Calcium gluconate solution 10%. What is a solution. Preparations with the same active ingredient

20.05.2002

Latin name

Calcium gluconate solution for injections 10%

ATX

A12AA03 Calcium gluconate

Pharmacological group

Nosological classification (ICD-10)

  • D65-D69 Coagulation disorders, purpura and other hemorrhagic conditions
  • E83.5 Disorders of calcium metabolism
  • K71 Liver toxicity
  • K73 Chronic hepatitis, not elsewhere classified
  • O15 Eclampsia
  • R58 Bleeding, not elsewhere classified
  • T56 Toxic effects of metals
  • T78.4 Allergy, unspecified

Composition and form of release

1 ampoule with 10 ml solution for injection contains calcium gluconate 1 g; in a cardboard box 10 ampoules.

pharmachologic effect

Pharmacological action - anti-allergic, anti-inflammatory, hemostatic.

As a source of calcium ions, it is involved in the transmission of nerve impulses, the formation of bone tissue, the release of adrenaline by the adrenal glands, etc.

Pharmacodynamics

Improves muscle contraction, reduces capillary permeability; participates in the processes of blood coagulation, functional activity of the myocardium; has a moderate diuretic effect.

Indications

Hypocalcemia, allergic diseases, bleeding, increased vascular permeability, hepatitis (parenchymal, toxic), nephritis, eclampsia, poisoning with magnesium salts and oxalic acid.

Contraindications

Tendency to thrombosis, hypercalcemia, atherosclerosis.

Side effects

bradycardia; nausea, vomiting, diarrhea; locally - tissue irritation (with intramuscular injection - necrosis).

Dosage and administration

In / in, in / m, slowly (2-3 minutes). Ampoules with a solution are heated to body temperature before administration. Adults - 5-10 ml daily or 1 time in 2-3 days; children (not recommended in / m) - 1-5 ml every 2-3 days.

Precautionary measures

Storage conditions

In a place protected from light, at a temperature not lower than 25 ° C.

Calcium Gluconate, a widely used drug in medicine, is considered important in violation of calcium metabolism. To make up for the deficiency of the substance, use the medical form of release in the form of tablets or ampoules. It is useful to know how and when to use the drug in order to cope with various diseases without harm to the body.

Calcium gluconate - what is it

Before using the medication, it is useful to familiarize yourself with what calcium gluconate is. As a chemical substance, it is a white crystalline or granular powder, tasteless and odorless, with the chemical formula salt of gluconic acid. Its pharmacological action is reduced to replenish calcium deficiency. Also, the properties of the drug include anti-allergic, detoxifying and hemostatic effects. The drug is used for anti-inflammatory purposes, to increase permeability and reduce vascular fragility.

As part of 9% is calcium, which affects the corresponding metabolism in the body. Ions of the substance are needed for the transmission of impulses between nerve cells, contraction of skeletal and smooth muscles and myocardium. They are involved in the process of blood coagulation, formation and preservation of bone tissue. The drug compensates for the deficiency of ions, its action is milder and non-irritating than chloride.

Calcium tablets

The first form of release is calcium gluconate tablets, which are white flat-cylindrical in color and shape. 1 tablet contains 500 mg of the active substance, auxiliary in it is starch, talc and calcium stearate. Available in packs of 10 and 20 pieces, differ in price. They are prescribed for children, they have no taste, they are easily swallowed.

In ampoules

Injection solution of Calcium Gluconate is intended for intravenous or intramuscular administration. Outwardly, it is a colorless transparent liquid in 5 or 10 ml ampoules. It is used to normalize the work of the human body, restore the function of calcium metabolism. The drug affects the heart, the transmission of nerve impulses. Recommended for use by adults.

Injections of calcium gluconate

The drug can be administered by intravenous or intramuscular injections. In the first case, the procedure is carried out in a therapy room, the second option is suitable for home conditions. The indications for injections are a violation of the transmission of nerve impulses, the work of the myocardium and contraction of the heart muscles. Relieve injections from colds, allergies, internal bleeding.

Intravenously

For certain pathologies of the thyroid gland, calcium gluconate is prescribed intravenously. Indication for use is allergy, nephritis, liver intoxication. Injections into a vein are prescribed for vascular permeability, hepatitis, myoplegia and serve as a hemostatic agent. The doctor prescribes intravenous injections for poisoning, psoriasis, itching and eczema.

Relieves gluconate from skin diseases, boils, chronic colds and diabetes. Rheumatism and recovery after operations or long-term illnesses require the introduction of 10 ml of the drug into a vein, after which the blood is taken and given a subcutaneous injection or injection into the gluteal muscle. Children are shown only intravenous administration, because intramuscular injection can cause the formation of tissue necrosis.

Intramuscular

If pills are not available, then calcium gluconate is administered intramuscularly. For the procedure, the gluteal muscle is used as the softest, there is the least pain after the injection. The advantages of intramuscular administration include painlessness, the absence of bumps and bruises, rapid action and penetration into the blood. Contraindications are kidney failure, failure of the heart and lungs, excess calcium in the body.

Calcium gluconate - indications for use

Common factors for which Calcium Gluconate can be used are the following diseases and dysfunctions:

  • hypocalcemia;
  • increased permeability of cell membranes;
  • disturbances in the work of nerve impulses of muscle tissue;
  • hypoparathyroidism, osteoporosis, tetany;
  • disorders of vitamin D metabolism - rickets;
  • increased need for calcium - in pregnant women, during lactation, during postmenopause, for adolescents in the phase of active growth;
  • calcium deficiency in the diet;
  • bone fractures, chronic diarrhea, prolonged bed rest or treatment with diuretics, anti-epileptic drugs;
  • teething;
  • colds, runny nose, bronchitis;
  • poisoning with oxalic acid, magnesium salts, salts of fluoric acid - during chemical activity.

As an addition to complex therapy, tablets and injections are used:

  • with allergies and itchy dermatosis, atopic dermatitis;
  • for the treatment of febrile syndrome, urticaria, serum sickness;
  • to stop bleeding, including in gynecology;
  • to alleviate dystrophy, bronchial asthma, pulmonary tuberculosis, hepatitis, nephritis;
  • when removing toxins from the liver.

For allergies

Doctors have proven that calcium gluconate from allergies can help if the cause of the reaction is a lack of ions of the substance. The drug is prescribed for adults and children, combined with taking antihistamines. Tablets are taken before meals, washed down with water. The dose is prescribed individually, the course is from 1 to 2 weeks. In severe cases, intravenous injections are indicated.

With a cold

Dr. Komarovsky claims that calcium gluconate is necessary for children with a cold, because due to a deficiency of calcium ions, the child catches a cold. To increase the body's resistance, he is given pills or intravenous injections are prescribed. In addition to getting rid of a cold, indications for taking a substance by a child are rickets, thyroid diseases, allergies and skin diseases. According to reviews, it is useful to take the medicine during active growth.

Calcium gluconate - instructions for use

As with any drug, the instructions for using Calcium Gluconate contain a lot of useful information. According to the annotation, the drug is rapidly absorbed by the intestines, penetrating into the blood and taking an ionized and bound state. Ionized calcium remains the most physiologically active, it enters the bone tissue. It is excreted from the body with urine and feces.

You should carefully monitor the implementation of the dose prescribed by the doctor so that an overdose does not occur. It leads to hypercalcemia, for which calcitonin is the antidote. According to the instructions, the drug is not compatible with carbonates, salicylates and sulfates. Particular care should be taken in patients with hypercalciuria, reduced filtration work in the glomeruli. To prevent nephrourolithiasis, drinking plenty of water is recommended along with the intake.

How to drink in tablets

After prescribing the remedy, the question naturally arises of how to take Calcium Gluconate. Inexpensive tablets are taken before meals or 60-90 minutes after it, washed down with milk and chewed. Adults are prescribed up to 9 g per day, divided into 3 doses. Up to a year, the baby takes 0.5 g, up to 4 years - 1 g, then every 2 years the dose is increased by 0.5 g. Reception by children is carried out 2-3 times a day. During pregnancy and breastfeeding, women take no more than 9 g per day. Treatment lasts 10-30 days. Permissible daily dosage for elderly patients - 2 g.

How to inject

Injections of the drug are called hot injections, but not because they, like chloride, give a feeling of warmth or burning, but because of the introduction of a heated solution to body temperature. Over 14 years old, it is permissible to use 5-10 ml per day, administered at a time. The patient's condition affects the frequency of injections - every day, 2 days or every other day. Up to 14 years of age, you can enter a 10% solution up to 5 ml.

The drug is injected slowly - up to 3 minutes, sometimes the drip method is used. For intravenous injection, a clean syringe is used, cleaned of ethyl alcohol residues. Children are allowed to inject the drug only into a vein, because intramuscular use will lead to tissue necrosis, which, according to reviews, will take a long time to heal and leave discomfort on the body.

Side effects

Doctors note the following side effects of the drug:

  • irritation of the gastrointestinal tract, constipation when used internally;
  • when administered intramuscularly or intravenously, diarrhea, vomiting, nausea are possible;
  • bradycardia, burning of the mouth, fever;
  • quick injections cause a decrease in pressure, arrhythmia, cardiac arrest or fainting;
  • intramuscular injection can cause tissue necrosis;
  • an overdose is dangerous with an excess of ions.

Calcium gluconate is a medical drug aimed primarily at restoring the desired level of calcium in humans. It is actively used in medicine to normalize the physiological reactions of the human body, in which calcium ions take part.

The composition of the product

A solution of calcium gluconate for injection is available ready-made and is a clear, colorless and odorless liquid. The active component of the solution is calcium gluconate. In 10 ml of solution, its content is 10% (1g). Excipients in the injection solution are calcium saccharate and distilled water.

In pharmacies, you can most often find a 10% solution, in which there is 1 mg of gluconate per 10 ml of liquid.

The liquid is in a transparent glass ampoule. The package of such ampoules contains 10 pieces of 10 ml each.

Mechanism of action

Calcium ions, the deficiency of which the body reacts so sharply to, and which it really needs, take part in the conduction of nerve impulses. They make sure that the organs and systems in the body can work clearly and smoothly. After entering the body, calcium spreads through all its tissues and immediately begins its participation in metabolic processes.

Bone strength, normal blood clotting, increased production of adrenaline by the adrenal glands, reduced vascular permeability - all these processes are impossible without a normal calcium balance in the human body.

Important! The ions of this substance help the teeth and bones to remain strong and strong.

When to use

The drug is prescribed in such conditions of the body, when the level of calcium ions in the human blood decreases to a critical level.

Indications for the use of calcium gluconate in the form of injections:

  • therapy of allergic manifestations with the use of antihistamines.
  • in the treatment of inflammatory processes of any kind and various localization.
  • problems with the work of the kidneys, since the body very quickly loses calcium - it is excreted along with the urine.
  • hepatitis, which occurs with inflammation of the liver parenchyma, as well as in cases where the liver is exposed to any toxic effects.
  • violation of the thyroid gland (hypoparathyroidism) - due to such a disease, the concentration of calcium in the blood decreases sharply. The drug is not able to restore the lost functions of the glands, it only makes up for the lack of this element.
  • the drug is actively used as an auxiliary hemostatic agent for various bleeding - uterine, intestinal, nasal, pulmonary.
  • excessive permeability of cell walls.
  • childbearing, lactation, menopause, intensive growth in children and adolescents - all those periods when the body feels a high need for calcium.
  • rickets and other disorders of vitamin D metabolism.
  • fractures of bones of any complexity and increased fragility of bones.
  • appearance of teeth in children.
  • poisoning with certain types of salts and acids.
  • frequent rhinitis, colds, bronchitis.
  • osteoporosis.
  • a diet low in calcium.
  • conditions when calcium is intensively washed out of the body - prolonged diarrhea, treatment with drugs against epilepsy, bed rest for a long time, and others.

Contraindications

You can not use injections if you find the following signs:

  • individual intolerance to the main component.
  • an increase in the concentration of calcium in human blood up to 6 meq / l - this also applies to those cases where the increase was already due to calcium injections taken.
  • children under 15 years of age.
  • various kidney diseases.
  • excessively high blood clotting, in particular, a tendency to thrombosis.
  • pregnancy and lactation - it is impossible to use calcium injections.
  • excessive excretion of calcium in the urine.
  • atherosclerosis.

Rules for the use of injections

Intramuscular injections can be carried out at home, intravenous calcium gluconate should be administered only in the treatment room. The introduction of the drug is carried out very slowly - 2-3 minutes. Preparation of the drug for the procedure involves heating it up to +37 degrees.

Children under 14 years of age are prescribed a drug of 7 ml, depending on the disease, once a day or one injection once every 2-3 days.

Patients under 14 years of age: 1-5 ml once every 2-3 days, however, the introduction in this case should be only intravenous. Children should not be given intramuscular calcium injections - necrotic tissue necrosis is possible at the injection site.

On an individual basis, the doctor should develop a scheme for injections, select the dosage and determine the duration of the course of treatment. This is influenced by the patient's personal data: weight and height, gender, age group, disease and its severity.

Important! Self-administration of a calcium preparation in the form of injections is unacceptable. Only a doctor can assess the possible benefits and risks.

Intramuscularly, calcium gluconate is injected exclusively into the gluteal muscle - in it, pain from the injection will not be so noticeable. It will also avoid the formation of bumps and bruises, the drug will enter the bloodstream faster.

It is necessary to carry out a thorough antiseptic treatment of the surface for injection. Since necrosis or inflammation may develop at the injection site during administration, all safety measures must be taken to help avoid complications.

Injections of calcium gluconate are made with regular monitoring of electrolytes in the patient's blood.

With intramuscular injections, you can not take calcium tablets at the same time. Before starting treatment, it is imperative to make sure that there are no contraindications.

For pregnant women, calcium gluconate is prescribed in injections only in the most extreme cases - as a rule, tablets with a similar effect are shown during this period.

Description of adverse reactions

There are not too many side effects and undesirable consequences from the use of the drug in injections, but it is necessary to take into account the likelihood of their occurrence.

The instructions for use describe the following side effects:

  • as mentioned above, tissue necrosis at the injection site is the most common undesirable consequence. It occurs mainly due to a violation of the technique of administering the drug. To prevent it, each subsequent injection should be done in a different area. You can dilute the regimen of drug administration with 1-2 days of rest (with the regimen every other day). In this case, the method of temporarily canceling injections is very effective.
  • nausea, sometimes accompanied by vomiting, diarrhea or, conversely, constipation.
  • decrease or increase in heart rate. Such an effect is possible with excessively hasty administration of the drug.
  • redness of the skin at the injection site, their swelling and soreness.
  • there is a possibility of stones in the intestines - in the case of prolonged use of this drug and (or) the use of large doses of the drug.
  • kidney dysfunction, expressed in swelling of the legs, profuse and frequent urination.
  • the most severe consequences of taking it can be the development of anaphylactic shock and collapse (up to a fatal outcome - extremely rarely). Then you may need emergency help.

Important! If, nevertheless, any of the side effects has manifested itself, then any administration of calcium should be stopped.

Overdose

Cases of drug overdose are associated, as a rule, with its long period of use or excessively high dosage.

In cases of overdose, symptoms and conditions such as:

  • nausea, vomiting, constipation.
  • fatigue and excessive irritability.
  • pain in the abdomen.
  • muscle weakness.
  • increased urine production.
  • intense thirst and dry mouth.
  • increase in blood pressure.
  • the formation of kidney stones.

If the fact of an overdose is established, further use of the drug is immediately canceled. In especially difficult situations, the patient is prescribed intravenous injections of calcitonin. It is possible to use droppers with an antidote.

drug interaction

  1. The drug slows down the process of absorption of antibiotics of the tetracycline class, dosage forms of iron and fluorine.
  2. Enhances the toxicity of drugs to combat heart failure.
  3. Foods such as spinach, various cereals, bran, rhubarb reduce the absorption of calcium from the digestive system.

Ultrix vaccine: instructions for use Glucose during pregnancy: intravenous administration for the correction of physiological processes

Calcium gluconate solution for injections 10%

Active substance

›› Calcium gluconate (Calcium gluconate)

Latin name

Calcium gluconate solution for injections 10%

›› A12AA03 Calcium gluconate

Pharmacological group: Macro- and microelements

Nosological classification (ICD-10)

›› D65-D69 Coagulation disorders, purpura and other hemorrhagic conditions
›› E83.5 Disorders of calcium metabolism
›› K71 Liver toxicity
›› K73 Chronic hepatitis, not elsewhere classified
›› O15 Eclampsia
›› R58 Bleeding, not elsewhere classified
›› T56 Toxic effects of metals
›› T78.4 Allergy, unspecified

Composition and form of release

1 ampoule with 10 ml solution for injection contains calcium gluconate 1 g; in a cardboard box 10 ampoules.

pharmachologic effect

pharmachologic effect- anti-allergic, anti-inflammatory, hemostatic. As a source of calcium ions, it is involved in the transmission of nerve impulses, the formation of bone tissue, the release of adrenaline by the adrenal glands, etc.

Pharmacodynamics

Improves muscle contraction, reduces capillary permeability; participates in the processes of blood coagulation, functional activity of the myocardium; has a moderate diuretic effect.

Indications

Hypocalcemia, allergic diseases, bleeding, increased vascular permeability, hepatitis (parenchymal, toxic), nephritis, eclampsia, poisoning with magnesium salts and oxalic acid.

Contraindications

Tendency to thrombosis, hypercalcemia, atherosclerosis.

Side effects

bradycardia; nausea, vomiting, diarrhea; locally - tissue irritation (with intramuscular injection - necrosis).

Dosage and administration

In / in, in / m, slowly (2-3 minutes). Ampoules with a solution are heated to body temperature before administration. Adults - 5-10 ml daily or 1 time in 2-3 days; children (not recommended in / m) - 1-5 ml every 2-3 days.

Best before date

Storage conditions

In a place protected from light, at a temperature not lower than 25 ° C.

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Instructions for use

Description

A solution for intravenous and intramuscular administration of Calcium Gluconate-Vial compensates for the deficiency of calcium ions necessary for the transmission of nerve impulses, contraction of skeletal and smooth muscles, myocardial activity, bone tissue formation, blood clotting.

Active ingredients
Release form
Compound

Calcium gluconate monohydrate, lactic acid, calcium hydroxide, water for injection.

Pharmacological effect

When administered intravenously, it stimulates the sympathetic division of the autonomic nervous system, enhances the release of epinephrine by the adrenal glands, and has a moderate diuretic effect.

Pharmacokinetics

After parenteral administration, the drug with blood flow is evenly distributed in all tissues and organs. In plasma, about 45% is in complex with proteins. Passes through the placental barrier, passes into breast milk. It is excreted from the body mainly by the kidneys.

Indications

Diseases accompanied by: hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue. Hypoparathyroidism (latent tetany, osteoporosis), impaired vitamin D metabolism: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure. Increased need for calcium (pregnancy, lactation, a period of increased growth of the body), insufficient calcium in food, impaired metabolism (in the postmenopausal period). Increased excretion of calcium (prolonged bed rest, chronic diarrhea, secondary hypocalcemia against the background of long-term use of diuretics and antiepileptic drugs, glucocorticosteroids). Bleeding of various etiologies, allergic diseases (serum sickness, urticaria, febrile syndrome, itching, itchy dermatoses, reactions to drugs and food intake, angioedema), bronchial asthma, degenerative alimentary edema, pulmonary tuberculosis, rickets, osteomalacia, lead colic , eclampsia. Parenchymal hepatitis, toxic liver damage, nephritis, hyperkalemic form of paroxysmal myoplegia.

Contraindications

Hypersensitivity, hypercalcemia (calcium concentration should not exceed 12 mg or 6 mEq / l), severe hypercalciuria, nephrourolithiasis (calcium), sarcoidosis, concomitant use of cardiac glycosides (risk of arrhythmias).

Precautionary measures

With caution, the drug should be used for dehydration, electrolyte disorders (risk of hypercalcemia), diarrhea, calcium nephrourolithiasis (in history), slight hypercalciuria, moderate chronic renal failure, chronic circulatory failure, widespread atherosclerosis, hypercoagulation, childhood (for intramuscular injection - risk occurrence of necrosis).

Use during pregnancy and lactation

Allowed

Dosage and administration

Intramuscularly, intravenously slowly (within 2-3 minutes) or drip, adults - 5-10 ml of a 10% solution daily, every other day or 2 days later (depending on the nature of the disease and the patient's condition). Children - intravenously slowly (within 2-3 minutes) or drip, depending on age, from 1 to 5 ml of a 10% solution every 2-3 days. The solution is warmed to body temperature before administration. The syringe for the administration of calcium gluconate must not contain any ethanol residues (to avoid precipitation of calcium gluconate). It is not recommended to administer the drug intramuscularly to children due to the possible development of necrosis.

Side effects

With intramuscular and intravenous administration, nausea, vomiting, diarrhea, and bradycardia may occur. With intravenous administration, there may be a burning sensation in the oral cavity, a feeling of heat, with rapid intravenous administration - a decrease in blood pressure, arrhythmia, fainting, cardiac arrest. With intramuscular injection, necrosis may form at the injection site.

Overdose

Symptoms: hypercalcemia. Treatment: calcitonin, intravenously at the rate of 5-10 IU / kg b.w. / day (the drug is diluted in 500 ml of 0.9% sodium chloride solution, injected drip for 6 hours).

Interaction with other drugs

Pharmaceutically incompatible with ethanol, carbonates, salicylates, sulfates (forms insoluble or sparingly soluble calcium salts). Forms insoluble complexes with tetracycline antibiotics (reduces antibacterial effect). Reduces the effect of "slow" calcium channel blockers (intravenous administration of calcium gluconate before and after verapamil reduces its hypotensive effect). With simultaneous use with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine. During treatment with cardiac glycosides, parenteral use of calcium gluconate is not recommended (possibly increased cardiotoxic effect of glycosides). When combined with thiazide diuretics, it can increase hypercalcemia, reduce the effect of calcitonin in hypercalcemia, and reduce the bioavailability of phenytoin.

special instructions

Patients with mild hypercalciuria, a decrease in glomerular filtration rate, or a history of nephrourolithiasis should be prescribed with caution and under the control of calcium in the urine. Drinking plenty of fluids is recommended to reduce the risk of developing nephrourolithiasis.

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