Cofetamine instructions for use. Caffetamin (Coffetamin). Forms of release and prices for the drug, average in Russia

Cofetamine: instructions for use and reviews

Caffetamine is an anti-migraine drug.

Release form and composition

Dosage form of Cofetamine - film-coated tablets: round, biconvex; the shell is white, the core is from white to white with a creamy tint, marbling is allowed (10 tablets in a blister pack, in a carton 1 or 2 blister packs).

Active substances in 1 tablet:

  • caffeine - 100 mg;
  • ergotamine tartrate - 1 mg.

Additional components in the composition of Cofetamine:

  • auxiliary components: potato starch, talc, calcium stearate;
  • film coat: sucrose, dextrose monohydrate, potato starch, talc, calcium stearate.

Pharmacological properties

Pharmacodynamics

Caffetamine is a combination drug, the action of which is due to the properties of its constituent components.

Caffeine has a stimulating effect on the central nervous system (CNS), mainly on the cerebral cortex, vasomotor and respiratory centers, which increases physical and mental performance, reduces fatigue and drowsiness. Caffeine also increases the rate and force of heart contractions, increasing blood pressure (BP) in hypotension.

Ergotamine has a vasoconstrictive effect, its absorption is enhanced by caffeine.

Pharmacokinetics

Caffeine is rapidly and almost completely absorbed when taken orally. Communication with plasma proteins - 35%. It is almost completely metabolized. Excretion occurs mainly in the urine. The half-life is about 3.5 hours.

When taking ergotamine inside from the gastrointestinal tract, 62% of the substance is absorbed. Within 2 hours, its maximum plasma concentration is reached. Communication with plasma proteins is 98%. Ergotamine is metabolized in the liver, resulting in the formation of pharmacologically active metabolites. Excretion occurs mainly with bile, in 2 phases. The half-life for phase I is 2.7 hours, for phase II - 21 hours.

Indications for use

  • migraine;
  • arterial hypotension.

Contraindications

Absolute contraindications:

  • age up to 12 years;
  • pregnancy and lactation;
  • hypersensitivity to any component that is part of Cofetamine.

Relative contraindications:

  • panic anxiety disorder, agoraphobia;
  • sleep disorders;
  • organic diseases of the cardiovascular system (acute myocardial infarction, severe atherosclerosis, angina pectoris, paroxysmal tachycardia, frequent ventricular premature beats, obliterating diseases of peripheral vessels, arterial hypertension);
  • glaucoma;
  • kidney or liver failure;
  • elderly age.

Instructions for use of Cofetamine: method and dosage

During an attack, children over 12 years of age and adults are recommended to take 1-2 tablets of Cofetamine, then 1 pc. 2-3 times a day for several days.

The maximum single dose - 2 pcs., Daily - 4 pcs.

If you need to take the drug for longer than 7 days, you should take a break for 3-4 days.

Side effects

  • CNS: anxiety, agitation, tremor, dizziness, headache, paresthesia in the extremities, convulsions, increased reflexes, tachypnea, insomnia;
  • cardiovascular system: tachycardia, palpitations, cardialgia, increased blood pressure;
  • Gastrointestinal: diarrhea, nausea, vomiting;
  • allergic reactions: itching, swelling.

Prolonged use of Cofetamine can lead to addiction, drug dependence, weakness in the legs, myalgia, Leriche's syndrome (sharp cyanosis, lack of pulse in the legs, pain, impaired sensitivity of the distal type).

Overdose

Symptoms of an overdose of Cofetamine: nausea, vomiting, numbness of the fingers and toes, lethargy, drowsiness, epileptic seizures, stupor, coma.

special instructions

Sudden withdrawal of the drug can lead to increased CNS inhibition, increased drowsiness and fatigue.

Influence on the ability to drive vehicles and complex mechanisms

During therapy with Cofetamine, care should be taken when driving vehicles and other complex mechanisms that require quick psychomotor reactions.

Use during pregnancy and lactation

According to the instructions, Cofetamine is contraindicated during pregnancy.

If necessary, its use during lactation, breastfeeding should be discontinued.

Application in childhood

Caffetamine is contraindicated in children under 12 years of age.

For impaired renal function

Patients with impaired renal function should use the drug with caution.

In violation of liver function

Use in the elderly

Caffetamine should be used with caution in elderly patients.

drug interaction

  • preparations containing ergot alkaloids and caffeine: caffeine enhances their pharmacological action;
  • barbiturates, primidone, anticonvulsants (in particular hydantoin derivatives, especially phenytoin): risk of increased metabolism and increased clearance of caffeine;
  • cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin: the risk of reducing the metabolism of caffeine, slowing its excretion and increasing the concentration of the substance in the blood;
  • drugs that stimulate the central nervous system: the risk of its excessive stimulation;
  • mexiletine: 50% reduction in caffeine excretion;
  • caffeine: accelerated excretion of caffeine;
  • monoamine oxidase inhibitors, furazolidone, selegiline, procarbazine: the risk of developing a pronounced increase in blood pressure and dangerous arrhythmias when taken with large doses of caffeine;
  • calcium preparations: a decrease in their absorption in the gastrointestinal tract;
  • narcotic and hypnotic drugs: decrease in their action;
  • non-narcotic analgesics: enhancing their effect by increasing absorption;
  • lithium preparations: an increase in their excretion in the urine;
  • cardiac glycosides: acceleration of their absorption, increased action and increased toxicity;
  • β-blockers: risk of mutual suppression of therapeutic effects;
  • adrenergic bronchodilators: additional CNS stimulation and other additive toxic effects are possible;
  • theophylline and other xanthines: the risk of reducing their clearance and increasing the possibility of undesirable effects and toxic effects;
  • α-adrenergic stimulants, β-adrenergic blockers, serotonin agonists, nicotine: increased vasoconstrictive action of caffetamin;
  • macrolides: increased toxicity of ergotamine by reducing its hepatic clearance.

Analogues

Cofetamine's analogues are Kafergot, Nomigren, Ergofein, Ergoffin.

Terms and conditions of storage

Store in a dry place, away from light, at a temperature not exceeding 25 °C. Keep away from children.

Shelf life - 2 years.

Film-coated tablets, Tatkhimfarmpreparaty JSC

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instructions for use

Release form and composition

Coated tablets 1 tab. caffeine 100 mg ergotamine tartrate 1 mg

in blister packs or test tubes of 10 pcs.; in a carton pack 1 or 2 packs or 1 test tube.

Characteristic

Caffetamine is a combined anti-migraine drug.

Active substance

Caffeine + Ergotamine

Pharmadynamics

The effect of caffeine is associated with the vasoconstrictive effect of ergotamine and the improvement of brain functions under the influence of caffeine.

Caffeine accelerates the absorption of ergotamine and enhances the effect of ergot alkaloids in the treatment of migraine. Caffeine also causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness, fatigue. Caffeine has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, increases blood pressure during hypotension.

Instructions for use

Composition and form of release:
Caffetamin coated tablets, 10 or 20 pcs. packaged.
1 tablet Cofetamine contains: 100 mg, ergotamine tartrate 1 mg.

Properties / Action:
Caffetamine is a combined anti-migraine drug.
The effect of caffeine is associated with the vasoconstrictive effect of ergotamine and the improvement of brain functions under the influence of caffeine.
Ergotamine causes a vasoconstrictor effect.
Caffeine accelerates the absorption of ergotamine and enhances the effect of ergot alkaloids in the treatment of migraine. Caffeine also causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness, fatigue. Caffeine has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, increases blood pressure during hypotension.

Indications:

  • arterial hypotension;
  • as a means of lowering intracranial pressure in vascular, traumatic and infectious lesions of the central nervous system.

    Dosage and administration:
    Caffetamine is administered orally 1-2 tablets during a headache attack 2 times a day, then 1 tablet 2-3 times a day for several days (up to 1 month). The maximum single dose - 2 tablets, daily - 4 tablets.
    It is not recommended to use Cofetamine for a long time (to avoid the effects of ergotism): after 7 days of use, in cases requiring longer treatment, take a break (for 3-4 days).

    Overdose:
    Symptoms: anxiety, nervousness, irritability, insomnia, redness of the face, increased diuresis, nausea, vomiting, muscle twitching, tachycardia or arrhythmia, psychomotor agitation, tremor, hypertension, confusion, hyperreflexia, numbness in the fingers and toes, epileptic seizures.
    Treatment: cancellation of Cofetamine; gastric lavage, administration of activated charcoal if necessary - symptomatic therapy; beta-blockers (propranolol) prevent cardiotoxic effects and normalize blood pressure.

    Contraindications:

  • pregnancy and lactation.
    Caffetamine is used with caution (relative contraindications):
  • insomnia, sleep disturbances;
  • increased excitability;
  • elderly age.

    Use during pregnancy and lactation:
    Caffetamine is contraindicated during pregnancy and lactation.

    Side effects:
    From the nervous system: agitation, anxiety, tremor, anxiety, headache, dizziness, convulsions, paresthesia in the limbs, increased reflexes, tachypnea, insomnia; with the sudden cancellation of Cofetamine - increased inhibition of the central nervous system, increased fatigue, drowsiness.
    From the side of the cardiovascular system: palpitations, tachycardia, cardialgia, hypertension (increased blood pressure).

    Others: with prolonged use of Cofetamine - addiction, drug dependence, weakness in the legs, myalgia, Leriche's syndrome (cyanosis, lack of pulse in the lower extremities, pain, impaired sensitivity of the distal type).

    Special instructions and precautions:
    Before using Cofetamine, you should consult your doctor.
    Care must be taken to avoid an overdose of Cofetamine.
    Long-term use of caffeine is not recommended.

    Drug interaction:
    Caffetamine enhances the pharmacological action of other drugs containing ergot alkaloids and caffeine.
    With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, phenytoin), it is possible to increase metabolism and increase the clearance of caffeine.
    With the combined use of caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin, it is possible to reduce the metabolism of caffeine in the liver, slow down its excretion and increase blood concentrations.
    Caffeine is an adenosine antagonist.
    Mexiletin reduces the excretion of caffeine by up to 50%; nicotine increases the rate of caffeine elimination.
    Large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a pronounced increase in blood pressure while taking MAO inhibitors (furazolidone, procarbazine, selegiline).
    Caffeine reduces the absorption of calcium preparations (calcium gluconate, calcium carbonate, calcium and vitamin D) in the gastrointestinal tract.
    Caffetamine reduces the effect of narcotic analgesics and hypnotic drugs, increases the excretion of lithium preparations (lithium carbonate) in the urine, accelerates absorption and enhances the effect of cardiac glycosides (digoxin, celanide), increases their toxicity.
    The combined use of Cofetamine with beta-blockers (atenolol, metoprolol, nebivolol) can lead to mutual suppression of therapeutic effects; with adrenergic bronchodilators (clenbuterol, salbutamol, fenoterol) - to additional stimulation of the central nervous system and additive toxic effects.

    Storage conditions:
    List B. In a dry, dark place, at a temperature not exceeding 25°C.
    Shelf life: 2 years.
    Dispensed from pharmacies by prescription

    • Indications

    vasoparalytic form of migraine;

    arterial hypotension;

    as a means of lowering intracranial pressure in vascular, traumatic and infectious lesions of the central nervous system.

    Contraindications

    hypersensitivity to the components of Cofetamine;

    decompensated diseases of the cardiovascular system, severe hypertension or atherosclerosis;

    pregnancy;

    lactation period.

    With caution (relative contraindications):

    sleep disturbance;

    increased excitability;

    anxiety disorders (agoraphobia, panic disorder);

    organic diseases of the cardiovascular system (myocardial infarction, angina pectoris, atherosclerosis, paroxysmal tachycardia, ventricular extrasystole, arterial hypertension, obliterating diseases of peripheral vessels);

    hepatic and / or renal failure;

    glaucoma (increased intraocular pressure);

    elderly age.

    Use during pregnancy and lactation

    Caffetamine is contraindicated during pregnancy and lactation.

    Side effects

    From the nervous system: agitation, anxiety, tremor, anxiety, headache, dizziness, convulsions, paresthesia in the extremities, increased reflexes, tachypnea, insomnia; with sudden cancellation - inhibition of the central nervous system, increased fatigue, drowsiness.

    From the side of the cardiovascular system: palpitations, tachycardia, cardialgia, hypertension (increased blood pressure).

    From the digestive system: nausea, vomiting, diarrhea.

    Allergic reactions: swelling, pruritus.

    Others: with prolonged use - weakness in the legs, myalgia, Leriche's syndrome (cyanosis, lack of pulse in the lower extremities, pain, impaired sensitivity of the distal type).

    Interaction

    Enhances the effect of other products containing ergot alkaloids and caffeine.
    With the combined use of caffetamin and barbiturates, primidone, anticonvulsants - hydantoin derivatives (phenytoin), it is possible to increase metabolism and increase the clearance of caffeine.

    With the combined use of caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin, it is possible to reduce the metabolism of caffeine in the liver, slow down its excretion and increase blood concentrations.

    With the combined use of Caffetamin and agents that cause CNS stimulation, excessive stimulation of the CNS is possible.

    Caffeine is an adenosine antagonist.

    Mexiletin reduces the excretion of caffeine by up to 50%; nicotine increases the rate of caffeine elimination.

    Large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a pronounced increase in blood pressure while taking MAO inhibitors (furazolidone, procarbazine, selegiline).

    Caffeine reduces the absorption of calcium preparations (calcium gluconate, calcium carbonate, a combination of calcium with vitamin D) in the gastrointestinal tract.

    Caffetamine reduces the effect of narcotic analgesics and hypnotic drugs, increases the excretion of lithium preparations (lithium carbonate) in the urine, accelerates absorption, enhances the effect, increases their toxicity of cardiac glycosides (digoxin, celanide).

    The combined use of Cofetamine with beta-blockers (atenolol, metoprolol, nebivolol) can lead to mutual suppression of therapeutic effects; with adrenergic bronchodilators (clenbuterol, salbutamol, fenoterol) - to additional stimulation of the central nervous system and additive toxic effects.

    Caffeine may reduce the clearance of theophylline and aminophylline, increasing the possibility of additive pharmacodynamic and toxic effects.

    The vasoconstrictor effect of Cofetamine is enhanced by alpha-adrenergic stimulants, beta-blockers, serotonin agonists (including sumatriptan) and nicotine.

    Macrolides (erythromycin, spiramycin, josamycin, midecamycin, clarithromycin, azithromycin, roxithromycin) increase the toxicity of ergotamine.

    Overdose

    Symptoms: anxiety, nervousness, irritability, insomnia, redness of the face, increased diuresis, nausea, vomiting, muscle twitching, tachycardia or arrhythmia, psychomotor agitation, tremor, hypertension, confusion, hyperreflexia, numbness in the fingers and toes, epileptic seizures.

    Treatment: cancellation of Cofetamine; gastric lavage, administration of activated charcoal, if necessary, symptomatic therapy; beta-blockers (propranolol) prevent cardiotoxic effects and normalize blood pressure.

    Cofetamine (table p.o. N 10) Russia Tatkhimfarmpreparaty JSC

    HP-000269.INN Caffeine+Ergotamine&
    Brand name Caffetamin
    Registration number LS-000269
    Date of registration 29.04.2005
    Cancellation date
    Manufacturer Tatkhimfarmpreparaty JSC - Russia    Packaging:
    No. Packing ID EAN
    1 coated tablets 10 pcs., test tubes (1) - cardboard packs FSP 42-0015-5296-04 4604060011295
    2 film-coated tablets 10 pcs.
    3 film-coated tablets 10 pcs.

    INN
    Caffeine + Ergotamine
    Dosage form

    pharmachologic effect

    Combined drug. Caffeine causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness, fatigue. It has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, increases blood pressure during hypotension. Ergotamine causes a vasoconstrictor effect. Caffeine accelerates the absorption of ergotamine.
    Indications for use

    Migraine, arterial hypotension.
    Contraindications

    Hypersensitivity, pregnancy, lactation.
    Carefully

    Sleep disorders, anxiety disorders (agoraphobia, panic disorders), organic diseases of the cardiovascular system (including acute myocardial infarction, angina pectoris, severe atherosclerosis, paroxysmal tachycardia, frequent ventricular premature beats, arterial hypertension, obliterating peripheral vascular disease), hepatic and / or kidney failure, glaucoma, old age.
    Dosing regimen

    Inside, 1-2 tablets per reception during a headache attack, then 1 tablet 2-3 times a day for several days. The maximum single dose - 2 tablets, daily - 4 tablets.

    It is not recommended to use it for a long time (in order to avoid the effects of ergotism): after 7 days of use, in cases requiring longer treatment, take a break (for 3-4 days).
    Side effect

    From the nervous system: agitation, anxiety, tremor, anxiety, headache, dizziness, convulsions, paresthesia in the limbs, increased reflexes, tachypnea, insomnia; with sudden cancellation - increased inhibition of the central nervous system, increased fatigue, drowsiness.

    From the CCC: palpitations, tachycardia, cardialgia, increased blood pressure.

    From the digestive system: nausea, vomiting, diarrhea.

    Allergic reactions: swelling, pruritus.

    Others: with prolonged use - addiction, drug dependence, weakness in the legs, myalgia, Leriche's syndrome (sharp cyanosis, lack of pulse in the lower extremities, pain, impaired sensitivity of the distal type).
    Overdose

    Symptoms: increased severity of side effects, incl. nausea, vomiting, numbness in the fingers and toes, lethargy, drowsiness, epileptic seizures, stupor, coma.

    Treatment: gastric lavage, activated charcoal, if necessary, symptomatic therapy.
    Interaction

    Enhances the pharmacological action of other drugs containing ergot alkaloids and caffeine.

    Caffeine is an adenosine antagonist (large doses of adenosine may be required).

    With the combined use of caffeine and barbiturates, primidone, anticonvulsant drugs (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase clearance of caffeine; cimetidine, oral contraceptive drugs, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its excretion and increasing the concentration in the blood).

    CNS Stimulators - Excessive stimulation of the CNS is possible.

    Mexiletin reduces the excretion of caffeine by up to 50%; nicotine increases the rate of caffeine elimination.

    MAO inhibitors, furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a pronounced increase in blood pressure.

    Caffeine reduces the absorption of Ca2+ drugs in the gastrointestinal tract.

    Reduces the effect of narcotic analgesics and sleeping pills; increases - non-narcotic analgesics (increased absorption).

    Increases the excretion of Li + drugs in the urine.

    Accelerates absorption and enhances the action of cardiac glycosides, increases their toxicity.

    The combined use of caffeine with beta-blockers and can lead to mutual suppression of therapeutic effects; with adrenergic bronchodilator drugs - to additional stimulation of the central nervous system and other additive toxic effects.

    Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the possibility of additive pharmacodynamic and toxic effects.

    The vasoconstrictor effect of the drug is enhanced by alpha-adrenergic stimulants, beta-blockers, serotonin agonists (including sumatriptan) and nicotine. Macrolides increase ergotamine toxicity (decreased hepatic clearance of caffeine)

    Active substances: caffeine - 100 mg and ergotamine tartrate - 1 mg;
    Excipients: excipients: potato starch, talc, stearic acid, sucrose, dextrose.

    Description

    Film-coated tablets, white, biconvex shape. On the cross section, two layers are visible: the shell is white, the core is white or white with a creamy tint.

    Pharmacotherapeutic group

    Anti-migraine agent.

    PHARMACOLOGICAL PROPERTIES

    Combined drug. Caffeine causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness, fatigue. It has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, increases blood pressure during hypotension. Ergotamine causes a vasoconstrictor effect. Caffeine accelerates the absorption of ergotamine.

    Pharmacokinetics

    After oral administration, about 62% of ergotamine is absorbed in the gastrointestinal tract.
    The maximum plasma concentration is reached 2 hours after ingestion. Plasma protein binding - 98%. Ergotamine is metabolized in the liver to form pharmacologically active metabolites. Ergotamine is excreted mainly in the bile both unchanged and as metabolites. Elimination is biphasic, with half-lives of 2.7 hours and 21 hours for phases I and II, respectively.
    After taking the drug inside, caffeine is absorbed quickly and almost completely. Plasma protein binding is 35%. Caffeine is almost completely metabolized in the body. Metabolites are excreted mainly in the urine. The half-life is about 3.5 hours.

    Indications for use

    Migraine, headache on the background of arterial hypotension.

    Contraindications

    Individual intolerance to the components of the drug, pregnancy, lactation.
    With caution - sleep disturbances, anxiety disorders, organic diseases of the cardiovascular system (including acute myocardial infarction, angina pectoris, severe atherosclerosis, paroxysmal tachycardia, frequent ventricular premature beats, arterial hypertension, obliterating diseases of peripheral vessels), liver and / or kidney failure , glaucoma, old age.

    Method of application and dosage

    Inside, 1-2 tablets during a headache attack, then 1 tablet 2-3 times a day for several days. The maximum single dose is 2 tablets, the daily dose is 4 tablets.
    It is not recommended to use it for a long time (in order to avoid the phenomenon of ergotism): after 7 days of use, in cases requiring longer treatment, take a break (for 3-4 days).

    Side effect

    From the nervous system: agitation, anxiety, tremor, anxiety, headache, dizziness, convulsions, paresthesia in the extremities, increased tendon reflexes, tachypnea, insomnia; with sudden cancellation - increased inhibition of the central nervous system, increased fatigue, drowsiness.
    From the side of the cardiovascular system: tachycardia, cardialgia, increased blood pressure.
    From the digestive system: nausea, vomiting, diarrhea.
    Allergic reactions: swelling, pruritus.
    Others: with prolonged use - addiction, drug dependence, weakness in the legs, myalgia, Leriche's syndrome (sharp cyanosis, lack of pulse in the lower extremities, pain, impaired sensitivity of the distal type).

    Overdose

    Symptoms: increased severity of side effects, including nausea, vomiting, numbness of the fingers and toes, lethargy, drowsiness, epileptic seizures, stupor, coma. Treatment: gastric lavage, activated charcoal, if necessary, symptomatic therapy.

    Interaction with other drugs

    Enhances the pharmacological action of drugs containing ergot alkaloids and caffeine.
    Caffeine is an adenosine antagonist (large doses of adenosine may be required).
    With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase clearance of caffeine; cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its release and increasing the concentration in the blood).
    Central Nervous System Stimulants - Excessive stimulation of the central nervous system is possible.
    Meksiletin - reduces the release of caffeine up to 50%; nicotine - increases the rate of excretion of caffeine.
    MAO inhibitors, furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a pronounced increase in blood pressure.
    Caffeine reduces the absorption of calcium preparations in the gastrointestinal tract. Reduces the effect of narcotic and hypnotic drugs; increases - non-narcotic analgesics (increased absorption). Increases the excretion of lithium preparations in the urine.
    Accelerates absorption and enhances the action of cardiac glycosides, increases their toxicity.
    The combined use of caffeine with beta-blockers can lead to mutual suppression of therapeutic effects: with adrenergic bronchodilators - additional stimulation of the central nervous system and other additive toxic effects.
    Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the possibility of additive pharmacodynamic and toxic effects. The vasoconstrictor effect of the drug is enhanced by alpha-adrenergic stimulants, beta-blockers, serotonin agonists (including sumatriptan) and nicotine. Macrolides increase ergotamine toxicity (decreased hepatic clearance of caffeine).

    Registration number: LS-000269

    Trade name of the drug: Caffetamin.

    Dosage form: coated tablets.

    Compound:
    Active substances: caffeine - 100 mg and ergotamine tartrate - 1 mg;
    Excipients: excipients: potato starch, talc, stearic acid, sucrose, dextrose.

    Description: Coated tablets, white, biconvex shape. On the cross section, two layers are visible: the shell is white, the core is white or white with a creamy tint.

    Pharmacotherapeutic group: Anti-migraine agent.
    ATX Code N02CA52

    PHARMACOLOGICAL PROPERTIES
    Combined drug. Caffeine causes stimulation of the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness, fatigue. It has a pronounced cardiotonic effect: it increases the strength and frequency of heart contractions, increases blood pressure during hypotension. Ergotamine causes a vasoconstrictor effect. Caffeine accelerates the absorption of ergotamine.

    Pharmacokinetics
    After oral administration, about 62% of ergotamine is absorbed in the gastrointestinal tract.
    The maximum plasma concentration is reached 2 hours after ingestion. Plasma protein binding - 98%. Ergotamine is metabolized in the liver to form pharmacologically active metabolites. Ergotamine is excreted mainly in the bile both unchanged and as metabolites. Elimination is biphasic, with half-lives of 2.7 hours and 21 hours for phases I and II, respectively.
    After taking the drug inside, caffeine is absorbed quickly and almost completely. Plasma protein binding is 35%. Caffeine is almost completely metabolized in the body. Metabolites are excreted mainly in the urine. The half-life is about 3.5 hours.

    Indications for use
    Migraine, headache on the background of arterial hypotension.

    Contraindications
    Individual intolerance to the components of the drug, pregnancy, lactation.
    With caution - sleep disturbances, anxiety disorders, organic diseases of the cardiovascular system (including acute myocardial infarction, angina pectoris, severe atherosclerosis, paroxysmal tachycardia, frequent ventricular premature beats, arterial hypertension, obliterating diseases of peripheral vessels), liver and / or kidney failure , glaucoma, old age.

    Dosage and administration
    Inside, 1-2 tablets during a headache attack, then 1 tablet 2-3 times a day for several days. The maximum single dose is 2 tablets, the daily dose is 4 tablets.
    It is not recommended to use it for a long time (in order to avoid the phenomenon of ergotism): after 7 days of use, in cases requiring longer treatment, take a break (for 3-4 days).

    Side effect
    From the side of the nervous system: agitation, anxiety, tremor, anxiety, headache, dizziness, convulsions, paresthesia in the limbs, increased tendon reflexes, tachypnea, insomnia; with sudden cancellation - increased inhibition of the central nervous system, increased fatigue, drowsiness.
    From the side of the cardiovascular system: tachycardia, cardialgia, increased blood pressure.
    From the digestive system: nausea, vomiting, diarrhea.
    allergic reactions: swelling, pruritus.
    Others: with prolonged use - addiction, drug dependence, weakness in the legs, myalgia, Leriche's syndrome (sharp cyanosis, lack of pulse in the lower extremities, pain, impaired sensitivity of the distal type).

    Overdose
    Symptoms: increased severity of side effects, including nausea, vomiting, numbness of the fingers and toes, lethargy, drowsiness, epileptic seizures, stupor, coma. Treatment: gastric lavage, activated charcoal, if necessary, symptomatic therapy.

    Interaction with other drugs
    Enhances the pharmacological action of drugs containing ergot alkaloids and caffeine.
    Caffeine is an adenosine antagonist (large doses of adenosine may be required).
    With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase clearance of caffeine; cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its release and increasing the concentration in the blood).
    Central Nervous System Stimulants - Excessive stimulation of the central nervous system is possible.
    Meksiletin - reduces the release of caffeine up to 50%; nicotine - increases the rate of excretion of caffeine.
    MAO inhibitors, furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a pronounced increase in blood pressure.
    Caffeine reduces the absorption of calcium preparations in the gastrointestinal tract. Reduces the effect of narcotic and hypnotic drugs; increases - non-narcotic analgesics (increased absorption). Increases the excretion of lithium preparations in the urine.
    Accelerates absorption and enhances the action of cardiac glycosides, increases their toxicity.
    The combined use of caffeine with beta-blockers can lead to mutual suppression of therapeutic effects: with adrenergic bronchodilators - additional stimulation of the central nervous system and other additive toxic effects.
    Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the possibility of additive pharmacodynamic and toxic effects. The vasoconstrictor effect of the drug is enhanced by alpha-adrenergic stimulants, beta-blockers, serotonin agonists (including sumatriptan) and nicotine. Macrolides increase ergotamine toxicity (decreased hepatic clearance of caffeine).

    Release form
    Film-coated tablets, 10 pieces in a glass tube or 10 pieces in a blister pack. A test tube or 1-2 contour packs together with instructions for use are placed in a pack.

    Best before date
    2 years. Do not use after the expiry date stated on the packaging.

    Storage conditions
    List B. In a dry, dark place, at a temperature not exceeding 25C °.
    Keep out of the reach of children. Terms of dispensing from pharmacies By prescription.

    Manufacturer:
    JSC "Tatkhimfarmpreparaty"
    Tatarstan, 420091, Kazan, st. Belomorskaya, 260

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