require treatment.

Consider drugs for the liver during pregnancy, which are used to prevent and eliminate pathological conditions:

• Essentiale Forte is a complex remedy with phospholipids that improves the cell membranes of a damaged organ. Consists of natural ingredients that do not penetrate the placental barrier. Can be used in any trimester.

• Legalon is a herbal medicine with the active ingredient milk thistle. It has a strong hepatoprotective effect, improves intracellular metabolism, stabilizes hepatocyte membranes. It is used to treat many diseases, regardless of etiology and severity.

• Karsil is one of the most popular medicines for repairing a weakened or damaged liver. The active ingredient is milk thistle extract. Used during pregnancy and for pediatric patients. Well tolerated, not addictive.

• Heptral is a hepatoprotective agent with the active substance ademetionine. It has a regenerating, detoxifying, antioxidant and neuroprotective effect. Effective in the treatment of toxic, viral and inflammatory liver lesions.
• Hofitol is a combined agent with choleretic, diuretic and hepatoprotective properties. The active ingredient is artichoke extract. It is used in chronic and acute course of diseases of the liver and organs.

Treatment of any diseases in expectant mothers has certain difficulties, since many drugs are contraindicated for use. The use of drugs for the liver during pregnancy is possible only for medical purposes. This is due to the fact that the active substances can penetrate the placental barrier, adversely affecting the development of the fetus.

A woman is selected safe drugs, usually plant-based. Many hepatoprotectors not only restore the functioning of the liver and digestive tract, but also alleviate the condition of a pregnant woman with toxicosis.

Contraindications for use

Medicines have not only indications, but also contraindications for use. Consider the prohibitions on the use of drugs to restore hepatocytes.

• Herbal hepatoprotectors

Gepabene is not allowed to be used in acute diseases of the liver and bile ducts, with intolerance to the components of the drug and for the treatment of patients under six years of age.

• Essential phospholipids

Essentiale is prohibited in case of hypersensitivity to its active substances. The solution for injection is not prescribed to newborns and premature babies, since benzyl alcohol is included in the composition of the product.

• Animal products

Hepatosan has the only contraindication - intolerance to the active components.

• Amino acids

Ursosan is not prescribed to patients with acute inflammatory lesions of the bile ducts and gallbladder, as well as in violation of contractile function. Tablets are not prescribed for calcified stones and biliary colic, impaired renal and liver function. The use of the drug in pediatric practice is possible for patients older than 5 years.

• Biologically active additives

Liv 52 is not used for intolerance to its components, during pregnancy and lactation. It is used with extreme caution in diseases of the gastrointestinal tract and for the treatment of children with pathologies of the biliary tract.

Side effects

Non-compliance with medical recommendations for the use of tablets leads to undesirable effects. Side effects of drugs for the liver are manifested by many organs and systems. Most often, these are allergic reactions: skin itching, rash, redness.

Gastrointestinal and cardiovascular disorders are possible. Patients complain of headaches, dizziness. Most hepatoprotectors and essential phospholipids are well tolerated, but only if the prescribed dosage and duration of therapy are observed.

Medicines for the liver after alcohol

Alcohol destroys liver cells not only in chronic alcoholics, but also in those who like to drink alcohol from time to time. But the situation is fixable, since the body has the ability to recover. There are many medicines that will help normalize the functioning of the liver and accelerate the regeneration of damaged cells.

The best medicines for the liver after alcohol:

• Restoring - this category includes hepatoprotectors, agents with essential phospholipids. Most often used: Essentiale, Phosphogliv, Essliver.
• Preparations (catalysts) for activating regeneration are vitamin complexes with amino acids that create an environment for the formation of new hepatocytes. This category includes: D i Guard, Dipana.
• Cleansers - facilitate the work of the body, remove toxins and eliminate signs of intoxication. Patients are prescribed: Karsil, Gepabene, Heptral, Silimar.

All of the above medicines can be used only for medical purposes. After diagnosing the patient's condition, the doctor selects the optimal medicine, determines the required dosage and duration of therapy. But the main rule of treatment after alcohol damage is a complete rejection of alcohol.

Medicines to restore the liver

Many drugs are used to restore the liver. They may have a plant base, animal liver enzymes, or amino acids and essential phospholipids. There are also combined means of complex action. It is impossible to name the best remedy, because for each case there is an optimal drug.

Medications to restore the liver:

• Biologically active additives - Artichoke extract, Heptralight, Liposil, Hepatrin.
• Tablets and capsules - Enerliv, Essliver forte, Karsil, Liv 52.
• Homeopathic remedies - Galsten drops, Hepel tablets.

For recovery, you can use not only pharmacological agents, but also methods of traditional medicine. For example, aromatherapy with anise, rosemary, juniper and other essential oils. The recipe for pumpkin with honey is especially popular and has a healing effect. A ripe vegetable must be washed, cut off the top and cleaned the seeds. Pour honey inside and close with a cut top. Leave the vegetable to infuse at room temperature or in a cool place for 10 days. After this period, drain the honey and take 1 spoon 2-3 times a day. The course of such therapy is 1-2 months.

, , , ,

Medicines for liver cleansing

Many people face such a problem as liver disease. The body's main filter ceases to fully cope with its functions, causing disturbances from other organs and systems. To eliminate the pathological condition, as a rule, plant-based preparations are used. Such tools allow you to adjust the enzyme activity, minimize the effects of toxins and increase resistance to the negative effects of harmful substances.

The main list of drugs for cleansing the liver:

• HeptraLight - contains a metabolically active substance, effectively removes toxins. For treatment, take 200 mg 1 time per day.

• Liposil is a preparation based on milk thistle extract and soy phospholipids. To cleanse the liver, take 1-2 capsules per day.

• Bonjigar - active ingredients: chicory, nightshade, barberry, white eclipta. The product is available in the form of gelatin capsules and syrup. For cleansing, take 1-2 capsules or 15 ml of syrup 3 times a day after meals.

• Allohol - contains condensed bile, activated charcoal, nettle and garlic extract. Enhances the synthesis of bile acids and bile. You can take 1-2 tablets 3-4 times a day.

• Silymarin - this substance is part of many drugs. Favorably affects hepatocytes, accelerates the excretion of bile. For treatment, take 200-300 mg per day.

Magnesium is used to cleanse the liver and gallbladder. This substance increases the acidity of the stomach and has a powerful choleretic effect, so it can be used only with the permission of a doctor. To prepare the medicine, dissolve 2 tablespoons of magnesia in a glass of boiled water and drink the solution 30-40 minutes before meals. Before and after taking the remedy, it is recommended to lie down for 1-2 hours on the right side.

Read the full list of drugs for liver cleansing.

Medicines for the liver after antibiotics

Antibiotics are used to eliminate many diseases. Their long-term use negatively affects the health of all organs and systems. Medicines for the liver after antibiotics restores the filter, since it is he who removes the decay products of drugs, toxins and other harmful substances from the body.

To restore the body, special means are used - herbal remedies, that is, hepatoprotectors. The most popular medicines:

• Medicines with herbal ingredients and milk thistle - Karsil, Liv 52, Galstena, Gepabene, Ovesol. They stabilize cell membranes and have an antioxidant effect.
• Essential phospholipids - Essentiale forte, Essliver, Phosphogliv. Accelerate regeneration processes, have an antifibrotic effect.
• Means with ursodeoxycholic acid - Ursolfak, Ursosan. They protect cell membranes, eliminate the inflammatory process and accelerate the excretion of bile.

For treatment after antibiotics, folk remedies are excellent. But do not forget that such methods are auxiliary therapy, that is, an addition to the main treatment.

• Take milk thistle, corn stigmas and chicory in equal proportions, pour 200 ml of boiling water over them. The broth should be infused for 10-12 hours, after which it must be filtered and taken before meals.
• Pour 2 cups boiling water over chicory flowers and simmer for 20-30 minutes. Strain the medicine, add a couple of slices of lemon and a spoonful of honey, use as tea.
• Finely chop 1 kg of cabbage, add currants or lingonberries, kiwi and orange to it. Toss the salad well and make a dressing of lemon juice, olive oil, spices and apple cider vinegar. Eat salad throughout the week with a piece of black bread.

Medicines for the liver in ampoules

To eliminate diseases of the liver and digestive tract, many drugs are used in different forms of release. Focusing on the results of tests and diagnostics, the course of the disease and the characteristics of the patient's body, the doctor selects the best therapy option.

Medicines for the liver in ampoules:

1. Heptral

Hepatoprotector with antidepressant activity. It has choleretic, cholekinetic, antioxidant, regenerating, neuroprotective effects. The active substance, ademetionine, compensates for its deficiency in the body and takes part in the biological reactions of transmethylation. Increases the content of glutamine in the liver, normalizes metabolic reactions and has a choleretic effect.

• Heptral is prescribed for the treatment of hepatitis of various etiologies, cholecystitis, cholangitis, cholestasis, toxic lesions. Intravenous administration is indicated for fatty degeneration, cirrhosis, encephalopathy, withdrawal syndrome. Ampoules are used intramuscularly or drip intravenously. The daily dosage should not exceed 800 mg.
• It is contraindicated to use in the I-II trimesters of pregnancy and during lactation. Do not prescribe for patients under 18 years of age and with individual intolerance to the components. Side effects appear when the recommended dosage is exceeded. Most often these are allergic reactions and dyspeptic disorders, gastralia.

1. Essentiale N

Solution for intravenous administration from the pharmacological group of hepatoprotectors. The active substance is essential phospholipids 250 mg. The active ingredient regulates the metabolism of lipoproteins and increases their binding to cholesterol. It has a detoxifying, restoring effect, prevents the formation of connective tissue in the liver.

• Used only for intravenous administration, intramuscular injections can cause local allergic reactions. For breeding use 5-10% dextrose solution. The resulting solution should be clear at the time of administration. The use of electrolyte solutions (Ringer's solution, isotonic) for dilution is contraindicated.
• Indications for use: hepatitis, fatty degeneration, cirrhosis, toxic lesions and necrosis of liver cells. It helps with toxicosis during pregnancy, hepatic coma and precoma, with radiation syndrome and psoriasis, in the pre and postoperative period.
• The use of this drug during pregnancy is possible only for medical purposes, since gasoline alcohol penetrates the placental barrier and adversely affects the development of the fetus. It is not used to treat patients under 3 years of age and with hypersensitivity to the components. Side effects are manifested by the immune system, causing allergic reactions and itching.

1. Remaxol

Balanced infusion solution with hepatoprotective properties. Produced in glass bottles of 400 ml. Active ingredients: succinic acid 5.28 g, meglumine 8 g, riboxin 2 g and other components. The drug reduces the content of bilirubin and its fractions, minimizes the activity of excretory enzymes of hepatocytes and oxidizes cholesterol, converting it into bile acids.

• The main indications for use: liver dysfunction in toxic, drug and alcoholic hepatitis. Comprehensive treatment of viral hepatitis. With drip administration, the active components quickly spread through the tissues of the body. The daily dosage is 400-800 ml, the rate of administration is 2-3 ml / min.
• It is contraindicated to use during pregnancy and lactation. Do not prescribe to patients of childhood and with individual intolerance to the components. Under medical supervision, it is used for gout, nephrolithiasis and hyperuricemia. It is not recommended to mix in one vial with other means for intravenous administration.
• In case of an overdose, side effects are possible. With the rapid introduction of the solution, there is a feeling of heat, dryness and sore throat, hyperemia of the skin. Allergic reactions, nausea, headaches, vomiting, dizziness are possible. If these symptoms appear, you should seek medical help to adjust the dose.

1. Laennec

Immunomodulator, available in ampoules for injection. Stimulates humoral immunity, increases the activity of phagocytes, increases the bactericidal activity of leukocytes. Active components stimulate the regeneration of damaged cells, prevent the deposition of cholesterol and lipids.

• Injections are prescribed to eliminate chronic liver diseases of various etiologies. The medication helps with atopic dermatitis and chronic recurrent herpes. In case of liver pathologies, 2 ml per day is prescribed intravenously. The maximum dosage should not exceed 10 ml per day. The course of treatment takes 2-3 weeks.
• It is contraindicated to use for patients of childhood, during pregnancy and lactation. If these recommendations are not followed and the prescribed dosage is exceeded, side effects are possible. Most often, these are painful sensations and numbness at the injection site, allergic reactions.

1. Cryomelt MN

Solution for injection, hepatoprotector. The active ingredient is honey, available in ampoules of 1 ml. The drug is a sterile native solution of honey in water, prepared using a special technology. It has an antioxidant effect and stabilizes the membranes of damaged cells. Hepatoprotective activity provides protection against the negative effects of toxins and harmful substances.

• Cryomelt is prescribed for the treatment of chronic hepatitis and toxic lesions, as well as for fatty degeneration of various etiologies. Patients are administered 1 ampoule per day, the course of treatment is 10-20 days.
• Contraindicated in case of hypersensitivity to bee products and for pediatric patients. It is used with extreme caution by patients with diabetes mellitus. Side effects are manifested as allergic reactions of varying severity.

Liver Medicines for Children

Treatment of any diseases in pediatric patients requires a professional medical approach. Children are prescribed safe drugs with minimal side effects and contraindications.

Consider effective liver medicines for children:

• Galstena is a herbal homeopathic remedy. It has hepatoprotective, anti-inflammatory, choleretic and antispasmodic properties. It is used for the complex therapy of pancreatitis, liver restoration, after prolonged use of antibiotics, with hepatitis and other pathologies. Available in drops, which allows it to be used for the smallest patients.

• Essentiale - the active ingredients of this medication are essential phospholipids. In their structure, they are similar to the endogenous membranes of liver phospholipids. It is prescribed for fatty degeneration, acute and chronic hepatitis, organ cell necrosis and toxic lesions. Available in capsule and injectable form for intravenous administration.

• Allochol is a drug that enhances the formation of bile. It improves the secretory function of the gastrointestinal tract, reduces fermentation processes in the intestines, accelerates the regeneration of damaged liver and gallbladder cells. It is prescribed for the treatment of chronic hepatitis, with cholecystitis, cholangitis, prolonged constipation associated with intestinal atony. Available in the form of enteric-coated capsules.
• Antral is a hepatoprotector, used to treat hepatitis of various etiologies and minimizes signs of dyspeptic and asthenovegetative syndrome. Assign for the treatment of cirrhosis and fatty degeneration, various inflammatory and infectious diseases of the digestive tract. Antral is available in the form of capsules for oral administration.

• Betargin - contains amino acids (betaine, arginine) necessary for the normalization of the functions of the hepatobiliary system. Available in the form of a solution for oral administration. It is used to treat functional disorders of the liver, with hepatosis, viral hepatitis, steatosis, drug and toxic damage to the organ.

Method of application and dosage of drugs for the liver

In order for the treatment to be quick and effective, the doctor prescribes to the patient the method of administration and dose of drugs. For the liver, drugs of different form are used, so the therapeutic effect depends on the method of their use.

• Herbal hepatoprotectors

Gepabene is prescribed 1 tablet 2-3 times a day. If pain in the right hypochondrium appears at night, then an additional capsule is allowed at bedtime. The maximum daily dose is 6 tablets in 3 doses, the duration of therapy is from 3 months.

• Essential phospholipids

The daily dose of Essentiale is 4-6 tablets in 3-4 doses, the duration of treatment is individual for each patient. Tablets are taken without chewing, washed down with water. The dosage of the solution for intravenous injection is up to two ampoules per day.

• Animal products

Hepatosan is taken at 200-400 mg, depending on the indications. The course of treatment is 10-20 days.

• Amino acids

Ursosan is taken at the rate of 10 mg/kg of body weight. The daily dosage is divided into 2-3 doses. For patients under 2 years of age, the dosage is selected individually.

• Biologically active additives

Liv 52 is taken both for therapeutic and prophylactic purposes. For children over 6 years old and adults, 1-3 tablets 2-3 times a day. Drops are used to prevent liver diseases, 10-20 drops 2 times a day for children over 2 years old and 80-160 drops for adults.

Overdose

High doses of the drug may cause adverse symptoms. An overdose manifests itself as an increase in side effects. Most liver medicines are well tolerated. In rare cases, there are signs of disorders of the gastrointestinal tract, headaches.

Interactions with other drugs

The use of several drugs in the elimination of one disease is possible only with the appropriate medical prescription. Interaction with other drugs depends on the form of release of the main drug.

Injections for intravenous and intramuscular administration must not be mixed with other drugs. Since local allergic reactions, redness at the injection site and other symptoms are possible. Particular attention should be paid to solutions for diluting ampoules. In any case, when using several drugs at the same time, it is necessary to observe a time interval of 1-2 hours to prevent side effects.

Best before date

Medicines for the liver help to restore the cells of the damaged organ and improve its functioning. Such medicines are used in the treatment of patients of all ages. In order for the treatment to be safe and effective, before using the drug, it is necessary to study its instructions and pay attention to the expiration date. The use of expired tablets or injections threatens with side effects, disrupts the work of all organs and systems.

Medicines for the liver are hepatoprotectors that are prescribed by a doctor for various violations of liver function, hepatitis (viral, toxic,), with liver damage when taking drugs that have a negative effect on its cells (antitumor, painkillers, anti-tuberculosis drugs, broad-spectrum antibiotics , and etc).

What medicine for the liver is considered the best, good, effective and not expensive? What drug restores the liver, is used for prevention, to maintain the liver? To date, the pharmaceutical industry offers a lot of pills, ostensibly to restore the liver:

• amino acid derivatives
• phospholipids
• bile acids
• herbal remedies
• preparations of animal origin
• homeopathic preparations

but the ideal medicine for the treatment of the liver, which quickly and effectively restores its tissues, has not yet been created. According to the doctor's prescription, hepatoprotectors are taken during the entire adverse effect of provoking factors, as well as after the end of their influence. It should be noted that a one-time medication for the liver after alcohol, heavy feast, overeating, taking toxic drugs does not give any effect.

When are hepatoprotectors needed?

In Russia, a huge selection of hepatoprotectors is presented, and these drugs are used very often. Moreover, the cost of the course of treatment costs large sums for patients, and many do not feel the result. Disputes about the need and expediency of such therapy have been going on for a long time, in our country a doctor can prescribe hepatroprotectors in the following cases:

• Viral hepatitis(see) - they are prescribed if antiviral drugs do not help or, for some reason, antiviral treatment is not possible. Hepatoprotectors in this case can be used for prophylaxis in complex treatment.
• Alcoholic hepatitis threatened by cirrhosis of the liver- in this case, alcohol should be abandoned, these drugs do not have a significant effect. If alcohol intake continues, whether the patient uses hepatoprotectors or not is not important. No, even the best medicines for the liver will not help if a person continues to drink alcohol.
• Fatty liver disease (non-alcoholic)- in patients with obesity or in patients with type 2 diabetes, fat cells are also formed in the liver, which leads to its destruction (see). In this case, hepatoprotectors are needed to accelerate the effect only with an integrated approach to therapy - a diet that promotes weight loss, increased physical activity, antidiabetic drugs, lowering cholesterol (see).
• Drug-induced hepatitis (toxic), primary biliary cirrhosis- certain hepatoprotectors are prescribed in complex therapy.

It should be understood that it is impossible to restore the liver with drugs alone, you should also follow a diet and limit alcohol intake, quit smoking, and treat concomitant diseases, since the patient often has impaired functions of other organs involved in digestion - the gallbladder, pancreas.

Why are hepatoprotectors as a class of medicines available only in Russia and the CIS countries?

The class of medicines "hepatoprotectors" exists only in Russia and the CIS countries, neither in Europe, nor in North America, nor in Australia, most of them are registered. They are not included in the lists of tablets for the treatment of liver diseases due to the fact that their therapeutic efficacy has not been proven and clinical significance has not been confirmed.

Very rarely, some of them are used in the USA and Europe for narrow indications, they are used as dietary supplements (that is, their use does not guarantee an effect). The French company Sanofi, one of the manufacturers of Essentiale, sends 99% of its production to Russia and the CIS countries, since no one in the world needs this drug.

It is worth noting that the pharmaceutical market in the 21st century is a very profitable business, in which there is the same fierce competition as in any branch of the market economy. And today it is very difficult to determine how effective this or that drug is, since research (very expensive) is funded by interested parties.

Preparations for the liver - essential phospholipids

• fatty degeneration of the liver
• liver cirrhosis
• chronic hepatitis
• toxic hepatitis
• alcoholic hepatitis (see)
• radiation syndrome

Is it really? Below we will give two points of view, one - these instructions for essential phospholipids and known efficacy studies, and the other - other information about studies that contradict the advertising campaign of this group of drugs.

positive opinion- What does the instruction for the use of these capsules say? Essential phospholipids (derived from soy) are components of the cell wall of hepatocytes. The action of phospholipids is that they penetrate into the lipid layer of the walls of damaged cells, improving their functions.

Many believe that essential phospholipids are able to restore liver cells, this is not entirely true, since their action only improves the condition of cell walls. When taking phospholipids, the energy costs of the liver are reduced, enzyme activity is increased, and the physicochemical properties of bile are improved. To obtain a tangible result, these tablets should be taken for a very long time (up to six months). The greatest effect is achieved with intravenous administration of Essentiale Forte.

By the end of 2001, there were 186 clinical trials, including more than 11,000 patients, which allow us to draw conclusions about the effectiveness of these drugs. Essential phospholipids increase the likelihood of a response to α-interferon (c), are well tolerated by patients, and reduce the frequency of relapses after completion of α-interferon therapy.

negative opinion— Initially, it was assumed that essential phospholipids are effective as a "drug cover" when taking hepatotoxic drugs, with alcoholic, viral hepatitis and liver steatosis of various origins.

However, a 2003 US study of veteran medical centers, did not reveal any positive effect of these drugs on liver function. In addition, it was found that against the background of viral hepatitis, both acute and chronic, the intake of essential phospholipids contributed to the activation of inflammation, as it provoked bile stasis. Based on these studies, their use in the treatment of viral hepatitis is not advisable.

Moreover, it is known that various B vitamins that are added to some products (Essliver Forte) are not recommended to be taken at the same time (see). According to some sources, liver pills like Essentiale hardly get into the liver, but are distributed and metabolized throughout the body, which casts doubt on their effectiveness. But the cost of treatment with these drugs is very high - only for a monthly course of treatment (in capsules) an adult needs more than 3,000 rubles.

Conclusion: Now in clinical practice, essential phospholipids are widely used in non-alcoholic steatohepatitis, toxic liver damage, as a cover when taking hepatotoxic drugs, but the effectiveness remains in doubt. In addition, with active hepatitis, their use requires caution, or refusal to use, since this can enhance the activity of the process and increase cholestasis.

List of essential phospholipids

Essentiale N, Essentiale forte N Ingredients: essential phospholipids. Side effects: well tolerated, sometimes diarrhea, abdominal discomfort. Contraindicated in children under 12 years of age. Average price in pharmacies 2018: 30 pcs. 660 rubles, 5 amp. 950 rub. 90 pcs. 1300 rub.

Essliver Forte Ingredients: essential phospholipids (less than in Essential), vitamins (B1, B2, B6, E, PP, B12) Side effects: possible diarrhea, pain in the upper abdomen With caution in children under 1 2 years old, pregnant, lactating. Price: 30 caps. 300 rubles, 50 caps. 420 rub.

Ingredients: Lipoid C100 and Silymarin () Price: 30 caps. 420-480 rub.

Gepaguard Active Ingredients: essential phospholipids, vitamin E Price: 30 caps. 300 rubles, 120 caps. 900-950 rubles.

Ingredients: phospholipids, trisodium salt of glycyrrhizic acid (antiviral and immunomodulating effect) Price: 50 caps. 450-500 rub. powder for injections 5 pcs. 1300-1500 rub.

Resolution PRO Ingredients: Lipoid PPL 600, which contains: medium chain triglycerides, phospholipids, glycerol mono/dialconate, soybean oil, vitamin E. Price: 30 caps. 450 rubles, 100 caps. 1300 rub.

Doppelherz active essential phospholipids Compound: Essential phospholipids, Vitamin B1, B2, B6 Price: 60 caps. 460 rubles, 5 amp. 640 rub.

Eslidine Composition: phospholipids + methionine Indicated: For liver diseases, diabetes mellitus, psoriasis, dystrophy and exhaustion, atherosclerosis of the coronary arteries and brain vessels . Contraindicated: children under 3 years of age, pregnant and lactating with caution. Price: 580 -720 rubles.

Tablets - bile acids

Ursodeoxycholic acid is a bile acid preparation. It is used for the treatment of diseases of the biliary tract and liver, uncomplicated cholelithiasis. It has a hypoglycemic effect, choleretic, therefore it is contraindicated in the presence of X-ray-positive (high in calcium) gallstones (see also), reduces the saturation of bile with cholesterol (until cholesterol stones are completely dissolved), causes an increase in pancreatic and gastric secretion. Affects immunological reactions in the liver - reduces, affects the formation of interleukin-2, the number of T-lymphocytes.

Since drugs containing ursodeoxycholic acid have a number of serious contraindications (acute inflammatory processes in the intestines, gallbladder, severe dysfunction of the pancreas, kidneys and liver, gallstones), and also have an immunomodulatory effect - they use without a doctor's recommendation is dangerous.

These drugs are used for:

• biliary reflux gastritis,
• for symptomatic treatment of primary biliary cirrhosis,
• to dissolve cholesterol stones in the gallbladder,
• alcohol, toxic liver damage,
• acute hepatitis, with hepatopathy of pregnant women.
• UDCA is the most effective treatment for primary biliary cirrhosis, primary sclerosing cholangitis.

Pathogenetic therapy with ursodeoxycholic acid is carried out in patients with viral hepatitis with aggravating factors - during pregnancy, alcoholic-viral liver damage, hemophilia, in adolescence, with oncohematological diseases, drug and substance abuse.

10 caps. 250 rub, 50 caps. 1000 rub. 100 caps. 1800 rub, susp. 1200 r.	Exhol 10 pcs 200 rub 100 pieces. 1500	Urosliv 10 caps. 160 rubles, 100 caps.1300 rub.	100 caps. 1100 rub.
Grinterol 50 pcs. 700 rub 100 pcs 1400 rub.	100 caps. 1200 rub.	50 pcs.300 rub. 100 pieces. 900r.	10 caps. 200 rub. 100 caps. 1500 rub.

Tablets for the liver of animal origin

Positive opinion: There are literally two such tablets for the liver - Sirepar and Hepatosan, they are not used for prevention, they are dispensed by prescription, are used only for the treatment of liver diseases according to indications (cirrhosis, hepatitis, drug-induced and toxic hepatitis). They are produced from pig liver cells (Hepatosan) and from cattle liver hydrolyzate (Sirepar), contain amino acids, cyanocobalamin, low molecular weight metabolites and fragments of liver growth factors. It is believed that these tablets for the liver have a hepatoprotective effect, detoxification, antioxidant properties, stimulate the regeneration of the liver parenchyma.

There is also a complex preparation Progepar (composition: inositol, cyanocobalamin, liver extract KPC N (liver hydrolyzate), cysteine ​​hydrochloride), improves blood flow in the liver tissue, restores the structure of hepatocytes, stops the formation of connective tissue in the liver, improves functional indicators of liver function, increases diuresis . It is used in the complex treatment of chronic hepatitis, cirrhosis, fatty degeneration of the liver, radiation sickness, drug intoxication.

Negative opinion: There is no evidence base to support their clinical efficacy and safety. Moreover, taking these drugs is potentially dangerous:

• It is impossible to prescribe them to patients with active forms of hepatitis, since the phenomena of immunopathological, mesenchymal-inflammatory and cytolytic syndromes may increase.
• These drugs have a high allergenic potential, therefore, before starting treatment, it should be determined whether there is an increased individual sensitivity to the drug.
• The use of bovine liver hydrolysates increases the risk of a patient becoming infected with a prion infection that causes spongiform encephalopathy (a fatal neurodegenerative disease - Creutzfeldt-Jakob disease). At the end of the 20th century, interest in this pathology arose when iatrogenic transmission of prions was proven in 250 patients with spongiform encephalopathy when contaminated gonadotropin was administered.

Due to the potential danger and unproven efficacy, drugs of this group are not advisable to use for the treatment of liver pathologies.

Treatment of the liver with amino acids

Ademetionine - Heptral, Heptor

positive opinion– Amino acids, for example, ademetionine, take part in the synthesis of biologically active substances and phospholipids, have regenerating and detoxifying properties. Heptral by the end of 1 week of use also exhibits a pronounced antidepressant effect, breaks down fats and promotes their removal from the liver. These drugs are used for fatty liver hepatosis (fatty degeneration), chronic hepatitis, toxic hepatitis, withdrawal symptoms, and depression.

The analysis of the conducted clinical studies indicates the clinical efficacy of ademetionine and indicates a pronounced hepatoprotective efficacy in alcoholic and drug-induced liver damage, cholestatic liver diseases (primary biliary cirrhosis), and chronic viral hepatitis. It has choleretic and cholekinetic effects, antioxidant, neuroprotective and antifibrosing properties.

negative opinion- as a drug Heptral is registered in Germany, Italy, Russia. In Australia, it is registered as a drug for animals (veterinary), in other countries, as a dietary supplement, since studies have shown a dubious effect.

Practicing doctors - gastroenterologists, infectious disease specialists, hepatologists know that this drug very effective, but only with intravenous infusions, since only a small part of the drug is absorbed when taken orally. Therefore, Heptral in tablets with serious liver pathology is an almost useless waste of money, in contrast to intravenous use.

Ingredients: active ingredient ademetionine It has an antidepressant, regenerating, antioxidant effect. Slows down the development of cirrhosis of the liver. Side effects: may be heartburn, stomach pain. Price: 20 tab. or 5 fl. 1700 -1800 rub.

Ingredients: active substance ademetionine As well as Heptral is indicated for toxic liver damage, depression, cirrhosis of the liver, treatment of the consequences of alcohol abuse. Contraindicated: children, lactation and in the I and II trimester of pregnancy. Price: 20 tab. 800-1000 rubles, 5 fl. 1200 rub.

Ornithine aspartate - Hepa-Merz

positive opinion- Ornithine helps to reduce high levels of ammonia, is used for violations of brain functions associated with impaired liver function, as well as for fatty degeneration and toxic hepatitis. For prevention, this medicine is practically not used.

The effectiveness of Hepa-Merz has been proven in a randomized multicenter study in patients with cirrhosis of the liver with elevated levels of ammonia in the blood. It is prescribed for various types of hepatitis, non-alcoholic steatohepatitis, especially for hepatic encephalopathy and cirrhosis of the liver.

negative opinion- this drug was widely advertised, but with alcoholic liver damage it has practically no effect, it makes no sense to use it for the prevention, protection, restoration of the liver. The only time when its use gives a tangible effect is with a hepatic coma for a short-term exit from it, since ornithine binds components toxic to the brain in the blood.

Thioctic acid

Action: normalizes lipid, energy, carbohydrate metabolism, has hepatoprotective, antioxidant properties. Helps reduce blood glucose levels, is used in the complex treatment of hepatitis and toxic liver damage.
Contraindications: children, can lead to a sharp decrease in blood glucose levels (especially in diabetics).
Side effects: nausea, vomiting, diarrhea, pruritus, headache.

Complex hepatoprotector - Remaxol, infusion solution

Prevention of the hepatotoxic effect of alcohol

Medicines for the liver of plant origin

Medicines for the liver with milk thistle - Legalon, Karsil, Gepabene, Silimar

Positive opinion:- these drugs are widely used and really effective (see). When asked which medicine is best for the liver, the answer is milk thistle preparations. Silymarin is the collective name for the biologically active substances of the fruits of milk thistle, is a strong antioxidant (and the only antidote for poisoning with pale toadstool). According to the indications, it is prescribed for hepatitis and other liver diseases with a course of at least 3 months, helps to reduce the intensity of the progression of liver cirrhosis. Preparations with the active ingredient silymarin are a good medicine for recovery, maintenance of the liver, as it stimulates the growth of new cells and restores the destruction of cell membranes.

For more effective treatment, it is better not to save money, but to take Legalon with a purer chemical substance and a higher dosage (70 and 140 mg) or Karsil Forte (90 mg) than simple Karsil (35 mg).

In pharmacy chains, there is a fairly wide selection of preparations with milk thistle, both medicines and dietary supplements. Among the analogues of Karsil, one can single out Silimar tab., Legalon, Silibinin, Silymarin, among dietary supplements - milk thistle meal, milk thistle oil, capsules.

negative opinion: Despite the safety of this agent, the clinical efficacy of silymarin in alcoholic liver damage and acute hepatitis has not been confirmed due to a lack of adequate studies. In acute viral hepatitis B, there was no improvement in liver function between the placebo and silymarin groups (see). Data on the effectiveness of its use in acute hepatitis C have not yet been obtained, there are only descriptions of individual cases when milk thistle extract reduced the activity of aminotransferases in chronic hepatitis C. Summarizing today's data from evidence-based medicine on its effectiveness, we can state that today experimental data to recommend further study of the effectiveness of silymarin in chronic liver diseases (including fatty liver).

Karsil (35mg) and Karsil Forte (90mg) Ingredients: milk thistle extract. Application: before meals, drinking plenty of water, the course is at least 3 months. For prevention, 1 tablet 3 r / day. For children over 12 years old and adults with severe liver damage, 4 others 3 r / day, then 1-2 dr 3 r / day. Side effects Karsil 80 pcs. 330 rub., Karsil Forte 30 pcs. 380 rub.

Ingredients: milk thistle fruit extract. Application: after eating, without chewing, drinking a small amount of liquid. The beginning of treatment for 2 caps. 3 r/day, maintenance therapy 1 dr. 3 r/day. Side effects: allergic reactions, diarrhea. Legalon 70 mg: 30 caps. 230 rub. 60 caps. 400 rub Legalon 140 mg: 30 caps - 340 rubles, 60 caps. 600 rub.

Gepabene (milk thistle and fumes) Ingredients: herbs of fume medicinal dry extract and milk thistle. Contraindication: children under 18 years old, acute inflammation of the liver and biliary tract. Application: 1 caps. 3 r / d. In case of pain syndrome, additionally take 1 more caps. before bedtime. The maximum daily dose is 6 capsules, taken in 3-4 doses. Price: 30 caps. 430-570 rub.

Silimar tablets Ingredients: milk thistle fruit extract. Application: with toxic liver damage, cirrhosis, after hepatitis, chronic hepatitis, with prolonged use of alcohol and drugs, with intoxication. 1-2 tab. 3 r / d in 30 min. before meals. The course is 25-30 days. After 1-3 months, you can repeat the treatment. Not recommended children under 12 years old. Side effects: loosening of the stool and allergic reactions are possible. Price: 30 pcs. 110-150 rub.

Milk thistle tablets (extract) Ingredients: 50 mg silymarin. Application, indications, contraindications and side effects the same as in other preparations with milk thistle extract. Price: 20 pcs. 130 rub.

Milk thistle meal (ground plant) Application: 1 teaspoon 3 r / day with meals. Contraindications: cholelithiasis, exacerbation of gastric and duodenal ulcers, hypersensitivity, pregnant, lactating women. Side effects: pain in the right hypochondrium, diarrhea, allergy. Price: 60 rubles.

Milk thistle oil capsules Application: adults 1 caps. 2 r / d during meals. The course is 1 month, which can be repeated 2-3 times a year. Contraindications Key words: acute gastrointestinal diseases, childhood. Price: 40-60 rubles

milk thistle syrup Ingredients: meal and milk thistle extract, common thyme herb, common tansy flowers. Application: 1 tbsp. spoon 1-2 r / d during meals. Course 4-6 weeks. It is possible to repeat the course up to 4 times a year. Contraindications: children under 14, pregnancy, lactation, diabetes mellitus. Price: 150 ml. 110 rub.

Artichoke is a plant used to treat the liver

positive opinion: Artichoke is a plant that has been used in folk medicine since ancient times to reduce joint pain, to treat jaundice, as it improves metabolism, helps reduce bad cholesterol, has a diuretic, choleretic and hepatoprotective effect. In artichoke preparations, the main active ingredient is cymarin, similar in properties to silibinin. Among preparations with artichoke, Hofitol can be distinguished, among dietary supplements - Cynarix, Artichoke Extract. They are used to relieve alcohol intoxication, for the treatment of cholecystitis, hepatitis,. The drug has low toxicity and is indicated for liver cirrhosis and toxic hepatitis.

Negative opinion: As a hepatoprotector, artichoke leaf extract is widely used, but no evidence-based efficacy studies have been conducted, and it is not recommended for use in acute hepatitis, cholelithiasis and cholestasis syndrome.

bottle 350-400 rubles, 60 tab. 300 rub. 180 tab. 600-700 rub.	Solgar Artichoke leaf extract Price: 60 caps. 1100 rub.
Artichoke Price: 20 tab. about 120 rubles.	Price: 60 tab. 360 rub.

Medicine for the liver - Liv 52, and other dietary supplements

positive opinion- the manufacturer of Liv 52 claims that the extracts of medicinal herbs that make up the drug protect the liver parenchyma in case of toxic damage (drugs, alcohol), normalize the protein-synthetic function of the liver, have a choleretic effect, stimulate the restoration of liver cells, have a slight antioxidant effect, restore the ratio of some phospholipid fractions. It is used for hepatitis, anorexia, for the prevention of liver diseases, cirrhosis. Studies conducted in Russia have shown the effectiveness of using Liv 52 in the treatment of hepatitis A in children, the results were published in an article by experts from the Research Institute of Pediatrics and Pediatric Surgery in Moscow.

negative opinion- however, according to the results of various US studies, the claimed actions of Liv 52 are not noted. For example, in viral hepatitis, taking Liv 52 did not lead to a reduction in the duration of treatment, but there was a decrease in bilirubin in the blood and a reduction in severe weight loss in patients. In the treatment of alcoholic hepatitis, neither antitoxic nor restorative effect was found. Moreover, the results of one of the clinical studies conducted in the United States led to the withdrawal of this drug from the country's market. In the treatment of alcoholic hepatitis while taking Liv 52, the survival rate in the placebo group was 86%, and in the group taking Liv 52 - 74%. In acute liver pathologies, the use of these tablets for the liver aggravated the severity of the inflammatory syndrome.

As for the use of dietary supplements intended for the treatment of liver diseases, its purification, normalization of digestion, this remains the choice of the patient, whether he believes the manufacturer's assurances or not. Since the safety and quality of each series of food supplements can only be confirmed by the manufacturer - a "piece of paper" (certificate of quality), and what will be written there and whether it corresponds to reality is on his conscience. However, there are dietary supplements, the manufacturers of which, taking care of the promotion of the product, confirm their medicinal properties, a positive effect on health by various laboratory and clinical studies, but there are only a few such manufacturers.

Among dietary supplements containing extracts of medicinal herbs, one can distinguish Hepatotransit, Milona 10, Ovesol, Dipana, Hepatrin.

The composition includes aqueous extracts of 10 plants. Price: 48 pcs. 220 rub.

Liv 52 contains extracts of 7 medicinal plants. Price: 100 pcs. 200-250 rub.

as part of silymarin, lecithin, vitamins E, B6, B1, B2, essential phospholipids. Price: 30 pcs.200 rub. 60 pieces350 rub.

contains oat grass, agrimony, voladushki, corn stigmas, powdered lemon juice. Price: 100 rubles.

dandelion roots, burdock, elecampane, artichoke extract, corn silk. Price: 400 rubles.

as a part of Oat Grass, Turmeric, Volodushka Grass and Roots, Sandy Immortelle, Peppermint. Price: 150-200 rubles.

pumpkin seed oil

Positive opinion: The composition of preparations from pumpkin seed oil includes polyunsaturated and unsaturated fatty acids with a high percentage of oleic, linoleic acids - phytosterols, vitamins C and group B, beta-carotene, essential oils, niacin, which has a hepatoprotective effect. A large amount of tocopherols and carotenoids in the composition of the preparations has an antioxidant effect, the presence of essential phospholipids slows down the process of damage to hepatocyte membranes and gives an additional membrane-stabilizing effect, accelerates the recovery of liver cells. Pumpkin seed oil (Tykveol, Peponen) is recommended for use in chronic liver diseases (hepatitis, cirrhosis).

Negative opinion: There is no evidence base for the clinical efficacy of pumpkin seed oil preparations. To judge the real hepatoprotective activity of this agent, additional studies are required.

Tykveol 100 ml 600 rubles, 50 cap. 260 rub.	Peponen	pumpkin seed oil

Homeopathic preparations for the liver

Positive opinion: Among homeopathic preparations, Hepel (Germany) and Galsten (Austria) can be distinguished. It should be remembered that any homeopathic treatment to obtain a tangible effect must be under the control of a homeopath and long enough. Monopreparations with a special affinity for liver cells - May celandine Chelidonium majus and milk thistle Carduus marianus, according to homeopaths, cover most of the symptoms that occur with liver diseases, they are also used as drugs that support the liver.

negative opinion: Homeopathy has both its supporters and its ardent opponents (they consider their effectiveness simply). Homeopathic remedies do not undergo proper clinical research, therefore, there is nothing to say about the effectiveness of these drugs for the treatment of liver diseases.

In custody

Many patients consider herbal preparations and nutritional supplements to be completely safe and sometimes take them without the knowledge of a doctor and without restrictions. This is a big mistake. During treatment, you should tell your doctor about all the dietary supplements, herbs and medications you are taking, as they can be hepatotoxic and interact with other medications you take.

All medicinal plants have a complex composition and contain, although minimal doses, toxic (poisonous) substances. For example, many Chinese herbs have hepatotoxic properties, leading to acute liver failure. Moreover, control over such herbal products (food additives), even in the United States, where the safety of medicines and products is strictly controlled, is not carried out properly. What to say about Russia. Therefore, the use of any herbal remedies should be treated with caution, keeping in mind their possible hepatotoxicity.

So, drugs with proven effectiveness (to varying degrees) are hepatoprotectors:

• Ursodeoxycholic acid
• Amino acid preparations (ornithine aspartate, ademetionine)
• Silymarin preparations are hepatoprotectors with alleged but unproven efficacy, used in certain conditions
• Essential phospholipids - the question of the effectiveness of their use in capsules remains controversial, intravenous administration is more preferable

Cattle liver hydrolysates should not be used due to the potential hazard to the human body. The remaining herbal remedies cannot be recommended for widespread use in chronic liver diseases yet, since their effectiveness has not been adequately proven.

Ultrasound doctor at the multidisciplinary medical center Yanko Medical.

Participant of international conferences, congresses, seminars devoted to the problems of gastroenterology and internal diseases. Expert and author of articles on the therapy of gastroenterology and hepatology.

The liver in the human body is affected as a result of infection or overload, in the performance of its functions. Therefore, it is important which medicines for liver prevention to use in order to avoid deterioration in health.

Before finding out which pills to drink for the prevention of the liver, we will consider what functions it performs and what effects it undergoes.

A normally functioning organ is involved in the processes:

• metabolism, i.e. influence on the metabolism in the body of hormones, proteins, vitamins, carbohydrates and other elements;
• deposition (accumulation) of undigested fats, proteins, minerals, and so on;
• secretions - the production of bile for digestion;
• detoxification - filter functions, delaying and neutralizing poisonous elements;
• excretion of toxic substances from the body.

Signs that signal kidney disease:

• feeling of fatigue and loss of strength;
• feel discomfort or spasms in the right hypochondrium;
• loss of appetite, nausea;
• the skin has changed color (a yellow tint, pigmentation has appeared).

When choosing which pills are best for prophylaxis for the liver, purchase products with a complex action, because they:

• protect and restore broken cell membranes;
• activate metabolism in each cell;
• normalize the production of bile;
• accelerate the synthesis of enzymes;
• contribute to the removal of toxic substances.

Almost all tablets for the treatment and prevention of the liver contain essential elements that actively affect the functioning of the organ:

• Glycyrrhizic acid has anti-inflammatory, antioxidant, hepaprotective effects. It counteracts cirrhosis and is part of the tablets for the prevention of the liver when drinking alcohol.
• Phospholipids, which are involved in the regeneration of destroyed cells, are prescribed for a long course (up to 3 months) to achieve a therapeutic effect.
• Ursodeoxycholic acids, which have a choleretic effect and contribute to the dissolution and removal of small stones. The best medicine for the prevention of the liver with this element is ursofalk, which is taken only as directed by a doctor.
• Ademetionine is included in all drugs for the liver as a prophylaxis after alcohol, as it restores the activity of the organ after toxic damage.
• Milk thistle extract is the most common natural element with an antioxidant effect, on the basis of which inexpensive medicines for liver prevention are based.
• The extract of fumes officinalis is included in preparations for the prevention of the liver and gallbladder, as it relieves spasms and normalizes the formation of bile.

When comparing a list of drugs for liver prevention by price, the effectiveness of the ingredients and the effect they have should be taken into account in the first place.

Preparations for the prevention and treatment of liver diseases are divided into:

• funds for maintaining the functions of the body while taking medications or medical procedures that adversely affect the liver (for example, during chemotherapy);
• medicines for restoring the body after an illness (hepatitis, hepatic dystrophy, etc.);
• drugs as liver prophylaxis before or after alcohol intake;
• after receiving physical harm to internal organs (injuries, operations).

Help with discomfort. Hepaprotectors are inexpensive drugs for the prevention of the liver, which have a preventive effect. Such pills for the prevention of the liver are sold without a doctor's prescription, as they have a mild effect.

Ovesol

Ovesol produces detoxification and restores the biliary tract. An inexpensive drug for the prevention of liver diseases, as it consists of natural ingredients (immortelle, oats, peppermint, turmeric roots and others). Take 1 tablet or 15-20 drops 2 times daily with meals. Repeat the course of treatment 3-4 times a year for 20-30 days. Contraindicated: pregnant and lactating women, children, persons with hypersensitivity to one of the components.

Stabilin

The drug is made on the basis of natural natural ingredients:

• amino acids that help produce new biologically active substances;
• L-carotene prevents oxygen starvation, increases the secretion of gastric juice;
• L-tyrosine works as a fat burner;
• B vitamins help normalize metabolic processes, participate in cell renewal;
• extracts of artichoke, tryptophan and glycine improve the patency of blood vessels, accelerate metabolic processes.

All components are selected so as to be combined with each other and enhance the action of each other. This provides a mild effect of the drug on the body.
Stabilin drops can be used for the prevention and periodic cleansing of the liver from toxins and toxins. Dissolve 3-5 drops in liquid (water, tea, juice). Take morning and evening.
Thanks to its natural composition, Stabilin has practically no contraindications. Pregnant and lactating women should always consult a doctor before use. The remedy is contraindicated for people with individual intolerance to the components of Stablen.

Stabilin Drops is a new generation hepatoprotector that facilitates and supports the work of the liver. For 1 course, the drug helps protect the liver from destruction. Stabilin drops replenish the supply of vitamins and nutrients.

Essentiale forte N

The drug is made from natural ingredients, practically does not cause negative consequences. It is recommended to take 2 tablets (capsules) 3 times a day (up to 6 tablets) per day. Analogues Essentiale forte N: Antraliv, Livolife, Essliver, Livenciale.

Leviron Duo

The Leviron Duo complex consists of two components:

1. Oil for the liver is taken on an empty stomach 3 times a day, 1 scoop.
2. Drops are taken 30 minutes before meals. Dissolve 10 drops in a glass of water.

The course of application is about a month.
The tool can be used for the complex treatment of liver diseases and for prevention, since many diseases can occur without symptoms in the initial stages. In addition, regularly undergo medical examinations for the timely detection of pathologies.

The composition of the drug includes:

• polysaccharides quickly remove toxins and toxins;
• larch bark extract slows down the aging process;
• mineral-vitamin complex restores metabolic processes, strengthens the immune system.

Not only ordinary patients, but also celebrities leave positive for liver recovery. The supplement helps to solve liver problems in a month. In addition, many users note an improvement in skin condition, normalization of the digestive tract, and increased immunity.

Heptral

Heptral is recommended in case of damage to the organ by alcohol, drugs or toxic substances. The drug has concomitant antidepressant and antioxidant effects. It cleanses the liver and accelerates its regeneration, normalizes the gallbladder. How to take heptral tablets for liver prevention: 2-4 tablets of 400 mg between meals, without chewing. The drug has a number of side effects from the nervous (dizziness, insomnia, headache), digestive system (bloating, diarrhea, nausea, vomiting), etc. Before taking, consult your doctor.

Karsil

Karsil - inexpensive pills for the prevention of liver disease. Allowed for children from 12 years old. Help to remove the effects of hepatitis, cirrhosis, alcohol poisoning. As a preventive measure, take 2-3 tablets a day before meals with water.

Liv 52

Inexpensive and effective medicine for the prevention of the liver - made from plant materials (capers, chicory, yarrow). Recommended for cleansing the body after taking alcohol, antibiotics, oral contraceptives and other drugs. In the instructions for use, Liv 52 is allowed for children from 6 years old. For prevention, take 2 tablets 2 times a day, regardless of meals.

Phosphogliv

The drug Phosphogliv and analogues (hepalin, ursoliv, silegon, etc.). It is prescribed for alcohol damage and fatty liver diseases, viral hepatitis. It contains glycyrrhizic acid and phospholipids, the drug helps restore liver function, has antiviral and immunomodulatory effects. It is recommended to take 1-2 tablets 3-4 times a day with meals with water. The course of admission is up to 3 months. The price of Phosphogliv is from 491 rubles. per pack (50 capsules). Reviews of Phosphogliv claim that the drug has not only a preventive, but also a therapeutic effect.

Drugs for the prevention of the liver and pancreas

Often, liver diseases are associated with damage to other abdominal organs, which are also involved in digestion and body defense.

Phosphalugel

Phosphalugel has an absorbent and antacid effect. Recommended for gastritis, diseases of the biliary tract and liver, peptic ulcer. Instructions for the use of phosphalugel - for adults and children over 6 years old, one or two sachets (no more than 6 sachets per day) 2-3 times a day. The course of treatment is up to two weeks.

tsikvalon

Tsikvalon, which has a choleretic effect, helps to normalize the production of bile and its excretion. Adults and children over 7 years of age are prescribed 2 tablets 3 times a day after meals. Children under 7 years old - 1 tablet. The course of treatment is 1 month, which must be repeated 3-4 times a year.

Preparations for cleansing the liver and kidneys

Preparations for regular cleaning are reliable prevention of the kidneys and liver.

Cheers Lax

Ura Lax is suitable for isolating stones in urolithic pathologies, has anti-inflammatory and antibacterial effects. Take 1 capsule twice daily with meals (preferably in the morning and afternoon).

CystoTransit

CystoTransit is a preparation from a phytogroup based on knotweed, cranberries, chamomile and other medicinal plants, which ensures the dissolution and removal of stones. Take 1 tsp. (5 ml), dissolved in a glass of water (250 ml), 4 times a day. The duration of admission is 20 days. The course is repeated 4 times a year.

Gortex

Gortex is a herbal remedy based on hydrangea root. At the same time it has an antiseptic and analgesic effect. Take 2 capsules 3 times daily with meals. Duration of admission - 1 month. Contraindications: pregnancy, breastfeeding, individual intolerance to the components of the drug.

Holidays and feasts affect more than one organ, so when deciding which inexpensive and effective drug to use for liver prevention, take care of the pancreas and the gastrointestinal system as a whole. For these purposes, a few days before the holiday, take drugs that help stabilize the body:

• Mezim,
• Panzinorm,
• Pancreatin,
• allohod,
• Holosas.

The most effective medicinal plant in this area is milk thistle. It is used in medicines due to the presence of silymarin in milk thistle, a means of protecting and activating the activity and growth of cells. An extract from milk thistle is produced in the form of oil, capsules or other products from the group of dietary supplements.

Legalon

Legalon is prescribed for the prevention of the liver with toxic and medicinal injuries, with chronic hepatitis, cirrhosis, diseases of the biliary tract and gallbladder. Contraindicated only in case of hypersensitivity to one of the components of the composition. Take Legalon 70 1-2 capsules 2-3 times a day, Legalon 140 - 1 capsule 2 times a day.

Silimar

Suitable as a prophylaxis for intoxication of the body when taking drugs and alcohol. Adults and adolescents over 12 years old: 1-2 tablets 3 times a day for 25-30 days. In chronic diseases, repeat the remedy after 1-3 months.

Silymarin

Silymarin is indicated for liver damage by toxins, hepatitis, for correcting disorders of fat metabolism, for the prevention of liver diseases. For preventive purposes, take 70 mg of the drug 3 times a day. Contraindicated in children under 12 years of age, with intolerance to silibinin and analogues. For maximum effect, while taking Silymarin, refrain from drinking alcohol and follow a diet.

Gepabene

To enhance the action, an extract from the fumes is added to the preparations, which relieves spasms and normalizes the passage of bile. With this composition, Gepabene is produced. Take 1 capsule (maximum 6 capsules) within 24 hours at regular intervals.

Hofitol

Artichoke-based products are produced under the names "Bitter Artichoke", Hofitol, etc. The active substance of this plant is cymarin. Eliminates alcohol intoxication and puffiness. Take 2-3 tablets or 2.5-5.0 ml of solution before meals 3 times a day. The course continues for 2-3 weeks.

Vitamins for the liver

For normal functioning of the liver, it is necessary to maintain the work of the organ. For this, take vitamins, phytocomplexes or G epiprotectors.

Popular vitamins for liver prevention with names:

• Chepaguard;
• Gepar active;
• Legalon;
• Rosanol;
• Lipostabil.

Patient reviews for the listed funds for the prevention of the liver are positive, which confirms the effectiveness of the drugs.

In addition to drugs for the prevention and treatment of the liver, decoctions and infusions of medicinal herbs are used.

Infusion of corn stigmas

The most affordable and common composition is made from corn stigmas, which improve the passage of bile and the release of small stones from the ducts. To do this, pour 2 tablespoons of the crushed plant into a glass of boiled water and insist under the lid for at least half an hour. The prepared solution is filtered and drunk in three doses during the day.

Turmeric

Turmeric has a similar effect, which helps repair damaged liver cells. A quarter teaspoon of turmeric is poured with hot water, honey is added to taste (at least 1 teaspoon), stirred until dissolved and the whole glass is drunk at once. Prepare and drink this infusion 3 to 4 times a day.

milk thistle

In folk recipes, milk thistle seeds are used, which are ground in a coffee grinder. For half a liter of water, take 2 tablespoons of seeds ground into flour and boil for a long time over low heat until the liquid is reduced to the volume of a glass. The resulting broth is taken in a tablespoon every hour.

Each treatment with folk remedies is carried out from 2 weeks to 2 months. After that, a break is made for at least a month. Then the treatment is repeated or other medicinal herbs are used.