Is it possible to give tsiprolet to dogs. Pharmacokinetics of ciprofloxacin in clinically ill dogs. An antibiotic can be harmful if given in the wrong place or at the wrong dosage.

Is it possible to give a cat ciprofloxacin if his teeth hurt.

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hello. how to give antibiotic tsiprolet to a cat. weighs 4 kg

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Can I give my 3 month old puppy ciprofloxacin tablets

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No. It is said that up to a year it is impossible!

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Our one-year-old kitten Simka has always been very neat, but when he started to shit first in the corners, and then right in front of my nose, my husband and I got worried. There was no opportunity to take him to a veterinary clinic, so I had to call a doctor at home.

The doctor made an unmistakable diagnosis - cystitis, immediately stuffed the cat with an antispasmodic and prescribed a whole range of drugs - kotervin drops, an antibiotic in injections (I don’t remember the name) and ciprofloxacin in tablets.

I was pleasantly surprised when I heard the price! Since the drug is domestic, ciprofloxacin cost 10 times cheaper than foreign analogues! I don’t remember the exact dosage, and in each case it is different, we gave the antibiotic twice a day - in the morning and in the evening. Simka did not want to chew the pill, he struggled, scratched, only her husband could feed him, pressing the finger with the pill on the root of the tongue with force.

We treated our cat, and such problems did not bother him anymore (thu-thu-thu). True, once every six months we dig him kotervin.

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Six years is considered average for a dog. The Moor has always been strong, physical activity was only a joy for the dog. His breed is: Great Dane. But now, his appetite has gone bad, just give him chicken sausage. And the Moor pisses in a thin stream.

The diagnosis is very disappointing: prostatitis. Chronic form. Prescribed ciprofloxacin tablets. The antibiotic had to be taken twice a day. Dosage 13 mg per 1 kg of dog weight. Moor's weight is 80 kg. At one time, I gave him two 500 mg tablets. Treated for five days.

Mavr felt a little better, but he eats without appetite, as before. The doctor warned that only the symptoms were removed, but the disease remained. Everything can be restarted. Now you can’t overcool, it provokes relapses.

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Clueless veterinarian. Such a disease must be treated, as in humans: to give urine and a smear from the urethra for sowing microflora and sensitivity to antibiotics. And knowing the causative agent of the disease, select the desired antibiotic and dosage. Only in this way can a chronic disease be cured and the infection completely destroyed. Otherwise, it is immune suppression, the development of candidiasis and insensitive flora, and an even greater aggravation of the disease.

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Do you know how to treat otomycosis in cats? Can someone tell me the treatment. There are smear tests

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My dog ​​had prostatitis, was treated with various antibiotics, including ciprofloxacin, but it did not help, because. There were constant relapses. Only McMirror helped. When it is given to humans, 20 out of 25 men do not relapse. We drank it for a month and forgot about prostatitis forever. Good luck to you and your dog :)

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The bored Borka, lying unusually motionless in the enclosure, forced him to invite a neighbor who works in a rural veterinary clinic. After examining the piglet, taking the "material" for analysis, the specialist promised to look tomorrow.

It turned out that a one-year-old pig fell ill with an analogue of a human disease called ureaplasmosis. Genetically, we are very similar, the doctor explained, suggesting a powerful antibiotic for treatment - Ciprofloxacin. Subsequently, such a drug met me in a regular pharmacy.

For the treatment of Borka, the pill was broken according to his weight, as recommended by a neighbor. Large pieces were crushed and added to a small portion of the feed. After feeding the medicinal volume, they waited half an hour and gave the rest. The medicine was given twice a day. The course of treatment took a couple of weeks. Of course, the first tangible results came on the fifth day. A week later, the veterinarian looked again, noting that he would have to continue the course.

The veterinarian immediately warned that an allergic or other reaction is possible. Then he urgently asked to call him. However, Borka endured the effect of "Ciprofloxacin" without complications.

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Our cat recently began to show anxiety, which we assumed that she had pain in one ear. A superficial examination did not give anything, but for the sake of prevention, we dripped "Amitrazine-plus" into the animal a couple of times. It didn't get any better. In addition, it was noticed that the cat had recently lost a tooth (she is already over ten years old). And we decided that she was worried about severe pain in her gums, because of which she could well press one ear, cover her eye on the same side, and in general - lose her appetite.

A little later, we turned to the veterinarian, and a more thorough examination showed that otitis media still occurred due to the appearance of a large accumulation of mites in the auricle. But we didn't see them! Closer to the edge of the ear, the mites gathered in a fold of cartilage, and we did not see it. And since the ear was not cleaned (they thought that if there were ticks, then they were probably few), then Amitrazine did not help at first.

The cat's ears were well cleaned (both ears), they were instilled, and a further course of treatment with Ciprofloxacin and periodic treatment of the ears with the same drops was recommended. After some time, the disease subsided.

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Ciprovet tablets contain ciprofloxacin hydrochloride as an active ingredient: tablets for cats - 15 mg / tab. and tablets for dogs - 50 mg / tab., as well as auxiliary components (lactulose, calcium stearate and polyvinylpyrrolidone).

Ciprofloxacin, which is part of the drug, belongs to the group of fluoroquinolones and has a wide spectrum of antibacterial action; active against gram-positive and gram-negative bacteria, including Echerichia coli, Salmonella spp., Shigella spp., Klebsiella spp., Enterobaster spp., Proteus spp., Yersinia spp, Haemophilus spp. Campylobaster jejuni, Bruсella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobaсterium spp., Corynebaсterium diphtheriase, Staphylococcus spp. and Streptococcus spp.

Ciprofloxacin, which is part of the drug, belongs to the group of fluoroquinolones and has a wide spectrum of antibacterial action.

Properties

The mechanism of action of ciprofloxacin is based on blocking the enzyme DNA gyrase, which affects the replication of the DNA helix in the nucleus of a bacterial cell, which leads to disruption of protein synthesis and death of the microorganism.

After oral administration, ciprofloxacin is easily absorbed in the gastrointestinal tract (mainly in the duodenum and jejunum) and distributed in the organs and tissues of the body (excluding tissues rich in fats), penetrates into the pleura, peritoneum, lymph, ocular fluid and placenta.

The maximum concentration of ciprofloxacin in the blood serum is observed after 1.5-2 hours, the therapeutic concentration is maintained for 24 hours after oral administration of the drug.

Ciprofloxacin is excreted from the body mainly unchanged and partially in the form of metabolites with urine and bile, in lactating animals also with milk.

Indications for use

Ciprovet tablets are prescribed for dogs and cats for therapeutic purposes in chronic and acute bacterial infections of the gastrointestinal tract, biliary tract, respiratory organs, genitourinary system, skin and soft tissues, bones and joints, as well as in secondary infections against the background of viral diseases, the causative agents of which susceptible to ciprofloxacin.

Dosage and method of application

Ciprovet tablets are administered to animals individually orally once a day for 3-5 days in the following doses:

• cats - 1 tablet "for cats" for every 3 kg of animal weight;
• dogs 1 tablet "for dogs" for every 10 kg of animal weight.

Side effects

As a rule, there are no side effects and complications in dogs and cats when using Ciprovet tablets in accordance with this instruction.

With increased individual sensitivity of the animal to fluoroquinolones and the appearance of side effects (refusal of food, vomiting, edema, impaired coordination of movements), the use of the drug is stopped and desensitizing therapy is carried out.

Contraindications

It is not allowed to use Ciprovet tablets in females during pregnancy and lactation, in animals with severe disorders in the development of cartilage tissue, with lesions of the nervous system accompanied by convulsions, as well as in puppies and kittens until the end of the growth period.

Ciprovet tablets should not be used simultaneously with bacteriostatic antibiotics (levomycetin, macrolides and tetracyclines), theophylline and non-steroidal anti-inflammatory drugs, as well as with drugs containing magnesium, aluminum and calcium cations, which, by binding to ciprofoxacin, prevent its adsorption.

special instructions

When working with Ciprovet tablets, you should follow the generally accepted personal hygiene and safety measures provided for medicines.

Release form

Ciprovet tablets are produced in packs of 10 pieces in blisters, packed individually in cardboard boxes along with instructions for use.

Description

Capsules hard gelatin, white, number 0.

Compound

per capsule:

active substance: ciprofloxacin (as ciprofloxacin hydrochloride) - 250 mg;

Excipients: calcium stearate (E 470), potato starch.

The composition of the hard gelatin capsule shell: gelatin, glycerin, purified water, titanium dioxide, sodium lauryl sulfate.

Pharmacotherapeutic group

Antibacterial agents for systemic use. Fluoroquinolones.

ATS code: J01MA02.

pharmachologic effect

It has an antibacterial (bactericidal) effect. It blocks DNA gyrase and prevents DNA replication, disrupts the growth and division of bacteria. Causes pronounced morphological changes (including the cell wall and membranes) and rapid death of the bacterial cell. Acts on microorganisms during growth and dormancy. Ciprofloxacin has a wide spectrum of antimicrobial activity.

Commonly sensitive pathogens:

Aerobic gram-positive microorganisms: Bacillus anthracis**.

Aerobic gram-negative microorganisms: Aeromonas spp., Brucella spp., Citrobacter koseri, Francisella tularensis, Haemophilus ducreyi, Haemophilus influenzae*, Legionella spp., Moraxella catarrhalis*, Neisseria meningitidis, Pasteurella spp., Salmonella spp.*, Shigella spp.*, Vibrio spp., Yersinia pestis.

Anaerobic microorganisms: Mobiluncus.

Other microorganisms: Chlamydia trachomatis***, Chlamydia pneumoniae***, Mycoplasma hominis***, Mycoplasma pneumoniae***.

Can acquire resistance to ciprofloxacin:

Enterococcus faecalis***, Staphylococcus spp.*#, Acinetobacter baumannii+, Burkholderia cepacia+*, Campylobacter spp.+*, Citrobacter freundii*, Enterobacter aerogenes, Enterobacter cloacae*, Escherichia coli*, Klebsiella oxytoca, Klebsiella pneumoniae*, Morganella morganii* , Neisseria gonorrhoeae*, Proteus mirabilis*, Proteus vulgaris*, Providencia spp., Pseudomonas aeruginosa*, Pseudomonas fluorescens, Serratia marcescens*, Peptostreptococcus spp., Propionibacterium acnes.

Resistant to ciprofloxacin:

Actinomyces, Enterococcus faecium, Listeria monocytogenes, Stenotrophomonas maltophilia, Mycoplasma genitalium, Ureaplasma urealitycum, anaerobic microorganisms (except for the above).

*Clinical efficacy has been demonstrated for susceptible strains for approved indications.

The frequency of resistance is 50% in one or more EU countries.

** studies were conducted on animals infected by inhalation of Bacillus anthracis spores, the early start of antibiotics avoided the development of the disease, provided that the number of spores was reduced below the level of infection. Human data are limited, recommendations for use are based on susceptibility studies. in vitro and experiments on animals. Ciprofloxacin 500 mg twice daily for 2 months is considered effective in preventing anthrax.

*** natural average sensitivity in the absence of acquired resistance mechanisms.

# Methicillin-resistant S.aureus very often exhibits co-resistance to fluoroquinolones. The percentage of resistance to methicillin is 20 - 50% among all.

Indications for use

It is used for infections caused by microorganisms sensitive to the drug:

- infections of the lower respiratory tract caused by gram-negative bacteria (pneumonia, except pneumococcal, bronchopulmonary infections in chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis);

- chronic suppurative otitis media; malignant external otitis; exacerbation of chronic sinusitis, especially caused by gram-negative bacteria;

- infections of the kidneys and urinary tract;

- infections of the skin and soft tissues caused by gram-negative bacteria;

− infections of bones and joints;

− gonococcal urethritis and cervicitis;

- epididymo-orchitis, including those caused by Neisseria gonorrhoeae;

- inflammatory diseases of the pelvic organs, including those caused by Neisseria gonorrhoeae;

In the case of the above infections of the genital tract, when a connection is suspected or proven with Neisseria gonorrhoeae, it is particularly important to obtain local information on the prevalence of ciprofloxacin resistance and confirm susceptibility through laboratory testing.

- infections of the gastrointestinal tract (eg traveler's diarrhea);

− intra-abdominal infections;

- treatment of infections in patients with neutropenia, if there is a suspicion that the fever is caused by a bacterial infection;

- prevention of infections in patients with neutropenia.

Because the application fluoroquinolones, including ciprofloxacin, was associated with serious by-products reactions (see section "Precautions"), and some patients exacerbation of chronic bronchitis, acuteWithinusitis, uncomplicated urinary tract infections tend to improve without treatment, the use of fluoroquinolones in these diseases is indicated only in the absence of other alternative therapy as a reserve drug.

Dosage and administration

The dosage is determined by the indication, severity and localization of the infection, the susceptibility of the pathogen to ciprofloxacin, the patient's kidney function.

duration. treatment depends on the severity of the disease, clinical and bacteriological response to treatment.

Treatment of infections caused by certain bacteria (eg, Pseudomonas aeruginosa, Acinetobacter, or Staphylococci) may require higher doses of ciprofloxacin and combination with other appropriate antibacterial agents.

In the treatment of certain infections (for example, inflammatory diseases of the pelvic organs, intra-abdominal infections, infections in patients with neutropenia and infections of the bones and joints), the simultaneous appointment of other antibacterial drugs is possible.

Teens 15 − 17 years:

Bronchopulmonary infections in cystic fibrosis caused by Pseudomonas aeruginosa: 20 mg / kg 2 times a day, but not more than 750 mg per dose. Duration of application (taking into account parenteral administration) - 10 - 14 days.

Use in elderly patients:

In elderly patients, the dosage of the drug depends on the severity of the infection and creatinine clearance.

Patients with impaired renal function:

Patients with impaired liver function:

Dose adjustment is not required.

Mode of application

Capsules should be swallowed without chewing with a small amount of boiled water. The drug can be taken regardless of food intake. When taken on an empty stomach, the drug is more rapidly absorbed. Ciprofloxacin should not be taken with dairy products (milk, yogurt) or mineral-fortified fruit juices (eg, calcium-fortified orange juice). In severe cases, or if the patient is unable to take capsules (eg, patients on enteral nutrition), it is recommended to start therapy with intravenous forms of ciprofloxacin, followed by a transition to oral forms.

If a capsule is missed, it should be taken as soon as possible and the next one at the usual time. However, if the next dose is due, the missed dose should not be taken. You should not compensate for the missed dose by increasing the dose at the next dose.

Side effect

Often (≥ 1/100,

From the nervous system: infrequently - headache, dizziness, sleep disturbance, taste disturbances, psychomotor hyperactivity, agitation; rarely - paresthesia, dysesthesia, hypoesthesia, tremor, seizures, confusion and disorientation, anxiety reactions, obsessive thoughts, depression, hallucinations; very rarely - migraine, impaired coordination of movements, impaired sense of smell, intracranial hypertension, psychotic reactions, the frequency is unknown - peripheral neuropathy.

From the side of the organ of vision: rarely - visual disturbances; very rarely - a violation of color perception.

From the organ of hearing: rarely - ringing in the ears, hearing loss; very rarely - hearing loss.

Infections and infestations: infrequently - mycotic superinfection; rarely - colitis associated with taking antibacterial drugs (very rarely a fatal outcome is possible).

From the immune system: rarely - allergic reactions, allergic edema / angioedema; very rarely - anaphylactic reactions, anaphylactic shock (life-threatening), symptoms similar to serum sickness.

From the gastrointestinal tract: often - nausea, diarrhea; infrequently - anorexia, vomiting, gastrointestinal and abdominal pain, dyspepsia, flatulence; rarely - pancreatitis.

From the side of metabolism and nutrition: rarely - hyperglycemia, hypoglycemia.

From the hepatobiliary system: infrequently - an increase in transaminases, an increase in bilirubin; rarely - impaired liver function, cholestatic jaundice, hepatitis; very rarely - liver necrosis.

From the side of the skin: infrequently - rash, itching, urticaria; rarely - photosensitivity; very rarely - petechiae, erythema nodosum, erythema multiforme, Stevens-Johnson syndrome (potentially life-threatening), toxic epidermal necrolysis (Lyell's syndrome, potentially life-threatening).

From the musculoskeletal system: infrequently - pain in the bones, muscles (for example, pain in the limbs, pain in the back, in the chest), arthralgia; rarely - myalgia, arthritis, increased muscle tone, convulsions, very rarely - muscle weakness, tendinitis, tendon rupture (mainly Achilles tendon), exacerbation of symptoms of myasthenia gravis.

Children: the frequency of the arthropathies mentioned above is based on data collected in studies with adults. In children, arthropathies are usually recorded frequently.

From the side of the cardiovascular system: rarely - tachycardia, vasodilation, hypotension, syncope; very rarely - vasculitis; frequency unknown - ventricular arrhythmia and torsades de pointes ( torsades de pointes) (reported predominantly in patients with a known risk of QT prolongation), prolongation of the QT interval on the ECG.

From the respiratory system: rarely - dyspnea (including asthmatic condition). From the hematopoietic system: infrequently - eosinophilia; rarely - leukopenia, anemia, neutropenia, leukocytosis, thrombocytopenia, thrombocythemia; very rarely - hemolytic anemia, agranulocytosis, pancytopenia (life-threatening), bone marrow depression (life-threatening).

From the urinary system: infrequently - impaired renal function; rarely - hematuria, crystalluria, tubulointerstitial nephritis.

From the side of laboratory indicators: infrequently - increased activity of alkaline phosphatase; rarely - an increase in prothrombin, amylase.

Others: infrequently - asthenia, fever; rarely - swelling, increased sweating.

In the event of the above adverse reactions, as well as adverse reactions not listed in this leaflet, you should consult a doctor.

Contraindications

Hypersensitivity to ciprofloxacin, other quinolones or to any of the excipients of the drug, deficiency of glucose-6-phosphate dehydrogenase, epilepsy, children under 18 years of age (except for children 15–17 years of age with bronchopulmonary infections in cystic fibrosis caused by Pseudomonas aeruginosa), pregnancy, breastfeeding. The simultaneous appointment of ciprofloxacin and tizanidine is contraindicated (see "Interaction with other drugs").

Overdose

There is evidence of an overdose at a dose of 12 g, which led to mild symptoms of intoxication, as well as an acute overdose at a dose of 16 g, which caused acute renal failure.

Symptoms: dizziness, tremor, headache, fatigue, convulsions, hallucinations, confusion, abdominal discomfort, kidney and liver failure, crystalluria and hematuria. There are reports of reversible renal toxicity. Treatment: in addition to the usual emergency measures (gastric lavage, administration of activated charcoal), the introduction of a large amount of fluid, the creation of an acidic urine reaction, it is necessary to monitor kidney function, perform hemodialysis and peritoneal dialysis (less than 10% of the dose taken can be withdrawn). All activities are carried out against the background of maintaining vital functions. There is no specific antidote. ECG monitoring should be carried out due to possible prolongation of the QT interval.

Precautionary measures

invalidizing and potentially irreversible serious adverse reactions that can occur simultaneously. The use of fluoroquinolones, including ciprofloxacin, has been associated with disabling and potentially irreversible serious adverse reactions from various body systems that can occur in the same patient. These reactions include tendonitis, tendon rupture, joint pain, muscle pain, peripheral nerve damage, and central nervous system disorders. These reactions can occur within hours to weeks after starting ciprofloxacin. They have been observed in patients of any age or without preexisting risk factors.

At the first signs or symptoms of any serious adverse reactions (eg, swelling, pain in the tendons, joint and muscle pain, burning, tingling sensation, weakness or pain in the limbs, confusion, convulsions, severe headache, or hallucinations), immediately stop treatment and consult a doctor.

It is necessary to control the concentration in the blood of urea, creatinine, hepatic transaminases. In order to avoid the development of crystalluria, it is unacceptable to exceed the recommended daily dose, it is also necessary to have sufficient fluid intake and maintain an acidic urine reaction.

Monotherapy with ciprofloxacin may be ineffective in severe infections and infections caused by gram-positive or anaerobic pathogens. In these cases, additional administration of other antibacterial agents may be required.

Epididymo-orchitis and pelvic inflammatory disease can be caused by Neisseria gonorrhoeae resistant to fluoroquinolones. If stability cannot be ruled out Neisseria gonorrhoeae to ciprofloxacin, it is necessary to prescribe ciprofloxacin together with other antibacterial agents. In the absence of clinical improvement within 3 days of treatment, it is necessary to reconsider therapy. Data on the effectiveness of ciprofloxacin in the treatment of postoperative intra-abdominal infections are limited.

Traveler's diarrhea: when prescribing ciprofloxacin, information on the resistance of pathogens in this region should be taken into account.

Bone and joint infections: ciprofloxacin should be used in combination with other antimicrobials, depending on the results of microbiological testing.

Complicated urinary tract infections: Ciprofloxacin may be used to treat urinary tract infections when alternative treatments cannot be used. When prescribing the drug, the results of a microbiological study should be taken into account.

Musculoskeletal system: Ciprofloxacin should generally not be given to patients with tendon disease/disorders and a history of quinolone use. The appointment of ciprofloxacin is possible only in very rare cases after a microbiological study of the pathogen and an assessment of the risk / benefit ratio for the treatment of certain severe infections with ineffectiveness or resistance to standard therapy with confirmed sensitivity of the pathogen to ciprofloxacin. Ciprofloxacin can cause tendinitis and tendon rupture (especially the Achilles tendon), sometimes bilateral, more often in the first 48 hours of treatment. The risk of tendinopathies is increased in elderly patients and patients taking corticosteroids. At the first signs of tendovaginitis (eg, painful swelling, inflammation), ciprofloxacin should be discontinued and rest prescribed. It is necessary to exclude physical activity on the injured limb. Ciprofloxacin should be used with caution in patients with myasthenia gravis due to possible increased muscle weakness.

Photosensitivity: ciprofloxacin may cause photosensitivity. Patients taking ciprofloxacin should avoid exposure to direct sunlight or UV radiation.

Central nervous system: quinolones can provoke the development of seizures or a decrease in the seizure threshold. Ciprofloxacin should be used with caution in patients with CNS disorders and a predisposition to seizures. With the development of seizures, the introduction of ciprofloxacin should be discontinued. The development of psychiatric reactions is possible even after the first administration of ciprofloxacin. In rare cases, depression or psychosis can progress to suicidal behavior. In these cases, the introduction of ciprofloxacin should be discontinued. Cases of polyneuropathy (manifested by symptoms such as pain, burning, sensory disturbances, or muscle weakness ", alone or in combination) have been reported in patients treated with ciprofloxacin. Ciprofloxacin should be discontinued in patients experiencing symptoms of neuropathy, including pain, burning, tingling, numbness and / or weakness in order to prevent the development of irreversible changes.

The cardiovascular system: Since the use of ciprofloxacin is associated with cases of prolongation of the QT interval, caution should be exercised in the treatment of patients with risk factors for the development of ventricular arrhythmias and torsades de pointes ( torsade depointes):

- congenital syndrome of prolongation of the QT interval;

- concomitant use of drugs known to prolong the QT interval (eg class IA and III antiarrhythmic drugs, tricyclic antidepressants, macrolides, antipsychotics);

- electrolyte disturbances, especially uncorrected hypokalemia, hypomagnesemia;

- women and elderly patients are more sensitive to the effects of drugs that prolong the QT interval, such as ciprofloxacin, so special care is required;

- heart disease (for example, heart failure, myocardial infarction, bradycardia) (see sections "Method of application and doses", "Interaction with other drugs", "Side effects", "Overdose").

Gastrointestinal tract: if severe and persistent diarrhea occurs during or after treatment (including within a few weeks after treatment), it is necessary to exclude pseudomembranous colitis, which requires immediate discontinuation of the drug and the appointment of appropriate treatment. The appointment of drugs that reduce peristalsis is contraindicated in this situation.

Kidneys and urinary system: possible development of crystalluria while taking ciprofloxacin. Patients taking ciprofloxacin should drink enough fluids and avoid shifting the urine reaction to the alkaline side.

Hepatobiliary system: cases of liver necrosis with the development of liver failure have been reported while taking ciprofloxacin. In the event of signs and symptoms of liver disease (eg, anorexia, jaundice, dark urine, pruritus or abdominal tenderness), treatment should be discontinued. hypoglycemia

As with the use of other quinolones, cases of hypoglycemia have been reported with the use of ciprofloxacin, most often in patients with diabetes mellitus, especially in the elderly. Close monitoring of blood glucose levels is recommended in all diabetic patients.

Glucose-b-phosphate dehydrogenase: when using ciprofloxacin in patients with glucose-6-phosphate dehydrogenase deficiency, hemolysis may develop. Resistance: possible development of superinfection during or after the use of ciprofloxacin. There is a potential risk of selection of ciprofloxacin-resistant pathogens during long-term treatment and treatment of nosocomial infections and / or infections caused by Staphylococcus and Pseudomonas.

Impact on tests: in vitro ciprofloxacin inhibits growth Mycobacterium tuberculosis, which can lead to false negative results in the diagnosis of this pathogen in patients taking ciprofloxacin.

Cytochrome P450: ciprofloxacin inhibits the cytochrome isoenzyme CYP1A2 and therefore can lead to an increase in serum concentrations of concomitantly used substances that are metabolized by this enzyme (for example, theophylline, clozapine, ropinirole, tizanidine). The combined use of ciprofloxacin and tizanidine is contraindicated. In patients receiving ciprofloxacin concomitantly with CYP1A2-metabolized agents, clinical signs of overdose should be monitored, and serum concentrations of these agents (eg, theophylline) may need to be monitored.

Methotrexate: concomitant use of ciprofloxacin with methotrexate is not recommended.

Children and teenagers

Ciprofloxacin is not the drug of first choice in the pediatric population due to an increased risk of side effects, including those associated with the joints and/or surrounding tissues.

Ciprofloxacin in children and adolescents should be used in accordance with official guidelines.

Treatment with ciprofloxacin should only be carried out by physicians who are experienced in the treatment of cystic fibrosis and/or other severe infections in children and adolescents. It has been experimentally established that ciprofloxacin causes arthropathy of the supporting joints of immature animals.

Therefore, due to possible side effects associated with the joints and/or surrounding tissues, treatment should only be initiated after an assessment of the benefit/risk ratio.

Use during pregnancy and lactation

Pregnancy

Available data on the use of ciprofloxacin in pregnant women indicate the absence of congenital feto/neonatal toxicity. Animal studies have shown no direct or indirect harmful effects in terms of reproductive toxicity. Effects on immature cartilage have been observed in quinolone-exposed animals, so it is possible that the drug may cause articular cartilage damage in an immature child/fetus.

As a precautionary measure, it is preferable to avoid the use of ciprofloxacin during pregnancy.

Lactation

Ciprofloxacin is excreted from the body with breast milk.

Due to the potential risk of joint damage, ciprofloxacin should not be used during breastfeeding.

Influence on the ability to drive vehicles and other potentially dangerous mechanisms

Due to the risk of side effects of ciprofloxacin on the nervous system, there may be an effect on reaction time. Thus, the ability to drive vehicles or operate other mechanisms may be impaired. During treatment, you should refrain from driving vehicles and working with moving mechanisms.

Interaction with other drugs

Effect of other medicinal products on ciprofloxacin:

Chelating agents: concomitant administration of ciprofloxacin (oral) with agents containing polyvalent cations or mineral supplements (eg, containing calcium, magnesium, aluminium, iron), polymeric phosphate binders (eg, Sevelamer), sucralfate, or antacids, as well as highly buffered drugs ( for example, didanosine tablets) containing magnesium, aluminum or calcium reduce the absorption of ciprofloxacin. It is recommended to prescribe ciprofloxacin 1 to 2 hours before or at least 4 hours after taking these drugs. The restriction does not apply to H2 receptor blockers.

Food and dairy products: calcium contained in food does not significantly affect absorption. However, the concomitant use of ciprofloxacin with dairy products or mineral-fortified drinks (eg, milk, yoghurts, calcium-fortified orange juice) should be avoided due to a possible decrease in absorption.

Probenecid: Probenecid affects the renal secretion of ciprofloxacin. Co-administration of probenecid and ciprofloxacin increases the serum concentration of ciprofloxacin.

Metoclopramide: metoclopramide accelerates the absorption of ciprofloxacin so that the maximum plasma concentration is reached in less time. The bioavailability of ciprofloxacin does not change.

Omeprazole: the simultaneous use of ciprofloxacin and drugs containing omeprazole leads to a slight decrease in the Cmax and AUC of ciprofloxacin.

Drugs with an established risk factor for QT interval prolongation: ciprofloxacin, like other fluoroquinolones, should be used with caution in patients receiving drugs with a known risk factor for prolongation of the QT interval (for example, class IA and III antiarrhythmic drugs, tricyclic antidepressants, macrolides, antipsychotics (see section "Precautions") ).

Effect of ciprofloxacin on other medicinal products:

Tizanidine: the simultaneous administration of tizanidine with ciprofloxacin is contraindicated. In a clinical study with healthy people, an increase in serum concentrations of tizanidine (Cmax: 7-fold increase, range: 4 to 21; AUC: 10-fold increase, range: 6 to 24) was observed with ciprofloxacin. An increase in serum tizanidine concentration is associated with potentiation of hypotensive and sedative effects.

Methotrexate: it is possible to block the tubular secretion of methotrexate while prescribing ciprofloxacin, which can lead to an increase in plasma levels of methotrexate and the development of toxic reactions of methotrexate. Co-administration with ciprofloxacin is not recommended.

Theophylline: the simultaneous use of ciprofloxacin and theophylline can lead to an undesirable increase in the concentration of theophylline in serum and the development of side effects of theophylline. With the joint appointment of theophylline and ciprofloxacin, it is necessary to control the concentration of theophylline in the blood serum and reduce the dose of theophylline if necessary.

Other xanthine derivatives: administration with ciprofloxacin leads to an increase in the concentration of caffeine and pentoxifylline (oxpentifylline) in the blood serum.

Phenytoin: the simultaneous use of ciprofloxacin and phenytoin can lead to an increase or decrease in the concentration of phenytoin in the blood serum, which requires monitoring the level of the drug.

Oral anticoagulants: the simultaneous use of ciprofloxacin and warfarin may lead to an increase in the anticoagulant effect. There are many reports of increased activity of oral anticoagulants in patients receiving antibacterial drugs, including fluoroquinolones. The change in activity may depend on the infection, age and severity of the patient's condition, so the effect of fluoroquinolones on the increase in INR (international normalized ratio) is difficult to predict. Careful monitoring of INR during and shortly after co-administration of ciprofloxacin and an oral anticoagulant is recommended.

Ropinirole: ciprofloxacin, being a moderate inhibitor of cytochrome P450 1A2, leads to an increase in Cmax and AUC of ropinirole by 60% and 84%, respectively, with simultaneous use. It is recommended to monitor side effects caused by ropinirole and adjust the dose if necessary during and shortly after co-administration with ciprofloxacin.

Clozapine: ciprofloxacin increases the concentration of clozapine in the blood serum. Monitoring and appropriate dose adjustment of clozapine during and shortly after co-administration with ciprofloxacin is recommended.

Cyclosporine: with the simultaneous use of ciprofloxacin and cyclosporine, a short-term increase in serum creatinine concentration was observed. Therefore, these patients should regularly (2 times a week) monitor the concentration of creatinine in the blood serum.

Duloxetine: In clinical studies, it has been shown that with the concomitant use of duloxetine with strong inhibitors of the CYP450 1A2 isoenzyme, such as fluvoxamine, there may be an increase in the AUC and Cmax of duloxetine. Despite the lack of clinical data on possible interactions, similar effects can be expected in the case of concomitant use with ciprofloxacin.

Sildenafil: Co-administration with ciprofloxacin resulted in an approximately two-fold increase in Cmax and AUC of sildenafil in healthy volunteers after an oral dose of 50 mg given at the same time as 500 mg of ciprofloxacin. Therefore, caution should be exercised when using ciprofloxacin and sildenafil together and carefully evaluate all risks and benefits.

Lidocaine: in healthy volunteers, it was found that the concomitant use of drugs containing lidocaine with ciprofloxacin, a moderate inhibitor of the CYP450 1A2 isoenzyme, reduced the clearance of intravenous lidocaine by 22%. Although treatment with lidocaine is well tolerated, possible interactions with concomitant ciprofloxacin are associated with an increased risk of side effects.

Holiday conditions

On prescription.

Manufacturer:

RUE "Belmedpreparaty"

Republic of Belarus, 220007, Minsk,

st. Fabriciusa, 30, t./fa.: (+375 17) 22037 16,

e-mail: [email protected]

A breeder of fluffy purrs should carefully monitor the health and behavior of their pets. But if it so happened that the cat fell ill with a viral-bacterial infection, in order to avoid the development of serious complications, you should immediately contact the attending veterinarian. After a scheduled examination, a comprehensive diagnosis, the four-fingered patient will be prescribed effective therapeutic therapy. For example, your cat may be prescribed Ciprovet tablets, an effective oral veterinary drug that is prescribed to animals to treat bacterial and viral infections. The drug has a wide spectrum of action.

Composition and forms of release

Ciprovet is a complex antibacterial veterinary drug belonging to the group of fluoroquinolones. Note that fluoroquinolones have no natural analogues. Produced in the form of tablets, covered with a yellow shell. The drug, intended for oral administration, is packaged in ten tablets, which are packed in metal blisters.

In traditional veterinary practice, Ciprovet is used in the treatment of acute, chronic bacterial infections of the gastrointestinal tract, organs of the respiratory, genitourinary tract, biliary tract in cats of various breeds and age groups.

Important! Ciprovet is also available in the form of ophthalmic drops in glass vials for the treatment of conjunctivitis, keratitis, eye diseases of various etiologies and pathogenesis.

The main active component of the pharmacological agent is ciprofloxacin hydrochloride. Each tablet contains 15 mg of the substance. The composition of the pills also includes excipients: lactulose, starch, calcium stearate, which enhance the action of the main components.

Pharmacological properties

Ciprofloxacin, which is part of the veterinary drug, belongs to the fluoroquinolones. It has a wide spectrum of antibacterial action. Effective against various types of gram-positive, gram-negative bacteria: Escherichia coli, strepto-staphylococci, salmonella, listeria, mycobacteria, chlamydia, shigella, brucella, toxoplasma, protozoan pathogenic fungi.

Ciprofloxacin blocks the bacterial enzyme DNA gyrase, which affects the replication of the DNA helix in the nucleus of bacterial cell structures of prokaryotes. A similar mechanism of action of chemicals interferes with the process of protein synthesis and leads to the rapid death of disease-causing agents (pathogenic microorganisms).

After oral administration, the active components of the drug are rapidly absorbed in the gastrointestinal tract, mainly in the small intestine, evenly distributed in the tissues and internal organs of warm-blooded animals. Substances of the drug penetrate into the blood, lymph, which contributes to a uniform distribution of the drug in the body of infected animals, as well as an immediate effect on the lesion.

The drug has a pronounced antibacterial, antiseptic, anti-inflammatory effect, relieves the clinical symptoms of an infectious disease, and normalizes the general physiological state of a sick cat.

Important! The maximum concentration of ciprofloxacin in the blood plasma is noted two hours after taking the medication. At the same time, the therapeutic concentration is maintained throughout the day after the oral use of the antibacterial drug and after five to six hours from the drops. At the same time, a full-fledged therapeutic effect is observed on the third or fifth day with the systematic use of Ciprovet in the recommended dosage.

The active substances of the drug are excreted from the body with bile, urine, less often with feces. In lactating animals - with milk, colostrum.

Ciprovet belongs to the group of moderately toxic veterinary drugs. If the frequency of administration and dosage is not observed, it can provoke side effects. It has a prolonged therapeutic effect, is quickly excreted from the body of pets, has an affordable cost.

Indications for use

Ciprovet is prescribed for fluffy purrs in the treatment of various bacterial infections that occur in acute, chronic form, as well as in case of exacerbation of systemic diseases.

Indications for use:

• bacterial infections of the gastrointestinal tract;
• diseases of the biliary tract caused by pathogenic flora;
• infectious respiratory diseases;
• pathologies, infectious diseases of the urinary tract;
• for the treatment of dermatological diseases, elimination of inflammatory
• processes in various structures of the dermis, cartilage, joints;
• eliminate the symptoms of secondary, associated infections.

Ciprovet for cats can also be prescribed after the end of medical therapy as a preventive measure to prevent relapses in case of re-infection. In addition, an antibacterial drug is used to treat secondary infections, the causative agents of which are sensitive to this drug, which developed against the background of a general disease.

Veterinarians often prescribe an antibacterial drug in the treatment of chlamydia, mycoplasmosis, toxoplasmosis, brucellosis, salmonellosis, listeriosis, intestinal, strepto-staphylococcal, mixed infections in cats.

Ciprovet in drops is used in cats for inflammatory ophthalmic diseases: conjunctivitis, uveitis, keratitis, blepharospasm, and also as a prophylactic for mechanical damage, bruises, and eye injuries.

Dosage and instructions for use

Before using the drug, carefully read the annotation for use, strictly adhering to the prescribed dosage. Follow all the recommendations of the attending veterinarian so as not to harm your furry pet. The frequency of taking the drug, the duration of therapeutic therapy is determined by the veterinarian on an individual basis, taking into account the form, degree of infection, localization of the pathogenic flora, age, and the general physiological state of the animals.

Dosage of Ciprovet for cats: one tablet is calculated for three kilograms of the animal's body weight. The course of treatment is three to six days. The medicine is given to the cat once a day. The tablet is forcibly placed on the root of the tongue or crushed into powder, after which it is given with a favorite delicacy - raw minced meat, a piece of cheese, cottage cheese. Be sure to follow up or the cat swallowed the pill. Do not forget that cats not only have an excellent sense of smell, but also very resourceful, cunning animals.

Important! Treatment of cats with Ciprovet is carried out until the clinical symptoms of an infectious disease are completely relieved. If there is no improvement on the third day, consult a veterinarian.

When using drops, one drop of Tsiprovet is instilled into each eye of a cat, having previously treated the eyes of a fluffy pet with an antiseptic solution using a sterile cotton-gauze disk. The procedure is recommended to be repeated three to four times a day for 7-14 days. That is, until the pet is completely cured.

Contraindications and side effects

Ciprovet is a low-toxic drug for animals, so side effects are noted in rare cases, unless, of course, the dosage is adhered to.

In cats in case of individual intolerance. hypersensitivity to the active components of the drug in the first day after administration is noted:

• increased salivation:
• decreased physical activity:
• increased thirst:
• vomiting, nausea;
• the appearance of edema;
• convulsions, muscle spasms;
• allergic manifestations, small skin rash.

An antibacterial drug is not used to treat pregnant, lactating cats, small kittens up to seven months of age or until complete cessation of growth and physiological development. The medicine is contraindicated in elderly cats, severely malnourished, weakened individuals, animals with chronic renal and hepatic insufficiency. Ciprovet is also not prescribed for cats with endocrine pathologies, CNS disorders (convulsions, muscle spasms).

Ciprovet is not compatible with some groups of drugs, in particular with bacteriostatic antibiotics - chloramphenicol, macrolides, tetracycline drugs. If you use a veterinary drug in combination with non-steroidal anti-inflammatory drugs, drugs that contain calcium, magnesium, aluminum cations, its effectiveness will be reduced. Therefore, we categorically do not recommend self-medicating a pet without first consulting with the attending veterinarian.

With the manifestation of characteristic side symptoms in cats, the drug is stopped, desensitizing therapy is carried out.

The only reliable way to deal with a disease caused by bacteria is through the use of antibiotics. The veterinary drug "Tsiprovet", intended for cats and dogs, has established itself as a high-quality, effective drug of moderate cost.

The active substance in the composition of "Tsiprovet" is ciprofloxacin in the form of a salt of hydrochloric acid, a representative of the second generation of fluoroquinolones. It kills the widest range of pathogens due to the ability to destroy the cell walls of bacteria. In addition, ciprofloxacin is able to destroy cell organelles that form resistance to antibiotics. This mechanism of action makes it impossible for bacterial strains to appear resistant to Ciprovet.

I also like that the generic versions are powdered in capsules so you can easily sprinkle it on wet food if needed for pets that don't find it easy to administer pills. The general version is available for groups of different animal sizes.

People who say it doesn't work are crazy! So this should be used as part of the regimen. Others claim that "only worked one day!" Spirit. Another clueless tweet wrote: This is not my house! So, are you dimming enough to think that fleas can't infest a house with a hard floor? Do you also sleep in a hardwood bed?

The manufacturer of the drug "Tsiprovet" is the Russian company "Agrovetzashchita".

Microorganisms against which "Tsiprovet" is effective:

• The causative agent of anthrax;
• The causative agent of meningitis;
• Staphylococcus aureus, including those resistant to antibiotics
• strains;
• Saprophytic staphylococcus;
• Streptococci;
• Pasteurella;
• Salmonella.

Resistant to the effect of the drug "Tsiprovet":

Did you realize that fleas can fit between hardwood planks and between slabs and furniture? for people who are a little dim or inexperienced. These works are designed for a maximum of 24 hours. Efficiency ends after a day, when the medicine stops working. This gives you time to clean up.

Get and saw the pill. Just read the packaging instructions. These pills will not kill eggs left on your pet, you will need to bathe your pet with a homemade shampoo that claims to kill flea eggs. Wash your pet, take your time. If you are in a hurry to bathe, the shampoo will not have time to work. Most of your fleas will be dead. It's sad, yes, but you have to kill live fleas, but you can. Wash out all fleas, dead or alive. Do not spray around pets, keep pets away from treated areas for at least one hour.

• Actinomycetes;
• Mycoplasmas;
• Clostridia.

Ciprovet is produced for cats in two forms: in the form of a solution for instillation of the eyes and in the form of tablets for oral administration. Eye drops have a local effect on the harmful microflora. Tablets affect the entire body, so different forms of the drug are used to treat different diseases. Each has its contraindications.

Follow the flea spray directions, don't forget to spray your pets' favorite resting places. You want to wash pet bed linen, clothes, linens, any fabric lying around like blankets where fleas can hide, including the towels you dried your pet after their bath. If you have carpets or cat trees or other unwashed items where your pet spends time, clean those areas thoroughly. Be sure to move things and be very careful.

One missed flea can make more moments in the blink of an eye. Why are these pills used if they only work for one day? When you bathe a pet, the fleas run towards their face. It is dangerous to apply flea shampoo on your pets face, such as around the eyes, nose and mouth, and exactly where whites run. Used in tandem with flea bathing and a thorough house cleaning, these tablets ensure you don't miss any of the fleas crawling on your pet. This also ensures that those who jump back on your pet while cleaning also die.

Solution for instillation of eyes

Solution for instillation of eyes "Tsiprovet" looks like a clear liquid without color and odor. The manufacturer packs the solution in plastic or glass bottles with a volume of 1, 5 and 10 ml. Original drops "Tsiprovet" are packed one by one in cardboard boxes.

Composition and pharmacological properties

These tablets are cheaper than monthly pet insecticide tablets and more effective than the harsh topical insecticides you'll get on your hands petting your cat or dog, and it will also be licked by feline cats, who will get sick from ingesting the topical insecticide.

Dosage and instructions for use

If you are lazy and don't bathe your pet and clean your house, you will be wasting your money. That's where these one-star ratings come from. There is no really lazy way out of a flea infestation, but you can save time and effort by using these pills.

Sediment, turbidity and impurities in the solution are a sign that the medicine is not suitable for use.

Indications

Drops "Tsiprovet" are used to suppress harmful microflora in the eyes.

Assign "Tsiprovet" for cats if they are diagnosed with:

acute, sluggish or purulent inflammation of the cornea of ​​the eye, the mucous membrane of the eyelids;
acute or chronic inflammation of the conjunctiva of the eye;
mechanical damage to the eyes (trauma, punctures, etc.);
ulcerative lesions of the surface of the cornea or the inner part of the eyelids;
inflammatory processes in the iris, which are caused by bacteria.

For truly crazy flea infestations that you walk into and have fleas covering your feet, add a new step. Buy flea bombs, one per room, and follow the instructions. Leave the bombs to do their work while all living beings leave your house for an hour or two.

Any pet that goes outside is very likely to bring them. And besides, some yards and places breed taller specimens of fleas. They sell killer fleas that you can spray across your yard. This is a big investment for dog owners who have no choice but to take their pet outside. Also, fleas can still exist in your home throughout the winter if you don't see them and show up when the weather warms up. Winter is the best time to kill them because they are less active in cold areas.

Use drops "Tsiprovet" is prescribed by a veterinarian.

Apply drops "Tsiprovet" for cats that are preparing or have undergone eye surgery, as a prevention of infectious inflammatory processes.

Drops cost about 135 rubles.

Contraindications

Solution for instillation of eyes "Tsiprovet" acts exclusively locally. It is not absorbed into the blood or lymph and its action is limited to the structures of the eye. Therefore, there are few restrictions in its use compared to tablets.

Solution for instillation of eyes

Give them a dick and keep cleaning. These pills are not drugs and are not meant to be, but they get the job done and will greatly contribute to your efforts. From light to dark brown tablets with a smooth or slightly rough surface and a round shape. Marble, speck, or both may be visible.

Fleas and ticks must stick to the host and start with a meal in order to be exposed to the active substance. The effect starts with fleas within 8 hours with ticks within 12 hours of sticking. A veterinary medicinal product may be used as part of a treatment strategy for flea allergy dermatitis.

Do not use drops "Ciprovet" for cats with increased susceptibility to fluoroquinolone antibiotics (ciproflokasacin, ofloxacin, moxifloxacin).

If drops of "Tsiprovet" for cats were prescribed for the first time and they had not previously been given antibiotics similar in composition, it is necessary to check if there is a reaction to the drug. To do this, the cat is dripped one drop of the solution and observed for 20 minutes. If after this time the redness does not increase and the cat is not worried, the application medicines are safe.

Do not use in case of known hypersensitivity to the active substance or any of the excipients. In clinical studies, side effects commonly observed were mild and transient gastrointestinal effects such as diarrhea, vomiting, loss of appetite, and increased salivation.

In very rare cases, spontaneous reports of lethargy have been reported. The frequency of side effects is determined as follows:. - Often. - Normal - Random - Rare - Very rare. If you notice any side effects, especially those not listed in the leaflet, tell your veterinarian or pharmacist.

Do not use Tsiprovet drops for kittens that are less than a week old.

After using the full dose of the drug, the cat may feel a burning sensation - rubbing his eyes with his paw or rubbing his head against other objects. Unpleasant sensations and lacrimation usually disappear on their own after 5-7 minutes.

If the cat continues to worry for a longer time, rinse the treated eye with warm, sterile saline and alert the veterinarian.

Dosage for each type, type and duration of use

For dogs over 56 kg body weight, use the two tablet combination that best covers body weight.

Instructions for correct use

When used, the dog must fully accept the tablet. Treatment Schedule: For optimal control of flea infestation, the veterinary medicinal product should be administered at 12 week intervals. The re-treatment time depends on the type of tick for optimal control of the ticks. Section "Application areas". Keep out of the reach of children. The expiration date refers to the last day of the month.

Apply "Tsiprovet" for cats with pathologies of the blood supply to the brain should be used with caution and under the supervision of a veterinarian.

Interaction with other drugs

The active substance "Tsiprovet" is not stable and easily destroyed, so it is important not to mix it with other medicines. Ciprofloxacin loses its effectiveness in an acidic environment, after contact with drugs that contain various metals.

Special precautions for use in animals. The veterinary medicinal product should not be used in puppies under 8 weeks of age and in dogs weighing less than 2 kg due to lack of data. The veterinary medicinal product should not be used at intervals of less than 8 weeks as tolerance has not been tested at shorter intervals.

Special precautions for the user. Keep the veterinary medicinal product in its original packaging until you can use it to prevent direct access to children. Do not eat, drink or smoke while handling the veterinary medicinal product. Wash hands thoroughly with soap and water after using veterinary drugs.

Scheme of use

Due to the instability of ciproflosacin, Ciprovet drops for cats are used no earlier than 5 minutes after using other medicines.

Usually "Tsiprovet" for cats is dripped into the sore eye 4-5 times a day, 1 drop, trying to get under the eyelid. After the treated eye is covered with a hand so that the medicine is distributed evenly.

Fertility, lactation and reproductive capacity. Veterinary medicinal product can be used for breeding animals, as well as for pregnant and lactating dogs. Interaction with other drugs and other forms of interaction.

Compatibility has been demonstrated in breeding animals, as well as in pregnant and lactating animals receiving overdoses up to 3 times the maximum recommended dose. Tolerance has been demonstrated in 8-9 week old puppies weighing 2.0-3.6 kg who were treated with an overdose of 5 times the maximum recommended dose at 3 time points at shorter intervals than recommended. The veterinary drug was well tolerated in collies with a defective multidrug-resistant 1 protein after a single oral dose of 3 times the maximum recommended dose.

Other drops can be applied 5-7 minutes after Tsiprovet.

In acute cases, you can apply the medicine more often, up to 8 times a day.

If there is a lot of mucus or pus in the sore eye, before dripping "Tsiprovet", the eye is washed with warm saline, rubbed to clean it as much as possible. After such preparation, 3 drops of medicine are dripped into the eye, blotted with a sterile napkin and 1 more drop is added.

Doses and order of application

Incompatibility: unknown. Take special precautions when disposing of unused medicinal product or waste, if required. Ask your veterinarian to dispose of any unnecessary medications. These measures are used to protect the environment.

For oral administration, "Tsiprovet" for cats is made in the form of rounded tablets, packaged 10 per pack. In addition to ciprofloxacin, Ciprovet contains the prebiotic lactose. It helps to develop beneficial bacteria that slow down the reproduction of pathogenic microbes and are responsible for the normal functioning of the digestive tract.

When fleas sit on a dog's body and itch, they ingest this product, which is transferred to their eggs, preventing the birth of larvae. This avoids their multiplication. It is made with lufenuron, a benzoylurea derivative, which is administered orally and is rapidly absorbed, acting from the first moment. This component is an inhibitor of the synthesis of chitin, which prevents the reproduction of fleas.

They have a research team that makes it possible to create drugs that promote animal welfare. These tablets do not kill the adult flea, so it is possible that during the first 1-2 months an additional product is needed to treat the dog if it has been previously infected. It should be administered for at least 6 months, mainly during the hot seasons, and it is recommended to start treatment 1-2 months before the fleas start to engage. In addition, it is suitable for all races, pregnant women and puppies who eat solid foods.

Indications

Tablets "Tsiprovet" are prescribed to cats if they are diagnosed with:

1. Infectious diseases of the digestive tract caused by bacteria;
2. Inflammatory processes of the liver and gallbladder;
3. Inflammation of the lungs, bronchitis, severe tonsillitis;
4. Infectious inflammation of the genitourinary system;
5. Phlegmon, abscesses, boils and other purulent foci of inflammation;
6. Bacterial complications of viral infections.

You can use Ciprovet tablets for cats only as directed by a veterinarian!

Suitable for all races, pregnant women and babies who eat solid foods. It should be administered for at least 6 months, mainly during hot seasons, and it is recommended to start treatment 1-2 months before the fleas arrive. They do not kill the adult flea, so an additional product with an adult drug may be required for the first 1-2 months. .

Incorrect use of antibiotics can be life threatening!

Contraindications

The systemic effect on the body of Ciprovet tablets, in addition to the benefits, also brings with it a large number of side effects.

You can not use tablets "Tsiprovet" kittens and young cats

under 1 year old, pregnant women and during the feeding of young animals:

ciprofloxacin tends to destroy the articular surface during growth.

In addition, Ciprovet is not prescribed if the cat is allergic to fluoroquinolone antibiotics (ciproflokasacin, ofloxacin, moxifloxacin), there were diseases of the tendon or joints.

Side effects

An overdose of the drug can cause the following consequences:

1. Diarrhea;
2. Vomit;
3. Itching and skin rashes;
4. Interruptions in the work of the heart;
5. Lameness.

As first aid in such cases, you need to rinse the stomach and pour a weak solution of vinegar (1 teaspoon of essence in 1 glass of water).

Scheme of use

The dosage of the drug should be selected by a veterinarian!

Tablets "Tsiprovet" for cats are given at the rate of 1 tablet per 3 full kg of weight, 20 minutes after feeding.

You can not give "Tsiprovet" along with non-steroidal anti-inflammatory drugs (phenylbutazone), it can cause convulsions.

Preparations based on metals (calcium, magnesium, aluminum) destroy the active substance of the tablets. If the intake of such drugs is prescribed, then "Tsiprovet" is given no earlier than after 4 hours.

The cost of tablets is about 40 rubles for 10 pieces.

Analogues "Tsiprovet"

The tablet form of "Tsiprovet" can be replaced with medicines:

1. Ciprofloxacin;
2. Cypronate;
3. Cypronet;
4. Tsiprolet.

The solution for instillation of the eyes is replaced by medicines from a regular pharmacy:

1. Tsiprolet:
2. Ciprofloxacin-akos;
3. Ciprofarm;
4. Floximed.

Before using analogs, you need to calculate the dose you need for the cat.

Ciprovet tablets contain ciprofloxacin hydrochloride as an active ingredient: tablets for cats - 15 mg / tab. and tablets for dogs - 50 mg / tab., as well as auxiliary components (lactulose, calcium stearate and polyvinylpyrrolidone).
In appearance, the drug is a biconvex tablet with a diameter of 8 mm and a weight of 0.2 g; coated yellow (cat tablets) or white to gray (dog tablets).
Ciprofloxacin, which is part of the drug, belongs to the group of fluoroquinolones and has a wide spectrum of antibacterial action; active against gram-positive and gram-negative bacteria, including Echerichia coli, Salmonella spp., Shigella spp., Klebsiella spp., Enterobacter spp., Proteus spp., Yersinia spp, Haemophilus spp., Pseudomonas aeruginosa, Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium spp., Corynebacterium diphtheriase, Staphylococcus spp. and Streptococcus spp.
The mechanism of action of ciprofloxacin is based on blocking the enzyme DNA gyrase, which affects the replication of the DNA helix in the nucleus of a bacterial cell, which leads to disruption of protein synthesis and death of the microorganism.
After oral administration, ciprofloxacin is easily absorbed in the gastrointestinal tract (mainly in the duodenum and jejunum) and distributed in the organs and tissues of the body (excluding tissues rich in fats), penetrates into the pleura, peritoneum, lymph, ocular fluid and placenta.
The maximum concentration of ciprofloxacin in the blood serum is observed after 1.5-2 hours, the therapeutic concentration is maintained for 24 hours after oral administration of the drug.
Ciprofloxacin is excreted from the body mainly unchanged and partially in the form of metabolites with urine and bile, in lactating animals also with milk.
According to the degree of impact on the body, Ciprovet tablets are classified as moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76), in recommended doses they do not have a local irritant and resorptive-toxic effect, do not have embryotoxic and teratogenic properties.

INDICATIONS FOR USE.
Ciprovet tablets are prescribed for dogs and cats for therapeutic purposes in chronic and acute bacterial infections of the gastrointestinal tract, biliary tract, respiratory organs, genitourinary system, skin and soft tissues, bones and joints, as well as in secondary infections against the background of viral diseases, the causative agents of which susceptible to ciprofloxacin.

CONTRAINDICATIONS.
It is not allowed to use Ciprovet tablets in females during pregnancy and lactation, in animals with severe disorders in the development of cartilage tissue, with lesions of the nervous system accompanied by convulsions, as well as in puppies and kittens until the end of the growth period.
Ciprovet tablets should not be used simultaneously with bacteriostatic antibiotics (levomycetin, macrolides and tetracyclines), theophylline and non-steroidal anti-inflammatory drugs, as well as with drugs containing magnesium, aluminum and calcium cations, which, by binding to ciprofoxacin, prevent its adsorption.

SIDE EFFECTS.
As a rule, there are no side effects and complications in dogs and cats when using Ciprovet tablets in accordance with this instruction.
With increased individual sensitivity of the animal to fluoroquinolones and the appearance of side effects (refusal of food, vomiting, edema, impaired coordination of movements), the use of the drug is stopped and desensitizing therapy is carried out.

SPECIAL INSTRUCTIONS.
When working with Ciprovet tablets, you should follow the generally accepted personal hygiene and safety measures provided for medicines.

DOSES AND METHODS OF APPLICATION.
Ciprovet tablets are administered to animals individually orally once a day for 3-5 days in the following doses:
.cats - 1 tablet "for cats" for every 3 kg of animal weight;
.dogs 1 tablet "for dogs" for every 10 kg of animal weight.

STORAGE.
Store the medicinal product in the manufacturer's closed packaging, separately from food and feed, in a dry place, protected from direct sunlight, at a temperature of 0 0C to 25 0C.
Shelf life, subject to storage conditions, is 4 years from the date of manufacture.
After the expiration date, Ciprovet tablets should not be used.
Ciprovet tablets should be stored out of the reach of children.

RELEASE FORM.
Ciprovet tablets are produced in packs of 10 pieces in blisters, packed individually in cardboard boxes along with instructions for use.
Each blister is labeled with the manufacturer, name of the medicinal product, name and content of the active substance, batch number, expiration date, storage conditions, STO designation;
each box - indicating the manufacturer, its address and trademark, name, purpose, method of use of the medicinal product, number of tablets in the package, name and content of the active substance, date of manufacture, expiration date, storage conditions, STO designation, series number, number of state registration, information on confirmation of conformity and the inscription "For animals".