"Diphenhydramine" in ampoules: instructions for use in adults, dosage, analogues. Diphenhydramine in ampoules (injections): instructions for use Diphenhydramine for injection

Diphenhydramine is a H1-histamine receptor blocker that relieves spasms of smooth muscles, prevents and eliminates allergic reactions of the body and reduces capillary permeability. The drug has antiemetic, local anesthetic, sedative and hypnotic effects.

Release form and composition

Diphenhydramine is available in the form of tablets and solution for intravenous and intramuscular administration.

Tablets are produced in 10 pieces in blister or cellless packaging. One cardboard box contains 2, 3 or 5 packages.

The solution is available in ampoules of 1 ml. One cardboard pack contains 10 ampoules.

The active ingredient in the drug is diphenhydramine.

Indications for use

According to the instructions, Diphenhydramine in tablet form is used for the following conditions:

• Allergic rhinitis;
• Allergic conjunctivitis;
• Itchy dermatoses;
• Serum sickness;
• Chronic urticaria;
• Dermatographism.

As part of complex therapy, Diphenhydramine is used for angioedema, as well as anaphylactoid and anaphylactic reactions.

Tablets as an antiemetic and hypnotic are used for Meniere's syndrome, insomnia, air and sea sickness, and chorea.

According to the instructions, Diphenhydramine in the form of a solution is prescribed as part of complex therapy for the following conditions:

• Quincke's edema;
• Anaphylactic reactions;
• Anaphylactoid reactions;
• Airsickness;
• Seasickness.

Contraindications

The use of Diphenhydramine is contraindicated in children under 7 months of age and in cases of hypersensitivity to the active substance of the drug.

Tablets and solution should also not be used if the following conditions exist:

• Prostatic hyperplasia;
• Bladder neck stenosis;
• Angle-closure glaucoma;
• Epilepsy;
• Stenosing peptic ulcer of the stomach and duodenum.

Diphenhydramine should be used with caution during pregnancy and breastfeeding, as well as with bronchial asthma.

Directions for use and dosage

The drug in tablet form is prescribed to adult patients at a dose of 30-50 mg 1-3 times a day. The duration of the course of treatment is 10-15 days. The maximum single dose is 100 mg, and the daily dose should not exceed 250 mg.

For insomnia, Diphenhydramine tablets should be taken daily half an hour before bedtime, 50 mg.

In the treatment of postencephalitic and idiopathic parkinsonism, a dose of 25 mg three times a day is prescribed at the beginning of treatment. If necessary, the dose is increased to 50 mg 4 times a day.

Dosages for children are selected depending on age:

• Children aged 7 months to one year are prescribed 3-5 mg three times a day;
• For children aged 1 to 3 years, a dose of 10-30 mg per day is recommended, divided into 2-3 doses;
• Children aged 4 to 6 years are prescribed Diphenhydramine tablets at a dose of 20-45 mg per day, divided into 2-3 doses;
• For children from 7 to 14 years old, the recommended dose is 12.5-25 mg up to 3 times a day.

When using Diphenhydramine in the form of a solution intramuscularly, the maximum single dose is 50 mg, and the daily dose is 150 mg.

For intravenous drip administration of the drug, a dose of 20-50 mg is recommended.

When using the solution intramuscularly and intravenously in children, dosages also depend on age:

• Children aged 7 months to one year are prescribed 3-5 mg;
• For children aged 1 to 3 years, a dose of 5-10 mg is recommended;
• Children aged 4 to 6 years are prescribed Diphenhydramine solution at a dose of 10-15 mg;
• For children from 7 to 14 years old, the recommended dose is 15-30 mg.

The drug can be re-administered after 6-8 hours if necessary.

Side effects

The use of Diphenhydramine may cause the following adverse reactions from the central nervous system:

• Headache;
• Dizziness;
• Weakness;
• Drowsiness;
• Confusion;
• Nervousness;
• Sedative effect;
• Loss of coordination;
• Excitation;
• Insomnia;
• Neuritis;
• Tremor;
• Paresthesia;
• Anxiety;
• Euphoria;
• Cramps.

From the digestive system, Diphenhydramine may cause the following side effects:

• Nausea and vomiting;
• constipation or diarrhea;
• Epigastric pain;
• Dryness of the oral mucosa;
• Anorexia.

The use of Diphenhydramine in some cases may cause the development of side effects from the cardiovascular system, such as decreased blood pressure, tachycardia, palpitations, and extrasystole.

On the part of the sensory organs, while using the product, vertigo, visual impairment, acute labyrinthitis, diplopia and tinnitus are possible.

Sometimes the drug causes the following allergic reactions:

• Anaphylactic shock;
• Hives;
• Photosensitivity;
• Drug rash.

The hematopoietic organs may react to Diphenhydramine with thrombocytopenia, hemolytic anemia or agranulocytosis.

From the genitourinary system, when using the drug, urinary retention, difficulty or frequent urination, or early menstruation may develop.

In addition, Diphenhydramine may cause chills and increased sweating.

special instructions

During treatment with Diphenhydramine, you should avoid prolonged exposure to the sun and drinking alcohol.

When using the drug, you must avoid activities that require a high concentration of attention and speed of psychomotor reactions, as well as driving vehicles.

Analogs

Synonyms for Diphenhydramine are Grandim, Sticks with Diphenhydramine, Suppositories with Diphenhydramine, Diphenhydramine-Vial, Diphenhydramine-UBF, Diphenhydramine Bufus.

Analogues of the drug are Valocordin-Doxylamine, Bravegil, Tavegil, Donormil, Reslip, Clemastin, Clemastin-Eskom.

Terms and conditions of storage

According to the instructions, Diphenhydramine must be stored in a dark place, out of reach of children, at a temperature not exceeding 30 °C.

The shelf life of the drug is 5 years.

Name

Diphenhydramine ampoules

Release form

injection solution 10 mg/ml

INN

Diphenhydramine / Diphenhydramine.

ATX code: R06AA02.
Composition

1 ml of solution contains

Active substances

10 mg diphenhydramine (diphenhydramine).
Pharmacotherapeutic group

H1-antihistamines. Sedatives and hypnotics.
pharmachologic effect
Pharmacodynamics

It has antihistamine, antiallergic, antiemetic, hypnotic, and local anesthetic effects. Blocks histamine H1 receptors and eliminates the effects of histamine mediated through this type of receptor. Reduces or prevents histamine-induced smooth muscle spasms, increased capillary permeability, tissue swelling, itching and hyperemia. Antagonism with histamine manifests itself to a greater extent in relation to local vascular reactions during inflammation and allergies compared to systemic ones, i.e. decrease in blood pressure. Causes local anesthesia (when taken orally, a short-term sensation of numbness of the oral mucosa occurs), has an antispasmodic effect, blocks cholinergic receptors of the autonomic ganglia (lowers blood pressure). Blocks H3 - histamine receptors in the brain and inhibits central cholinergic structures. It has a sedative, hypnotic and antiemetic effect. It is more effective for bronchospasm caused by histamine liberators (tubocurarine, morphine, sombrevin), and to a lesser extent for allergic bronchospasm. For bronchial asthma it is inactive and is used in combination with theophylline, ephedrine and other bronchodilators.
Pharmacokinetics

After intravenous or intramuscular administration, it is widely distributed in the body, passes through the blood-brain barrier and the placenta. Binds to plasma proteins by 98-99%. Metabolized in the liver. The half-life (T1/2) is 1-4 hours. It is excreted in milk and can cause sedation in infants. Within a day, it is completely eliminated from the body, mainly in the form of benzhydrol conjugated with glucuronic acid, and only in small quantities - unchanged.

Indications for use

The drug is prescribed for treatment

• hives,
• hay fever,
• vasculitis,
• vasomotor rhinitis,
• angioedema,
• itchy dermatoses,
• acute iridocyclitis,
• allergic conjunctivitis and other allergic complications from taking various medications, including antibiotics.
• The drug is also used in the treatment of radiation sickness, chorea, sea and air sickness, and vomiting.
• Diphenhydramine solution 1% for injection can be used to reduce the severity of adverse reactions during blood transfusions, blood replacement fluids and other drugs.
• The drug is used as a sedative and hypnotic alone and in combination with other hypnotics.

Directions for use and doses

The drug is used intramuscularly, intravenously. The drug is not administered subcutaneously due to its irritating effect. Intramuscularly administered at a dose of 10-50 mg (1-5 ml of 1% solution). 20-50 mg of diphenhydramine is administered intravenously in 75-100 ml of isotonic sodium chloride solution.

Maximum doses for adults when administered intramuscularly: single - 0.05 g (5 ml of 1% solution), daily - 0.15 g (15 ml of 1% solution).
special instructions

Use with caution in patients with hyperthyroidism, increased intraocular pressure, diseases of the cardiovascular system, and in old age. Should not be used during work by vehicle drivers and people whose profession involves increased concentration of attention. During the treatment period, you should avoid drinking alcoholic beverages.

Side effects

From the nervous system and sensory organs: general weakness, fatigue, sedation, decreased attention, dizziness, drowsiness, headache, impaired coordination of movements, anxiety, increased excitability (especially in children), irritability, nervousness, insomnia, euphoria, confusion, tremor, neuritis, convulsions, paresthesia ; visual impairment, diplopia, acute labyrinthitis, tinnitus. In patients with local brain damage or epilepsy, it activates (even in low doses) convulsive discharges on the EEG and can provoke an epileptic attack.

From the cardiovascular system and blood: hypotension, palpitations, tachycardia, extrasystole, agranulocytosis, thrombocytopenia, hemolytic anemia.

From the gastrointestinal tract: dry mouth, short-term numbness of the oral mucosa, anorexia, nausea, epigastric distress, vomiting, diarrhea, constipation.

From the genitourinary system: frequent and/or difficulty urinating, urinary retention, early menstruation.

From the respiratory system: dry nose and throat, nasal congestion, thickening of bronchial secretions, tightness in the chest and difficulty breathing.

Allergic reactions: rash, urticaria, anaphylactic shock.

Others: sweating, chills, photosensitivity.

Contraindications

• Hypersensitivity,
• lactation,
• childhood (newborn period and state of prematurity),
• angle-closure glaucoma,
• prostate hypertrophy,
• stenosing ulcer of the stomach and duodenum,
• pyloroduodenal obstruction,
• bladder neck stenosis,
• pregnancy,
• bronchial asthma.

Interaction with other drugs

Sleeping pills, sedatives, tranquilizers and alcohol enhance (mutually) the depression of the central nervous system. MAO inhibitors enhance and prolong anticholinergic effects.
Overdose

Symptoms:

dry mouth, difficulty breathing, persistent mydriasis, facial flushing, depression or agitation (more often in children) central nervous system, confusion; in children - the development of seizures and death.

Treatment:

symptomatic and supportive therapy against the background of careful monitoring of breathing and blood pressure levels.
Release form

Solution for injection 10 mg/ml in ampoules of 1 ml in packages No. 10.

Contraindications

RUE "Belmedpreparaty"

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Diphenhydramine

A UNIQUE METHOD FOR TREATING INSOMNIA BY INHALATION OF THERAPEUTIC DOSES OF XENON! More details

Diphenhydramine is an antihistamine - 1st generation H1-histamine receptor blocker. Its history dates back to 1945. It has antihistamine, local analgesic, hypnotic, antiemetic, antiparkinsonian effects. By reducing capillary permeability, it prevents the development of tissue edema and hyperemia.

Medicines with antihistamine properties are found in almost every home. And Diphenhydramine is no exception. At the same time, most people use these drugs completely for other purposes, without really assessing the harm that they can cause to their body. The main purpose of using antihistamines is to prevent and/or eliminate allergy symptoms. The effects of taking Diphenhydramine can vary significantly, it all depends on the characteristics of a particular organism and dosage. Therefore, the main indications for prescribing Diphenhydramine are: Urticaria, allergies associated with seasonal flowering, allergic conjunctivitis, rhinitis, itchy dermatoses, allergic complications during drug therapy, blood transfusions and blood-substituting fluids; complex therapy of anaphylactic shock, radiation sickness, bronchial asthma; Parkinson's disease, Meniere's syndrome.

But many of our compatriots use Diphenhydramine as a sleeping pill. Sedative and hypnotic effects are primarily a side effect of the drug. The sedative effect of antihistamines requires extreme caution, especially in cases where a person’s profession requires increased concentration and rapid mental and physical reactions. It is impossible to fully engage in daily activities while taking Diphenhydramine.

Thus, the presence of a hypnotic effect in a particular drug does not make it a hypnotic.

Nowadays, when 3rd generation sleeping pills are available for the treatment of insomnia, so-called “pure” hypnotics (for example, Sanval). The use of Diphenhydramine as a sleeping pill has long lost its relevance.

The advantages of these drugs are less toxicity, lack of dependence effect, even higher selectivity of pharmacological action, causing a minimum of side effects in the form of daytime drowsiness, decreased concentration, and impaired coordination of movements.

diphenhydramine as a sleeping pill

In chapter Diseases, Medicines to the question: What is better as a sleeping pill, Diphenhydramine or Phenazepam?! given by the author Cutie Kimberly the best answer is diphenhydramine

walk before bed. I categorically do not recommend phenazepam, and there are a lot of fools all around.

Diphenhydramine is heavier. You have to sleep with him for a long time, otherwise it will be bad in the morning. Better than phenazepam. But not every day you get used to it.

For depression and insomnia, phenazepam is better. But it is strictly according to the recipe. . What do you have? after a binge?

Diphenhydramine. Keep in mind that you may end up on sleeping pills, so it’s better to do without them somehow. Drink valerian or motherwort better.

Diphenhydramine is not a sleeping pill at all and it sucks in the morning. If it’s not a problem, phenazepam is better, and even better, no sleeping pills ever. Try a couple of glycine tablets under your tongue before bed.

If you care about your health, then don’t use either one or the other. And try to fight depression. I used to often suffer from insomnia and depression and was able to overcome it. Maybe you can do it too.

In general, diphenhydramine is not a sleeping pill at all, but an anti-allergy drug, drowsiness is its side effect (if used as a sleeping pill, then with Suprastin this side effect is more pronounced), and phenozepam, if not abused, is a good drug.

The best sleeping pill is to stop the flow of your thoughts about pressing problems, relax the muscles of the arms and legs, the neck of the fingers and all the way to SLEEP

It works every time I do it myself

Similar question: is it better to cut off an arm or a leg? Neither diphenhydramine nor phenazepam. Fight depression: new hobbies, meeting new people, help someone who is worse off than you, take up sports or physical labor - you will sleep like a log. Normalize your wakefulness and sleep time: you need to wake up around 6-00, fall asleep at 22-00

If you are a night owl, choose your time, sometimes it’s worth taking an extra 15 minutes from your normal time of falling asleep - and that’s it, you won’t fall asleep for 2-3 hours

Diphenhydramine is an antihistamine whose side effect is terrible drowsiness, which we have learned to successfully use in medicine! ! And a hairdryer is a strong “sedative.” BUT, I don’t advise you to drink it yourself at all! ! firstly, you need to understand yourself, and drug therapy is used as a last resort, you don’t consider yourself crazy or hysterical, so let’s not look for easy ways and try to get out of this state on our own!!

Try better liquid Novopassit or glycine

phenazepam just don’t get too carried away with them, and if the depression is severe, then consult a doctor; depression can become stronger over time and if not treated in time, it can even become chronic

From what I tried, it was Donormil.

good pills. sold without a prescription in a pharmacy

Phenazepam is an ancient and dangerous tranquilizer. Diphenhydramine is an antihistamine. Let the doctor who diagnosed depression and insomnia prescribe treatment. Now there are more effective and safe drugs.

Diphenhydramine is not a sleeping pill, much less an antidepressant. . It's time for you to see a psychiatrist or change your environment

The effect and harm of Diphenhydramine on the body - symptoms of overdose

The antihistamine and sedative drug “Diphenhydramine”, due to its availability, often causes intoxication of the body. In addition, the drug can have a psychotropic effect when combined with alcoholic beverages. Diphenhydramine poisoning is a dangerous condition that can lead to irreversible consequences, drug-induced coma, or even death.

Indications for use of Diphenhydramine

“Diphenhydramine” is available in several dosage forms (in tablets, as a solution for injection in ampoules). One pack contains ten tablets, one ampoule contains 50 ml. The drug is most effective when administered intramuscularly or intravenously. The main active ingredient of the drug is diphenhydramine.

The drug has a wide spectrum of action, which makes it possible to prescribe “Diphenhydramine” for many different conditions. The benefits of the substance allowed it to be included in the list of vital medicines. The medicine belongs to the group of antihistamines. Indications for use are:

• various allergic reactions and complications that arose during drug therapy;
• radiation sickness therapy (as part of complex treatment);
• preventing or reducing side effects from blood or blood substitute fluid transfusions;
• insomnia and some stressful situations (as a sleeping pill);
• extensive traumatic lesions of the skin and soft tissues;
• stomach and duodenal ulcers, gastritis and bronchial asthma;
• sea ​​or air sickness, vomiting, Parkinson's disease.

Effect of the drug on the body

The mechanisms of development of allergic manifestations of various kinds are similar: in conditions of the immune system response, the concentration of histamine sharply increases, which stimulates a number of other biological processes.

Antihistamines can relieve most symptoms of allergic conditions. Such drugs are characterized by a number of common properties, namely:

• rapid action, which necessitates repeated doses of medications;
• persistent sedative and hypnotic effects;
• enhancing the effect of other medications when taken simultaneously;
• effective elimination of cough of an allergic nature, attacks of vomiting, nausea;
• increasing the viscosity of secretory biological fluids of the human body.

Thus, the normalization of sleep (and it is for this purpose that, as a rule, some people use Diphenhydramine) is achieved not by the direct effect of the drug, but is in some sense a side effect.

If used uncontrolled and excessively, the drug can cause harm.

Contraindications for taking Diphenhydramine

The drug is contraindicated for use as part of complex therapy for patients with the following diagnoses:

• angle-closure glaucoma - a periodic increase in intraocular pressure due to the cessation of the normal outflow of intraocular fluid;
• benign change and proliferation of prostate tissue;
• an ulcer that causes narrowing of some parts of the intestine;
• deterioration of the patency of the urinary canal;
• disturbance of the uniformity and frequency of the heart rhythm;
• violation of pigment metabolism (is a hereditary disease).

In addition, Diphenhydramine is not used for children under 2 years of age or with increased individual sensitivity to the main active ingredient. The drug should be used with caution in case of bronchial asthma, during pregnancy and lactation.

Compatibility with alcohol and other drugs

“Diphenhydramine” enhances the effect of some medications, so it is incompatible with other sedatives or psychostimulants. The medicine reduces the effectiveness of antiemetics.

During the period of therapy, you should avoid activities that require increased attention (first of all, you should stop driving), avoid drinking alcohol and, if possible, ultraviolet radiation.

Side effects of Diphenhydramine

The use of Diphenhydramine may provoke undesirable reactions from the following systems of the human body:

• central nervous system: depressant effect, excitability, drowsiness, confusion, tremors of extremities, convulsions, ringing in the ears, dizziness, irritability;
• cardiovascular and circulatory systems: various heart rhythm disturbances, decreased number of platelets or leukocytes;
• gastrointestinal tract: digestive disorders, dry mouth, prolonged nausea with bouts of vomiting;
• respiratory system: difficulty breathing, dry mucous membranes;
• other side effects: increased sweating, chills, allergy to Diphenhydramine, sensitivity to ultraviolet radiation.

Diphenhydramine poisoning: causes and dosage

In case of excessive dosage or uncontrolled use of the drug, intoxication is possible - the effect of the drug on the human body in this case becomes extremely negative.

The main causes of overdose are the use of large quantities of the drug by children, addiction to the drug during long-term therapy, the need for long-term treatment (for fractures, multiple injuries or nervous disorders), as well as the desire to increase the effects of alcohol or drugs.

The lethal dose of Diphenhydramine is ambiguous and depends on the person’s health status, body weight, indications, combination with other medications, narcotic substances or alcoholic beverages. Taking 40 mg of the drug is already considered a dangerous dosage, and for patients who take Diphenhydramine for a long time, the lethal dose increases to 100 mg.

What happens if you take a double dose of the drug during therapy? Even a slight overdose of Diphenhydramine can cause extremely dangerous consequences, including coma and death.

Main symptoms of overdose

Diphenhydramine poisoning in some cases is similar to a short-term mental disorder. Victims experience confusion, emotional overexcitability, disturbed orientation in time and space, incoherent speech, while the instinct of self-preservation (sense of danger) and awareness of one’s own personality are preserved.

An overdose can lead to disruption of the cardiovascular system, injuries received in a state of temporary mental disorder, and paralysis of the limbs.

The damage affects most body systems. Coma may occur, and when combined with drugs or alcohol, suicide or death due to cardiac dysfunction is possible.

In adults, characteristic signs of Diphenhydramine poisoning are the following conditions:

• thirst and dry mucous membranes;
• difficulty breathing, spasms;
• redness of the skin in the neck and face;
• delirium, hallucinations, confusion;
• sudden changes in blood pressure levels;
• throbbing headache, tremors of limbs.

Children often experience cramps of the limbs and body, which is an extremely negative sign that portends death.

Treatment of poisoning with Diphenhydramine

First aid for Diphenhydramine poisoning includes artificial stimulation of vomiting. It is imperative to immediately call an ambulance, since it is not possible to stop the consequences of an overdose at home. In a hospital setting, treatment involves purifying the blood and removing toxins with medications, and during medical procedures, the victim is given vitamins to prevent brain swelling. In case of coma accompanied by attacks of asphyxia, an artificial lung ventilation device is installed.

“Diphenhydramine” as a narcotic substance

“Diphenhydramine” is not a narcotic drug and is available for free sale without a prescription, but in some cases it is used as a drug. Among drug addicts, the use of “Diphenhydramine” in combination with alcohol is common; a group of people, when using the drug together, experience emotions that depend on the environment, so conflicts, depression, and attacks of aggression are possible.

Why then not simply ban Diphenhydramine at the state level or at least limit the sale of the drug? The latter is precisely what has been used recently by a number of states and individual regions. Diphenhydramine cannot be completely banned, since the drug is included in the list of vital and essential drugs.

Diphenhydramine is produced in ampoules in the form of a solution for intramuscular and intravenous administration.

The active substance of the drug is diphenhydramine. 1 ml contains 10 mg of active substance. In ampoules of 1 ml.

The effect of the drug on the central nervous system is due to the blockade of H1 receptors in the brain and the inhibitory effect on cholinergic structures. The use of Diphenhydramine relieves spasms of smooth muscles, weakens allergic reactions, reduces capillary permeability, and has a sedative, local anesthetic, hypnotic, and antiemetic effect.

After an injection of Diphenhydramine, its effect develops within a few minutes and lasts up to 12 hours.

According to the instructions, Diphenhydramine injections are indicated in the following cases:

• serum sickness;
• Quincke's edema;
• acute allergic conditions (as part of complex treatment and only in cases where the use of the tablet form is not possible);
• anaphylactoid and anaphylactic reactions (in combination with other drugs).

When pain of any etiology occurs, Analgin with Diphenhydramine produces a good analgesic effect.

Do not use Diphenhydramine if you are hypersensitive to diphenhydramine. Diphenhydramine injections are prohibited for prostatic hyperplasia, angle-closure glaucoma, epilepsy, duodenal and gastric ulcers, especially complicated by stenosis, as well as stenosis of the bladder neck.

Diphenhydramine is contraindicated in children under 7 months of age.

Diphenhydramine is not used as a local anesthetic due to the risk of local necrosis.

Diphenhydramine is prescribed with caution for bronchial asthma.

While using the drug, you should not drink alcoholic beverages, and you should not drive a car or drive potentially dangerous machinery.

According to the instructions, Diphenhydramine in ampoules is intended for intravenous or intramuscular administration.

Diphenhydramine for children over 14 years of age and adults is prescribed in a dosage of 1-5 ml three times a day. The maximum daily dose is 20 ml.

Diphenhydramine for children aged 7-12 months is prescribed in a dosage of 0.3-0.5 ml per day, at the age of 1-3 years - 0.5-1 ml of the drug per day, 4-6 years - 1-1.5 ml , 7-14 years – 1.5-3 ml per day. The drug may be administered every 8 hours if necessary.

An overdose of Diphenhydramine can cause stimulation or depression (especially in children) of the functions of the central nervous system. Dry mouth, dilated pupils, and gastrointestinal upset may also occur.

In case of overdose, it is necessary to perform gastric lavage and symptomatic treatment.

When treating an overdose, it is prohibited to use analeptics and adrenaline.

Diphenhydramine in ampoules enhances the effect of ethanol and all drugs that depress the central nervous system.

When Diphenhydramine is used together with psychostimulants, an antagonistic interaction is observed.

When treating poisoning, Diphenhydramine can reduce the emetic effect of apomorphine.

The anticholinergic activity of diphenhydramine is enhanced by monoamine oxidase inhibitors.

To enhance the effect of the drug, injections of Analgin with Diphenhydramine are often used. So, to quickly relieve fever, this combination effectively helps: one ampoule of Analgin with Diphenhydramine and Papaverine.

Diphenhydramine injections during pregnancy and breastfeeding should be prescribed with great caution and only in the absence of an adequate alternative.

On the part of the nervous system, side effects such as drowsiness, impaired coordination of movements, euphoria, insomnia, decreased speed of psychomotor reactions, agitation, irritability, and tremor are possible.

From the cardiovascular system, tachycardia, decreased blood pressure and extrasystole often occur.

Allergic reactions when taking Diphenhydramine: itching and skin rash, urticaria, photosensitivity.

Side effects from the hematopoietic organs: thrombocytopenia, hemolytic anemia, agranulocytosis.

From the urinary system, urination disorders may occur.

Diphenhydramine is classified as a List B drug with a recommended shelf life of no longer than 5 years.

In this article you can read the instructions for use of the drug Diphenhydramine. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Diphenhydramine in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Diphenhydramine in the presence of existing structural analogues. Use for the treatment of allergic attacks and conditions in adults, children, as well as during pregnancy and lactation.

Diphenhydramine- first generation H1-histamine receptor blocker. The effect on the central nervous system is due to the blockade of H3-histamine receptors in the brain and inhibition of central cholinergic structures. Relieves spasm of smooth muscles (direct effect), reduces capillary permeability, prevents and weakens allergic reactions, has local anesthetic, antiemetic, sedative effects, moderately blocks cholinergic receptors of the autonomic ganglia, and has a hypnotic effect. Antagonism with histamine manifests itself to a greater extent in relation to local vascular reactions during inflammation and allergies than to systemic ones, i.e. decrease in blood pressure. However, when administered parenterally to patients with a deficiency of circulating blood volume, a decrease in blood pressure and an increase in existing hypotension is possible due to the ganglion-blocking effect. In people with local brain damage and epilepsy, it activates (even in low doses) epileptic discharges on the electroencephalogram and can provoke an epileptic attack.

The action develops within a few minutes, duration - up to 12 hours.

Pharmacokinetics

Penetrates the blood-brain barrier. Metabolized mainly in the liver, partially in the lungs and kidneys. Within 24 hours, it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Significant amounts are excreted in milk and may cause sedation in infants (a paradoxical reaction characterized by excessive excitability may occur).

Indications

• anaphylactic and anaphylactoid reactions (in complex therapy);
• Quincke's edema;
• allergic reactions (urticaria, hay fever, angioedema);
• allergic conjunctivitis;
• vasomotor rhinitis;
• hemorrhagic vasculitis;
• serum sickness;
• itchy dermatoses;
• sleep disorders (monotherapy or in combination with sleeping pills);
• chorea;
• sea ​​and air sickness;
• vomiting of pregnant women;
• Meniere's syndrome;
• premedication.

Release forms

Tablets 50 mg.

Solution for intravenous and intramuscular administration (injections in ampoules) 10 mg/ml.

Instructions for use and dosage

Intravenously or intramuscularly.

For adults and children over 14 years of age, intravenously or intramuscularly, 1-5 ml (10-50 mg) of a 1% solution (10 mg/ml) 1-3 times a day; the maximum daily dose is 200 mg.

For children aged 7 months to 12 months, 0.3-0.5 ml (3-5 mg), from 1 year to 3 years, 0.5-1 ml (5-10 mg), from 4 to 6 years, 1-1.5 ml (10-15 mg), from 7 to 14 years, 1.5-3 ml (15-30 mg) if necessary every 6-8 hours.

Pills

Adults orally - 30-50 mg 1-3 times a day. The course of treatment is 10-15 days. As a sleeping pill - 50 mg before bedtime.

When taken orally, single doses for children under 1 year of age are 2-5 mg; from 2 to 5 years - 5-15 mg; from 6 to 12 years - 15-30 mg.

Side effect

• drowsiness;
• weakness;
• decreased speed of psychomotor reaction;
• impaired coordination of movements;
• dizziness;
• tremor;
• irritability;
• euphoria;
• excitement (especially in children);
• insomnia;
• dryness of the mucous membrane of the mouth, nose, bronchi (increased sputum viscosity);
• hemolytic anemia, thrombocytopenia, agranulocytosis;
• decrease in blood pressure;
• tachycardia;
• extrasystole;
• urinary disturbance;
• hives;
• skin rash;

Contraindications

• hypersensitivity to diphenhydramine;
• angle-closure glaucoma;
• prostatic hyperplasia;
• peptic ulcer of the stomach and duodenum, complicated by stenosis;
• bladder neck stenosis;
• epilepsy;
• children's age up to 7 months.

Use during pregnancy and breastfeeding

Take with caution during pregnancy and lactation.

special instructions

During the treatment period, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (driving a car, etc.).

During treatment with diphenhydramine (the active ingredient in Diphenhydramine), UV radiation and ethanol (alcohol) should be avoided.

Drug interactions

Enhances the effect of ethanol (alcohol) and drugs that depress the central nervous system.

Monoamine oxidase inhibitors (MAOIs) enhance the anticholinergic activity of diphenhydramine.

Antagonistic interactions are observed when co-administered with psychostimulants.

Reduces the effectiveness of apomorphine as an emetic drug in the treatment of poisoning.

Strengthens the anticholinergic effects of drugs with m-anticholinergic activity.

Analogues of the drug Diphenhydramine

Structural analogues of the active substance:

• Allergin;
• Diphenhydramine Bufus;
• Diphenhydramine-Vial;
• Diphenhydramine-UBF;
• Diphenhydramine solution for injection 1%;
• Psilo-balm.

Analogs in terms of therapeutic effect (antihistamines):

• Aviomarine;
• Alerza;
• Alerpriv;
• Allergodil;
• Allertek;
• Allerfex;
• Astemizole;
• Bonin;
• Bronal;
• Histaglobin;
• Histaphen;
• Hyphastus;
• Diazolin;
• Dinox;
• Zyrtec;
• Zodak;
• Kestin;
• Claritin;
• Clemastine;
• Loratadine;
• Lotharen;
• Mebhydrolin;
• Parlazin;
• Peritol;
• Pipolfen;
• Primalan;
• Suprastin;
• Tavegil;
• Telfast;
• Pheniramine maleate;
• Fenistil;
• Fenkarol;
• Chloropyramine;
• Cetirizine;
• Cetrin;
• Erespal;
• Erius;
• Erolyn.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps and look at the available analogues for the therapeutic effect.

Diphenhydramine in ampoules is a sedative, hypnotic and antihistamine drug, which is characterized by weak ganglion-blocking and local anesthetic properties.

The components included in the composition of diphenhydramine in ampoules are as follows:

• the main component is diphenhydramine hydrochloride;
• as an auxiliary - water for injection.

Diphenhydramine is prescribed by a doctor in the following cases:

1. allergic reactions (urticaria, hay fever);
2. allergic conjunctivitis;
3. acute iridocyclitis;
4. vasomotor rhinitis;
5. allergic dermatitis;
6. itchy dermatosis;
7. parkinsonism, chorea, insomnia;
8. sea ​​and air sickness, radiation sickness.

Instructions for the use of diphenhydramine in ampoules suggest the following contraindications to the use of the drug:

1. hypersensitivity;
2. at the time of lactation;
3. angle-closure glaucoma;
4. prostatic hypertrophy;
5. bladder neck stenosis;
6. bronchial asthma;
7. pregnancy.

Instructions for use of diphenhydramine involve intramuscular administration of the drug. Adults and children over 12 years of age can use diphenhydramine in an amount of 10-50 mg.

If at least one of the symptoms listed below occurs, you should immediately consult a specialist.

When using diphenhydramine, the patient may experience the following side effects:

1. digestive system: dry mouth, nausea, vomiting, constipation and diarrhea;
2. nervous system: headache, drowsiness, dizziness, weakness, nervousness, anxiety, irritability, insomnia, neuritis, convulsions;
3. sense organs: tinnitus, vision changes, acute labyrinthitis;
4. genitourinary system: difficulty and frequent urination, early menstruation, urinary retention.

In case of overdose, patients experience suppression of the central nervous system, accompanied by agitation or depression, dry mouth, and paresis of the gastrointestinal tract.

The instructions for use suggest that diphenhydramine is pharmaceutically incompatible with amphotericin B, cefmetazole sodium, cephalothin sodium, hydrocortisone succinate, barbiturates, and some radiocontrast agents.

The active substance is Diphenhydramine.

1 ml of solution contains 10 mg of this active substance in the form of diphenhydramine hydrochloride. An additional substance is injection water.

1 tablet contains 50 mg of active substance.

Tablets and solution of Diphenhydramine IV and IM for injection.

Diphenhydramine - what is it?

Diphenhydramine is H1-histamine receptor blocker. Has a sedative and hypnotic effect.

Pharmacological group: H1-antihistamines.

The main active ingredient is Diphenhydramine. The mechanism of action is based on the inhibitory effect of the drug on central, cholinergic structures, blocking H3-histamine receptors in the brain. Diphenhydramine relieves attacks of itching, tissue edema, hyperemia, prevents spasms of smooth muscle tissue, has a positive effect on capillary permeability. Taking oral forms causes a short-term feeling of numbness in the mouth. The drug has antiparkinsonian, hypnotic, sedative, and antiemetic effects. By blocking the cholinergic receptors of the ganglia, it reduces blood pressure and can increase existing hypotension. In people with epilepsy and local brain damage, even low doses of Diphenhydramine can provoke epileptic seizure, and the EEG shows activation of epileptic discharges. The drug is most effective when bronchospasm, provoked by taking histamine liberators (morphine, tubocurarine). The drug is least effective for bronchospasm of allergic origin. With repeated doses, the hypnotic and sedative effects are more pronounced. The drug begins to act an hour after entering the body, the effective effect lasts up to 12 hours.

Why and for what purpose are tablets and solution prescribed?

The drug is used to relieve allergic reactions, when itchy dermatosis, allergic dermatitis, rhinosinusitis, vasomotor rhinitis, acute iridocyclitis, allergic conjunctivitis. The drug is used for insomnia, chorea, Parkinson's disease, radiation sickness, air sickness, sea sickness, Meniere's syndrome, vomiting in pregnant women. The drug is prescribed as premedication, with extensive damage to soft tissues and skin of a traumatic nature, with serum sickness, hemorrhagic vasculitis.

Diphenhydramine is not prescribed for prostatic hyperplasia, angle-closure glaucoma, epilepsy, bladder stenosis, or stenosing peptic ulcer of the digestive system. For bronchial asthma, breastfeeding, pregnancy, prescribe with caution.

Taking the drug may cause tremors, dizziness, numbness in the mouth, dry mouth, increased drowsiness, photosensitivity, asthenia, headaches, nausea, paresis of accommodation, decreased speed of psychomotor reaction, impaired coordination of movements. The use of Diphenhydramine in children may be accompanied by a feeling euphoria, irritability, paradoxical insomnia.

Diphenhydramine tablets, instructions for use

30-50 mg one to three times a day, duration of therapy 10-15 days.

For insomnia, 50 mg is prescribed half an hour before bedtime.

At postencephalic, idiopathic parkinsonism initially prescribed 25 mg three times a day, subsequently the dosage is gradually increased to 50 mg 4 times a day.

For motion sickness, you need to take 25-50 mg tablets every 6 hours.

A solution of Diphenhydramine is administered intravenously 20-50 mg of the drug, having previously dissolved in 100 ml of 0.9 sodium chloride, intramuscular injections of 10-50 mg are administered once.

Rectal suppositories after a cleansing enema are administered twice a day.

In ophthalmology, 2 drops of solution (0.2-0.5%) are instilled into each conjunctival sac 3 times a day.

In allergology, 0.05 g of the drug is administered intranasally.

Taking high doses causes depression of the nervous system, paresis of the digestive organs, dry mouth, dilated pupils, and depression. No specific antidote has been developed; intravenous administration is required plasma replacement fluids, use of drugs that increase blood pressure. It is unacceptable to use analeptics, epinephrine.

In case of severe overdose, death, injury, heart attack, and paralysis are possible.

Diphenhydramine enhances the effect of drugs that depress the nervous system. When used together with psychostimulants an antagonistic effect is recorded. MAO inhibitors increase the anticholinergic activity of the drug. When treating poisonings and intoxications, the medicine reduces its effectiveness apomorphine.

With a prescription or without? A prescription is required to purchase.

In a dark place, out of reach of children, at a temperature of no more than 30 degrees Celsius.

No more than 4 years.

The medication has a negative effect on activities that require increased concentration, control of complex mechanisms, and driving vehicles. During therapy, it is necessary to avoid drinking alcoholic beverages and limit exposure to the sun and ultraviolet radiation to a minimum. The antiemetic effect of the drug may mislead the doctor in the differential diagnosis acute appendicitis, recognizing symptoms of overdose, intoxication.

International name (INN) of Diphenhydramine: Diphenhydramine.

The Pharmacopoeia contains a description under FS 42-0232-07.

Described on Wikipedia under the name Diphenhydramine.

It is often necessary to know the name of a drug in Latin. Here, for example, is the recipe in Latin:

Rp.: Dimedroli 0.05

D.t. d. N 10 in tab. S.

Sticks with Diphenhydramine in Latin: baculi cum dimedrolum.

Structural formula of the active substance:

In fact, the medication is not a drug, but in combination with alcoholic drinks and in large doses it causes hallucinations, as well as addiction if used frequently.

In general, it is possible, but the concentration of the active substance in ampoules is less than in tablets.

It is contraindicated to take the drug with alcohol. The effect of alcohol increases, the hypnotic effect increases, and severe damage to the body is possible. The outcome is impossible to predict, especially when using large doses. Vodka with diphenhydramine may be the last drink in the life of a person who has consumed this mixture; the lethal dose can be very small when combined with alcohol.

Contraindicated during pregnancy and breastfeeding.

Analogues are means Kalmaben, Dramamine.

The drug acts quickly and helps with fever, insomnia, pain, and allergies. The disadvantages are the side effects of the medication, as well as the fact that it is considered outdated.

The price of Diphenhydramine tablets is 3-6 rubles per pack of 10 pieces. How much do tablets cost in Ukraine? The package can be purchased for 6-8 hryvnia.

You can buy Diphenhydramine in ampoules at a price of 25-30 rubles for 10 pieces in Russia and for 15-18 UAH in Ukraine.

Diphenhydramine 50 mg No. 20 tablets Dalkhimfarm OJSC

Diphenhydramine-vial 1% 1ml No. 10 amp.

Diphenhydramine 50mg No. 10 tabletsBarnaul Medicinal Products Plant LLC

Diphenhydramine 1% 1ml No. 10 amp. Belmedpreparaty

Diphenhydramine 1% 1ml No. 10 ampoules Biosynthesis OJSC

Diphenhydramine Belmedpreparaty (Minsk), Belarus

DiphenhydramineDalkhimfarm (Khabarovsk), Russia

DiphenhydramineHealth to the people (Ukraine, Kharkov)

DiphenhydramineGalichfarm (Ukraine, Lvov)

Diphenhydramine Darnitsa (Ukraine, Kyiv)

Diphenhydramine solution d/in. 1% amp. 1ml No. 10 Darnitsa

Diphenhydramine solution d/in. 1% amp. 1ml No. 10 Darnitsa

Diphenhydramine 50 mg No. 10 tablet.

Diphenhydramine 1%/1 ml No. 10 solution d/in.amp.

Diphenhydramine 50 mg No. 10 tablet.

For acute pain symptoms with a high temperature, which is not brought down by other antipyretic compounds, you can give injections with a solution of analgin with diphenhydramine. The effectiveness of medicines in pairs is higher, and they are considered ideal. Adults and children can receive a double injection. But starting in 2010, pediatricians began to have a negative attitude towards these injections. Our specialists will tell you what purposes and contraindications an injection made from a double composition has: analgin and diphenhydramine.

Why are the drugs effective in combination?

Thanks to the combination of active ingredients, analgin + diphenhydramine is effective in several directions at once: analgesic, antipyretic, decongestant, anti-inflammatory and antiallergic effect.

The absorption of medications is high, and the effect on the patient’s body is long-lasting (up to 6 hours). The high efficiency of the injection makes it possible to use the composition in the most severe cases.

Components of the solution

Analgin is an analgesic based on pyrazoline. Relieves painful spasms of various origins. Pharmacology produces in the form of pills and solution. The injection is given intramuscularly or intravenously. Absorption in injections is faster and more effective.

Diphenhydramine is an antihistamine with a pronounced anti-inflammatory effect. You can purchase it in the form of pills and solution, only with a doctor's prescription.

Analgin and diphenhydramine are excreted in the urine within 24 hours.

In what cases can it be used and contraindications?

In combination, the solution is used to relieve symptoms:

• prolonged fever associated with viral or bacterial diseases;
• pathologies of varying severity with pain syndromes;
• burns, headaches, muscle pain.

The solution is contraindicated for patients with diseases:

• asthma and acute forms of allergic reaction;
• heart failure;
• kidney diseases;
• neurology of varying severity.

Side effects are associated with incorrect dosage of the medication and injections performed at home, without doctor’s recommendations.

Dosing by age

For pain and high fever, you can use analgin with diphenhydramine in combination in the form of pills or injections.

We do not recommend giving an injection to a small child without a doctor, as the baby may have an individual intolerance to the solution.

It is better to make the solution intramuscularly, since the gastrointestinal tract is not damaged and the components begin to act faster. There are norms for a ready-made composition: For an adult and a child from 10 years old, 1–2 ml/2 times every 24 hours; for a younger child, from 3 years old, 0.2 ml per 10 kg of weight. But in total no more than 1 ml.

Before the injection, carefully recalculate the patient’s weight and mg of solution, otherwise irreparable harm can be caused to the patient. It is better for the child to try to relieve the fever with suppositories or other drugs before injecting the solution.

They will tell you more about how to give an injection in the buttock in the video.