Gel for building up the endometrium of the uterus. Ways to build up the mucous layer of the uterus

The endometrium performs a complex function - an egg is embedded in it and divides over several weeks. The inner layer of the uterine cavity plays the role of an early "placenta" for germ cells and provides nutrition, protection, and blood supply. Therefore, before pregnancy, it is necessary to prepare the maturation of a healthy endometrium. If there are problems with the reproductive system, this can be done with the help of hormone therapy, folk remedies. For healthy women, methods such as taking vitamins and including healthy foods in the diet are suitable.

Causes of endometrial growth disorder

The endometrium lines the inner lining of the uterine cavity, which is shed in women during the menstrual cycle. The formation of its cells depends on the effects of hormones produced in the ovaries.

The growth of the uterine epithelium is necessary for the implantation of a fertilized egg. In the first weeks of pregnancy, the endometrium performs a nutritional function, due to which it divides and increases in size.

Estrogen regulates the growth of the endometrium, preparing it for the implantation of an egg. In the female body, this hormone is contained in the follicles that are formed in the ovaries under the influence of the regulation of the central nervous system.

In the second phase of the cycle of a healthy woman, the content of progesterone predominates. It contributes to vascular thrombosis in the thickness of the uterus, resulting in rejection of the endometrium and menstrual bleeding develops.

Growth of the endometrium under the influence of hormones in the menstrual phase

The main causes of dystrophic changes in the epithelial layer of the uterus:

• Curettage during abortion or surgery.
• Hormonal imbalance against the background of inflammatory changes in the genital organs.
• Taking oral contraceptives or using an intrauterine device.
• Hormone-producing tumors that produce large amounts of progesterone.

Treatment

The main goal of therapy is to prepare a woman's body for conception or for IVF (in vitro fertilization). For treatment, medications and folk remedies are used. A beneficial effect is provided by the intake of vitamins and the use of certain foods.

Medicines

The drugs help to quickly build up the endometrium, as they contain a large amount of estrogen. The following medicines are actively used:

• Divigel;
• Utrozhestan;
• Proginova;
• Curantyl.

Divigel

Divigel comes in the form of a gel that is applied to the skin. Contains estradiol, carbomer, ethinol and propylene glycol. The composition includes alcohol, in which the active ingredient dissolves well. This facilitates the penetration of the drug into the blood.

The drug has a powerful estrogenic effect due to the high content of estradiol, a substance that, in chemical and biological properties, resembles a woman's own hormone.

Estradiol penetrates through the cell membrane into the nucleus of the uterine epitheliocyte and binds to specific receptors. After that, a ligand-complex is formed, which enhances the formation of nucleic acids, stimulates the growth of blood vessels and activates the work of the genome.

Actions of the drug:

• Promotes the development of the endometrium (including reduces the activity of the mammary glands, which leads to inhibition of the formation of breast milk and is an additional growth factor).
• Prevents the formation of a deficiency of sex hormones.
• Stimulates and accelerates the healing of connective tissue after surgery or abortion.
• Helps in establishing a regular menstrual cycle.

You can not use the drug in the following conditions:

• allergy to estradiol;
• cancer of the breast and other genital organs;
• uterine bleeding;
• brain tumors.

Divigel is prescribed only by an obstetrician-gynecologist after a thorough examination and study of the content of hormones in the blood.

Side effects:

• headache;
• dizziness;
• chorea (chaotic movements of the arms and legs);
• inflammation of the vein wall;
• increase in pressure;
• vomiting or bloating in case of overdose.

If these symptoms occur, you should consult a doctor.

Utrozhestan

Utrozhestan is available in the form of capsules and tablets that contain the hormone progesterone. This hormone is produced in the second phase of the menstrual cycle and is responsible for the growth, thickening and strengthening of the lining of the inner surface of the uterus. Progesterone promotes conception and pregnancy.

In women with endometrial growth disorder, Utrozhestan is used in combination with estrogenic drugs.

When taking capsules, the hormone is absorbed by the oral mucosa and circulates in the blood for up to 4-6 hours. Excreted in the urine, does not accumulate in the body.

Medication actions:

1. 1. Promotes the correct implantation of the embryo.
2. 2. Helps to get rid of infertility, restores the menstrual cycle.
3. 3. Treats menopausal conditions and luteal insufficiency.
4. 4. With IVF, it helps to prolong the 2nd phase of the cycle, in which there is an increase in the activity of the corpus luteum and growth of the endometrium.
5. 5. Helps cure endocrine infertility (lack of hormones in the ovaries) and endometriosis.

The course of treatment depends on the pathology that caused the pills to be taken. On average, it lasts from 12 to 20 days per month. The dosage is set by the doctor according to the instructions and the initial level of hormones. Overdose or misuse develops urticaria, drowsiness.

Contraindications for the appointment of Utrozhestan:

• thrombophlebitis;
• hereditary porphyria;
• liver and kidney failure;
• ischemic disorders;
• incomplete abortion.

Adverse reactions develop in the form of:

• headache;
• complete absence of menstrual bleeding for 2 cycles;
• bleeding in the middle of the cycle.

Some women develop acne on the face, vomiting, constipation, drowsiness and itchy skin. In this case, it is recommended to cancel the drug.

Utrozhestan should not be used simultaneously with drugs that inhibit liver enzymes. These include rifampicin, spironolactone, barbiturates, and antibiotics. With the joint introduction of these drugs, toxic damage to the liver occurs.

Proginova

Proginova contains a large amount of estradiol valerate, which compensates for the lack of its own estrogen in a woman's body. Valerate is a structural analogue of the hormone, so its main function is to stimulate ovulation.

The drug is absorbed in the oral mucosa, enters the bloodstream and is sent to the liver. Here a transformation reaction takes place, where the active substance is formed from valerate.

Indications for prescribing the remedy:

When planning a pregnancy, Proginova is prescribed to increase the layer of the endometrium.

The medicine should be drunk on the first day of the cycle, the course of treatment depends on the clinical manifestations. Lasts from 15 to 25 days.

• bleeding from the genitals;
• thrombophlebitis;
• hormonal tumors;
• liver pathology.

Contraindications also include breastfeeding and the age of the patient under 18 years of age. Before use, pregnancy should be excluded, since Proginova can lead to miscarriage.

When taking this drug, the following side effects are likely:

• nausea;
• skin itching;
• flatulence;
• allergy;
• swelling;
• increased heart rate.

If any of the above symptoms occur, you must stop taking the medicine.

Curantyl

Curantil is an angioprotective drug. It is used in all areas of medicine; in gynecology, the remedy is prescribed to patients with a complicated pregnancy. As part of complex therapy, the drug is also used to build up a small layer of the endometrium.

The drug contains dipyridamole, it belongs to vasodilators (substances that expand the walls of blood vessels). The drug helps to reduce the formation of blood clots and improves tissue microcirculation. Vasodilation is observed with the introduction of small doses of the drug. Curantyl acts on small-caliber vessels in the uterus.

Curantyl is used in the following cases:

• In order to maintain pregnancy in women with placental insufficiency.
• When planning pregnancy to increase the layer of the endometrium.
• To accelerate the formation of small blood vessels in the thickness of the myometrium and eliminate the phenomenon of fetal hypoxia.
• To eliminate gestosis and eclampsia in women in position.
• In order to prevent the development of malnutrition in newborns.

Curantyl tablets should be taken 2 times a day for a week. In case of emergency pathology of pregnant women, Curantyl is administered intravenously under the control of cardiac performance. Dosage selection is carried out by a doctor. An overdose is accompanied by loss of consciousness, convulsive syndrome, profuse vomiting or an attack of angina pectoris.

• violations of the heart;
• atherosclerosis;
• ischemia;
• diathesis;
• lung pathologies.

Adverse reactions are manifested by tachycardia, skin flushing, lowering blood pressure and dizziness. If the above signs are found, the administration of the drug should be stopped immediately.

Vitamins for the endometrium

They are natural antioxidants and affect many processes in the body:

1. 1. Vitamin E increases the number of small vessels in the inner lining of the uterus, which leads to an increase in the thickness of its layer.
2. 2. Vitamin C can enhance the body's immune defense and promote growth factors in the blood. They are also actively involved in the formation of epithelial cells of the uterine cavity.

These vitamins are part of the following drugs:

• Elevit Pronatal;Preparation method:

  Herbal collection of elder, drop cap, yarrow, chamomile, mint, coltsfoot, nettle is actively used at home. Herbs help to grow the endometrium together with medicines. Also, the collection can prepare for pregnancy a woman who does not have deviations in the menstrual cycle. Plants can improve the quality of the endometrium, which contributes to the birth of a healthy baby.

  Cooking method:

  1. 1. Pour 100 grams of a mixture of herbs with boiling water.
  2. 2. Drink instead of tea 2-3 times a day.

  Healthy foods

  Experts talk about the benefits of pineapple - it contains activators of the hormonal system and a large amount of vitamin C. After eating this fruit, there is an increase in blood vessels in the thickness of the uterus, the maturation of follicles in the ovaries begins.

  Eating pineapples is allowed daily, starting a few days before the expected ovulation.

  Useful foods rich in vitamins C and salicylates are blueberries, raisins, cranberries. Eating 100 grams of these berries daily promotes the growth of the endometrium.

  Every day you should eat 400 grams of fresh vegetables and fruits.

When planning conception, you have to pay attention to many factors necessary for a successful pregnancy. An important place in the structure of pregravid preparation is given to the state of the uterus, in particular, the thickness of the endometrium. And for women who want to have a child, the question becomes relevant, in what ways it can be increased. After all, there is a direct relationship between the size of the endometrial layer and the likelihood of conceiving a child.

General information

The endometrium is the inner layer of the uterus, that is, its mucous (mucosal) membrane. It consists of a prismatic epithelium, represented by secretory, integumentary and basal cells, stromal elements (fibroblasts, histiocytes, lymphocytes) and its own tubular glands. All these components are abundantly supplied with blood by the capillary network of vessels. The latter take an active part in the formation and functioning of the placenta, supplying the fetus with all the necessary components (oxygen, nutrients) and carrying away metabolic products.

The mucous membrane is very sensitive to hormonal effects. Therefore, regular changes occur in the endometrium throughout the entire menstrual cycle. After menstruation, it is restored, undergoing proliferation under the influence of estrogen. And after ovulation, which is accompanied by the release of the egg from the dominant follicle, it undergoes further transformations. Progesterone, synthesized by the corpus luteum of the ovary, stimulates the secretory transformation of the endometrium - the number of glands increases, the mucous membrane swells and becomes looser. This is necessary for high-quality implantation of the embryo and its further development in the uterine cavity.

It is important for women who want to conceive a child to understand how the transition from the phases of the menstrual cycle to pregnancy occurs. Based on the foregoing, the main stages of this process are:

• Maturation of follicles with oocytes in the ovaries.
• Ovulation is the release of an egg from the follicle.
• The meeting of the spermatozoon with the oocyte in the fallopian tube.
• Fertilization of the egg (formation of the fetal egg or zygote).
• Zygote cell division and blastocyst formation.
• Migration of the embryo into the uterine cavity and its attachment to the endometrium (implantation).

From this point on, we can assume that the pregnancy has happened. But the unborn child will have to go through many more stages on the path of development. And the state of the endometrium plays a key role in many processes. For example, the period of placentation is considered critical - the formation of a new organ that supports the life of the fetus. After all, the correct formation of the placenta and the adequacy of its function are largely determined by the morphological maturity of the endometrium.

Mature endometrium is of decisive importance for the onset of pregnancy, ensuring the normal course of critical periods in the life of the fetus.

Physiological indicators

The thickness of the endometrium changes throughout the menstrual cycle. So the uterus reacts to hormonal changes in the body. But many women are concerned about the size of the mucous membrane for conception. First, consider the thickness of the endometrial layer by day of the cycle (table):

Immediately after menstruation, the mucous membrane begins to recover, rapidly growing. The most favorable days for conceiving a child are considered to be a period of 10 to 17 days - the so-called fertile window. During this period, the thickness of the endometrium should average 11–13 mm. This is the generally accepted norm, in which the probability of pregnancy is maximum.

Violations

If the thickness of the endometrium in a woman is insufficient to attach a fetal egg to it, then difficulties may arise with the conception of a child. This naturally leads to infertility. Thinning (hypoplasia) of the mucous layer of the uterus occurs in the following cases:

1. Hormonal disorders.
2. Endocrine diseases.
3. Anomalies in the structure of the uterus.
4. Inflammatory processes (endometritis).
5. Mechanical injury (scraping).
6. Blood supply disorders.
7. hereditary pathology.

But there is also a reverse situation, when the thickness of the endometrium exceeds the norm. Mucosal hyperplasia is also accompanied by infertility, but not only due to local changes in the uterus, but also due to hormonal disorders with the absence of ovulation.

Correction

Many women at the stage of pregnancy planning are wondering how to build up the endometrium for conception. This is especially true for those who have already unsuccessfully tried to conceive a child several times. The thinning of the mucous membrane is quite amenable to therapeutic correction, but before that, the patient will have to undergo an examination to determine the cause of the violations. The list of necessary diagnostic procedures may include:

• A blood test for the hormonal spectrum (gonadotropins, estrogens, progesterone, prolactin) and antibodies to infections.
• A smear from the vagina and cervical canal (cytology).
• Excretion analysis (bakposev, PCR).
• Ultrasound of the uterus and ovaries.
• Hysteroscopy with biopsy.
• Diagnostic curettage.

Based on the results of the examination, the doctor forms a treatment program, taking into account the cause of the changes and the individual characteristics of the patient.

Before carrying out therapeutic correction, the doctor will refer the woman for an examination, the purpose of which is to find out the cause of the thinning of the endometrium and related conditions.

Medicines

You can build up the endometrium with the help of medications. The presence of regulatory disorders in a woman's body is an indication for hormone therapy. Growth and preparation of the uterine mucosa are carried out under the influence of the following drugs:

• Estrogen-containing (Proginova, Divigel).
• Combined estrogen-gestagen (Femoston, Yarina).
• Progestins (Dufaston, Utrozhestan).

Estrogens are prescribed on the 5th day of the cycle, and gestagens are taken after ovulation. Combined agents are used throughout the entire cycle (an appropriate tablet in each phase). This therapy helps the endometrium to fully mature and become ready to receive a fertilized egg.

In addition to hormonal drugs, the doctor may prescribe other medications aimed at eliminating the causes of hypoplasia and normalizing disturbed processes. Based on the situation, antibacterial drugs, non-steroidal anti-inflammatory and even homeopathic drugs are used. The latter, for example, Gormel, activate their own production of hormones and have a mild positive effect on the regulation of menstrual and reproductive functions.

Folk methods

Do not stand aside and methods of alternative medicine. Those who have increased the thickness of the endometrium with folk remedies can probably attest to their effectiveness. But unfortunately, there is no evidence base for such treatment. Of the natural components for building up the mucous membrane, the following can be used:

1. A decoction of the herb of the upland uterus (for ingestion or douching).
2. Sage decoction (taken in the first phase of the cycle).
3. Eating foods rich in vitamins E and C (flax seeds, milk, citrus fruits, black currants).

In the structure of non-traditional treatment, one can find reflex and hirudotherapy (treatment with leeches), as well as physical exercises that stimulate blood flow to the pelvic organs. But in each method, a careful and qualified approach is important. No treatment, including alternative, can be used without first consulting a doctor.

The thickness of the endometrium is an extremely important factor for the onset of pregnancy. If it is insufficient, then the woman will not be able to conceive a child. Therefore, in order to combat infertility, it is necessary to build up the endometrium so that the fetal egg can be qualitatively implanted in the uterus. And the greatest effectiveness should be expected from an integrated approach to treatment.

Often the cause of infertility in women is the underdevelopment of the endometrium. In order for the embryo to be able to gain a foothold in the uterus, its inner shell must have a certain thickness and be sufficiently loose. Abortions, inflammatory processes, infectious diseases lead to the fact that the structure of the inner surface of the uterus is disturbed. A woman who dreams of having a baby has to be treated to build up the endometrium. How to do this, the doctor will tell you after diagnosing and finding out the reasons for the thinning of the uterine mucosa.

Content:

Functions of the endometrium

During each menstrual cycle, the thickness and structure of the lining of the uterine cavity changes. This occurs under the influence of estrogens produced by the ovaries. In phase 1, when an egg matures in them, the thickness of the endometrium increases, and a network of blood vessels grows in it. Progesterone, which is released in the ovaries after ovulation, contributes to the loosening of the mucosa. Conditions are created for the fertilized egg to be able to gain a foothold in the wall of the uterus, and the development of the embryo continues.

What causes endometrial growth? The shell consists of 2 layers: deeper, basal, and superficial, functional. During menstruation, the functional layer peels off and is brought out. At the same time, the mucous membrane becomes thinner to 0.3-0.5 cm. At the end of menstruation, a new functional layer grows from the cells of the basal layer. In a woman of reproductive age, normally, this process is constantly repeated. By the time the egg is fully mature, the endometrium should thicken to 0.9-1.4 cm. This is enough for a woman to become pregnant. The lower acceptable limit is considered to be a thickness of 0.8 cm. If it is less, you need to think about how to build up the endometrium.

Possible complications of underdevelopment of the uterine mucosa

For some reason, a failure occurs, as a result of which the endometrium does not recover after menstruation, it remains too thin. Therefore, a woman is either infertile, or her pregnancy fails. Another consequence of the thinning and violation of the structure of the mucosa is the ectopic fixation of the fetal egg, the occurrence of a pathological pregnancy.

Even if it occurs when the thickness of the endometrium is less than normal, various complications arise. Among them are insufficient supply of nutrients and oxygen to the fetus (this is fraught with a serious violation of its development), improper presentation of the fetus, poor uterine contractility during childbirth.

Causes of underdevelopment of the endometrium

The reason for the insufficient development of the endometrium and its thinning can be:

1. Violation of the hormonal background in the body of a woman as a result of diseases of the pituitary gland, ovaries, thyroid gland, adrenal glands. The use of contraceptives, treatment with hormonal drugs can affect the state of the hormonal background.
2. Curettage of the uterine cavity. During such an operation, there is always a risk of damage to the basal layer, from which a new layer of the mucous membrane grows.
3. The presence of inflammatory processes in the uterus, after which adhesions and scars remain, preventing the restoration of the mucosa.

A common cause of thin endometrium is a violation of blood circulation in the uterus.

Video: Symptoms of a thin endometrium. Causes of pathology, ways to build

Symptoms of pathology, diagnosis

It is possible to assume that the endometrium in a woman is too thin for a number of reasons. Among them, an increase in the duration of cycles, irregular onset of menstruation, hypomenorrhea (scanty menstruation), infertility. There may be severe bleeding after a delay in menstruation (an abortion occurs, which the woman does not know about).

If it is suspected that the cause of infertility is the underdevelopment of the uterine mucosa, a blood test is done for estrogens, progesterone and other hormones. To measure the thickness of the endometrium, an ultrasound of the uterus is performed. Violation of the blood supply is determined using Dopplerography (ultrasound of the blood vessels).

Endometrial Augmentation Methods

There are several ways in which you can build up the endometrium, increase the likelihood of the onset and maintenance of pregnancy.

Traditional treatment is carried out by the following methods:

• drug therapy;
• surgical removal of the defect;
• physiotherapy.

Traditional medicine also offers various proven remedies that help build up the uterine mucosa and save a woman from infertility.

Medical treatment

First of all, the cause of insufficient growth of the endometrium is found out, the underlying disease is eliminated. For example, if the growth of the mucosa does not occur due to the presence of chronic endometritis, then antibiotics are prescribed, as well as drugs to strengthen immunity (cycloferon, geneferon, licopid). Enzyme preparations lidase (promotes the resorption of scars in the uterine cavity) and Wobenzym (anti-inflammatory and immunostimulating effects) are taken.

To eliminate disorders of the menstrual cycle, the homeopathic remedy Gormel drops is actively used. It has an anti-inflammatory, analgesic effect, helps to restore the mucous membranes, stimulating the production of estrogen in the ovaries.

hormone therapy

In the event that the endometrium is too thin due to a lack of female sex hormones in the body, hormone therapy is performed.

In the 1st phase of the cycle, estradiol-based drugs are prescribed with the direct goal of building up the endometrium: divigel, proginova or femoston. Divigel is applied to the skin of the abdomen, quickly absorbed and penetrates into the blood. Proginova is available as a dragee. Femoston is a combined drug, which contains estradiol and progesterone.

In the 2nd phase of the cycle, progesterone preparations (utrogestan or duphaston) are taken so that the growing mucous membrane has a normal structure.

Note: Preparations containing pure estrogens have unpleasant side effects, such as the development of heart disease, vascular thrombosis. The consequence of long-term treatment with estrogens may be the occurrence of malignant tumors. Combined drugs with progesterone are not so dangerous, since this hormone softens the harmful effects of estrogens on the body.

Improving blood flow in the vessels of the uterus

The cause of circulatory disorders in the uterus may be damage to blood vessels during abortions, operations, as well as diseases of this organ. A sedentary lifestyle, taking vasoconstrictor drugs are additional factors for the deterioration of blood flow and nutrition of the cells from which the endometrium is formed.

To improve the blood supply to the uterine mucosa and accelerate its growth, the patient is prescribed drugs such as clexane (prevents the formation of blood clots), chimes (vasodilator), pentoxifylline.

Video: Ways to build up the endometrium

Physiotherapy

Physiotherapy helps improve blood circulation in the uterus, eliminate inflammation of the mucosa.

Procedures such as hirudotherapy (treatment with leeches), acupuncture (impact on receptors that stimulate the sensitivity of uterine membrane cells to estrogen) can help build up the endometrium. Popular methods are also magnetic and electric impulse therapy, electrophoresis, therapeutic exercises, massage.

Surgery

Sometimes adhesions occur in the uterus, preventing the growth of the mucous membrane, the normal course of the menstrual cycle. In this case, only surgical treatment by hysteroscopy helps a woman to eliminate infertility. In this case, adhesions are dissected, scars are removed.

Operations are also performed if the endometrium cannot grow normally due to the presence of tumors in the uterus. In some situations, in order to achieve an increase in normal endometrium, the mucous membrane is scraped along with polyps and cysts that violate its structure.

Folk ways

Some women are afraid of treatment with hormonal drugs. As an alternative, traditional medicine offers recipes that use the medicinal properties of certain plants. You can build up the endometrium using their phytoestrogenic effect and the ability to relieve inflammation, anesthetize, thin the blood.

Sources of phytoestrogens are sage, red clover, hops and many other herbs. Infusions and decoctions are prepared from them. For example, a pinch of dry sage is taken, poured with 1 cup of boiling water and infused for 15 minutes. The decoction is taken after the end of menstruation until about the middle of the cycle. Raspberry leaf tea also has a similar effect.

Effective treatment with infusions of the red brush (drink in 1 half of the cycle) and boron uterus (taken from the middle of the cycle until menstruation). To prepare the infusion of the red brush, pour 1 cup of boiling water 1 tbsp. l. herbs, filter after 4 hours, consume 3 times a day before meals, 1 tablespoon.

The infusion of the boron uterus is prepared with alcohol. Take 1 tbsp. l. dry herbs in 1 glass of alcohol, infused for 2 weeks. The medicine is taken three times a day, 1 teaspoon.

How to accelerate the buildup of the endometrium

In order for the regeneration of the mucosa to occur faster, it is recommended that you eat foods with a high content of vitamin E. This substance stimulates the production of female sex hormones, accelerates tissue repair. Vitamin E is found in spinach, nuts, seeds, carrots, pumpkin, avocados, meat.

It is useful to eat fruits with a high content of vitamin C (pineapples, citruses, black currants). Berries and fruits, as well as honey, contain substances that thin the blood (salicylates). The diet should contain fatty fish - a source of polyunsaturated acids necessary for the formation and nutrition of new cells.

To improve blood circulation in the uterus, you need to move more, go to dances, play sports. Women who are being treated for infertility and dream of getting rid of an endometrial defect are advised to quit smoking.

If a problem such as "thin endometrium" arises, it is advisable to avoid the use of vasoconstrictors (for example, from a cold or allergies).

I don’t want to drink medicines, hormones unequivocally !!! Stimulation is worth it ((((I read that pumpkin juice helped someone, raspberry leaves someone .. Are there any here who, by personal example, had a positive result from traditional medicine treatment .I’m throwing off my span on the endometrium. 7.5 on the transfer. I plan to try again in March-April. I will be glad for advice. Thank you!

On a note!

I was looking on the Internet for what a short and long protocol is, and I found an interesting article, for myself, or maybe you, my dears, will come in handy for someone! Children are the flowers of life, children are our happiness, children are our everything! Unfortunately, the stork does not always bring children, and even cabbage in the garden rarely turns out to be “magic”. It even happens that the whole process of childbearing, or rather childbearing, must be completely and completely entrusted to medicine, because something does not work out in nature. Further, there is a lot of text ...... The process of conception outside the body (in vitro) ...