Phenazepam is a medicine against negative emotions. Phenazepam tablets: instructions, reviews and prices

"Phenazepam" is a tranquilizer belonging to the group of benzodiazepine derivatives. It has a pronounced hypnotic, muscle relaxant, anticonvulsant and anxiolytic effect. The effect of anticonvulsant, narcotic, hypnotic drugs, ethyl alcohol under the influence of the drug "Phenazepam" is significantly enhanced. The instruction describes the pharmacokinetics of the drug: there is a good absorption of the drug from the gastrointestinal tract when taken orally. Moreover, the maximum level of reaching the concentration of Phenazepam in the blood occurs after 1-2 hours, its half-life is 6-10 hours, which is carried out mainly through the kidneys.

Indications for the use of the drug "Phenazepam"

The instruction to the medicinal product lists the diseases in which the use of this medicine is indicated:

• treatment of epilepsy, tics, various hyperkinesis, athetosis, muscle rigidity;
• removal of substance abuse and alcohol withdrawal, seizures of various origins;
• various psychopathic and psychopathic, neurosis-like, neurotic states, accompanied by frequent mood swings and increased irritability), fear, anxiety.

Contraindications to taking the drug "Phenazepam"

The instructions for the drug warns that this medicine is contraindicated in people with severe myasthenia gravis, as well as with impaired functional activity of the kidneys and (or) liver, severe depression, coma, angle-closure glaucoma, shock, respiratory failure. In addition, it is forbidden to take the remedy for intoxication with alcohol, narcotic drugs, hypnotics, antipsychotics, other tranquilizers, during pregnancy, at a minor age, in the presence of hypersensitivity to the components of the drug.

The drug "Phenazepam". Compound

Each white tablet contains:

• phenazepam (0.0025, 0.001, 0.0005 g);
• gelatin;
• talc;
• milk sugar;
• calcium stearate;
• starch.

Each package contains tablets in a blister of 100 or 50 pieces.

How to take the drug "Phenazepam"? Instruction

With extreme caution, the drug is prescribed to people engaged in potentially hazardous activities that require quick response and increased attention, as well as the elderly.

Start taking the drug with minimal doses (from 0.5 to 1 mg) two to three times a day. Further, the dosage is increased to 2-5 mg. A subsequent increase in the dose of the drug, reaching up to 10 mg, is possible only under the supervision of the attending doctor in a hospital.

The medicine "Phenazepam". Side effects

As a result of therapeutic treatment with this drug, side reactions such as dizziness, nausea, muscle weakness, drowsiness can sometimes occur. In very rare cases, mydriasis and ataxia may occur. Even if one of the above symptoms occurs, it is necessary to urgently stop therapy with the drug and immediately consult a doctor.

With an overdose of the drug "Phenazepam", symptoms such as shortness of breath and shortness of breath, a decrease in blood pressure, a decrease in reflex ability, bradycardia, confusion, increased drowsiness, and coma may appear. That is why in this case it is necessary to call an ambulance team, symptomatic treatment and gastric lavage are indicated.

Recommendations for prescribing the drug "Phenazepam" can only be made by a qualified specialist, it is imperative to consult with a psychotherapist who has the right to decide whether taking this medication is necessary in a particular case.

Phenazepam is a tranquilizer that has a pronounced anti-anxiety, anticonvulsant, muscle relaxant effect, calms the central nervous system. It is used for various neurotic and psychopathic conditions, to suppress feelings of fear, anxiety, and can be prescribed for withdrawal symptoms.

The drug can be highly addictive, and after prolonged continuous use, a person develops a strong dependence, which results in serious disorders of the nervous system. If at the initial stages of using the drug in a person, drowsiness and positively colored emotions are noted, then with the continuous use of Phenazepam, positive emotions are replaced by negative ones.

Self-medication with Phenazepam, exceeding the dosages prescribed by the doctor, increasing the duration of the treatment course leads to unpredictable, severe and irreversible consequences.

Clinical and pharmacological group

Tranquilizer.

Terms of sale from pharmacies

for sale by prescription.

Price

How much does Phenazepam cost in pharmacies? The average price is at the level of 110 rubles.

Can you buy without a prescription?

Phenazepam is a so-called minor tranquilizer, a drug that inhibits many processes at the level of the central nervous system. It has a wide spectrum of action, but can also cause numerous side effects. In general, we can say that the reaction to certain doses of the drug in all people is to some extent individual. Since the drug is potentially life-threatening in case of an overdose, its sale is carried out strictly according to medical prescriptions. In this way, the state provides partly the security of the population.

Benzodiazepines (including phenazepam) are sold strictly by prescription for the following reasons:

• the drug has many contraindications, and the patient himself cannot always recognize them;
• if taken incorrectly, the drug can cause an overdose;
• an overdose of the drug is dangerous by stopping breathing and heartbeat;
• phenazepam is sometimes used by addicted patients to ease the “withdrawal”;
• Phenazepam may be habit-forming with long-term use.

Thus, officially in most countries, phenazepam cannot be purchased without a doctor's prescription. It is also prohibited to transport it across the state border without an appropriate certificate. Theoretically, it is possible to purchase the drug from private individuals, but its use in this case will be fraught with very serious risks.

Composition and form of release

Phenazepam is available in the following forms:

• tablets of 0.5 mg, 1 mg or 2.5 mg: flat-cylindrical, white, equipped with a facet (0.5 and 2.5 mg) or a risk and a facet (1 mg). The drug is packaged in blisters (10 or 25 tablets each) or polymer jars (50 tablets each) and cardboard packs (2 or 5 blisters or 1 jar per pack);
• solution for intramuscular and intravenous administration: slightly colored or colorless. The drug is packaged in glass ampoules of 1 ml and blisters (5 ampoules each). Ampoules are packed in cardboard boxes (10 ampoules each) or cardboard packs (2 blisters each).

The composition of 1 tablet includes:

• active ingredient: phenazepam - 0.5, 1 or 2.5 mg;
• excipients: talc, calcium stearate, povidone, lactose, potato starch.

The composition of 1 ml of solution includes:

• active ingredient: phenazepam - 1 mg;
• excipients: sodium hydroxide solution 0.1 M, low molecular weight medical polyvinylpyrrolidone, tween-80, sodium pyrosulfite, distilled glycerol, water for injections.

Pharmacological effect

The main active ingredient is phenazepam. It is a benzodiazepine derivative that exhibits tranquilizing, hypnotic, and anticonvulsant effects. It has a fairly high activity, and in terms of the strength of the tranquilizing and anxiolytic action it surpasses other drugs in this group. Effects of taking phenazepam:

1. Anticonvulsant.
2. Muscle-relaxing.
3. Hypnotic.
4. Anti-anxiety (tranquilizing).
5. Sedative.

The main effect is tranquilizing, which means eliminating the patient's feelings of anxiety, fear and anxiety. Phenazepam helps to reduce emotional tension. After a course of treatment, obsessive thoughts, increased suspiciousness, and a negative attitude towards what is happening disappear in patients. Phenazepam does not have a positive effect on the symptoms caused by psychotic pathologies (hallucinations, delusions).

The sedative effect is expressed mainly in a decrease in psychomotor excitability, and the hypnotic effect is expressed in facilitating sleep, increasing its duration and improving its quality. The mechanism of action of Phenazepam is to influence certain receptors that are located in the brain and spinal cord, so all effects are of central origin.

Indications for use

What helps? Phenazepam is effective in the following cases:

• with reactive psychoses;
• when stopping alcohol withdrawal;
• for the treatment of hypochondriacal-senestopathic syndrome;
• to eliminate autonomic dysfunctions and sleep disorders;
• for the prevention of states of emotional stress, anxiety and fear;
• for the treatment of autonomic lability, muscle rigidity, tics and hyperkinesis;
• as an anticonvulsant for the treatment of patients with myoclonic and temporal lobe epilepsy;
• with neurotic, psychopathic and other conditions accompanied by increased irritability, anxiety, tension, fear and emotional lability.

How long does it take for phenazepam to work?

The duration of action of phenazepam is on average 3-6 hours, but some of its effects may last a little longer. The time of onset of action depends on the route of administration of the drug. With oral ( in tablets) reception is about 15 - 20 minutes, with intramuscular injection - faster, and with intravenous - even faster.

Contraindications

The drug should not be taken under the following conditions:

• poisoning with sleeping pills with a weakening of vital functions;
• depression with the manifestation of suicidal tendencies;
• respiratory dysfunction;
• the presence of hypersensitivity to the components of the drug;
• coma and shock conditions;
• angle-closure glaucoma - a predisposition either during an acute course;
• acute drug and alcohol poisoning;
• pregnancy, breastfeeding.

Due to the fact that the efficacy and safety of therapy with the use of Phenazepam for children and adolescents under 18 years of age has not been determined, the drug is not used for treatment.

Use strictly under the supervision of a physician, adjusting the dosage in such conditions:

• apnea;
• spinal or cerebral ataxia;
• drug addiction;
• organic disorders of the brain;
• psychosis;
• kidney or liver failure.

Elderly patients should be used with caution.

Appointment during pregnancy and lactation

Phenazepam can be prescribed to pregnant women only for health reasons. The active substance has a negative effect on the fetus, increases the likelihood of congenital malformations, and inhibits the development of the central nervous system of the unborn child. It is children who are most sensitive to the ability of benzodiazepines to suppress the functions of the central nervous system.

With long-term treatment of a pregnant woman with Phenazepam, a withdrawal syndrome may be observed in a newborn. It is also dangerous to use immediately before childbirth, since the drug can provoke respiratory depression, decreased muscle tone, hypothermia and weakening of sucking movements.

Dosage and method of application

As indicated in the instructions for use, Phenazepam tablets are taken orally, without chewing, with a sufficient amount of water. The dose of the drug is determined by the doctor depending on the indications and characteristics of the patient's body.

Inside with sleep disorders - 250-500 mcg 20-30 minutes before bedtime. For the treatment of neurotic, psychopathic, neurosis-like and psychopathic conditions, the initial dose is 0.5-1 mg 2-3 times a day. After 2-4 days, taking into account the effectiveness and tolerability, the dose can be increased to 4-6 mg / day. With severe agitation, fear, anxiety, treatment begins with a dose of 3 mg / day, quickly increasing the dose until a therapeutic effect is obtained. In the treatment of epilepsy - 2-10 mg / day.

For the treatment of alcohol withdrawal - inside, 2-5 mg / day or / m, 500 mcg 1-2 times / day, with vegetative paroxysms - / m, 0.5-1 mg. The average daily dose is 1.5-5 mg, it is divided into 2-3 doses, usually 0.5-1 mg in the morning and afternoon and up to 2.5 mg at night. In neurological practice, in diseases with muscle hypertonicity, 2-3 mg are prescribed 1-2 times / day. The maximum daily dose is 10 mg.

To avoid the development of drug dependence with course treatment, the duration of the use of phenazepam is 2 weeks (in some cases, the duration of treatment can be increased to 2 months). With the abolition of phenazepam, the dose is reduced gradually.

withdrawal syndrome

Phenazepam is one of the drugs that can cause addiction. In patients who have developed dependence on phenazepam, characteristic symptoms may appear after its withdrawal. Usually they are combined into two concepts - the "rebound" syndrome and the withdrawal syndrome. Each of them has its own development mechanism. It should be noted that with the correct use of phenazepam, the vast majority of patients do not develop any of these syndromes.

The “rebound” syndrome is understood as an exacerbation of the symptoms of the underlying pathology, for which the patient was treated with phenazepam. Thus, the manifestations of this syndrome will be to a certain extent opposite to the action of the drug. The patient may experience insomnia, irritability, tremors (trembling in the limbs), emotional arousal. All this is the result of excitation of the nervous system, which for a long time was suppressed by taking phenazepam.

Withdrawal is somewhat similar to rebound, and many of the symptoms are the same. However, in the case of withdrawal syndrome, the symptoms may be more varied. This condition is somewhat similar to the "withdrawal" of drug addicts, although such severe conditions in the event of the abolition of phenazepam practically do not occur.

The withdrawal syndrome may include the following symptoms and manifestations:

• suicidal tendencies;
• severe depression;
• increased heartbeat;
• nervous excitement;
• severe headaches;
• convulsions;
• unstable blood pressure;
• stool disorders.

All these symptoms can occur with abrupt withdrawal of the drug, especially if it was taken in large doses or for a long time. The duration of the rebound syndrome itself or the withdrawal syndrome can be different. Symptoms usually resolve within a week or so. However, cases are described when some manifestations persisted for more than a month.

In order to prevent such a deterioration in the condition, phenazepam is canceled gradually, slightly reducing the dose every day. Of course, with a single dose (for example, once a month to combat insomnia), such a long-term withdrawal is not required, since addiction does not have time to develop.

Adverse reactions

While taking Feazepam tablets in patients with increased individual sensitivity, some side effects may develop:

1. Allergic reactions - skin itching, rash, urticaria;
2. On the part of the hematopoietic system - a decrease in the level of leukocytes, neurophiles, hemoglobin, platelets;
3. On the part of the reproductive system - a decrease in sexual desire;
4. From the side of the nervous system - a constant feeling of fatigue, drowsiness, lethargy, dizziness, decreased concentration, ataxia, depression of consciousness, disorientation in space, confusion, headaches, tremor of the limbs, memory impairment, impaired coordination of movements, myasthenia gravis, attacks of aggression, suicidal thoughts, unreasonable fear and anxiety;
5. On the part of the digestive system - dry mouth, stomach pain, heartburn, nausea, vomiting, lack of appetite, liver disease, inflammation of the pancreas, increased activity of liver transaminases;
6. From the side of the cardiovascular system - tachycardia, shortness of breath, a decrease or rapid increase in blood pressure, panic attacks.

If one or more side effects occur, the patient should consult a doctor for advice, it may be necessary to cancel the drug treatment or reduce the dose.

Overdose

In case of an overdose, confusion, decreased reflexes, drowsiness and even coma may appear. Patients may complain of shortness of breath, tremor, bradycardia. The inhibitory effect on the central nervous system can lead to a suicide attempt in the patient. At the first signs, gastric lavage, sorbent intake, symptomatic therapy, especially aimed at maintaining respiratory function, are indicated.

special instructions

In the process of treatment, patients are strictly prohibited from using ethanol.

The efficacy and safety of the drug in patients under 18 years of age has not been established.

In patients who have not previously taken psychoactive drugs, there is a therapeutic response to the use of phenazepam at lower doses, compared with patients taking antidepressants, anxiolytics or suffering from alcoholism.

With renal and / or liver failure and long-term treatment, it is necessary to monitor the picture of peripheral blood and the activity of liver enzymes.

Like other benzodiazepines, it has the ability to cause drug dependence with long-term use in high doses (more than 4 mg / day). With a sudden cessation of administration, a withdrawal syndrome may occur (including depression, irritability, insomnia, increased sweating), especially with prolonged use (more than 8-12 weeks). If unusual reactions occur in patients such as increased aggressiveness, acute states of arousal, fear, suicidal thoughts, hallucinations, increased muscle cramps, difficulty falling asleep, superficial sleep, treatment should be discontinued.

Use with caution in hepatic and / or renal insufficiency, cerebral and spinal ataxia, a history of drug dependence, a tendency to abuse psychoactive drugs, hyperkinesis, organic brain diseases, psychosis (paradoxical reactions are possible), hypoproteinemia, sleep apnea (established or suspected ) in elderly patients.

In case of overdose, severe drowsiness, prolonged confusion, decreased reflexes, prolonged dysarthria, nystagmus, tremor, bradycardia, shortness of breath or shortness of breath, decreased blood pressure, coma are possible. Gastric lavage, activated charcoal are recommended; symptomatic therapy (maintenance of breathing and blood pressure), the introduction of flumazenil (in a hospital setting); hemodialysis is ineffective.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Increases the concentration of imipramine in the blood serum.
2. Phenazepam may increase the toxicity of zidovudine.
3. With the simultaneous use of phenazepam reduces the effectiveness of levodopa in patients with parkinsonism.
4. Inhibitors of microsomal oxidation increase the risk of developing toxic effects. Inducers of microsomal liver enzymes reduce the effectiveness.
5. There is a mutual enhancement of the effect with the simultaneous use of antipsychotic, antiepileptic or hypnotic drugs, as well as central muscle relaxants, narcotic analgesics, ethanol.
6. With simultaneous use with antihypertensive agents, it is possible to increase the antihypertensive effect. Against the background of the simultaneous appointment of clozapine, it is possible to increase respiratory depression.

Catad_pgroup Anxiolytics (tranquilizers)

Phenazepam tablets - official instructions for use

Registration number:

Tradename:

International non-proprietary name or grouping name:

Dosage form:

Compound:

Description:

Pharmacotherapeutic group:

ATX code:

Pharmacological properties

Indications for use:

Contraindications:

Use during pregnancy and lactation

Method of application and dosing regimen

With severe agitation, fear, anxiety, treatment begins with a dose of 3 mg / day, quickly increasing the dose until a therapeutic effect is obtained.

In the treatment of epilepsy -2-10 mg / day.

For the treatment of alcohol withdrawal - inside, 2-5 mg / day.

The average daily dose is 1.5-5 mg, it is divided into 2-3 doses, usually 0.5-1 mg in the morning and afternoon and up to 2.5 mg at night. In neurological practice, in diseases with muscle hypertonicity, 2-3 mg are prescribed 1-2 times / day.

The maximum daily dose is 10 mg.

In order to avoid the development of drug dependence during course treatment, the duration of phenazepam is 2 weeks (in some cases, the duration of treatment can be increased to 2 months). With the abolition of phenazepam, the dose is reduced gradually.

Side effects

From the side of the central nervous system and peripheral nervous system: at the beginning of treatment (especially in elderly patients) - drowsiness, fatigue, dizziness, decreased ability to concentrate, ataxia, disorientation, unsteady gait, slow mental and motor reactions, confusion; rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements (especially at high doses), mood depression, dystonic extrapyramidal reactions (uncontrolled movements, including the pelvis), asthenia, muscle weakness, dysarthria, epileptic seizures (in ballroom epilepsy); extremely rarely - paradoxical reactions (aggressive outbursts, psychomotor agitation, fear, suicidal tendencies, muscle spasm, hallucinations, agitation, irritability, anxiety, insomnia).

From the side of the hematopoietic organs: leukopenia, neutropenia, agranulocytosis (chills, pyrexia, sore throat, excessive fatigue or weakness), anemia, thrombocytopenia.

From the digestive system: dry mouth or drooling, heartburn, nausea, vomiting, decreased appetite, constipation or diarrhea; abnormal liver function, increased activity of hepatic transaminases and alkaline phosphatase, jaundice.

From the genitourinary system: Urinary incontinence, urinary retention, impaired renal function, decreased or increased libido, dysmenorrhea.

Allergic reactions: skin rash, itching.

Others: addiction, drug dependence; lowering blood pressure (BP); rarely - visual impairment (diplopia), weight loss, tachycardia.

With a sharp decrease in the dose or discontinuation of the intake, a withdrawal syndrome (irritability, nervousness, sleep disturbances, dysphoria, spasm of the smooth muscles of the internal organs and skeletal muscles, depersonalization, increased sweating, depression, nausea, vomiting, tremor, perception disorders, incl. hyperacusis, paresthesia, photophobia; tachycardia, convulsions, rarely acute psychosis).

Overdose

Interaction with other drugs

special instructions

Release form:

Storage conditions

Best before date

Conditions for dispensing from pharmacies:

Claims from buyers are accepted by the manufacturer:

Phenazepam is a psychotropic drug under special state control. This is not harmless activated charcoal and not cough lozenges, but the most tranquilizer that has a pronounced anxiolytic (“anti-anxiety”), hypnotic, sedative (sedative), anticonvulsant and central muscle relaxant (reducing the tone of skeletal muscles) action. The international non-proprietary name of this drug - bromd- is difficult to remember even after repeated reading, but this, in fact, is not required: the main thing is to know that phenazepam belongs to the psychotropic drugs of the benzodiazepine series and has all the features inherent in benzodiazepines, while having several exclusive pharmacological "trump cards".

Phenazepam inhibits the activity of the central nervous system, pointwise affecting such brain structures as the thalamus and hypothalamus, as well as the limbic system. In close cooperation with gamma-aminobutyric acid (GABA), phenazepam, which has the ability to potentiate the action of the latter, enhances pre- and postsynaptic inhibition of the transmission of nerve impulses. Activation of GABA receptors consists in the stimulation of the GABA-benzodiazepine-chlorionophore prescription complex of benzodiazepine receptors by phenazepam. As a result, the sensitivity of GABA receptors to this mediator increases, thereby enhancing the inhibitory effect of GABA on the central nervous system. At the psychological level, the patient has a decrease in emotional stress, anxiety, anxiety, glimpses of a positive attitude, depression and obsessive fears go away.

Phenazepam is available in two dosage forms: tablets and solution for intravenous and intramuscular injection, and the solution is used mainly for the relief of withdrawal symptoms and, if necessary, the rapid removal of anxiety and psychomotor agitation. The drug is taken under the strict supervision of a doctor in the dosages prescribed by him. In severe (clinical) depression, the drug is even dangerous, because. may induce the patient to commit suicide. Elderly patients or persons with a weakened body as a result of any chronic disease should take phenazepam with extreme caution. The risk of developing certain side effects is determined by the individual response to the drug of each individual patient, the dose and duration of the therapeutic course. After discontinuation of the drug, unwanted side effects disappear. Long-term use of phenazepam in significant doses, the actual abuse of it, is fraught with the development of drug dependence, which is true for any benzodiazepine. Abrupt withdrawal of the drug is also undesirable, because. can provoke the so-called rebound syndrome: in relation to phenazepam, its sign will be increased depression, irritability, hyperhidrosis - i.e. all those symptoms that were successfully defeated during the medication course.

Pharmacology

Anxiolytic agent (tranquilizer) of the benzodiazepine series. It has an anxiolytic, sedative-hypnotic, anticonvulsant and central muscle relaxant effect.

Enhances the inhibitory effect of GABA on the transmission of nerve impulses. Stimulates benzodiazepine receptors located in the allosteric center of postsynaptic GABA receptors of the ascending activating reticular formation of the brain stem and intercalary neurons of the lateral horns of the spinal cord; reduces the excitability of the subcortical structures of the brain (limbic system, thalamus, hypothalamus), inhibits polysynaptic spinal reflexes.

The anxiolytic effect is due to the effect on the amygdala complex of the limbic system and is manifested in a decrease in emotional stress, weakening anxiety, fear, anxiety.

The sedative effect is due to the effect on the reticular formation of the brain stem and nonspecific nuclei of the thalamus and is manifested by a decrease in the symptoms of neurotic origin (anxiety, fear).

It practically does not affect the productive symptoms of psychotic genesis (acute delusional, hallucinatory, affective disorders), rarely there is a decrease in affective tension, delusional disorders.

The hypnotic effect is associated with inhibition of the cells of the reticular formation of the brain stem. Reduces the impact of emotional, vegetative and motor stimuli that disrupt the mechanism of falling asleep.

The anticonvulsant effect is realized by enhancing presynaptic inhibition, suppresses the spread of the convulsive impulse, but the excited state of the focus is not removed. The central muscle relaxant effect is due to the inhibition of polysynaptic spinal afferent inhibitory pathways (to a lesser extent, monosynaptic ones). Direct inhibition of motor nerves and muscle function is also possible.

Pharmacokinetics

Release form

Tablets are white, ploskotsilindrichesky, with a facet.

Excipients: lactose, potato starch, gelatin, calcium stearate, stearic acid.

10 pieces. - cellular contour packings (5) - packs of cardboard.

Dosage

In / m or / in (jet or drip): for the rapid relief of fear, anxiety, psychomotor agitation, as well as autonomic paroxysms and psychotic conditions, the initial dose is 0.5-1 mg, the average daily dose is 3-5 mg, in severe cases - up to 7-9 mg.

Inside: for sleep disorders - 250-500 mcg 20-30 minutes before bedtime. For the treatment of neurotic, psychopathic, neurosis-like and psychopathic conditions, the initial dose is 0.5-1 mg 2-3 times a day. After 2-4 days, taking into account the effectiveness and tolerability, the dose can be increased to 4-6 mg / day. With severe agitation, fear, anxiety, treatment begins with a dose of 3 mg / day, quickly increasing the dose until a therapeutic effect is obtained. In the treatment of epilepsy - 2-10 mg / day.

For the treatment of alcohol withdrawal - inside, 2-5 mg / day or / m, 500 mcg 1-2 times / day, with vegetative paroxysms - / m, 0.5-1 mg. The average daily dose is 1.5-5 mg, it is divided into 2-3 doses, usually 0.5-1 mg in the morning and afternoon and up to 2.5 mg at night. In neurological practice, in diseases with muscle hypertonicity, 2-3 mg are prescribed 1-2 times / day. The maximum daily dose is 10 mg.

In order to avoid the development of drug dependence during course treatment, the duration of phenazepam is 2 weeks (in some cases, the duration of treatment can be increased to 2 months). With the abolition of phenazepam, the dose is reduced gradually.

Interaction

With the simultaneous use of phenazepam reduces the effectiveness of levodopa in patients with parkinsonism.

Phenazepam may increase the toxicity of zidovudine.

There is a mutual enhancement of the effect with the simultaneous use of antipsychotic, antiepileptic or hypnotic drugs, as well as central muscle relaxants, narcotic analgesics, ethanol.

Inhibitors of microsomal oxidation increase the risk of developing toxic effects. Inducers of microsomal liver enzymes reduce the effectiveness.

Increases the concentration of imipramine in the blood serum.

With simultaneous use with antihypertensive agents, it is possible to increase the antihypertensive effect. Against the background of the simultaneous appointment of clozapine, it is possible to increase respiratory depression.

Side effects

From the side of the central nervous system and peripheral nervous system: at the beginning of treatment (especially in elderly patients) - drowsiness, fatigue, dizziness, decreased ability to concentrate, ataxia, disorientation, gait instability, mental and motor reactions slowdown, confusion; rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements (especially at high doses), mood depression, dystonic extrapyramidal reactions (uncontrolled movements, including the eyes), asthenia, myasthenia gravis, dysarthria, epileptic seizures (in patients with epilepsy); extremely rarely - paradoxical reactions (aggressive outbursts, psychomotor agitation, fear, suicidal tendencies, muscle spasm, hallucinations, agitation, irritability, anxiety, insomnia).

On the part of the hematopoietic organs: leukopenia, neutropenia, agranulocytosis (chills, hyperthermia, sore throat, excessive fatigue or weakness), anemia, thrombocytopenia.

From the digestive system: dry mouth or salivation, heartburn, nausea, vomiting, loss of appetite, constipation or diarrhea; abnormal liver function, increased activity of hepatic transaminases and alkaline phosphatase, jaundice.

From the genitourinary system: urinary incontinence, urinary retention, impaired renal function, decreased or increased libido, dysmenorrhea.

Allergic reactions: skin rash, itching.

Local reactions: phlebitis or venous thrombosis (redness, swelling or pain at the injection site).

Others: addiction, drug dependence; decrease in blood pressure; rarely - visual impairment (diplopia), weight loss, tachycardia.

With a sharp decrease in the dose or discontinuation of the intake, a withdrawal syndrome (irritability, nervousness, sleep disturbances, dysphoria, spasm of the smooth muscles of the internal organs and skeletal muscles, depersonalization, increased sweating, depression, nausea, vomiting, tremor, perception disorders, incl. hyperacusis, paresthesia, photophobia; tachycardia, convulsions, rarely - acute psychosis).

Indications

Neurotic, neurosis-like, psychopathic and psychopathic and other conditions (irritability, anxiety, nervous tension, emotional lability), reactive psychoses and senesto-hypochondriac disorders (including those resistant to the action of other anxiolytic drugs (tranquilizers), obsession, insomnia, withdrawal syndrome (alcoholism, substance abuse), status epilepticus, epileptic seizures (of various etiologies), temporal and myoclonic epilepsy.

In extreme conditions - as a means of facilitating overcoming feelings of fear and emotional stress.

As an antipsychotic agent - schizophrenia with hypersensitivity to antipsychotic drugs (including febrile form).

In neurological practice - muscle rigidity, athetosis, hyperkinesis, tic, autonomic lability (sympathoadrenal and mixed paroxysms).

In anesthesiology - premedication (as a component of introductory anesthesia).

Contraindications

Coma, shock, myasthenia gravis, angle-closure glaucoma (acute attack or predisposition), acute alcohol poisoning (with weakening of vital functions), narcotic analgesics and hypnotics, severe COPD (possibly increased respiratory failure), acute respiratory failure, severe depression (may manifest suicidal tendencies) I trimester of pregnancy, lactation, children and adolescents under 18 years of age (safety and efficacy have not been determined), hypersensitivity (including to other benzodiazepines).

Application features

Use during pregnancy and lactation

During pregnancy, the use is possible only for health reasons. It has a toxic effect on the fetus and increases the development of congenital malformations when used in the first trimester of pregnancy. Admission at therapeutic doses in later pregnancy may cause CNS depression in the newborn. Chronic use during pregnancy can lead to physical dependence with the development of withdrawal syndrome in the newborn. Children, especially at a younger age, are very sensitive to the CNS depressant effects of benzodiazepines.

Use immediately before or during labor may cause respiratory depression, reduced muscle tone, hypotension, hypothermia, and poor suckling (sluggish baby syndrome) in the newborn.

Application for violations of liver function

Application for violations of kidney function

Use with caution in renal failure.

Use in children

special instructions

Use with caution in hepatic and / or renal insufficiency, cerebral and spinal ataxia, a history of drug dependence, a tendency to abuse psychoactive drugs, hyperkinesis, organic brain diseases, psychosis (paradoxical reactions are possible), hypoproteinemia, sleep apnea (established or suspected ) in elderly patients.

With renal and / or liver failure and long-term treatment, it is necessary to monitor the picture of peripheral blood and the activity of liver enzymes.

In patients who have not previously taken psychoactive drugs, there is a therapeutic response to the use of phenazepam at lower doses, compared with patients taking antidepressants, anxiolytics or suffering from alcoholism.

Like other benzodiazepines, it has the ability to cause drug dependence with long-term use in high doses (more than 4 mg / day). With a sudden cessation of administration, a withdrawal syndrome may occur (including depression, irritability, insomnia, increased sweating), especially with prolonged use (more than 8-12 weeks). If unusual reactions occur in patients such as increased aggressiveness, acute states of arousal, fear, suicidal thoughts, hallucinations, increased muscle cramps, difficulty falling asleep, superficial sleep, treatment should be discontinued.

In the process of treatment, patients are strictly prohibited from using ethanol.

The efficacy and safety of the drug in patients under 18 years of age has not been established.

In case of overdose, severe drowsiness, prolonged confusion, decreased reflexes, prolonged dysarthria, nystagmus, tremor, bradycardia, shortness of breath or shortness of breath, decreased blood pressure, coma are possible. Gastric lavage, activated charcoal are recommended; symptomatic therapy (maintenance of breathing and blood pressure), the introduction of flumazenil (in a hospital setting); hemodialysis is ineffective.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Hello, today we will talk with you, perhaps, about the most famous fear pill we have called phenazepam. I want to say right away that the article is purely educational, i.e. I am not agitating anyone to take or not to take this drug, but simply share my subjective opinion. So, I think that it is most logical to start the article with general information about this drug, and at the end I will write about my attitude to phenazepam and publish reviews of those people who directly took it.

What it is?

Phenazepam is a highly active tranquilizer that has a pronounced anticonvulsant, hypnotic and muscle relaxant (reducing the tone of skeletal muscles) action.

Release form

One tablet: 0.5 mg, 1 mg and 2.5 mg.

One plate contains 10 or 25 tablets. In one carton 2 or 5 plates (25 or 10 tablets).

Polymer jars (50 tablets each). In one carton - 1 jar.

Indications for use

I think that from the definition at the beginning of the article it is clear what these magic pills are directed against, but for show I will write again:

• conditions that are accompanied by fear;
• emotional instability;
• autonomic dysfunction and sleep disorders;
• prevention of states of fear and emotional stress;
• anticonvulsant.

You can familiarize yourself with the testimony in more detail.

Contraindications

• hypersensitivity;
• angle-closure glaucoma (predisposition or acute attack);
• severe chronic obstructive pulmonary disease;
• severe depression (suicidal tendencies are observed);
• during breastfeeding;
• coma;
• myasthenia gravis;
• severe alcohol poisoning, sleeping pills;
• pregnancy;
• adolescence and children under 18 years of age;

Side effects

Central and peripheral nervous system:

Most often: at the beginning of treatment (especially in the elderly) - drowsiness, dizziness, ataxia, unsteady gait, confusion, feeling tired, decreased ability to concentrate, disorientation, slowing mental and motor reactions.

Rarely: headache, depression, memory loss, mood depression, asthenia (fatigue), dysarthria (speech difficulty), euphoria, tremor, impaired coordination of movements (especially at high doses), dystonic extrapyramidal reactions (uncontrolled movements, incl. eye), muscle weakness, epileptic seizures (in patients with epilepsy).

Very rare: various paradoxical reactions that are directly opposite to the action of the drug (fear, anxiety, muscle spasms, etc.).

Digestive system

Dry mouth or drooling, nausea, decreased appetite, abnormal liver function, jaundice, heartburn, vomiting, constipation or diarrhea.

Hematopoietic organs

Leukopenia (decrease in the number of white blood cells in the blood), chills, sore throat, weakness, thrombocytopenia (decrease in the number of platelets), neutropenia (decrease in the number of neutrophils), pyrexia, excessive fatigue, anemia (decrease in the number of functional red blood cells) .

allergic reactions

Itching, skin rash.

genitourinary system

Urinary incontinence, impaired renal function, dysmenorrhea, urinary retention, decreased or increased libido.

Other

Most often: drug dependence, addiction.

Rarely: blurred vision, tachycardia (rapid heartbeat), weight loss.

withdrawal syndrome

Most often: irritability, sleep disturbances, spasm of smooth muscles of internal organs and skeletal muscles, increased sweating, nausea, tremors, convulsions, perceptual disturbances, nervousness, dysphoria (low mood), depersonalization, depression, vomiting, tachycardia.

Rare: acute psychosis.

Overdose

Symptoms

Severe drowsiness, decreased reflexes, nystagmus, bradycardia, shortness of breath, coma, marked depression of consciousness, cardiac and respiratory activity, prolonged confusion, prolonged dysarthria, tremor, shortness of breath.

Treatment

Symptomatic therapy, administration of activated charcoal, maintenance of respiratory and cardiovascular activity, gastric lavage, control of vital body functions.

Specific antagonist

Flumazenil (in a hospital setting) - in / in 0.2 mg (if necessary - up to 1 mg) in 5% glucose solution or 0.9% sodium chloride solution.

Instructions for use

The drug is released by prescription and is administered orally.

A single dose of phenazepam is usually 0.0005 - 0.001 g (0.5 - 1 mg), and for sleep disorders 0.00025 - 0.0005 g (0.25 - 0.5 mg) 20-30 minutes before bedtime.

For the treatment of neurotic, psychopathic, neurosis-like and psychopathic conditions, the initial dose is 0.0005-0.001 g (0.5-1 mg) 2-3 times a day. After 2-4 days, taking into account the effectiveness and tolerability of the drug, the dose can be increased to 0.004-0.006 g per day (4-6 mg), the morning and daily dose is 0.0005-0.001 g, at night 0.0025 g. agitation, fear, anxiety, treatment begins with a dose of 0.003 g (3 mg) per day, rapidly increasing the dose until a therapeutic effect is obtained.

In neurological practice, in diseases with increased muscle tone, the drug is prescribed at 0.002 - 0.003 g (2 - 3 mg) once or twice a day.

The average daily dose of phenazepam is 0.0015 - 0.005 g (1.5 - 5 mg), it is divided into 3 or 2 doses, usually 0.5 - 1.0 mg in the morning and afternoon and up to 2.5 mg at night. The maximum daily dose is 0.01 g (10 mg). The duration of the course of treatment is up to 2 months. When the drug is discontinued, the dose is reduced gradually.

Phenazepam is compatible with other drugs (hypnotics, anticonvulsants, etc.), however, it is necessary to take into account the mutual potentiation of their action.

Price

Price in Russia: about 80 rubles.

Price in Belarus: about 20,000 rubles.

And you can see the availability of the drug in pharmacies in Russian cities.

Reviews

Feedback that I collected on various forums (including forums dedicated to social phobia).

Review #1: I took phenazepam for about a year, he helped me a lot, I finally felt like a man, got a job. But it is almost impossible to refuse it - the longer you take it, the less you cope with situations that you used to cope with without it. You become calm like a “tank”, and without it then it’s just a nightmare, any rustle frightens you, it becomes unbearable and you take the pill again. I started taking 1 tablet 2 times a week, then 2. For 2 days it gives a relaxing effect. By coincidence, I had to give it up, the waste was terrible, but I managed, but without it I’m sitting at a “broken trough” again, I want to start taking it again, because I already forgot how it feels to be calm ... I agree that this is probably the only drug that soothes almost completely, but the "fee" for it is high. Here is such a dilemma, to get hooked on it thoroughly without thinking about the consequences, or to cope on your own, everyone chooses for himself.

Feedback #2: Phenazepam is a complete tin. I talked with doctors, they say that this is a drug of the past generation (it is clear, it was still in Soviet times). It contains a substance that accumulates in the body, and it is not excreted (!). All this accumulates in the tissues and naturally does not make the internal organs healthier. In addition, dependence on it appears quickly, it is impossible to get off it. I saw all this with my own eyes in my relative, how she went to a psycho. some dispensary where she was prescribed it and every few months she went there for a couple of days, they did a procedure to remove dependence on him, really, like drug addicts. And then after a couple of weeks she started drinking it again and so on in a circle. Moreover, this was officially established - they are prescribed, and then removed with other drugs and taken again. There were many bad changes, as they later said, precisely against the background of phenazepam. It changes the pressure, so it pumps from it, it is harmful of course for the vessels, primarily the brain, which is why changes can occur with long-term use - up to glitches. Of course, it's up to you to decide, but in my opinion now there are safer drugs, of a new generation, which, at least elementarily, do not plant the liver.

Review #3: I was prescribed phenazepam only in a private clinic. The rest of the doctors did not advise at all, tk. getting used to it (already written) and a person, in order to maintain the desired effect, must constantly increase the dose. It is beneficial for the private sector. In this way, they keep the patient on a short leash: they constantly adjust the dose, assure that the treatment is not finished and cut money from the client. Also, it is bad for the heart. In general, I took this rubbish in meager doses for a week and quit ...

Review #4: This morning I drank a wheel of phenazepam, initially dry mouth and when I went out to smoke it was cold, but nothing seemed to be noticed, but after half an hour I went to the store, again for cigarettes (to the supermarket) and calmly went in, bought with an important look. Even the formidable guards from whom I usually turn away, in fact, did not affect me in any way, I don’t know ... maybe it was just an illusion or a hair dryer works like that.

Review #5: There was a time when I drank phenazepam according to the situation. Social phobia practically did not decrease from him, it was just a special state, as if you were “in a dream”.

Review #6: I have been taking phenazepam 1.5 mg for over a year now and do not feel the need to increase the dose. I tried to reduce slowly, but after a decrease of more than 0.5 mg, I feel an increase in anxiety and muscle tension. I just don't know of any other way to relieve these symptoms. Although I really want to do without any psychotropic drugs. I went to several psychotherapists, but it was not possible to solve this problem.

Review #7: Clogs the liver. It is addictive and as a result - an increase in the dose. With alcohol - up to complete loss of memory for some segments of events. Memory sits forever. When you try to get off, the fun begins: irritability, aggression, breakdowns, nightmares in a dream. I got off with expensive vodka gradually. For 9 years now I have not touched either a hair dryer or vodka, but sometimes those days make themselves felt. The memory was phenomenal, I tried to restore it, but I could not restore it to its former level. Sometimes everything is fine and suddenly a memory gap. I don’t remember where I put the rag or some other nonsense.

Review #8: I drank phenazepam a couple of times in my life. The reaction is strange. Firstly, when I start to fall asleep, for some reason, the muscles begin to contract convulsively, through a dream I lie and twitch and wake up myself from these twitches. In the morning, it’s generally tin ... Parts of the body do not obey. I can walk and my legs can give way, then I can’t take a cup at all - I look at it, but my hand does not rise. Creepy.

Review #9: I drank more than once. It helps me a lot. And now, sometimes, I drink occasionally. For example, once every two weeks I can drink if I can’t sleep for a long time or I have an important meeting. You can get hooked on it, but believe me, it won’t take a week or even two or three…

Review #10: In her youth she dabbled in phenazepam, relanium, sibazon. I don't recommend it very much. When the soul hurts and all that - you take a pill, like in a cocoon, and you are calm as an oyster. And then you notice that there are lapses in memory. Now, over the years, I regret it, because the brain obviously wedges sometimes. Some events of the past cannot be restored - they were in reality or I invented it myself. Some events tell me and I sincerely wonder what happened to me. So take something softer.

Review #11: Phenazepam should not be taken much and often. I got used to it already after three or four days of taking it. It really is a drug. Without him, then everything seems so terrible and gloomy, but with him it’s so cozy and calm ...

Review #12: And about getting used to phenazepam. I drank at night in a row for three months. First 0.5, then 0.25. It was at the direction of the doctor. No addiction. Now I drink only when necessary, that is, not in courses. It still helps.

Review #13: Guys! I don’t want to drink phenazepam to the enemy ... I started drinking it 7-8 years ago, the doctors did not warn that you could get hooked. And I drank it (then it helped a lot with anxiety) at 2 mg. in a day. But when I naively stopped drinking it after 6 months of its heavy use, I realized that I got it ... I still drink, that I just haven’t tried - there’s no sense, but the nervous system, liver, heart, the body as a whole really planted ... Don’t try to drink it - it helps very well at first, and then you won’t notice how you will eat it all the time and reproach yourself for starting to drink it ... Believe me - I am writing from my own bitter experience ...

Review #14: I have been taking phenazepam for several years, but in very reasonable doses (1 mg.), And only at night. Shorter packs (50) tab. enough for 4-5 months. I recently took a break for 2.5 months. The most important thing is not to abuse it, not to increase the dose, and drink in extreme cases, and then you can live. Although I started taking it almost every day (the neurologist wrote it out, due to a depressed state in the morning). Then, based on the experience of taking it, I decided not to abuse it, although some kind of dependence nevertheless appeared. So my advice is to use it only in extreme cases at night, and in minimal doses.

Review #15: Of course, phenazepam will not change your life. It will only temporarily save you from critical moments (panic attacks, tantrums, hangovers, etc.). I myself, taking it for about 10 years, try not to go beyond 1 - 1.5 tablets per week. 6 pieces can be drunk once (well, maybe twice) in a lifetime. Next is replanting on pills, which could not be worse ...

Review #16: Hairdryer is not satisfied with the fact that this is a single-acting drug. He doesn't heal. And it is better to drink it immediately before disturbing social. situations. Perhaps my mistake was that I drank the course, gradually increasing the dose. The addiction came very quickly.

Review #17: I personally have been taking it for about 5-6 years now. On the second day after the evening reception, it will relax, and, as it were, there will be a slight euphoria. But over time, this effect will weaken, i.e. the body becomes addictive, the result - it is necessary to increase the dose, as with drugs.

Review #18: I have never taken phenazepam, but my mother started taking it a long time ago without our knowing it. Now she has developed a strong addiction, her consciousness and reason have gone crazy. They tried to throw away the pills from her, but according to her sources, she bought them again and drank. Now our life is hell. Tip: if you really need a tranquilizer, then drink valerian better, but it’s better not to touch phenazepam at all.

My attitude to phenazepam

To be honest, I am rather negative about drug treatment, because if you just constantly swallow pills, then in fact nothing will change, you will only muffle the symptoms, but you will not get rid of the problem itself. Another thing is when they are used in conjunction with psychotherapy, in such cases, it seems to me, there should be a result. But again, let me remind you that I am not a doctor and this is just my subjective reasoning.

Now let's move on to phenazepam. Judging by the reviews, you can get hooked on it very quickly, and it acts on the principle of a drug - over time, you will have to increase the dose each time in order to achieve the desired effect. Many write about memory lapses, and I think that it is not without reason that phenazepam is a prohibited drug in some countries. Therefore, personally, I, most likely, would never try this rubbish (unless in some hopeless situation), which I advise you. If you really want to overcome your fear, then phenazepam is clearly not for you.