What helps Indapamide? Instructions for use. Contraindications to the use and side effects of the drug indapamide

Indapamide is a diuretic used in primary and secondary hypertension. The drug begins to act 30 minutes after ingestion (bioavailability ~ 93%), the therapeutic effect is observed within a day.

The maximum concentration of the active substance indapamide in the blood is after 12 hours. The elimination half-life is approximately 18 hours (14 to 24 hours). The equilibrium concentration is established after 7 days of regular intake.

In therapeutic doses, tablets have practically no effect on lipid (triglycerides, high and low density lipoproteins) and carbohydrate metabolism. In patients with renal insufficiency, the pharmacokinetic parameters of elimination do not change.

Indications for use Indapamide

Indapamide 1.5 mg photo

Indications for the use of indapamide due to pharmacological action - it is diuretic, hypotensive. The hypotensive effect is manifested only with initially elevated blood pressure, develops by the end of the first week and persists for 24 hours against the background of a single dose of indapamide.

The maximum result is noticeable after 3 months of systematic use.

What helps indapamide?

Arterial hypertension;
Sodium and water retention in chronic heart failure.
Effective use of Indapamide as a diuretic in edematous syndrome on the background of chronic heart failure.

Indapamide - instructions for use

Indapamide tablets are taken orally, preferably in the morning. Drink plenty of fluids (water).

With arterial hypertension, 1 tablet is shown once a day, depending on the form of release of the drug:

Indapamide - 1.25-2.5 mg 1 time per day
Indapamide retard - 1.5 mg once a day

With insufficient effectiveness of indapamide after 4-8 weeks, it is advisable to add drugs with a different mechanism of action to therapy. An increase in the dosage of Indapamide does not increase the hypotensive effect, but significantly increases the risks of complications and the diuretic effect.

Indapamide for pressure- as indicated above, 2.5 is the maximum recommended dosage of the drug per day. The therapeutic effect is cumulative, and is achieved over time, and not by increasing the dose. This also applies to the use of indapamide tablets for pressure and edematous syndrome against the background of CHF.

It is recommended to use 1 tablet of indapamide 1.5 mg retard 1 time / day.

Contraindications

According to the instructions for use of indapamide, the drug is contraindicated in case of hypersensitivity to the active substance (Indapamide), other sulfonamides or auxiliary components of the drug.

Diseases - severe renal failure, hepatic encephalopathy and severe liver dysfunction, hypokalemia.
Since indapamide is a diuretic, it should be taken with caution in case of kidney pathologies, an additional consultation with a doctor is required.
The use of Indapamide is contraindicated in patients under the age of 18, as well as while taking drugs, the action of which is aimed at lengthening the intervals of the electrical systole of the heart.
Self-administration of indapamide during pregnancy and lactation is contraindicated. Acute or recent cerebrovascular accident.

Special instructions:

In patients taking cardiac glycosides, laxatives, on the background of hyperaldosteronism, as well as in the elderly, careful monitoring of the content of K + and creatinine is shown. The first measurement of potassium concentration in the blood should be carried out within 1 week of treatment.

Increases the concentration of Li + in plasma (decreased excretion in the urine), lithium has a nephrotoxic effect.

Indapamide tablets should be administered with caution to people suffering from diabetes mellitus. In this case, glucose levels should be monitored.

While taking the medication, there may be an exacerbation of the symptoms of SLE ().

When the drug is used by athletes, the action of indapamide can be the cause of a false positive reaction during a doping test.

All contraindications and precautions apply to the drug indapamide 1.5 retard.

Indapamide analogues (list)

Indapamide tablets have structural analogues for the active substance. These are drugs for the treatment of persistent high blood pressure:

Acrypamide
Acripamide retard,
Arindap, Arifon,
Arifon-retard (French analogue),
Vero-Indapamide,
Indapamide MV-Stada (Russian analogue),
Indapamide-retard (Russian analogue),
Indapamid-Stada,
Indapres,
Indapsan,
indipam,
ionic,
ionic retard,
Ypres-long,
Lorvas SR,
Ravel SR,
Retapress,
SR-Indamed.

Please note that the instructions for the use of indapamide, the price and reviews of analogues do not apply, be sure to consult your doctor before using it about the possibility of a replacement. This is primarily due to a possibly different dosage of the active substance in tablets of indapamide analogues.

High blood pressure provokes the occurrence of many pathologies and can cause a stroke or heart attack. To effectively reduce pressure indicators, doctors often prescribe the drug Indapamide. Complete information about the drug Indapamide and why it is prescribed, will tell the attending physician.

Description of the drug Indapamide

Indapamide is a diuretic that is prescribed to successfully reduce pressure. It is produced in the form of tablets and a substance - a powder. The main active substance is indapamide. Also, the composition includes additional substances that perform various auxiliary functions.

The mechanism of action on the body

Indapamide is prescribed for conditions requiring hypotensive, diuretic and vasodilating effects. The mechanism of action of Indapamide is based on a decrease in the strength of contractions of peripheral vessels. Sodium is excreted in the urine, due to this, the functioning of calcium channels is enhanced, the walls of the arteries become elastic. A medication is prescribed for hypertension, to get rid of edema in chronic heart failure.

Indapamide is prescribed to actively lower blood pressure. After taking it, the therapeutic effect lasts up to 24 hours. Already a week after the start of the reception, stabilization of the condition of the sick person is felt. The maximum result from Indapamide is achieved one month after the start of treatment.

Indications for the appointment of Indapamide

The drug is prescribed for two indications - arterial hypertension, reduced swelling in heart failure. The drug is well tolerated, so Indapamide is also prescribed for patients with diabetes mellitus, hyperlipidemia (high cholesterol) and chronic renal failure. Since the medication has shown good results, it is also prescribed to patients undergoing hemodialysis or having one kidney.

For high blood pressure, the best way is to take a diuretic such as Indapamide. The agent acts on the body gently, with a cumulative effect, without damaging the blood vessels. Indapamide is prescribed as an independent drug or in complex treatment as an additional agent.

Side effects

The drug Indapamide is prescribed only by doctors. Indapamide can cause unwanted side effects, so the specialist must take into account the patient's condition, his chronic pathologies, the severity of the disease, and possible reactions of the body.

The main side effects of Indapamide:

allergic skin rashes;
dry cough;
dizziness;
confusion;
feeling of fear;
arrhythmia at rest;
dryness in the mouth;
loss of appetite;
dyspnea;
bed-wetting;
changes in the data of the clinical picture of blood.

If you feel worse, you should stop taking Indapamide, consult a doctor. Taking the medication in a therapeutic dosage prescribed by specialists is well tolerated, does not cause negative changes in the state of health.

Application of Indapamide

How to take the drug Indapamide, the attending physician will indicate. The standard regimen that is usually prescribed is a single dose of Indapamide per day. The tablet is swallowed whole, without chewing, washed down with the required volume of liquid. It is better to take Indapamide not on an empty stomach, so as not to provoke irritation of the mucous membrane with chemicals.

If a month after taking the medication there is no positive result, then another drug is prescribed that reduces blood pressure, but not a diuretic.

Contraindications to prescribing the drug

Indapamide has contraindications, therefore, before its use, tests are often taken to monitor the patient's condition. Patients with chronic heart failure, liver cirrhosis, ischemia require special attention. When Indapamide is prescribed to patients with such diagnoses, the likelihood of metabolic alkalosis and hepatic encephalopathy increases.

Contraindications to the appointment are:

violation of the formation of urine;
anuria;
circulatory disorders in the brain structures;
low potassium;
allergy to the components of the drug;
gout;
children's age up to 18 years;
kidney failure.

Indapamide is not prescribed to women during pregnancy, as there are no laboratory studies in this group of patients. There is no data on the effect of active substances on fetal development. When breastfeeding, the drug Indapamide is also not prescribed. If it is necessary to treat a nursing woman with this particular drug, breastfeeding is stopped.

Possibility of overdose

Taking Indapamide in a dosage higher than prescribed by doctors can lead to undesirable consequences. An overdose is dangerous for humans, so the dosage prescribed by specialists should be strictly observed. Increased intake of Indapamide provokes apathy and severe dizziness, blood pressure is greatly reduced, possibly respiratory depression. Against the background of a violation of the water-salt balance, an accelerated excretion of potassium and sodium will occur. With an increase in the dose of Indapamide, which is prescribed by doctors, a malfunction in the digestive system will begin.

To treat the above symptoms, gastric lavage is usually prescribed. There is no antidote for Indapamide. Washing is prescribed until clear water appears instead of vomit. You can give the affected person an enterosorbent, for example, activated charcoal at the rate of 1 tablet per kilogram of weight. Polysorb, Enterosgel are also suitable (use according to the instructions). If the condition worsens, seek medical attention.

Special instructions for the use of Indapamide

Indapamide has a cumulative effect. But if during the month of admission there is no positive result in the treatment, the dosage cannot be exceeded, this will lead to complications. It is necessary to consult with the attending physician, in such cases, a new regimen for taking Indapamide is prescribed.

The best time to take Indapamide is in the morning. At the beginning of taking Indapamide, it is prescribed to drink more water so that there is no disturbance in the balance of electrolytes in the blood. Often in the first days of taking the drug, dizziness, weakness, lethargy are observed. At this time, it is better to refrain from driving vehicles, working at heights that require good attention and reaction.

When Indapamide is prescribed for high blood pressure, patients with diabetes need to adjust the daily dosage of hypoglycemic agents. Patients who take cardiac glycosides are prescribed to regularly monitor blood potassium levels and creatinine.

Similar drugs

Instead of Indapamide, other medicines from the group of drugs are sometimes prescribed, which have a similar composition and mechanism of action. Analogues are prescribed by specialists, taking into account possible consequences, providing for the reaction of the body.

Similar drugs for Indapamide will be:

Arifon Retard. The active ingredient is indapamide. Assign to elderly patients over 80 years of age, patients with diabetes mellitus. Easy to use, well tolerated, has few side effects. It is not recommended for athletes, as it gives a positive reaction to doping tests. Do not prescribe for co-administration with antidepressants, as it can cause a sharp decrease in blood pressure.

Enziks. The active substance is indapamide. The medication is available in the form of a set of tablets of different sizes. Each contains a certain amount of active substance. The drug is prescribed for a prolonged increase in blood pressure. A large tablet from the set reduces pressure, a small one is a diuretic. If a positive effect does not appear after a month of taking the drug, then a larger dosage is prescribed. The doctor himself decides whether or not to enhance the diuretic effect of the drug. During pregnancy and lactation, the drug is not prescribed.

Ionic. The drug is prescribed for high blood pressure, chronic heart failure. Also in the complex treatment of diabetes and obesity, which are accompanied by high blood pressure. The active substance is indapamide. Do not prescribe the drug to pregnant, lactating women, since a decrease in potassium increases the risk of developing pathologies in the fetus, and a decrease in blood pressure can cause hypoxia.

Indapen. The main active ingredient is indapamide. With prolonged use of the drug, it is prescribed to regularly take tests for the content of calcium and sodium levels. Simultaneous reception with antidepressants contributes to a sharp decrease in blood pressure. For athletes, there is a risk of false positive doping tests during treatment. In the first days of therapy, dizziness and weakness are observed, you need to be careful when driving.

Indopress. The main active substance is indapamide. Has a cumulative effect. A positive result is achieved with regular use. If it is not possible to achieve a therapeutic effect, an increase in dosage is prescribed. Produced in Ukraine. By lowering blood pressure, dizziness is possible, so driving is not recommended during the entire time of treatment with this medication. Do not prescribe to pregnant and lactating women, children under 18 years of age. Patients over 65 years of age require dose adjustment, monitoring of blood counts.

Synonyms of Indapamide are Indapsan, Indap, Lorvas, Pamid, Indapamide retard. That is, under such names, the same drug can be sold in pharmacies. What can replace the original drug prescribed by doctors. But it is better to buy a real medicine than a similar one.

Indapamide is a diuretic that helps to bring blood pressure back to normal. The drug, along with urine, sodium is excreted, accelerates the work of calcium channels, helps to ensure that the arterial walls become more elastic. It belongs to thiazide diuretics. It is used to treat hypertension and as a remedy for edema caused by heart failure.

Pharmacological action and pharmacokinetics

Diuretic agent with active ingredient - indapamide.

The latter resembles a thiazide diuretic in its structure. Indapamide is a sulfonylurea derivative.

Due to the peculiarities of the mechanism of action, the drug does not significantly affect the amount of urination.

So all the same, what is the medicine indapamide for? The action of the active substance reduces the load on the heart, dilates the arterioles, and reduces blood pressure. And at the same time, it does not affect carbohydrate and lipid metabolism, even in patients with diabetes.

Another of its abilities is to reduce peripheral vascular resistance. Able to reduce the volume and mass of the left ventricle. The hypotensive effect is felt even by patients requiring chronic hemodialysis.

Pharmacokinetics

The bioavailability of the drug is 93%. In the blood for 1-2 hours, the period of maximum concentration of the substance begins. Indapamide is well distributed in the body. Able to pass through the placental barrier and stand out in breast milk.

The drug is 71-79% bound to blood proteins - a high rate. The metabolic process takes place in the liver with the formation of inactive metabolites. The active substance is excreted from the body with urine - 70%, the remaining 30% - with feces.

The half-life of indapamide is 14-18 hours. It is not known whether this time varies with renal and hepatic insufficiency.

Indapamide belongs to the pharmacological groups:

Thiazide-like and thiazide diuretics; Drugs that affect the renin-angiotensin system.

Mechanism of action of indapamide

Increased synthesis of prostacyclin and prostaglandin; Relaxes vascular smooth muscle cells - the result of a change in the transmembrane current of calcium and other ions.

Indapamide: indications for use

Essential arterial hypertension

Application

Drink no more than one capsule a day, take it orally: you need to swallow whole, do not chew. Drink a small amount of liquid.

It is possible to increase the dosage only after consulting a doctor. You need to be prepared for a greater diuretic effect, but at the same time, there is no increase in the hypotensive effect.

Side effects of indapamide

Using the drug in recommended therapeutic doses, there are rare cases of side effects. In long-term clinical studies, side effects were recorded in only 2.5% of patients. Among them, electrolyte disturbances are common. Other side effects include:

Skin and allergic reactions: Lyell's syndrome, Stevens-Johnson syndrome, anaphylactic shock, urticaria, photodermatosis, skin rashes, purpura, Quincke's edema. Influence on the nervous system: dizziness, paresthesia, nervousness, body aches, vertigo, headache, weakness may occur. The effect on the digestive system is manifested by nausea, vomiting, dry mouth, impaired liver function, pancreatitis, constipation. From the side of the heart and blood vessels are possible: arrhythmia, prolongation of the QT interval on the electrocardiogram, orthostatic arterial hypotension. Influence on laboratory tests: rare cases of thrombocytopenia, anemia, leukopenia, agranulocytosis, hypercalcemia, hyponatremia, hypokalemia, hyperglycemia, increased levels of urea and creatinine in the blood. Respiratory effects: cough, rare cases of pharyngitis, sinusitis.

Indapamide pressure pills: contraindications

Violations in the liver. Anuria. Allergy to the active substance. Gout. Children under 18 - no experience in this age group. Pregnancy, lactation period. During the bearing of a child, the use of the drug is unjustified. Indapamide can lead to fetal hypotrophy. If during breastfeeding the use is extremely necessary, then it is worth weaning the baby from mother's milk. The medicine will pass through it to the baby. Circulatory disorders in the brain (recent or acute). Hypokalemia. Use with drugs that increase the Q-T interval.

Before prescribing the drug, the patient often takes all kinds of tests. Especially if there is a suspicion that the medicine can provoke water-salt changes. If the drug is nevertheless prescribed, then it is worth periodically taking tests for the content in the blood plasma devoid of fibrinogen, sodium, potassium and magnesium.

It also requires constant monitoring of the level of residual nitrogen, glucose, uric acid, pH. The doctor is obliged to take under his supervision patients with cardiovascular insufficiency (chronic form), coronary heart disease, cirrhosis of the liver. These patients are more likely than all others to develop metabolic alkalosis and hepatic encephalopathy.

Indapamide + other drugs

The hypotensive effect of the drug is impaired under the influence of salicylates in high dosages and systemic non-steroidal anti-inflammatory drugs. If the patient is dehydrated, the use of indapamide will lead to renal failure. The solution is fluid replenishment in the body. The combination with drugs that contain lithium salts increases the amount of lithium in the blood due to reduced excretion of the element. If such a connection is unavoidable, the patient needs to monitor the level of lithium in the blood. Glucocorticosteroids and tetracosactides neutralize the hypotensive effect of the drug. The reason is that water and sodium ions are retained in the body. Laxatives based on intestinal peristalsis are provocateurs of hypokalemia. If such drugs are used in parallel, it is necessary to monitor potassium in the blood serum in order to diagnose hypokalemia in a timely manner. Hyperkalemia is caused by a combination of the described diuretic with diuretics, which provide potassium conservation. The risk of developing acute renal failure and arterial hypotension increases with the use of ACE inhibitors. Cyclosporine with indapamide lead to an increase in plasma creatinine. The radiopaque substance causes kidney failure. Estrogen-containing drugs neutralize the hypotensive effect. The reason is that water is retained in the body. Hypercalcemia is possible due to the intake of calcium salts. Tricyclic antidepressants lead to a severalfold increase in hypotensive action.

If there is no result within a month, in no case increase the dosage of indapamide - it will lead to side effects. Instead, it is worth reviewing the treatment regimen. This drug is often prescribed as part of a complex treatment. Indapamide is a drug for long-term use. A stable effect is noticeable after two weeks. The maximum effect is after 12 weeks. The action from a single application occurs in one to two hours. The best time to take the drug is in the morning on an empty stomach.

With the manifestation of side effects, doctors talk about two possible options for action. The first is to stop using the drug. The second is to reduce the dose. The second option is rarely considered, since the side effects of the drug are dangerous. Indapamide will lead to impaired liver function, changes in the chemical composition of the blood, anorexia.

What to replace?

If the pharmacy does not have the described drug, then it can be replaced with another one with a similar effect. In this case, they can have a different form: dragees, tablets, capsules. But this does not affect the pharmacological properties.

Indapamide analogues - identical action in drugs with another active substance:

Ionic; Indopres; Enziks; Arifon retard; Indapen; Indapamide perindopril.

Synonyms of the drug indapamide - drugs with an identical active substance (INN):

Indapamide retard; Indap; Indapsan; Lorvas; Pamid; Lescopride; Frantel.

Without consulting a doctor, but with the help of a pharmacist, you can independently replace indapamide with another synonymous drug. But analogues should be bought only after the doctor's recommendation!

Overdose

A dosage of 40 mg is toxic - it exceeds the permissible single dose by almost 30 times. Overdose symptoms are: oliguria / polyuria, constant desire to sleep, hypotension, nausea / vomiting, dizziness. A toxic dose upsets the balance of salt and water in the body.

You can remove the drug from the body by washing the stomach and drinking enterosorbents (activated charcoal). Further actions are symptomatic treatment, which is carried out exclusively at the hospital.

Note to athletes

Although indapamide tablets are not directly drugs that can be used as doping to improve athletic performance. But at the same time, the World Anti-Doping Agency banned the use of any diuretics by athletes. The reason is that they help to hide the fact of doping. And the detection of indapamide in the body of an athlete during the competition can cause him to be disqualified.

Influence on reaction

You need to be careful when taking the medicine if you are a driver of a vehicle or are engaged in one of the potentially dangerous activities. It is forbidden to prescribe the medicine to those who work in constant tension, in a state of increased concentration of attention, for whom the speed of reaction is important.

Reviews about indapamide

Advantages of this drug: a mild diuretic that normalizes blood pressure.

Disadvantages: side effects are possible (but this is more of a norm than a negative).

Dmitry, 52 years old. This drug was prescribed to me by a neurologist. I take it in combination with Losartan, because I constantly have high blood pressure. Indapamide has a cumulative effect. You can wake up in the morning, measure the pressure, but it is normal, but you still need to drink the medicine, otherwise the effect of the drug will worsen.

I do not suffer from constant high blood pressure, sometimes there are jumps. Therefore, I do not take indapamide pressure tablets daily, but only when necessary. I notice its effect for several hours. After the jumps, I drink for 10 days in a row for better and stable normalization of blood pressure. This course is enough for me. Conveniently, you need to drink it once a day, and it does not noticeably increase the number of trips to the toilet.

The drug frightened me with the number of side effects, I read a lot on the Internet and already thought that I would not buy it. But the doctor prescribed, and I obediently began to drink. I made several conclusions for myself:

You need to drink the entire course, even if it seems that the pressure is already normal; The drug acts quickly; There were no side effects.

The drug "Indapamide" acts on the vascular walls, relaxing them and normalizing the elasticity of the muscles. Thanks to this drug, arterioles increase, which leads to the unhindered movement of blood in the body. Tablets "Indapamide" - a medicine for pressure. It is a vasodilator, pharmacodynamically similar to a thiazide diuretic. During the day, the amount of urine produced increases slightly. Together with it, the predominant ions of sodium, chlorine, and potassium are removed from the body. While taking the drug, carbohydrate and fat metabolism remain normal, which makes it possible for patients suffering from obesity or diabetes to take the drug. With a pronounced increase in the left ventricle of the heart, the drug "Indapamide" significantly reduces the level of hypertrophy. With regular use of the drug, the effect is achieved after 2 weeks, and after 10 weeks, the maximum beneficial effect is noted. A single dose of the drug "Indapamide" retains its therapeutic properties for up to 24 hours.

Pharmacokinetics

The pressure drug "Indapamide" is rapidly absorbed in the gastrointestinal tract and excreted from the body mainly with urine. The content of inactive metabolites in feces is about 20%. The diuretic interacts with plasma and red blood cells, penetrates into breast milk. With regular use of the drug, cumulation was not observed. Patients with hepatic insufficiency should use this medicine with caution in order to avoid the formation of hepatic encephalopathy.

Indications for use

What does the medicine "Indapamide" help from? Indications for its use are:

Arterial hypertension. Chronic heart failure (sodium and water retention in the body).

Contraindications

The drug is limited to the following diseases:

Violation of liver function. Violation of kidney function. Intolerance to the components of the drug.

In what cases can there be complications when using the drug "Indapamide"

Lactose intolerance. Pregnancy and lactation. Age up to 18 years. Unstable water and electrolyte balance.

Method of application, dosage

The drug is taken orally 1 time per day, 2.5 mg. Morning intake is more effective, since a large amount of food slows down the absorption of the drug. Tablets should be swallowed without chewing, drinking plenty of water. An increase in the dose of the drug "Indapamide" does not lead to an acceleration of the therapeutic effect, but causes a number of side effects. Patients suffering from heart failure, in the absence of improvement, are prescribed a dose of 5 mg per day.

Adverse reactions

When taking the drug "Indapamide" (from which it is prescribed, we already know) a side effect may occur. First of all, this happens when using an increased dose of the drug, intolerance of the substance by the body, the impact of individual components on a specific organ system. Side effects can manifest themselves in different ways.

Central nervous system: headache, drowsiness, asthenia, insomnia, irritability. Respiratory system: pharyngitis, acute cough. Digestive system: nausea, vomiting, diarrhea. Urinary system: nocturia, infectious inflammation. Cardiovascular system: arrhythmia, palpitations, hypokalemia. Skin diseases: itching, urticaria, rash.

Price

The average price of the drug "Indapamide" in Russia is 12 rubles. The package contains 30 tablets of 2.5 mg.

Interaction with other drugs

Anti-inflammatory drugs reduce the effect of the drug "Indapamide", quickly consume fluid in the body, which is why it has to be constantly replenished. When taking Indapamide tablets, what determines the compatibility with other drugs? The composition of the diuretic is quite complex, so complex treatment is selected by a specialist strictly individually, based on the prescribed drugs.

Preparations containing lithium are rapidly excreted in the urine, so it is necessary to control the level of the substance in the blood serum. GCS, on the contrary, retain water in the body, reducing the antihypotensive effect. Cardiac glycosides reduce the amount of potassium in the body, which can lead to hypokalemia. Calcium: an increase in salt content in the body. X-ray contrast preparations containing a significant amount of iodine can lead to the development of renal failure. Tricyclic antidepressants cause the risk of orthostatic hypotension.

special instructions

Which patients need careful monitoring of their condition while taking the drug "Indapamide"? What do they need to watch out for? Patients with cirrhosis of the liver, heart, kidney, liver failure are required to undergo treatment with the drug "Indapamide" strictly under the supervision of doctors. The possible occurrence of dehydration in the body leads to an exacerbation of organ dysfunction. It is important to control the fluid content in the body and compensate for it in time.

Many of us, having crossed the forty-year milestone, and some of us before reaching it, will learn what high blood pressure is from our own experience. The modern pharmacological industry is replete with all kinds of drugs that help fight this disease. Nobody disputes this fact. It is much more important to find out the cause that led to arterial hypertension and, if possible, eliminate it, but this cannot always be done quickly. In such a situation, the doctor selects an individually antihypertensive drug. One of the drugs that successfully helps to cope with high blood pressure is Indapamide (INDAP).

Let's take a closer look at the drug Indapamide - description, instructions, price, contraindications of the drug.

Indapamide - instructions for use

Indapamide is a drug that is used to treat hypertension due to its diuretic action. This effect is achieved due to its wagging on the kidneys and vascular tone.

"Indapamide" changes the permeability of cell membranes for calcium and reduces the contractility of the walls of blood vessels. As a result, small arteries dilate, precardiac workload decreases, and blood pressure decreases.

At the level of the kidneys, Indapamide prevents the reabsorption of sodium into the body and does not greatly affect the excretion of potassium, magnesium, and chlorine in the urine. When taking therapeutic doses of the drug, a hypotensive effect is noted without a significant increase in the amount of urine excreted per day.

Description of the drug Indapamide says that it does not change the metabolism of lipids, carbohydrates, including in patients with diabetes. Long-term use of the drug reduces left ventricular hypertrophy. Indapamide can be used even by patients on chronic hemodialysis.

After indapamide is taken orally, it is rapidly absorbed from the gastrointestinal tract. If you drink the drug with food, then the rate of absorption decreases, but does not affect the amount of the drug that has entered the body. A dosage form of Indapamide with prolonged action has been created, which allows the substance to be released evenly over 24 hours. This made it possible to prescribe the drug once a day - in the morning. The maximum concentration of Indapamide in the blood is observed 12 hours after its administration.

Indications for use and doses

The instructions say that the drug is prescribed for the treatment of arterial hypertension. It is taken orally in the morning before meals, one tablet or capsule (1.25 and 2.5 mg) without chewing, with a small amount of water. Indapamide can be prescribed alone or in combination with other antihypertensive drugs. It is not recommended to increase the dose of the drug, its ability to lower blood pressure does not increase from this, and the diuretic effect increases. Has Indapamide contraindications.

Contraindications

Severe renal dysfunction: renal insufficiency, not corrected by hemodialysis, lack of urine (anuria);
abnormal liver function, including with brain damage (hepatic encephalopathy);
allergy to Indapamide and its components;
children under 18;
pregnancy and breastfeeding;
not long ago acute cerebrovascular accident;
in combination with drugs that increase the Q-T interval on the ECG (cisapride);
low levels of potassium in the blood;

Side effects

They rarely occur, but they are listed in the instructions:

Nervous system: fatigue, headaches, vertigo (feeling that any objects or the patient himself are in constant motion), muscle pain, weakness;
heart and blood vessels: lowering blood pressure, cardiac arrhythmias;
blood: anemia, decreased platelet count;
a decrease in the blood of microelements below the norm and entailing pathological conditions: potassium, sodium, calcium, chlorine;
an increase in the content of uric acid in the body;
digestive system: nausea, dry mouth, constipation, impaired liver function;
allergic reactions: allergic rash, urticaria;
exacerbation of systemic lupus erythematosus;
respiratory system: cough, pharyngitis, sinusitis, frontal sinusitis;

Interaction of Indapamide with other drugs

The drug Indapamide and lithium preparations are not recommended to be used together, it is possible to increase the toxic effect of lithium on the body.
The hypotensive effect of Indapamide can be reduced by its combined use with the following drugs: adrenostimulants, glucocorticoids (prednisolone) and non-steroidal anti-inflammatory drugs.
Taking certain drugs together with Indapamide can reduce the effectiveness of the latter, as well as cause arrhythmia. These are erthromycin, pentamidine, vincamine, sultopyrpd, tarfedin, astemizole, antiarrhythmic drugs (quinidine, disopyramide, amidoran, sotalol, bretilium).
The risk of a decrease in potassium in the blood increases if Indapamide is combined with diuretics, cardiac glycosides, laxatives, glucocorticoids, amphotericin B.
Antidepressants enhance the ability of Indapamide to lower blood pressure.

The price of Indapamide depends on the manufacturer and weight of the tablet and ranges from 13 to 90 rubles for 20 tablets from 1.5 to 2.5 mg.

Attention!

This instruction in the article is given in free form, before using Indapamide, be sure to consult with your doctor.

There are many drugs available for the treatment of hypertension. But which one is really effective? If you bought "Indapamide", the instructions for use must be strictly followed. At what pressure is the drug recommended? At elevated. The drug has a mild effect and is available in tablet form. The main active ingredient indapamide is contained in the preparation in two dosages: 1.5 and 2.5 mg.

Operating principle

The drug belongs to the group of thiazide diuretics. It lowers blood pressure (BP), eliminates swelling. The therapeutic effect is based on the ability to excrete chloride ions, excess sodium, magnesium and potassium from the body through the urinary system. Calcium channels begin to function better, the elasticity of arterial and venous walls increases, they resist pressure less.

"Indapamide": pills for pressure

After taking the pill, the maximum therapeutic effect occurs in a day. A stable improvement in pressure indicators is observed after 14 days of regular intake. Absorption of active components occurs almost immediately after entering the gastrointestinal tract, then they spread with the bloodstream. How quickly the drug is absorbed depends to a small extent on food intake. Excreted by the kidneys with urine.

"Indapamide": from what pressure?

The drug is indicated for arterial hypertension along with other medicines or as the main element of monotherapy.

Tablets "Indapamide" belong to the group of diuretics and drugs for hypertension

"Indapamide" from pressure: how to take?

It is advisable to take the medicine before meals without chewing, drinking plenty of fluids. Best taken in the morning. Usually prescribed 2.5 mg of the active ingredient per day. If a positive therapeutic effect is not observed within 1–2 months, antihypertensive drugs with other pharmacological effects are included in the treatment regimen.

An increase in the dosage of the drug does not affect the effectiveness of pressure reduction, but only enhances the diuretic effect. It is better to check with the doctor in more detail how to take "Indapamide" at high pressure. To achieve a stable therapeutic effect, the medicine must be taken daily at the same time.

special instructions

To achieve a therapeutic result without negative consequences, you must adhere to the recommendations:

For elderly patients, the medicine is prescribed provided that there is no pathological condition of the kidneys of a chronic nature. During the entire course of therapy, the level of creatine and potassium ions in the blood should be monitored.

The diuretic drug "Indapamide" is able to effectively reduce blood pressure

In the 1st trimester of pregnancy, the drug is not prescribed because of the threat to the development of the fetus. In the 2nd and 3rd trimesters, the drug is prescribed if the benefit to the mother outweighs the possible risk to the fetus.
The active ingredients pass into the mother's breast milk, so the drug is contraindicated in lactation.
Clinical studies on patients under 18 years of age have not been conducted, so the drug is not prescribed for this category of patients.
At the beginning of treatment, dizziness may occur. During this period, it is undesirable to drive a vehicle or perform work that requires increased concentration.
The drug is incompatible with alcohol due to the high likelihood of developing negative consequences - a stroke, an acute form of heart failure.

The drug effectively lowers blood pressure

Side effects

The drug has a diuretic effect, so it can provoke a number of negative consequences:

hives;
angioedema;
dizziness;
feeling of weakness;
headache;
excessive nervousness;
nausea;
constipation;
violation of the functioning of the liver;
cardiopalmus;
dry cough;
anemia;
hypokalemia.

Contraindications

"Indapamide" under pressure is contraindicated in:

Anuria.
chronic arrhythmias.
Component intolerance.
Pregnancy.
Kidney dysfunction.
lactation.
diabetes mellitus.

A more detailed list of contraindications is contained in the instructions. "Indapamide" at low pressure is not prescribed.

Overdose

If the treatment regimen is not followed, overdose symptoms appear:

dry mouth;
thirst;
nausea;
weakness;
vomit.

An overdose of the drug can cause weakness in the body, drowsiness and disturbances in the digestive tract.

Drink plenty of water immediately to flush out the stomach and induce vomiting.

Combined use with other medicines

"Indapamide" - tablets for high blood pressure - can not be combined with all drugs:

NPS and salicylates. Reduce the hypotensive effect.
Medicines based on lithium salts. Increase the concentration of lithium in the blood.
Glucocorticosteroids. Reduce the hypotensive effect.
Medications with a diuretic effect. Provoke acute hyperkalemia.
ACE inhibitors. Provoke acute renal failure and chronic hypotension.
Cyclosparin. Increases the content of creatinine in the blood.
Salts of calcium. Cause acute hypercalcemia.
Tricyclic antidepressants. Strongly increase the severity of the hypotensive effect.

Analogues

With the development of side effects, the doctor may decide on the advisability of replacing Indapamide with analogues. They have the same properties and therapeutic effect, but they contain a different active substance.

The most common analogues:

"Indapen".
"Indopress".
"Ionic".
"Arifon retard".

Medications based on indapamide:

"Lorvas".
"Indap".
"Frantel".
Pamid.

Analogues differ in manufacturer and form of release.

"Indapamide" from pressure: reviews

Konstantin, 55 years old: “I have been taking the drug for a year. I used to constantly suffer from high blood pressure, but now my condition has improved. And all thanks to Indapamide. You have to take pills every day, but the result is worth it.

Olga, 44 years old: “Sudden jumps in blood pressure are often disturbing. The doctor prescribed this drug. Relief comes in the first hours. For prevention, I take 1 tablet every morning.

Maxim, 48 years old:

“Hypertension manifests itself several times a year. Tablets help me a lot. But to achieve the result, you have to take the medication every day. ”