Gastrosidin instructions for use. Registration certificate holder

• high bioavailability of the drug;
• rapid accumulation in the body and the provision of a therapeutic effect;
• delayed half-life of the drug from the body.

Flaws:

• one form of release of the drug in film-coated tablets of 20 mg;
• relatively high price of the drug.

• Film-coated tablets 40 mg, blister 10, box 3

  *** rub.

* The maximum permissible retail price of medicines is indicated, calculated in accordance with Decree of the Government of the Russian Federation No. 865 dated October 29, 2010 (For those medicines that are on the list)

Instructions for use:

Tablets are taken orally, 30 minutes before a meal or 1.5-2 hours after a meal, with a small amount of water 1-2 times a day.

For the treatment of GERD, gastritis and erosive gastroduodenitis, the drug is prescribed 20-40 mg 1-2 times a day. The maximum daily dose is 120 mg.

For the treatment of peptic ulcer of the stomach and duodenum, the drug is prescribed 40 mg 1 time per day at night or 20 mg 2 times a day (morning and evening). The maximum daily dose of the drug for this disease is 120-140 mg.

For the treatment of Zollinger-Ellison syndrome, the drug is prescribed 40 mg every 5-6 hours (4 times a day). The maximum daily dose of the drug is 240-480 mg.

To prevent bleeding from the upper gastrointestinal tract, the drug is prescribed 20 mg 1 time per day at night.

For the treatment of systemic mastocytosis and polyendocrine adenomatosis, the drug is prescribed 80 mg 3 times a day. The maximum daily dose of the drug for these diseases is 480 mg.

For the prevention of Mendelssohn's syndrome, the drug is prescribed 40 mg 1 day before surgery or, directly in the morning, on the day of surgery.

The duration of treatment is individual and is decided in each case by the attending physician.

Patients who suffer from chronic renal failure, with a sharp violation of the function of the organ, the drug is prescribed with caution in a dose not exceeding 20 mg 1 time per day.

During pregnancy and lactation, the drug is not prescribed.

Children under 18 years of age are prohibited from prescribing the drug.

comparison table

Last update of the description by the manufacturer 31.07.1998

Filterable List

Active substance:

ATX

Pharmacological group

Nosological classification (ICD-10)

Composition and form of release

1 coated tablet contains famotidine 40 mg; in a package of 3 blisters of 10 pcs.

pharmachologic effect

Blocks histamine H 2 receptors.

Pharmacokinetics

After oral administration, Cmax in plasma - after 1-3.5 hours, protein binding - 15-22%. Bioavailability - 37-45%, volume of distribution - 1.1-1.4 l / kg. Excreted from the body with urine and bile, about 25-30% of the drug is excreted in the urine unchanged. In patients with normal renal function T 1/2 - 2.5-4 hours.

Clinical pharmacology

After a single dose, the effect lasts 12 hours. It inhibits the release of hydrochloric acid in the stomach (both basal and stimulated by pentagastrin, tetragastrin or betazole). Taking 40 mg once a day Gastrosidin reduces nocturnal secretion by an average of 94%. Promotes scarring of stomach and duodenal ulcers. It does not affect the activity of the monooxygenase system of the liver and the secretion of prolactin, does not have an antiandrogenic effect.

Indications for Gastrosidin

Duodenal ulcer and benign gastric ulcer (prevention of exacerbations and treatment), pathological conditions associated with increased secretion (including Zollinger-Ellison syndrome).

Contraindications

Hypersensitivity.

Side effects

Headache, dizziness, disorientation, constipation, elevated serum transaminases.

Dosage and administration

Inside, for the treatment of peptic ulcer of the stomach and duodenum - 40 mg at night for up to 4 weeks (in the absence of effect - up to 8 weeks), for the prevention of exacerbations - 20 mg at night for 6 months, with Zollinger-Ellison syndrome - 20 mg every 6 hours (maximum daily dose - 400 mg).

Precautionary measures

Before starting treatment, you need to make sure that the ulcer is good. Pregnant women and after childbirth are prescribed in the presence of strict indications and under the supervision of a physician.

Storage conditions of the drug Gastrosidin

Keep out of the reach of children.

Shelf life of the drug Gastrosidin

Do not use after the expiry date stated on the packaging.

Synonyms of nosological groups

One tablet contains:
Active substance: 20 mg famotidine.
Excipients:
Core - lactose, corn starch, colloidal silicon dioxide, magnesium stearate
Shell - hypromellose, hydroxypropylcellulose, propylene glycol 6000, iron oxide red, iron oxide yellow, talc, titanium dioxide.

Description

Light beige, biconvex, round coated tablets with a white core.

Pharmacotherapeutic group

antiulcer agent - H2-histamine receptor blocker.

Pharmacological properties

Pharmacodynamics.

Blocker of H2-histamine receptors of the III generation. Suppresses basal and stimulated by histamine, gastrin and acetylcholine production of hydrochloric acid. Reduces the activity of pepsin. Strengthens the protective mechanisms of the gastric mucosa and promotes the healing of its damage associated with exposure to hydrochloric acid (including the cessation of gastrointestinal bleeding and scarring of stress ulcers) by increasing the formation of gastric mucus, the content of glycoproteins in it, stimulating the secretion of bicarbonate by the gastric mucosa, endogenous synthesis of prostaglandins in it and the rate of regeneration. Significantly does not change the concentration of gastrin in plasma. Weakly inhibits the cytochrome P450 oxidase system in the liver. After oral administration, the action begins after 1 hour, reaches a maximum within 3 hours. The duration of action of the drug in a single dose depends on the dose and ranges from 12 to 24 hours.

After oral administration, it is rapidly absorbed from the gastrointestinal tract. After oral administration, the maximum plasma concentration is reached within 1-3.5 hours. Bioavailability - 40-45%, increases when taken with food and decreases when taking antacids. Communication with plasma proteins - 15-20%. 30-35% of famotidine is metabolized in the liver (with the formation of S-oxide). Elimination mainly occurs through the kidneys: 27-40% of the drug is excreted in the urine unchanged. The half-life is 2.5-4 hours; in patients with creatinine clearance below 30 ml / min, it increases to 10-12 hours. In patients with severe renal insufficiency (creatinine clearance below 10 ml / min), it increases up to 20 hours. Penetrates through the placental barrier and excreted in breast milk.

Indications for use

.
Peptic ulcer of the duodenum and stomach in the acute phase, prevention of relapses.
Treatment and prevention of symptomatic gastric and duodenal ulcers (associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), stress, postoperative ulcers).
Erosive gastroduodenitis.
Functional dyspepsia associated with increased secretory function of the stomach.
Reflux esophagitis.
Zolinger-Ellison Syndrome.
Prevention of recurrent bleeding from the upper gastrointestinal tract.
Prevention of aspiration of gastric juice during general anesthesia (Mendelssohn's syndrome).

Contraindications

Pregnancy, lactation, liver failure, childhood, hypersensitivity to the components of the drug.

Carefully

Cirrhosis of the liver with a history of portosystemic encephalopathy, impaired liver function, renal failure.

Method of application and dosage

inside. With peptic ulcer of the stomach and 12 duodenal ulcer in the acute phase, symptomatic ulcers, erosive gastroduodenitis, 20 mg 2 times a day or 40 mg 1 time per day at night are usually prescribed. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks. With dyspepsia associated with increased secretory function of the stomach, 20 mg is prescribed 1-2 times a day.
In order to prevent recurrence of peptic ulcer, 20 mg is prescribed once a day at bedtime.
With reflux esophagitis - 20-40 mg 2 times a day for 6-12 weeks.
With Zolinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and may be increased to 160 mg every 6 hours.
To prevent aspiration of gastric juice during general anesthesia, 40 mg is prescribed in the evening / or in the morning before surgery. Tablets should be swallowed without chewing, drinking plenty of water.
In renal failure, if creatinine clearance is less than 30 ml / min or serum creatinine is more than 3 mg / 100 ml, the daily dose of the drug should be reduced to 20 mg.

Side effect

.
From the digestive system: dry mouth, nausea, vomiting, abdominal pain, loss of appetite, increased activity of "liver" transaminases, hepatitis, acute pancreatitis.
From the nervous system: headache, dizziness, hallucinations, confusion.
From the side of the cardiovascular system: decrease in arterial pressure, atrioventricular blockade, bradycardia.
Allergic reactions: dry skin, urticaria, pruritus, skin rash, bronchospasm, angioedema, anaphylactic shock.
From the side of the hematopoietic organs: rarely leukopenia, thrombocytopenia, in isolated cases - agranulocytosis, pancytopenia, hypoplasia, bone marrow aplasia.
From the reproductive system: with prolonged use of large doses - hyperlactinemia, gynecomastia, aminorrhea, decreased libido, impotence.
From the sense organs: paresis of accommodation, blurred vision, ringing in the ears.
Others: rarely - fever, arthralgia, myalgia.

Overdose

Symptoms: vomiting, motor agitation, tremor, lowering blood pressure, tachycardia, collapse.

Interaction with other drugs

.
Due to an increase in the pH of the contents of the stomach, while taking it, the absorption of ketoconazole and itraconazole may decrease.
With simultaneous use with antacids, sucralfate, the intensity of famotidine absorption decreases, so the interval between taking these drugs should be at least 1-2 hours.
Increased absorption of amoxicillin and clavulanic acid.
Medicines that depress the bone marrow increase the risk of developing neutropenia.

special instructions

Before starting treatment, it is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum. Famotidine, like all H2-histamine blockers, is undesirable to abruptly cancel (rebound syndrome). With long-term treatment in debilitated patients, under conditions of stress, bacterial lesions of the stomach are possible, followed by the spread of infection. H2 blockers of histamine receptors can counteract the effect of pentagastrin and histamine on the acid-forming function of the stomach, therefore, within 24 hours preceding the test, the use of H2 blockers of histamine receptors is not recommended. H2-histamine receptor blockers can suppress the skin reaction to histamine, thus leading to false negative results (it is recommended to stop using H2-histamine receptor blockers before performing diagnostic skin tests to detect an allergic skin reaction of an immediate type). During treatment, you should avoid eating foods, drinks and other drugs that can cause irritation of the gastric mucosa.

Hello!

I have had gastritis for a very long time. Sometimes it escalates, sometimes it subsides. For about half a year, I did not feel any pain in my stomach until I went on a diet. My diet is strict and after 17-18 pm I don’t eat at all. For dinner, I drink a glass of kefir.

After about two weeks, my stomach started to hurt, because. kefir is an acidic product, and in my stomach I already have high acidity. Got sick. At night I woke up from pain and I simply could not endure it. Naturally, I went to the doctor, and they prescribed me Gastrocidin . It turned out to be expensive and, moreover, it is difficult to find it in our pharmacies. Then I started looking for an analogue on the Internet and found famotidine . The active substance of Gastrosidin is famotidine, just the names are different.

I went to the pharmacy and bought my medicine it cost only 55 rubles for 30 pieces.

I started taking it as advised by the doctor and immediately after the application, the pain in the stomach simply disappeared. As a result, I drank 21 pills and completely forgot about my problems. Now I'm on a diet, the only thing is that you can't eat lemon, vinegar and other acidic foods. I drink kefir at night, but nothing hurts anymore.

Shelf life - 3 years from the date of manufacture.

Outcome . It is not necessary to buy expensive pills or medicines if there is absolutely the same thing, only many times cheaper. Famotidine for me - HUGE SALVATION! Stomach pain is very hard to endure!!

Thank you for your attention! Be healthy and good mood to you!! =)

In this article, you can read the instructions for using the drug Gastrocidin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Gastrosidin in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Gastrosidin in the presence of existing structural analogues. Use for the treatment of gastric and duodenal ulcers, reflux esophagitis, Zollinger-Ellison syndrome in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Gastrocidin- a blocker of histamine H2 receptors of the 3rd generation. Suppresses the production of hydrochloric acid, both basal and stimulated by histamine, gastrin and, to a lesser extent, acetylcholine. Simultaneously with a decrease in the production of hydrochloric acid and an increase in pH, it reduces the activity of pepsin. The duration of action after a single dose depends on the dose and ranges from 12 to 24 hours.

Compound

Famotidine + excipients.

Pharmacokinetics

After oral administration, it is rapidly, but not completely, absorbed from the gastrointestinal tract (GIT). The maximum concentration of famotidine (the active substance of the drug Gastrosidin) in blood plasma is reached after 2 hours. Its bioavailability is 40-45% and changes slightly in the presence of food. Binding to blood proteins is 15-20%. A small part of the active substance is metabolized in the liver to form famotidine S-oxide. Most of it is excreted unchanged in the urine.

Indications

• stomach ulcer, including complicated by bleeding;
• duodenal ulcer, including complicated by bleeding;
• prevention of recurrence of peptic ulcer of the stomach and duodenum;
• gastroesophageal reflux with esophagitis;
• Zollinger-Ellison syndrome and other specified disorders of the internal secretion of the pancreas;
• diseases and conditions accompanied by increased secretion of gastric juice;
• prevention of erosive and ulcerative lesions of the gastrointestinal tract while taking non-steroidal anti-inflammatory drugs (NSAIDs).

Release forms

Film-coated tablets 20 mg and 40 mg.

Instructions for use and dosing regimen

Inside, for the treatment of peptic ulcer of the stomach and duodenum - 40 mg at night for 4 weeks (if there is no effect - up to 8 weeks), for the prevention of exacerbations - 20 mg at night for 6 months, with Zollinger-Ellison syndrome - 20 mg every 6 hours (maximum daily dose - 400 mg).

Side effect

• lack of appetite;
• dry mouth;
• taste disorders;
• nausea, vomiting;
• bloating;
• diarrhea or constipation;
• cholestatic (due to stagnation of bile) jaundice;
• increased levels of transaminases in blood plasma;
• headache;
• increased fatigue;
• noise in ears;
• transient mental disorders;
• arrhythmia (violation of the heart rhythm);
• agranulocytosis, pancytopenia, leukopenia, thrombocytopenia;
• muscle pain;
• pain in the joints;
• skin itching;
• fever;
• alopecia (baldness);
• acne vulgaris;
• dry skin.

Contraindications

• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to famotidine.

Use during pregnancy and lactation

Gastrosidin is contraindicated for use during pregnancy and lactation. Famotidine is excreted in breast milk.

Use in children

Clinical experience with Gastrosidin in children is limited.

special instructions

Gastrosidin is used with caution in patients with impaired renal and hepatic function.

Before starting treatment, it is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum.

Does not change the activity of microsomal liver enzymes.

The interval between taking antacids and famotidine should be at least 1-2 hours.

drug interaction

With simultaneous use with anticoagulants, the possibility of an increase in prothrombin time and the development of bleeding is not excluded.

With the simultaneous use of Gastrosidin with antacids containing magnesium hydroxide and aluminum hydroxide, it is possible to reduce the absorption of famotidine.

With simultaneous use with itraconazole, a decrease in the concentration of itraconazole in the blood plasma and a decrease in its effectiveness are possible.

With simultaneous use with nifedipine, a case of a decrease in cardiac output and cardiac output is described, apparently due to an increase in the negative inotropic effect of nifedipine.

With simultaneous use with norfloxacin, the concentration of norfloxacin in the blood plasma decreases; with probenecid - the concentration of famotidine in the blood plasma increases.

With simultaneous use, a case of an increase in the concentration of phenytoin in the blood plasma with the risk of developing a toxic effect is described.

With simultaneous use, the bioavailability of cefpodoxime decreases, apparently due to a decrease in its solubility in the contents of the stomach with an increase in the pH of gastric juice under the influence of Gastrosidin.

With simultaneous use with cyclosporine, a slight increase in the concentration of cyclosporine in the blood plasma is possible.

Analogues of the drug Gastrosidin

Structural analogues for the active substance:

• Gasterogen;
• Kvamatel;
• Pepcidin;
• Ulfamide;
• Famopsin;
• Famosan;
• Famotel;
• Famotidine.

Analogues of the drug Gastrosidin according to the pharmacological group (H2-antihistamines):

• Aksid;
• Acidex;
• Atsilok;
• Belomet;
• Gasterogen;
• Hertocalm;
• Gistak;
• Histodil;
• Zantak;
• Zantin;
• Zoran;
• Kvamatel;
• Pepcidin;
• Pyloride;
• Primamet;
• Runiberl;
• Ranigast;
• Ranisan;
• Ranital;
• Ranitidine;
• Ranitin;
• Rantak;
• Roxane;
• Ranks;
• Simesan;
• Ulkodin;
• Ulkosan;
• Ulfamide;
• Famopsin;
• Famosan;
• Famotel;
• Famotidine;
• Cimetidine.

Feedback from a gastroenterologist

I prescribe the drug Gastrosidin to patients with gastric and duodenal ulcers in remission to prevent the development of relapses of the disease. The prophylactic course lasts six months. And in cases where patients conscientiously and regularly take pills, they manage to avoid recurrences of peptic ulcer. Important conditions are adherence to a diet and the rejection of bad habits. Patients tolerate Gastrosidin well. I do not remember that in my practice there were any serious adverse reactions during the use of this drug by patients.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.