Calcium gluconate from geographic language. Calcium gluconate tablets: use, side effects. When injections are given intramuscularly with calcium gluconate and how

Involved in metabolism and tissue construction. The amount of this mineral in the human body is about 2% of the total weight. A newborn child has approximately 30 g of calcium, with age this figure increases to 1000 - 1500 g.

Almost all calcium in the body is found in the form of compounds with phosphates and is found in the teeth and bones.

Only 1% of this microelement is observed in blood serum.

Calcium gluconate - what is it?

- calcium salt of gluconic acid. This is one of the most well-known Ca preparations that can be purchased at the pharmacy without a prescription. It is produced in the form of tablets of 250 and 500 mg or solution for injection. The cost of the drug is very democratic.

Calcium in the body is involved in the following processes:

• Regulates enzymatic activity.
• Participates in blood clotting and iron metabolism.
• Supports and takes part in muscle contraction.
• Normalizes the work of the endocrine system.
• Improves the transmission of nerve impulses.

How to understand that there is not enough calcium in the body?

If there is not enough calcium in the body, a person has the following symptoms:

• Decreased performance. He becomes lethargic, weak, gets tired quickly.
• Nails become soft and brittle.
• The scalp sweats a lot, and the hair splits.
• The skin becomes dry and often flaky.
• and numbness of the fingers.
• Meteorological dependence appears, before the change of weather there is an ache in the bones, pain in the arms and legs.
• Blood clotting is disturbed, bleeding often occurs.
• Cardiac activity is disturbed, shortness of breath and tachycardia appear.
• Bones become brittle and brittle, even a minor injury can lead to a crack or fracture.
• If calcium levels are low for a long time, subcapsular cataracts may occur.
• In children, a lack of calcium can cause changes in the functioning of the nervous system. The child becomes easily excitable, does not sleep well, in severe cases, he may experience convulsions. Also, it can disrupt the formation of teeth.

Video about the absorption of calcium in the body

How is calcium level diagnosed in medicine (biochemistry)?

In order to determine the level of calcium in the body, it is necessary to do a biochemical analysis. For this, blood is taken from a vein. Taking occurs in the morning, on an empty stomach, after an eight-hour fast. Do not drink alcohol before taking the test.

The microelement in the blood serum is contained in the form of ionized calcium, compounds (lactate, phosphate, bicarbonate) and calcium associated with proteins. Normally, its total content is from 2.15 to 2.5 mmol / liter.

What is calcium and what kind does the body need?

• calcium gluconate is the calcium salt of gluconic acid. Contains little elemental calcium (90 mg per 1 g of salt). One of the most famous drugs. It is produced in the form of tablets and solution for injection. Calcium gluconate preparations are used to strengthen bone tissue and as an aid in allergic diseases and bleeding. Calcium gluconate is poorly absorbed by the body and contributes to the formation.
• calcium lactate- calcium salt of lactic acid. 1 substance contains 130 mg of elemental calcium. The tool is practically no different from calcium gluconate.
• - calcium carbonate. It contains the largest amount of elemental calcium (400 mg per 1 g of salt). The drug is available in the form of tablets and capsules. Used to treat hypocalcemia, osteoporosis and bleeding disorders.
• calcium citrate- salt of calcium and citric acid. It ranks second in the content of elemental calcium (200 mg per 1 g). This is the optimal dosage form, which makes it possible to replenish the reserves of the microelement in the body. At the same time, it has a low ability to form kidney stones.
• calcium chloride- calcium salt of hydrochloric acid. Contains 270 mg of elemental calcium per 1 g. The drug is produced as a solution for injection and for oral administration. It is administered intravenously, with a strong sensation of heat. When ingested, it irritates the gastric mucosa. It is prescribed for allergic reactions and in order to improve blood clotting.
• Calcium glycerophosphate- glycerol-phosphorus-calcium salt (191 mg of elemental calcium per 1 g). It is taken to compensate for the lack of calcium in the body, to treat dystrophy and improve the body's resistance to infectious diseases.

When should adults drink calcium gluconate?

Calcium gluconate should be consumed in diseases that lower the level of this trace element in the blood. It is also used during pregnancy and lactation or with insufficient Ca content in food. They take calcium gluconate tablets in the complex treatment of various diseases (allergies, asthma, dermatosis, nephritis).

The average daily dose of calcium gluconate for adults is 1-3 g. If one tablet contains 500 mg of the active substance, then up to 6 tablets should be taken during the day.

When should children drink calcium gluconate?

Calcium gluconate is prescribed for children with increased excitability, insomnia, and convulsive syndrome. It is also used during a period of intensive growth, or for diseases such as or rickets.

• Children under 1 year of age are prescribed 500 mg of calcium per day (1 tablet).
• If the child is 1-4 years old, 1 g of calcium (2 tablets) should be given.
• Children from 5 to 9 years old are prescribed 1.5 - 2 g (3 - 4 tablets).
• Children from 10 to 14 years old 2 - 3 g (4 - 6 tablets).

What preparations contain calcium gluconate?

Medicines containing calcium gluconate include:

• Calcium gluconate in the form of tablets of 500 mg and a solution of 10%.
• Calcium gluconate with a fruity taste. It is produced in the form of tablets containing 500 mg of the active substance.
• Pagluferal. The composition of this drug, in addition to calcium gluconate, includes bromisoval, caffeine, papaverine and phenobarbital. Take a remedy for epilepsy.
• Flurex. It contains dephingidramine, paracetamol and calcium gluconate. The drug is taken to relieve symptoms of acute respiratory diseases.

When are intramuscular injections of calcium gluconate given and how?

Calcium gluconate in the form of injections is prescribed in the following cases:

• Loss of calcium in the body.
• Allergy.
• Dermatological diseases (urticaria, psoriasis, eczema).
• To reduce vascular permeability.
• As an antidote for poisoning with acids or magnesium salts.

For children, the drug is administered exclusively intravenously by stream or drip, as intramuscular injections can cause tissue necrosis. During the injection, there is a feeling of warmth.

For adults, calcium gluconate is administered intravenously or intramuscularly, depending on the disease. Injections are given daily or every other day. The ampoule is preheated to body temperature. Both children and adults should administer the drug slowly, over 3 minutes.

What foods can replace calcium gluconate?

If the level of calcium in the body is increased as a result of malnutrition, then it can be replenished without the use of drugs. To do this, the following foods containing Ca are introduced into the diet:

• Milk and kefir 3.2% - 120 mg of calcium per 100 g.
• Cottage cheese - 160 mg per 100 g.
• Hard cheese - 1 g per 100 g.
• Legumes - 150 mg per 100 g.
• Milk chocolate - 150 mg per 100 g.
• Fish - 50 mg per 100 g.

With rickets, osteoporosis, thyroid dysfunction, pancreatitis or liver failure, additional calcium intake in the form of drugs is necessary.

Doctor Komarovsky's opinion about calcium gluconate for children

Dr. Komarovsky believes that with a normal level of Ca in the blood and proper nutrition, calcium gluconate should be taken in accordance with the instructions. But if the level of this microelement is lowered, then the average daily dose of the drug in children under one year old should be 1.5 g.

In the future, from 1 year to 4 years, it rises to 3 g, and from 5 years to 6 g. Adults in this case should take at least 15 g of calcium gluconate per day.

Video - Injections of calcium gluconate Dr. Komarovsky

Eggshell myth - is it true that it replaces calcium gluconate?

Almost everyone has heard about the eggshell, which is used as a source of calcium. Indeed, it is 90% composed of this element. In order to prepare a medicine, traditional medicine recommends boiling an egg, grinding the shells cleared of films, and mixing it with lemon juice. Thus, in the course of a chemical reaction, calcium citrate is formed.

But as a result of research, scientists have found that such calcium is poorly absorbed, so it cannot fully compensate for the deficiency of the microelement in the body. The remedy should be taken only for preventive purposes.

Calcium gluconate for allergies, when to use and what is the connection?

Calcium plays an important role in metabolic processes. Its deficiency in the body can cause allergic reactions. As a result of the lack of this trace element, allergens freely enter the bloodstream and spread throughout the body.

With the additional introduction of calcium into the body, the walls of the vessels are strengthened, respectively, the number of allergens in the blood decreases, and the body's immune response in the form of an allergic reaction does not manifest itself.

First of all, calcium gluconate for allergies is prescribed to children, because in the process of growth, their body spends a large amount of this element.

What to eat for better absorption of calcium gluconate?

The absorption of calcium is a rather complex process that depends on many factors. First of all, you need to have enough vitamins D and K in the body.

In order for calcium to be actively absorbed into the diet, you need to introduce the following foods:

• Various types of cabbage.
• Spinach.
• Turnip.
• Nuts.
• Lentils.
• Figs.
• Petrushka.
• Celery.
• Strawberries.
• Sweet cherry.

What can lead to an overdose of gluconate and how to detect it?

As a result of uncontrolled intake of drugs containing calcium or hypercalcemia occurs. In this case, its level in the blood exceeds 2.6 mmol / liter. It can also appear due to the appearance of neoplasms in the thyroid gland, cancer or impaired kidney function.

Symptoms of hypercalcemia:

• From the gastrointestinal tract: lack of appetite, frequent constipation, weight loss, exacerbation of peptic ulcer, abdominal pain.
• From the nervous system: deterioration of concentration, drowsiness, fatigue, weakness, impaired reflexes, muscle weakness. In severe cases, confusion and hallucinations, delusions, lethargy and stupor are possible.
• From the musculoskeletal system: muscle weakness, bone pain.
• From the genitourinary system: unquenchable thirst, dehydration, slowing down the formation of urine,.
• From the side of the cardiovascular system: hypertension, arrhythmia.

Despite the benefits of calcium gluconate, you should not prescribe it yourself, you must first consult a doctor.

Video about how much calcium you can take so as not to harm your health

One tablet contains: active ingredient- calcium gluconate - 500 mg, Excipients- potato starch, talc, magnesium stearate, anhydrous colloidal silicon dioxide.

Pharmacotherapeutic group

Calcium preparations.
ATX code: A12AA03.

Pharmacological properties

Pharmacodynamics
Normalizes calcium metabolism in the body.
Pharmacokinetics
About one third of the calcium consumed is absorbed in the gastrointestinal tract, mainly in the small intestine. 99% of calcium in the body is concentrated in the solid structures of bones and teeth, the rest -1% - in the intra- and extracellular fluid. Calcium is found in the blood in both free (ionized) and bound forms. Calcium is excreted in faeces, urine and sweat.

Indications for use

– prevention and treatment of calcium deficiency;
– replenishment of calcium requirements as an adjunct to specific osteoporosis therapy in patients at risk of calcium deficiency.

Contraindications

- hypersensitivity to active substances or to any of the excipients;
- severe renal failure;
– active form of tuberculosis;
- hypercalcemia or hypercalciuria;
- nephrolithiasis.

Dosage and administration

Assign inside, before eating. The tablet must be crushed or chewed before swallowing.
Use in adults:
-with calcium deficiency: one tablet 1-3 times a day;
- adjunctive therapy for osteoporosis: one tablet 1-3 times a day.
Application in children:
- with calcium deficiency: one tablet 1-2 times a day.
Use in persons with impaired renal function. Use in patients with severe renal impairment is not recommended. No special dose adjustment or frequency of use is required in patients with moderate to moderate renal impairment.
Use in persons with impaired liver function. No special dose adjustment or frequency of use is required in patients with impaired liver function.
Use in the elderly. The dose is the same as for adults. A possible decrease in creatinine clearance should be taken into account.
The duration of use for the prevention and treatment of calcium deficiency is determined by the doctor and averages from ten days to one and a half months.

Side effect

Adverse reactions are listed according to the classification of undesirable adverse reactions in accordance with the damage to organs and organ systems and the frequency of development.
The frequency is defined as: infrequently(≥ 1/1000, ˂1/100), rarely(≥ 1/10000, ˂ 1/1000), or very rarely(˂ 1/10000).
Metabolic and nutritional disorders
Infrequently: hypercalcemia and hypercalciuria.
Very rare: milk-alkaline syndrome (usually only in case of overdose).
From the gastrointestinal tract
Rarely: mild gastrointestinal disorders: constipation, diarrhea.
Very rare: dyspepsia.
Skin and subcutaneous tissue disorders
Very rare: itching, rash, urticaria.
From the side of the cardiovascular system
Cardiac arrhythmias and bradycardia are possible.

Precautionary measures

Calcium supplements should be used with caution in patients with heart disease or sarcoidosis. Careful monitoring of the amount of calcium in the blood, calcium excretion in the urine is necessary when prescribing high doses of the drug, especially in children.
Treatment should be stopped if the blood calcium level exceeds 2.625–2.75 mmol/l or if urinary calcium excretion exceeds 5 mg/kg. Patients with mild hypercalciuria, a decrease in glomerular filtration rate, or a history of nephrolithiasis should be prescribed with caution and under the control of calcium in the urine. Caution should be exercised in patients who simultaneously use other vitamin-mineral complexes, due to the possible presence of calcium in their composition, which can lead to its overdose.

Use during pregnancy and lactation

Pregnant women who take calcium supplements with vitamin D are more likely to develop hypercalcemia. In the recommended doses, taking calcium supplements does not cause any negative consequences for the fetus; it is also safe to use when breastfeeding.

Influence on the ability to drive cars and mechanisms

Does not affect.

Overdose

Intentional overdose is unlikely.
Symptoms: anorexia, muscle weakness, nausea, vomiting, headache, intense thirst, dizziness, increased blood urea. Calcium can be deposited in the kidneys, arterial walls.
Milk Alkaline Syndrome may occur in patients taking orally large amounts of calcium and absorbable alkaline foods. Symptoms: frequent urination, prolonged headache, loss of appetite, nausea, vomiting, weakness, hypercalcemia, renal failure.
Treatment: minimizing calcium intake, abolishing drugs that promote hypercalcemia (thiazides, vitamin D), correction of dehydration and electrolyte imbalance, if necessary, the appointment of loop diuretics (furosemide). In severe cases, a significant amount of calcium can be removed by peritoneal dialysis. Patients with symptoms of overdose should avoid exposure to direct sunlight. In the treatment of calcium overdose, special attention should be paid to patients with impaired renal function.

Attention! The information is provided for informational purposes only. This manual should not be used as a guide to self-medication. The need for appointment, methods and doses of the drug are determined solely by the attending physician.

general characteristics

international and chemical names: Calcium gluconate;
calcium salt of gluconic acid;

main physical and chemical properties: white tablets;

compound: one tablet contains calcium gluconate 0.5 g;

Excipients: potato starch, calcium stearate, aerosil.

Release form. Tablets.

Pharmacotherapeutic group

Calcium preparations. ATC code A12AA03.

Pharmacological properties

Pharmacodynamics: Calcium ions are involved in the transmission of nerve impulses, the contraction of smooth and striated muscles, the functioning myocardium (Myocardium- the muscular tissue of the heart, which makes up the bulk of its mass. Rhythmic coordinated contractions of the myocardium of the ventricles and atria are carried out by the conduction system of the heart), blood coagulation, they are necessary for the normal formation of bone tissue, the functioning of other systems and organs. The concentration of calcium ions in the blood decreases in many pathological processes; severe hypocalcemia leads to tetany (Tetany- a disease characterized by hypofunction of the parathyroid glands). Calcium gluconate-Darnitsa, in addition to eliminating hypocalcemia, reduces vascular permeability, has an anti-allergic, anti-inflammatory, hemostatic effect.

Pharmacokinetics: After oral administration, the drug is rapidly absorbed in the intestine and penetrates into the blood, where it is in an ionized and bound state. Ionized calcium has physiological activity, its depot is bone tissue. It is excreted from the body with urine, but to a large extent - with feces.

Indications for use

Calcium gluconate-Darnitsa is used for insufficient parathyroid function glands (glands- organs that produce and secrete specific substances that are involved in various physiological functions and biochemical processes of the body. Endocrine glands secrete their metabolic products - hormones directly into the blood or lymph. External secretion glands - on the surface of the body, mucous membranes or in the external environment (sweat, salivary, mammary glands)), increased excretion of calcium from the body (in particular, with prolonged immobilization of the patient), for the prevention and elimination of calcium deficiency during the period of intensive growth and development in children and adolescents, during pregnancy and lactation, with postmenopausal osteoporosis (Osteoporosis- rarefaction or dystrophy of bone tissue with a restructuring of its structure, accompanied by a decrease in the number of bone crossbars per unit volume of the bone, thinning, curvature and complete resorption of some of these elements of various etiologies), systemic corticosteroid therapy (Therapy- 1. The field of medicine that studies internal diseases, one of the oldest and main medical specialties. 2. Part of a word or phrase used to indicate a type of treatment (oxygen therapy\; hemotherapy - treatment with blood products)), deficit vitamin D (Vitamin D- a group of steroidal vitamins involved in the regulation of calcium and phosphorus metabolism in the body, the deficiency of which leads to the development of rickets), rickets, osteomalacia, bone fractures; as an adjunct in allergic diseases, including allergic complications associated with taking medications, to reduce vascular permeability in pathological processes of various origins, with parenchymal hepatitis, toxic (Toxic- poisonous, harmful to the body) liver damage, nephritis, eclampsia, hyperkalemic form of paroxysmal myoplegia (Myoplegia- a hereditary disease of the nervous system, which is characterized by the development of attacks of flaccid paralysis of the skeletal muscles, plunging the patient into temporary immobility. During an attack, intracellular potassium metabolism in skeletal muscles and myoneural synapses is disturbed), for skin diseases.

Dosage and administration

Calcium gluconate-Darnitsa is administered orally before meals. Adults are prescribed at a dose of 1-3 g (2-6 tablets) 2-3 times a day. Children aged 3 to 4 years - 1 g each, from 5 to 6 years old - 1-1.5 g each, from 7 to 9 years old - 1.5-2 g each, from 10 to 14 years old - 2 3 g. Take 2-3 times a day. The daily dose of the drug for the elderly should not exceed 2 g.

Side effect

Possible nausea, vomiting, diarrhea (Diarrhea- rapid release of liquid stools associated with the accelerated passage of intestinal contents due to increased peristalsis, impaired absorption of water in the large intestine and the release of a significant amount of inflammatory secretion by the intestinal wall), pain in the epigastric region, bradycardia (Bradycardia- a decrease in the number of heartbeats to 60 beats per minute or less (absolute bradycardia) or a lag in the increase in heart rate from an increase in body temperature).
In cases of side effects, stop taking the drug and consult a doctor.

Contraindications

Tendency to thrombosis, hypercalcemia, severe hypercalciuria, severe renal failure, atherosclerosis (Atherosclerosis- a systemic disease characterized by damage to the arteries with the formation of lipid (mainly cholesterol) deposits in the inner lining of the vessels, which leads to a narrowing of the lumen of the vessel up to complete blockage), hypersensitivity to the drug.

Overdose

In case of an overdose, hypercalcemia may develop. In that case, as antidote (Antidotes- drugs used to treat poisoning in order to neutralize the poison and eliminate the pathological disorders caused by it) use calcitonin.

Application features

Patients with mild hypercalciuria, mild renal impairment, or urolithiasis (Urolithiasis disease-formation of kidney stones in history (Anamnesis- a set of information about the development of the disease, living conditions, previous diseases, etc., collected for the purpose of using it for diagnosis, prognosis, treatment, prevention) the drug should be administered with caution and regularly monitor the level excretions (Excretion(later lat. excretio) - the same as excretion) urine calcium. Patients with a tendency to form stones in the urine are advised to increase the amount of fluid consumed.

Interaction with other drugs

Calcium gluconate-Darnitsa eliminates the inhibition of neuromuscular transmission after application antibiotics (Antibiotics- substances that have the ability to kill microbes (or prevent their growth). Used as drugs that suppress bacteria, microscopic fungi, some viruses and protozoa, there are also antitumor antibiotics) aminoglycosides. The drug when used together with thiazide diuretics (Diuretics- medicinal substances that increase the excretion of urine by the kidneys and thereby contribute to the removal of excess water and sodium chloride from the body) leads to the development of hypercalcemia.
When used simultaneously with fenigidin, calcium preparations reduce its effect.
Calcium supplements increase toxicity (Toxicity- the ability of some chemical compounds and substances of biological nature to have a harmful effect on the human body, animals and plants) quinidine. Do not prescribe the drug simultaneously with other calcium preparations, cardiac glucosides, antibiotics of the tetracycline group, phenytoin. Vitamin (vitamins- organic substances formed in the body with the help of intestinal microflora or supplied with food, usually vegetable. Necessary for normal metabolism and life) D increases the absorption of calcium.

Product General Information

Terms and conditions of storage. Store in a dry place out of the reach of children. Shelf life - 5 years.

Holiday conditions. Without recipe.

Package. 10 tablets in a blister pack.

Manufacturer.CJSC "Pharmaceutical firm "Darnitsa".

Location. 02093, Ukraine, Kyiv, st. Borispolskaya, 13.

Website. www.darnitsa.ua

This material is presented in free form on the basis of the official instructions for the medical use of the drug.

calcium gluconate(English) calcium gluconate, lat. calcii gluconas) - calcium salt of gluconic acid, used in medicine for calcium deficiency in the body.

Calcium gluconate is a chemical

In pharmaceuticals, it is often used in the form of calcium gluconate monohydrate, when a water molecule is attached to a calcium gluconate molecule: C 12 H 22 CaO 14 H 2 O or the “text” version: (HOCH 2 (CHOH) 4 COO) 2 Ca . H2O.

Calcium gluconate - international non-proprietary name of the drug

• "BUT. Drugs affecting the digestive tract and metabolism ", subsection "A12 Mineral supplements", group "A12AA Calcium preparations" and has the code A12AA03


• "D. Preparations for the treatment of skin diseases", subsection "D11 Other preparations for the treatment of skin diseases", group "D11AX Other preparations for the treatment of skin diseases" and has the code D11AX03

Indications for the use of calcium gluconate

• diseases accompanied by calcium deficiency, increased permeability of cell membranes, impaired conduction of nerve impulses in muscle tissue
• hypoparathyroidism (latent tetany, osteoporosis)
• disorders of vitamin D metabolism: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure.
• conditions that increase the need for calcium: pregnancy, breastfeeding, increased body growth
• insufficient calcium content in food, calcium metabolism disorders (in the postmenopausal period)
• acute inflammatory processes in the oral cavity, accompanied by edema, postoperative period (to reduce edema), remineralizing therapy for the prevention and treatment of caries and non-carious tooth lesions
• increased excretion of calcium with prolonged bed rest, chronic diarrhea, secondary hypocalcemia with prolonged use of diuretics and antiepileptic drugs, glucocorticosteroids
• poisoning with magnesium salts, oxalic and fluoric acids and their soluble salts (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed)
• hypercalcemic form of paroxysmal myoplegia

How to take calcium gluconate

Side effects of calcium gluconate treatment

• constipation (when taken orally)
• irritation of the mucous membrane of the gastrointestinal tract (when taken orally)
• nausea, vomiting, diarrhea, bradycardia (when administered intramuscularly or intravenously)
• heat or burning in the mouth and throughout the body (when administered intravenously)
• hypercalcemia

Features of calcium gluconate therapy in pregnant and lactating women

There are no scientific data on the penetration of calcium into milk from the body of a nursing mother. Calcium is considered a normal nutritional component of human milk. The calcium content in breast milk averages 300 mg per litre. The recommended daily intake of calcium for a woman during lactation is 1200 mg. One liter of cow's milk contains about 1200 mg of calcium.

Pregnant or lactating women who do not consume milk or dairy products may need supplemental calcium.

Medicinal mono- and multicomponent preparations containing calcium gluconate

Calcium gluconate is also included in multicomponent preparations:
and others. On the site in the Literature section there is a subsection "Nutraceuticals", containing articles that, among other things, affect the use of mineral supplements.

Calcium gluconate (solution for intravenous and intramuscular injection; solution for injection; tablets) is included in the List of Vital and Essential Medicines.

Calcium gluconate has contraindications, side effects and application features, before use, consultation with a specialist is necessary.

Calcium challenge test to confirm the presence of a gastrinoma

Calcium gluconate - food supplement

• infant formula milk
• coffee drinks
• bread and bakery products
• flour confectionery

In agriculture, calcium gluconate is used in the preparation of animal feed.

pharmachologic effect

The Ca2+ preparation compensates for the deficiency of Ca2+, which is necessary for the process of transmission of nerve impulses, contraction of skeletal and smooth muscles, myocardial activity, bone tissue formation, blood coagulation.

Indications

• Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including blood vessels), impaired conduction of nerve impulses in muscle tissue.
• Hypoparathyroidism (latent tetany, osteoporosis), vitamin D metabolism disorders: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure.
• Increased need for Ca2+ (pregnancy, lactation, period of increased body growth), insufficient Ca2+ in food, impaired metabolism (in the postmenopausal period).
• Increased excretion of Ca2 + (prolonged bed rest, chronic diarrhea, secondary hypocalcemia against the background of long-term use of diuretics and antiepileptic drugs, corticosteroids).
• Bleeding of various etiologies; allergic diseases (serum sickness), urticaria, febrile syndrome, itching, itchy dermatoses, reactions to the administration of drugs and food intake, angioedema); bronchial asthma, dystrophic nutritional edema, pulmonary tuberculosis, lead colic; eclampsia.
• Poisoning with Mg2+ salts, oxalic and fluoric acids and their soluble salts (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed).
• Parenchymal hepatitis, toxic liver damage, nephritis, hyperkalemic form of paroxysmal myoplegia.

Contraindications

• Hypersensitivity, hypercalcemia (Ca2 + concentration should not exceed 12 mg% = 6 mEq / l), severe hypercalciuria, nephrourolithiasis (calcium), sarcoidosis, simultaneous intake of cardiac glycosides (risk of arrhythmias). With caution.
• Dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolithiasis (history), slight hypercalciuria, moderate chronic renal failure, chronic heart failure, widespread atherosclerosis, hypercoagulation, for i / m administration - children's age (risk of necrosis).

Side effects

• When taken orally - constipation, irritation of the gastrointestinal mucosa.
• With the / m and / in the introduction - nausea, vomiting, diarrhea, bradycardia.
• With a / in the introduction - a burning sensation in the oral cavity, a feeling of heat, with a rapid / in the introduction - a decrease in blood pressure, arrhythmia, fainting, cardiac arrest.
• With the / m introduction - necrosis at the injection site.

Overdose

Hypercalcemia, to eliminate it, 5-10 IU / kg / day of calcitonin is administered (diluted in 0.5 l of 0.9% NaCl solution). The duration of the introduction is 6 hours.

Dosage and administration

• Inside, in / in, in / m.
• Inside, before meals or 1-1.5 hours after ingestion, adults - 1-3 g 2-3 times a day. Children under 1 year - 0.5 g; 2-4 years - 1 g; 5-6 years - 1-1.5 g; 7-9 years - 1.5-2 g; 10-14 years old - 2-3 g; multiplicity of reception - 2-3 times a day. In / m, in / in slowly (within 2-3 minutes) or drip, adults - 5-10 ml of a 10% solution daily, every other day or after 2 days (depending on the nature of the disease and the patient's condition). Children - in / in slowly (within 2-3 minutes) or drip, depending on age, from 1 to 5 ml of a 10% solution every 2-3 days. The solution is warmed to body temperature before administration. The syringe for the introduction of calcium gluconate should not contain ethanol residues (to avoid precipitation of calcium gluconate).

special instructions

Patients with mild hypercalciuria, a decrease in glomerular filtration rate, or a history of nephrourolithiasis should be administered under the control of urinary Ca2+ concentration. Drinking plenty of fluids is recommended to reduce the risk of developing nephrourolithiasis.

Interaction

• Pharmaceutically incompatible with carbonates, salicylates, sulfates (forms insoluble or sparingly soluble Ca2+ salts).
• Forms insoluble complexes with tetracycline antibiotics (reduces antibacterial effect).
• Reduces the effect of BMCC (in / in the introduction of calcium gluconate before or after verapamil reduces its hypotensive effect).
• With simultaneous use with quinidine, it is possible to slow intraventricular conduction and increase the toxicity of quinidine.
• During treatment with cardiac glycosides, parenteral use of calcium gluconate is not recommended (possibly increased cardiotoxic effect of glycosides). Slows down the absorption of tetracyclines, digoxin, oral Fe preparations (the interval between their doses should be at least 2 hours).
• When combined with thiazide diuretics, it can increase hypercalcemia, reduce the effect of calcitonin in hypercalcemia, and reduce the bioavailability of phenytoin.

Description of the drug

Calcium gluconate is not intended for prescribing treatment without the participation of a doctor, and is dispensed in pharmacies without a prescription.

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See what "Calcium gluconate" is in other dictionaries:

Active ingredient ›› Calcium gluconate (Calcium gluconate) Latin name Calcii gluconas ATX: ›› A12AA03 Calcium gluconate Pharmacological group: Macro and microelements Nosological classification (ICD 10) ›› D65 D69 Violations ... ... Medicine Dictionary

CALCIUM GLUCONATE- Calcii gluconas. Properties. White granular or crystalline powder. Slowly soluble in water (1:50 cold and 1:5 boiling), practically insoluble in alcohol and ether. Contains up to 9% calcium. Sterilized at 110°C for one hour. Form in… Domestic veterinary drugs