Berlition 300 injections. Berlition is a highly effective drug in the treatment of osteochondrosis. Use in children

Berlition 600 mg tablets are close to B-vitamins in their bioactivity. The drug contributes to the normalization of metabolic processes and improves the trophism of the nervous tissue. It is also effective as a hepatoprotector and in the complex treatment of neuropathies of various origins.

The INN of the drug is Thioctic acid.

ATX

The drug belongs to the pharmacological group of metabolic and hepatoprotective agents with the ATC code A16AX01.

Compound

The active component of Berlition is α-lipoic (thioctic) acid, which is also called thioctacid. The oral form of the drug is presented in capsules of 300 and 600 mg and tablets in a shell with an active substance content of 300 mg. An additional composition of the tableted product is represented by lactose monohydrate, colloidal silicon dioxide, microcellulose, povidone, sodium croscarmellose, magnesium stearate. The film coating is formed by hypromellose, titanium dioxide, mineral oil, sodium lauryl sulfate and dyes E110 and E171.

Yellowish tablets have a rounded shape and a central risk on one side. They are packaged in 10 pcs. in blisters, which are laid out in 3 pcs. into cardboard boxes. The soft shell of the capsules has a pink color. It is filled with a yellow pasty substance. Capsules of 15 pcs. distributed in cellular packaging. 1 or 2 blister sheets and an instruction leaflet are placed in cardboard packs.

Also, the drug is available in the form of a concentrate. A sterile solution is prepared from it, intended for infusion. The active substance here is represented by ethylenediamine salt in an amount equivalent to 600 mg of lipoic acid. Water for injection is used as a solvent. The liquid is poured into ampoules of 12 or 24 ml. In the package they can be 10, 20 or 30 pcs.

pharmachologic effect

A-lipoic acid is a vitamin-like compound similar to B-vitamins. It has a direct and indirect effect on free radicals, showing antioxidant properties, and also activates the work of other antioxidants. This allows protecting nerve endings from damage, inhibiting the process of glycosylation of protein structures in diabetics, and activating microcirculation and endoneural circulation.

Thioctacid is a coenzyme of multimolecular enzyme complexes of mitochondria and takes part in the decarboxylation reactions of alpha-keto acids. It also reduces the amount of glucose in the blood plasma, increases the concentration of glycogen in the structures of the liver, increases the body's susceptibility to the action of insulin, is involved in lipid-carbohydrate metabolism and contributes to the normalization of cholesterol levels.

Under its influence, cell membranes are restored, cell conductivity increases, the functioning of the peripheral nervous system improves, alternative glucose metabolism increases, which is especially important for patients with diabetes mellitus. Thioctic acid has a beneficial effect on hepatocytes, protecting them from the damaging effects of free radicals and toxic substances, including ethanol metabolites.

Due to its pharmacological characteristics, thioctacid has the following effects on the body:

• hypolipidemic;
• hypoglycemic;
• hepatoprotective;
• neurotrophic;
• detoxification;
• antioxidant.

Pharmacokinetics

The drug after oral administration for 0.5-1 hour is absorbed into the blood almost completely. The fullness of the stomach inhibits the process of its absorption. It is rapidly distributed throughout the tissues. The bioavailability of lipoic acid ranges from 30-60% due to the "first pass" phenomenon. Its metabolism is carried out mainly by conjugation and oxidation. Up to 90% of the drug, mainly in the form of metabolites, is excreted in the urine 40-100 minutes after ingestion.

Indications for use of tablets Berlition 600

The drug is most often prescribed for polyneuropathy, which manifests itself in the form of pain, burning, temporary loss of sensation in the limbs. This pathology can be caused by diabetes, alcohol abuse, bacterial or viral infection (as a complication, including after the flu). The drug is also used in complex treatment in the presence of:

• hyperlipidemia;
• fatty degeneration of the liver;
• fibrosis or cirrhosis;
• hepatitis A or chronic form of the disease (in the absence of severe jaundice);
• poisoning with poisonous mushrooms or heavy metals;
• atherosclerosis of the coronary vessels.

In some cases, it is possible to use Berlition as a prophylactic.

Contraindications

The drug is not prescribed with increased susceptibility to the action of thioctic acid and with intolerance to auxiliary components. Other contraindications:

• pregnancy;
• lactation without interruption of breastfeeding;
• age up to 18 years.

For patients with diabetes, the drug should be used with caution due to the risk of hypoglycemia.

How to take Berlition 600 tablets

Oral administration of the drug is carried out on an empty stomach. Tablets should be swallowed without chewing and drinking the necessary amount of water. You should not eat immediately after this, you must wait at least 30 minutes. The optimal dosage is prescribed by the attending physician.

Adults

The daily dose of the drug may vary depending on the severity of the disease. It is taken orally in full at one time, preferably before breakfast, sometimes a 2-time intake is allowed. Most often, a long course of treatment is required.

The solution must be administered drip. After 2-4 weeks, treatment is continued with tablets or capsules.

children

Oral forms of the drug are not prescribed for children and adolescents. Although there are isolated cases of their effective use for the treatment of thyroid pathologies after differentiation with rickets, Down's syndrome and other abnormalities.

With diabetes

In the treatment of diabetic polyneuropathy, it is important to maintain the concentration of sugar in the blood at the proper level. It may be necessary to adjust the doses of hypoglycemic agents taken by the patient.

Side effects of Berlition 600 tablets

When taking the drug orally, various undesirable reactions may appear:

1. Nausea, vomiting.
2. Taste anomalies.
3. Digestive disorders.
4. Pain in the abdomen.
5. Hyperhidrosis.
6. Purpura.
7. Hypoglycemia.

Hematopoietic organs

Thrombocytopenia is possible, although this is more common when the drug is administered intravenously.

central nervous system

There may be headaches, a feeling of heaviness in the head, convulsions, dizziness, impaired visual function (double vision).

allergies

Allergic symptoms are manifested in the form of skin rashes, itching, erythema. Cases of anaphylaxis have been reported.

Influence on the ability to control mechanisms

There are no special data. Given the possibility of dizziness, convulsions and signs of hypoglycemia, care should be taken when driving a car or when working with potentially dangerous mechanisms.

special instructions

Continuous monitoring of the glycemic index in diabetics is required. During treatment and in the intervals between therapeutic courses, alcohol should be completely abandoned and alcohol-containing medicinal formulations should not be taken orally.

Use during pregnancy and lactation

It is not recommended to take the drug at the stage of bearing a child. At the time of treatment, mothers should stop natural feeding, because there is no data on whether thioctacid penetrates into breast milk and what effect it has on the child's body.

Overdose

If the permissible doses are exceeded, headache, nausea, and vomiting develop. Convulsive manifestations, lactic acidosis, clotting disorders are possible.

Diabetic patients may fall into a hypoglycemic coma.

If alarming symptoms are detected, one should provoke an attack of vomiting, take a sorbent and seek medical help. Treatment is symptomatic.

Interaction with other drugs

The action of Berlition is weakened in the presence of ethanol and its decay products.

Due to the ability of lipoic acid to create complex compounds, this medicine is not taken together with components such as:

• magnesium or iron preparations;
• Ringer's solution;
• solutions of fructose, glucose, dextrose;
• milk products.

Berlition enhances the action of insulin, oral hypoglycemic drugs, and carnitine. The joint use of the drug in question with Cisplatin weakens the effectiveness of the latter.

The complex therapy of osteochondrosis often includes drugs that enhance the restorative effect,. They increase blood flow, restore neurovascular activity, normalize the course of energy processes in nerve tissues.

Such funds improve the cellular nutrition of neurons, due to which it has a restorative effect on all processes occurring in cells, and helps to preserve the functionality and structural structure of organs or tissues. Berlition belongs to such medicines.

The therapeutic effect of Berlition

Berlition is a drug of the antioxidant and hepatoprotective group, which also has hypoglycemic and hypolipidemic properties, which are to reduce glucose levels and excess lipids in the blood.

The active substance of the drug is α-lipoic (thioctic) acid. This substance is present in almost all human organs, but its predominant amount is localized in the liver, heart and kidneys. Thioctic acid is a powerful antioxidant that helps reduce the harmful toxic effects of heavy metals, toxins and other toxic compounds. In addition, this substance protects the liver from external damaging influences, improves its activity.

Thioctic acid normalizes lipid and carbohydrate metabolism, promotes sugar reduction and weight loss. According to the biochemical action, α-lipoic acid is almost identical to B-group vitamins, it stimulates cholesterol metabolism, prevents the development of atherosclerotic deposits and promotes their resorption and removal from the body.

Under the influence of the active components of Berlition, the production of by-products of the glycosylation process is reduced. As a result, the neuro-peripheral function is significantly improved, the level of glutathione (the most powerful antioxidant produced by our body and protecting against viruses, toxic substances and various diseases) increases.

The drug activates and accelerates the processes of cellular recovery and their energy processes, has a beneficial effect on neurocellular and nerve trunk metabolism, which allows Berlition to be included in the complex therapy of osteochondrosis.

Description, release form and composition

The drug is released in the form of an infusion solution, and in tablets. The infusion concentrate is placed in ampoules of 24 ml (Berlition 600) or 12 ml (Berlition 300), the package contains 5, 10 or 20 ampoules.

The composition of the solution Berlition 300 and 600:

• Salts of thioctic acid (300 or 600 mg);
• Auxiliary components such as injection water, ethylenediamine and propylene glycol.

The tableted form of Berlition is packed in cell plates of 10 tablets, the package contains 3, 6 or 10 such plates.

The photo shows the drug Berlition 300 in tablet form

Composition of Berlition 300 and 600 tablets:

• Thioctic acid (300 or 600 mg);
• Auxiliary ingredients: colloidal silicon dioxide, magnesium stearate, povidone, croscarmellose sodium, lactose, microcrystalline cellulose.

The drug is produced by the German company Berlin-Chemie / Menarini.

Read also about how used in the treatment of joints.

Indications for use

The drug α-lipoic acid is indicated:

1. With polyneuropathies of diabetic or alcoholic origin;
2. various localizations;
3. With hepatic pathologies of various etiologies (cirrhosis, hepatitis of any origin, fatty hepatic degeneration, etc.);
4. Atherosclerotic lesions of the coronary arteries;
5. Chronic intoxication with metal salts and other toxic substances.

Contraindications

Berlition is contraindicated in cases like:

• Hypersensitivity, intolerance to thioctic acid or other components of the drug;
• Children under 18;
• The period of pregnancy or lactation;
• Galactosemia, lactose intolerance.

Side effect

In the course of clinical trials of the drug, it was found that in rare cases it can cause unwanted reactions:

1. Nausea-vomiting syndrome, heartburn;
2. Convulsive muscle contractions, taste disorders, double images in the eyes;
3. Decreased blood sugar levels and symptoms characteristic of this condition, such as dizziness, headaches and hyperhidrosis;
4. People prone to allergic manifestations may develop anaphylactic shock (in isolated clinical cases);
5. Skin itching, rash, urticaria;
6. Hemorrhagic rashes, thrombophlebitis, increased bleeding, spot hemorrhages;
7. Soreness or burning at the injection or infusion site;
8. Respiratory disorders;
9. With rapid administration, a sharp rise in intracranial pressure, accompanied by a sudden feeling of heaviness in the head.

Instructions for use and dosage of the drug

The dosage and method of taking the drug depends on the disease and the form of the drug.

Mostly injections and infusions are used in the treatment of neuropathic conditions, and tablets are prescribed in all other cases, although exceptions are possible - this is decided by the doctor.

Tablets

Berlition in tablet form is prescribed once a day, 2 tablets at a time. The drug must be swallowed whole, without damaging the integrity of the tablet. It is necessary to drink the medicine with at least half a glass of water.

Sometimes, to maintain the body after the main course, they continue to take the drug one tablet once a day. This measure serves to prevent possible relapses and exacerbations.

Ampoules 300 and 600

The solution for infusion administration is dosed depending on the specific case. The doctor himself decides what dose of the drug the patient needs on an individual basis.

Most often, a dropper with Berlition is placed with neuropathic lesions of alcoholic or diabetic origin. Although, with severe poisoning or an unconscious state, the patient is not able to take pills, then he is given an injection of Berlition 300 (an ampoule per day).

To put the system, the ampoule of the drug is diluted with saline (250 ml). It is necessary to prepare such a solution only before infusion, otherwise it will quickly lose its therapeutic effect. Moreover, sunlight should not be allowed to fall on the already prepared infusion solution, so the bottle with the drug is usually wrapped in thick paper or foil.

There are situations when it is urgent to administer the drug, but there is no solvent (saline) at hand, then the concentrate can be administered using a special perfusor and syringe.

• Attention! In the case of administration through a perfusor and syringe, the concentrate should be infused slowly at a rate of 1 ml / min. In other words, a 24 ml ampoule is injected at least 24 minutes, 12 ml - 12 minutes.

Intramuscular administration of Berlition is allowed, but only according to a certain system that prohibits the introduction of more than 2 ml of a concentrated solution into one localization, in other words, to administer a 24 ml ampoule, 12 injections must be made in different muscle areas.

Be careful when carrying out an infusion procedure, which requires compliance with certain rules. To prepare an infusion solution, it is necessary to dilute the contents of the drug ampoule (24 or 12 ml) in 250 ml of saline. In this case, the dropper should be administered slowly, not more than 1.7 ml / min. The concentrated solution can only be diluted with sterile saline. During the drip, the patient must be looked after by a health worker, since there is a risk of developing anaphylaxis.

Overdose symptoms

Practice shows that if the therapeutic dose is exceeded, patients experience the following symptoms:

• Convulsive muscle contractions;
• Death of skeletal muscle tissue;
• Turbidity in consciousness;
• Increased body acidity (acidosis);
• Nausea and vomiting manifestations, headaches;
• Excitation of psychomotor;
• Decreased bone marrow function;
• A sharp drop in glucose in the blood, up to a coma of hypoglycemic origin;
• Excessive destruction of red blood cells (abnormal hemolysis);
• Intravascular coagulability of blood;
• Insufficient functionality of several organs.

In the case of taking more than 10 g of thioctic acid, severe intoxication develops, which can be fatal.

During pregnancy

It is forbidden to use any form of the drug in the treatment of pregnant and lactating women.

Alcohol compatibility

In combination with ethyl alcohol, poisoning of the body is possible, therefore, simultaneous administration of the drug with alcohol is contraindicated.

Interaction

• Simultaneous use with ethyl alcohol is unacceptable;
• When combined with drugs that reduce glucose levels, Berlition enhances their therapeutic effect, therefore, in the treatment of diabetics, it is necessary to regularly donate blood for sugar;
• Significantly reduces the effectiveness of Cisplastin (highly toxic antitumor drug);
• Since α-lipoic acid reacts with iron, magnesium and calcium, it is allowed to take drugs with similar components and consume dairy products 7-8 hours after the use of Berlition.

Which is better, Berlition or Octolipen

Octolipen is a cheaper Russian analogue of Berlition, i.e. these drugs have an identical active ingredient.

But according to patient reviews, the Russian Octolipen is more effective than the German Berlition, and the price of our generic is much lower.

Price

Tablets Berlition 300 No. 30 - 746-864 rubles;

Berlition 600 tablets No. 30 - 1197-1232 rubles;

Berlition 300 ampoules No. 5, 12 ml - 477-595 rubles;

Berlition 600 ampoules No. 5, 24 ml - 864-976.

Drug analogues

The most famous Berlition substitutes available for sale:

• Lipamide;
• Octolipen;
• Thioctacid;
• Thiolipton;
• Lipoic acid;
• Orfadin;
• Gastricumel;
• Kuvan;
• Neurolipon etc.

Thanks

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Names, release forms and composition of Berlition

To indicate the dosage of the drug, the simplified names "Berlition 300" or "Berlition 600" are often used. The concentrate for the preparation of the solution is often referred to simply as "Berlition ampoules". Sometimes you can hear about Berlition capsules, but there is no such dosage form today, and a person means a variant of the drug for oral administration.

Berlition contains as an active ingredient alpha lipoic acid , which is also called thioctova. As auxiliary components in the concentrate for the preparation of the solution contains propylene glycol and water for injection. And Berlition tablets as auxiliary components contain the following substances:

• Microcrystalline cellulose;
• magnesium stearate;
• Croscarmellose sodium;
• Povidone;
• Silicon dioxide hydrated.

The concentrate is in hermetically sealed transparent ampoules. The concentrate itself is transparent, colored greenish-yellow. Tablets have a round, biconvex shape and are colored yellow. On one surface of the tablets there is a risk. On the break, the tablet has an uneven granular surface, painted yellow.

Therapeutic effects of Berlition

• Antioxidant action. The drug helps to destroy free radicals that damage cells, causing their premature death;
• Hepatoprotective action. Thioctic acid normalizes the liver and protects the body from the negative effects of various factors, including alcohol and drugs;
• hypolipidemic action. The drug reduces the concentration of harmful fractions of lipids in the blood;
• Hypocholesterolemic action. The drug reduces the concentration of cholesterol in the blood;
• hypoglycemic action. The drug reduces the concentration of sugar in the blood and prevents complications of diabetes mellitus;
• Detoxifying action. The drug eliminates the symptoms of intoxication.

Achieving a decrease in blood sugar concentration occurs by increasing the sensitivity of cells to insulin and reducing resistance. As a result, in diabetic patients, the deposition of glucose on the inner surface of blood vessels decreases and the intensity of glycosylation and free radical damage to nerve cells decreases. This, in turn, reduces hypoxia of nerve fibers and cells, protects them from free radicals, and improves their nutrition and functioning. As a result, neuropathy associated with excessive glycosylation of proteins is prevented in diabetic patients. That is, Berlition improves the functioning of peripheral nerves, stopping the symptoms of polyneuropathy (burning, pain, numbness, etc.).

Indications for use

• Diabetic neuropathy (impaired sensitivity and conduction of peripheral nerves against the background of glucose damage);
• Alcoholic neuropathy (impaired functioning and structure of peripheral nerves against the background of damage by alcohol metabolites);
• Hepatitis of various origins (viral, toxic, etc.);
• Fatty degeneration of the liver (hepatosis);
• Chronic intoxication (poisoning) with any substances, including salts of heavy metals;
• Atherosclerosis of the coronary vessels.

Instructions for use of the drug Berlition

Berlition tablets

In addition, Berlition tablets can be taken as part of the complex therapy of liver diseases, poisoning and atherosclerosis, one piece per day. The duration of admission is determined by the speed of recovery.

Instructions for use of Berlition in ampoules (Berlition 300 and 600)

Berlition infusions are used mainly for the treatment of neuropathies. Therapy of poisoning, atherosclerosis and liver diseases is carried out with pills. However, if a person cannot take pills, then Berlition is administered intravenously at a dosage of 300 mg per day (1 ampoule of 12 ml).

To prepare a solution for intravenous infusion, it is necessary to dilute one Berlition 12 ml or 24 ml ampoule (300 mg or 600 mg) in 250 ml of physiological saline. For the treatment of neuropathies, a solution containing 300 mg or 600 mg of Berlition is administered once a day for 2 to 4 weeks. Then they switch to taking Berlition tablets in a maintenance dosage of 300 mg per day.

A solution for intravenous administration must be prepared immediately before use, as it quickly loses its properties. The finished solution must be protected from sunlight by wrapping the container with it with foil or thick opaque paper. The diluted concentrate can be used for a maximum of 6 hours if the solution has been stored away from light.

If it is not possible to prepare a solution for infusion, then the undiluted concentrate can be administered intravenously using a syringe and perfusor. In this case, the concentrate should be administered slowly, not faster than 1 ml per minute. This means that a 12 ml ampoule should be administered for at least 12 minutes, and a 24 ml ampoule for 24 minutes, respectively.

Berlition can be administered intramuscularly at 2 ml of concentrate per injection. More than 2 ml of concentrate should not be injected into the same muscle area. This means that in order to administer 12 ml of the concentrate (1 ampoule) it will be necessary to make 6 injections in different parts of the muscle, etc.

Berlition - rules for conducting a dropper

Only sterile saline can be used as a diluent for the concentrate.

special instructions

Patients suffering from diabetes, at the beginning of treatment with Berlition, should control the concentration of glucose in the blood 1 to 3 times a day. If the concentration of glucose against the background of the use of Berlition has decreased to the lower limit of the norm, it is necessary to reduce the dosage of insulin or hypoglycemic agents.

With intravenous administration of Berlition, an allergic reaction may develop in the form of itching or malaise. In this case, it is necessary to immediately stop the introduction of the solution.

If the solution is injected too quickly, a feeling of heaviness in the head, convulsions and double vision may appear. These symptoms disappear on their own and do not require discontinuation of the drug.

During the entire course of application of Berlition, care must be taken when driving a car and work that requires a high concentration of attention.

Overdose

When taking or intravenous administration of more than 5000 mg of Berlition, an overdose may develop with severe symptoms, such as:

• Psychomotor agitation;
• Clouding of consciousness;
• convulsions;
• Acidosis;
• A sharp decrease in the concentration of glucose in the blood up to hypoglycemic coma;
• Skeletal muscle necrosis;
• DIC;
• RBC hemolysis;
• Suppression of the bone marrow;
• Failure of several organs and systems.

The use of Berlition during pregnancy and lactation

Interaction with other drugs

Due to the ability to chemically interact with metal ions, it is not recommended to take magnesium, iron or calcium preparations after taking Berlition, since their absorption will be reduced. In this case, it is recommended to take Berlition in the morning, and preparations containing metal compounds in the afternoon or evening. The same goes for dairy products that are high in calcium.

Alcoholic drinks and ethyl alcohol contained in various tinctures reduce the effectiveness of Berlition.

Berlition's concentrate is incompatible with glucose, fructose, dextrose and Ringer's solutions, since thioctic acid forms poorly soluble compounds with sugar molecules.

Berlition enhances the effect of hypoglycemic drugs and insulin, therefore, with simultaneous use, it is necessary to reduce their dosage.

Side effects of Berlition

Berlition can cause the following side effects from various organs and systems:
1. From the nervous system:

• Change or disturbance of taste;
• convulsions;
• Diplopia (feeling of double vision).

• Nausea;
• Vomit;

• The appearance of pathological forms of platelets (thrombocytopathy);
• Tendency to bleed due to platelet deformity;
• Hemorrhagic rash;
• Point hemorrhages in the skin or mucous membranes (single petechiae);

• Decreased concentration of glucose in the blood;
• Complaints associated with low blood glucose levels (dizziness, sweating, headache).

• Skin rash;
• itchy skin;
• Anaphylactic shock (isolated cases in people prone to allergic reactions).

• Burning sensation in the area of ​​​​administration of the Berlition solution;
• Burning pain at the injection site;
• Exacerbation of eczema.

• A feeling of heaviness in the head that occurs when the intravenous solution is administered too quickly due to increased intracranial pressure;
• Difficulties in breathing.

Contraindications for use

• Hypersensitivity to alpha-lipoic acid or auxiliary components of the drug;
• Age under 18;
• Breastfeeding period.

Berlition (300 and 600) - analogues

Synonyms of Berlition

• Lipamide - tablets;
• Lipoic acid - tablets and solution for intramuscular injections;
• Lipothioxon - a concentrate for the preparation of a solution for intravenous administration;
• Neurolipon - capsules and concentrate for the preparation of a solution for intravenous administration;
• Octolipen - capsules, tablets and concentrate for the preparation of a solution for intravenous administration;
• Thiogamma - tablets, solution and concentrate for infusion;
• Thioctacid 600 T - solution for intravenous administration;
• Thioctacid BV - tablets;
• Thioctic acid - tablets;
• Thiolept - tablets and solution for infusion;
• Thiolipon - a concentrate for the preparation of a solution for intravenous administration;
• Espa-Lipon - tablets and concentrate for the preparation of a solution for intravenous administration.

• Bifiform Kids - chewable tablets;
• Gastricumel - homeopathic tablets;
• Veil - capsules;
• Orfadin - capsules;
• Kuvan - tablets.

Berlition (300 and 600) - reviews

Negative reviews about Berlition are very few and are mainly due to the lack of the expected effect from it. In other words, people expected one effect, but the result turned out to be somewhat different. In such a situation, there is a strong disappointment in the drug, and people leave a negative review.

In addition, negative reviews about Berlition are left by doctors who adhere to strict adherence to the principles of evidence-based medicine. Since the clinical efficacy of Berlition has not been proven, they believe that the drug is unreasonable and completely unnecessary to prescribe for the treatment of neuropathies in diabetes mellitus and other conditions or diseases. Despite the subjective improvement in a person's condition, doctors consider Berlition completely useless and leave negative reviews about it.

Berlition or Thioctacid?

Thioctacid for intravenous administration is produced under the commercial name Thioctacid 600 T, and contains 100 mg or 600 mg of the active substance per ampoule. And Berlition for injection is available in dosages of 300 mg and 600 mg. Therefore, if it is necessary to use lipoic acid in low dosages, Thioctacid is preferable. If you need to enter 600 mg of lipoic acid, then you can choose any remedy based on personal preferences. Both Berlition and Thioctacid are also available in tablet form, so if you need to use an oral medication, you can choose any drug.

For example, Thioctacid tablets are available in a dosage of 600 mg, and Berlition - 300 mg each, so the former must be taken one per day, and the latter, respectively, two each. From the point of view of convenience, Thioctacid is preferable, but if a person is not embarrassed by the need to take two tablets at a time every day, then Berlition is also perfect for him.

In addition, there is an individual tolerance of drugs, depending on the characteristics of the body of each individual person. This means that one person tolerates Berlition better, and the other - Thioctacid. In such a situation, it is necessary to choose the drug that is best tolerated and does not cause side effects. But you can find out this only experimentally, by trying to take different drugs.

However, if the clinical symptoms are quite pronounced or the tablets do not help, then it is recommended to administer drugs containing alpha-lipoic acid intravenously. In such a situation, it is necessary to use Berlition in the form of a concentrate for the preparation of a solution for intravenous administration, or Thioctacid 600 T.

Berlition (tablets, ampoules, 300 and 600) - price

Currently, in pharmacies in Russian cities, the cost of Berlition is as follows:

• Tablets Berlition 300 mg 30 pieces - 720 - 850 rubles;
• Berlition concentrate 300 mg (12 ml) 5 ampoules - 510 - 721 rubles;
• Berlition concentrate 600 mg (24 ml) 5 ampoules - 824 - 956 rubles.

Where could I buy?

Berlition is an antioxidant and hepatoprotective drug with hypoglycemic and hypolipidemic properties. Reduces the level of glucose and excess lipids in the blood.

The active substance is α-lipoic (thioctic) acid.

Thioctic acid normalizes lipid and carbohydrate metabolism, promotes sugar reduction and weight loss. According to the biochemical action, α-lipoic acid is almost identical to B-group vitamins, it stimulates cholesterol metabolism, prevents the development of atherosclerotic deposits and promotes their resorption and removal from the body.

In people with diabetes, Berlition helps to reduce the concentration of pyruvic acid in the circulatory system. The drug prevents the deposition of dextrose in the vessels of the circulatory system, which significantly improves the overall blood flow. Stimulates the formation of glutathione. By the nature of the biochemical action, it is close to the vitamins of group B.

Alpha-lipoic acid is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability of alpha-lipoic acid tablets is 20%. The maximum concentration of the active substance in the blood plasma is observed 30 minutes after ingestion. The elimination half-life averages 25 minutes.

In the body, acid binds to metal ions, forms sparingly soluble compounds with sugar molecules. 80-90% of the active substance is excreted by the kidneys in the form of inactive metabolites, a small part of α-lipoic acid is excreted unchanged.

Released in the following dosage forms:

1. Concentrate for solution for infusion: greenish-yellow color, transparent (Berlition 300: 12 ml in dark glass ampoules, 5, 10 or 20 ampoules in cardboard trays, 1 tray in a cardboard pack;
2. Berlition 600: 24 ml in dark glass ampoules, 5 ampoules in plastic trays, 1 tray in a cardboard box);
3. Film-coated tablets: round, biconvex, scored on one side, pale yellow in color, a granular uneven surface is visible on the cross section.

During the entire course of treatment, you should refrain from drinking alcoholic beverages, as they reduce the effectiveness of the drug. When taking alcohol and high dosages of Berlition, severe poisoning can develop with a high probability of death.

Indications for use

What helps Berlition? The drug is prescribed in the following cases:

• fibrosis and cirrhosis of the liver;
• alcoholic polyneuropathy;
• chronic hepatitis;
• diabetic polyneuropathy;
• fatty degeneration of the liver;
• toxic effect of metals.

Instructions for use Berlition, dosage

Tablets and capsules are prescribed orally, they are not recommended to be chewed or crushed during use. The daily dose is taken once a day, about half an hour before the morning meal.

As a rule, the duration of therapy is long. The exact time of admission is determined individually by the attending physician. Medication dosages:

• With diabetic polyneuropathy - 1 capsule Berlition 600 per day;
• For liver diseases - 600-1200 mg of thioctic acid per day (1-2 capsules).

Berlition in the form of a concentrate for solution for infusion is used for intravenous administration. Only 0.9% sodium chloride should be used as a solvent, 250 ml of the prepared solution is injected over half an hour. Medication dosages:

• In severe form of diabetic polyneuropathy - 300-600 mg (1-2 tablets Berlition 300);
• In severe liver disease - 600-1200 mg of thioctic acid per day.

For intravenous administration (injections)

At the beginning of treatment, Berlition 600 is prescribed intravenously in a daily dose of 600 mg (1 ampoule).

Before use, the contents of 1 ampoule (24 ml) are diluted in 250 ml of 0.9% sodium chloride solution and injected intravenously, slowly, for at least 30 minutes. Due to the photosensitivity of the active substance, the solution for infusion is prepared immediately before use. The prepared solution must be protected from light exposure, for example, with aluminum foil.

The course of treatment is 2 - 4 weeks. As a follow-up maintenance therapy, oral thioctic acid is used at a daily dose of 300-600 mg.

Side effects

Appointment Berlition may be accompanied by the following side effects:

• Violation of the functions of the digestive tract: attacks of nausea, vomiting, stool disorders, manifestations of dyspepsia, changes in taste sensations;
• Violations of the functions of the central and peripheral nervous system: a feeling of heaviness in the head, double vision of objects in the eyes (diplopia), and convulsions;
• Violations of the functions of the cardiovascular system: hyperemia of the skin of the face, tachycardia, a feeling of chest tightness;
• Allergic reactions: rashes, itching, urticaria, eczema. Against the background of the introduction of a high dosage, in some cases, the development of anaphylactic shock is possible;
• Other disorders: exacerbation of symptoms of hypoglycemia and, in particular, increased sweating, increased headache, blurred vision and dizziness. Sometimes patients have difficulty breathing, symptoms of thrombocytopenia and purpura.
• At the beginning of the course of treatment, the introduction of the drug can provoke an increase in paresthesia, accompanied by a feeling of crawling on the skin.

If the solution is injected too quickly, a feeling of heaviness in the head, convulsions and double vision may appear. These symptoms disappear on their own and do not require discontinuation of the drug.

Contraindications

It is contraindicated to prescribe Berlition in the following cases:

• Any trimester of pregnancy;
• Hypersensitivity of patients to Berlition or its components;
• The period of breastfeeding;
• Simultaneous use with a solution of Dextrose;
• Use in pediatric patients;
• Simultaneous use with Ringer's solution;
• Individual intolerance to Berlition or its components.

drug interaction

The chemical interaction of thioctic acid is observed in relation to ionic complexes of metals, therefore, the effectiveness of preparations containing them, for example, Cisplatin, is reduced. For the same reason, it is not recommended to take medicines containing magnesium, calcium, iron after it. Otherwise, their digestibility is reduced.

Berlition is best taken in the morning, and preparations with metal ions - after lunch or in the evening. The same applies to dairy products, which contain large amounts of calcium. Other cases of interaction:

• the concentrate is incompatible with Ringer's solutions, dextrose, glucose, fructose due to the formation of poorly soluble sugar molecules with them;
• not used with solutions that react with disulfide bridges or SH groups;
• alpha-lipoic acid enhances the action of insulin and hypoglycemic drugs, which is why their dosage has to be reduced.

Overdose

In case of overdose, headache, nausea and vomiting may occur.

In severe cases (when taking thioctic acid at a dose of more than 80 mg / kg), the following are possible: pronounced disturbances in acid-base balance, lactic acidosis, clouding of consciousness or psychomotor agitation, disseminated intravascular coagulation syndrome, acute necrosis of skeletal muscles, generalized convulsions, hemolysis, multiple organ failure , suppression of bone marrow activity, hypoglycemia (up to the development of coma).

If severe intoxication is suspected, emergency hospitalization is recommended. First, general measures are taken that are necessary in case of accidental poisoning: induce vomiting, wash the stomach, prescribe activated charcoal, etc.

Treatment of lactic acidosis, generalized convulsions and other potentially life-threatening consequences of intoxication is symptomatic, carried out in accordance with the basic principles of modern intensive care.

There is no specific antidote. Filtration methods with forced removal of thioctic acid, hemoperfusion and hemodialysis are not effective.

Analogs Berlition, price in pharmacies

If necessary, you can replace Berlition with an analogue for the active substance - these are drugs:

1. Alpha Lipon,
2. Dialipon,
3. Tioktodar,
4. Lipothioxone,
5. Thiogamma,
6. Espa Lipon,
7. lipoic acid,
8. Thiolipon,

When choosing analogues, it is important to understand that the instructions for use of Berlition 600 \ 300, the price and reviews for drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Moscow pharmacies: Berlition tablets 300 mg 30 pcs. - 724 rubles, Berlition 300 conc.d / inf. 25mg / ml 12ml - 565 rubles.

The shelf life is 2 years for tablets, and 3 years for concentrate, at an air temperature not higher than 25C. The drug can be stored in the refrigerator, avoiding freezing.

Alpha lipoic acid, vitamin N, has similar properties to B vitamins. Alpha lipoic acid is considered one of the best natural antioxidants. It is able to protect the walls of blood vessels from the effects of free radicals. Berlition is one of the most popular drugs based on alpha-lipoic acid used for osteochondrosis. How does the drug work, what are its indications, contraindications, and how can it be replaced?

pharmachologic effect

Berlition refers to medicines, the main active ingredient of which is alpha-lipoic acid.

In pharmacology and medicine, this compound is also known as lipoic or thioctic acid.

Alpha-lipoic acid is similar to vitamins in its chemical structure and properties, it dissolves well in water and fats.

The main action of alpha lipoic acid:

1. contributes to the necessary production of enzymes in the body;
2. accelerates metabolic processes;
3. promotes the absorption and effectiveness of vitamins and antioxidants;
4. deactivates and removes free radicals:
5. protects the genetic material of DNA molecules;
6. beneficial effect on trophic processes, improving biochemical intercellular metabolism;
7. normalizes the work of neurovascular bundles;
8. regulates carbohydrate, fat balance.

Alpha lipoic acid, which is also called a universal oxidant, necessary for all cellular structures of the body. But brain, nerve and liver cells in alpha lipoic acid especially need, and suffer from a lack of this acid.

Therefore, the range of use of alpha-lipoic acid is quite wide:

• damage to nerve endings;
• diabetic neuropathy and angiopathy;
• glaucoma;
• liver disease;
• treatment of the consequences of chemical poisoning;
• as an aid in the treatment of HIV infection, diabetes.

When taken orally, the drug with alpha-lipoic acid is completely absorbed in the small intestine.

Composition and form of release of the drug

Alpha-lipoic acid as an active ingredient is presented in the drug Berlition, produced by the pharmaceutical concern Chemie (Germany).

The drug belongs to the group of hepatoprotectors, agents for the treatment and maintenance of liver functions.

According to the release form, the drug is presented:

1. In a concentrate for the preparation of a solution for injection - 12 mg ampoules, containing 300 mg alpha-lipoic acid (ED). Are packed on 5,10,15 ampoules in a cardboard box.
2. In a concentrate for the preparation of a solution for injection - 24 mg ampoules, containing the main active ingredient alpha-lipoic acid, 600 mg (ED). Packed in 5 or 10 ampoules in a cardboard box.
3. In soft gelatin capsules for oral administration - 300 mg of alpha-lipoic acid. Packed in a contour cell form and a cardboard box.

Related photo gallery:

Indications for use

The drug is prescribed as an adjuvant therapy in order to accelerate energy intercellular metabolism, improve tissue trophism, and normalize carbohydrate and lipid balance in the body.

Berlition (alpha lipoic acid) shown at:

1. atherosclerotic changes in the coronary vessels;
2. anemia;
3. hypotension;
4. with pathologies of the liver and biliary tract;
5. acute and chronic intoxications of various origins (poisoning with salts of heavy metals, poisons, alcohol);
6. polyneuropathies of the upper and lower extremities (inflammatory, toxic, allergic, traumatic, diabetic, vegetative);
7. organic disorders in the cells of the brain and spinal cord;
8. endocrine pathologies associated with metabolic disorders.

Medicines based on alpha-lipoic acid are widely used in cosmetology and endocrinology to normalize metabolic processes, to lose weight, to improve the condition of the skin.

Contraindications

The drug Berlition has its own contraindications.

With caution, under glycemic control, a drug based on lipoic acid is prescribed to patients suffering from any form of diabetes mellitus.

Berlition is not prescribed for treatment in pediatric practice, for women during pregnancy and lactation.

Drugs based on alpha-lipoic acid are prohibited and are not used for people suffering from fructose intolerance, lactose deficiency, galactosemia.

side properties

Berlition should be used only after the recommendation or prescription of a doctor.

Berlition is usually well tolerated. patients. Side effects can be in rare, extreme cases.

What symptoms might indicate side effect of the drug based on alpha lipoic acid:

• dyspepsia: nausea with vomiting, diarrhea, constipation, pain in the epigastrium;
• altered taste sensations;
• headaches, dizziness, a feeling of heaviness in the head, stupor, impaired visual function in the form of flickering flies, bifurcation of objects;
• convulsive manifestations, tremor of the limbs;
• cardiovascular disorders in the form of skin hyperemia, feelings of suffocation, tachycardia;
• allergic manifestations in the form of rashes, skin itching and urticaria.

Rarely, with the introduction of the drug Berlition in patients with neurological disorders, symptoms may worsen (increased paresthesia, sensory disturbances, painful tingling or numbness).

Dosage and overdose

The course of treatment lasts about two months

The dosage and method of administration of the drug Berlition is selected by the doctor individually.

Usually, for the treatment of polyneryropathies, Berlition is prescribed orally at a dosage of 600 IU once before the morning meal.

For severe forms of diseases, the combined use of the drug Berlition is indicated as an adjuvant therapy: injection with capsules.

Berlition's solution is administered intravenously (300 or 600 IU) for one to two weeks in the morning.

The form of the drug for injection is a concentrated substance, which is diluted with saline in an amount of 250 ml (vial) before administration.

Berlition's solution is administered intravenously by drip slowly (30-45 minutes). During the intravenous drip procedure, the vial with the dissolved drug is closed with opaque dark paper or foil.

After a course of droppers, the doctor prescribes further medication with alpha-lipoic acid (orally, capsules).

Injections of Berlition 300 IU can be administered intramuscularly for 2-4 weeks. In this case, the drug concentrate is diluted in 2 ml of saline.

The Berlition teraria course usually lasts 2 months. According to indications, a second course of treatment with a drug based on alpha-lipoic acid is prescribed after six months.

An overdose of a drug with alpha-lipoic acid can be expressed by irritation of the mucous membranes of the stomach and intestines. Overdose symptoms: abdominal pain with vomiting and diarrhea.

Berlition in the treatment of osteochondrosis

With a course of therapy with Berlition, pain and a burning sensation in the affected area of ​​the vertebra are reduced.

In the stage of chronic osteochondrosis, with the development of persistent spasm of the vertebral arteries, impaired blood circulation and innervation in the affected area, drugs that can expand blood vessels and normalize tissue trophism are necessary.

In the list of drugs with a vasodilating effect, in addition to, and, Berlition is used.

Against the background of improved microcirculation from vasodilators, Berlition enhances the recovery effect.

Thanks to this, the process of restoring damaged nerve endings and the normal, physiological passage of nerve impulses is stimulated.

Treatment with a drug based on alpha-lipoic acid normalizes and restores impaired blood circulation in the peripheral nerves, which is inevitable in osteochondrosis.

Treatment with Berlition can significantly reduce such phenomena as a burning sensation in the affected area of ​​​​the spine, crawling, numbness and pain.

Instructions for use

Only a neurologist prescribes treatment with Berlition for osteochondrosis. The dosage, course of treatment and method of administration of the drug will be prescribed taking into account the stage of osteochondrosis (acute or chronic), the severity of symptoms, comorbidities and constitutional data.

The use of tablets

Capsules of the drug are taken in the morning, on an empty stomach. In one dose, the daily dose of Berlition is taken.

Half an hour after taking the capsule, the patient can eat.

With osteochondrosis, a daily dose of 600 IU is prescribed.

In severe liver diseases, the daily dosage of the drug is doubled, and intravenous or intramuscular administration is additionally prescribed.

Application of ampoules 300 and 600

Patients in the acute stage of the disease are prescribed 300-600 units of lipoic acid (one or two ampoules of Berlition).

In addition to intravenous infusions, intramuscular injections of Berlition can be prescribed for the treatment of osteochondrosis.

In order to exclude possible complications and the development of an anaphylactic reaction, the procedures for administering the drug should be carried out only in medical institutions under the supervision of medical personnel.

Parenteral therapy with the drug is prescribed for 2-4 weeks daily. After the doctor prescribes oral administration of Berlition.

To exclude the negative consequences of treatment with Berlition, you should strictly follow the instructions, do not prescribe the drug yourself, do not exceed the recommended doses.

Berlition during pregnancy

A drug based on alpha-lipoic acid is prohibited for the treatment of women during pregnancy and lactation.

Alcohol compatibility

Berlition is not compatible with alcohol and alcohol-containing preparations. Alcohols and their metabolites neutralize the action and therapeutic activity of alpha-lipoic acid.

Price

Name of the drug	Price	Purchase	Pharmacy
Berlition 300 n30 tabl	from 808 rubles	Buy
Berlition tablets 300mg 30 pcs.	from 793 rub.	Buy
Berlition ampoules 300 units 12ml 5 pcs.	from 611 rubles	Buy
Berlition concentrate for infusions 600 units 25 mg/ml 24 ml n5 amp	from 876 rubles	Buy

Analogs substitutes

On the pharmaceutical market, Berlition's analogues are presented in a fairly wide range. In addition to tablet analogues, there are injectable analogues of the drug.

Analogues of the drug in tablets

Manufacturer: Uralbiopharm, OJSC (Russia). One film-coated tablet contains 12 and 25 mg of alpha-lipoic acid. Refers to metabolic and detoxification agents.

Producer: CJSC "Canonpharma production" (Russia). Available in two dosages: 300 and 600 IU of the main active ingredient alpha-lipoic acid.

Light yellow tablets in blisters of 10 or 15 pieces.

Manufacturer Pharmstandard-UfaVITA (Russia). Available in two dosages: 300 and 600 units of alpha-lipoic acid. It is prescribed as a hepatoprotective, hypoglycemic and neuroprotective agent.

Photos of preparations:

Producer: Pharmaceutical concern Esparma, Germany. Tablets, (200 and 600 units of alpha-lipoic acid) packed in a box of 30 pieces. According to the instructions, the drug is indicated for neuropathies, liver diseases and intoxications.

Thiogamma. Manufacturer: Pharmaceutical concern Verwag Pharma (Germany). One tablet contains 600 units of alpha-lipoic acid.

Manufacturer: Pharmaceutical concern Meda Pharma, Germany. Tablets packaged in vials of 30 pieces, at a dosage of 600 IU, with the main active ingredient alpha-lipoic acid.

Photos of analogues:

Pharmacodynamics, pharmacokinetics with side effects, dosage and method of administration are identical to Berlition 300 IU.

Analogues of the drug that are close not in composition, but in terms of the mechanism of action on the body (one pharmacological subgroup) include:

1. Gastricumel (homeopathic remedy).

Photo of preparations:

Analogues of Berlition 600

Pharmacodynamics, pharmacokinetics, side effects, dosage and method of administration are identical to Berlition 600 IU.

Photo gallery of analogues:

Which is better Octolipen or Berlition?

There is no single answer. These drugs are based on the identical active ingredient alpha-lipoic acid. But if you trust the reviews of one part of the patients, then Octolipen has a lower price, but the efficiency is higher. Another part of the patients will trust only the German Berlition.

Which drug to choose Berlition or Thiogamma?

These drugs are also synonymous drugs, analogues. It is better to give preference to the drug that is best tolerated by the patient.

Berlition or Thioctacid - which is better?

The attitude towards Thioctacid and Berlition is equivalent. Both drugs are produced by German pharmaceutical concerns with a good reputation. It is possible to conclude which one is better only experimentally, when both drugs are used for treatment.