What birth control pills are recommended for uterine fibroids? Methods of treatment of uterine fibroids without surgery. Removal of fibroids surgically

Myoma is a benign neoplasm, large or small, consisting of elements of muscle tissue. 35% of women under the age of 35 are diagnosed with this disease.

Every third girl under the age of 35 faces fibroid

Types of fibroids

The type of neoplasm is determined from the location of the myomatous nodes. There are types:

Subserous - a neoplasm grows in the abdominal part.
Intramural - fibroids are located within the wall of the uterus. Formation of small sizes.
Submucosal - most of the neoplasm extends beyond the uterus, thereby deforming the cavity. That is a large tumor.

Varieties of fibroids depending on their location

Causes of the disease

The causes of fibroids are a hormonal failure in a woman's body. It is often diagnosed in young women, and sometimes disappears during menopause, as estrogen levels drop sharply.

The main causes of fibroids are distinguished:

Hormonal disbalance.
genetic predisposition.
Inflammatory processes associated with gynecology.
Metabolism failure.
Consequences after abortion.
Diabetes.
Lack of orgasm.
Chronic diseases of internal organs.
Stress. Hormonal disbalance.
Too much estrogen and too little progesterone.

Since the main sign of the occurrence of uterine fibroids is hormonal failure, girls do not have it before the first menstruation. Also in women during menopause. The growth of education occurs with an imbalance in the level of hormones, and its increase. To determine the hormonal background of a woman, it is necessary to conduct repeated tests. Xenoestrogen, which is in the body of a woman, has an estrogen-like effect, which affects the formation of fibroids and endometriosis.

Stress leads to hormonal disruptions and the occurrence of fibroids.

Consequences after abortion

To determine the hormonal background of a woman, you need to find out:

the beginning of the first menstruation;
the number of pregnancies, including premature ones;
lactation period.

In women who have given birth, the risk of tumor formation is minimized.

Food

With impaired metabolism, the level of estrogen increases. Lack of fiber, excess of fatty acids are factors that directly affect the hormone estrogen.

Excess fat mass affects the conversion of androgens into the hormone estrogen. In vegetarians, the development of hormonal diseases is orders of magnitude lower due to the consumption of foods rich in fiber. A diet that does not contain fatty acids reduces the likelihood of disease.

Proper nutrition will help to avoid the accumulation of fats and the occurrence of fibroids.

Lack of satisfaction in sex life

Not getting an orgasm in sex is accompanied by a rush of blood during arousal and its stagnation in the small pelvis. Blood vessels tighten, pain occurs during sex.

If there is no satisfaction in sexual life for a long time, then this leads to hormonal imbalance, which leads to the formation of fibroids.

Diabetes

Impaired metabolism and hypertension increase the possibility of a tumor. The woman's body changes. In urban women, the risk of fibroids is many times greater than in rural women.

Use of contraceptives

Abortions, inflammation, difficult childbirth contribute to a hormonal surge, which leads to a neoplasm.

Treatment

Most women are concerned about the question: "How to treat uterine fibroids?" If a woman has initial signs of menopause and the size of the tumor is less than 12 weeks, that is, small, then conservative treatment of uterine fibroids can be applied. Since growth slows down with the onset of menopause.

Drug treatment is prescribed in the early stages of the disease

Drug treatment of fibroids is carried out with drugs. These include:

COOK. "Mersinol", "Novinet" in their composition: desogestrelone and ethinyl estradiol. "Ovidon" and "Rigevidon" include: norgestrelone and ethinylestradiol. These drugs reduce the signs of a tumor - pain in the lower abdomen and bleeding. Treatment of fibroids to reduce the size, do not use tablets of these groups. The fibroid formation may not decrease. They can be used if the growth of the original size is not more than 1.5 cm, and only then they decrease.

Gonadotropin is a releasing hormone. Drugs of this drug group:
- triptorelin ("Diferelin", "Decapep");
- goserelin (Zoladex);
- leuprorelin ("Lukrin - depot").

The main disadvantage of these drugs:

At the end of myoma therapy, the nodes have the ability to resume to their previous sizes, that is, up to 12 weeks. A long period of taking drugs of this group is unacceptable. This entails the development of osteoporosis and other consequences for the woman's body due to the fact that there is a sharp decrease in estrogen.

"Lukrin Depot" is used to treat fibroids

In the period of six months, when using the drug, there is a reduction in the size of the neoplasm by half. If before the operation it is necessary to reduce the size of the neoplasm, then drug treatment with drugs of this group is used. This reduces blood loss during surgery.

in the treatment of fibroids and initial therapy, antiprogestogens are used. The drugs block the symptoms and affect the reduction in the size of the myoma.

treatment of fibroids with drugs of the antigonatropin group is rarely used. They do not affect the reduction in the size of the nodes. Moreover, these drugs provoke the appearance of:
- excessive hair growth on the body;
- the appearance of acne and pimples;
- voice timbre changes.

These are the effects of drugs.

Such drugs are prescribed if other treatment has been ineffective.

Progestin drugs are unacceptable in the treatment of neoplasms, as some doctors believe. This group includes treatment with duphaston. It is used to treat small neoplasms. Others use the drug to reduce the growth of fibroids. Since the lack of progesterone leads to an increase in the tumor. Take the drug in individual cases and as prescribed by the doctor.

The Mirena spiral is prescribed if the neoplasm is small in size. The drug: "Janine", "Yarina" is prescribed if the formation is small. These are combination tablets. They can be taken for no more than six months.

The drug "Janine" can be used to treat fibroids for 6 months

A method that eliminates fibroid nodes. It is non-recurrent and non-invasive. It is also a non-surgical treatment method. It is based on the evaporation of neoplasms using ultrasonic rays. The rays are directed to the area of localization of education. MRI is used to select the exact direction.

Tomography monitors, in real time, the degree of impact of ultrasound on the myoma.

Advantages

After applying this method, there is no:

blood loss;
do not do anesthesia;
various injuries are not applied;
the reproductive function of a woman is preserved;
the size of myoma nodes is reduced several times;
no side effects;
body temperature does not rise;
the body is not exposed to pain and intoxication;
quick recovery and complete absence of recurrence.

This method allows remote treatment without injuring the uterus.

FUS ablation scheme

When exposed to ultrasonic rays, the following should not appear:

pain in the abdomen and lower back;
pain radiating to the leg;
skin burning.

Non-surgical treatment

If the neoplasm is less than 12 weeks old, then the question arises: “How to treat fibroids?”

For small tumors, less than 12 weeks, conservative treatment is used. First, the endocrine system is checked.

Diagnosis allows you to eliminate the problem in the early stages of the disease.

Tumor treatment without surgery, that is, conservative therapy includes:

dieting;
the use of homeopathic remedies;
phytotherapy;
immunomodulating and hormonal drugs;
physiotherapy.

Directions of conservative therapy:

Prevention of sexual infections.
Strengthening the immune system with herbal medicine and other medicines.
Diet food.
Anemia treatment.
Normalization of menstruation, emotional state and metabolism.

Many women who have been diagnosed with a neoplasm are wondering: “How to treat uterine fibroids?”

After determining the size of the fibroids, the gynecologist prescribes the appropriate treatment

If a fibroid disease is diagnosed when contacting a gynecologist, then the size of the neoplasm is determined. Myoma can be:

6-7 weeks (small sizes);
8 weeks (small sizes);
no more than 12 weeks (also small sizes).

These neoplasms can be treated medically. If the tumor is large, that is, exceeds 12 weeks, then such a disease is treated in gynecology. If the size is small, treatment can be done on an outpatient basis.

That is, large tumors - more than 12 weeks, are treated with medication followed by surgery.

And neoplasms less than 12 weeks - prescribe therapy with hormonal drugs.

Prevention

Of great importance for the prevention of neoplasms is abortion. Multiple interruptions of pregnancy contribute to the formation of a tumor of large or small sizes.

The main method of disease prevention is pregnancy and childbirth. Breastfeeding is also a wonderful prevention of neoplasm. Since the blood contains the hormone prolactin, which stimulates the secretion of milk.

Rational nutrition can also be attributed to the prevention of such a disease.

The use of foods that contain fiber, various vitamins, dairy products contribute to the prevention and prevention of the disease. It all depends on the woman's desire to stay healthy.

Content

Uterine fibroids is a predominantly benign pathology in which a tumor grows in the myometrium. The formation of myomatous nodes is typical for women aged 35-50 years. The age of the patient is of great importance for the appointment of adequate treatment.

Uterine fibroids is a fairly common disease in the field of gynecology. Pathology can develop over the years, eventually leading to dysfunction of internal organs.

Uterine fibroids happen:

multiple and single;
submucous interstitial, subserous, intraligamentary;
on a leg or wide base.

Myoma can be located:

in the neck;
in the isthmus;
in the body of the uterus.

One of the most serious complications of uterine fibroids can be called infertility. Therefore, it is necessary to carry out adequate treatment for uterine fibroids, using drugs prescribed by a doctor in tablets and injections.

Causes and symptoms

The causes of the pathology are not fully understood.

Possible causes of uterine fibroids include:

mechanical trauma to the uterus during surgical interventions;
inflammatory processes in the genital area;
abuse of hormonal drugs;
hypodynamia;
obesity;
endocrine pathologies;
stress;
hormonal imbalance.

Scientists believe that the main cause of the development of uterine fibroids is a hormonal disorder that manifests itself in the excessive production of certain sex hormones, such as prolactin and estrogen. At the same time, progesterone is at a fairly low level.

That is why the basis of the treatment of uterine fibroids is hormonal drugs, for example, Norkolut and Esmya.

Uterine fibroids are usually asymptomatic in the early stages. As the disease progresses, characteristic symptoms may join:

change in the duration of the cycle in the direction of lengthening or shortening;
copious discharge during menstruation;
pain in the lower abdomen during exercise and during intercourse;
growth of abdominal circumference not associated with pregnancy;
violations of defecation and urination;
infertility;
compression of the internal organs by the tumor.

The appearance of pathological symptoms indicates progression of uterine fibroids, which necessitates the use of drugs. The most commonly used injections and tablets.

Treatment

In most cases, the therapy of the disease can be carried out on the basis of drugs. Preparations for the treatment of uterine fibroids help to reduce the manifestations of pathology and stop its development.

If the fibroid is at an early stage and is not accompanied by signs that affect the well-being of a woman, doctors often use expectant tactics. The patient regularly visits the gynecologist and undergoes an examination.

Drug treatment is indicated in the following cases:

relatively small size of nodes;
absence of pronounced symptoms, dysfunction of internal organs and infertility;
contraindications for surgical treatment.

The treatment regimen with medications in tablets and injections is selected by the doctor individually, depending on the following factors:

the age of the patient;
concomitant diseases;
localization and size of nodes;
survey results.

For the treatment of uterine fibroids, the following drug groups of drugs are used:

hormonal;
anti-inflammatory;
immunostimulating and immunomodulating;
homeopathic.

Hormonal medications are essential in the treatment of uterine fibroids.

In modern gynecology, the following medicinal hormonal preparations are used.

Combined oral contraceptives. The drugs in this group are most often based on the combination of Desogestrel and Ethinylestradiol or Norgestrel and Ethinylestradiol. Medicines can eliminate bleeding and pain in the lower abdomen. However, these drugs do not contribute to the reduction of nodes.

Gonadotropin-releasing hormone agonists. Medicines contribute to the onset of artificial menopause, due to the inhibition of the production of certain hormones. When the drug is discontinued, the menstrual cycle is restored. In pathology, drugs are used in the form of injections, sprays and suspensions based on Triptorelin, Goserelin, Nafarelin, Buserelin, Leuprorelin. During treatment, side effects caused by a lack of estrogens can be observed: hot flashes, osteoporosis, depression. Drugs in this group, despite the increased risk of adverse effects, are quite effective. They help reduce fibroids in preparation for surgical treatment.

Antiprogestogens. As part of the use of drugs in this group, mifepristone is widely used, which helps to reduce the tumor and symptoms of fibroids. Tablets are taken by the patient before surgical treatment.
Antigonadotropins. Medicines are used when other means are ineffective. Among the drugs in this group, tablets based on Danazol are used. The drug is used infrequently, as it does not contribute to the reduction of the volume of nodes. In addition, the pills cause a number of undesirable effects associated with an increase in male sex hormones.
Antigestagens. Among the drugs in this group, many doctors recommend the use of Esmya tablets. Drug treatment with Esmya can be attributed to effective hormonal therapy. Esmya contains ulipristal as an active ingredient. This component, which Esmya tablets have, affects the production of certain hormones that cause tumor growth. Esmya also affects the functioning of the pituitary gland. As a result, drug treatment with Esmya has a contraceptive effect in women of reproductive age. During studies, it has been proven that the ability to conceive when using Esmya is extremely low. Tablets contribute to the occurrence of amenorrhea. After stopping drug treatment with Esmya, the normal cycle is restored after about one month.

Esmya tablets act on myoma cells, causing their destruction. Thus, the progression of the growth of uterine fibroids is suspended. Over time, the node decreases. With the help of Esmya, you can also eliminate bleeding in the middle of the cycle associated with the presence of uterine fibroids.

Gestagens. Medications in this group are considered quite effective in the treatment of women of reproductive age. The pills block the production of estrogen.

Among the drugs, the most commonly used drug is Norkolut, which is an analogue of progesterone. Norkolut is a synthetic analogue of the natural hormone progesterone, which acts in the female body in the second phase of the cycle. Norkolut is able to stop tumor growth, reduce blood loss on critical days, and also reduce the thickness of the mucous layer of the uterus. In addition, Norkolut helps to restore the normal cycle and hormone levels. Norkolut can be prescribed for the treatment of intramural and subserous fibroids, endometrial hyperplasia, mastopathy, internal endometriosis and bleeding.

The scheme in the treatment of such a drug as Norkolut, selected for the patient on an individual basis. Of particular importance are the age, type and size of the node, as well as concomitant diseases and reproductive plans.

Norkolut is prescribed in large doses to stop bleeding. Short, long and continuous medication is possible when Norkolut is used on certain days of the cycle. The effectiveness of the treatment with the drug Norkolut is evaluated using ultrasound. Norkolut is not used for submucosal and interstitial tumors, ovarian cyst, torsion of the leg and necrosis of the formation, as well as for suspected malignant process.

With prolonged use of Norkolut tablets, side effects may occur, which are manifested by reactions from the stomach, headaches, edema, enlargement of the mammary glands and body weight.

Norkolut is used quite rarely in women of reproductive age, as it causes anovulation. Young patients are recommended to take Duphaston or Utrozhestan.

Drug treatment usually includes the use of anti-inflammatory drugs in injections, suppositories and tablets. These drugs help to eliminate pain and spasms, reducing inflammation.

Anti-inflammatory treatment with nonsteroidal drugs does not eliminate the cause of the disease, affecting only the painful symptoms.

In the early stages of the disease, some doctors recommend homeopathic medicines that do not have side effects. These preparations contain natural herbal ingredients that have a positive effect on the female body at any age. However, in the later stages of the development of uterine fibroids, such remedies do not have a pronounced result.

In the complex of drug treatment, drugs that have a hemostatic effect are often used. Such drugs are often used in the form of injections for uterine bleeding, which sometimes accompanies the course of uterine fibroids.

Complement the standard treatment with drugs that increase the body's defenses. Such funds are needed with regular blood loss that causes anemia.

Anemia is a dangerous complication requiring appropriate medical treatment. In the absence of adequate therapy, a threat to the life and health of a woman may arise.

As a rule, a woman is prescribed complex vitamins with minerals, or the introduction of immunostimulating and immunomodulating drugs through injections. Most often, the patient is shown injections of vitamins K, E and group B.

Uterine fibroids is a pathology that is subject to mandatory monitoring and drug treatment, mainly with pills, as well as injections. Occurring most often in reproductive age, formations can cause serious complications, the most dangerous of which are torsion of the legs and infertility.

The diagnosis of uterine fibroids does not yet mean unambiguous surgical treatment. If the tumor is small, you can try to treat it with drugs.

In many cases, this gives a positive result, the fibroma regresses. But sometimes, after stopping the medication, it can resume growth.

For the treatment of fibroids, drugs of different groups are used. At the initial stages of the disease, until self-regulation is formed, oral contraceptives can be used. More serious are hormonal agents that cause an artificial menopause - a decrease in the amount of estrogen. Homeopathic remedies and dietary supplements are used as maintenance therapy.

Mercilon

An oral contraceptive consisting of a combination of desogestrel 0.150 mg and ethinylestradiol 0.02 mg. The gestagenic component suppresses the production of gonadotropic hormones, inhibits ovulation. The amount of estrogen is maintained at the same level.

This reduces the proliferation of the endometrium, reduces bleeding during menstruation. For the treatment of fibroids, it is used in the initial stages with a small node size. In this case, he lacks the mechanisms of hormonal self-regulation. A stable hormonal background and gestagens make it possible to contain the progression of the tumor.

Mercilon is taken from the 1st day of menstruation in a chain up to 21 tablets. This is followed by a break for 7 days, during which a menstrual-like discharge appears. Reception of tablets is resumed, even if the allocation of blood has not stopped.

The drug is contraindicated in thrombosis or a tendency to them, liver tumors, in the postoperative period in bedridden patients, during pregnancy.

Novinet

Monophasic oral contraceptive recommended for small fibroids. Consists of ethinylestadiol and desogestrel. Suppresses ovulation by suppressing gonadotropic hormones and prolactin.

At the same time, the growth of myomatous nodes is inhibited. The fact of protection from unwanted pregnancy eliminates one of the risk factors for fibroids - trauma to the muscular layer of the uterus during abortion.

The reception mode includes 21 days from the first day of menstruation, a 7-day pause and the resumption of the cycle.

Contraindicated in the presence of factors that increase the risk of thrombosis:

arterial hypertension;
cardiac ischemia;
thrombosis in history;
violation of the lipid composition of the blood;
liver tumors;
tumors of the reproductive system;
vaginal bleeding of unknown cause;
smoking;
age after 35 years.

Marvelon

Contains 0.03 mg ethinyl estradiol and 0.15 mg desogestrel. The mechanism of action is identical to other oral contraceptives. The package includes 21 tablets, which are taken following the arrow. 7 days after the end of the blister, start the next one. Contraindicated in patients with a tendency to thrombosis, bleeding disorders, pregnancy.

To create a therapeutic effect, the use of Marvelon should be long and continuous. Without harm to health, COCs can be used up to 3 years in a row. They do not lead to regression of the myomatous node, but contribute to its stabilization.

Ovidon

The composition includes levonorgestrel 0.25 mg and ethinolestradiol 0.05 mg. The tablets contain an increased concentration of hormones, therefore they have a more pronounced effect on the hypothalamic-pituitary system. Against the background of the reception, intermenstrual bleeding stops, the pain syndrome during menstruation decreases, they also become less plentiful.

The course of admission is 21 tablets, which are taken in a certain order. During the 7-day break, bleeding occurs, simulating menstruation. After that, the reception is resumed.

Contraindicated in pregnant women and breastfeeding, arterial hypertension, hypercoagulability, dyslipidemia, oncological diseases.

Rigevidon

This is a preparation of ethinyl estradiol 0.03 mg and levonorgestrel 0.15 mg, which are represented by 21 tablets. There is also an additional 7 pills without hormones that contain iron to maintain hemoglobin. The principle of action does not differ from other combined contraceptives.

All 28 tablets in a blister are taken without a break between packs, hormones enter the body for 21 days, and then tablets without hormones are taken for a week. This principle allows you to keep the rhythm and not forget to start the next course. And iron compensates for its loss along with bleeding.

Logest

Monophasic drug, contains ethinylestradiol 0.02 mg, gestodene 0.075 mg. Refers to low-dose hormonal drugs. Protects against pregnancy and inhibits the growth of nodes. There are 21 tablets in one package, which are taken with a seven-day break after it.

Contraindications for admission are bleeding of unknown origin, tumors, jaundice, hemolytic anemia, pregnancy and lactation. Like any oral contraceptive, spotting in the middle of the cycle is possible in the initial three months. If the bleeding increases, you need to see a doctor.

Lindinet

As part of ethinylestradiol and gestodene in a dosage similar to Logest. Contraindicated in pancreatitis, diabetes mellitus, migraine, history of thrombosis, dyslipidemia, acute or chronic liver disease. 21 tablets are prescribed from the first menstruation, after the end there is a pause with spotting, reminiscent of menstruation. A week later, the course is resumed.

Triptorelin

Artificially synthesized analogue of gonadotropin-releasing hormone. It blocks the release of luteinizing and follicle-stimulating hormones from the pituitary gland, which reduces the level of estrogens and androgens. The effect develops by 3-4 weeks of admission.

The condition of the ovaries is approaching the period of menopause. Myomatous nodes, not receiving hormonal stimulation, stop growing and are able to decrease in size. Triptorelin is prescribed to women to prepare for the surgical removal of fibromyomas.

Side effects resemble the course of menopause:

hot flashes;
headache;
emotional instability;
decreased bone mineralization;
myalgia;
constipation or diarrhea;
decreased libido.

After discontinuation of the drug, side effects disappear, fertility is restored. But with the restoration of estrogen levels, the growth of nodes can resume.

It is administered subcutaneously or intramuscularly in depot form.

goserelin

Synthetic analogue of GnRH. Used as a depot hormone. Introduced subcutaneously into the abdomen 3.6 mg once every 28 days. In a different dosage in women is not used. The action is associated with inhibition of the release of LH and FSH, which causes a decrease in the concentration of estrogens.

Fibromyoma regresses, which facilitates the operation. You can't limit yourself to taking hormones. After stopping the course, the tumor resumes growth in most cases.

Side effects are associated with a lack of estrogen, sometimes there is individual intolerance.

Nafarelin

The GnRH analogue stimulates the release of estrogens at the beginning of the intake, and then leads to a decrease, a state of artificial menopause develops, resulting in a decrease in myomatous foci. It is administered intranasally at 200 mg twice a day. Begin to enter from the 2nd to the 4th day of the cycle and continue daily for up to 6 months.

Undesirable effects are similar to the drug in this group. The presence of a runny nose is not an indication for stopping treatment.

Buserelin

Synthetic analogue of GnRH, reversibly blocks the release of LH and FSH. The concentration of estradiol in the blood gradually decreases, decreases to the state of menopause, but after the abolition of the hormonal background is restored. Contraindicated during pregnancy and lactation, with intolerance to the components.

Every 4 weeks, 3.75 mg of Buserelin is injected into the muscle in the form of a prepared suspension. To prepare for the operation, the course is 3 months.

Leuprorelin

Artificially synthesized analogue of GnRH, administered intramuscularly, when taken orally inactive. It causes a state of artificial menopause, which leads to the regression of fibroids. Used to prepare for its removal or as an alternative to surgery. After cancellation, menstrual function will resume within 3 months.

Mifepristone

Synthetic antiprogestogen drug. Connects to progesterone receptors and blocks its action. For the treatment of fibroids, it is used in tablet form of 50 mg. It can only be used for tumors up to 12 weeks of gestation.

Contraindicated in ovarian tumors, endometrial hyperplasia, pregnancy. Side effects - violation of the monthly cycle, amenorrhea.

Danazol

synthetic androgen. Blocks the production of GnRH leads to a decrease in the concentration of LH, FSH. The ovaries are depressed, ovulation does not occur. Reduced estrogen levels - tumor regression occurs.

Possible side effects in the form of emotional lability, sleep disturbances, menstrual disorders, amenorrhea, hot flashes, seborrhea, acne, weight gain. It is used in tablet form.

Gestrinone

It has an androgenic effect, reduces the concentration of progesterone, estrogen in the blood. The effect develops within a month - atrophy of the myometrium develops, bleeding and pain decrease.

Side effects:

seborrhea;
acne
hypertrichosis;
hot flashes;
weight gain;
breast reduction.

Taken in the form of tablets of 2.5 mg on the 1st and 4th days of menstruation. Then they are taken on certain days twice a week for six months.

Norkolut

Norethisterone - the main substance of the drug, has a progestogenic effect, unexpressed androgenic and estrogenic. Reduces the synthesis of gonadotropic hormones, which inhibits the maturation of the follicle and ovulation. For the treatment of fibroids, 5 mg are used from 5 to 15 days of the cycle, the course of therapy is 6 months.

Side effects - engorgement of the mammary glands, swelling, weight gain. Contraindicated in breast cancer, genital organs.

Duphaston

Progesterone preparation, contains 10 mg of dydrogesterone. It is more often used to prevent dysfunctional bleeding that accompanies fibroids. It is prescribed from the 11th to the 25th day of the cycle, 1 tablet 2 times a day.

Dufaston can cause bleeding. To eliminate increase the dose. Side effects - increased sensitivity of the mammary glands, impaired liver function, allergies, peripheral edema. Cannot be used for malignant tumors.

17-OPK

It is an oily solution of a progesterone analogue. It is metabolized more slowly than it, therefore, after injection into the muscle, it has its effect for 7-14 days. The action is identical to progesterone - it transfers the endometrium from the proliferation phase to the secretory one. There is atrophy of the endometrium and a decrease in the volume of the uterus when using a dosage for the treatment of fibroids.

500 mg of the drug is administered twice a week for 3-6 months. Effects develop within 2 weeks.

Mammosan

Homeopathic remedy, has anti-inflammatory, detoxifying effect, regulates hormonal balance. Contains herbal ingredients. Used under the tongue. Lay 5-7 granules before meals 2-3 times a day. The course of admission is long, with breaks for a week after each month.

epigallate

Biological additive, used for diseases of the female genital area. The active ingredient is green tea catechin. In the treatment of fibroids, 2 capsules are used twice a day for at least six months. Used in combination with Indinol.

Contraindicated in pregnancy, lactation, individual intolerance. It is not a drug, but you need to consult a doctor before using it.

Indinol

Possesses antiestrogenic action, reduces proliferation. It is a universal corrector of hyperplastic processes. For the treatment of fibroids, a combination with Epigallat is required - 1 capsule of each remedy twice a day. Contraindicated in pregnancy, lactose deficiency, individual intolerance.

Mirena

The intrauterine device, which releases progesterone continuously. This leads to a decrease in endometrial hyperplasia, slightly inhibits the growth of nodes, and reduces the amount of blood loss during menstruation. Has a contraceptive effect.

The spiral is set from the 1st to the 7th day of menstruation up to 5 years. Then it needs to be replaced.

Contraindicated in pregnant, nulliparous women.

Esmya

Contains a selective progesterone receptor modulator, has an antiprogesterone effect. It has a direct effect on myomatous foci, reducing proliferation and triggering apoptosis. This leads to a decrease in the size of the tumor. Use 1 tablet once a day, a course of 3 months.

Side effects - headache and pelvic pain, hot flashes, swelling, fatigue.

Strategies for dealing with side effects

Side effects when using drugs are inevitable. Some expressed from them can force to cancel drug. To combat the rest, you can use a symptomatic effect.

Psychotherapy sessions, normalization of sleep and rest, diet, interesting leisure activities help.

Examples of treatment regimens

Myoma up to 15 mm- the installation of an intrauterine device or the use of COCs can lead to growth inhibition and even regression of the node.
Fibromyoma in combination with endometrial hyperplastic processes- progesterone preparations (Dufaston).
GnRH agonists are used as monotherapy or in combination therapy with a further transition to surgical removal of nodes.

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Myoma is a benign neoplasm that often forms in women of reproductive age in the uterus. It is completely hormone dependent. This means that any changes in the hormonal background can affect his condition. Including taking hormonal drugs, for example, contraceptives. Contraceptive pills for uterine fibroids are prescribed with some restrictions that are important to consider.

Contraceptives for myoma

Most contraceptives include analogues of the female sex hormones progesterone and estrogen. It is also known that fibroids are hormone-dependent. It grows precisely with an increase in estrogen levels. However, a lot depends on the level of progesterone. If estrogen is elevated relative to progesterone, then fibroids grow.

On the other hand, modern combined contraceptives do not have such an effect. They do not increase the level of estrogen in the blood. On the contrary, their correct (in accordance with the menstrual cycle) intake is able to normalize the hormonal balance. And, in addition, restore the menstrual cycle, disturbed by fibroids. Moreover, some schemes of conservative treatment of such neoplasms involve the use of combined oral contraceptives.

Types of fibroids in the uterus

At the age of 40, they are able to protect against unwanted pregnancy and normalize the cycle. After the age of 40, they are able to facilitate the course of menopause and the period before its onset. In any case, a properly selected contraceptive can positively affect the body with fibroids.

The action of contraceptives

At the age of 40 years, birth control pills for uterine fibroids produce their main effect - protection against unwanted pregnancy. In addition, if they are properly selected, taking them can normalize hormonal balance and stop the growth of fibroids. They also significantly affect the severity of symptoms.

Normalize the menstrual cycle, reduce the intensity of menstruation, bleeding. Sometimes even the pain syndrome becomes less pronounced. It is for this reason that some types of birth control are used as therapy in the treatment of tumors in the uterus.

In women over 40, another positive effect is possible. In addition to preventing unwanted pregnancy and a positive effect on fibroids, the pills have the following effect:

Reducing the risk of cancer;
Increase in bone density due to the normalization of hormonal balance;
Reducing mood swings for the same reason;
Improving the general condition - no fever, sweating;
Increased sexual desire;
Elimination of insomnia;
Reduced anxiety and improved mood.

It is important to remember that you need to select the drug very carefully. It's better if the doctor does it. After the age of 40, drugs that increase estrogen production are not desirable. After all, they can adversely affect the myoma, accelerate its growth.

Contraindications

Despite the fact that oral remedies are considered safe, not everyone can take them. There are the following contraindications:

Progestin contraceptives should not be taken by women over 40 with fibroids, as they increase estrogen levels;
At any age are contraindicated in smoking patients;
Should not be taken with diabetes;
Prohibited for cardiovascular diseases and susceptibility to them (after 40 years);
With frequent tonsillitis and laryngitis, you should not take the drug both before and after 40 years;
Prohibited for obesity;
Do not take with migraines and a tendency to headaches of a different type;
Usually, contraindicated in case of a tendency to depression, mood changes;
Should not be taken with varicose veins, etc.;
With hypertension (especially in women over 40 years old).

The general recommendation is this. Oral contraceptives, especially gestagenic ones, are recommended only for those women who have a regular sexual life. Regardless of age, if this condition is not met, the remedy should not be taken.

List

All oral contraceptives that are currently on the market are divided into two groups - gestagenic and combined. They have various indications and contraindications for admission. They also have their own characteristics of influence on uterine fibroids.

Progestogenic

These are simple one-component preparations. They have the same principle of action and approximately the same composition. Almost never in the presence of fibroids are not prescribed. These include tablets such as:

Microlute;

Ovret;

Continuin;

Charosetta;

Primoliut-Nor;

Lactinet;

Exoluton.

These funds act on the body most gently. However, it is believed that their effectiveness is not high enough, compared with the following types of drugs. They are shown mainly to women under 40 years of age. Can slightly increase the level of estrogen in the blood. Therefore, they are not prescribed in the premenopausal and menopausal period.

Due to a small amount of estrogen, they can adversely affect the fibroid, accelerating its growth. On the other hand, properly selected by a doctor, they may not have a negative impact at all.

Combined

Such drugs are considered the most modern and safe. They are effective, do not have a strong negative impact on myoma. This is due to the fact that they do not significantly change the hormonal level of the patient, do not delay the onset of menopause. Contraceptive pills after 40 years should be prescribed by a doctor. Usually, this is one of the following drugs:

Jess or Jess plus has an antiandrogenic effect, has a positive effect on the gynecological area as a whole and does not cause edema. Shown for use at a younger age;

Depo Provera is the safest. It has a positive effect on the gynecological sphere. One of the newest hormonal agents of this group;

Silest inhibits ovulation and egg maturation by inhibiting the production of hormones by the pituitary gland. Does not have a significant effect on the neoplasm;

Regulon restores the reproductive cycle. Regulon with nodes is prescribed as a treatment, as it can stop its growth and even cause a decrease in the node;

normalizes hormone levels. This helps to stop the growth of fibroids in the uterus;

affects the mucous membrane, delays ovulation. It is also prescribed as a treatment for benign formations in the reproductive system of women. This is due to the fact that the agent can slow down the growth of the tumor or even cause it to shrink;

Femoden normalizes the reproductive cycle. It is indicated for neoplasms, as it reduces the intensity of bleeding and the likelihood of developing persistent anemia;

Triziston does not have a significant effect on education, as it acts differently;

Triquilar normalizes hormonal balance. Suppresses the production of sex hormones and the onset of ovulation. Indirectly affects the nodes in the uterus;

Marvelon shows a complex positive effect. Has high efficiency. Reduces body hair and improves skin. Normalizes hormonal balance, due to which tumor growth slows down.

Despite the fact that combined oral contraceptives are modern and safe drugs, they should be taken in consultation with your doctor. Only he can prescribe the most appropriate remedy in each case.

Admission rules

Contraceptives for uterine fibroids (as well as without it) must be taken according to certain rules. Their observance will increase the effectiveness of drugs. And in the case of fibroids, it will allow the remedy to have the maximum positive effect on the body.

Funds must be prescribed individually by a doctor;

You can take them only if you have a regular sexual life;

Start taking from the first or fifth day of menstruation;

It must be taken at the same time;

The remedy is taken in courses of three weeks, with breaks between them for one week;

If funds are taken for the treatment of fibroids, then the regimen should be developed individually.

You should not hope that taking contraceptives will have a significant positive effect on the neoplasm. This can only happen if initially its dimensions were very small. In other cases, the method is ineffective.
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Article plan

Uterine tumors are a pathology that is diagnosed in 80% of women after 40 years. The main reason for the development of the disease is a disturbed hormonal background, in which an increased concentration of progesterone is observed in the body. A few years ago, medications that reduce estrogen levels were used to combat pathology.

But clinical studies have shown that the level of this substance in the blood does not affect the growth or reduction of neoplasms. Progesterone is responsible for tumor growth. Therefore, in order to normalize its level, hormone therapy is used for uterine myoma.

Indications for admission

In most cases, timely treatment helps to bring hormones in uterine fibroids back to normal without surgery. The main indications for taking medications are:

The tumor is small in diameter (up to 2 centimeters).
Solitary foci (sometimes several adjacent small formations are allowed).
There is no rapid growth of the tumor.
The location of the myomatous formation is the tissues of the uterine wall (intramural form).
Small nodes in the muscular layer of the uterus, located on its outer side and growing towards the pelvic cavity.
No discomfort, no pain.

Hormonal preparations for large uterine fibroids are prescribed in preoperative therapy.

Contraindications to the use of hormone therapy

Not everyone can be treated with hormones for uterine fibroids. There are times when this type of therapy is absolutely impossible to carry out. The main contraindications for admission include:

The presence of a large tumor.
Diagnosis of several nodes located nearby (multiple fibroids throughout the uterine cavity).
The rapid progression of the disease (the neoplasm grows faster than the doctors predicted).
During menopause, hormonal pills for uterine myoma are contraindicated.
If the hormones are incompatible with other drugs taken by the patient on an ongoing basis (drugs that normalize blood pressure or blood sugar levels).

During menopause, hormonal drugs for the treatment of fibroids are prescribed with extreme caution. Indeed, after the complete cessation of periodic secretions in 75% of women, tumors decrease (resolve) on their own.

Hormonal drugs

Today, several groups of medicines are used to treat benign tumors of the female genital organs. Their list is short:

COCs (drugs for the treatment of fibroids of the group of oral contraceptives).
GnRH is an analogue of gonadotropin-releasing hormone.
Drugs that help lower progesterone levels.

There are other groups of herbal medicines that are used to treat benign tumors. The clinical efficacy of these agents has not been proven. But some gynecologists continue to prescribe them for the treatment of uterine nodes.

Combined oral contraceptives

Belonging to this group, are used to treat young women. proved to be effective in the treatment of formations of small sizes (up to 1.5 cm), not accompanied by any symptoms. In most cases, the nodes were diagnosed by chance. Taking contraceptives stops their growth, and also helps to reduce their size.

Hormone Replacement Therapy

HRT (hormone replacement therapy for uterine fibroids) is used to treat women during menopause. Gestagens help reduce the symptoms of menopause. But due to the high content of estrogen, they often provoke the growth of nodes. HRT hormone therapy is associated with risks, so the doctor evaluates the potential risks and the benefit-harm ratio of such treatment for the patient.

Recently, gynecologists prefer to prescribe the most appropriate non-hormonal remedy for women who have entered the menopause period. They contain a small concentration of estrogen. Thanks to non-steroids, it is possible to reduce the manifestation of symptoms of menopause, while simultaneously controlling the size of the tumor.

Gestagens

They contain "pure" progesterone. Previously, they were prescribed for the treatment of fibroids. After all, the cause of the appearance of neoplasms was considered an increased level of estrogen. And funds from the group of gestagens reduce the production of this substance. But since the time when it was found that estrogen does not affect the process of formation and enlargement of nodes, progesterone has ceased to be used in the main therapy for pathology.

Currently, the following drugs are used in the treatment process:

Norkolut. Release form - tablets. They are prescribed for various gynecological diseases.
Promolyut-Nor. It is used in the complex therapy of infertility, PMS, mastopathy, endometrial oncology and other pathologies. This hormonal drug for uterine fibroids has proven its effectiveness.

These pills have many side effects (weight gain, acne, hyperhidrosis). Given the negative manifestations, they are used to treat nodes with extreme caution.

Antiprogestogens

The principle of action of these drugs is the blocking effect of the active hormone on progesterone receptors. Due to this action, the effect of progesterone on the nodes is reduced, and the tumor itself is resolved as a result. Mifepristone is the main active ingredient in antiprogestogens used to treat uterine fibroids. It is present in high concentrations in a number of medicines:

Agesta.
Mifegin.
Genale.

Regardless of the name, the drugs have the same effect on the patient's body. Mifepristone-based medicine can be used for small tumors. In addition, they have a temporary effect.

Antigonadotropins

They are prescribed in rare cases when the use of other drugs has not given the expected result. Antigonadotropins are used to treat uterine fibroids with hormones very rarely - the active ingredients of the tablets reduce the manifestation of the main symptoms of the pathology, but do not affect the size of the nodes.

GnRH agonists

Drugs of this spectrum cause artificial menopause. They inhibit the production of gonadotropin. Against the background of taking drugs of this group, half of the patients experience regression of tumors and a complete cessation of their growth. The disadvantage of this therapy is the exacerbation of all the symptoms of menopause - the absence of menstruation, hot flashes, increased nervousness. To reduce the occurrence of side effects, doctors prescribe GnRH agonists in courses, or in small dosages.

Antiandrogens

They are rarely used in medical practice due to their low efficiency. But in theory, the active ingredients of this group of drugs should block androgen receptors in the affected tissues, reducing hyperplasia and biometric hypertrophy, leaving androgen synthesis stable - at the same level.

Androgens

Medicines reduce the production of hormones in the ovaries, provoking atrophy of the myometrium. They are prescribed for the treatment of menopause (reducing the manifestation of the main symptoms of menopause), bleeding.

Admission rules

What drugs a woman should take and the scheme is determined by the attending physician. But there are a few rules that must be observed while taking medication:

Tablets are taken on an ongoing basis (sometimes in courses with a minimum break of 7 days).
It is necessary to take into account the daily rhythm of hormone production by the body. Tablets are taken during the period of the highest level of their production - in the morning until 11:00.
If oral contraceptives were chosen among all methods of treating tumors, they must be taken in the evening to achieve the maximum therapeutic effect.

Consequences of taking hormones

Most patients are skeptical about hormonal treatment of uterine fibroids. Although reviews of such therapy are positive. Patients believe that the effects of drug use will negatively affect their health. The most common side effects of these medications include:

Pain in the mammary glands with the subsequent development of benign nodes in them.
Increased appetite and body weight.
Swelling of the face, legs (occurs due to fluid retention in the body).
Headaches, general weakness.

To minimize the effects of therapy, doctors prescribe courses or especially small doses. If the therapeutic effect is not achieved, or the risks of deterioration in the patient's health are too high, hormone therapy is stopped.
Hormones after removal of fibroids therapy

After the removal of uterine fibroids, it is important to maintain normal estrogen levels. For this purpose, combined medications are prescribed, which include several biologically active substances. After the operation, women are prescribed a course of tablets with different dosages of active ingredients.

Not all women can take hormones after surgery. Only the attending physician can determine the appropriateness of such post-operative therapy.