Mexiprim side effects. Mexiprim is an effective and inexpensive antioxidant

Registration number

ATX code

International non-proprietary name

Ethylmethylhydroxypyridine succinate

chemical name

3 - Hydroxy - 6 - methyl - 2 - ethylpyridine succinate

Dosage form

Solution for intravenous and intramuscular administration.

Compound

Composition per 1 ml:
Ethylmethylhydroxypyridine succinate 50mg
Water for injection - up to 1 ml.

Description

Colorless or slightly yellowish transparent liquid.

Pharmacotherapeutic group

Antioxidant agent.

Pharmacological properties

Pharmacodynamics
Mexiprim belongs to heteroaromatic antioxidants. Has a wide range of pharmacological activity: increases the body's resistance to stress, exhibits an anxiolytic effect, not accompanied by drowsiness and muscle relaxant effect; has nootropic properties, prevents and reduces learning and memory disorders that occur during aging and exposure to various pathogenic factors; has an anticonvulsant effect; exhibits antioxidant and antihypoxic properties; increases concentration and performance; weakens the toxic effect of alcohol.

The drug improves the metabolism of brain tissues and their blood supply, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets). It has a hypolipidemic effect, reduces the content of total cholesterol and low density lipoproteins.

The mechanism of action of Mexiprim is due to its antioxidant and membrane-protective action. It inhibits lipid peroxidation, increases the activity of superoxide oxidase, increases the lipid-protein ratio, reduces the viscosity of the membrane, and increases its fluidity. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission. Mexiprim increases the content of dopamine in the brain. It causes an increase in the compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, and stabilization of cell membranes.

Pharmacokinetics
The value of the maximum concentration of Mexiprim in blood plasma is in the range from 50 to 100 ng / ml.

The half-life of Mexiprim and the average retention time of the drug in the body are 4.7-5.0 hours and 4.9-5.2 hours, respectively. Mexiprim in the human body is extensively metabolized with the formation of its glucuronoconjugated product. On average, 0.3% of the unchanged drug and 50% in the form of a glucuronoconjugate from the administered dose are excreted in the urine over 12 hours. Mexiprim and its glucuronoconjugate are excreted most intensively during the first 4 hours after taking the drug. Urinary excretion rates of Mexiprim and its conjugated metabolite show significant individual variability.

Indications for use

Acute disorders of cerebral circulation (as part of complex therapy);
Encephalopathy;
Vegetative-vascular dystonia;
Anxious states in neurotic and neurosis-like states;
Mild cognitive disorders of various origins (psychoorganic and asthenic syndromes, consequences of traumatic brain injury, atherosclerosis, senile and atrophic processes, neuroinfections and intoxications);
Memory disorders and intellectual deficiency in the elderly;
Impact of extreme (stress) factors;
Withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;
Acute intoxication with antipsychotic drugs.

Contraindications

Acute hepatic and / or renal failure, increased individual sensitivity to the drug. Children's age, pregnancy, breastfeeding - due to insufficient knowledge of the drug's action in these categories of patients.

Dosage and administration

Mexiprim is prescribed intramuscularly or intravenously (stream or drip). Doses are selected individually. With the infusion method of administration, the drug should be diluted in physiological sodium chloride solution. Begin treatment with a dose of 50-100 mg 1-3 times a day, gradually increasing the dose until a therapeutic effect is obtained. Jet Mexiprim is injected slowly over 5-7 minutes, drip - at a rate of 40-60 drops per minute. The maximum daily dose does not exceed 800 mg.

In acute disorders of cerebral circulation, Mexiprim is used in complex therapy for the first 2-4 days intravenously, 200-300 mg 1 time per day, then intramuscularly 100 mg 3 times a day. The duration of treatment is 10-14 days.

With dyscirculatory encephalopathy in the decompensation phase, Mexiprim should be administered intravenously by stream or drip at a dose of 100 mg 2-3 times a day for 14 days. Then the drug is administered intramuscularly at 100 mg 2-3 times a day for the next 2 weeks. For course prevention of dyscirculatory encephalopathy, the drug is administered intramuscularly at a dose of 100 mg 2 times a day for 10-14 days.

For mild cognitive impairment in elderly patients and for anxiety disorders, the drug is used intramuscularly at a daily dose of 100-300 mg per day for 14-30 days.

With alcohol withdrawal syndrome, Mexiprim is administered at a dose of 100-200 mg intramuscularly 2-3 times a day or intravenously drip 1-2 times a day for 5-7 days.

In acute intoxication with antipsychotics, the drug is administered intravenously at a dose of 50-300 mg per day for 7-14 days.

Side effect

Rarely - nausea, dryness of the oral mucosa, drowsiness, allergic reactions.

Overdose

Symptoms: sleep disturbance (insomnia, in some cases - drowsiness).
Treatment: as a rule, it is not required - the symptoms disappear on their own within a day.
In severe cases of insomnia, it is recommended to take sleeping pills.

Interaction with other drugs

Mexiprim is compatible with psychotropic drugs; enhances the action of benzodiazepine anxiolytics, antiparkinsonian drugs and carbamazepine. Reduces the toxic effect of ethyl alcohol.

special instructions

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Release form

Solution for intravenous and intramuscular use 50 mg/ml.

In production at the Federal State Unitary Enterprise "Moscow Endocrine Plant", Russia: 2 ml or 5 ml in ampoules of neutral glass brand NS-3 or imported. 5 ampoules in a blister pack made of PVC film or PVC film and aluminum foil. 1, 2 or 3 blister packs with instructions for the medical use of the drug, a knife or an ampoule scarifier are placed in a cardboard pack.

For hospitals 6, 12, 20, 50 or 100 blisters with foil with 3, 6, 10, 25 or 50 instructions for the medical use of the drug, knives or ampoule scarifiers are placed in a cardboard box or in a corrugated cardboard box.

In the production at OOO NTFF Polisan, Russia: 2 or 5 ml in ampoules of neutral glass brand NS-3 or imported, or brown glass ampoules.

5 ampoules in a blister pack made of PVC film or PVC film and aluminum foil, or PVC film and cover film. 1, 2 or 3 blister packs with instructions for the medical use of the drug, a knife or an ampoule scarifier are placed in a cardboard pack.

For hospitals 6, 12, 20, 50 or 100 blister packs with foil or cover film, respectively, with 6, 12, 20, 50 or 100 instructions for the medical use of the drug, knives or ampoule scarifiers are placed in a cardboard box or in a corrugated cardboard box .

When packing ampoules with notches, rings or break points, scarifiers or ampoule knives are not inserted.

Storage conditions

In a place protected from light at a temperature not exceeding 20 ° C. Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date indicated on the package.

Holiday conditions

On prescription

Manufacturer

Federal State Unitary Enterprise "Moscow Endocrine Plant"
109052, Moscow, Novokhokhlovskaya street, 25

Or
OOO NTFF Polisan, Russia
192102, St. Petersburg, Salova st., 72, building 2 lit. A

Registration certificate holder

JSC "NIZHFARM", Russia,
603950, Nizhny Novgorod,
st. Salganskaya, 7

The active ingredient of the drug Mexiprim has antioxidant activity. It has an inhibitory effect on the development of free radical reactions, has membrane-protective activity. The drug prevents the development of hypoxia, prevents oxidative stress, has a nootropic effect.
Due to the positive effect on the processes in cerebral cells, it has an anticonvulsant, anxiolytic effect. The mechanism of action of Mexiprim is based on the inhibition of lipid peroxidation processes, an increase in the activity of the superoxide oxidase enzyme, a decrease in the viscosity of membrane structures, effects on the enzymatic activity of adenylate cyclase, calcium-independent phosphodiesterase, acetylcholinesterase, and effects on receptor complexes.
As a result of the influence of the drug, there is an improvement in the organization of membranes, the normalization of the transport of neurotransmitter substances, and an improvement in the processes of synaptic transmission. Against the background of the course of Mexiprim, there is an improvement in blood rheological parameters, normalization of microcirculation and metabolic processes in the brain, a decrease in the risk of thrombosis, stabilization of membranes of blood cells, a decrease in total cholesterol, LDL. When taking the drug, resistance to the effects of factors damaging the body, including the toxic effects of alcohol, antipsychotic drugs, increases.

Indications for use

tablet form Mexiprima is prescribed for: anxiety conditions against the background of neuroses, neurosis-like states; vegetovascular dystonia; cognitive disorders; intellectual insufficiency in gerontology; stressful influences; alcohol withdrawal with vegetovascular manifestations.
injection form Mexiprima is prescribed for: acute disorders of cerebral circulation; neurocirculatory dystonia; cognitive disorders on the background of atherosclerosis; anxiety states of moderate severity on the background of neurological disorders; alcohol withdrawal syndrome; dyscirculatory encephalopathy; intoxication with antipsychotic drugs; acute purulent-inflammatory pathologies of the abdominal cavity.

Mode of application

Mexiprim tablets taken orally. Depending on tolerance, the doctor prescribes a single and daily dose. A single dose of 0.25-0.4 g. The maximum allowable daily dose is 0.8 g. The frequency of administration is 2-3 times / day. The course of treatment for anxiety, cognitive, vegetovascular disorders - from 14 days to 6 weeks, for alcohol withdrawal - up to a week. Abrupt discontinuation is not indicated. Dosage reduction is carried out within 3 last days drug use.
injection solution Mexiprim used in / m or / in. Before intravenous administration with the help of infusion, a preliminary dilution of the injection solution of Mexiprim with 0.2 l of saline is carried out. solution. The introduction into the vein is carried out by jet or drip. The initial daily dosage is from 50 to 450 mg. Increasing the dosage is carried out gradually until the onset of a therapeutic effect. The speed of jet injection is 6 minutes, drip - 60 drops / minute. The maximum allowable daily dose is 0.8 g.
In case of acute violation of cerebral circulation, the scheme is as follows: 2-4 days of intravenous administration at 0.2-0.3 g / day, the next days of the course, the solution is administered intramuscularly at 1 ampoule (2 ml) / 3 times a day. The course is 10-14 days.
Dosage for parenteral administration in the first two weeks with dyscirculatory encephalopathy (DE) of the decompensated stage is 100 mg / 2-3 times. The next two weeks continue therapy at a dosage of 100 mg / day. Course prophylaxis of DE is carried out using the drug Mexiprim intramuscularly 100 mg (2 ml) / 2 times / day. Course - 2 weeks.
With mild cognitive impairment, increased anxiety, the use of the drug Mexiprim intramuscularly is indicated for a course of 2 weeks to 1 month. Dosage - 100-300 mg (1-3 ampoules of 2 ml per day).
With alcohol withdrawal, Mexiprim is used intramuscularly. Single dose - 100-200 mg, daily dose - 200-600 mg. With withdrawal symptoms after alcohol abuse, intravenous use of 1-2 amps / day is possible. The course is 5-7 days. Dosage for poisoning with antipsychotic drugs - 50-300 mg / day. The course is 1-2 weeks.
When used in the postoperative and preoperative periods of acute pancreatic necrosis, peritonitis, the dose is selected depending on the severity of the pathology, its form, and the type of clinical course. With interstitial pancreatitis, parenteral administration of the drug is indicated at a dosage of 100 mg / 3 times a day. With mild pancreatic necrosis, Mexiprim is used intravenously after dilution with physical. solution or intramuscularly without dilution. Dosage per day - 100-200 mg / 3 times. Dosage regimen for severe pancreatic necrosis: 400 mg / 2 times a day at the beginning of therapy, then 300 mg / 2 times a day.

A gradual dose reduction is mandatory. In extremely severe pancreatic necrosis, the dosage of 800 mg / day is maintained until the manifestations of pancreatogenic shock are completely stopped, then therapy continues at 600 mg / day.

Side effects

Taking the drug Mexiprim may be accompanied by: nausea; drowsiness; allergic reactions; coordination disorders; dry mouth; violations of the processes of falling asleep; anxiety; headaches; hypotension; hypertension; emotional reactivity.

Contraindications

A drug Mexiprim contraindicated in: indications in pediatrics; acute disorders of the liver; lactation; hypersensitivity to ethylmethylhydroxypyridine succinate, auxiliary components; acute disorders of the kidneys; pregnancy.

Pregnancy

During pregnancy Mexiprim not assigned. Contraindications are due to insufficient safety data.

Interaction with other drugs

Application of the drug Mexiprim with ethanol reduces the toxic effects of the latter. When used with benzodiazepines, potentiation of the action of anxiolytics is observed. When administered with levodopa, there is an increase in the effects of the antiparkinsonian drug. The appointment of carbamazepine with Mexiprim leads to an increase in the action of the anticonvulsant drug.

Overdose

Exceeding doses defined as therapeutic, accompanied by drowsiness. Special therapeutic measures in the absence of other symptoms are not required.

Storage conditions

Tablet storage temperature Mexiprim- up to 30 degrees Celsius, ampoules - up to 25 degrees Celsius. Shelf life of ampoules - 3 years, tablets - 5 years.

Release form

A drug Mexiprim produced in the following forms of release and packaging:
- 10 tab. / package;
- 2 ml × 5 amp. / package;
- 2 ml × 10 amp. / package;
- 20 tab. / package;
- 2 ml × 100 amp. / packaging for a hospital;
- 2 ml × 250 amp. / packaging for a hospital;
- 2 ml × 500 amp. / packaging for a hospital;
- 30 tab. / package;
- 5 ml × 5 amp. / package;
- 5 ml × 10 amp. / package;
- 5 ml × 100 amp. / packaging for a hospital;
- 5 ml × 250 amp. / packaging for a hospital;
- 5 ml × 500 amp. / packaging for a hospital;
- 40 tab. / package;
- 60 tab. / package.

Compound

1 tablet drug Mexiprim contains ethylmethylhydroxypyridine succinate 0.125 g. Auxiliary components: kaolin, MCC, sodium carboxymethyl starch, povidone, calcium stearate, talc, macrogol, hypromellose, titanium dioxide.
1 ampoule(2 ml) of the drug Mexiprim contains 0.1 g of ethylmethylhydroxypyridine succinate. Auxiliary component: sterile water.
1 ampoule(5 ml) of the drug Mexiprim contains 0.25 g of ethylmethylhydroxypyridine succinate. Auxiliary component: sterile water.

Additionally

Pediatric use is limited due to insufficient clinical data on safety and efficacy.
A negative effect of the drug on the concentration of attention, the speed of psychomotor reactions was noted. Because of this, you should refrain from hazardous activities, driving vehicles.

main parameters

Name:	MEXIPRIM
ATX code:	N07XX12 -

In this medical article, you can get acquainted with the drug Mexiprim. The instructions for use will explain in which cases you can take injections or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Mexiprim, from which you can find out if the medicine helped in the treatment of neuroses, neurasthenia and other mental disorders in adults and children, for which it is also prescribed. The instructions list analogues of Mexiprim, drug prices in pharmacies, as well as its use during pregnancy.

Mexiprim is an antioxidant drug. Instructions for use prescribes taking 125 mg tablets, injections in ampoules for injection in case of pathologies of the nervous system.

Release form and composition

Mexiprim is available in the form of coated tablets intended for oral administration. Tablets are packed in blisters of 10 pieces, 1-6 blisters in a cardboard box with detailed instructions attached.

Each tablet of the drug contains 125 mg of the active ingredient - Ethylmethylhydroxypyridine succinate, as well as a number of excipients.

They produce a solution for intramuscular and intravenous administration: a clear, slightly yellowish or colorless liquid (2 or 5 ml in ampoules). Composition of 1 ml of solution: active ingredient - ethylmethylhydroxypyridine succinate - 50 mg and water for injection - up to 1 ml.

pharmachologic effect

Mexiprim is an antioxidant agent. Under the influence of the active active ingredient, the body's resistance to stress and physical exertion increases. The drug improves the blood supply to areas of the brain suffering from a lack of oxygen and nutrients.

Under the influence of this drug, the patient's concentration increases, memory and perception of information improve. The drug weakens the toxic effect of alcoholic beverages and reduces the level of lipids and cholesterol in the blood.

Indications for use

What helps Mexiprim? Tablets and injections have general indications for use:

disorders of intelligence and memory in elderly patients;
the impact of stress;
withdrawal syndrome, accompanied by vegetative-vascular and neurosis-like disorders in alcoholism;
nervous disorders;
cognitive disorders in asthenic and psychoorganic syndrome caused by intoxication, circulatory disorders in the brain, neuroinfections, atrophic or senile processes;
vegetative-vascular dystonia.

Mexiprim injection solution is also used for circulatory disorders of the brain (acute forms), for cognitive disorders caused by atherosclerotic genesis, and in addition, for dyscirculatory encephalopathy.

Instructions for use Mexiprim

Tablets are administered orally. The therapeutic dose and duration of treatment are determined by the sensitivity of the patient to the drug. At the beginning of treatment, the drug is prescribed at a dose of 250-500 mg, the average daily dose is 250-500 mg, the maximum daily dose is 800 mg. The daily dose is divided into 2-3 doses during the day.

For the treatment of anxiety disorders, vegetative-vascular dystonia and cognitive impairment, the drug is used for 2-6 weeks. When stopping alcohol withdrawal syndrome, the duration of use is 5-7 days. Course therapy with Mexiprim is completed gradually, reducing the dose within 2-3 days.

Mexiprim injections are administered intramuscularly or intravenously(drip or jet method) 1-3 times a day. The dosage of the drug is set individually, taking into account the characteristics of each specific case. With the introduction of a solution for injection by the infusion method, the drug is diluted with sodium chloride. As a rule, the dosage of the first injections does not exceed 100 mg. In the future, the dose of the drug is gradually increased.

The duration of the therapeutic course of treatment with Mexiprim injection also depends on the patient's condition and the severity of the disease, it can last from 7 to 30 days.

See also: how to take a close analogue for vegetative-vascular dystonia -.

Contraindications

Before starting therapy with the drug, you should always consult with your doctor. The instructions indicate the following contraindications for use:

Age up to 18 years (due to the lack of clinical experience of use and data on the safety of the drug's effects on the child's body).
Individual hypersensitivity to the constituent components of the drug.
Severe liver dysfunction, acute and chronic liver failure.
Kidney dysfunction, acute and chronic renal failure.
The period of pregnancy and lactation.

Side effects

AT rare cases during therapy with Mexiprim, nausea, drowsiness, dryness of the oral mucosa, and hypersensitivity reactions may develop.

Children, during pregnancy and lactation

The use of the drug during pregnancy and lactation is contraindicated. Adequate and strictly controlled clinical studies of the safety of Mexiprim in children have not been conducted, so the drug should not be prescribed to this category of patients.

special instructions

Before using Mexiprim, you should consult with a specialist. During therapy, it is recommended to be careful when driving vehicles and performing other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

drug interaction

Mexiprim can be taken in combination with psychotropic drugs. The drug enhances the effectiveness of benzodiazepine anxiolytics, as well as anticonvulsant and antiparkinsonian drugs, such as carbamazepine and levodopa.

Mexiprim's analogs

According to the structure, analogues are determined:

Mexidol.
2-ethyl-6-methyl-3-hydroxypyridine succinate.
Mexidol solution for injections 5%.
Cerecard.
Meksidant.
Medomexi.
3-hydroxy-6-methyl-2-ethylpyridine succinate.
Mexicor.
Neurox.
Metostabil.
Mexipridol.
Ethylmethylhydroxypyridine succinate.
Meksifin.

Antihypoxants and antioxidants include analogues:

Thiogamma.
Kudesan Forte.
Valeocor Q10.
Angiosil retard.
Methylethylpyridinol.
Oksilik.
Olifen.
Rimecor.
Proxipin.
Actovegin.
Cytochrome C.
Trimectal.
Phenosanoic acid.
Laproth.
Vitanam.
Metaguard.
Emoxipin.
Trecrezan.
Trimetazidine.
Cardioxipin.
Kudesan.
Enerlit.
Ethoxydol.
Predizin.
Thiotriazoline.
Yantavit.
Ethylthiobenzimidazole hydrobromide.
Glation.
Carnitine.
Hypoxen.
Triducard.
Antisten.
Preductal MV.
Mitomin.
Confumin.
Histochrome.
Limontar.
Solcoseryl.
Precard.
Kudesan for children.
Preductal.
Levocarnitine.
Dimephosphon.
Kudevita.
Carnifit.
Mexidol.
Sodium hydroxybutyrate.
Deprenorm MV.

Holiday conditions and price

The average cost of Mexiprim (tablets 125 mg No. 30) in Moscow is 175 rubles. The price of injections is 342 rubles for 10 ampoules of 2 ml. Released by prescription.

It is necessary to store in a place protected from moisture and light; storage temperature: solution - up to 20 C, tablets - up to 30 C. Shelf life: solution - 3 years; tablets - 5 years.

Mexiprim is an antioxidant drug.

It is able to inhibit free oxygen species (formed during lipid peroxidation), stabilize and protect against cell membrane damage (reduces membrane viscosity and also increases its fluidity), and also has nootropic, anticonvulsant (mild), anxiolytic and anti-stress effects.

The drug increases the body's resistance to external damaging factors.

Clinical and pharmacological group

Antioxidant drug.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Mexiprim cost? The average price in pharmacies is at the level 190 rubles for tablets and 370 rubles for a solution.

Release form and composition

The drug is produced in the form of round tablets having a biconvex shape and coated with a specialized white or cream-colored shell, as well as in the form of a solution for injection, which is a clear, colorless or pale yellow liquid.

The solution intended for the preparation of injections is packaged in ampoules of 2 or 5 ml. in each and placed in contour cells. One carton may contain 20, 50 or 100 ampoules, complete with a special knife for opening them.

Composition of 1 ml solution:

active ingredient: ethylmethylhydroxypyridine succinate - 50 mg;
excipient: water for injection - up to 1 ml.

Composition of 1 tablet:

active ingredient: ethylmethylhydroxypyridine succinate in terms of 100% substance - 125 mg;
excipients: kaolin - 2.47 mg; calcium stearate - 2.75 mg; talc - 5.3 mg; sodium carboxymethyl starch - 12.58 mg; povidone - 13.4 mg; microcrystalline cellulose - 113.5 mg;
shell: talc - 0.37 mg; macrogol - 1.28 mg; titanium dioxide - 1.65 mg; hypromellose - 4.95 mg.

Pharmacological effect

Since the instruction refers to Mexiprim as a heteroaromatic antioxidant, it has a wide range of applications. The medicine increases the body's resistance to stressful situations. When using the drug, its anxiolytic properties are manifested, and without muscle relaxant effects or drowsiness.

The drug reduces and prevents the occurrence of memory and learning disorders, has a nootropic and anticonvulsant effect on elderly patients. Thanks to its antihypoxic and antioxidant abilities, Mexiprim helps to increase efficiency and concentration, and, in addition, minimizes the harmful toxic effects of alcoholic beverages.

The tool has a positive effect on the brain tissue, as well as the circulatory system of the body by stimulating blood microcirculation and platelet aggregation. The drug lowers cholesterol levels due to its pronounced lipid-lowering abilities. When it enters the human body, the drug is rapidly metabolized and transformed into glucuron-conjugated degradation products.

Indications for use

The tablet form is prescribed for:

Intellectual deficiency in gerontology;
Stressful influences;
Anxious states against the background of neuroses, neurosis-like states;
cognitive disorders;
Alcohol withdrawal with vegetovascular manifestations.

The injection form is prescribed for:

Alcohol withdrawal syndrome;
Discirculatory encephalopathy;
Intoxication with antipsychotic drugs;
Acute disorders of cerebral circulation;
Neurocirculatory dystonia;
Cognitive disorders on the background of atherosclerosis;
Anxiety states of moderate severity on the background of neurological disorders;
Acute purulent-inflammatory pathologies of the abdominal cavity.

Contraindications

Before starting therapy with the drug, you should always consult with your doctor. The instructions indicate the following contraindications for use:

The period of pregnancy and lactation;
Individual hypersensitivity to the constituent components of the drug;
Severe liver dysfunction, acute and chronic liver failure;
Disturbances in the work of the kidneys, acute and chronic renal failure;
Age up to 18 years (due to the lack of clinical experience of use and data on the safety of the drug's effects on the child's body).

Use during pregnancy and lactation

Mexiprim is contraindicated in pregnant and lactating women, since the safety and possibility of its use in this category of patients have not been studied enough.

Dosage and method of application

The instructions for use indicate that Mexiprim tablets are prescribed orally. The therapeutic dose and duration of treatment are determined by the sensitivity of the patient to the drug.

At the beginning of treatment, the drug is prescribed at a dose of 250-500 mg, the average daily dose is 250-500 mg, the maximum daily dose is 800 mg. The daily dose is divided into 2-3 doses during the day.

For the treatment of anxiety disorders, vegetative-vascular dystonia and cognitive impairment, the drug is used for 2-6 weeks.

When stopping alcohol withdrawal syndrome, the duration of use is 5-7 days.

Course therapy with Mexiprim is completed gradually, reducing the dose within 2-3 days.

Solution - instruction

Mexiprim is administered intramuscularly or intravenously (by jet or drip). To prepare a solution for infusion, the drug should be diluted with isotonic sodium chloride solution.

Doses are selected individually depending on the pathology and severity of the patient's condition. The initial dose is 50-100 mg 1-3 times / day. In the future, it is possible to increase the dose to obtain a therapeutic effect. The maximum daily dose is 800 mg.

Jet Mexiprim is injected slowly, over 5-7 minutes, drip - at a rate of 40-60 drops / min.

In acute intoxication with antipsychotics, the drug is administered intravenously at a dose of 50-300 mg / day for 7-14 days.
For mild cognitive impairment in elderly patients and for anxiety disorders, the drug is used intramuscularly at a daily dose of 100-300 mg for 14-30 days.
In the treatment of acute cerebrovascular accidents, Mexiprim is used in complex therapy in the first 2-4 days of intravenous drip at a dose of 200-300 mg 1 time / day, then IM 100 mg 3 times / day. The duration of treatment is 10-14 days.
With alcohol withdrawal syndrome, Mexiprim is administered at a dose of 100-200 mg intramuscularly 2-3 times / day or intravenously drip 1-2 times / day for 5-7 days.
With dyscirculatory encephalopathy in the decompensation phase, Mexiprim should be administered intravenously in a stream or drip at a dose of 100 mg 2-3 times / day for 14 days. Then the drug is administered intramuscularly at 100 mg / day for the next 2 weeks. For course prevention of dyscirculatory encephalopathy, the drug is administered intramuscularly at a dose of 100 mg 2 times / day for 10-14 days.

Side effects

In rare cases, when using Mexiprim, the following side effects occur: dryness of the oral mucosa, nausea, allergic reactions, increased drowsiness.

Overdose

Symptoms: sleep disturbance (insomnia, in some cases - drowsiness).

Treatment, as a rule, is not required, the symptoms disappear on their own within a day. In severe cases of insomnia, it is recommended to take nitrazepam 10 mg, oxazepam 10 mg or diazepam 5 mg.

Detoxification therapy is also used.

special instructions

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

drug interaction

With the simultaneous use of Mexiprim enhances the action of anxiolytics from the benzodiazepine group, antiparkinsonian (levodopa) and anticonvulsants (carbamazepine).

Mexiprim reduces the toxic effects of ethanol.