Reamberin is a new agent for infusion therapy in the practice of critical care medicine. "Reamberin": indications for use, reviews, instructions, analogues Reamberin tablets instructions for use

Reamberin is a medicine that is sold in the form of a solution for infusion. The action of the drug is aimed at detoxification and providing an antihypoxic effect on the patient's body. Accordingly, it is used for acute intoxications of an exogenous and endogenous nature. Pregnant women and women who are breastfeeding, the drug is contraindicated. It is possible to use it in pediatrics, the drug Reamberin is used in children whose age has reached 1 year.

Dosage form

Reamberin is available in the form of a solution for infusion. Realization is carried out in glass bottles of 100, 200, 400 ml. Bottles are packed in cardboard boxes. Also, the product is available in containers made of multilayer polyolefin film of 250, 500 ml. They are packaged in boxes of 20, 32 pieces for hospitals.

Description and composition

Reamberin solution is a colorless liquid that is transparent.

The active ingredient in the medicinal product is meglumine sodium succinate.

Also in the composition of the drug there are a number of components that perform the function of additional. These include:

• sodium chloride;
• potassium chloride;
• magnesium chloride;
• sodium hydroxide;
• water for injections.

Pharmacological group

The active ingredient of the drug has antioxidant and antihypoxic properties. The substance produces a beneficial effect on cellular anaerobic processes. This happens by reducing the production of free radicals and restoring the energy component of cells.

The drug stimulates enzymatic processes in the citrate cycle. The effect of the substance is noted, which is manifested in facilitating the process of excretion of glucose and fatty acids.

Withdrawals are very fast. There is no cumulation of the substance.

Indications for use

Means of drug action Reamberin is used in patients according to the indications of the attending specialist.

for adults

Indications for the use of Reamberin are acute endogenous and exogenous intoxications.

for kids

Reamberin infusions are used in children older than one year to achieve detoxification and antihypoxic effects in acute exogenous and endogenous intoxications.

Due to the insufficient number of clinical studies on the use of Reamberin in pregnant women, as well as in those who are in the lactation period, the use of droppers for these categories of patients is unacceptable.

Contraindications

There are a number of conditions, the presence of which in a patient obliges the doctor to refrain from prescribing the specified medication to the patient, such for Reamberin include:

• acute renal failure;
• the period of bearing a child;
• recent traumatic brain injury with concomitant cerebral edema;
• kidney disorders of chronic etiology;
• special individual hypersensitivity to any of the components of the drug;
• lactation period.

With renal failure and alkalosis, Reamberin should be used with great caution.

Applications and doses

The introduction of funds is carried out by the drip method. Reamberin is subject to intravenous administration.

The doctor determines the rate of administration of the drug and the required dosage. The treating specialist makes these decisions based on the patient's condition.

for adults

The rate of administration of the substance for adult patients should not be more than 90 drops per minute (1-4.5 ml per minute). The average daily dose is 10 ml per kilogram of body weight.

The use of the drug in elderly patients and patients with renal insufficiency should be carried out with caution. It may be necessary to reduce the rate of administration for the elderly category of patients.

for kids

For children who are 1 year old, Reamberin infusion solution is administered intravenously by drip at a dosage of 6 to 10 ml per kilogram of body weight. The introduction is made once a day. The rate should be 3 to 4 ml per minute. The daily dosage of the drug Reamberin for children is not more than 400 ml.

The duration of the course of drug therapy is no more than 11 days.

for pregnant women and during lactation

The lack of studies proving the safety of using Reamberin in pregnant and lactating women makes it impossible to administer the infusion solution to these categories of patients.

Side effects

Side effects of Reamberin are very unlikely and are extremely low-frequency. Among the actions that may occur against the background of the use of the drug, the following are noted:

• allergic reactions;
• rash;
• dyspnea;
• tachycardia;
• nausea;
• dizziness;
• hyperthermia;
• angioedema;
• dry cough;
• anaphylactic shock;
• pain in the region of the heart;
• excitation;
• headache;
• chills;
• increased blood pressure;
• metallic taste in the mouth;
• sweating;
• convulsions;
• lowering blood pressure;
• pain in the abdominal region;
• diarrhea;
• edema;
• pain at the injection site;
• lethargy;
• tremor;
• hyperemia;
• anxiety;
• phlebitis;
• paresthesia.

If the above reactions occur, the rate of administration of the agent is reduced to the patient.

Interaction with other drugs

In general, the drug Reamberin has a good compatibility.

It can be combined with a glucose solution or water-soluble vitamins or antibiotics.

Mixing the product with other solutions and substances for medicinal purposes is unacceptable.

Also, the use of Reamberin should not be combined with the administration of calcium preparations, since there is a possibility of calcium succinate precipitation.

special instructions

The drug stimulates anaerobic processes, as a result of which the level of glucose in the blood may decrease, and there is also a possibility of an alkaline urine reaction.

Patients suffering from should be treated with caution, in this group it is necessary to control the content of glucose in the blood.

If during storage the color of the product has changed or a precipitate has formed, then the use of this solution seems impossible.

During the period of therapy with Reamberin, driving vehicles or other potentially dangerous mechanisms is not recommended.

Overdose

There is no information on cases of overdose by means. However, there is a possibility of intensification of side effects during long-term treatment of Reamberins at a high dosage.

Storage conditions

Storage of the medicine should be carried out in a dark place inaccessible to children. The storage temperature can vary from 0 to 25 degrees Celsius. It is possible to freeze the Reamberin solution.

The shelf life of the product, in the form of release in glass bottles, is 5 years, and when sold in polymer containers, this period is 3 years from the date of release.

Use after the expiration date is impractical and dangerous.

The release of the drug is carried out with the need to present a prescription from a doctor.

Analogues

There are a number of other dropper solutions that produce a similar effect.

Among the active ingredients of the agent are potassium chloride, magnesium chloride, calcium chloride, sodium chloride, glucose, xylitol and sodium acetate. The drug has a more extensive list of indications for use, Gluxil is used to normalize the acid-base balance in shock conditions, burns and intoxications, long-term purulent lesions, liver disorders, and various infectious lesions.

The active ingredient list of Xylate includes potassium chloride, xylitol, magnesium chloride, calcium chloride, sodium chloride, and sodium acetate. It is used only for therapy in a hospital. Pregnancy and are contraindications to the use of the drug. The Xylat medication, like Reamberin, is used to reduce intoxication, but it also has a list of other indications, such as improving microcirculation, to compensate for the carbohydrate deficiency that occurs in other pathologies of glucose elimination, in traumatic, hemolytic, surgical and burn shock and in some other cases.

Meglumine Calcium Succitate

This tool belongs to the direct analogues of Reamberin. This drug is used for intoxication and has properties similar to Reamberin. Not used during pregnancy and lactation.

Price

The cost of Reamberin averages 650 rubles. Prices range from 131 to 4298 rubles.

REAMBERIN (form - solution) belongs to the group of plasma-substituting and perfusion solutions. The instructions for use highlight the following features:

• Sold by prescription only
• During pregnancy: contraindicated
• When breastfeeding: contraindicated
• In childhood: with caution
• In case of impaired renal function: contraindicated

Package

Compound:

Description:

clear colorless liquid.

Pharmacotherapeutic group:

solutions that affect the water-electrolyte balance.

ATX code:

Pharmacological properties

Pharmacodynamics

Reamberin ® has an antihypoxic and antioxidant effect, having a positive effect on aerobic processes in the cell, reducing the production of free radicals and restoring the energy potential of cells. The drug activates the enzymatic processes of the Krebs cycle and promotes the utilization of fatty acids and glucose by cells, normalizes the acid-base balance and blood gas composition. It has a moderate diuretic effect.

Pharmacokinetics

When administered intravenously, the drug is quickly utilized and does not accumulate in the body.

Indications for use:

Reamberin ® is used in adults and children from 1 year of age as an antihypoxic and detoxifying agent for acute endogenous and exogenous intoxications of various etiologies.

Contraindications:

Individual intolerance, a condition after a traumatic brain injury, accompanied by cerebral edema, acute renal failure, chronic kidney disease (stage 5, glomerular filtration rate less than 15 ml / min), pregnancy, during breastfeeding.

Carefully

With alkalosis, renal failure.

Use during pregnancy and during breastfeeding

It is contraindicated to use the drug Reamberin ® during pregnancy and during breastfeeding due to the lack of clinical studies in these groups of patients.

Dosage and administration

Adults: administered intravenously drip at a rate of 1-4.5 ml / min (up to 90 drops per minute). The average daily dose is 10 ml/kg. The course of therapy is up to 11 days.

Children: administered intravenously drip at the rate of 6-10 ml / kg per day at a rate of 3-4 ml / min. The course of therapy is up to 11 days.

Use in elderly patients

Studies in elderly patients have not been conducted. In this regard, the use of the drug should begin with a slower rate of administration: 30-40 drops (1-2 ml) per minute.

Use in patients with renal insufficiency

Studies in patients with renal insufficiency have not been conducted. In this regard, it is recommended to exercise caution when using the drug in such patients.

Application for alkalosis

If decompensated alkalosis is detected, the use of the drug should be discontinued until the acid-base state of the blood is normalized.

Side effect

With the rapid administration of the drug, undesirable effects are possible, classified according to their frequency of development as follows:

– very often (≥1/10);

– often (from ≥1/100 to<1/10);

- infrequently (from ≥1 / 1000 to<1/100);

- rarely (from ≥1 / 10000 to<1/1000);

- very rarely (<1/10000);

– frequency unknown (frequency cannot be determined from the available data).

General disorders and disorders at the injection site: very rarely - hyperthermia, chills, sweating, weakness, soreness at the injection site, edema, hyperemia, phlebitis.

Immune system disorders: very rarely - allergic reactions, angioedema, anaphylactic shock.

Skin and subcutaneous tissue disorders: very rarely - allergic rash, urticaria, itching.

Respiratory, thoracic and mediastinal disorders: very rarely - shortness of breath, dry cough.

Heart disorders: very rarely - tachycardia, palpitations, shortness of breath, pain in the heart, chest pain.

Vascular disorders: very rarely - arterial hypotension / hypertension, short-term reactions in the form of a burning sensation and redness of the upper body.

Gastrointestinal disorders: very rarely - nausea, vomiting, metallic taste in the mouth, abdominal pain, diarrhea.

Nervous system disorders: very rarely - dizziness, headache, convulsions, tremor, paresthesia, agitation, anxiety.

If any of the undesirable effects indicated in the instructions are aggravated or you notice any other undesirable effects that are not listed in the instructions, tell your doctor about it.

Interaction with other drugs

It goes well with antibiotics, water-soluble vitamins, glucose solution. It is not recommended to mix the drug in a bottle or container with other drugs.

Intravenous administration of Reamberin ® simultaneously with calcium preparations is unacceptable due to possible precipitation of calcium succinate.

special instructions

Due to the activation of aerobic processes in the body by the drug, a decrease in the concentration of glucose in the blood, the appearance of an alkaline urine reaction are possible. In patients with diabetes mellitus or patients with reduced glucose tolerance, periodic monitoring of blood glucose concentration is required.

Influence on the ability to drive vehicles, mechanisms

Release form:

Solution for infusion 1.5%.

100 and 200 ml in glass bottles with a capacity of 125 and 250 ml, respectively, or 400 ml in glass bottles with a capacity of 450 or 500 ml, sealed with rubber stoppers, crimped with aluminum caps or caps combined of aluminum and plastic. Each bottle, along with instructions for medical use, is placed in a cardboard box.

250 or 500 ml in multilayer polyolefin film containers. 32 containers of 250 ml or 20 containers of 500 ml, together with instructions for medical use, are placed in a group container (for hospitals) made of corrugated cardboard. The number of instructions for medical use is equal to the number of primary packages in a group container.

Storage conditions

In a place protected from light at a temperature of 0 to 25 ° C.

Freezing of the drug is allowed.

If the color of the solution changes or the presence of a precipitate, the use of the drug is unacceptable.

Keep out of the reach of children.

Best before date

5 years in glass bottles, 3 years in polymer containers made of multilayer polyolefin film.

Do not use after the expiry date stated on the packaging.

Leave conditions:

On prescription.

Manufacturer:

Scientific and Technological Pharmaceutical Firm POLYSAN LLC

(LLC "NTFF "POLYSAN"). Russia, 192102, St. Petersburg, st. Salova, d. 72, cor. 2, lit. BUT.

Claims of consumers should be directed to the manufacturer.

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Production of Reamberin

Name:

Reamberin

Pharmacological
action:

Reamberin - N-(1deoxy-Dglucitol-1yl)-N-methylammonium sodium succinate solution for intravenous infusion.
N-methylammonium sodium succinate has antihypoxic, detoxifying, antioxidant, cardio-, nephro- and hepatoprotective properties due to the effect on metabolic processes in the body.
Reamberin inhibits lipid peroxidation reactions under conditions of hypoxia and tissue ischemia, stimulates enzymatic antioxidant protection.
Thus, the drug stabilizes the cell membranes of vital organs - the kidneys, liver, brain and heart muscle.
N-methylammonium sodium succinate significantly increases the compensatory capacity of glycolysis along the aerobic pathway due to its activation.

It also has a mild diuretic effect..
It affects the Krebs cycle in mitochondrial cell structures due to inhibition of oxidative reactions and an increase in intracellular energy potential due to the accumulation of creatine phosphate and adenosine triphosphate.
Reamberin does not accumulate in the body after administration, as it is consumed in the metabolic process.
In case of damage to hepatocytes, it stimulates the regenerative capabilities of liver cells, which is clinically evident from a significant decrease in the concentration of markers (enzymes) of hepatic cytolysis syndrome in the blood serum.
After the occurrence of an area of ​​ischemia in the heart muscle (myocardial infarction), N-methylammonium succinate activates reparative processes.

Indications for
application:

Hypoxic conditions of various origins, as well as the need for detoxification (early period after traumatic operations, severe blood loss, anesthesia, acute respiratory failure, acute heart failure, ischemic-hypoxic lesions of vital organs, intoxication of any etiology, including endogenous intoxication, circulatory disorders, xenobiotic poisoning;
- therapy of cholestasis, toxic hepatitis, protracted forms of hepatitis of viral etiology with icteric syndrome (as a component of complex treatment);
- cardiogenic, infectious-toxic, traumatic, hemorrhagic, burn shock.

Mode of application:

Reamberin administered by intravenous drip.
Dosage and rate of intravenous infusion is determined individually, depending on the patient's condition.
For adults the maximum daily dose of the solution is 2 liters.
The usual dosage for adults is 400-800 ml per day.
In severe conditions (shock, intoxication, hypoxia), Reamberin treatment is supplemented with infusion therapy, if necessary, with blood substitutes.
The maximum allowable infusion rate is 90 drops per minute (in terms of the amount of solution - 1-1.5 ml per minute).
In hepatitis of viral etiology, adults are recommended 200-400 ml per day for 2 to 10 days.
At the same time, a study of blood serum is regularly carried out with the determination of enzymes of cytolysis of hepatocytes.
The general course of therapy with Reamberin is from 1 week to 11 days.

In pediatric practice
For newborns and children of 1 year of age, the dose of Reamberin is calculated by body weight - 2-5 ml per kg. The drug is administered 1 time per day.
For premature babies, the drug is administered at a rate of approximately 3-6 ml per hour.
Children 1-14 years old are used at a dose of 10 ml per kg of body weight.
The maximum allowable dose in this case is 400 ml per day.
The recommended rate of administration is 3-4 ml per minute.
The daily dose is divided into 2 injections.
The general course of therapy is no more than 5 days.

Side effects:

Metallic taste in the mouth;
- allergic reactions;
- redness of the upper half of the body and a feeling of heat in case of rapid administration (temporary side effect).

Contraindications:

Condition after a traumatic brain injury, accompanied by swelling of the brain;
- severe violations of kidney function;
- pregnancy;
- lactation period (breastfeeding);
- Hypersensitivity to the components of the drug.
Carefully the drug should be used for alkalosis.
Against the background of the use of Reamberin, an alkaline reaction of blood and urine may occur (due to the activation of aerobic processes in the body).

Interaction
other medicinal
by other means:

The drug can be used in combination with antibiotics, water-soluble vitamins and glucose solution.

Pregnancy:

The drug is contraindicated for use during pregnancy and lactation.

Reamberin is a detoxifying drug that creates an antioxidant and antihypoxic effect. Instructions for use informs that injections in ampoules for injections and infusions in droppers 1.5% help with poisoning and intoxication.

Composition and form of release

Reamberin release form - 1.5% solution for infusion therapy. It is sold in bottles of 200 and 400 ml, polymer containers of 250 and 500 ml.

The active substance of the drug is meglumine sodium succinate, 1 liter contains 15 grams.

As auxiliary components, the composition of the solution includes:

• Sodium chloride - 6 g;
• Potassium chloride - 0.3 g;
• Magnesium chloride - 0.12 g (in terms of dry weight);
• Sodium hydroxide - 1.788 grams;
• Injection water - up to 1 liter.

Reamberin tablets are not produced.

What helps Reamberin?

• skin lesions (psoriasis, various progressive dermatitis, dermatosis) - people with dermatological problems are advised to undergo a two-week course of therapy every 3 to 4 months;
• severe blood loss, acute bleeding due to circulatory disorders in organs and tissues, sepsis;
• heart attack, stroke and other urgent heart conditions;
• violation of gas exchange in the lungs;
• oxygen starvation of brain tissues;
• hepatic dysfunction - icteric syndrome, hepatitis and hepatosis, cirrhosis of the liver, cholestasis, liver failure;
• oncopathology with mestastases, as well as after chemotherapy and radiation therapy.

Indications for the use of droppers

Also, droppers with Reamberin are indicated for severe overdose of alcohol and drugs, a shock reaction against the background of predisposing factors, in preparation for surgery, for emergency therapy after surgical interventions and for patients with severe exhaustion of the body. Moreover, the effect of the drug is noticeable at constant tension and at the stage of adaptation of the body of people professionally involved in sports.

Important! Only a doctor should decide on the need for course pharmacotherapy. Self-medication is absolutely unacceptable.

Instructions for use

Reamberin solution is intended for intravenous administration. Its administration to adults is carried out at a rate of no more than 90 drops per minute (up to 6 ml per minute). The volume of the injected solution depends on the severity of intoxication, it varies from 400 to 800 ml per day.

For children over the age of 1 year, the solution is injected intravenously at the rate of 6-10 ml per 1 kg of body weight of the child 1 time per day, but not more than 400 ml during the day. The rate of administration of the solution is 3-4 ml per minute. The duration of the course of the drug is a period of time up to 11 days.

Pharmacological effects

The active substance protects the heart muscle, nerve cells, liver and kidneys from toxins. It also has antihypoxic, antioxidant and detoxifying activity. By inhibiting the reactions of lipid peroxidation, during hypoxia and tissue ischemia, there is a stimulation of enzymes that exhibit antioxidant activity.

The membranes of the cells of the brain, kidneys, liver and heart are stabilized. Also, the drug has a diuretic effect.

N-methylammonium succinate penetrates into the mitochondria of cells and participates in the Krebs cycle, inhibiting oxidation reactions and increasing the intracellular energy potential (creatine phosphate and adenosine triphosphate accumulate).

Penetrating into the body, the drug does not accumulate, but is completely consumed.

Contraindications

There are a number of conditions, the presence of which in a patient obliges the doctor to refrain from prescribing the specified medication to the patient, such for Reamberin include:

• acute renal failure;
• the period of bearing a child;
• recent traumatic brain injury with concomitant cerebral edema;
• kidney disorders of chronic etiology;
• special individual hypersensitivity to any of the components of the drug;
• lactation period.

With renal failure and alkalosis, Reamberin should be used with great caution.

Side effects

The rapid introduction of the solution can cause the development of the following adverse reactions:

• Cardiovascular system: pain in the heart, shortness of breath, palpitations, tachycardia, chest pain;
• Immune system: anaphylactic shock, angioedema, allergic reactions;
• Skin and subcutaneous tissue: itching, urticaria, allergic rash;
• Vascular disorders: sensation of heat and redness of the upper body (of a short-term nature);
• Gastrointestinal tract: metallic taste in the mouth, vomiting, abdominal pain, nausea, diarrhea;
• Respiratory disorders: dry cough, shortness of breath;
• Nervous system: anxiety, headache, agitation, dizziness, paresthesia, tremor, convulsions;
• Changes at the injection site and general disorders: weakness, sweating, soreness at the injection site, chills, hyperthermia, edema, phlebitis, hyperemia.

Reamberin analogs

Analogues are prescribed for treatment:

1. Meglumine sodium succinate;
2. Anexat;
3. Antakson;
4. Artamine;
5. Acizol;
6. Bianodyne;
7. Bridan;
8. HepaMerz;
9. Gluconeodes;
10. Glutamic acid;
11. Dalisol;
12. Desferal;
13. Dianil;
14. Digitalis antidote BM;
15. Zorex;
16. Ionostigmine;
17. Calcium folinate Ebewe;
18. calcium folinate;
19. Carbactin;
20. Carboxyme;
21. Carbopect;
22. Karbosorb;
23. Cardioxan;
24. Kuprenil;
25. Lamisplat;
26. Larnamin;
27. Levulose;
28. Leucovorin calcium;
29. Lignin;
30. Medetopect;
31. Naloxone;
32. Naltrexone;
33. Ornilatex;
34. Ornitsetil;
35. Pelixim;
36. Pentacin;
37. Polifan;
38. Polyphepan;
39. Sanitized;
40. Sorbex;
41. Trekrezan;
42. Unithiol;
43. Uromitexan;
44. Filtrum Ste;
45. ceruloplasmin;
46. Extraneal;
47. Enterodes;
48. Epilapton;
49. Etiol.

drug interaction

If necessary, to further support the patient's body or if there are special indications for treatment, the specialist may recommend the introduction of Reamberin along with glucose, liquid vitamins of different groups, antibiotics.

It is strictly forbidden to mix medicines in a bottle with a liquid solution for injection or a container with other medicines. The instruction recommends refraining from the simultaneous use of Reamberin with potassium-containing drugs due to the possible formation of a precipitate of calcium succinate.

Special conditions

During the period of treatment with the drug, the likelihood of an alkaline reaction of urine and blood is not excluded (the reason for such changes is the activation of aerobic processes in the body).

If the color of the solution has changed, or foreign impurities have appeared in it, it cannot be used.

Price and holiday conditions

The average price of Reamberin, solution (Moscow), is 149 rubles. Released by prescription.

Store in a place protected from light, out of the reach of children, in compliance with the temperature regime of 0-25 ° C. Freezing the solution is allowed. Shelf life - 5 years.

Intoxication of the body with harmful substances accompanies us everywhere. This is malnutrition, and ecology, and viral, infectious, autoimmune diseases. It is very important to conduct a timely detoxification of the body. Otherwise, complications may develop, up to death.

One of the effective drugs for detoxification is Reamberin. Instructions for use of the drug indicates that it is used to treat the liver, kidneys, heart, and infectious pathologies. It is important to note that Reamberin is produced exclusively in the form of a solution for intravenous administration. Therefore, therapy is carried out within the walls of the clinic.

The tool is available in the form:

• solution for infusions 1.5%; bottle (bottle) glass 400 ml box (box);
• solution for infusions 1.5%; bottle (bottle) glass 200 ml box (box);
• solution for infusions 1.5%; polymer container 250 ml;
• solution for infusions 1.5%; polymer container 500 ml;
• solution for infusions 1.5%; bottle (bottle) glass 100 ml box (box).

The composition of the drug includes:

Among the auxiliary agents, sodium hydroxide is noted - 1.788 g, water for injection - up to 1 liter.

pharmachologic effect

A drug with a detoxifying effect for parenteral use. It has antihypoxic and antioxidant effects, having a positive effect on aerobic processes in the cell, reducing the production of free radicals and restoring the energy potential of cells.

The drug activates the enzymatic processes of the Krebs cycle and promotes the utilization of fatty acids and glucose by cells, normalizes the acid-base balance and blood gas composition. It has a moderate diuretic effect.

Worth knowing! The only possible way to use the drug Reamberin is a dropper.

This pharmacological agent belongs to complex drugs with a large number of medicinal properties:

• detoxification effect;
• antihypoxic action;
• antioxidant action;
• nephro-, cardio- and hepatoprotective effect;
• inhibition of lipid peroxidation under conditions of hypoxia or tissue ischemia;
• stimulation of antioxidant enzyme protection;
• stabilization of the membranes of the cells of the brain, liver, kidneys, heart;
• increasing the compensatory capacity of glycolysis;
• stimulation of regeneration of liver cells;
• activation of reparative processes in myocardial infarction;
• diuretic effect.

All these functions make the scope of the drug very wide, it includes various types of intoxication of the body, diseases of the liver, kidneys, heart, internal infections.

Indications for use

Reamberin is used in adults and children from 1 year old as an antihypoxic and detoxifying agent for acute endogenous and exogenous intoxications of various etiologies.

The drug is prescribed if detoxification is necessary:

• early period after traumatic operations;
• severe blood loss;
• anesthesia;
• acute respiratory failure;
• acute heart failure;
• ischemic-hypoxic lesions of vital organs;
• intoxication of any etiology, including endogenous intoxication;
• circulatory disorders;
• xenobiotic poisoning.

The drug is effective as a therapy for cholestasis, toxic hepatitis, protracted forms of hepatitis of viral etiology with icteric syndrome (as a component of complex treatment). In general, Reamberin is used to treat any liver disease, including psoriasis, helminthiasis.

Contraindications

The drug is contraindicated for use in the following cases:

• condition after a traumatic brain injury, accompanied by cerebral edema;
• severe renal dysfunction;
• pregnancy;
• lactation;
• hypersensitivity to the components of the drug.

Applications and doses

The rate of administration of the drug and the dose are determined in accordance with the patient's condition. The duration of the course of administration of the drug depends on the severity of the patient's condition, but not more than 11 days.

Worth knowing! Reamberin is administered intravenously at a rate of no more than 90 drops / min.

For adults

For adults, the maximum daily dose of the solution is 2 liters. The usual dosage for adults is 400-800 ml per day.

In severe conditions (shock, intoxication, hypoxia), treatment is supplemented with infusion therapy, if necessary, with blood substitutes.

In hepatitis of viral etiology, adults are recommended 200-400 ml per day for 2 to 10 days. At the same time, a study of blood serum is regularly carried out with the determination of enzymes of cytolysis of hepatocytes.

With psoriasis, Reamberin is used for a long time - for 10-14 days it is necessary to use 400 ml of the drug. It is recommended to take several such courses per year with a break of 3-4 months between them.

For kids

For children older than 1 year, the drug is administered at the rate of 10 ml / kg of body weight once a day at a rate of not more than 60 drops per minute (3 ml / min).

For pregnant women and during lactation

The drug is contraindicated for use during pregnancy and lactation.

Side effects and overdose

Among the adverse reactions are the following:

• metallic taste in the mouth;
• allergic reactions (itching, burning, urticaria);
• redness of the upper half of the body and a feeling of heat in case of rapid administration (temporary side effect);
• shortness of breath, tachycardia, cough;
• a sharp decrease or increase in blood pressure;
• dizziness, nausea, vomiting;
• convulsions, swelling;
• anaphylactic shock.

With excessive use of the drug, negative phenomena may appear, expressed in the form of a sharp decrease in blood pressure. In order to eliminate the consequences, you need to stop taking the drug and conduct proper treatment.

special instructions

Due to the activation of aerobic processes in the body by the drug, alkalization of blood and urine is possible. If the color of the solution changes or the presence of a precipitate, the use of the drug is unacceptable.

Interaction with other drugs

It goes well with antibiotics, water-soluble vitamins, glucose solution.

Storage conditions

The drug should be stored out of the reach of children, protected from light at a temperature of 0° to 25°C. Freezing of the drug is allowed. Shelf life - 3 years.

Important! If the color of the solution changes or the presence of a precipitate, the use of the drug is unacceptable.

Analogues and price

There are a number of other dropper solutions that produce a similar effect:

1. Gluxil
   Among active ingredients means potassium chloride, magnesium chloride, calcium chloride, sodium chloride, glucose, xylitol and sodium acetate. The drug has a more extensive list of indications for use, Gluxil is used to normalize the acid-base balance in shock conditions, burns and intoxications, long-term purulent lesions, psoriasis, liver disorders, and various infectious lesions.
2. Xylat
   List The active substances of Xylate include potassium chloride, xylitol, magnesium chloride, calcium chloride, sodium chloride and sodium acetate. It is used only for therapy in a hospital. Pregnancy and lactation are contraindications to the use of the drug. The Xylat medication, like Reamberin, is used to reduce intoxication, but it also has a list of other indications, such as improving microcirculation, to compensate for the carbohydrate deficiency that occurs in diabetes mellitus and other pathologies of glucose elimination, in traumatic, hemolytic, surgical and burn shock and in some other cases.
3. Meglumine Calcium Succitate
   This tool belongs to the direct analogues of Reamberin. This drug is used for intoxication and has properties similar to Reamberin. Not used during pregnancy and lactation.

The cost of Reamberin averages 650 rubles. Prices range from 131 to 4298 rubles.