Ribomunil analogues of the active substance. Ribomunil (Ribomunyl ®). Terms and conditions of storage

Ribomunil is a combined immunostimulating drug of bacterial origin.

The composition of the drug contains weakened pathogenic microorganisms that cause infections of the respiratory tract, ear, throat, nose and larynx. Ribomunil stimulates the body's immune system to produce antibodies that protect against pathogenic microbes.

The drug is widely used as a prophylactic for frequent sinusitis, runny nose, inflammatory processes in the tonsils, bronchi, lung tissues, chronic respiratory disease, as well as chronic and acute pharyngitis.

Ribomunil stimulates some humoral and cellular components of the immune system (provides non-specific and specific stimulation), namely:

• enhances phagocytosis (stimulates the phagocytic activity of polymorphonuclear neutrophils and macrophages);
• stimulates T-lymphocytes;
• stimulates the production of serum and secretory immunoglobulins (Ig A 11S).

The use of the drug as a basic immunotherapy allows you to effectively influence the immune status of patients with recurrent respiratory tract infections - while reducing the frequency, severity and duration of episodes of infections, as well as the need for intensive antibiotic therapy, corticosteroids.

Ribomunil helps the body to produce specific serum and secretory antibodies to bacterial pathogens, which are the most common.

Active substances in 1 tablet:

• Bacterial ribosomes titrated to 70% ribonucleic acid - 0.25 (1/3 dose) or 0.75 mg (including ribosomes: Klebsiella pneumoniae - 3.5 parts, Haemophilus influenzae - 0.5 parts, Streptococcus pyogenes - 3 parts, Streptococcus pneumoniae - 3 parts);
• Proteoglycans of the membrane part of Klebsiella pneumoniae - 0.375 (1/3 dose) or 1.125 mg (15 parts).
• Additional components - hydrophobic colloidal silicon, magnesium stearate, sorbitol.

Indications for use

What helps Ribomunil? The drug is prescribed in the following cases:

• Recurrent and protracted infections of the upper respiratory tract (sinusitis, rhinitis, tonsillitis, laryngitis, pharyngitis, otitis)
• Respiratory tract infections (infection-dependent bronchial asthma, tracheitis, chronic bronchitis, pneumonia)

The use of the drug as part of complex treatment increases the effectiveness and reduces the duration of therapy, significantly reducing the need for the use of bronchodilators and / or antibiotics, increasing the period of remission.

It is also used as a prophylactic for infectious diseases (including recurrent ones) in patients who are at risk (long-term ill, often ill, with chronic bronchitis, chronic pathology of the ENT organs, bronchial asthma, before the start of winter or autumn season).

Instructions for use Ribomunil and dosage

The dosage of the drug is the same for all ages, but you can give the child medicine only from 6 months!

Ribomunil is taken once a day half an hour before meals, preferably in the morning.

A single dosage is 750 mg. If you bought 250 mg tablets, then give the child 3 tablets at once or 1 tablet of 750 mg. Tablets should not be chewed, but should be washed down with water (at least half a glass).

At an early age, it is preferable for children to prescribe the drug in the form of granules. One bag of granules (750 mg) is dissolved in half a glass of warm boiled water and given to the child. It is not necessary to force him to drink everything at once, the medicine can be given to the baby in small portions for 2-3 doses.

• the first month of therapy / for prophylactic purposes: the first 4 days of each week for a course of 3 weeks;
• subsequent 2-5 months: monthly for the first 4 days.

The frequency of repetition of preventive courses: three-month - 2 times a year, lasting 6 months - 1 time per year.

Side effects

The appointment of Ribomunil may be accompanied by the following side effects:

• Digestive system: nausea, increased salivation, vomiting, diarrhea;
• Hypersensitivity reactions: angioedema, urticaria;
• In isolated cases - transient hypersalivation at the beginning of treatment.

Contraindications

Ribomunil is contraindicated in the following cases:

• hypersensitivity to the drug or any of its components in history;
• autoimmune diseases.

Lactating and pregnant women, due to insufficient data on the safety and efficacy of therapy, can be prescribed the drug only after an individual assessment by the doctor of the benefit / risk ratio.

Overdose

When conducting toxicological studies, the administration of Ribomunil to rats at doses 4,500–50,000 times higher than the therapeutic dose for humans did not cause any toxic effects.

Clinical practice indicates that an overdose of the drug does not cause specific clinical symptoms.

Ribomunil analogues, list of drugs

If necessary, you can replace Ribomunil with an analogue according to the ATX code - these are drugs:

1. Actinolysate,
2. Bestim,
3. Imudon.

When choosing analogues, it is important to understand that the instructions for use of Ribomunil, the price and reviews of drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

The price for 1 pack in pharmacies starts from 352 rubles.

Keep out of the reach of children at a temperature not exceeding 25 ° C.

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Now it's impossible to get it! Called all pharmacies and online pharmacies! They answer that he has not been in Russia for a long time at all! Friends are resting in Turkey, she asked me to look, also not! They show them a box (photo), and they answer that they have never had this drug!!! So where do you get it???

Only thanks to Ribomunil we forgot what it is to get sick every month. single bronchitis. Nephew also helped a lot.

Before going to the kindergarten, the pediatrician advised us Ribomunil. You know, a lot of reviews about Ribomunil and re-read. Many praised the drug, some, on the contrary, found fault with it, but as you know, each organism has its own perception of any medication. Ribomunil is a kind of vaccine, and we did all the vaccinations, did not refuse. Started taking... Before going to the kindergarten, the pediatrician advised us Ribomunil. You know, a lot of reviews about Ribomunil and re-read. Many praised the drug, some, on the contrary, found fault with it, but as you know, each organism has its own perception of any medication. Ribomunil is a kind of vaccine, and we did all the vaccinations, did not refuse. Started taking a couple of months before going to the garden. I knew perfectly well that in kindergarten a child would get sick many times while adapting to a new environment. But! For 6 months in the garden, we got sick only once, and that one did without a temperature!!! I think it's an indicator. Therefore, Ribomunil is a very effective and necessary drug!

Thanks

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Ribomunil - dosage, composition and form of release

As an active ingredient, Ribomunil granules and tablets contain pure ribosomes and parts of cell membranes of various pathogenic microorganisms that cause infections of the respiratory tract and ENT organs, such as Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes and haemophilus influenzae.

Ribosomes are special intracellular structures (organelles) that carry out the synthesis of proteins and are present in every cell of any living creature - both humans, animals, birds, insects, and microbes. But in each species of living beings, ribosomes have certain characteristics and carry species-specific antigens that allow them to be clearly identified. Thus, the ribosomes isolated from microbial cells carry antigens, thanks to which the human immune system can "recognize" the pathogenic microorganism and develop antibodies against it. As an additional substrate that carries microbial antigens, Ribomunil uses particles of cell membranes of the same bacteria, which, in fact, accelerate the production of antibodies.

However, neither a ribosome nor a cell membrane fragment is capable of causing an infectious disease, they can only activate the immune system and force it to produce a large amount of antibodies that will circulate in the blood and protect a person from the possible penetration of a full-fledged microbe. That is, purified ribosomes with membrane particles are a vaccine that is used to develop immunity to infections of the respiratory tract and ENT organs.

Ribomunil tablets are available in two dosages - 250 micrograms and 750 micrograms of ribosome fractions of pathogenic microbes. Usually the amount of the active ingredient in 250 mcg is indicated as 1/3 of a single dosage, and 750 mcg as 1 dose. This means that for a single dose, a person will need either 3 tablets of 250 micrograms or 1 tablet of 750 micrograms. The amount of cell membranes in tablets with 750 μg of ribosomes is 1.125 mg, and with 250 μg - 0.375 μg. However, only the amount of ribosomal fractions is always used to indicate the dosages of Ribomunil, and the content of cell membranes is not indicated, since this lengthens and complicates speech. Also, for simplicity and clarity, tablets containing 750 μg of ribosomal fractions and 1.125 mg of membrane particles are referred to as 1-dose tablets. And tablets with 250 µg of the ribosomal fraction and 0.375 µg of membrane particles are referred to as tablets with 1/3 dose.

Granules for the preparation of the solution are available in sachets that contain 1 dose of active ingredients, that is, 750 μg of the ribosomal fraction and 1.125 mg of pathogenic microbial cell membranes. Thus, one sachet of granules is equal to 1 tablet of 750 mg.

As auxiliary components, tablets of both dosages contain silicon, magnesium stearate and sorbitol. Ribomunil granules contain povidone, mannitol, silicon, magnesium stearate and sorbitol as auxiliary components.

Tablets with 1/3 dose are available in packs of 12 pieces, and with 1 dose - 4 pieces. Sachets with granules are packed in boxes of 4 pieces.

Ribomunil - photo

Therapeutic effects of Ribomunil

It is well known that vaccination is the introduction into the human body of weakened but living microbes, or their particles, which cause an immune response with the formation of antibodies. It is these antibodies that have been developed that will protect a person from infection with an infection against which they have been vaccinated for a certain period of time. The duration of the protective effect of vaccination depends on the properties of the microbe-causative agent of the infection.

Since Ribomunil contains various parts of pathogenic microbes that most often cause infections of the respiratory and ENT organs, its intake is a kind of vaccination. After all, particles of bacteria enter the human body, on which protective antibodies are produced. Then, when a real infectious agent enters the body, ready-made, already existing antibodies will be able to destroy it very quickly, since it will no longer be necessary to spend some time to develop them. It is thanks to this mechanism of action that Ribomunil effectively prevents infections of the respiratory and ENT organs.

However, given that antibodies against the causative agents of these infections circulate in the blood for a short time, in order to maintain immunity to them, it is necessary to take a course of Ribomunil periodically (optimally 1 time in 1-2 years).

In addition to the effect of the oral vaccine, Ribomunil has the properties of a non-specific immunity stimulant. Immunostimulation consists in increasing the activity of macrophages, leukocytes and natural killers, which destroy any pathogenic microorganisms that have fallen on the mucous membranes, for example, viruses, chlamydia, prions, etc.

Thus, the cumulative effect of Ribomunil is achieved - it creates immunity to some infectious agents, while others are destroyed by active immunocompetent cells that are constantly present on the mucous membranes. Therefore, the drug effectively prevents both viral and bacterial infections.

Ribomunil can be used both for the purpose of prevention and in the complex treatment of various chronic or protracted infections of the respiratory and ENT organs. The introduction of Ribomunil into the composition of complex therapy makes it possible to reduce the course of antibiotics and bronchodilators, as well as speed up recovery.

Ribomunil - indications for use

• Rhinitis;
• tonsillitis (tonsillitis);
• Pharyngitis;
• Laryngitis;
• Bronchitis;
• Tracheobronchitis;
• Pneumonia;
• Infection-dependent bronchial asthma.

Ribomunil - instructions for use

General provisions

Tablets must be swallowed whole, without chewing or crushing in other ways, with a small amount of water (at least half a glass). Granules from one sachet should be pre-dissolved in half a glass of water at room temperature. After complete dissolution of the granules, it is necessary to drink the resulting solution.

For children under one year old, it is recommended to give Ribomunil exclusively in the form of granules, since at this age it is difficult for them to swallow tablets. Children older than a year and adults need to choose the dosage form that they best tolerate. For example, if the child normally swallows the pills, and this does not cause him any discomfort, and he does not refuse to take the medicine, then this form of the drug can be used. If the child does not know how to swallow tablets, chews them or refuses to take them, then Ribomunil should be given to him in the form of a solution of granules.

Against the background of the use of Ribomunil in an adult or a child, the temperature may rise and last for 2-3 days, which is one of the manifestations of the therapeutic effect that does not require special treatment or discontinuation of the drug. The temperature caused by the action of Ribomunil usually normalizes on its own within 2 to 3 days. In this situation, the use of antipyretic drugs is not recommended if the temperature is tolerated satisfactorily. However, if the temperature is not well tolerated, then you can knock it down by taking drugs based on paracetamol, ibuprofen or nimesulide. Aspirin should not be given to children, under any circumstances, and is not recommended for adults. Aspirin should only be considered as a backup antipyretic drug for adults, which can only be used when paracetamol, ibuprofen and nimesulide have already been taken but have not been effective.

In addition, while taking Ribomunil, mild and mild symptoms of infectious diseases of the respiratory tract and ENT organs may appear, which also do not require treatment and discontinuation of the drug, and pass on their own. Usually, the appearance of these symptoms is combined with an increase in temperature, and simultaneously with its normalization, they completely disappear.

Ribomunil should be used with caution in people with autoimmune disease, periarteritis nodosa or HIV/AIDS.

The drug interaction of Ribomunil has not yet been established. This means that in combination with Ribomunil, various drugs can be used to treat infectious and inflammatory diseases of the respiratory tract and ENT organs, such as antibiotics, bronchodilators (Fenoterol, Salbutamol, etc.), anti-inflammatory and antipyretic drugs (Nimesulide, Ibuprofen, Panadol, etc.).

Ribomunil - regimen for prevention and during illness

However, if Ribomunil is started during an acute course of a disease of the respiratory tract or ENT organs, then it must be combined with the usual treatment of the infection. Remember that Ribomunil during the period of illness will not replace antibiotics, bronchodilators, expectorants, antipyretics and anti-inflammatory drugs. That is, you will have to take all the necessary treatment and, in addition to it, Ribomunil. If Ribomunil is taken during the period of remission, when the adult or child is healthy, then no additional medications are required.

You can start taking Ribomunil at any time - both during illness, and during the period of recovery or full health.

So, Ribomunil is taken according to the following scheme:
1. In the first week for four days, for example, from Monday to Thursday inclusive (or from Tuesday to Friday, etc.) take daily once a day, 1 tablet of 750 mcg, or one bag of granules or 3 tablets of 250 mcg;

2. In the second and third weeks, take the drug in the same way as in the first, starting from the same day. For example, in the first week they started taking Ribomunil on Wednesday and finished on Saturday, which means that in the second and third weeks you should drink the drug on the same days;
3. Exactly one month later, counting from the first day of taking the drug, you must again take 1 tablet of 750 mcg, or one bag of granules, or 3 tablets of 250 mcg once a day for 4 days. For example, if the first tablet of Ribomunil was taken on May 25, then in a month it will be June 25. So, it is from June 25 that you should start taking 1 dose of Ribomunil once a day for 4 days;
4. It is necessary to repeat the four-day intake of Ribomunil within five months after the first three weeks of treatment. For example, the first pill was taken on May 25th. For the next three weeks, the drug was used 4 tablets on the first 4 days of each week. Then you should take Ribomunil in one dose (1 tablet 750 mcg, 1 sachet of granules or 3 tablets 250 mcg) once a day for 4 days from the 25th to the 28th of June, July, August, September, October and November. You can halve the course and take Ribomunil only until August inclusive, that is, for three months instead of six.

Ribomunil during pregnancy and lactation

Ribomunil for children

General provisions

For young children, it is better to use Ribomunil in the form of granules, which are diluted in water to form a solution. After all, it is easier for children to drink a solution than to swallow a pill. In principle, you can choose the dosage form of Ribomunil for a child (granules or tablets) solely on the basis of his preferences. For example, if a child tolerates tablets well and does not experience any physical or psychological difficulties associated with the need to swallow them, then this dosage form can be used. If the baby does not like to drink pills, then it is recommended to use Ribomunil in granules. In general, the granule option is considered by manufacturers and physicians as a fallback option, which is used when the main form (tablets) cannot be used normally.

During the period of taking Ribomunil in children, as well as in adults, the temperature may rise for 2-3 days and mild symptoms of respiratory tract infections and ENT organs appear. These manifestations pass on their own and do not require special treatment and discontinuation of the drug. The temperature can be brought down, but it is recommended to do this only in cases where the child does not tolerate it satisfactorily.

In order to prevent infectious diseases in the autumn-winter period, it is recommended to start taking Ribomunil in advance, at least in August-September. In addition, practicing pediatricians recommend taking a prophylactic course of Ribomunil 2 to 6 months before the expected date the child will start visiting kindergarten. This will increase the baby's immunity to infections, as a result of which it will be less likely and much easier to get sick.

The use of Ribomunil and excessive stimulation of the immune system

So, in children under 6 - 7 years old, the non-specific link of immunity, which is responsible for the destruction of pathogenic microbes that have fallen on the mucous membranes of the respiratory tract, ENT organs, bladder and urethra, is inferior, and that is why the baby constantly catches colds and suffers from various acute respiratory infections, SARS, influenza and other infections. Another link - specific immunity - is fully developed in a child by the time of birth, and therefore his body produces antibodies to bacteria quite normally, which explains the effectiveness of vaccinations.

That is, the ingestion of almost any virus on the mucous membranes of the upper respiratory tract and respiratory tract will cause a disease in the child. In an adult, with full-fledged non-specific immunity, such accidentally ingested viruses, bacteria or protozoa will be quickly destroyed, and he will not get sick, just 2-3 days he will not feel very good.

Hardening, proper nutrition and other useful procedures will not be able to solve this problem, since it is its physiological feature. If a child is tempered, then he simply will not catch a cold. But with any contact with a pathogenic microbe, he will get sick due to his age characteristics. Since children are in close contact with each other in kindergarten, they are sure to transmit various microbes to others. And since these contacts cannot be limited, a child attending a kindergarten will be constantly sick. If the baby is surrounded by his relatives, then he will rarely get sick, because he is accustomed to family microbes from birth and has already developed immunity. These are the physiological features of this age.

By the age of 5-7, when nonspecific immunity is fully formed, the child will stop getting sick, because, like an adult, pathogenic microbes that accidentally get on mucous membranes will be quickly and effectively destroyed. But before this age, any child will get sick. More or less, longer or shorter - it depends on the individual characteristics of the organism and heredity, but it will hurt.

If, however, the activity of the non-specific link of immunity is artificially increased and maintained in this state for up to 5-7 years, then the child will get sick less, and the course of infections will be easier. This is exactly what Ribomunil does - it enhances non-specific immunity and creates immunity to severe bacterial infections, in a certain sense, making life easier for the child. That is, Ribomunil is an effective and safe assistant that helps the child's body to go through this period of constant illness with the least loss and strain. That is why it is recommended that children who are often and seriously ill be given Ribomunyl in regular courses until they reach 6 or 7 years of age, at which time their non-specific immunity will fully develop and protect them from persistent infections.

Frequent and severe illnesses after the end of the action of Ribomunil are not explained by the fact that the drug overstrained the immune system, after which it fell heavily, but by the fact that the immature nonspecific immune defense remains without support, and the child is susceptible to infection by various microbes. That is, the child begins to get sick precisely because of the expiration of the immunity support, which is still immature and defective.

Ribomunil for children - instructions for use

The drug can be started at any time, regardless of whether the child is completely healthy. However, if the baby is sick, then Ribomunil is used in combination with the usual, standard treatment.

So, Ribomunil in the first month of treatment must be taken one dose during the first four days of three weeks inclusive. That is, the child should be given one dose of the drug from Monday to Thursday in the first, second and third weeks.

Then for the next 2 to 5 months, Ribomunil should be taken one dose per day for the first four days of each month. The first days of each month are the dates on which the very first four tablets were drunk. For example, the first pills were given to the child from the 10th to the 13th of the month, after which he took them for three weeks, 4 days each. This means that after a three-week treatment, from the 10th to the 13th of the next 2-5 months, he will need to be given one dose per day for 4 days (for more details, see the scheme for prevention and during illness or angioedema.

Contraindications for use

• Autoimmune diseases (for example, Hashimoto's thyroiditis, rheumatoid arthritis, etc.);
• Hypersensitivity or individual intolerance to any components of the drug.

Ribomunil - analogues

So, the following medicines are analogues of Ribomunil:

• Arpetolid tablets;
• Arpeflu tablets;
• Bioaron C syrup;
• Broncho-Vaksom adult and children's capsules;
• Poludan nasal drops and lyophilisate for the preparation of drops;
• Ruzam nasal drops and solution for subcutaneous administration;
• Taktivin solution for injection;
• Tsitovir-3 capsules, syrup and powder for oral solution;
• Engystol tablets;
• Estifan tablets;
• Echinacea purpurea extract, oral liquid;
• Echinacea granules, drops and pastilles for oral administration;
• Echinacea lozenges;
• Echinacin liquidum oral solution;
• Echinocor Elixir.

This page provides a list analogues of Ribomunil- these are interchangeable drugs that have similar indications for use and belong to the same pharmacological group. Before you buy analogue of Ribomunil, it is necessary to consult with a specialist regarding the replacement of the drug, study in detail, read and a similar drug.

• Biseptol

  Biseptol are: infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
  respiratory tract infections: chronic bronchitis (exacerbation), pneumocystis pneumonia (treatment and prevention) in adults and children;
  infections of ENT organs: otitis media (in children);
  urinary tract infections: urinary tract infections, soft chancre;
  infections of the gastrointestinal tract: typhoid fever, paratyphoid, shigellosis (caused by sensitive strains of Shigella flexneri and Shigella sonnei); traveler's diarrhea caused by enterotoxic strains of Escherichia coli, cholera (in addition to fluid and electrolyte replacement);
  other bacterial infections (combination with antibiotics is possible): nocardiosis, brucellosis (acute), actinomycosis, osteomyelitis (acute and chronic), South American blastomycosis, toxoplasmosis (as part of complex therapy).
  

• Ecoball

  Ecoball used to treat bacterial infections caused by sensitive microflora: infections of the respiratory tract and upper respiratory tract (sinusitis, pharyngitis, tonsillitis, acute otitis media; bronchitis, pneumonia), genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis) , gastrointestinal tract (enterocolitis, typhoid fever, cholangitis, cholecystitis), infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses), leptospirosis, listeriosis, Lyme disease (borreliosis), dysentery, salmonellosis, salmonellosis, endocarditis (prevention of ).
  

• Ecocyfol

  A drug Ecocyfol intended for use in the treatment of infectious and inflammatory diseases caused by susceptible microorganisms: diseases of the lower respiratory tract (acute and chronic (in the acute stage) bronchitis, pneumonia, bronchiectasis, infectious complications of cystic fibrosis); ENT infections (acute sinusitis); kidney and urinary tract infections (cystitis, pyelonephritis); complicated intra-abdominal infections (in combination with metronidazole); chronic bacterial prostatitis; uncomplicated gonorrhea; typhoid fever, campylobacteriosis, shigellosis, travelers' diarrhea; skin and soft tissue infections (infected ulcers, wounds, burns, abscesses, cellulitis); bones and joints (osteomyelitis, septic arthritis); infections against the background of immunodeficiency (occurring during treatment with immunosuppressive drugs or in patients with neutropenia); prevention and treatment of pulmonary anthrax.
  Children: treatment of complications caused by Pseudomonas aeruginosa in children with pulmonary cystic fibrosis from 5 to 17 years; prevention and treatment of pulmonary anthrax (infection with Bacillus anthracis).
  

• Ecolink

  A drug Ecolink is indicated for the treatment of infectious and inflammatory diseases caused by susceptible microorganisms (primarily staphylococci and streptococci, especially microorganisms resistant to penicillins, as well as allergies to penicillins): sepsis, subacute septic endocarditis, chronic pneumonia, lung abscess, pleural empyema, pleurisy , otitis media, osteomyelitis (acute and chronic), purulent arthritis, postoperative purulent complications, wound infection, infections of the skin and soft tissues (pyoderma, furunculosis, phlegmon, erysipelas).
  

• Ecomed

  Ecomed indicated for the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug: infections of the upper respiratory tract and upper respiratory tract: pharyngitis, tonsillitis, sinusitis, otitis media; lower respiratory tract infections: acute bronchitis, exacerbation of chronic bronchitis, pneumonia, incl. caused by atypical pathogens; infections of the skin and soft tissues: acne vulgaris of moderate severity, erysipelas, impetigo, secondarily infected dermatoses; the initial stage of Lyme disease (borreliosis) - migratory erythema (erythema migrans); urinary tract infections caused by Chlamydia trachomatis (urethritis, cervicitis).
  

• Cefotaxime

  Indications for the use of the drug Cefotaxime are: infectious and inflammatory diseases caused by susceptible microorganisms: infections of the central nervous system (meningitis), respiratory tract and ENT organs, urinary tract, bones, joints, skin and soft tissues, pelvic organs, peritonitis, sepsis, endocarditis; gonorrhea; infected wounds and burns; abdominal infections, salmonellosis, Lyme disease, infections against the background of immunodeficiency, prevention of infections after surgical operations (including urological, obstetric and gynecological, on the organs of the gastrointestinal tract).
  

• colustan

  A drug colustanprescribed as a local treatment of infectious and inflammatory processes in the oral cavity and oropharynx (tonsillitis, pharyngitis, including after tonsillectomy, stomatitis, gingivitis).
  

• Lugol

  Lugol used in the treatment of various types of viral upper respiratory tract (tonsillitis, pharyngitis, tonsillopharyngitis)
  

• Aziklar

  A drug Aziklar used to treat infections caused by microorganisms sensitive to clarithromycin:
  - ENT organs (streptococcal pharyngitis, tonsillitis, acute otitis media, acute sinusitis, sinusitis);
  - respiratory tract (pneumonia, including atypical pneumonia, exacerbation of chronic bronchitis);
  - infections of the skin and soft tissues (folliculitis, furunculosis, impetigo, abscesses, cellulitis, streptoderma, staphyloderma);
  - gastric or duodenal ulcer associated with Helicobacter pylori (mandatory in combination with other drugs).
  

• Azimed tablets

  A drug Azimed used to treat infections caused by microorganisms sensitive to azithromycin: infections of the upper respiratory tract (bacterial pharyngitis / tonsillitis, sinusitis, otitis media); respiratory tract infections (bacterial bronchitis, community-acquired pneumonia); infections of the skin and soft tissues: chronic migratory erythema (the initial stage of Lyme disease), erysipelas, impetigo, secondary pyodermatoses; sexually transmitted infections: uncomplicated urethritis / cervicitis; infections of the stomach and duodenum caused by Helicobacter pylori, as part of complex therapy.
  

• Ampisulbin

  Indications for the use of the drug Ampisulbin are: bacterial infections caused by microorganisms sensitive to the drug - infections of the ear, throat, nose (sinusitis, otitis media, epiglottitis, tonsillitis, pharyngitis); respiratory tract infections (bronchitis, pneumonia); urinary tract infections (cystitis, pyelonephritis); intra-abdominal infections (peritonitis, cholecystitis); infections in obstetrics and gynecology (endometritis, parametritis, salpingo-oophoritis); sepsis; skin and soft tissue infections; bone and joint infections (osteomyelitis, arthritis); gonococcal infections; anaerobic infections. Preoperative prevention of purulent complications in surgery, obstetrics and gynecology (caesarean section, abortion).
  

• Vampilox

  A drug Vampilox It is used to treat infections caused by pathogens sensitive to the action of the drug:
  - ENT organs (sinusitis, otitis media, pharyngitis, tonsillitis, paratonsillar abscess);
  - lower respiratory tract (acute and exacerbation of chronic bacterial bronchitis, bronchopneumonia, bronchiectasis, bronchiolitis, pleurisy, lung abscess, emphysema);
  - urinary system (cystitis, urethritis, acute and exacerbation of chronic pyelonephritis, asymptomatic bacteriuria);
  - skin and soft tissues (abscess, furunculosis, carbuncle, impetigo, cellulitis, infectious dermatoses);
  
  - gastrointestinal tract and hepatobiliary system (peptic ulcer and other diseases associated with Helicobacter pylori, diarrhea);
  - bacterial endocarditis, meningitis, sepsis, brain abscess;
  - prevention of infectious complications during skin flap transplantation and dental interventions.
  

• Yoks solution

  Indications for the use of the solution Yoks are:
  
  
  
  4. With streptococcal tonsillitis, it is used as an additional remedy for antibiotic treatment.

• Yoks spray

  Indications for the use of the spray Yoks are:
  1. Infectious and inflammatory diseases of the oral cavity and pharynx: including tonsillitis, tonsillitis, tonsilopharyngitis, glossitis, stomatitis, aphthae;
  2. For the treatment of the oral cavity and pharynx during surgical interventions on the respiratory tract and oral cavity and in the postoperative period;
  3. For the treatment of infections of the mouth and throat that occur during chemotherapy;
  4. With streptococcal tonsillitis, it is used as an additional remedy for antibiotic treatment.
  

• Ormax capsules

  A drug Ormax It is used to treat diseases caused by microorganisms sensitive to azithromycin:
  - infections of the respiratory system (community-acquired pneumonia, acute bronchitis, chronic bronchitis in the acute stage);
  - infections of ENT organs (tonsillitis, sinusitis, otitis media, pharyngitis);
  - infections of the genitourinary system (urethritis, cervicitis);
  - diseases of the stomach and duodenum caused by H. Pylori;
  - infections of soft tissues and skin (erythema migrans (Lyme disease), erysipelas, impetigo, furunculosis, pyoderma, secondary infection dermatitis).
  

• Ormax suspension

  A drug Ormax prescribed for infections caused by microorganisms sensitive to azithromycin:
  - infections of ENT organs (bacterial pharyngitis/tonsillitis, sinusitis, otitis media);
  - respiratory tract infections (bacterial bronchitis, community acquired pneumonia);
  - skin and soft tissue infections: erythema migrans (the initial stage of Lyme disease), erysipelas, impetigo, secondary pyodermatosis;
  - sexually transmitted infections: uncomplicated and complicated urethritis/cervicitis caused by Chlamydia trachomatis.
  

• Faringomed

  Tablets Faringomed are used to treat inflammatory diseases of the pharynx in adults and children over 5 years of age as part of complex therapy.
  

• Amoxiplus

  A drug Amoxiplus used in the treatment of bacterial infections caused by susceptible microorganisms: severe infections of the throat, nose and ear (such as mastoiditis, peritonsillar infections, epiglotitis and sinusitis with associated severe systemic signs and symptoms); exacerbation of chronic bronchitis (after confirmation of the diagnosis); community-acquired pneumonia; cystitis; pyelonephritis; skin and soft tissue infections, incl. bacterial cellulitis, animal bites, severe dentoalveolar abscesses with widespread cellulitis; bone and joint infections, incl. osteomyelitis; intra-abdominal infections; genital infections in women.
  Prevention of bacterial infections during extensive surgical interventions in the following areas: gastrointestinal tract; pelvic organs chair and neck; bile ducts.
  

• Azitrus

  Indications for the use of the drug Azitrus are:
  
  - Scarlet fever;
  - Infections of the lower respiratory tract (bacterial and atypical pneumonia, exacerbation of chronic pneumonia, bronchitis); Infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses);
  
  
  

  Mode of application:
  
  Inside 1 hour before or 2 hours after meals 1 time per day.
  Adults: for infections of the upper and lower respiratory tract - 500 mg / day for 1 dose for 3 days (course dose - 1.5 g).
  For infections of the skin and soft tissues - 1000 mg / day on the first day for 1 dose, then
  500 mg / day daily from 2 to 5 days (course dose - 3 g).
  In acute infections of the genitourinary organs (uncomplicated urethritis or cervicitis) - once 1 g.
  In Lyme disease (borreliosis) for the treatment of stage I (erythema migrans) - 1 g on the first day and 500 mg daily from 2 to 5 days (course dose - 3 g).
  For peptic ulcer of the stomach and duodenum associated with Helicobacter pylori - 1 g / day for 3 days as part of a combined anti-Helicobacter therapy.
  Children with infections of the upper and lower respiratory tract, skin and soft tissues are prescribed at the rate of 10 mg / kg of body weight 1 time per day for 3 days (course dose - 30 mg / kg of body weight) or for 5 days: on the first day - 10 mg/kg of body weight, then 5-10 mg/kg of body weight 1 time per day for 4 days.
  Depending on the body weight of the child, the following dosage regimens are recommended:

  In the treatment of erythema migrans in children, the drug is prescribed 1 time per day for 5 days: 20 mg/kg of body weight on the first day and 10 mg/kg of body weight from 2 to 5 days.

  Suspension preparation.
  Single dose package. A small amount of boiled and cooled water is poured into a clean glass, then the contents of one package are poured out and mixed until a homogeneous suspension is obtained.
  After taking the glass, rinse with water, dry and store in a dry and clean place.
  Jar. In a jar containing 400 mg or 800 mg of azithromycin, 12 ml of boiled and chilled water or distilled water are added using a polymer compound dispenser; in a jar containing 1200 mg of azithromycin - 18 ml. The suspension is shaken before use.
  The suspension is dosed with a double-sided spoon: a large spoon contains 5 ml of suspension, a small one - 2.5 ml; or a spoon with two marks: the lower one corresponds to 2.5 ml of suspension and the upper one - 5 ml; or a polymer compound dispenser.
  After use, rinse the spoon and dispenser with water, dry and store in a dry and clean place.
  

• Amosin

  Amosin is intended for the treatment of bacterial infections caused by susceptible pathogens: infections of the respiratory tract (bronchitis, pneumonia) and upper respiratory tract (sinusitis, pharyngitis, tonsillitis, acute otitis media), genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis ), abdominal infections (peritonitis, cholangitis, cholecystitis), infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses), leptospirosis, listeriosis, Lyme disease (borreliosis), gastrointestinal tract (dysentery, salmonellosis, salmonellosis carriage), meningitis , endocarditis (prevention).
  

• Angiplant

  Solution Angiplant It is intended and recommended for use as a mouth and throat rinse in the treatment of inflammation of the throat and mouth.

• Tierfens

  Indications for the use of the drug Tierfens are:
  - treatment of acute and chronic inflammatory processes of the upper respiratory tract and respiratory tract (otitis media, sinusitis, rhinitis, nasopharyngitis, tracheitis, rhinotracheobronchitis, bronchitis);
  - as part of the complex therapy of bronchial asthma;
  - seasonal and year-round allergic rhinitis and other manifestations of allergies from the respiratory system and ENT organs;
  - respiratory phenomena with measles, whooping cough, influenza (cough, hoarseness, sore throat).
  

• Rofloxan

  A drug Rofloxan is used to treat bacterial infections caused by microorganisms sensitive to ofloxacin:
  - acute and chronic respiratory tract infections (bronchitis, pneumonia);
  - acute and chronic infections of ENT organs (especially infections caused by gram-negative bacteria, including Pseudomonas spp., Staphylococcus spp.);
  
  - infections of bones (osteomyelitis) and joints;
  - infectious and inflammatory diseases of the abdominal cavity (including infections of the gastrointestinal tract and biliary tract);
  - infections of the kidneys (pyelonephritis) and urinary tract (cystitis, urethritis);
  - infections of the pelvic organs (endometritis, salpingitis, oophoritis, cervicitis, parametritis, prostatitis) and genital organs (colpitis, orchitis, epididymitis);
  - gonorrhea;
  - chlamydia;
  - septicemia.
  

• Baktamed

  A drug Baktamed is intended for use in the treatment of bacterial infections of various localization caused by microorganisms sensitive to ampicillin / sulbactam:
  - respiratory infections (including pneumonia, lung abscess, chronic bronchitis, pleural empyema);
  - infections of ENT organs (including tonsillitis, sinusitis, otitis media);
  - infections of the urinary system and genital organs (including pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, endometritis);
  - infections of the skin and soft tissues (including erysipelas, impetigo, secondarily infected dermatitis);
  
  - infections of the gastrointestinal tract (including dysentery, salmonellosis, salmonellosis);
  - infections of the biliary tract (including cholecystitis, cholangitis);
  - bacterial septicemia;
  - meningitis;
  - peritonitis;
  - scarlet fever;
  - gonococcal infection.
  It is used for the prevention and treatment of postoperative complications.
  

• Flaprox

  A drug Flaprox is intended for use in the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug, including:
  - respiratory tract infections;
  - infections of the ear, throat and nose;
  - infections of the kidneys and urinary tract;
  - infections of the genital organs (gonorrhea, prostatitis, adnexitis, postpartum infections);
  - infections of the digestive system (including the mouth, teeth, jaws), gallbladder and biliary tract;
  - infections of the skin, mucous membranes and soft tissues;
  - infections of the musculoskeletal system;
  - sepsis;
  - peritonitis;
  - meningitis caused by gram-negative microflora;
  - tuberculosis (in combination therapy for drug-resistant tuberculosis);
  - prevention and treatment of infections in patients with reduced immunity (against the background of immunosuppressant therapy);
  - prevention of infections during surgical interventions.
  

• Tsiprobay

  Tsiprobay used in the treatment of uncomplicated and complicated infections caused by microorganisms sensitive to ciprofloxacin:
  adults
  - Respiratory tract infections. Ciprofloxacin is recommended for use in pneumonia caused by Klebsiella spp., Enterobacter spp., Proteus spp., Esherichia coli, Pseudomonas spp., Haemophilus spp., Branhamella spp., Legionella spp. and Staphylococcus spp.;
  - infections of the middle ear (otitis media), paranasal sinuses (sinusitis), especially if these infections are caused by gram-negative microorganisms, including Pseudomonas spp. or Staphylococcus spp.;
  - eye infections;
  - infections of the kidneys and / or urinary tract;
  - infections of the genital organs, including adnexitis, prostatitis;
  - gonorrhea;
  - infections of the abdominal cavity (for example, bacterial infections of the gastrointestinal tract or biliary tract, peritonitis);
  - skin and soft tissue infections;
  - infections of bones and joints;
  - sepsis;
  - infections or prevention of infections in immunosuppressed patients (for example, in patients taking immunosuppressants or with neutropenia);
  - selective decontamination of the intestine in patients with reduced immunity;
  
  Children
  - treatment of complications caused by Pseudomonas aeruginosa in children with pulmonary cystic fibrosis from 5 to 17 years;
  - prevention and treatment of pulmonary anthrax (infection with Bacillus anthracis).
  

• Erythromycin

  A drug Erythromycin intended for use in the treatment of bacterial infections caused by susceptible pathogens:
  - infections of ENT organs (laryngitis, pharyngitis, tonsillitis, sinusitis, external and otitis media);
  - infections of the lower respiratory tract (tracheitis, bronchitis, pneumonia);
  - infections of the skin and soft tissues (pustular skin diseases, including juvenile acne, infected wounds, bedsores, burns II-III stage, trophic ulcers);
  - infections of the biliary tract (cholecystitis);
  - urinary infections in pregnant women caused by Chlamydia trachomatis;
  - uncomplicated chlamydia in adults (with localization in the lower urinary tract and rectum) with intolerance or ineffectiveness of tetracyclines;
  - primary syphilis (in patients allergic to penicillins);
  - gonorrhea;
  - diphtheria (including bacterial carriage), whooping cough (including prevention), scarlet fever, trachoma, legionellosis (legionnaires' disease), erythrasma, listeriosis, amoebic dysentery;
  Prevention of exacerbations of streptococcal infection (tonsillitis, pharyngitis) in patients with rheumatism. Prevention of infective endocarditis during dental interventions and operations on ENT organs in patients with risk factors (heart defects, prosthetic valves, etc.). Erythromycin is a reserve antibiotic for allergies to penicillin and other antibiotics of the penicillin group, as well as to other beta-lactams.
  

• Cefosin

  Cefosin used in the treatment of infectious and inflammatory diseases caused by susceptible microorganisms:
  - infections of the central nervous system (meningitis),
  - infections of the respiratory tract and ENT organs,
  - urinary tract infections,
  - infections of bones and joints;
  - infections of the skin and soft tissues,
  - infections of the pelvic organs,
  - gonorrhea,
  - infected wounds and burns,
  - peritonitis,
  - sepsis,
  - abdominal infections,
  - endocarditis,
  - Lyme disease
  - salmonellosis,
  - infections on the background of immunodeficiency.
  Prevention of infections after surgical operations (including urological, obstetric and gynecological, in the gastrointestinal tract).
  

• Sumamed

  Sumamed is intended for use in the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
  - infections of the upper respiratory tract and ENT organs (pharyngitis / tonsillitis, sinusitis, otitis media);
  - infections of the lower respiratory tract (acute bronchitis, exacerbation of chronic bronchitis, pneumonia, including those caused by atypical pathogens);
  - infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, acne vulgaris of moderate severity (for tablets));
  - the initial stage of Lyme disease (borreliosis) - migratory erythema (erythema migrans);
  - urinary tract infections (urethritis, cervicitis) caused by Chlamydia trachomatis (for tablets and capsules).
  

• TARGOCYD

• AZIBIOT

• OSPEN

• Dorithricin

  Indications for the use of the drug Dorithricin are: infectious and inflammatory diseases of the oral cavity and pharynx, accompanied by pain syndrome: pharyngitis, laryngitis, the initial stage of tonsillitis; inflammation of the gums and oral mucosa (gingivitis, stomatitis).
  

• Azimed suspension

  A drug Azimed used to treat infections caused by microorganisms sensitive to azithromycin: infections of the upper respiratory tract (bacterial pharyngitis / tonsillitis, sinusitis, otitis media); respiratory tract infections (bacterial bronchitis, community-acquired pneumonia); skin and soft tissue infections: erythema migrans (the initial stage of Lyme disease), erysipelas, impetigo, secondary pyodermatoses.
  

• Cefix

  Indications for the use of the drug Cefix are:
  - infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
  - infections of the upper respiratory tract (including inflammation of the middle ear) and other infections of the upper respiratory tract (sinusitis, pharyngitis, tonsillitis of bacterial etiology) in case of known or suspected resistance of the pathogen to other commonly used antibiotics, or in case of risk of treatment failure;
  - infections of the lower respiratory tract (including acute bronchitis and exacerbation of chronic bronchitis);
  - urinary tract infections (including cystitis, cystourethritis, uncomplicated pyelonephritis).
  Clinically Cefix effective in the treatment of infections caused by common pathogens, including Streptococcus pneumoniae, Streptococcus pyogenes, E. coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (beta-lactamase positive and -negative), Moraxella (Branhamella) catarrhalis (beta-lactamase positive and -negative) ) and Enterobacter species. Shows a high degree of stability in the presence of beta-lactamases.
  Most strains of enterococci (Streptococcus faecalis, Group D Streptococci) and Staphylococci (in particular coagulase-positive, coagulase-negative and methicillin-resistant strains) are resistant to cefixime. Most strains of Pseudomonas, Bacteroides fragilis, Listeria monocytogenes and Clostridia are resistant to cefixime.
  

• TSIPROVIN

• Esparoxy

  A drug Esparoxy is intended for the treatment of mild to moderate infections caused by pathogens sensitive to the drug:
  - lower respiratory tract - acute bronchitis, pneumonia caused by Streptococcus pneumoniae, atypical pneumonia caused by Mycoplasma pneumoniae;
  - ENT organs - pharyngitis, tonsillitis, sinusitis, otitis media caused by group A beta-hemolytic streptococcus and Streptococcus pneumoniae;
  - skin and soft tissues - erysipelas, pyoderma caused by Staphylococcus aureus and group A beta-hemolytic streptococcus;
  - urinary tract - urethritis in men caused by Chlamydia trachomatis and Ureaplasma urealyticum.

• Klacid SR

  Indications for the use of the drug Klacid SR are: infectious and inflammatory diseases caused by microorganisms sensitive to clarithromycin:
  - infections of the lower respiratory tract (such as bronchitis, pneumonia);
  - infections of the upper respiratory tract and ENT organs (such as pharyngitis, sinusitis);
  - infections of the skin and soft tissues (such as folliculitis, inflammation of the subcutaneous tissue, erysipelas).
  

• Septrin

  Indications for the use of the drug Septrin are:
  - Respiratory tract infections: bronchitis (acute and chronic, relapse prevention), bronchiectasis, pleural empyema, lung abscess, pneumonia (treatment and prevention), incl. caused by Pneumocystis carinii in AIDS patients;
  - Urinary tract infections: urethritis, cystitis, pyelitis, pyelonephritis, prostatitis, epididymitis;
  - Urogenital infections: gonorrhea, chancre, venereal lymphogranuloma, inguinal granuloma;
  - Infections of the gastrointestinal tract: bacterial diarrhea, shigellosis, cholera (as part of combination therapy), typhoid fever and paratyphoid fever (including bacteriocarrier), cholecystitis, cholangitis, gastroenteritis caused by enterotoxic strains - E. coli;
  - Skin and soft tissue infections: acne, furunculosis, pyoderma, erysipelas, wound infections, soft tissue abscesses;
  - Infections of ENT organs: otitis media, sinusitis, laryngitis; surgical; septicemia, meningitis, osteomyelitis (acute and chronic), brain abscess, acute brucellosis, South American blastomycosis, malaria (Plasmodium falciparum), toxoplasmosis and whooping cough (as part of complex therapy).
  

• Berlocid

  Indications for the use of the drug Berlocid are: infections of the respiratory tract, ear, throat and nose, kidneys and genitourinary tract, gastrointestinal tract, brucellosis, nocardiosis, South American blastomycosis, pseudomycotic mycetoma, etc.
  

• Orybact

  Indications for the use of the drug Orybact are: respiratory tract infections: bronchitis (acute and chronic, prevention of relapses), bronchiectasis, pleural empyema, lung abscess, pneumonia (treatment and prevention), incl. caused by Pneumocystis carinii in AIDS patients; urinary tract: urethritis, cystitis, pyelitis, pyelonephritis, prostatitis, epididymitis; urogenital: gonorrhea, chancre, venereal lymphogranuloma, inguinal granuloma; Gastrointestinal tract: bacterial diarrhea, shigellosis, cholera (as part of combination therapy), typhoid fever and paratyphoid fever (including bacterial carriage), cholecystitis, cholangitis, gastroenteritis caused by enterotoxic strains of E. coli; skin and soft tissues: acne, furunculosis, pyoderma, erysipelas, wound infections, soft tissue abscesses; ENT organs: otitis media, sinusitis, laryngitis; surgical; septicemia, meningitis, osteomyelitis (acute and chronic), brain abscess, acute brucellosis, South American blastomycosis, malaria (Plasmodium falciparum), toxoplasmosis and whooping cough (as part of complex therapy).
  

• moflaxia

  A drug moflaxia It is used to treat infectious and inflammatory diseases caused by microorganisms sensitive to moxifloxacin:
  - acute sinusitis;
  
  - uncomplicated infections of the skin and subcutaneous structures;
  - community-acquired pneumonia, including community-acquired pneumonia, the causative agents of which are strains of microorganisms with multiple resistance to antibiotics *;
  - complicated infections of the skin and subcutaneous structures (including an infected diabetic foot);
  - complicated intra-abdominal infections, including polymicrobial infections, including intra-abdominal abscesses;
  - uncomplicated inflammatory diseases of the pelvic organs (including salpingitis and endometritis).
  * Multidrug-resistant Streptococcus pneumoniae includes penicillin-resistant strains and strains resistant to two or more antibiotics from groups such as penicillins (MIC ≥ 2 µg/mL), second-generation cephalosporins (cefuroxime), macrolides, tetracyclines and trimethoprim/sulfamethoxazole. Current official guidelines on the rules for the use of antibacterial agents should be taken into account.
  

• Abicef

  A drug Abicef used to treat infections caused by microorganisms susceptible to cefuroxime, or treatment of infections until the causative agent of an infectious disease is identified.
  Indications for the use of the drug Abicef are: infectious diseases of the respiratory tract: acute and chronic bronchitis, infected bronchiectasis, bacterial pneumonia, lung abscess, postoperative chest infections; infectious diseases of the throat, nose: sinusitis, tonsillitis, pharyngitis; infectious diseases of the urinary tract: acute and chronic pyelonephritis, cystitis, asymptomatic bacteriuria; infectious diseases of soft tissues cellulitis, erysipeloid, wound infections; infectious diseases of bones and joints: osteomyelitis, septic arthritis; infections in obstetrics and gynecology: infectious and inflammatory diseases of the pelvic organs; gonorrhea, especially in cases where penicillin is contraindicated; other infectious diseases, including septicemia and meningitis.
  Prevention of the occurrence of infectious complications after operations on the chest and in the abdominal cavity, on the pelvic organs, during vascular, cardiovascular and orthopedic operations.
  In most cases, monotherapy with Abicef PharmUnion is effective, but if necessary, it can be used in combination with aminoglycoside antibiotics or with metronidazole (orally, in suppositories or by injection).
  In the case of an existing or expected mixed aerobic and anaerobic infection (for example, peritonitis, aspiration pneumonia, abscess of the lungs, pelvic organs and brain) and a high probability of such an infection (for example, during operations on the large intestine and in gynecological surgery), it is acceptable to use the drug Abicef PharmUnion in combinations with metronidazole.
  In the treatment of pneumonia and exacerbation of chronic bronchitis, Abicef PharmUnion can be administered before oral administration of cefuroxime axetil, when necessary.
  

• Laripront

  A drug Laripront prescribed for the prevention or treatment of diseases of the oral cavity, larynx, pharynx: periodontitis; stomatitis; gingivitis; pharyngitis and laryngitis; chronic and acute tonsillitis; after and before operations in the oral cavity and pharynx.
  

• Azitrus Forte

  A drug Azitrus Forte used to treat infectious and inflammatory diseases caused by microorganisms sensitive to the drug;
  - Infections of the upper respiratory tract and ENT organs (tonsillitis, sinusitis, tonsillitis, pharyngitis, otitis media);
  - Scarlet fever;
  - Infections of the lower respiratory tract (bacterial, including those caused by atypical pathogens of pneumonia, exacerbation of chronic pneumonia, bronchitis);
  - Infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses);
  - Infections of the urinary tract (gonorrheal and non-gonorrheal urethritis, cervicitis);
  - Lyme disease (borreliosis), for the treatment of the initial stage (erythema migrans);
  - Diseases of the stomach and duodenum associated with Helicobacter pylori (as part of combination therapy).
  

• Doramycin

  A drug Doramycin used to treat infections caused by microorganisms sensitive to spiramycin:
  - confirmed tonsillopharyngitis caused by group A beta-hemolytic streptococci (as an alternative to treatment with beta-lactam antibiotics, especially if they cannot be used);
  - acute sinusitis (due to the microbiological characteristics of the infection, the use of macrolides is indicated when treatment with beta-lactam antibiotics is not possible);
  - superinfection in acute bronchitis;
  - exacerbation of chronic bronchitis;
  - community-acquired pneumonia in patients who do not have risk factors, severe clinical symptoms, clinical factors that indicate pneumococcal etiology of the disease. In case of suspicion of atypical pneumonia, the use of macrolides is appropriate, regardless of the severity of the disease and history;
  - skin infections with a benign course: impetigo, impetiginization, ecthyma, infectious dermo-hypodermatitis (especially beshikha), erythrasma;
  - infections of the oral cavity;
  - non-gonococcal genital infections;
  - chemoprevention of recurrences of acute rheumatic fever in patients allergic to beta-lactam antibiotics;
  - toxoplasmosis in pregnant women;
  - prevention of meningococcal meningitis in persons who are contraindicated in the use of rifampicin: in order to eradicate the microorganism (Neisseria meningitidis) in the nasopharynx; as prevention: to patients after treatment and before returning to social life; patients who have been in contact with a sputum-producing person within 10 days prior to his/her hospitalization.
  Spiramycin is not intended for the treatment of meningococcal meningitis. Official recommendations regarding the use of antibacterial agents should be followed. - sepsis;
  - inflammation of the membranes of the brain (bacterial meningitis, including in newborns);
  - infections of the abdominal organs (peritonitis, infections of the biliary tract, including cholangitis, gallbladder empyema and other infections of the gastrointestinal tract);
  - infections of bones and joints, infections of the maxillofacial region;
  - skin and soft tissue infections, infected wounds and burns;
  - prevention and treatment of infections in immunocompromised patients (including those with neutropenia and oncological diseases);
  - infections of the kidneys and urinary tract (uncomplicated and complicated, including pyelitis, acute and chronic pyelonephritis, cystitis, prostatitis, epididymitis);
  - respiratory tract infections (acute and chronic bronchitis, pneumonia, lung abscess, pleural empyema, bronchiectasis, etc.);
  - infections of ENT organs (mastoiditis, otitis media, etc.);
  - sexually transmitted infections (including gonorrhea);
  - before surgical interventions in order to prevent infections. - diseases of the respiratory tract (bronchitis, pneumonia, lung abscess, pleural empyema);
  - ENT organs (sinusitis, tonsillitis, pharyngitis, otitis media);
  - urinary tract (pyelonephritis, cystitis, asymptomatic bacteriuria);
  - skin and soft tissues (erysipelas, pyoderma, impetigo, furunculosis, phlegmon, wound infection, erysipeloid);
  - bones and joints (osteomyelitis, septic arthritis);
  - pelvic organs (endometritis, adnexitis, cervicitis);
  - sepsis;
  - meningitis;
  - gonorrhea;
  - Lyme disease (borreliosis);
  - prevention of infectious complications during operations on the organs of the chest, abdomen, pelvis, joints (including operations on the lungs, heart, esophagus, in vascular surgery with a high risk of infectious complications, during orthopedic operations).
  

"Ribomunil" is an immunomodulatory agent of bacterial origin. The drug is produced in two forms - these are tablets and granules intended for the preparation of a drinking solution.

pharmachologic effect

"Ribomunil" is a ribosomal-proteoglycan complex of microorganisms that most often cause infectious diseases affecting the ENT organs. "Ribomunil", analogues of the remedy - non-specific correctors). The composition contains ribosomes with antigens that are identical to the surface antigens of bacteria. Penetrating into the human body, they participate in the formation of specific antibodies to infectious agents, that is, they act as a vaccine.

Membrane proteoglycans have an effect on, as a result of which the phagocytic activity of macrophages and polynuclear leukocytes increases, and nonspecific resistance increases.

The action of the drug "Ribomunil" is due to the stimulation of the function of B- and T-lymphocytes, the production of serum and secretory immunoglobulins such as gamma and alpha interferon, interleukin-1, IgA.

"Ribomunil", analogues of the drug in complex therapy reduce the duration and increase the effectiveness of treatment. As a result, the need for taking bronchodilators and antibiotics is reduced, and the period of remission is increased.

Indications for use

For patients older than 6 months, the drug is prescribed for the treatment and prevention of infections in which relapses occur:

• diseases of the upper respiratory tract (tonsillitis, laryngitis, pharyngitis, sinusitis, rhinitis, otitis media);
• diseases that affect the respiratory tract (infection-dependent bronchial asthma, pneumonia, tracheitis, chronic bronchitis).

"Ribomunil", analogues of the drug are prescribed to patients from risk groups (children older than 6 months, elderly patients) for the prevention of recurrent diseases of an infectious nature (bronchial asthma, bronchitis and diseases of the upper respiratory tract in a chronic form). Prevention "Ribomunil" is necessary for those who often and for a long time get sick, live in regions with poor ecology. For the purpose of prevention, the immunostimulant is also used before the start of the autumn-winter season.

Use during pregnancy, lactation

When carrying a child and breastfeeding, the drug "Ribomunil" is taken with extreme caution. Its appointment is carried out taking into account the harm to the fetus and the intended benefits for the mother's body (it is known that many drugs, affecting the embryo, can disrupt the development of the child).

Contraindications to taking "Ribomunil"

Contraindications include autoimmune diseases and hypersensitivity to the components of the "Ribomunil" remedy. Instructions for use, reviews show that the drug is not suitable for patients under 6 months of age, and it is undesirable, as we have already mentioned, to use during pregnancy and lactation.

Application of the drug, dosing regimen

The drug is taken in the morning, before the first meal. A single dose is 0.75 mg (3 tablets of 0.25 mg, 1 tablet of 0.75 mg or 1 sachet of granules diluted in warm water).

For three weeks, the medication should be taken only on the first four days of the week, then for 2-5 months on the first four days of the month.

Children are mainly prescribed granules, since it is easier for them to take just this form of Ribomunil. Feedback from customers and doctors reflect the effectiveness of regular preventive courses lasting 3 months. For prevention purposes, it is recommended to conduct annual semi-annual courses or two preventive courses per year.

Side effects of "Ribomunil"

Both the bacterial immunostimulator itself and the analogues of "Ribomunil" rarely cause the development of side effects. In some cases, allergic reactions (angioneurotic edema, urticaria), fever, nausea, diarrhea, vomiting, transient hypersalivation (at the beginning of the drug) are noted. Cancellation of the drug requires only allergic reactions.

Almost all drugs can have side effects. Usually they appear as a result of taking the maximum dose, prolonged use of the drug, its use in conjunction with other medicines.

Interaction of "Ribomunil" with other drugs

"Ribomunil", analogues of the drug can be combined with other drugs (anti-inflammatory drugs, bronchodilators, antibiotics). However, in this case, it is worth consulting a doctor, since when several drugs are used together, there may be an increase (an overdose is possible) or a weakening (there will be no desired effect) of their action.

special instructions

The immunostimulator is prescribed with caution to HIV-infected patients and patients with periarteritis nodosa.

When using the remedy, you need to know that on the second or third day the body temperature may rise. Such a reaction of the body usually does not require discontinuation of treatment.

In addition to an increase in body temperature, there may be minor symptoms of diseases of the upper respiratory tract of infectious etiology.

Price, analogues, reviews

When choosing a means of "Ribomunil" analogues, price - information that is important to know. The approximate cost of "Ribomunil" in tablets of 0.75 mg (4 pcs.) Is 284-389 rubles. in Russia and UAH 96-137 in Ukraine.

Ribomunil tablets of 0.25 mg (12 pcs.) Can be purchased for 354-498 rubles. in Russia and for 148-203 UAH in Ukraine. The cost of "Ribomunil" in granules (4 packs of 0.75 mg each) is 304-380 rubles. and 101-134 UAH.

You can use other means instead of the drug "Ribomunil". Analogues and substitutes of the drug in Ukraine are of interest to many people, because they are much cheaper.

Currently, drug synonyms are not produced, but you can purchase an analogue containing another active substance. These tools have a similar effect.

Analogues of the drug include Immunal, Immunovit, Tamiflu, Vitamin C Acerola, Echinacea Immuno, Gorlospas (for children), Chistonos, Chistonos (for children), Apifarm (drops), "Naturcoxinum", "Agri" (preparation for children), "Aqualor Baby", "Aqualor Soft", "Respibron", "Aqualor Norm", "Aqualor Forte", "Aqualor Extra Forte", "Aqualor Throat ”, “Griposan”, “Nazaval Plus”, “Immunoflazid”, “Likopid”, “Immust”, “Agri”. Substitutes for "Ribomunil" should be purchased only after consulting a doctor.

"Respibron" in terms of the action that it has, is more similar to the described drug than all other analogues of "Ribomunil". The composition of this tool contains the following ribosomes:

• diplococcus causing pneumonia;
• Neisseria;
• klebsiella ozena;
• streptococcus A;
• streptococcus viridans;
• golden staphylococcus.

After the appointment of the drug "Ribomunil", analogues, price, instructions for use are carefully studied, if necessary, after consulting with a doctor, you can choose another remedy.

Parents who gave Ribomunil to their children are generally satisfied with the result, as their children get sick less often. The drug facilitates the course of infection, reduces the incidence. There are also negative reviews, which contain information that the effect obtained persisted only during the period of taking the drug and disappeared after its withdrawal.

Some doctors consider the drug harmful and useless, others report its safety and effectiveness. Often, expert reviews are based on a subjective attitude towards immunomodulators, and not on experience and observations. Doctors who leave negative reviews do not have modern knowledge about the functioning of the immune system and therefore do not understand how immunomodulating agents work in the human body.

The drug "Ribomunil", like other drugs, cannot act in the same way on the body of different people, so it is not always effective.