Ointment Dolobene: instructions for use and analogues. Dolobene - instructions for use The product and its components act as follows

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Bruises and injuries, accompanied by hematomas and sprains, cause severe pain. liquidate quickly, through a complex effect on the center of pain is capable of Dolobene gel. This drug has a wide range of effects, allowing you to stop the acute pain of damaged soft tissues. How to use it correctly and for what purposes, as well as possible adverse reactions and contraindications, we will consider further.

Pharmacological action and pharmacokinetics

Dolobene gel is a complex drug capable of exerting the following effects on soft tissues:

• analgesic;
• regenerating;
• decongestant;
• anti-inflammatory;
• antithrombotic.

This is achieved due to the influence on the tissues of the constituent components, which, both independently and in combination, have an instant therapeutic effect. Three active ingredients, which play a key role, are capable of:

1. Heparin- creates conditions for the inhibition of the synthesis of hyaluronidase, due to which there is a pronounced regeneration of muscle fibers. It is also able to influence the viscosity of the blood, making it more liquid, reducing the likelihood of blood clots. It is well absorbed through the skin, penetrating to the site of inflammation.
2. - inhibits hydroxyl radicals involved in the formation of inflammation, swelling and pain. It also affects the conductivity of neuron endings, reducing their sensitivity. Due to this, analgesic, anti-edematous and anti-inflammatory effects are observed. Dimethyl sulfoxide, interacting with other components, is able to enhance and activate their activity, increasing the effect of the gel.
3. - is transformed in tissue cells into pantothenic acid, whose task is to restore muscle fiber, by accelerating regeneration processes at the cellular level. It is this component that allows you to reduce the duration of natural regeneration to 2-3 days.

Dolobene gel penetrates well through the skin to the focus of inflammation acting locally. First results are noticeable in 5-10 minutes when there is a marked reduction in pain, swelling and inflammation. Complete excretion of the metabolites of the drug is noted after 5-7 days from the moment the gel is applied to the skin. Absorbed in the liver and kidneys, but the concentration is negligible, which allows the use of the drug for the full and long-term treatment of injuries of various etiologies.

Composition and form of release

Dolobene is produced in the form of a transparent gel, with a specific alcohol smell, in a metal tube, with a volume of 50 and 100 g.

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100 g of gel contains the following amount of active ingredients:

• dexpanthenol - 2.5 g;
• heparin sodium - 50,000 IU;
• dimethyl sulfoxide - 15.2 g.

Excipients:

• isopropanol;
• polyacrylic acid;
• natural flavors, in the form of essential oils: pine, rosemary, citronella;
• distilled water;
• trometamol.

Application

Dolobene gel is used to eliminate the following manifestations:

• inflammatory processes of soft tissues;
• swelling;
• hematomas;
• stretching of the tendons;
• bruises;
• closed injuries with violation of the integrity of soft tissues;
• diseases accompanied by inflammation of certain parts of the body: tendovaginitis, tendonitis, bursitis, periarthritis,.

The drug can be used externally in three ways:

1. Apply evenly on the skin- apply to pre-cleansed dry skin, with soft massaging movements until completely absorbed. To do this, squeeze out the gel in the volume of a large cherry and rub it well into the sore spot.
2. Application under the bandage- it is necessary when a tight bandage or elastic bandage is applied (mainly for injuries of the limbs). Apply to the skin and wait for the complete evaporation of the alcohol part of the gel, only then apply a bandage.
3. Under cathode iontophoresis– a gel with good conductivity can be used in iontophoresis by placing it under the cathode (negative conductor). Electrical impulses supplied through the device allow you to accelerate the absorption and activation of the active components of the gel.

The duration of the course of treatment with the drug is prescribed on an individual basis, and depends on the severity and characteristics of the inflammatory process of soft tissues. In most cases, treatment does not exceed 2-3 weeks. If long-term treatment is necessary and used in complex therapy to eliminate chronic diseases, a break is made every 2-3 weeks, after which the process continues.

Contraindications

In 99% of cases, Dolobene gel is well tolerated by patients, but it is categorically not recommended for the following categories of people:

• in the presence of chronic diseases of the liver and kidneys, in the acute stage;
• bronchial asthma;
• pregnancy and breastfeeding;
• children's age up to 12 years;
• individual intolerance to the components;
• the presence of open wounds at the site of application, as well as chronic diseases of the skin.

The presence of contraindications indicates the need to consult a doctor before applying the drug to the skin. Instructions for use are not able to indicate the seriousness and danger of using the gel, in the presence of certain health problems.

With caution, you need to use the gel in the treatment of hematomas and bruises, which are located directly above the scars and old scars. Colloidal scars and skin seals (after suturing or medical staples in violation of the integrity of the skin) can become a vulnerable place for the development of adverse reactions.

During the period of applying the gel to the skin, direct contact with the sun's rays should be limited, which can provoke an extensive burn.

Overdose

Data on the occurrence of an overdose of the drug are not provided by the manufacturer. Most likely, this is due to a small concentration of active ingredients that are quickly absorbed and are not capable of causing signs of intoxication.

Side effects

The most rare side reactions of Dolobene gel are:

• nausea and headache;
• lack of smell and the presence in the oral cavity and nasopharynx of the smell of garlic;
• difficulty breathing and chest cough.

Adverse reactions develop for three reasons:

1. Non-compliance with recommended dosages.
2. Use in the presence of serious diseases.
3. Applying a gel that has long expired.

The most common manifestations of adverse reactions are the following symptoms:

• redness of the skin in a limited area of ​​application of the gel;
• itching and burning;
• short-term loss of taste.

Sometimes there are cases of the development of an allergic reaction, which is characterized by the following symptoms:

• the development of urticaria not only at the site of application of the gel, but throughout the body;
• dryness and swelling of the mucous membranes;
• angioedema;
• anaphylactic shock.

The last two manifestations are deadly to humans. and require immediate elimination. They arise as a result of severe intoxication, which is caused by the release into the blood of a large number of cells that are seen in the preparation as “enemy cells”. To eliminate an allergic reaction, you need:

1. Call an ambulance - if a person has difficulty breathing, he loses consciousness and has no signs of life. During the time that the ambulance is driving, you need to do artificial respiration and indirect heart massage, as well as inject 1 ampoule of adrenaline.
2. To give a person an antihistamine, it is better to make an intramuscular injection, which will allow you to get the effect much faster than the tablet will dissolve. Such drugs are suitable: Suprastin, Diphenhydramine, Diazolin.
3. Try to remove the remnants of the gel from the skin, although this is extremely difficult to do, since its alcohol base makes the drug easily carried to the site of inflammation.
4. Provide plenty of fluids and bed rest.
5. Cancel the application of the gel, as well as report the fact of the development of an allergic reaction to the attending physician.

In the presence of an extensive drug allergy in remission, taking Dolobene gel is recommended in a hospital, where, if necessary, the patient can be provided with qualified assistance by carrying out appropriate resuscitation. Before starting treatment, a test application of a small amount of gel is made, observing the development of the clinical picture.

Interaction with other drugs

The simultaneous use of the gel and other creams and ointments with a similar effect is not recommended. especially for non-steroidal anti-inflammatory drugs. Dolobene gel is able to enhance the conductivity of other applied creams, so its use should be separated from the application of other drugs on the same area of ​​the skin.

Advantages

The main advantage of the drug is its complex effect, which allows you to carry out in three directions at the same time: pain relief and removal of puffiness, elimination of inflammation, regeneration of damaged fibers and skin cells. The effect of the treatment is noted from the first application of the gel. The alcohol base freezes pain by rapidly evaporating moisture from the skin, helping to enhance the analgesic effect.

Price

Average price for Dolobene gel:

• tuba 100 g - 750 rubles;
• tuba 50 g - 330 rubles.

Terms of dispensing from pharmacies

It is available in pharmacies without a prescription, but you need to consult a doctor before using it.

Storage conditions and shelf life

After opening, the tube should be hermetically sealed with a lid. Store in a cool place for no more than 3 years from the date of manufacture. After the specified period, the effectiveness of the drug can be significantly reduced.

Analogues

Drugs with a similar complex effect on soft tissues:

• Dexpanthenol - 65 rubles;

• Dioflan gel - 250 rubles;

• Venohepanol - 280 rubles;

• - 35 rubles;

• Heparin ointment - 75 rubles.

Thus, Dolobene gel has a unique complex effect on soft tissues, allowing you to quickly and painlessly eliminate bruises, sprains, hematomas and pain caused by inflammatory processes in soft tissues.

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In this article, you can read the instructions for using the drug Dolobene. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Dolobene in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Dolobene in the presence of existing structural analogues. Use to treat bruises, bruises and injuries in adults, children, and pregnancy and lactation. The composition of the drug.

Dolobene- a combined preparation for external use. The action of the drug is due to its active substances: heparin sodium, dexpanthenol, dimethyl sulfoxide.

Dimethyl sulfoxide has anti-inflammatory, anti-edematous and local analgesic effects. Anti-inflammatory activity is associated with several pharmacological effects, the most significant of which is the inactivation of hydroxyl radicals, which are produced in large quantities during the inflammation process and have a destructive effect on tissues.

Dimethyl sulfoxide has a local analgesic effect by reducing the speed of nociceptive (pain) impulses in peripheral neurons. The anti-edematous effect is provided by the inactivation of hydroxyl radicals and the improvement of the subcutaneous metabolic reaction at the site of application of the drug. To a certain extent, the anti-edematous effect of dimethyl sulfoxide is due to its hygroscopic properties.

Dimethyl sulfoxide (from 50% or more) penetrates through biological membranes, incl. through the skin, contributing to a better and deeper penetration into the tissues of other drugs used simultaneously with it.

Heparin has an anti-inflammatory effect, promotes the regeneration of connective tissue by inhibiting the activity of hyaluronidase. It has a dose-dependent antithrombotic effect, enhancing the inhibitory activity of antithrombin 3 on the activation of prothrombin and thrombin. The penetration of heparin through healthy skin is dose-dependent and is confirmed for doses starting from 300 IU/g.

Dexpanthenol, when applied topically, is transformed in the skin into pantothenic acid (vitamin of group B). The effectiveness of dexpanthenol is comparable to that of pantothenic acid. Pantothenic acid, as a component of coenzyme A, is involved in various catabolic and anabolic processes in tissues, by improving the processes of granulation and epithelization, it promotes the regeneration of damaged skin areas.

Compound

Sodium heparin + Dexpanthenol + Dimethyl sulfoxide, 10% H2O + excipients.

Pharmacokinetics

When using dimethyl sulfoxide 1 g 3 times a day for 5 days, its average content at the site of application to the skin is 3 mg / g, the average content in the underlying muscle tissues and synovial membrane at the site of the synovial junction is 7-10 μg / ml, in the synovial liquids - 0.8 mcg / g. The concentration of dimethyl sulfoxide in blood plasma is 0.5 µg/g.

Heparin is slightly absorbed when applied topically.

When applied externally, dexpanthenol is transformed in the skin into pantothenic acid. Good absorption of dexpanthenol has been experimentally confirmed.

12-25% of absorbed dimethyl sulfoxide is excreted within the first 24 hours and 37-48% is excreted within 7 days unchanged by the kidneys or as a metabolite (dimethyl sulfone). 3.5-6% of the total dimethyl sulfoxide is excreted through the lungs in the form of dimethyl sulfide 6-12 hours after the use of the drug.

Indications

• swelling, hematomas (bruises) and inflammation of soft tissues, muscles, tendons, tendon sheaths;
• closed injuries, bruises;
• joint injuries with sprains and tendons;
• epicondylitis of the shoulder ("tennis player's elbow"), tendinitis (inflammation of the tendons), tendovaginitis (inflammation of the tendon sheaths), bursitis (inflammation of the mucous bag of the joint);
• periarthritis of the shoulder joint;
• acute neuralgia.

Release forms

Gel for external use (sometimes mistakenly called an ointment or cream).

There are no other dosage forms, whether tablets or solution.

Instructions for use and method of use

Dolobene should be applied as a surface layer on the skin over the affected area of ​​the skin 2-4 times a day.

When using the gel under the bandage, apply the gel and wait a few minutes for it to be absorbed by the skin and the isopropanol to evaporate. Then you can apply an airtight bandage.

Dolobene can be used for iontophoresis. The drug is applied under the cathode.

Dolobene as a contact gel can be used in ultrasound therapy (phonophoresis). The active substances of the gel complement the therapeutic effect of ultrasonic waves.

The duration of treatment depends on the severity of the symptoms and the severity of the disease.

Side effect

• possible skin reactions (redness, itching, burning sensation at the site of application of the gel), which usually disappear during further treatment;
• hives;
• angioedema;
• smell of garlic from the mouth (caused by dimethyl sulfide, which is a product of the metabolism of dimethyl sulfoxide);
• a change in taste sensations is possible (disappear a few minutes after applying the gel);
• nausea;
• diarrhea;
• difficulty breathing;
• headache;
• chills.

Contraindications

• severe liver dysfunction;
• severe renal dysfunction;
• bronchial asthma;
• severe disorders of the cardiovascular system;
• open wounds at the site of application;
• pregnancy;
• lactation period;
• children's age up to 5 years;
• hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The use of the drug Dolobene is contraindicated during pregnancy due to the lack of data from clinical studies.

The use of Dolobene during breastfeeding is contraindicated, since dimethyl sulfoxide is excreted in breast milk.

Use in children

Contraindicated in children under the age of 5 years.

special instructions

Before applying Dolobene, the skin should be thoroughly cleansed of other medicines, cosmetics or any chemicals.

Dolobene should not be applied to the mucous membranes of the eyes, nose, mouth, open wounds or damaged areas of the skin (due to exposure, severe sunburn, postoperative scars).

During treatment with the drug, the photosensitivity of the skin may increase, therefore, during the period of its use, intense sunbathing and visits to the solarium should be limited.

In the event of skin reactions, treatment should be discontinued.

Due to the high absorption of dimethyl sulfoxide, Dolobene should not be used in combination with other ointments and gels.

drug interaction

When used externally together, Dolobene may enhance the penetration of other drugs through the skin.

With the simultaneous use of drugs containing sulindac (NSAIDs), with the drug Dolobene, the development of peripheral neuropathy is possible.

Analogues of the drug Dolobene

Structural analogues for the active substance:

• Hepatrombin C.

Analogues by pharmacological group (anticoagulants):

• Angioks;
• Angioflux;
• Anfibra;
• Arikstra;
• Acenocoumarol;
• Warfarex;
• Warfarin;
• Venabos;
• Venolife;
• Viatromb;
• Gemapaksan;
• Gepalpan;
• Heparin;
• Heparin ointment;
• Hepatrombin;
• Ellon gel;
• Calciparin;
• Clexane;
• Klivarin;
• Xarelto;
• Lavenum;
• Lyoton 1000;
• Marevan;
• Nigepan;
• Pelentan;
• Piyavit;
• Leech medical;
• Pradax;
• Seprotin;
• Sincumar;
• Skinlight;
• Trombless;
• Thrombophobic;
• Troparin;
• Phenylin;
• Fragmin;
• Fraxiparine;
• Fraxiparin Forte;
• Cibor;
• Exanta SC;
• Eliquis;
• Emeran;
• Essaven.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

In 100 grams, the active ingredients are contained in the amount of 2.5g / 50 thousand IU / 16.66g.

Additional substances:

• Cremophor;
• rosemary oil;
• trometamol;
• polyacrylic acid;
• water;
• citronella oil (a kind of lemongrass);
• mountain pine oil;
• isopropanol.

Release form

Dolobene gel has a yellowish tint. Produced in special tubes made of aluminum 50/100 grams.

pharmachologic effect

Multicomponent means of external application. A pronounced therapeutic effect is achieved by the complex action of three active components.

Dimethyl sulfoxide renders anti-edematous, anti-inflammatory and local anesthetic action . The anti-inflammatory effect is achieved due to the inactivation of various hydroxyl radicals , which are produced in large volumes during the inflammatory process. Radicals are destructive to tissues. The local anesthetic effect is provided by slow conduction of pain (nociceptive) impulses in peripherally located neurons. The anti-edematous effect is achieved by improving the subcutaneous fat in the area of ​​gel application. The anti-edematous effect is also achieved due to the hygroscopicity of Dimethyl sulfoxide. The active ingredient easily passes through the skin and other biological membranes, contributing to a more pronounced, deep penetration into the tissues of the drugs used together.

Heparin has anti-inflammatory effect, improves connective tissue. The effect develops due to the suppression of activity Hyaluronidase . Heparin is characterized antithrombotic effect , which is dose dependent. The active ingredient enhances the inhibitory effect of antithrombin-3 on the activation of thrombin and prothrombin. The degree of penetration of the drug through healthy skin is dose-dependent and is recorded from a dose of more than 300 IU per gram.

Dexpanthenol able to transform into group B - pantothenic acid when used locally. The effectiveness of the component is fully comparable with the effectiveness of Pantothenic acid. The latter is a part and takes an active part in anabolic reactions, catabolic processes in tissues. The regenerative effect in damaged tissues is achieved by improving processes epitalization and granulation .

Pharmacodynamics and pharmacokinetics

suction, distribution

The indicator of the physiological concentration of one of the active substances Dimethyl sulfoxide is normally equal to 40 ng / ml. 6 hours after application of the gel, C(max) is 120 ng/ml and can be maintained up to 12 hours after application. The concentration of the Dimethyl sulfoxide component reaches a physiological value of 40 ng / ml 60 hours after the use of the drug. If you apply the gel 3 times a day, 1 gram for 5 days, then the average content at the site of application will be 3 mg / g on the skin, 0.8 μg / g - in synovial fluid and 7-10 mcg/ml in synovial membrane in the area of ​​the synovial junction and in the underlying muscle tissues. When applied externally, one of the active components of Heparin practically does not enter the systemic circulation. Dexapanthenol is converted to pantothenic acid when applied topically. Good absorption of Dexpanthenol has been experimentally proven.

breeding

The period T1 \ 2 of the active substance Dimethyl sulfoxide is 11-14 hours. During the first day, 12-25% of the absorbed Dimethyl sulfoxide is excreted; within a week - 37-48% in the form of dimethyl sulfone and unchanged through the renal system. After 6-12 hours, 3.5-6% of the total dimethyl sulfoxide is excreted through the pulmonary system.

Indications, application of ointment (from which ointment)

• bruises;
• traumatic injuries (closed forms);
• and inflammatory processes in soft tissues, tendons and their sheaths;
• soft tissues;
• periarthritis of the shoulder joint ;
• traumatic injuries of the joints, accompanied by stretching of the tendons and ligaments;
• brachial epicondylitis ("tennis elbow");
• (inflammatory processes with articular bags);
• tendovaginitis (inflammatory processes in the tendon sheaths);
• (inflammatory processes in the tendons).

Contraindications

• open wound injuries in the area of ​​application of the gel;
• severe pathology of the liver system;
• pathology of the heart, vascular system;
• pronounced changes in the functioning of the renal system;
• gestation;
• age limit - up to 5 years;

Side effects

Local reactions (disappear on their own after discontinuation of the drug):

• burning ;
• redness skin (mild, moderately pronounced);
• at the site of application of the gel.

Allergic responses:

• skin reactions.

Other negative reactions:

• change in taste perception;
• the smell of garlic from the oral cavity (occurs as a result of dimethyl sulfoxide with the formation of dimethyl sulfide);
• chills;
• difficulty breathing;
• nausea.

Gel Dolobene, instructions for use (Method and dosage)

The ointment is applied to the skin over the affected area with a thin layer 2-4 times a day. If it is necessary to apply a dressing, the gel is left for several minutes after application for greater absorption and for the evaporation of the isopropanol. Next, a special sealed bandage is applied.

Instructions for use Dolobene for iontophoresis, phonophoresis

The gel is distributed evenly over the cathode application area. The active components of Dolobene enhance the therapeutic effect of ultrasonic waves. The decision on the duration of therapy is made by the doctor, based on the severity of the symptoms of the underlying disease, tolerability.

Overdose

Adequate data on this section from the manufacturer are not available.

Interaction

When applied externally, Dolobene ointment can enhance the therapeutic effect of other medicinal products by enhancing the penetration of active substances. Possible development peripheral neuropathy with the simultaneous use of medicines, which include Sulindak from the group of NSAIDs.

Terms of sale

Gel Dolobene is released in specialized pharmacies. You do not need to present a prescription form.

Storage conditions

The gel should be stored in its original packaging (aluminum tubes) at temperatures up to 25 degrees.

Best before date

The effectiveness of the drug is maintained for 3 years, subject to the recommendations recommended by the manufacturer.

special instructions

The skin before applying the Dolobene gel must be cleaned of other medicines, chemicals and cosmetics. It is not allowed to apply the medication to the mucous membranes of the nose, eyes, mouth, to open wound injuries of the skin (postoperative scars, due to radiation, sunburn).

During treatment, an increased photosensitivity skin, which requires patients to limit their visits to the solarium and avoid intense solar radiation. With the manifestation of various skin reactions, therapy is stopped. It is not recommended to use simultaneously with other gels and ointments due to the high absorption of dimethyl sulfoxide.

Dolobene gel is an anti-inflammatory, decongestant, analgesic drug that is intended for external use.

Although there are many similar drugs on the pharmaceutical market, it is the most popular, as it is a universal remedy for sprains, bruises and other injuries in everyday life and during sports.

On this page you will find all the information about Dolobene: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Dolobene gel. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A drug with anti-inflammatory, antiexudative, analgesic, antithrombotic and tissue regeneration-improving action for external use.

Terms of dispensing from pharmacies

Released without a prescription.

Prices

How much is Dolobene worth? The average price in pharmacies is at the level of 400 rubles.

Release form and composition

Dolobene is produced in the form of a gel, the color of which is from transparent to slightly cloudy, from colorless to slightly yellowish. The drug is packaged in tubes of 50 and 100 g.

The composition of the gel includes 3 active ingredients:

1. Dexpanthenol;
2. Heparin sodium;
3. Dimethyl sulfoxide.

In 100 grams, the active ingredients are contained in the amount of 2.5g / 50 thousand IU / 16.66g.

Pharmacological effect

The agent has anti-inflammatory, antithrombotic and analgesic effects. This medicine comes in the form of a gel. Its properties are influenced by the active ingredients included in the composition:

1. Heparin improves microcirculation, acts as an anti-inflammatory agent. It helps regenerate connective tissue.
2. Dexpanthenol promotes rapid regeneration of damaged tissues. It has a softening and anti-inflammatory effect, stimulates the processes of epithelialization. It is one of the components of the coenzyme, therefore it is involved in many metabolisms. Thanks to him, the tolerance of Dolobene-gel improves.
3. Dimethyl sulfoxide relieves inflammation, swelling and has a local analgesic property. During inflammation in soft tissues, hydroxyl radicals are produced in large quantities, which can destroy tissues around. The active substance Dimethyl sulfoxide inhibits their activity and stops the inflammatory process, and also relieves swelling. The pain syndrome is reduced due to the fact that, due to the action of the substance, the conduction of pain impulses in neurons decreases. Dimethyl sulfoxide also locally improves subcutaneous metabolic reactions. The active substance contributes to a more effective and deeper conduction of other drugs, if used simultaneously with Dolobene gel.

Indications for use

What helps? Dolobene gel is used in the following cases:

• with soft tissue edema;
• with thrombophlebitis;
• with acute neuralgia;
• when stretching muscles, tendons and ligaments;
• with periarthritis of the shoulder joints;
• with inflammation of the tendons (tendinitis) and tendon sheaths;
• with bruises, injuries with intact skin;
• with diseases of the musculoskeletal system, including with, with,;
• with hematomas and joint injuries.

Contraindications

Contraindications to the use of Dolobene are:

1. Bronchial asthma.
2. Children's age up to 5 years.
3. Open wounds (in particular, at the site of application of the drug).
4. Severe functional disorders of the liver.
5. The period of bearing a child and breastfeeding.
6. Severe disorders of the cardiovascular system.
7. Hypersensitivity to the main and auxiliary components of the drug.

Use during pregnancy and lactation

It is forbidden to use Dolobene gel during pregnancy. There are no data from clinical studies on the effect of the drug on fetal development, so doctors prefer not to risk the health of the mother and baby.

If there is a need to use the drug during the period of breastfeeding a child (lactation), the baby should be transferred to artificial nutrition, since it has been proven that the active substance dimethyl sulfoxide can be excreted in breast milk.

Instructions for use

The instructions for use indicate that Dolobene gel is applied to the surface of the skin directly above the damaged area 2-4 times a day. The freshly applied gel should not be covered with a bandage. It is necessary to wait until the gel completely penetrates the skin, and then make a tight tight bandage. Dolobene is used in physiotherapeutic procedures (iontophoresis) under the cathode.

It is also used in phonophoresis as a contact gel. Thanks to the active substances of the drug, the therapeutic effect of ultrasound therapy increases.

The duration of exposure to the drug depends on the symptoms of the disease.

Side effects

The drug may contribute to the development of the following undesirable side effects:

1. Allergic reactions: urticaria, in rare cases -.
2. Local skin reactions: a feeling of itching and burning at the site of application, redness.

Other side effects: in some cases, the patient may begin to be disturbed by the unpleasant smell of garlic from the mouth. This is due to the presence of dimexide in the preparation. There is a possibility of taste disturbance. Nausea, headache, stool disturbance, difficulty in breathing may begin.

Overdose

Data on the occurrence of an overdose of the drug are not provided by the manufacturer. Most likely, this is due to a small concentration of active ingredients that are quickly absorbed and are not capable of causing signs of intoxication.

special instructions

1. In the event of skin reactions, treatment should be discontinued.
2. Before applying Dolobene, the skin should be thoroughly cleansed of other medicines, cosmetics or any chemicals.
3. During treatment with the drug, the photosensitivity of the skin may increase, therefore, during the period of its use, intense sunbathing and visits to the solarium should be limited.
4. Due to the high absorption of dimethyl sulfoxide, Dolobene should not be used in combination with other ointments and gels.
5. Dolobene should not be applied to the mucous membranes of the eyes, nose, mouth, open wounds or damaged areas of the skin (due to exposure, severe sunburn, postoperative scars).

drug interaction

When used externally together, Dolobene may enhance the penetration of other drugs through the skin.

With the simultaneous use of drugs containing sulindac (NSAIDs), with the drug Dolobene, the development of peripheral neuropathy is possible.

Advantages

The main advantage of the drug is its complex effect, which allows you to carry out in three directions at the same time: pain relief and removal of puffiness, elimination of inflammation, regeneration of damaged fibers and skin cells. The effect of the treatment is noted from the first application of the gel.

The alcohol base freezes pain by rapidly evaporating moisture from the skin, helping to enhance the analgesic effect.

Tradename: Dolobene

International non-proprietary name (INN): -

Dosage form:

Compound:

Description:
Clear to slightly cloudy and colorless to slightly yellowish gel.

Pharmacological group: anticoagulant agent of direct action for local use + other drugs.

ATC code: C05BA53

Pharmachologic effect:

Pharmacodynamics:

Dimethyl sulfoxide (DMSO).
DMSO has anti-inflammatory, decongestant and local analgesic effects.

Anti-inflammatory activity is associated with several pharmacological effects, the most significant of which is the inactivation of hydroxyl radicals, which are produced in large quantities during the inflammation process and have a destructive effect on tissues.

DMSO has a local analgesic effect by reducing the speed of nociceptive (pain) impulses in peripheral neurons. The anti-edematous effect is provided by the inactivation of hydroxyl radicals and the improvement of the subcutaneous metabolic reaction at the site of application of the drug. To a certain extent, the hygroscopic properties of DMSO are also responsible for its decongestant action. DMSO (from 50% or more) penetrates through biological membranes, including through the skin, contributing to a better and deeper penetration into the tissues of other drugs used simultaneously with it.

Heparin.
Heparin has an anti-inflammatory effect, promotes the regeneration of connective tissue by inhibiting the activity of hyaluronidase. Heparin exhibits a dose-dependent antithrombotic effect, enhancing the inhibitory activity of antithrombin III on the activation of prothrombin and thrombin. The penetration of heparin through healthy skin is dose-dependent and is confirmed for dosages starting from 300 IU/g.

Dexpanthenol.
When applied topically, dexpanthenol is transformed in the skin into pantothenic acid (vitamin B). The effectiveness of dexpanthenol is comparable to that of pantothenic acid. Pantothenic acid, as a component of coenzyme A, is involved in various catabolic and anabolic processes in tissues, by improving the processes of granulation and epithelization, it promotes the regeneration of damaged skin areas.

Pharmacokinetics:

Dimethyl sulfoxide (DMSO).
The physiological concentration of DMSO in normal blood plasma is 40 ng/ml. 6 hours after application of the drug, the maximum plasma concentration reaches 120 ng / ml and lasts up to 12 hours after application. 60 hours after application, the concentration of DMSO in blood plasma reaches the physiological level of 40 ng / ml. 12-25% of absorbed DMSO is excreted within the first 24 hours and 37-48% is excreted within 7 days unchanged via the kidneys or as a metabolite (dimethylsulfone). 3.5-6% of the total DMSO is excreted through the lungs in the form of dimethyl sulfide 6-12 hours after the use of the drug.

When using 1 g of dimethyl sulfoxide 3 times a day for 5 days, its average content at the site of application to the skin is 3 mg / g, the average content in the underlying muscle tissues and synovial membrane at the site of the synovial junction is 7-10 μg / ml, in the synovial liquid - 0.8 mcg / g. The concentration of dimethyl sulfoxide in plasma is 0.5 µg/g. The half-life of DMSO is 11-14 hours.

Heparin.
With external use, heparin is slightly absorbed.

Dexpanthenol.
When applied externally, dexpanthenol is transformed in the skin into pantothenic acid. Good absorption of dexpanthenol has been experimentally confirmed.

Indications for use:

• swelling, bruising and inflammation of soft tissues, muscles, tendons, tendon sheaths,
• closed injuries, bruises,
• joint injuries with sprained ligaments and tendons,
• epicondylitis of the shoulder ("tennis elbow"), tendinitis (inflammation of the tendons), tendovaginitis (inflammation of the tendon sheaths), bursitis (inflammation of the mucous bag of the joint),
• periarthritis of the shoulder joint,
• acute neuralgia.

Contraindications:

• hypersensitivity to one of the components of the gel (active / excipients),
• bronchial asthma,
• severe disorders of the liver, kidneys,
• severe disorders of the cardiovascular system,
• pregnancy and lactation,
• age up to 5 years,
• open wounds at the site of application.

Use during pregnancy and lactation:

Use during pregnancy.
Since there are no data from studies on the use of the drug in pregnant women, its use during pregnancy is contraindicated.

Use during lactation.
Dimethyl sulfoxide passes into breast milk, therefore, during the use of the drug, breast-feeding should be stopped.

Dosage and administration:

When using the gel under the bandage, apply the gel and wait a few minutes for it to be absorbed by the skin and the isopropanol to evaporate. Then you can apply an airtight bandage.

Dolobene can be used for iontophoresis. The drug is applied under the cathode. Dolobene as a contact gel can be used in ultrasound therapy (phonophoresis). The active substances of the gel complement the therapeutic effect of ultrasonic waves. The duration of treatment depends on the severity of the symptoms and the severity of the disease.

Side effect:

In rare cases, during the use of the drug, some patients may experience the smell of garlic from the mouth. The smell is caused by dimethyl sulfide, which is a product of the metabolism of dimethyl sulfoxide. There may be a change in taste sensations that disappear a few minutes after applying the gel.

In isolated cases, allergic reactions of the immediate type (urticaria, Quincke's edema) may occur. Extremely rarely, when the drug is applied to large areas of the body, nausea, diarrhea, difficulty breathing, headache, chills may occur.

Overdose:

Interaction with other drugs:

Special instructions:

During treatment with the drug, the photosensitivity of the skin may increase, therefore, during the period of its use, intense sunbathing and visits to the solarium should be limited. In the event of skin reactions, treatment should be discontinued. Due to the high absorption of dimethyl sulfoxide, Dolobene should not be used in combination with other ointments and gels.

Release form:

Storage conditions:

Best before date:

Leave conditions:
Released without a prescription.

Manufacturer
Merkle GmbH, Ludwig-Merklestrasse 3, D-89143, Blaubeuren, Germany.

Organization authorized to accept claims from consumers:
Ratiopharm RUS LLC, 105064, Moscow, st. Zemlyanoy Val, 9 (DC CITYDEL)