The best hepatoprotectors with proven effectiveness. What hepatoprotectors of the new generation to take - a list of drugs Hepatotropic drugs list

The list of hepatoprotective drugs with proven effectiveness cannot be called extensive. Pharmacies sell more than 700 types of hepatoprotectors of various origins. The protective and therapeutic effect of most of them is confirmed only by a subjective parameter - an improvement in well-being. Only a few drugs have passed a controlled study (, suppression). Among them are products with ursodeoxycholic acid and an extract from milk thistle.

Indications for the use of liver protector drugs

Hepatoprotectors with proven clinical efficacy help with various liver diseases. They are prescribed:

• against cirrhosis caused by a virus;
• against alcohol;
• for treatment (impaired outflow of bile into the intestines);
• after chemotherapy, s;
• with (hepatoprotectors normalize the work of the biliary system);
• at a liver against a diabetes mellitus.

Classification of hepatoprotectors

Clinical pharmacology allows you to understand which drug can be called the most effective. Since the existing hepatoprotectors for the liver only partially meet the requirements put forward by Professor R. Preisig (1970), none of them can be called ideal. Hepatoprotectors are classified into groups based on their origin and chemical structure.

List of essential phospholipids

The preparations are made from highly purified extract of soybeans. The essential phospholipids included in soy restore liver cells (hepatocytes), maintain their structure and participate in the transport of protein molecules through cell membranes. Today, the effectiveness of the following drugs has been proven:

• Essentiale forte H. The hepatoprotector is sold in capsules or in the form of a liquid for injection (prescribed in severe cases). Recommended for viral and. The drug prevents narrowing of the biliary tract. The drug is contraindicated in children under 12 years of age.
• Essel forte. The drug is enriched with vitamins B and E. It is effective in various diseases of the digestive gland and its. A hepatoprotector is available in tablets.
• Resolution Pro. Sold in capsules of 30, 50 and 100 pieces per pack. It is prescribed for toxic poisoning, cirrhosis and fatty degeneration of the liver.

The duration of treatment with any essential phospholipid is individual. The daily adult dose is 6 capsules.

List of amino acid hepatoprotectors

Preparations with aminocarboxylic acids may contain:

• Ademetionine (Heptral, Heptor). The amino acid stimulates the production of phospholipids in the body, provides liver cells with a regenerating and detoxifying effect. Heptral and Heptor are administered intravenously for severe pathologies and are prescribed in tablets for moderate diseases. Drugs are considered hepatoprotectors that help maintain the overall health of the body (improve metabolic processes, improve the quality of blood composition, promote the outflow of bile into the intestines) in chronic.
• Ornithine aspartate (Hepa-merz, Larnamin) - an amino acid helps to cope with hyperammonemia (poisoning of the body with ammonia, urea enzyme), which is a consequence of liver intoxication. Preparations containing ornithine aspartate are expensive, which is why they are rarely prescribed for prevention purposes. Release form Hepa-merz - granular powder for oral solution, Larnamin - liquid for injection in ampoules, granular powder in sachets.

Therapy with extracts from the liver of animals

Any hepatoprotector based on animal components should be purchased only with a doctor's prescription.

Inexpensive drugs:

• Hepatosan - contains an extract from the liver cells of pigs. It has a therapeutic effect in fatty hepatosis and non-infectious cirrhosis. It is taken for two weeks, 2 capsules three times a day.
• Sirepar is an analogue of Hepatosan, enriched with vitamin B12, which contributes to normal hematopoiesis. Available in the form of a solution for intravenous administration.
• Prohepar - contains bovine liver extract. It is prescribed for any lesions of the gland, with the exception of -. It is sold in tablets that take 1-2 pcs. 3 times a day for 2-3 months.

Modern hepatoprotectors with bile acids

They are made using chenodeoxycholic and ursodeoxycholic acid. The first gives a lot of side effects (nausea, biliary colic, allergies, diarrhea). Contained in the preparations Henofalk, Henosan, Henohol. They are taken to destroy cholesterol.

According to doctors, the most effective hepatoprotector is the one made using ursodeoxycholic acid:

• Ursosan;
• Ursodez;
• Ursofalk;
• Livodex;
• Ursoliv and others.

Preparations with UDCA are indicated for the relief of symptoms of biliary cirrhosis, for the treatment of acute hepatitis, and drug-induced liver damage. The dosage and duration of therapy is individual. Due to the strong choleretic effect of bile acid, these drugs are not prescribed to patients with large ones.

Plant-based preparations of natural origin

Commonly prescribed herbal hepatoprotectors:

• Gepabene;
• Geparsil;
• Karsil;
• Legalon;
• Silibor;
• Silimar.

These preparations are made using silymarin (the active substance of the extract). Its hepatoprotective properties help restore the liver affected by acute or chronic hepatitis, cirrhosis. To solve the problem of gland health, it should be taken for at least three months in a row.

Hepatoprotectors of plant origin also include preparations containing artichoke extract. They are sold in tablet form and gelatin capsules:

• Hofitol;
• Holiver;
• Febihol.

The duration of administration and dosage of hepatoprotectors is recommended by the attending physician, taking into account the type and severity of the disease.

Combined medicines for the gallbladder and liver

List of new and known hepatoprotectors of the combined type (contain substances from different pharmacological groups):

• Sirin - the drug includes methionine, artichoke extract, milk thistle, Chinese magnolia vine and other plants. The drug is drunk for 30-45 days, 1-2 tablets. morning and evening after meals.
• Gepadif - a hepatoprotector is prescribed for alcoholic, drug and infectious intoxication of the liver. Contains two amino acids (adenine, carnitine), enriched with B vitamins. Available in capsules (daily dose of 4-6 pieces) and powder for infusion. Treatment can last two or more months.
• Eslidine - contains the amino acid methionine and phospholipids. Sold in capsules. Accept 2 pcs. three times a day for 1-3 months in a row.
• Detoxil - made from extracts of artichoke, grapefruit, dandelion and methionine. The drug is fortified (vit. A, E, C, B). It is sold in tablets. Take a month for 1-2 pcs. in a day.

Dietary supplements and homeopathic medicines

Products and herbs-hepatoprotectors

• seaweed;
• pumpkin pulp;
• low-fat dairy products;
• dried apricots, prunes, raisins;
• olives, olive oil;
• meat and fish of dietary varieties;
• oatmeal, millet, buckwheat.

Lifestyle

It is important for people with a diseased liver to lead an active lifestyle, but at the same time, the body should not be subjected to heavy loads. In a person who does not move much, the processing of animal fats slows down. They are deposited in hepatocytes, which can provoke. The same thing happens with the liver of people who periodically exercise intensively, for example, in order to lose weight. For a quick recovery, doctors recommend daily hour-long walks in the fresh air. Smokers should give up bad habits.

Literature

• Cherenkov, V. G. Clinical oncology: textbook. allowance for the postgraduate system. education of doctors / V. G. Cherenkov. – Ed. 3rd, rev. and additional - M.: MK, 2010. - 434 p.: ill., tab.
• Ilchenko A.A. Diseases of the gallbladder and biliary tract: A guide for physicians. - 2nd ed., revised. and additional - M .: LLC "Publishing House" Medical Information Agency ", 2011. - 880 p.: ill.
• Tukhtaeva N. S. Biochemistry of biliary sludge: Dissertation for the degree of candidate of medical sciences / Institute of Gastroenterology of the Academy of Sciences of the Republic of Tajikistan. Dushanbe, 2005
• Litovsky, I. A. Cholelithiasis, cholecystitis and some diseases associated with them (issues of pathogenesis, diagnosis, treatment) / I. A. Litovsky, A. V. Gordienko. - St. Petersburg: SpetsLit, 2019. - 358 p.
• Dietology / Ed. A. Yu. Baranovsky - Ed. 5th - St. Petersburg: Peter, 2017. - 1104 p.: ill. - (Series "Doctor's Companion")
• Podymova, S.D. Liver Diseases: A Guide for Physicians / S.D. Podymov. - Ed. 5th, revised. and additional - Moscow: Medical Information Agency LLC, 2018. - 984 p.: ill.
• Schiff, Eugene R. Introduction to Hepatology / Eugene R. Schiff, Michael F. Sorrel, Willis S. Maddrey; per. from English. ed. V. T. Ivashkina, A. O. Bueverova, M.V. Maevskaya. - M.: GEOTAR-Media, 2011. - 704 p. - (Series "Liver diseases according to Schiff").
• Radchenko, V.G. Fundamentals of clinical hepatology. Diseases of the liver and biliary system. - St. Petersburg: Dialect Publishing House; M .: "Publishing house BINOM", - 2005. - 864 p.: ill.
• Gastroenterology: Handbook / Ed. A.Yu. Baranovsky. - St. Petersburg: Peter, 2011. - 512 p.: ill. - (Series "National Medical Library").
• Lutai, A.V. Diagnosis, differential diagnosis and treatment of diseases of the digestive system: Textbook / A.V. Lutai, I.E. Mishina, A.A. Gudukhin, L.Ya. Kornilov, S.L. Arkhipova, R.B. Orlov, O.N. Aleutian. - Ivanovo, 2008. - 156 p.
• Akhmedov, V.A. Practical Gastroenterology: A Guide for Physicians. - Moscow: LLC "Medical Information Agency", 2011. - 416 p.
• Internal diseases: gastroenterology: Textbook for classroom work of 6th year students in the specialty 060101 - general medicine / compiled by: Nikolaeva L.V., Khendogina V.T., Putintseva I.V. – Krasnoyarsk: type. KrasGMU, 2010. - 175 p.
• Radiology (radiation diagnostics and radiation therapy). Ed. M.N. Tkachenko. - K .: Book-plus, 2013. - 744 p.
• Illarionov, V.E., Simonenko, V.B. Modern methods of physiotherapy: A guide for general practitioners (family doctors). - M .: OJSC "Publishing House" Medicine "", 2007. - 176 p.: ill.
• Schiff, Eugene R. Alcoholic, drug, genetic and metabolic diseases / Eugene R. Schiff, Michael F. Sorrel, Willis S. Maddray: trans. from English. ed. N. A. Mukhina, D.T. Abdurakhmanova, E.Z. Burnevich, T.N. Lopatkina, E.L. Tanashchuk. - M.: GEOTAR-Media, 2011. - 480 p. - (Series "Liver diseases according to Schiff").
• Schiff, Eugene R. Cirrhosis of the liver and its complications. Liver transplantation / Eugene R. Schiff, Michael F. Sorrel, Willis S. Maddrey: trans. from English. ed. V.T. Ivashkina, S.V. Gotye, Ya.G. Moisyuk, M.V. Maevskaya. – M.: GEOTAR-Media, 201st. – 592 p. - (Series "Liver diseases according to Schiff").
• Pathological physiology: Textbook for medical students. universities / N.N. Zaiko, Yu.V. Byts, A.V. Ataman and others; Ed. N.N. Zaiko and Yu.V. Bytsya. - 3rd ed., revised. and additional - K .: "Logos", 1996. - 644 p.; ill.128.
• Frolov V.A., Drozdova G.A., Kazanskaya T.A., Bilibin D.P. Demurov E.A. pathological physiology. - M .: JSC "Publishing House" Economics ", 1999. - 616 p.
• Mikhailov, V.V. Fundamentals of Pathological Physiology: A Guide for Physicians. - M.: Medicine, 2001. - 704 p.
• Internal Medicine: Textbook in 3 volumes - Vol. 1 / E.N. Amosova, O. Ya. Babak, V.N. Zaitsev and others; Ed. prof. E.N. Amosova. - K .: Medicine, 2008. - 1064 p. + 10 s. col. incl.
• Gaivoronsky, I.V., Nichiporuk, G.I. Functional anatomy of the digestive system (structure, blood supply, innervation, lymphatic drainage). Tutorial. - St. Petersburg: Elbi-SPb, 2008. - 76 p.
• Surgical diseases: Textbook. / Ed. M. I. Kuzina. – M.: GEOTAR-Media, 2018. – 992 p.
• Surgical diseases. Guidelines for the examination of the patient: Textbook / Chernousov A.F. etc. - M.: Practical medicine, 2016. - 288 p.
• Alexander J.F., Lischner M.N., Galambos J.T. Natural history of alcoholic hepatitis. 2. The long term prognosis // Amer. J. Gastroenterol. - 1971. - Vol. 56. – P. 515-525
• Deryabina N.V., Ailamazyan E.K., Voinov V.A. Cholestatic hepatosis of pregnant women: pathogenesis, clinic, treatment // Zh. and wives. disease. 2003. No. 1.
• Pazzi P., Scagliarini R., Sighinolfi D. et al. Nonsteroidal antiinflammatory drug use and gallstone disease prevalence: a case-control study // Amer. J. Gastroenterol. - 1998. - Vol. 93. – P. 1420–1424.
• Marakhovsky Yu.Kh. Gallstone disease: on the way to the diagnosis of early stages // Ros. magazine gastroenterol., hepatol., coloproctol. - 1994. - T. IV, No. 4. - P. 6–25.
• Higashijima H., Ichimiya H., Nakano T. et al. Deconjugation of bilirubin accelerates coprecipitation of cholesterol, fatty acids, and mucin in human bile–in vitro study // J. Gastroenterol. - 1996. - Vol. 31. – P. 828–835
• Sherlock S., Dooley J. Diseases of the liver and biliary tract: Per. from English. / Ed. Z.G. Aprosina, N.A. Mukhin. - M.: GEOTAR Medicine, 1999. - 860 p.
• Dadvani S.A., Vetshev P.S., Shulutko A.M., Prudkov M.I. Cholelithiasis. – M.: Ed. house "Vidar-M", 2000. - 150 p.
• Yakovenko E.P., Grigoriev P.Ya. Chronic liver diseases: diagnosis and treatment // Rus. honey. zhur. - 2003. - T. 11. - No. 5. - P. 291.
• Sadov, Alexey Cleansing the liver and kidneys. Modern and traditional methods. - St. Petersburg: Peter, 2012. - 160 p.: ill.
• Nikitin I.G., Kuznetsov S.L., Storozhakov G.I., Petrenko N.V. Long-term results of interferon therapy for acute HCV hepatitis. // Ross. magazine gastroenterology, hepatology, coloproctology. - 1999, vol. IX, No. 1. - p. 50-53.

Medicines for the liver are hepatoprotectors that are prescribed by a doctor for various violations of liver function, hepatitis (viral, toxic,), with liver damage when taking drugs that have a negative effect on its cells (antitumor, painkillers, anti-tuberculosis drugs, broad-spectrum antibiotics , and etc).

What medicine for the liver is considered the best, good, effective and not expensive? What drug restores the liver, is used for prevention, to maintain the liver? To date, the pharmaceutical industry offers a lot of pills, ostensibly to restore the liver:

• amino acid derivatives
• phospholipids
• bile acids
• herbal remedies
• preparations of animal origin
• homeopathic preparations

but the ideal medicine for the treatment of the liver, which quickly and effectively restores its tissues, has not yet been created. According to the doctor's prescription, hepatoprotectors are taken during the entire adverse effect of provoking factors, as well as after the end of their influence. It should be noted that a one-time medication for the liver after alcohol, heavy feast, overeating, taking toxic drugs does not give any effect.

When are hepatoprotectors needed?

In Russia, a huge selection of hepatoprotectors is presented, and these drugs are used very often. Moreover, the cost of the course of treatment costs large sums for patients, and many do not feel the result. Disputes about the need and expediency of such therapy have been going on for a long time, in our country a doctor can prescribe hepatroprotectors in the following cases:

• Viral hepatitis(see) - they are prescribed if antiviral drugs do not help or, for some reason, antiviral treatment is not possible. Hepatoprotectors in this case can be used for prophylaxis in complex treatment.
• Alcoholic hepatitis threatened by cirrhosis of the liver- in this case, alcohol should be abandoned, these drugs do not have a significant effect. If alcohol intake continues, whether the patient uses hepatoprotectors or not is not important. No, even the best medicines for the liver will not help if a person continues to drink alcohol.
• Fatty liver disease (non-alcoholic)- in patients with obesity or in patients with type 2 diabetes, fat cells are also formed in the liver, which leads to its destruction (see). In this case, hepatoprotectors are needed to accelerate the effect only with an integrated approach to therapy - a diet that promotes weight loss, increased physical activity, antidiabetic drugs, lowering cholesterol (see).
• Drug-induced hepatitis (toxic), primary biliary cirrhosis- certain hepatoprotectors are prescribed in complex therapy.

It should be understood that it is impossible to restore the liver with drugs alone, you should also follow a diet and limit alcohol intake, quit smoking, and treat concomitant diseases, since the patient often has impaired functions of other organs involved in digestion - the gallbladder, pancreas.

Why are hepatoprotectors as a class of medicines available only in Russia and the CIS countries?

The class of drugs "hepatoprotectors" exists only in Russia and the CIS countries, neither in Europe, nor in North America, nor in Australia, most of them are registered. They are not included in the lists of tablets for the treatment of liver diseases due to the fact that their therapeutic efficacy has not been proven and clinical significance has not been confirmed.

Very rarely, some of them are used in the USA and Europe for narrow indications, they are used as dietary supplements (that is, their use does not guarantee an effect). The French company Sanofi, one of the manufacturers of Essentiale, sends 99% of its production to Russia and the CIS countries, since no one in the world needs this drug.

It is worth noting that the pharmaceutical market in the 21st century is a very profitable business, in which there is the same fierce competition as in any branch of the market economy. And today it is very difficult to determine how effective this or that drug is, since research (very expensive) is funded by interested parties.

Preparations for the liver - essential phospholipids

• fatty degeneration of the liver
• liver cirrhosis
• chronic hepatitis
• toxic hepatitis
• alcoholic hepatitis (see)
• radiation syndrome

Is it really? Below we will give two points of view, one - these instructions for essential phospholipids and known efficacy studies, and the other - other information about studies that contradict the advertising campaign of this group of drugs.

positive opinion- What does the instruction for the use of these capsules say? Essential phospholipids (derived from soy) are components of the cell wall of hepatocytes. The action of phospholipids is that they penetrate into the lipid layer of the walls of damaged cells, improving their functions.

Many believe that essential phospholipids are able to restore liver cells, this is not entirely true, since their action only improves the condition of cell walls. When taking phospholipids, the energy costs of the liver are reduced, enzyme activity is increased, and the physicochemical properties of bile are improved. To obtain a tangible result, these tablets should be taken for a very long time (up to six months). The greatest effect is achieved with intravenous administration of Essentiale Forte.

By the end of 2001, there were 186 clinical trials, including more than 11,000 patients, which allow us to draw conclusions about the effectiveness of these drugs. Essential phospholipids increase the likelihood of a response to α-interferon (c), are well tolerated by patients, and reduce the frequency of relapses after completion of α-interferon therapy.

negative opinion- Initially, it was assumed that essential phospholipids are effective as a "drug cover" when taking hepatotoxic drugs, with alcoholic, viral hepatitis and liver steatosis of various origins.

However, a 2003 US study of veteran medical centers, did not reveal any positive effect of these drugs on liver function. In addition, it was found that against the background of viral hepatitis, both acute and chronic, the intake of essential phospholipids contributed to the activation of inflammation, as it provoked bile stasis. Based on these studies, their use in the treatment of viral hepatitis is not advisable.

Moreover, it is known that various B vitamins that are added to some products (Essliver Forte) are not recommended to be taken at the same time (see). According to some sources, liver pills like Essentiale hardly get into the liver, but are distributed and metabolized throughout the body, which casts doubt on their effectiveness. But the cost of treatment with these drugs is very high - only for a monthly course of treatment (in capsules) an adult needs more than 3,000 rubles.

Conclusion: Now in clinical practice, essential phospholipids are widely used in non-alcoholic steatohepatitis, toxic liver damage, as a cover when taking hepatotoxic drugs, but the effectiveness remains in doubt. In addition, with active hepatitis, their use requires caution, or refusal to use, since this can enhance the activity of the process and increase cholestasis.

List of essential phospholipids

Essentiale N, Essentiale forte N Ingredients: essential phospholipids. Side effects: well tolerated, sometimes diarrhea, abdominal discomfort. Contraindicated in children under 12 years of age. Average price in pharmacies 2018: 30 pcs. 660 rubles, 5 amp. 950 rub. 90 pcs. 1300 rub.

Essliver Forte Ingredients: essential phospholipids (less than in Essential), vitamins (B1, B2, B6, E, PP, B12) Side effects: possible diarrhea, pain in the upper abdomen With caution in children under 1 2 years old, pregnant, lactating. Price: 30 caps. 300 rubles, 50 caps. 420 rub.

Ingredients: Lipoid C100 and Silymarin () Price: 30 caps. 420-480 rub.

Gepaguard Active Ingredients: essential phospholipids, vitamin E Price: 30 caps. 300 rubles, 120 caps. 900-950 rubles.

Ingredients: phospholipids, trisodium salt of glycyrrhizic acid (antiviral and immunomodulating effect) Price: 50 caps. 450-500 rub. powder for injections 5 pcs. 1300-1500 rub.

Resolution PRO Ingredients: Lipoid PPL 600, which contains: medium chain triglycerides, phospholipids, glycerol mono/dialconate, soybean oil, vitamin E. Price: 30 caps. 450 rubles, 100 caps. 1300 rub.

Doppelherz active essential phospholipids Compound: Essential phospholipids, Vitamin B1, B2, B6 Price: 60 caps. 460 rubles, 5 amp. 640 rub.

Eslidine Composition: phospholipids + methionine Indicated: For liver diseases, diabetes mellitus, psoriasis, dystrophy and exhaustion, atherosclerosis of the coronary arteries and brain vessels . Contraindicated: children under 3 years of age, pregnant and lactating with caution. Price: 580 -720 rubles.

Tablets - bile acids

Ursodeoxycholic acid is a bile acid preparation. It is used for the treatment of diseases of the biliary tract and liver, uncomplicated cholelithiasis. It has a hypoglycemic effect, choleretic, therefore it is contraindicated in the presence of X-ray-positive (high in calcium) gallstones (see also), reduces the saturation of bile with cholesterol (until cholesterol stones are completely dissolved), causes an increase in pancreatic and gastric secretion. Affects immunological reactions in the liver - reduces, affects the formation of interleukin-2, the number of T-lymphocytes.

Since drugs containing ursodeoxycholic acid have a number of serious contraindications (acute inflammatory processes in the intestines, gallbladder, severe dysfunction of the pancreas, kidneys and liver, gallstones), and also have an immunomodulatory effect, their use without a doctor's recommendation is dangerous.

These drugs are used for:

• biliary reflux gastritis,
• for symptomatic treatment of primary biliary cirrhosis,
• to dissolve cholesterol stones in the gallbladder,
• alcohol, toxic liver damage,
• acute hepatitis, with hepatopathy of pregnant women.
• UDCA is the most effective treatment for primary biliary cirrhosis, primary sclerosing cholangitis.

Pathogenetic therapy with ursodeoxycholic acid is carried out in patients with viral hepatitis with aggravating factors - during pregnancy, alcoholic-viral liver damage, hemophilia, in adolescence, with oncohematological diseases, drug and substance abuse.

10 caps. 250 rub, 50 caps. 1000 rub. 100 caps. 1800 rub, susp. 1200 r.	Exhol 10 pcs 200 rub 100 pieces. 1500	Urosliv 10 caps. 160 rubles, 100 caps.1300 rub.	100 caps. 1100 rub.
Grinterol 50 pcs. 700 rub 100 pcs 1400 rub.	100 caps. 1200 rub.	50 pcs.300 rub. 100 pieces. 900r.	10 caps. 200 rub. 100 caps. 1500 rub.

Tablets for the liver of animal origin

Positive opinion: There are literally two such tablets for the liver - Sirepar and Hepatosan, they are not used for prevention, they are dispensed by prescription, are used only for the treatment of liver diseases according to indications (cirrhosis, hepatitis, drug-induced and toxic hepatitis). They are produced from pig liver cells (Hepatosan) and from cattle liver hydrolyzate (Sirepar), contain amino acids, cyanocobalamin, low molecular weight metabolites and fragments of liver growth factors. It is believed that these tablets for the liver have a hepatoprotective effect, detoxifying, antioxidant properties, stimulate the regeneration of the liver parenchyma.

There is also a complex preparation Prohepar (composition: inositol, cyanocobalamin, liver extract KPC N (liver hydrolyzate), cysteine ​​hydrochloride), improves blood flow in the liver tissue, restores the structure of hepatocytes, stops the formation of connective tissue in the liver, improves functional indicators of liver function, increases diuresis . It is used in the complex treatment of chronic hepatitis, cirrhosis, fatty degeneration of the liver, radiation sickness, drug intoxication.

Negative opinion: There is no evidence base to support their clinical efficacy and safety. Moreover, taking these drugs is potentially dangerous:

• It is impossible to prescribe them to patients with active forms of hepatitis, since the phenomena of immunopathological, mesenchymal-inflammatory and cytolytic syndromes may increase.
• These drugs have a high allergenic potential, therefore, before starting treatment, it should be determined whether there is an increased individual sensitivity to the drug.
• The use of bovine liver hydrolysates increases the risk of a patient becoming infected with a prion infection that causes spongiform encephalopathy (a fatal neurodegenerative disease - Creutzfeldt-Jakob disease). At the end of the 20th century, interest in this pathology arose when iatrogenic transmission of prions was proven in 250 patients with spongiform encephalopathy when contaminated gonadotropin was administered.

Due to the potential danger and unproven efficacy, drugs of this group are not advisable to use for the treatment of liver pathologies.

Treatment of the liver with amino acids

Ademetionine - Heptral, Heptor

positive opinion– Amino acids, for example, ademetionine, take part in the synthesis of biologically active substances and phospholipids, have regenerating and detoxifying properties. Heptral by the end of 1 week of use also exhibits a pronounced antidepressant effect, breaks down fats and promotes their removal from the liver. These drugs are used for fatty liver hepatosis (fatty degeneration), chronic hepatitis, toxic hepatitis, withdrawal symptoms, and depression.

The analysis of the conducted clinical studies indicates the clinical efficacy of ademetionine and indicates a pronounced hepatoprotective efficacy in alcoholic and drug-induced liver damage, cholestatic liver diseases (primary biliary cirrhosis), and chronic viral hepatitis. It has choleretic and cholekinetic effects, antioxidant, neuroprotective and antifibrosing properties.

negative opinion- as a drug Heptral is registered in Germany, Italy, Russia. In Australia, it is registered as a drug for animals (veterinary), in other countries, as a dietary supplement, since studies have shown a dubious effect.

Practicing doctors - gastroenterologists, infectious disease specialists, hepatologists know that this drug very effective, but only with intravenous infusions, since only a small part of the drug is absorbed when taken orally. Therefore, Heptral in tablets with serious liver pathology is an almost useless waste of money, in contrast to intravenous use.

Ingredients: active ingredient ademetionine It has an antidepressant, regenerating, antioxidant effect. Slows down the development of cirrhosis of the liver. Side effects: may be heartburn, stomach pain. Price: 20 tab. or 5 fl. 1700 -1800 rub.

Ingredients: active substance ademetionine As well as Heptral is indicated for toxic liver damage, depression, cirrhosis of the liver, treatment of the consequences of alcohol abuse. Contraindicated: children, lactation and in the I and II trimester of pregnancy. Price: 20 tab. 800-1000 rubles, 5 fl. 1200 rub.

Ornithine aspartate - Hepa-Merz

positive opinion- Ornithine helps to reduce high levels of ammonia, is used for violations of brain functions associated with impaired liver function, as well as for fatty degeneration and toxic hepatitis. For prevention, this medicine is practically not used.

The effectiveness of Hepa-Merz has been proven in a randomized multicenter study in patients with cirrhosis of the liver with elevated levels of ammonia in the blood. It is prescribed for various types of hepatitis, non-alcoholic steatohepatitis, especially for hepatic encephalopathy and cirrhosis of the liver.

negative opinion- this drug was widely advertised, but with alcoholic liver damage it has practically no effect, it makes no sense to use it for the prevention, protection, restoration of the liver. The only time when its use gives a tangible effect is with a hepatic coma for a short-term exit from it, since ornithine binds components toxic to the brain in the blood.

Thioctic acid

Action: normalizes lipid, energy, carbohydrate metabolism, has hepatoprotective, antioxidant properties. Helps reduce blood glucose levels, is used in the complex treatment of hepatitis and toxic liver damage.
Contraindications: children, can lead to a sharp decrease in blood glucose levels (especially in diabetics).
Side effects: nausea, vomiting, diarrhea, pruritus, headache.

Complex hepatoprotector - Remaxol, infusion solution

Prevention of the hepatotoxic effect of alcohol

Medicines for the liver of plant origin

Medicines for the liver with milk thistle - Legalon, Karsil, Gepabene, Silimar

Positive opinion:- these drugs are widely used and really effective (see). When asked which medicine is best for the liver, the answer is milk thistle preparations. Silymarin is the collective name for the biologically active substances of the fruits of milk thistle, is a strong antioxidant (and the only antidote for poisoning with pale toadstool). According to the indications, it is prescribed for hepatitis and other liver diseases with a course of at least 3 months, helps to reduce the intensity of the progression of liver cirrhosis. Preparations with the active ingredient silymarin are a good medicine for recovery, maintenance of the liver, as it stimulates the growth of new cells and restores the destruction of cell membranes.

For more effective treatment, it is better not to save money, but to take Legalon with a purer chemical substance and a higher dosage (70 and 140 mg) or Karsil Forte (90 mg) than simple Karsil (35 mg).

In pharmacy chains, there is a fairly wide selection of preparations with milk thistle, both medicines and dietary supplements. Among the analogues of Karsil, one can single out Silimar tab., Legalon, Silibinin, Silymarin, among dietary supplements - milk thistle meal, milk thistle oil, capsules.

negative opinion: Despite the safety of this agent, the clinical efficacy of silymarin in alcoholic liver damage and acute hepatitis has not been confirmed due to a lack of adequate studies. In acute viral hepatitis B, there was no improvement in liver function between the placebo and silymarin groups (see). Data on the effectiveness of its use in acute hepatitis C have not yet been obtained, there are only descriptions of individual cases when milk thistle extract reduced the activity of aminotransferases in chronic hepatitis C. Summarizing today's data from evidence-based medicine on its effectiveness, we can state that today experimental data to recommend further study of the effectiveness of silymarin in chronic liver diseases (including fatty liver).

Karsil (35mg) and Karsil Forte (90mg) Ingredients: milk thistle extract. Application: before meals, drinking plenty of water, the course is at least 3 months. For prevention, 1 tablet 3 r / day. For children over 12 years old and adults with severe liver damage, 4 others 3 r / day, then 1-2 dr 3 r / day. Side effects Karsil 80 pcs. 330 rub., Karsil Forte 30 pcs. 380 rub.

Ingredients: milk thistle fruit extract. Application: after eating, without chewing, drinking a small amount of liquid. The beginning of treatment for 2 caps. 3 r/day, maintenance therapy 1 dr. 3 r/day. Side effects: allergic reactions, diarrhea. Legalon 70 mg: 30 caps. 230 rub. 60 caps. 400 rub Legalon 140 mg: 30 caps - 340 rubles, 60 caps. 600 rub.

Gepabene (milk thistle and fumes) Ingredients: herbs of fume medicinal dry extract and milk thistle. Contraindication: children under 18 years old, acute inflammation of the liver and biliary tract. Application: 1 caps. 3 r / d. In case of pain syndrome, additionally take 1 more caps. before bedtime. The maximum daily dose is 6 capsules, taken in 3-4 doses. Price: 30 caps. 430-570 rub.

Silimar tablets Ingredients: milk thistle fruit extract. Application: with toxic liver damage, cirrhosis, after hepatitis, chronic hepatitis, with prolonged use of alcohol and drugs, with intoxication. 1-2 tab. 3 r / d in 30 min. before meals. The course is 25-30 days. After 1-3 months, you can repeat the treatment. Not recommended children under 12 years old. Side effects: loosening of the stool and allergic reactions are possible. Price: 30 pcs. 110-150 rub.

Milk thistle tablets (extract) Ingredients: 50 mg silymarin. Application, indications, contraindications and side effects the same as in other preparations with milk thistle extract. Price: 20 pcs. 130 rub.

Milk thistle meal (ground plant) Application: 1 teaspoon 3 r / day with meals. Contraindications: cholelithiasis, exacerbation of gastric and duodenal ulcers, hypersensitivity, pregnant, lactating women. Side effects: pain in the right hypochondrium, diarrhea, allergy. Price: 60 rubles.

Milk thistle oil capsules Application: adults 1 caps. 2 r / d during meals. The course is 1 month, which can be repeated 2-3 times a year. Contraindications Key words: acute gastrointestinal diseases, childhood. Price: 40-60 rubles

milk thistle syrup Ingredients: meal and milk thistle extract, common thyme herb, common tansy flowers. Application: 1 tbsp. spoon 1-2 r / d during meals. Course 4-6 weeks. It is possible to repeat the course up to 4 times a year. Contraindications: children under 14, pregnancy, lactation, diabetes mellitus. Price: 150 ml. 110 rub.

Artichoke is a plant used to treat the liver

positive opinion: Artichoke is a plant that has been used in folk medicine since ancient times to reduce joint pain, to treat jaundice, as it improves metabolism, helps reduce bad cholesterol, has a diuretic, choleretic and hepatoprotective effect. In artichoke preparations, the main active ingredient is cymarin, similar in properties to silibinin. Among preparations with artichoke, Hofitol can be distinguished, among dietary supplements - Cynarix, Artichoke Extract. They are used to relieve alcohol intoxication, for the treatment of cholecystitis, hepatitis,. The drug has low toxicity and is indicated for liver cirrhosis and toxic hepatitis.

Negative opinion: As a hepatoprotector, artichoke leaf extract is widely used, but no evidence-based efficacy studies have been carried out, and it is not recommended for use in acute hepatitis, cholelithiasis and cholestasis syndrome.

bottle 350-400 rubles, 60 tab. 300 rub. 180 tab. 600-700 rub.	Solgar Artichoke leaf extract Price: 60 caps. 1100 rub.
Artichoke Price: 20 tab. about 120 rubles.	Price: 60 tab. 360 rub.

Medicine for the liver - Liv 52, and other dietary supplements

positive opinion- the manufacturer of Liv 52 claims that the extracts of medicinal herbs that make up the drug protect the liver parenchyma in case of toxic damage (drugs, alcohol), normalize the protein-synthetic function of the liver, have a choleretic effect, stimulate the restoration of liver cells, have a slight antioxidant effect, restore the ratio of some phospholipid fractions. It is used for hepatitis, anorexia, for the prevention of liver diseases, cirrhosis. Studies conducted in Russia have shown the effectiveness of using Liv 52 in the treatment of hepatitis A in children, the results were published in an article by experts from the Research Institute of Pediatrics and Pediatric Surgery in Moscow.

negative opinion- however, according to the results of various US studies, the claimed actions of Liv 52 are not noted. For example, in viral hepatitis, taking Liv 52 did not lead to a reduction in the duration of treatment, but there was a decrease in bilirubin in the blood and a reduction in severe weight loss in patients. In the treatment of alcoholic hepatitis, neither antitoxic nor restorative effect was found. Moreover, the results of one of the clinical studies conducted in the United States led to the withdrawal of this drug from the country's market. In the treatment of alcoholic hepatitis while taking Liv 52, the survival rate in the placebo group was 86%, and in the group taking Liv 52 - 74%. In acute liver pathologies, the use of these tablets for the liver aggravated the severity of the inflammatory syndrome.

As for the use of dietary supplements intended for the treatment of liver diseases, its purification, normalization of digestion, this remains the choice of the patient, whether he believes the manufacturer's assurances or not. Since the safety and quality of each series of food supplements can only be confirmed by the manufacturer - a "piece of paper" (certificate of quality), and what will be written there and whether it corresponds to reality is on his conscience. However, there are dietary supplements, the manufacturers of which, taking care of the promotion of the product, confirm their medicinal properties, a positive effect on health by various laboratory and clinical studies, but there are only a few such manufacturers.

Among dietary supplements containing extracts of medicinal herbs, one can distinguish Hepatotransit, Milona 10, Ovesol, Dipana, Hepatrin.

The composition includes aqueous extracts of 10 plants. Price: 48 pcs. 220 rub.

Liv 52 contains extracts of 7 medicinal plants. Price: 100 pcs. 200-250 rub.

as part of silymarin, lecithin, vitamins E, B6, B1, B2, essential phospholipids. Price: 30 pcs.200 rub. 60 pieces350 rub.

contains oat grass, agrimony, voladushki, corn stigmas, powdered lemon juice. Price: 100 rubles.

dandelion roots, burdock, elecampane, artichoke extract, corn silk. Price: 400 rubles.

as a part of Oat Grass, Turmeric, Volodushka Grass and Roots, Sandy Immortelle, Peppermint. Price: 150-200 rubles.

pumpkin seed oil

Positive opinion: The composition of preparations from pumpkin seed oil includes polyunsaturated and unsaturated fatty acids with a high percentage of oleic, linoleic acids - phytosterols, vitamins C and group B, beta-carotene, essential oils, niacin, which has a hepatoprotective effect. A large amount of tocopherols and carotenoids in the composition of the preparations has an antioxidant effect, the presence of essential phospholipids slows down the process of damage to hepatocyte membranes and gives an additional membrane-stabilizing effect, accelerates the recovery of liver cells. Pumpkin seed oil (Tykveol, Peponen) is recommended for use in chronic liver diseases (hepatitis, cirrhosis).

Negative opinion: There is no evidence base for the clinical efficacy of pumpkin seed oil preparations. To judge the real hepatoprotective activity of this agent, additional studies are required.

Tykveol 100 ml 600 rubles, 50 cap. 260 rub.	Peponen	pumpkin seed oil

Homeopathic preparations for the liver

Positive opinion: Among homeopathic preparations, Hepel (Germany) and Galsten (Austria) can be distinguished. It should be remembered that any homeopathic treatment to obtain a tangible effect must be under the control of a homeopath and long enough. Monopreparations with a special affinity for liver cells - May celandine Chelidonium majus and milk thistle Carduus marianus, according to homeopaths, cover most of the symptoms that occur with liver diseases, they are also used as drugs that support the liver.

negative opinion: Homeopathy has both its supporters and its ardent opponents (they consider their effectiveness simply). Homeopathic remedies do not undergo proper clinical research, therefore, there is nothing to say about the effectiveness of these drugs for the treatment of liver diseases.

In custody

Many patients consider herbal preparations and nutritional supplements to be completely safe and sometimes take them without the knowledge of a doctor and without restrictions. This is a big mistake. During treatment, you should tell your doctor about all the dietary supplements, herbs and medications you are taking, as they can be hepatotoxic and interact with other medications you take.

All medicinal plants have a complex composition and contain, although minimal doses, toxic (poisonous) substances. For example, many Chinese herbs have hepatotoxic properties, leading to acute liver failure. Moreover, control over such herbal products (food additives), even in the United States, where the safety of medicines and products is strictly controlled, is not carried out properly. What to say about Russia. Therefore, the use of any herbal remedies should be treated with caution, keeping in mind their possible hepatotoxicity.

So, drugs with proven effectiveness (to varying degrees) are hepatoprotectors:

• Ursodeoxycholic acid
• Amino acid preparations (ornithine aspartate, ademetionine)
• Silymarin preparations are hepatoprotectors with alleged but unproven efficacy, used in certain conditions
• Essential phospholipids - the question of the effectiveness of their use in capsules remains controversial, intravenous administration is more preferable

Cattle liver hydrolysates should not be used due to the potential hazard to the human body. The remaining herbal remedies cannot be recommended for widespread use in chronic liver diseases yet, since their effectiveness has not been adequately proven.

The human liver has an amazing property - the ability to recover on its own. However, in modern conditions of life, it becomes easily vulnerable. The organ is especially vulnerable in those people who do not adhere to the right lifestyle: they consume alcohol, unhealthy food, and various pharmaceuticals. It is not surprising that doctors recommend that many patients take hepatoprotectors - drugs, the list of which is quite extensive. All of them perform the most important function - they contribute to the protection of the liver.

General information

Medicines that have a positive effect on the functioning of the liver and contribute to its recovery are hepatoprotectors.

The drugs, the list of which will be given below, perfectly protect the body from:

• aggressive medications;
• exposure to poisons;
• alcohol.

Their use improves metabolism. They ensure the efficiency of liver cells. Thus, the main function of drugs is to protect the organ from the negative effects of various damaging factors.

Modern pharmacologists have developed a wide variety of hepatoprotectors. The list of drugs is subject to division according to the principle of action and composition. However, all of these medications benefit the liver. But they should be taken only after consulting a specialist.

In addition, it is important to understand that hepatoprotectors are not able to fully protect the body from the harm that alcohol does. The only way to prevent the damaging effect is to keep the body away from alcohol-containing drinks.

Hepatoprotectors (drugs) are prescribed not only for treatment, but also for prophylactic purposes.

The list of medicines included in this group has a fairly wide indications for use:

1. It is advisable to use them for people who constantly interact with chemical, radioactive, toxic components.
2. Such drugs are useful for older people, since their liver often needs medical support.
3. In addition, these funds are beneficial in the fight against diseases of the digestive tract, biliary tract.

But the most important thing is to remember that hepatoprotectors can be used only after a doctor's prescription.

Mechanism of action

The liver is able to function normally only if the cell membranes are intact. If they are clogged, the organ cannot perform the function of cleansing. In this case, hepatoprotectors for the liver are prescribed. The list of effective drugs that can accelerate the process of metabolism in cells is very wide. However, it is not worth using them at your own discretion, without a doctor's appointment.

Hepatoprotectors improve the functioning of the enzyme systems of the body, accelerate the movement of substances, enhance the protection of cells, improve their nutrition, participate in division. All this ensures the restoration of the liver. In addition, the biochemical parameters of the functioning of the organ are significantly improved.

Basic properties

It should be remembered that there are a wide variety of hepatoprotectors. Drugs, the list of which is classified depending on the mechanism of action and the main substance, perform various functions. Some medications restore damaged cells much faster. Others are better at cleansing the liver.

Despite such differences, all drugs have common properties:

1. Hepatoprotectors are based on natural substances, components of the normal natural environment of the body.
2. Their action is aimed at restoring impaired liver function and normalizing metabolism.
3. The drugs neutralize toxic products that enter the body from the outside or are formed inside, due to impaired metabolism or illness.
4. Medicines promote cell regeneration and ensure their resistance to harmful effects.

The use of medicines

So, hepatoprotectors are drugs that have a positive effect on the functioning of the liver. However, they all differ in their mechanism of action. Such agents can provide the following properties to the body: anti-inflammatory, antifibrotic, metabolic.

These drugs are widely used for:

• and non-alcoholic)
• hepatitis (drug, viral, toxic);
• cirrhosis;
• psoriasis;
• cholestatic lesions;
• toxicosis during pregnancy.

Classification of drugs

Unfortunately, until today there is no single system that allows dividing hepatoprotectors (drugs) into groups.

The classification that has found application in medicine is as follows:

1. Essential phospholipids. Medicines included in this group are obtained from soybeans. These are excellent hepatoprotectors of plant origin. List of medicines belonging to this group: Essentiale Forte, Phosphogliv, Rezalyut Pro, Essliver Forte. Plant phospholipids resemble those found in human liver cells. That is why they are naturally embedded in diseased cells and contribute to their recovery. Medicines have virtually no side effects. It is extremely rare that they can cause an allergic reaction if a person has an individual intolerance to the drug, or a loosening of the stool.
2. plant flavonoids. Such medicines are natural compounds - natural antioxidants. The action of drugs is aimed at neutralizing free radicals. Medicines are obtained from medicinal plants: celandine, medicinal fumes, milk thistle, turmeric. These are quite popular hepatoprotectors. List of drugs that make up this group: "Karsil", "Gepabene", "Silimar", "Legalon", "Hepatofalk Plant". Such medicines are characterized by a small list of side effects. In some cases, they can provoke allergic manifestations or loose stools. These drugs have not only a hepatoprotective effect. They perfectly relieve spasm of the gallbladder, improve the outflow of bile and its production. That is why these drugs are prescribed for hepatitis accompanied by cholecystitis.
3. Derivatives of amino acids. These medicines are based on protein components and other essential substances for the body. This ensures the direct participation of these drugs in the metabolism. They supplement and normalize the metabolic process, have a detoxifying effect and support the body. In severe forms of intoxication, liver failure, such hepatoprotectors are prescribed. The list of drugs included in amino acids is as follows: Heptral, Heptor, Hepa-Merz, Gepasol A, Gepasol Neo, Remaxol, Hepasteril. These drugs often provoke side effects. Among them are: discomfort in the abdomen, nausea, diarrhea.
4. Ursodeoxycholic acid medications. These medicines are based on a natural component - Himalayan bear bile. This substance is called ursodeoxycholic acid. The component improves the solubility and removal of bile from the human body. The substance leads to a decrease in damage and death of liver cells in a variety of ailments. Ursodeoxycholic acid has an immunomodulatory effect. With cholelithiasis, fatty hepatosis, biliary cirrhosis, alcoholic disease, it is precisely such hepatoprotectors for the liver that will benefit. List of the most effective drugs: "Ursodex", "Ursodez", "Ursosan", "Ursofalk", "PMS-ursodiol", "Urdox", "Ursofalk", "Urso 100", "Ursodeoxycholic acid", "Ursoliv", " Ursolizin", "Ursor S", "Ursochol", "Choludexan". These medicines are contraindicated in severe liver and kidney failure, pancreatitis, acute ulcers, calcium stones in the gallbladder, acute inflammation of the bladder.

In addition to the drugs listed above, there are other drugs that have hepatoprotective properties.

These include dietary supplements:

• "Gepaphor".
• "Sibektan".
• "LIV-52".
• "Chepagard".
• "Tykveol".

Some homeopathic medicines also have a hepatoprotective effect:

• "Hepel".
• "Galsten".
• "Sirepar".

However, in these medicines, the concentration of the necessary substances is insufficient. Therefore, they are not recommended for use in diseases.

Consider the most effective hepatoprotectors - a list of the best medicines, according to doctors.

The drug "Galstena"

This tool is one of the best medicines for dealing with liver ailments in children. Such a drug can be used from the first days of a baby's life. The medicine is a representative of the group including combined hepatoprotectors (drugs).

The instruction indicates that the drug has a protective effect on liver cells. It promotes the production of bile in a normal consistency. This prevents the formation of stones. The medicine relieves pain in the liver area, relieves spasms.

The drug is used in the treatment of hepatitis. It is also prescribed to prevent damage to liver cells. This remedy is recommended for patients who are undergoing chemotherapy or antibiotic treatment.

The medicine has practically no contraindications. It is not recommended to use it only for those who have an individual sensitivity to the components of the drug.

The drug "Essentiale"

The product is based on highly purified phospholipids. They perfectly normalize metabolic functions in the gland, protect its cells from external influences. In addition, this drug stimulates the recovery of the liver.

The tool is used for the following ailments:

• fatty hepatosis;
• cirrhosis;
• hepatitis.

The drug "Essentiale" in the form of a solution is allowed to be used by children from 3 years of age. The medicine in capsules is recommended for use from 12 years of age.

Means "Antral"

The medicine is used to combat various forms of hepatitis. The drug perfectly allows you to reduce the level of bilirubin, liver enzymes that penetrate into the bloodstream as a result of cell damage. In addition, it is used for prophylaxis in immunodeficiency or chemotherapy.

The tool has an excellent anti-inflammatory effect, promotes the activation of regenerative processes in cells.

The drug has a small number of contraindications and side effects. It is not recommended to use it in acute renal failure.

Medicine is not prescribed for children under 4 years of age.

milk thistle

This is one of the popular herbal hepatoprotectors. The essential substance, silymarin, is obtained from the ripe fruits of milk thistle. It is found in many effective medicines.

Milk thistle-based hepatoprotectors:

• "Legalon".
• "Gepabene".
• Karsil.

Such medicines are used for toxic liver damage, hepatitis, fatty disease. In addition, milk thistle has been scientifically proven to have antioxidant properties. It protects the liver from the development of connective tissue, provides an excellent anti-inflammatory effect.

Such features make it possible to prescribe these hepatoprotectors of origin) to patients suffering from chronic pathologies of the gland.

Medicines based on silymarin are approved for use by children from the age of five.

Medicine "Hepel"

Homeopathic remedy allows you to relieve spasms, restore liver cells, improves the functioning of the gallbladder. The tool is used for various ailments of the gland due to the many therapeutic effects. In addition, this medication is effective for gastrointestinal pathologies, some skin diseases.

The drug can be prescribed even to newborn crumbs (with jaundice). However, only under medical supervision.

The medicine "Holenzim"

The tool is an effective combination drug. It combines bile and certain pancreatic enzymes. This drug enhances the outflow of bile, significantly improves digestion.

The tool is used for cholecystitis, chronic hepatitis and some pathologies of the digestive system. Contraindications to the appointment of the drug "Holenzim" are: acute pancreatitis. In some cases, side effects in the form of allergic manifestations (itching, redness) are possible.

This remedy is contraindicated in children under 12 years of age.

Medicine "Ursosan"

The active ingredient is ursodeoxycholic acid. It provides the formation of liquid compounds with cholesterol. As a result, the body is protected from the formation of stones.

In addition, this substance reduces the production of cholesterol, is an effective protection for liver cells. The tool is used to combat gallstone disease. Effectively eliminates the symptoms of biliary cirrhosis.

The drug is contraindicated in case of obstruction of the biliary tract, the presence of calcified stones.

The medication can only be used for those children who are already 5 years old.

The drug "Heptral"

The tool is based on ademetionine - an amino acid that takes part in many biochemical reactions that occur in the body. This substance improves the physical qualities of bile, reduces toxicity and facilitates its removal.

The medication is prescribed for:

• cholestasis,
• fatty degeneration,
• cirrhotic disorders of the liver,
• chronic hepatitis.

The drug has side effects. It can provoke dyspeptic disorders of the gastrointestinal tract, sleep disorders, mental disorders. Sometimes causes allergic reactions. This tool is not intended for persons under 18 years of age, pregnant and lactating mothers.

The best drugs for children

All of the above allows us to conclude which hepatoprotectors are used for babies.

The list for children contains the following drugs:

1. From the newborn period. Medicines are used: Galstena, Hepel.
2. Toddlers from 3 years old. It is allowed to use the medicine "Essentiale".
3. Children from 4 years old. Assign the remedy "Antral".
4. Five year old children. Therapy may include drugs: Karsil, Legalon, Gepabene, Ursosan.
5. From 12 years old. Prescribe the medicine "Holenzim".
6. Individuals from 18 years of age. You can take the remedy "Heptral".

However, do not forget that any medication should be taken only after being prescribed by a doctor.

The liver is an important gland with many functions. The parenchymal organ synthesizes various substances, participates in the processes of hematopoiesis, stores some vitamins and energy substances, neutralizes and removes toxins. But alcohol abuse, long-term medication, malnutrition, stress and genetic diseases disrupt the functioning of the gland. To restore the functioning of the body, various drugs are used.

The best medicines for the liver are hepatoprotectors. Today, tools such as Liv 52 or Karsil are often used. To determine which is the best of these drugs, you need to familiarize yourself with the features of the medicines.

Hepatoprotector is produced in the form of tablets. The leading components of the drug are plant extracts (chicory, yarrow, nightshade, cassia). Substances protect the membrane of the gland and contribute to its restoration.

This drug is used for violations of liver function:

• Hepatitis
• cirrhosis
• Hepatosis
• Cholecystitis.

Liv 53 tablets are taken orally 30 minutes before meals. For the purpose of prevention, the medicine is drunk twice a day, 2 pills.

In the treatment of children, the dosage does not change. If adult patients are being treated, then take up to 3 tablets three times a day.

After taking a hepatoprotector, the development of adverse reactions in the form of allergies and disruption of the gastrointestinal tract is possible.

Contraindications to taking Liv 52 are blood diseases, hypersensitivity, pregnancy and lactation.

Dragees differ in plant composition. The main component of the hepatoprotector - milk thistle - has an antioxidant, detoxifying and regenerating effect.

It can be used to treat cirrhosis, with toxic lesions and chronic inflammation occurring in the liver.

Instructions for use:

• 1 tablet three times a day.
• The average therapy time is 30 days.

Possible adverse reactions of Karsil are frequent urination, digestive disorders, shortness of breath, allergies, vestibular disorders. Contraindications - age up to 12 years, acute poisoning.

Comparison

It is difficult to make a choice between Karsil and Liv 52. Both drugs are equally effective in protecting the liver from harmful substances.

But hepatoprotectors have some differences. So, the therapeutic effect of Liv 52 may decrease when it is used together with a number of medications. The advantage of Karsil is that the tablets are combined with any medication.

However, Karsil increases the effectiveness of Diazepam. Therefore, before combining drugs, you need to consult with your doctor.

There are many analogues that can replace Liv 52 and Karsil. These are Maksar, Hofitol, Heptral, Legalon, Essentiale, Rezalyut, Gepabene, Ursofalk, Phosphogliv, Ursosan. To understand which of these hepatoprotectors is better, you need to compare them.

To find out which is better in the opinion of doctors Maksar or Heptral, you need to read the reviews of doctors. Opinions of hepatologists vary. The drug Maksar is a strong hepatoprotector, but it is not sold in pharmacy chains. You can order a medicine only on the Internet, which many doctors doubt about the therapeutic effect of the remedy.

When choosing between Heptral or Essentiale, it is worth considering the fact that hepatoprotectors belong to different categories. The first remedy is used to treat severe liver disease. Due to the powerful effect of the drug, it is forbidden to use it under 18 years of age.

Essentiale has a milder effect. The main functions of the tablets are the restoration and maintenance of the gland. Therefore, the remedy can be prescribed from the age of three.

Doctors know that Heptral or Phosphogliv is better. Hepatologists prefer the latter drug, which not only restores hepatocytes, but also relieves inflammation. When choosing between Phosphogliv or Heptral, it is worth considering that the latter has many more contraindications and adverse reactions.

Comparing Gepabene or Essentiale, doctors say that the latter drug is better. Essentiale has a much larger list of indications. In view of this, gastroenterologists consider the drug to be a more effective remedy than Gepabene.

Comparing Heptral or Ursosan, hepatologists pay attention to the fact that the drugs have different active ingredients - S-adenosylmethionine and ursodeoxycholic acid. The first drug is contraindicated in children, and the second can be taken from the age of three.

Phosphogliv or Karsil, which hepatologists know better. Doctors recommend choosing the first medicine. Phosphogliv effectively treats liver diseases, relieves inflammation, restores the organ and prevents the development of diseases in the future.

Rezalut or Heptral are also often compared. Both drugs are quite effective, so the choice should be made by the attending physician, based on the particular patient's body.

Ursosan or Essentiale: which is better to take? Most people with liver disease are convinced that ursodeoxycholic acid is much more effective than herbal ingredients. Therefore, patients prefer Ursosan, the price of which is much lower than on Essential.

Doctors do not know what is better than Legalon and Phosphogliv, since the drugs have almost the same effectiveness. In this regard, doctors often recommend taking these drugs alternately.

Hofitol and Karsil have a vegetable composition. But the artichoke-based drug has much more contraindications. The cost of drugs is approximately the same.

People suffering from cirrhosis or hepatosis, and their attending physicians, do not know what is better than Gepabene or Essentiale Forte. Both hepatoprotectors are effective and safe, which makes them one of the best tools in the fight against liver diseases.

Ursofalk and Heptral: which is better for the treatment of cirrhosis and severe gland pathologies? Reviews say that the first drug is much more effective, but it can only be taken for medical purposes. Heptral is a less effective remedy, and its cost is too high.

If we talk about what is better than Phosphogliv or Liv 52, then doctors pay attention to different groups of drugs. The first remedy is an essential phospholipid, and the second is a plant hepatoprotector. In terms of effectiveness, Phosphogliv is considered stronger, which allows it to be used to treat advanced forms of hepatic diseases. Liv 52 is prescribed for mild disorders in the functioning of the gland. It is also used as a maintenance agent when taking toxic drugs.

Pills for the liver or hepatoprotectors help cleanse the blood of toxins and harmful substances, restore the structures and functions of the body. Medicines have different actions, and their choice should be approached carefully.

The liver performs the function of a filter in the body, and hepatoprotectors help to normalize the functioning of the organ, which is disrupted as a result of prolonged use of alcohol, junk and junk food, fatty foods, and smoking.

Hepatoprotectors are effective for the treatment and prevention of liver diseases, promote the regeneration of hepatocytes, prevent the occurrence of cirrhosis and fibrosis, and slow down the aging process.

Hepatoprotectors are drugs used to treat impaired liver function and various diseases caused by these disorders. Preparations for the liver are also prescribed for hepatitis C, toxic, viral and alcoholic hepatitis, with damage to the organ as a result of drug intoxication, in particular in case of poisoning with anticancer drugs, painkillers and antibiotics.

Modern pharmaceuticals offer different types of drugs for the treatment of the liver, each of the proposed drugs has its own advantages and disadvantages.

Hepatoprotectors help restore such vital functions as:

• hematopoiesis;
• Synthesis of vital elements;
• Neutralization of external and internal toxins;
• Removal of biological substances;
• Formation and removal of bile;
• Urea production;
• exchange processes;
• Destruction of microorganisms that enter the bloodstream through the intestines.

Preparations for the treatment of the liver contribute to the removal of excess substances, purify the blood of toxins and cholesterol, activate the separation of bile, and supply the body with vitamins.

Medicines intended for the treatment and restoration of the liver are effective in relieving pain in the liver area also with:

• Alcohol poisoning;
• Hepatitis;
• cholelithiasis;
• Cholestatic diseases (cirrhosis, cholangitis, cystic fibrosis);
• Dyskinesia of the biliary tract.

Hepatoprotectors react with toxic acids, which provokes the formation of special particles that neutralize the harmful effects of toxins. The active components of these drugs are embedded in liver cells and protect their integrity. The liver has a regenerative property, and taking this group of drugs helps to activate the restoration of damaged cells.

The main functions of hepatoprotectors are the restoration of the outflow of bile, the formation of an appropriate immune response and a decrease in the percentage of harmful cholesterol.

How to choose drugs for the liver

When choosing a drug, it is of great importance to find out the mechanism of action of the drug, which damaging factor should eliminate and treat the drug. Medications are also prescribed taking into account the general health of the patient, the individual tolerance of the components of the drug and the severity of the disease.

It is also important to take into account etiotropic therapy, which is aimed at eliminating the cause of the disease. An example is the treatment of viral hepatitis. Not all viral hepatitis needs to be treated with elimination therapy. With hepatitis caused by virus A, the pathogen dies on its own, and with hepatitis transmitted through blood and sexual contact, antiviral treatment is required.

The choice of the drug should be made by the doctor after finding out the cause of the disease, based on the results of the tests.

When to take hepatoprotectors and what is it

Hepatoprotectors are prescribed for diseases and pathological conditions associated with impaired liver functionality. Often, drugs are included in the course of therapy for:

• Viral hepatitis. Applied when antiviral therapy is not effective or there are reasons why it is impossible to carry out antiviral treatment. Drugs of this group are prescribed for the prevention of cirrhosis. Hepatoprotectors are also used for hepatitis C, regardless of the presence of pain.
• Alcoholic hepatitis. Drugs are used when there are prerequisites for the development of cirrhosis of the liver. Treatment with these drugs will be effective if the patient completely refuses to drink alcohol.
• Fatty liver disease not associated with alcoholism. Obesity can appear in type 2 diabetes. Fat cells begin to form in the liver, which leads to the destruction of its structure. Hepatoprotectors in the presence of such a pathological condition are prescribed as part of complex therapy, subject to diet.
• Drug-induced hepatitis, primary biliary cirrhosis. For the treatment of these ailments, hepatoprotectors are used, a special diet is prescribed.
• The need to eliminate the effects of prolonged use of antibiotics or other drugs that adversely affect liver cells.

Hepatoprotectors act in a targeted manner and provide good results due to high bioavailability, the ability to bind toxins and free radicals, and stimulate the process of self-healing of the organ.

What are hapatoprotectors

Various preparations are offered for the treatment of the liver, which are divided into phospholipids, amino acid derivatives, preparations of animal or vegetable origin, bile acids, homeopathic remedies and dietary supplements.

Hepatoprotectors: a list of drugs

Hepatoprotectors help protect the liver from harmful substances and poisonous elements.

• Herbal preparations include Karsil, Legalon. Medicines are made on the basis of milk thistle fruits. The products contain silymarin, which is the reason for their high efficiency in the treatment of the liver.
• Animal products include Sirepar, Erbisol. Medicines are made from the liver of cattle. The amino acids and cyanocobalamin that make up the drug have a hepatoprotective effect. Erbisol contains low molecular weight organic compounds. Produce a product from the embryonic tissue of animals. The drug activates the regeneration processes of liver cells.
• Essential phospholipids include Essentiale and Lecithin. They help the rapid recovery of hepatocytes due to the fact that the molecules of essential phospholipids are directly integrated into the damaged membranes of liver cells, which allows them to restore their barrier function, and prevents the formation of connective tissue.
• Preparations containing amino acids and their derivatives include Gepatral and Hepa-Merz. This group of drugs helps to reduce the concentration of ammonia in the plasma, increases the protective properties of the liver.
• Antral is a popular and sought-after drug from a number of products with synthetic origin. The drug has a complex effect, has a wide range of applications.
• The list of hepatoprotectors is quite large. Commonly used agents include Silymarin, Darsil, Legalon, Silegon, Karsil, Hepatofalk, Planta, Gepabene, Liv - 52, Silibor, Sirepar, Thiotriazolin, Essentiale Forte, Livolakt, Lecithin, Ornithine oxoglurate, Antral. Gepar compositum, Hepel. This is not a complete list of drugs belonging to the group of heptoprotectors.

Inexpensive and effective

The group of drugs intended for the treatment of the liver is characterized by a mild effect and targeted action. Certain drugs are effective. In most cases, experts stop their choice on drugs:

1. Hepatosan. Available in the form of yellow capsules. It is used for progressive cirrhosis, hepatitis of one of the types, chronic renal failure, intoxication with poisonous and toxic elements.
2. Gepatral. Combined drug with additional antidepressant property. The active ingredient is ademetionine, which activates the process of regeneration of affected organ cells. The drug is prescribed for intrahepatic cholestasis with abnormal restructuring of hepatocytes.
3. Phosphogliv. It is an effective drug, the active ingredients are sodium glycyrrhizinate and phospholipids. The action of the drug is aimed at restoring the affected liver cells, normalizing the functionality of the problem organ.
4. Resolution Pro. The drug replenishes the chemical composition of liver cells, protecting them from the negative effects of pathogenic factors, and slows down the process of cell destruction. An effective remedy for hepatosis, regular drinking in large volumes, hepatitis of one of the types.

Not always the price determines the quality and effectiveness of the drug. Some drugs have an acceptable cost and at the same time have an excellent therapeutic effect.

These funds include:

1. LIV - 52. It is a combined drug with hepatoprotective, choleretic and restorative effects. The price of the drug ranges from 230 to 320 rubles.
2. Allohol. It has a choleretic property, contains natural ingredients, due to which it normalizes the outflow of bile, promotes the breakdown of calculi, after which they are excreted from the body almost imperceptibly. The cost of the drug is about 70 rubles.
3. Hofitol. Contains artichoke extract, which has a beneficial effect on the liver. The drug in most cases is included in the complex therapy. The analogue of the drug is Kafeton. A package (60 pieces) of the drug costs about 360 rubles.

Drugs after drinking alcohol

Recovery of the liver after drinking alcohol is the first thing to organize when identifying problems with the liver, since it is this organ that bears the destructive effects of ethylene. The action of hepatoprotectors is aimed at restoring damaged hepatocytes. Modern pharmaceuticals in its arsenal has various means by which it is possible to prevent serious diseases that develop as a result of regular alcohol consumption.

Recovery drugs

1. Essentiale. The drug contains phospholipids, which have an identical structure with molecules of natural origin. When the liver is damaged, the cell membrane is destroyed, the action of the drug is aimed at preventing the pathological process and maintaining the integrity of the membranes of the liver cells.
2. Essliver. The drug protects the liver, restores damaged organ cell membranes, increases the protective ability of the liver to negative factors and various toxic substances.
3. Phospholigliv. Improves liver regeneration, stabilizes the functionality of the organ in chronic diseases. The drug has a therapeutic effect, eliminates inflammation, prevents the development of atrophy of the liver structures.
4. Enerliv. The drug accelerates the recovery process of hepatocytes, protects the cell membrane from the harmful effects of toxic substances, inhibits the oxidation of lipids in the liver tissues, as well as their transformation.
5. Rezalut. It is a hepatoprotector. Taking the medication allows you to strengthen the liver cells, increase the protective abilities of the organ. The tool actively restores the affected hepatocytes, replenishes the deficiency of phospholipids with identical components.

Medicines to activate regenerative processes

Preparations, the action of which is aimed at stimulating the restoration of damaged liver cells, include amino acids, vitamins, and biologically active components.

1. D I Guard Nano. It is a dietary supplement, accelerates detoxification, promotes the removal of toxic substances from the body, eliminates intoxication. The tool protects the liver from inflammation, prevents the appearance of allergies.
2. Deepana. It is used to treat damaged liver as a result of alcoholism and binges. It contains plant components, the active component is safe for the body, and therefore it is possible to use the drug for a long time. The tool has a fast effect. It can also be used for preventive purposes.

Preparations for strengthening the cell membrane

Cell membranes protect the structure of the liver from damage, and therefore increasing their protective functions is very important for preserving the liver. A popular drug whose action is aimed at protecting the membrane of hepatocytes is Coopers Neo. The drug activates the process of cleansing the liver, the production of bile, normalizes the outflow of bile and the functionality of the bile ducts, ensures the normal viscosity of bile and prevents the formation of microliths. The drug normalizes the process of digestion, reduces the load on the liver.

Cleansing preparations

Medications for cleansing are used after severe intoxication and ethanol poisoning during binge drinking. In such cases, experts recommend taking medications containing knotweed.

1. Karsil. It is a hepatoprotector, contains natural ingredients. The active ingredient is silymarin, which is obtained from milk thistle. The drug acts at the cellular level, has a protective function, prevents damage to the membrane of organ cells.
2. Legalon. The active ingredient of the drug is milk thistle. It has a restorative cleansing effect on the liver.
3. Silimar. Due to the natural composition, the drug has a hepatoprotective and antitoxic effect on the liver. Assign for prophylaxis in liver damage caused by chronic intoxication, alcohol abuse, long-term medication.
4. Gepabene. It contains fumarin, due to which it relieves spasms, accelerates the penetration of bile into the intestines. The silymarin component eliminates the effects of intoxication, promotes the restoration of liver cells. The drug can prevent the manifestation of various liver ailments.
5. Heptral. Normalizes the appearance of bile acids, activates the excretion of bile, stabilizes the motility of the gastrointestinal tract.
6. Hepa-Merz. Helps to reduce the concentration of ammonium in the blood. Applied in violation of metabolic processes of amino acids. It has a protective effect, neutralizes the toxic effects of substances that can damage the liver.
7. Milk thistle extract. The tool helps with a decrease in the protective functions of the liver. The extract contains flavonoids that can act as a protector for the liver, protecting it from the negative effects of toxins. The drug helps to restore the function of the organ and its cells.

For the liver and pancreas

With the manifestation of liver and pancreas disease, complex treatment is required using antispasmodics, enzymes, hepatoprotectors. For the purpose of stopping acute attacks, apply:

1. Festal. Produced in the form of tablets. Applied with an increase in the size of the liver, pancreas. Prescribed for pancreatitis.
2. Lohelan. It is a powder for oral administration. The preparation contains herbal extracts.
3. But shpa. It relieves spasms, anesthetizes, normalizes the functioning of organs. However, the therapeutic effect of the drug is short-lived.

With cirrhosis of the liver and hepatitis

In most cases, these diseases occur in a chronic form and are not completely treated. Often, fatty degeneration of the liver joins the pathologies. The disease is dangerous because it is likely to recur, provoking damage to the parenchyma with a violation of its functionality. Effective for the treatment of these pathologies are:

1. Elsidine. It is a strong hepatoprotector. It has a high cost, restores liver function in case of any violation.
2. Essentiale Forte. Contains phospholipids and natural ingredients. The effect of the drug is gentle, contributes to the normalization of the work of hepatocytes. Progepar is considered an analogue of the drug.
3. Livolin Forte. The drug accelerates lipid metabolism, is effective for the treatment and prevention of fatty hepatosis, fatty liver.

New generation hepatoprotectors

Problems associated with the liver can be solved using modern drugs - new generation hepatoprotectors:

1. Hepatosan. It is a product of animal origin. Contains an enzyme that is obtained from animal liver cells. Effective for non-infectious liver damage.
2. Sirepar. An analogue of an existing drug, the development of the drug was carried out by Russian scientists.
3. Gepa - Merz. Contains natural ingredients. Effective in the presence of foci of liver necrosis. Acts instantly, has a high cost.

From the liver and gallbladder

In the presence of cholelithiasis, not only drugs are prescribed for the treatment of the inflammatory process of the liver, but also medicines that can crush and break down cholesterol calculi. Such drugs speed up the healing process, eliminate pain.

1. Exhol. Produced in the form of tablets. An excellent remedy for the removal of stones from the gallbladder, the normalization of the liver. It is also used for alcohol intoxication.
2. Urosan. It has a choleretic effect, stimulates the splitting of even large stones and removes them with an outflow of bile.
3. Glutargin. Produced in a blister. It has a choleretic and anti-inflammatory effect.
4. Allohol. It has a natural composition, activates the secretory function of liver cells, stimulates the production of bile acids, accelerates the outflow of bile, prevents the spread of infection and reduces inflammation.

With milk thistle

The plant is a source of minerals, vitamins and amino acids. Taking medications containing milk thistle extract helps to overcome liver pathologies caused by toxic substances and infectious agents.

1. Karsil. Contains milk thistle extract. Taking the remedy gives the opportunity to restore liver cells in a short time, strengthen the organ and increase its protective abilities.
2. Gepabene. The drug, despite the low cost, has a strong therapeutic effect. Due to the content of the milk thistle extract, it heals the affected liver cells quickly, does not cause adverse reactions, and has practically no contraindications.
3. Legalon. The drug eliminates toxic attacks on the liver, activates regeneration processes, stimulates the natural reaction of the liver.

dietary supplements

Many hepatologists give preference to herbal preparations for the treatment of liver pathologies, since these drugs have a minimal list of contraindications, after their use there are practically no adverse reactions and negative findings. The choice of a dietary supplement must be agreed with the doctor, since this type of drug should be used taking into account the nature of the disease, the specifics of the body. Popular and effective are:

1. Gepaguard active. The tool acts as a protection of the liver from possible obesity, contributes to the normalization of the state of the organ and its functionality. Eliminates the negative effects of toxic substances, supports the central nervous system, protects cell membranes from oxidation.
2. FanDetox. Contains natural ingredients (persimmon, goji fruit, tangerine peel, buckwheat seed, soy). It has a healing effect, promotes the breakdown of harmful elements, improves metabolism, restores liver function, and lowers cholesterol.
3. Oleoprene Hepa. The action of the components of dietary supplements - a is aimed at stabilizing, improving bioenergetics and the state of hepatocytes. The tool maintains resistance to toxins, intensifies the functions of the hepatobiliary system. It is used in the prevention of ailments and to eliminate the negative effects of pathogenetic therapeutic drugs.
4. Gepalam. It is used for the treatment of diseases of the gastrointestinal tract and liver. The tool is used to reduce the risk of various complications. It is also used to prevent diseases of the liver and bile ducts.
5. Cholesenol. BAA serves as a source of flavonoids and other useful substances. The components of the product increase the resistance of the liver to toxins, restore its structures, basic functions, and protect the cells of the organ. The drug normalizes the process of outflow of bile secretions and enhances gastrointestinal motility. BAA normalizes the functionality of the liver and bile ducts, improves immunity.
6. Milona-10. The product contains natural ingredients derived from medicinal plants. The drug improves the composition of bile, has an antispasmodic effect. Due to the unique composition, radicals are bound, which have a destructive effect on liver cells, and the membranes of hepatocyte cells are stabilized.

Amino acids

These substances activate the liver. They promote the breakdown of fats and remove them from the body. Some amino acids are able to remove ammonia from the body. This group of drugs is also used for failures of brain functions caused by impaired liver function. Amino acids are designed to repair damaged liver cells. The composition of amino acids includes protein, which helps in the process of creating new cell membranes.

Amino acids have many contraindications, drugs in this group are quite expensive. They represent amino acids:

1. Heptral. Available in the form of tablets and drops. In acute forms of diseases, the use of drops is recommended.
2. Gepa - Merz. Released in the form of granules and solution for injection. The drug is allowed to be used only as directed by a specialist.

Homeopathic preparations

Homeopathy has practically no side effects, while at the same time providing a good result. This group of drugs can be used both prophylactically to protect and maintain healthy liver function. This method of treatment is called alternative.

Popular tools in this group include:

1. Edas - 113 Holeton. It is an alcohol-based solution containing extracts of dandelion, celandine. Use by dropping 1 - 5 drops on sugar or dissolving in water, three times a day, before meals.
2. Hepel. Available in the form of lozenges. The composition is multicomponent. Take one tablet on an empty stomach in the morning.
3. Enterix. Produced in the form of capsules for resorption. Contains extracts of chamomile, quinine, echinacea and camphor. Take 6 capsules 4 times a day.
4. Leptandra compositum. multicomponent drug. Produced in the form of a solution. It is intended for the treatment of pathologies of the liver and pancreas. Take 10 drops up to 5 times a day, after meals, dissolved in water.
5. Galsten. The product is available in the form of drops and tablets. Contains extracts of milk thistle, celandine, dandelion and phosphorus. The drug should be taken between meals, 1 tablet or 10 drops. Start taking 4 times a day, then reduce the dose and take it in the morning and at bedtime.

Bile acids

Bile acids contribute to the regeneration of the membranes of liver cells. They are used for cirrhosis, hepatitis of various forms and toxic lesions of the organ. Available only by prescription and most often discharged when the disease is neglected.

Represent this group of drugs:

1. Urosan. Available in capsules. Has no age restrictions for use.
2. Ursoliv. Available in capsules. It is not allowed to use for the treatment of children whose weight is less than 34 kg.

Essential phospholipids

The composition of the preparations of this group includes soybean extract. They contain phosphatidylcholine and unsaturated fatty acids. The preparations, due to their composition, stimulate the natural process of restoring their own walls of liver cells, which are more than half composed of phospholipids.

Phospholipids improve intracellular metabolism, activate the detoxification ability of cells, protect them from the negative effects of toxic substances, neutralize poisons from the intestines, reduce the load on the liver, prevent the formation of connective tissue in the organ, and also increase the effectiveness of interferons. Phospholipids have antioxidant properties. A well-known substance representing the group of phospholipids is lecithin.

Phospholipids are prescribed for fatty tissue degeneration, cirrhosis, and all types of hepatitis.

The most popular drug in this group is Essentiale Forte. It can be produced both in tablets and as a solution for injections and infusions. Phosphogliv and Antraliv are also popular.

Hepatoprotectors in chemotherapy

After chemotherapy, it is important to properly organize drug therapy, which will help restore the structure of the liver. Preparations for the treatment of the liver after radical measures of therapy are prescribed on a purely individual basis, a course of 6 months.

Alpha-lipoic acid is used, which is able to remove almost all toxic substances from the body. Specialists often resort to the use of drugs containing thioctic acid, in particular Thioctacid. The drug is available in ampoules (Thioctacid 600T) and in the form of fast-release tablets Thioctacid BV. Thioctic acid also protects the liver from fatty degeneration in hepatosis.

Prices

Hepatoprotectors can have different costs. Low cost does not indicate the ineffectiveness of the drug. In most cases, medicines for the treatment of the liver, developed on the basis of natural ingredients, have a more acceptable cost. This group of drugs includes dietary supplements - s, homeopathic remedies, herbal medicines.

The drugs of the group of amino acids, fatty acids, as well as drugs designed to restore the liver after radiation or chemotherapy have a high cost.

Basically, prices vary from 150 rubles to 2000 or more, depending on the company that produces the drug and on the composition of the product.

Prevention

For the treatment of liver diseases, it is important to choose a pharmacological group of drugs that meets the requirements of a particular disease. In viral diseases, antiviral agents are chosen, and hepoprotectors are used to prevent and maintain the functionality of the liver.

It is possible to prevent possible complications and the occurrence of side effects when the agent, dose and course are chosen by the attending physician, after clarifying all the nuances of a particular disease, including the individual reaction of the patient's body and the severity of the course of the disease.

It is possible to prevent liver diseases by adjusting the diet, giving up excessive consumption of alcohol and other substances that harm the structure and functioning of the liver.

The use of hepaprotectors - drugs for the restoration and treatment of liver pathologies, as directed, will help prevent the development of dangerous diseases.