What is the effect of hydrocortisone eye ointment. Hydrocortisone - ointment for external use Hydrocortisone ophthalmic instruction

Hydrocortisone eye ointment 0.5% is used to treat eye diseases caused by inflammation or allergic reactions. The tool has a pronounced antipruritic, anti-edematous and anti-inflammatory effect. Before using hydrocortisone eye ointment, the instructions should be carefully studied.

Hydrocortisone (in the form of hydrocortisone acetate 5 mg) as part of the ointment belongs to glucocorticosteroids. The main direction of action is the elimination of edema, itching, redness and other manifestations of allergies in the eyes.

It slows down the flow of leukocytes and lymphocytes into the area of ​​inflammation, the formation of scar tissue, reduces capillary permeability, and has a pronounced anti-edematous effect.

Hydrocortisone, which is the main active component of the ointment, penetrates into the outer layer of the skin and mucous membranes, slightly into the systemic circulation, while not passing through the cornea into the eye. Due to the fact that the likelihood of the active substance entering the systemic circulation in a child is higher than in an adult, caution is required when using hydrocortisone ointment in this age group of patients.

Indications

Indications for use:

• elimination of symptoms of eye diseases that are allergic in nature (allergic conjunctivitis, blepharitis, keratitis, iridocyclitis, both in the acute and chronic stages);
• treatment of thermal and chemical eye burns;
• treatment of complications after surgery.

Dosage and method of application

Eye ointment is laid behind the lower eyelid with a thin strip from 1 to 3 times a day, depending on the severity of the disease. In some cases, a hydrocortisone suspension may be used as prescribed by a doctor. The dosage of the drug in this form is 2 drops in each eye up to 4 times a day.

The duration of the course of therapy with eye ointment should not exceed 14 days. The use of the drug for a longer period requires mandatory medical supervision.

If the patient wears contact lenses, they should be discarded for the period of treatment with the ointment.

Side effects

The occurrence of side effects, which contains instructions for use, requires immediate discontinuation of the drug and contacting a doctor for advice.

In rare cases, the use of the drug can cause contact dermatitis, eyelid eczema and dermatoconjunctivitis. Prolonged use of the drug (continuously more than 2 weeks) can lead to secondary glaucoma, and therefore systematic monitoring of intraocular pressure is necessary. For the same reason, the appointment of hydrocortisone ointment requires caution in patients suffering from glaucoma.

Long-term treatment with the drug contributes to:

• the development of glaucoma and cataracts;
• thinning of the cornea up to perforation;
• slowing down tissue regeneration;
• development of secondary bacterial and fungal infection of the eye.

Contraindications

The drug is prohibited for use when:

• inflammatory diseases of the eyes, having a bacterial or fungal nature of occurrence;
• eye tuberculosis;
• glaucoma;
• violation of the integrity of the cornea;
• vaccination.

Hydrocortisone ointment is not approved for use in children under 18 years of age. An absolute contraindication is intolerance to the components of the drug.

Pregnancy and lactation

Studies regarding the use of hydrocortisone during pregnancy and lactation at a sufficient level have not been conducted. Therefore, treatment with the drug during such periods is possible only under the supervision of a physician, provided that the benefit of therapy is higher than the potential risk to which the mother and child are exposed.

Overdose

When using an eye ointment containing hydrocortisone, in accordance with the instructions, there are no signs of an overdose. If the dosage is exceeded, then local adverse reactions are possible, which disappear after discontinuation of the drug.

Interaction with other drugs

When interacting with certain drugs with hydrocortisone, there may be a possibility of undesirable effects, so it is better to inform your doctor about the need to take the following drugs in parallel:

special instructions

Immediately after applying the ointment to the lower eyelid, vision may be lost for a short time. Therefore, for some period after the procedure, it is recommended to refrain from driving a car or working with mechanisms and equipment.

If the course of therapy includes the simultaneous use of hydrocortisone ointment and other eye preparations, then the interval between their use should not be less than 15 minutes.

The ointment is available in metal tubes.

Shelf life is 2 years from the date of issue of the drug. Storage temperature 5-15 °С.

Released without a doctor's prescription.

Analogues and price

If it is impossible to use hydrocortisone in the treatment of eye diseases, the doctor can replace it with the following drugs, which have a good therapeutic effect in eliminating the symptoms of inflammatory and allergic processes:

• eye ointment and drops Maxidex;
• drops Dexamethasone;
• ointment Tetracycline. Tetracycline, which is part of the ointment, has a pronounced antibacterial effect. Therefore, this drug for complex treatment can be prescribed by a doctor in combination with steroid drugs;
• drops of Tobrex;
• eye ointment Erythromycin.

The cost of the drug is from 60 to 100 rubles per unit.

Hydrocortisone - ointment and eye ointment is successfully used to treat skin and eye diseases and injuries, accompanied by severe tissue swelling and itching. A short course of treatment leads, as a rule, to a rapid improvement in the patient's condition. Long-term hydrocortisone ointments are not used.

Hydrocortisone - ointment for external use

1% ointment for external use hydrocortisone is available in tubes of 10 g. The active ingredient of the ointment is a semi-synthetic glucocorticosteroid (GCS) hydrocortisone acetate. When applied to the skin, hydrocortisone inhibits the release of biologically active substances responsible for the development of inflammatory and allergic processes (prostaglandins and cytokines) from blood cells. Under the influence of hydrocortisone inflammatory cell infiltrates decrease, migration of leukocytes and lymphocytes to the area of ​​inflammation is inhibited. When used in the form of short courses of treatment in limited areas of the skin, it does not cause suppression of the hypothalamic-pituitary-adrenal system.

Hydrocortisone ointment is used as part of the complex treatment of inflammatory and allergic skin diseases - atopic dermatitis (including neurodermatitis), eczema, simple and allergic dermatitis, psoriasis, photodermatosis, itching of various origins, insect bites, lichen planus. For children after two years, the ointment is used with caution no more than once a day and on a small surface.

The ointment is applied in a thin layer to the skin 2-3 times a day for one to two weeks. After that, the active ingredient of the ointment accumulates in the epidermis. Hydrocortisone is decomposed partly in the epidermis, and partly (after absorption into the blood) in the liver, excreted with the kidneys and bile.

Side effects of the ointment can manifest as redness, swelling and itching at the site of application, pustular rash (the result of a decrease in skin immunity), skin weeping. If you apply the ointment for more than two weeks, then it is possible to attach a secondary infection, the development of skin atrophy, various kinds of pigment and white spots on the skin , scars, areas of increased hairiness.

The use of the ointment is contraindicated in case of hypersensitivity of the body, children under two years of age (with itching in the anus - under the age of 12 years), infectious processes on the skin (in this case, if necessary, remove the edema, hydrocortisone ointment is combined with the use of antibacterial, antifungal and antiviral drugs ), tuberculosis, syphilis, skin tumors, the appearance of changes on the skin after vaccination. Do not apply ointment to open wounds and ulcers. With caution and only as directed by a doctor, the ointment is used during pregnancy and breastfeeding. breast, as well as diabetes and pulmonary tuberculosis.

Hydrocortisone - eye ointment

Hydrocortisone 0.5% eye ointment is a greasy, soft, homogeneous white ointment. Available in tubes of 3 g. When applied to the conjunctiva of the eye, it has anti-inflammatory, anti-allergic, anti-edematous and antipruritic effects, inhibiting the formation of biologically active substances involved in inflammatory and allergic processes that develop in the tissues of the eye after exposure to mechanical, chemical or immune factors. Hydrocortisone prevents the formation of scars at the site of injuries and diseases of the cornea.

The ointment is used for inflammatory diseases of the conjunctiva, cornea, sclera, choroid, allergic diseases of the eye and the edges of the eyelids, conditions after injuries (including burns) and eye surgeries.

Ointment in a small amount (in the form of one strip) is injected into the conjunctival sac 2-3 times a day for one to two weeks. In this case, hydrocortisone almost does not enter the intraocular fluid through the cornea, but penetrates into the surface layers of the skin and mucous membrane, partially entering the bloodstream and then decomposing in the liver. The metabolic products of hydrocortisone are excreted through the kidneys and with bile.

Hydrocortisone eye ointment is a drug that is used to treat inflammatory eye diseases. It has a pronounced anti-inflammatory and anti-allergic effect.

Release form and composition

The drug is available in the form of an eye ointment in tubes of 5 and 3 g. Instructions for use are attached to each package. The active substance is hydrocortisone acetate (0.5 g), which belongs to the pharmacological group of glucocorticosteroids. Auxiliary components include methylparaben or nipagin, medical vaseline.

pharmachologic effect

The active substance of hydrocortisone ointment has a pronounced anti-allergic and anti-inflammatory effect. It reduces inflammatory cell infiltrates, reduces the migration of lymphocytes and leukocytes to the inflammatory area.

Hydrocortisone acetate also stabilizes subcellular and cellular, including lysosomal, and mast cell membranes, reduces the binding of immunoglobulins to receptors directly on the cell surface, and inhibits the release or synthesis of cytokines (interferon, interleukins) from lymphocytes and macrophages.

Hydrocortisone acetate reduces the severity of the early immunological response, has an antimetabolic effect and inhibits the formation of connective tissue and scarring.

Pharmacokinetics

Hydrocortisone ophthalmic ointment does not penetrate well into the intraocular fluid through the orbit. It penetrates only into the epithelium of the mucous membrane and the epidermis, can be absorbed in small amounts into the systemic circulation and subsequently have a systemic effect.

The drug is metabolized in the epithelium of the mucous membrane and epidermis. In the future, a small amount of it after absorption enters the systemic circulation and is further metabolized in the liver cells. In the blood, the active substance binds to transcoritin (80%) and albumin (10%). Metabolites of the drug are excreted by the intestines and kidneys.

Indications for use

Hydrocortisone ophthalmic ointment is used for allergic eye diseases (blepharitis, eyelid dermatitis, conjunctivitis, keratoconjunctivitis), inflammatory diseases of the anterior eye in the absence of a violation of the integrity of the corneal epithelium (conjunctivitis, keratoconjunctivitis, blepharitis). Also, the drug is used for chemical and thermal eye burns (after complete healing of corneal defects).

Contraindications

Contraindications to the use of this drug include hypersensitivity to its components, the presence of purulent, viral, tuberculous, fungal eye diseases, glaucoma, trachoma. Hydrocortisone ointment is not used during the vaccination period, with violations of the integrity of the membranes of the eye, under the age of eighteen years. With caution, it is prescribed during lactation and pregnancy.

Dosage and method of application

The drug is intended for topical use only. One centimeter of eye ointment is injected into the conjunctival sac two to three times a day. The course of treatment usually does not exceed two weeks. Its duration may, in some cases, increase on the recommendations of a specialist.

Similar Effects

Sometimes the use of hydrocortisone eye ointment may be accompanied by the development of allergic reactions, burning, injection of the sclera, short-term blurred visual perception.

When using the drug for more than ten days, there may be an increase in intraocular pressure with the possible development of steroid glaucoma with direct damage to the optic nerve and partial impairment of visual fields.

Subcapsular cataracts can also develop, slowing down the healing process of wounds (in diseases that cause significant thinning of the cornea, perhaps its perforation (perforation)).

Due to the suppression of the protective reactions of the body with prolonged use of the ointment, the addition of a secondary bacterial infection may be noted. In acute diseases of the eye of a purulent nature, glucocorticosteroids can enhance or mask existing infectious processes. Also, with prolonged use of the drug, a fungal infection of the cornea can be observed.

Overdose

An overdose of hydrocortisone ophthalmic ointment is extremely rare. At the same time, there is an increase in local side effects. With the abolition of the drug, the overdose phenomena disappear on their own.

Interaction

With prolonged use of the ointment due to the absorption of the active substance into the bloodstream, there may be a decrease in the effectiveness of insulin, antihypertensive, oral hypoglycemic drugs, anticoagulants. Also characteristic is a decrease in the concentration of praziquantel and salicylates in the blood.

When used with cardiac glycosides, digitalis intoxication may occur. The simultaneous use of the ointment with silver and mercury preparations leads to mutual inactivation.

special instructions

When using this drug for more than ten days with a history of glaucoma, it is necessary to monitor intraocular pressure.

The use of hydrocortisone ophthalmic ointment during lactation and pregnancy is allowed only in cases where the therapeutic effect significantly outweighs the possible risk to the child or fetus.

In such cases, the duration of use of the drug should not exceed ten days.

International non-proprietary name

Hydrocortisone

Dosage form

Eye ointment 0.5%, 3 g

Compound

1 g of ointment contains

active substance- hydrocortisone acetate 5.0 mg,

Excipients: methyl parahydroxybenzoate, white petrolatum.

Description

White or almost white, translucent, oily mass, homogeneous.

Pharmacotherapeutic group

Drugs for the treatment of eye diseases. Glucocorticosteroids. Hydrocortisone.

ATX code S01BA02

Pharmacological properties

Pharmacokinetics

Hydrocortisone, applied topically in the treatment of eye diseases, is absorbed through the cornea into the aqueous humor of the eye, the iris, the choroid itself, the ciliary body and the retina. When using the drug in therapeutic doses, clinical symptoms associated with the systemic action of glucocorticosteroids do not appear.

Pharmacodynamics

Hydrocortisone acetate has an anti-inflammatory, anti-allergic effect. The anti-inflammatory effect is associated with inhibition of the activity of the phospholipase A2 enzyme, as a result of which the synthesis of inflammatory mediators - prostaglandins and leukotrienes involved in the exudative phase of inflammation - is inhibited. In addition, it improves microcirculation in the focus of inflammation and stabilizes cellular and subcellular (lysosomal) membranes. This prevents alteration and the spread of the inflammatory process. The antiallergic effect is associated with inhibition of the proliferation phase of T-lymphocytes (helpers) and a decrease in their effect on B-lymphocytes and the production of immunoglobulins. Reduces edema, fibrin deposition, vasodilation, leukocyte migration, blood vessel proliferation, collagen deposition and scarring.

Indications for use

Allergic eye and eyelid diseases (eyelid dermatitis, blepharitis, conjunctivitis, keratoconjunctivitis, uveitis)

Prevention and treatment of inflammation after injuries and surgery on the eyeball

Restoration of transparency of the cornea and suppression of neovascularization after keratitis, chemical and thermal burns (after complete corneal epithelization)

Dosage and administration

Apply a small amount of ointment (1-2 cm) behind the lower eyelid 2-3 times a day. In post-traumatic conditions - 1 - 2 times a day (not earlier than 7 days after injury or surgery). During the application of the eye ointment, contact of the tube with the surface of the skin or conjunctiva should be avoided. The duration of treatment should not exceed 2 weeks.

Side effects

Delayed regeneration with risk of corneal perforation

The development of infectious diseases, especially viral ones

Glaucoma, cataract, burning, exophthalmos

Trophic changes in the cornea

Infection of the sclera

Increased intraocular pressure

Contraindications

Hypersensitivity to hydrocortisone acetate or base components

Purulent, viral, tuberculosis, fungal eye diseases

Primary glaucoma

Corneal epithelial defects

Trachoma

Vaccination period

Children's age up to 2 years

Drug Interactions

The risk of developing cataracts increases with the use of antipsychotics (neuroleptics, carbutamide, azathiopride) against the background of glucocorticosteroids. Simultaneous use with anticholinergics, antihistamines, tricyclic antidepressants increases intraocular pressure.

special instructions

Do not use without interruption for more than 2 weeks. With prolonged use, the incidence of side effects increases.

Long-term use (more than 3-6 weeks), especially in predisposed patients, may cause glaucoma.

Many years of repeated courses of treatment also lead to the development of cataracts. The drug contains methyl parahydroxybenzoate, which can cause allergic reactions (possibly with delayed development). Children are more likely to develop a systemic effect than adults. Therefore, children should use the drug with caution and short courses (5-7 days).

Pregnancy and lactation

During pregnancy, the drug can be used taking into account if the intended benefit to the mother is higher than the potential threat to the fetus.

During breastfeeding, the use of the drug should be discontinued.

Features of influence on the ability to drive a vehicle and servicepotentially dangerous mechanisms.

Immediately after the use of the drug, a short-term visual impairment may occur, leading to a slowdown in mental and physical reactions. Therefore, it is not recommended to use the drug immediately before working with mechanisms and driving vehicles.

Overdose

Symptoms: with prolonged use, the incidence of side effects increases. Excessive use during the day (more than 3 times a day) or use in young children can cause a systemic effect of the steroid.

Treatment: in case of overdose, treatment is symptomatic.

Release form and packaging

3 g of the drug is placed in aluminum tubes treated with epoxy varnish, with a screw-on polyethylene cap.

1 tube, together with instructions for medical use in the state and Russian languages, is placed in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25 o C.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Terms of dispensing from pharmacies

On prescription

Manufacturer

Pharmaceutical plant Jelfa A.O.

58-500 Jelenia Gora, ul. W. Pola 21, Poland.

Registration certificate holder

OOO Valeant, Moscow, Russia

Address of the organization accepting claims from consumers on the quality of products on the territory of the Republic of Kazakhstan

Representative office of Valeant LLC in the Republic of Kazakhstan

Phone 3 111 516 Fax 3 111 517

Email [email protected]

100 g of ointment contains

active substance - hydrocortisone acetate - 0.5 g,

excipients: methyl parahydroxybenzoate, petrolatum

Description

Ointment white, white with a yellowish tinge or yellow

Pharmacotherapeutic group

Drugs for the treatment of eye diseases. Glucocorticosteroids. Hydrocortisone.

ATX code S01BA02

Pharmacological properties

Pharmacokinetics

Hydrocortisone does not penetrate well through the cornea into the intraocular fluid.

Hydrocortisone penetrates into the epidermis and epithelium of the mucous membrane, can be slightly absorbed into the systemic circulation and have a systemic effect. Hydrocortisone is metabolized directly in the epidermis and epithelium of the mucous membrane, in the future, a small amount of it after

absorption enters the general circulation and is biotransformed in the liver. In the blood, 80% binds to transcortin and 10% to albumin. Metabolites of hydrocortisone are excreted through the kidneys and intestines.

Pharmacodynamics

Hydrocortisone is a natural glucocorticosteroid. It has anti-inflammatory, anti-allergic effect. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes to the area of ​​inflammation. Stabilizes cellular and subcellular, including immunoglobulins with receptors on the cell surface and inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages. Reduces the release of arachidonic acid from phospholipids and the synthesis of its metabolites (prostaglandins, leukotrienes, thromboxane). Reduces exudative reaction, helps to reduce capillary permeability. Reduces the severity of the early immunological response. It has a catabolic effect and inhibits the development of connective tissue and scarring.

Indications for use

Allergic eye diseases (eyelid dermatitis, blepharitis, conjunctivitis and keratoconjunctivitis)

Inflammatory diseases of the eyes of the anterior part of the eye in the absence of a violation of the integrity of the corneal epithelium (blepharitis, conjunctivitis and keratoconjunctivitis)

Thermal and chemical burn (after complete epithelialization of corneal defects)

Dosage and administration

1 cm of ophthalmic ointment is injected into the conjunctival sac 2-3 times a day.

To do this, you need to open the tube, tilt your head slightly back and lay a strip of ointment behind the lower eyelid. Close your eyes carefully. Close the tube tightly after use.

During the application of the eye ointment, contact of the tube with the surface of the skin or conjunctiva should be avoided.

Side effects

Allergic reactions, burning

Injection of the sclera

short term blurred vision

With prolonged use for more than 10 days, you may experience:

Increased intraocular pressure with the possible subsequent development of steroid glaucoma with damage to the optic nerve and impaired visual fields (therefore, when using drugs containing glucocorticosteroids, intraocular pressure should be measured regularly for more than 10 days)

Posterior subcapsular cataract formation

Slowing down the healing process of wounds (in diseases that cause thinning of the cornea, its perforation is possible)

Secondary bacterial infection may occur as a result of suppression of the patient's protective reaction. In acute purulent diseases of the eye, glucocorticosteroids can mask or intensify the existing infectious process.

Fungal infection of the cornea tends to occur especially often with prolonged use of glucocorticosteroids. The appearance of non-healing ulcers on the cornea after prolonged treatment with glucocorticosteroids may indicate the development of a fungal invasion.

Contraindications

Hypersensitivity to the drug and its components

Purulent, viral, tuberculosis, fungal eye diseases

Glaucoma

Trachoma

Vaccination period

Violation of the integrity of the membranes of the eye

Children and adolescents up to 18 years of age

Drug Interactions

With prolonged use of the drug with possible resorption of the drug into the general circulation, hydrocortisone reduces the effectiveness of insulin, oral hypoglycemic drugs, antihypertensives, anticoagulants, reduces the concentration of salicylates in the blood, reduces the concentration of praziquantel in the blood serum. Increase the risk of side effects of hydrocortisone: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne); antipsychotics, carbutamide, azathioprine (cataract); anticholinergics, antihistamines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia).

When used with cardiac glycosides, digitalis intoxication may develop. Simultaneous use with lead and silver preparations leads to mutual inactivation.

special instructions

With caution: arterial hypertension, diabetes mellitus.

When used for more than 10 days and a history of open or angle-closure glaucoma, control of intraocular pressure is necessary.

After applying the ointment for 30 minutes, you must refrain from activities that require increased attention.

Shelf life after opening the tube - 1 month.

Pregnancy and lactation

Studies of the safety and efficacy of hydrocortisone in pregnant and lactating women have not been conducted. There are no accurate data on the penetration of glucocorticosteroids into breast milk when applied topically. However, the risk cannot be completely excluded. The use of hydrocortisone in pregnant and lactating women is allowed only as prescribed by the attending physician, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus and child.

Duration of application should not exceed 7-10 days.