Dicinon - indications for use and important rules for taking the medicine. Dicinon tablets - official instructions for use

Dicynon tablets- instructions for use - take orally, during or after a meal, with water.
Dicynon solution for injections in ampoules (injections)– instructions for use

1. Enter intravenously, slowly.
2. Introduce intramuscularly, before heating the solution to a temperature of 30-35 ° C.
3. Locally - apply a napkin moistened with a solution to the area of ​​capillary bleeding.

Dicinon instructions for use for menstrual and uterine bleeding

With menstruation, Dicinon is prescribed:

1. In tablets - in order to reduce intense discharge, 1-2 tablets 2-3 times a day.
2. In solution for injection - with severe bleeding, the starting dose is 1-2 ampoules, followed by injections of 1-2 ampoules every 4-6 hours.

1. To prevent chronic hemorrhage - 2 tablets 3 times a day. The course starts 5 days before the end of the menstrual cycle, duration - 10 days.
2. For the treatment of acute uterine bleeding - intramuscularly or intravenously, an introductory dose of 2 ampoules, then 1-2 ampoules every 4-6 hours, until bleeding is eliminated.

Dicinon during pregnancy - instructions for use

During early pregnancy, Dicinon is prescribed in the absence of danger to the embryo, only in tablets. In the 2nd and third trimesters it is used:

1. To eliminate minor bleeding.
2. With detachment of the elements of the placenta.
3. To combat nasal hemorrhages.

Dicynon dosage

The dose of the drug depends on the pathology and indications.

1. Therapy of chronic hemorrhages - 1-2 tablets 2-3 times a day.
2. Before surgery - 1-2 tablets (0.25 - 0.5 g), or 1-2 ampoules an hour before the start. With severe blood loss, repeated administration is possible.
3. Therapy of acute hemorrhages - 3-4 ampoules or 3-4 tablets 2-3 times a day.
4. With the destruction of retinal vessels in diabetes - 1-2 tablets 3 times a day.
5. For children, the dose is halved.

Composition and form of release

Dicynon Tablets

1. The active substance is etamsylate, 0.25 g.
2. Additional substances - anhydrous citric acid, starch, povidone K25, magnesium stearate, milk sugar.

Dicynon Solution for injection

1. The active substance is etamsylate 0.125 g per ml, 0.25 g per ampoule.
2. Additional substances - injection water, sodium disulfite, sodium bicarbonate.

Packaging and price

Tablets- 10 white tablets in a paper blister, 10 blisters per pack. Price - 32 UAH / 87 rubles. for 10 tablets.
Injection- transparent glass ampoules, 2 ml each, 10 pieces in a blister, 5 blisters in a pack. Price - 35 UAH / 94 rubles. for 10 ampoules.

Vitamin K preparations

Pharmacological properties

Etamzilat is a powerful hemostatic agent, improving the contact between the endothelium and platelets. It reduces the permeability of capillaries and the synthesis of substances that destroy blood clots and dilate blood vessels. As a result, platelets adhere better to the vascular wall at the site of integrity violations, significantly reducing blood loss.

digestibility

After taking the tablets, they are completely absorbed in the small intestine. The maximum level of the active substance in the blood is observed after 3.5-4 hours. More than 90% of the drug binds to plasma proteins.

With parenteral administration, the pharmacological effect appears after 5-30 minutes, depending on the method of application. The maximum level in the blood is observed after 40-60 minutes. Plasma proteins bind 85-90% of the drug.

Etamzilat enters the fetal circulation, there is no data on excretion with milk. The half-life in the blood is 1.5-2 hours. A day after use, 75% of the drug is excreted in the urine in its pure form.

Overdose

Cases of overdose Dicinon are unknown.

Dicinon indications for use

Dicinon is indicated in such cases:
• Prevention and therapy of bleeding during surgical interventions.
• The fight against bleeding from small vessels in diseases of the kidneys, uterus, nasal injuries, pathological menstruation.
• To prevent periventricular bleeding in preterm infants.
• With diabetes-related hemorrhages in the structures of the eye.

Dicinone contraindications

Reception of Dicinon is contraindicated in:
• Individual intolerance to the components of the drug.
• Expressed porphyria.
• Decreased clotting time.
• Tendency to form blood clots.
• Osteosarcoma.

Dicynon side effects

Taking Dicynon can cause the following side effects:
Nervous system
• Migraine.
• Disorders of the vestibular apparatus.
• Hypersensitivity of the skin of the legs.
Digestive system
• Vomit.
• Discomfort in the stomach.
• Heartburn.
Other systems
• Skin rash.
• Drop in blood pressure.
• Redness of the face.

special instructions

1. Dicynone is ineffective with a lack of platelets in the blood.
2. If a weekly course of taking Dicinon did not cause a decrease in pathological discharge during menstruation, you should consult a doctor for re-diagnosis.
3. Use with caution in patients with unstable blood pressure.
4. It is forbidden to use Dicinon when the solution acquires a reddish tint.
5. In the absence of symptoms of side effects does not affect the reaction rate.

Interaction

1. Do not mix in the same container with other drugs, with the exception of solutions for intravenous administration.
2. With simultaneous use with aminocaproic acid, the hemostatic effect of Dicinon is enhanced.
3. Simultaneous reception with Trunksam is prohibited.
4. Dicinone may reduce the biological effectiveness of thiamine.
5. After adding the drug to an isotonic saline solution, it must be used up immediately.
6. Dicinone and alcohol are incompatible - simultaneous use increases the risk of blood clots.

Terms of sale

Prescription sale.

Storage conditions and shelf life

Store in a dark place at a temperature of 15-25 ° C. Shelf life 3 years from the date of production.

Dicinon reviews for menstruation and bleeding

Most of the women interviewed noted the high effectiveness of Dicinon to combat heavy bleeding during menstruation and uterine bleeding. Side effects were observed rarely, and were manifested mainly by a skin rash.

Doctors note the powerful hemostatic effect of Dicinon in the prevention and treatment of post-traumatic and postoperative bleeding. Occasionally, there is a short drop in blood pressure due to intravenous use.

Kalorizator 2019 - Vitamins, instructions for medicines, proper nutrition. All information is for informational purposes only. When treating, be sure to consult a doctor.

Dicynon has been used for many years in various fields of medicine as a prophylactic and as an "ambulance" in the event of bleeding. These tablets effectively strengthen the walls of blood vessels, stop capillary and parenchymal bleeding, as well as improve microcirculation, reduce the degree of capillary permeability, and accelerate the process of blood clotting. The main active ingredient of the tablets accelerates the maturation of platelets in the bone marrow, activates the third coagulation factor in the blood vessels.

The principle of action of Dicinon tablets

The main active ingredient of Dicinon is etamsylate. This substance has a hemostatic effect, that is, it reduces or completely stops bleeding. When small vessels are damaged, the drug activates and forms thromboplastin in the blood, which is necessary to start coagulation processes.

• Thromboembolism
• Hemoblastosis in children
• Acute porphyria
• Hypersensitivity to sodium sulfide and other tablet ingredients
• Intolerance to carbohydrates, be sure to consult your doctor.

Tablets do not have any effect on a person's reaction, so there are no contraindications for those people who drive vehicles or work with various mechanisms.

Side effects of the drug

The most common negative ones are:

• dizzy
• pain in the head
• nausea
• redness of the face
• loss of sensation in the legs
• skin rashes
• stomach ache

In addition, severe leukopenia appears in those who suffer from acute lymphatic and myeloid leukemia when they are prescribed a drug to prevent bleeding. All of the above effects occur in a non-severe form and are observed quite rarely.

So, Dicinon tablets are prescribed for both adults and children. The medicine reduces internal and external bleeding, accelerates the process of blood clotting.

Feb 24, 2017 Violetta Doctor

The action of the drug is based on the ability of etamsylate to create thromboplastin. Dicynon in ampoules is used, according to the instructions for use, for bleeding and hemorrhage.

This is what genuine dicynone looks like in ampoules. Instructions for use must be included in the package.

In addition to the main ingredient, the composition of the drug includes water, sodium disulfite and bicarbonate. The solution is colorless and transparent.

The drug promotes the formation of mucopolysaccharides that protect protein fibers from damage and normalize capillary permeability. Dicinon removes excess fluid in the bloodstream of the vessel, increases the strength of capillaries, provokes the creation of platelets in the bone marrow, prolongs their existence and enhances activity.

The advantage of Dicinon is that it does not constrict blood vessels, does not increase clotting and does not provoke the formation of blood clots.

After 15 minutes after injection into the vein, the effect of the drug is manifested. The peak of exposure is noticeable an hour after the injection. The total duration of action lasts no more than 6 hours.

In a situation where the drug is injected into the muscle, the effect becomes noticeable after four hours after the injection.

Dicinon is perfectly absorbed in the body, equally distributed to organs and tissues. Practically does not react with proteins and enzymes contained in the blood. The drug is quickly excreted from the body with urine and bile.

Indications for use of the drug Dicinon in ampoules

The drug is used for the prevention and treatment of cerebral hemorrhages in stroke, trauma, capillary bleeding, as well as in:

• gynecology;
• obstetrics;
• dentistry;
• urology;
• ophthalmology;
• otorhinolaryngology.

The medication is prescribed for damage to internal organs and hemorrhages in them: spleen, kidneys or liver; with bleeding that has arisen due to a qualitative inferiority of platelets or a decrease in the number of formed elements in the blood; with slow blood clotting; with microangiopathy caused by diabetes; with hemorrhagic diathesis or vasculitis.

Dicynon in ampoules is used, according to the instructions and recommendations of physicians, in urology and gynecology for uterine dysfunction, menorrhagia, in women with intrauterine devices, metrorrhagia, endometriosis, hematuria, hemorrhage after abortion and hemorrhages inside the skull in newborns.

In dentistry, the drug is used for severe bleeding of the gums and during dental procedures and operations. In otorhinolaryngology - with epistaxis. In ophthalmology, the drug is used to prevent hemophthalmia and secondary retinal hemorrhages, as well as to reduce blood loss during ophthalmic surgery.

Dicinon is also used for bleeding due to Wergolf's disease.

Dicinon acts as an angioprotector in varicose syndromes, hepatitis, cirrhosis of the liver, radiation and chemotherapy, retinopathy, atherosclerosis, nephritis, angiopathy, toxic effects on blood vessels in viral and microbial infections.

Who should not use Dicinon: contraindications

Injections are effective if Dicinon is used in ampoules. But the instructions for use prohibit the use of the drug if the history contains:

• asthma;
• vascular thrombosis;
• thromboembolism;
• acute form of porphyria;
• intolerance or hypersensitivity to any components of the drug;
• tumors (both in children and adults).

Dicinon can not be used for leukemia, osteosarcoma and glucose-lactose deficiency.

Use of Dicinon during pregnancy and lactation

Avoid injections during pregnancy. Use can only be prescribed when the intended benefit to the mother outweighs the risks to the embryo.

During pregnancy, the medication is used to combat brown and spotting discharges, detachment of the placenta and the outer shell of the embryo.

In a situation where the use of the drug is prescribed during lactation, the introduction of Dicinon is possible, but subject to the refusal of lactation. This is due to the fact that the medicinal substance of the drug, passing through all the barriers, enters breast milk, and with it into the body of the baby.

How to use the drug Dicinon

Injections of the drug are made into the muscle or vein (only in medical institutions), also into the space surrounding the eyeball and behind the eyeball.

Also, the solution is applied to the place - a sterile cotton swab or a napkin soaked in Dicinon is applied to the wound or into the oral cavity (during dental procedures).

Instructions for use for adults

Adults are administered no more than 20 mg of the drug per 1 kg of body weight. This dose is divided into 4 times, injections are given intravenously or intramuscularly. On the recommendation of a specialist, the dosage can be increased to 750 mg of medication per day.

Instructions for use for children

Children are prescribed Dicinon in ampoules with caution. Instructions for use for children involve the introduction of no more than 10 mg (in total) per unit mass. In one day there should be 4 injections.

But usually the dosage for the child is calculated by the doctor individually.

In case of intracranial bleeding in newborn infants, drug therapy should begin no later than 2 hours after birth. Injections are given every 6 hours for four days.

Instructions for use for uterine bleeding

To prevent bleeding from the uterus, 250 mg of medication is injected into the body every 7 hours. All therapy lasts no more than ten days.

Dicynon helps fight abnormal bleeding, irregular menstruation, very heavy discharge and metrorrhagia.

Exceeding the dosage for gynecological diseases provokes a stop to menstruation and a failure of the entire menstrual cycle. The question of prescribing the drug for strong or prolonged discharge is decided solely by the doctor. With the help of the drug, you can delay the onset of menstrual flow by no more than 2 weeks.

But in this case, it is necessary to be careful about prescribing the drug, because after drug therapy the entire cycle may shift or there is a risk of hormonal disorders.

During the use of the drug to stop uterine bleeding, some side effects are more than possible. For example, heartburn, dizziness, numbness of the limbs and others.

To consolidate the achieved effect, you need to conduct a second course of Dicinon before the start of the next menstruation.

Instructions for use in surgery

In surgery, the drug is used to prevent bleeding in the intestines, lungs and other internal organs; when removing tumors.

To reduce blood loss during surgical interventions, Dicinon is administered in ampoules. Instructions for use in surgery involves the introduction of the drug 60 minutes before the intervention in the amount of two ampoules (500 mg). Then, repeated injections can be given during the operation and at its completion every 5 hours, to stop bleeding and to prevent postoperative bleeding.

It is necessary to pay attention to the fact that Dicinon, mixed with a solution of sodium chloride, must be introduced into the body immediately.

Dicynon in ampoules: side effects and complications

Before starting therapy with Dicinon, you should pay attention to the fact that the drug can provoke side effects. Often, rashes and hyperemia can appear on the skin, headaches, dizziness appear on the part of the nervous system. Problems with the digestive system may occur:

• heartburn;
• nausea;
• vomit;
• heaviness;
• pain syndromes.

In addition, Dicinon has a serious effect on the cardiovascular, lymphatic and circulatory systems. The action is manifested in a decrease in blood pressure, in the occurrence of thromboembolism, thrombocytopenia, neutropenia, agranulocytosis.

Effects on the immune system are very rare. But it can manifest itself in the form of allergic reactions, itching, swelling and redness.

Side effects may include fever and asthenia. Also, sometimes redness and itching appear at the injection site.

Special instructions for the use of the drug Dicinon

Dicinon solution in ampoules is intended for use only in clinics and other medical institutions.

The use of the drug is possible in individual doses calculated for the patient personally by the doctor.

Care must be taken when prescribing the drug to patients who have had thrombosis and bleeding caused by taking anticoagulants. It is worth refusing to use the medication in case of intolerance or excessive sensitivity to etamsylate.

If hemorrhagic complications are observed due to anticoagulant therapy, then antidotes should be used.

The drug can be taken prophylactically. For these purposes, it is either injected into a vein or taken orally.

Dicinon is not compatible with other medicines in the same container, but it is possible to prescribe it together with other medicines of different action groups.

The drug must be stored in a dark, cool place with an air temperature of no more than 25 ° C.

Instructions for use states that the total period of use of Dicinon in ampoules should not be more than ten days. In diseases of the circulatory system and lesions of the blood vessels, the course of the drug should be no more than 2 weeks.

If there is a need to carry out Dicinon therapy for longer than the recommended period, then the total dosage should be gradually reduced.

Nowadays, medicine has come a long way. Medicines have been created that stop even severe bleeding, for example, Dicinon in ampoules. Using the drug according to the instructions, you can only benefit the body.

Video clips: Dicyonon what it is and how to use it

Dicynon in ampoules. Instructions for use, reviews, indications:

What is dicynone:

INSTRUCTIONS
on the use of a medicinal product for medical use

Read this leaflet carefully before you start using this medicine. Keep the instructions, they may need to be repeated. If you have any questions, please contact your doctor.
This medicine has been prescribed for you personally and should not be shared with others as it may harm them even if they have the same symptoms as you.

Registration number:

Trade name of the drug:

International non-proprietary name:

etamsylate.

Dosage form:

tablets.

Compound

1 tablet contains: Active substance: etamsylate - 250.0 mg.
Excipients: citric acid anhydrous 12.5 mg; corn starch 65.0 mg; povidone K25 10.0 mg; magnesium stearate 2.0 mg; lactose 60.5 mg.

Description

Round biconvex tablets of white or almost white color.

Pharmacotherapeutic group

ATX Code: B02BX01

Pharmacological properties

Indications for use

Contraindications

Carefully

Thrombosis, thromboembolism in history; bleeding on the background of an overdose of anticoagulants, impaired liver and kidney function (no clinical experience of use).

Use during pregnancy and during breastfeeding

Dosage and administration

inside.
The optimal daily dose of etamsylate for adults is 10-20 mg / kg of body weight per day, divided into 3-4 doses. In most cases, a single dose is 250-500 mg (1-2 tablets), if necessary, a single dose can be increased to 750 mg (3 tablets).
Adults and teenagers (over 12 years old, weighing more than 40 kg)
In the preoperative period 250-500 mg (1-2 tablets) 1 hour before surgery.
In the postoperative period 250-500 mg (1-2 tablets) every 4-6 hours until the risk of bleeding disappears.
To stop bleeding 500 mg (2 tablets) every 8-12 hours (1000-1500 mg per day) with food or some water.
In the treatment of metro- and menorrhagia 500 mg (2 tablets) 3 times a day (1500 mg per day) for 5-10 days.
Children from 3 to 12 years old
Half dose for adults.

Side effect

According to the World Health Organization (WHO), undesirable effects are classified according to their frequency of development as follows: often (> 1/100,<1/10), нечасто (>1/1000, <1/100), редко (>1/10000, <1/1000) и очень редко (<1/10000), включая отдельные сообщения.
From the digestive system
often: nausea, diarrhea, discomfort in the epigastric region.
From the skin and subcutaneous tissues
often: skin rash;
frequency unknown: hyperemia of the skin.
From the side of the nervous system
often: headache;
frequency unknown: dizziness, paresthesia of the lower extremities.
From the side of the cardiovascular system
very rarely: thromboembolism;
frequency unknown: pronounced decrease in blood pressure.
From the blood and lymphatic system
very rarely: agranulocytosis, neutropenia, thrombocytopenia.
From the side of the musculoskeletal system
rarely: arthralgia.
From the side of the immune system
very rarely: allergic reactions.
Other
often: asthenia;
very rarely: fever.
Side effects that occur during treatment are usually reversible when the drug is discontinued.
In the event of skin reactions or fever, it is necessary to stop therapy and inform the attending physician, as this may be a manifestation of a hypersensitivity reaction.

Overdose

Interaction with other drugs

There are still no data on the interaction of etamsylate with other drugs.
Perhaps a combination with aminocaproic acid and menadione sodium bisulfite.

special instructions

Influence on the ability to concentrate

No special precautions required.

Release form

Storage conditions

Store at a temperature not exceeding 25°C, in a dry, dark place.
Keep out of the reach of children.

Best before date

5 years.
Do not use after the expiration date.

Holiday conditions

On prescription.

Manufacturer